C9ORF50

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein targeting to Golgi (GO:0000042)8.50006555
2establishment of protein localization to Golgi (GO:0072600)8.13134059
3fusion of sperm to egg plasma membrane (GO:0007342)7.99710681
4retrograde transport, vesicle recycling within Golgi (GO:0000301)7.93144212
5protein polyglutamylation (GO:0018095)7.49493036
6acrosome reaction (GO:0007340)7.25109803
7seminiferous tubule development (GO:0072520)7.02779140
8DNA packaging (GO:0006323)6.92611225
9chromosome condensation (GO:0030261)6.86568119
10centriole replication (GO:0007099)6.78013641
11rRNA methylation (GO:0031167)6.74465958
12microtubule depolymerization (GO:0007019)6.58662538
13sperm capacitation (GO:0048240)6.48026290
14microtubule polymerization or depolymerization (GO:0031109)6.45527227
15protein localization to Golgi apparatus (GO:0034067)6.34992610
16spermatid development (GO:0007286)6.15255490
17centriole assembly (GO:0098534)6.06711647
18plasma membrane fusion (GO:0045026)5.93643584
19axonemal dynein complex assembly (GO:0070286)5.91830024
20spermatogenesis (GO:0007283)5.90764658
21male gamete generation (GO:0048232)5.88757616
22regulation of centriole replication (GO:0046599)5.84674594
23synaptonemal complex assembly (GO:0007130)5.75953557
24male meiosis I (GO:0007141)5.64027615
25cilium or flagellum-dependent cell motility (GO:0001539)5.63690823
26synapsis (GO:0007129)5.62521103
27rRNA modification (GO:0000154)5.59058985
28chromosome organization involved in meiosis (GO:0070192)5.55786746
29gamete generation (GO:0007276)5.50299137
30sperm-egg recognition (GO:0035036)5.41506084
31glomerular visceral epithelial cell development (GO:0072015)5.36176843
32piRNA metabolic process (GO:0034587)5.31309790
33microtubule severing (GO:0051013)5.29600919
34multicellular organism reproduction (GO:0032504)5.19296959
35phosphatidylethanolamine biosynthetic process (GO:0006646)5.15478342
36synaptonemal complex organization (GO:0070193)5.10782927
37glomerular epithelial cell development (GO:0072310)4.95929271
38phosphatidylethanolamine metabolic process (GO:0046337)4.83888032
39negative regulation of inclusion body assembly (GO:0090084)4.81342152
40epithelial cilium movement (GO:0003351)4.81277671
41regulation of cilium movement (GO:0003352)4.77819638
42fertilization (GO:0009566)4.75768452
43spermatid nucleus differentiation (GO:0007289)4.68921041
44microtubule nucleation (GO:0007020)4.62446327
45multicellular organismal movement (GO:0050879)4.58553047
46musculoskeletal movement (GO:0050881)4.58553047
47binding of sperm to zona pellucida (GO:0007339)4.56223386
48reproduction (GO:0000003)4.55475161
49single strand break repair (GO:0000012)4.51512980
50meiosis I (GO:0007127)4.46987198
51calcium ion-dependent exocytosis (GO:0017156)4.46299228
52cilium movement (GO:0003341)4.41648831
53RNA destabilization (GO:0050779)4.37838072
54cell-cell recognition (GO:0009988)4.37663939
55motile cilium assembly (GO:0044458)4.37525052
56cell wall macromolecule catabolic process (GO:0016998)4.36882846
57multicellular organismal reproductive process (GO:0048609)4.35004230
58male meiosis (GO:0007140)4.33754019
59single fertilization (GO:0007338)4.31846389
60DNA methylation involved in gamete generation (GO:0043046)4.11973347
61cell wall macromolecule metabolic process (GO:0044036)4.07143759
62meiotic cell cycle process (GO:1903046)3.98172948
63regulation of meiosis I (GO:0060631)3.91999031
64positive regulation of Rab GTPase activity (GO:0032851)3.90379966
65regulation of Rab GTPase activity (GO:0032313)3.90379966
66germ cell development (GO:0007281)3.81771235
67cellular process involved in reproduction in multicellular organism (GO:0022412)3.73458732
68meiotic nuclear division (GO:0007126)3.66918386
69intra-Golgi vesicle-mediated transport (GO:0006891)3.60605702
70resolution of meiotic recombination intermediates (GO:0000712)3.54699587
71sexual reproduction (GO:0019953)3.52831490
72ventricular system development (GO:0021591)3.49560860
73axoneme assembly (GO:0035082)3.45854010
74acrosome assembly (GO:0001675)3.44397121
75regulation of inclusion body assembly (GO:0090083)3.43103822
76regulation of microtubule-based movement (GO:0060632)3.42830735
77nuclear pore complex assembly (GO:0051292)3.41686649
78peptidyl-glutamic acid modification (GO:0018200)3.22713492
79DNA synthesis involved in DNA repair (GO:0000731)3.17798044
80membrane protein intracellular domain proteolysis (GO:0031293)3.13679865
81cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.12432617
82nucleus organization (GO:0006997)3.07913221
83Golgi to endosome transport (GO:0006895)3.06540585
84regulation of centrosome duplication (GO:0010824)3.04706902
85epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.97722563
86tRNA methylation (GO:0030488)2.92754539
87histone H3-K9 demethylation (GO:0033169)2.92095032
88centrosome duplication (GO:0051298)2.91722825
89protein K48-linked deubiquitination (GO:0071108)2.89576054
90response to pheromone (GO:0019236)2.85518904
91regulation of transcription involved in cell fate commitment (GO:0060850)2.80403663
92cellular response to pH (GO:0071467)2.71566269
93pore complex assembly (GO:0046931)2.71029576
94RNA localization (GO:0006403)2.67236972
95multicellular organismal development (GO:0007275)2.64375673
96RNA methylation (GO:0001510)2.63359046
97cilium organization (GO:0044782)2.62448175
98organic cation transport (GO:0015695)2.61616555
99negative regulation of Rho protein signal transduction (GO:0035024)2.59221636
100sperm motility (GO:0030317)10.0310767

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.64965639
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.24013050
3EZH2_22144423_ChIP-Seq_EOC_Human3.43316899
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.96084864
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23230398
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13034781
7FUS_26573619_Chip-Seq_HEK293_Human2.07895044
8DROSHA_22980978_ChIP-Seq_HELA_Human2.05848323
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01426938
10CBP_20019798_ChIP-Seq_JUKART_Human2.01191273
11IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.01191273
12TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92340423
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.92340423
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.88415808
15ERA_21632823_ChIP-Seq_H3396_Human1.79079410
16SMC4_20622854_ChIP-Seq_HELA_Human1.72715814
17RAC3_21632823_ChIP-Seq_H3396_Human1.71306755
18ER_23166858_ChIP-Seq_MCF-7_Human1.70959272
19MYC_19829295_ChIP-Seq_ESCs_Human1.62174829
20AR_21572438_ChIP-Seq_LNCaP_Human1.61302105
21WDR5_24793694_ChIP-Seq_LNCAP_Human1.57201608
22ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.56346692
23* P68_20966046_ChIP-Seq_HELA_Human1.54435511
24EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.51614952
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49824987
26ELF1_20517297_ChIP-Seq_JURKAT_Human1.48871320
27CTCF_27219007_Chip-Seq_Bcells_Human1.47214559
28ARNT_22903824_ChIP-Seq_MCF-7_Human1.46346715
29TP53_18474530_ChIP-ChIP_U2OS_Human1.45186154
30CTCF_20526341_ChIP-Seq_ESCs_Human1.43906603
31TAF2_19829295_ChIP-Seq_ESCs_Human1.43564927
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41747050
33VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.40927465
34YY1_22570637_ChIP-Seq_MALME-3M_Human1.40761126
35SMAD4_21741376_ChIP-Seq_EPCs_Human1.39968482
36BCL6_27268052_Chip-Seq_Bcells_Human1.39576450
37EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.38657913
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37887666
39RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.35950674
40TP63_22573176_ChIP-Seq_HFKS_Human1.33723267
41OCT4_20526341_ChIP-Seq_ESCs_Human1.32675645
42PHF8_20622854_ChIP-Seq_HELA_Human1.31486363
43E2F1_20622854_ChIP-Seq_HELA_Human1.29830771
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.29635934
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29387729
46RUNX1_26923725_Chip-Seq_HPCs_Mouse1.29237745
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29161341
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26154320
49AUTS2_25519132_ChIP-Seq_293T-REX_Human1.25363364
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.23714148
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.22982392
52AR_25329375_ChIP-Seq_VCAP_Human1.21489583
53* STAT3_23295773_ChIP-Seq_U87_Human1.21035828
54GBX2_23144817_ChIP-Seq_PC3_Human1.20156197
55KLF4_19829295_ChIP-Seq_ESCs_Human1.19778386
56TBL1_22424771_ChIP-Seq_293T_Human1.18174555
57CBX2_22325352_ChIP-Seq_293T-Rex_Human1.17878104
58BCOR_27268052_Chip-Seq_Bcells_Human1.17559276
59JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17464801
60PKCTHETA_26484144_Chip-Seq_BREAST_Human1.17227548
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.17133481
62ZNF274_21170338_ChIP-Seq_K562_Hela1.16719183
63ERG_20517297_ChIP-Seq_VCAP_Human1.15642809
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15046046
65CJUN_26792858_Chip-Seq_BT549_Human1.14229479
66HNFA_21074721_ChIP-Seq_CACO-2_Human1.13692771
67SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13218637
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12818381
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12722748
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11223999
71NANOG_20526341_ChIP-Seq_ESCs_Human1.10826465
72CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.10277667
73RBPJ_21746931_ChIP-Seq_IB4_Human1.09517242
74PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08699026
75NFYB_21822215_ChIP-Seq_K562_Human1.08030832
76* SMAD3_21741376_ChIP-Seq_ESCs_Human1.07597211
77P300_19829295_ChIP-Seq_ESCs_Human1.07377995
78ETV1_20927104_ChIP-Seq_GIST48_Human1.07276301
79P53_21459846_ChIP-Seq_SAOS-2_Human1.06891058
80E2F1_17053090_ChIP-ChIP_MCF-7_Human1.06299532
81PHF8_20622853_ChIP-Seq_HELA_Human1.05002839
82CEBPB_22108803_ChIP-Seq_LS180_Human1.04782628
83TDRD3_21172665_ChIP-Seq_MCF-7_Human1.04566236
84AHR_22903824_ChIP-Seq_MCF-7_Human1.04555420
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04532755
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04353491
87CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04346715
88* KLF5_25053715_ChIP-Seq_YYC3_Human1.02182567
89SOX2_22085726_ChIP-Seq_NPCs_Mouse1.02114820
90SMAD4_21799915_ChIP-Seq_A2780_Human1.01463708
91JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99271747
92P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.98627956
93* LXR_22292898_ChIP-Seq_THP-1_Human0.98345985
94KDM2B_26808549_Chip-Seq_REH_Human0.97491742
95RUNX2_22187159_ChIP-Seq_PCA_Human0.96305778
96JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96144974
97RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96056382
98FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95653399
99TET1_21490601_ChIP-Seq_MESCs_Mouse0.94779206
100EZH2_27294783_Chip-Seq_ESCs_Mouse0.94021423

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.56225470
2MP0003878_abnormal_ear_physiology5.15306126
3MP0005377_hearing/vestibular/ear_phenot5.15306126
4MP0003698_abnormal_male_reproductive3.80422714
5MP0001929_abnormal_gametogenesis3.64439632
6MP0005670_abnormal_white_adipose3.33019438
7MP0005423_abnormal_somatic_nervous2.82750132
8MP0003646_muscle_fatigue2.79076148
9MP0001485_abnormal_pinna_reflex2.48938265
10MP0001348_abnormal_lacrimal_gland2.44193436
11MP0002210_abnormal_sex_determination2.30511658
12MP0009384_cardiac_valve_regurgitation2.28369468
13MP0001486_abnormal_startle_reflex2.26682199
14MP0002161_abnormal_fertility/fecundity2.08247499
15MP0004742_abnormal_vestibular_system1.96422497
16MP0003879_abnormal_hair_cell1.89629367
17MP0001145_abnormal_male_reproductive1.79747139
18MP0001986_abnormal_taste_sensitivity1.74725777
19MP0001984_abnormal_olfaction1.74722802
20MP0005379_endocrine/exocrine_gland_phen1.64438608
21MP0000653_abnormal_sex_gland1.61381701
22MP0001963_abnormal_hearing_physiology1.57059104
23MP0003011_delayed_dark_adaptation1.54396936
24MP0005451_abnormal_body_composition1.53859832
25MP0002282_abnormal_trachea_morphology1.44417047
26MP0008877_abnormal_DNA_methylation1.40627649
27MP0005551_abnormal_eye_electrophysiolog1.34817536
28MP0000534_abnormal_ureter_morphology1.34559123
29MP0000026_abnormal_inner_ear1.33542783
30MP0004859_abnormal_synaptic_plasticity1.31649726
31MP0002735_abnormal_chemical_nociception1.31555611
32MP0001968_abnormal_touch/_nociception1.29487444
33MP0003718_maternal_effect1.29023800
34MP0002736_abnormal_nociception_after1.28707370
35MP0009053_abnormal_anal_canal1.26979329
36MP0005171_absent_coat_pigmentation1.21671679
37MP0001958_emphysema1.20806671
38MP0000678_abnormal_parathyroid_gland1.19668942
39MP0002249_abnormal_larynx_morphology1.13405564
40MP0000538_abnormal_urinary_bladder1.11090736
41MP0010329_abnormal_lipoprotein_level1.06269282
42MP0005310_abnormal_salivary_gland1.04797271
43MP0009115_abnormal_fat_cell0.99809714
44MP0005503_abnormal_tendon_morphology0.99522174
45MP0002653_abnormal_ependyma_morphology0.98796687
46MP0005253_abnormal_eye_physiology0.98131681
47MP0002557_abnormal_social/conspecific_i0.96842116
48MP0005332_abnormal_amino_acid0.96385215
49MP0001765_abnormal_ion_homeostasis0.95105579
50MP0002160_abnormal_reproductive_system0.93472261
51MP0000049_abnormal_middle_ear0.91659190
52MP0008438_abnormal_cutaneous_collagen0.90618742
53MP0002067_abnormal_sensory_capabilities0.88120804
54MP0002229_neurodegeneration0.85771827
55MP0000955_abnormal_spinal_cord0.85210280
56MP0003329_amyloid_beta_deposits0.84197635
57MP0009250_abnormal_appendicular_skeleto0.83405999
58MP0002572_abnormal_emotion/affect_behav0.82309174
59MP0005167_abnormal_blood-brain_barrier0.82049638
60MP0001756_abnormal_urination0.80683337
61MP0005408_hypopigmentation0.79113831
62MP0008569_lethality_at_weaning0.78950273
63MP0004233_abnormal_muscle_weight0.75565948
64MP0002234_abnormal_pharynx_morphology0.75341038
65MP0003172_abnormal_lysosome_physiology0.70853475
66MP0005367_renal/urinary_system_phenotyp0.70442374
67MP0000516_abnormal_urinary_system0.70442374
68MP0008004_abnormal_stomach_pH0.69966145
69MP0009780_abnormal_chondrocyte_physiolo0.69228882
70MP0001905_abnormal_dopamine_level0.67951148
71MP0004019_abnormal_vitamin_homeostasis0.67266234
72MP0005666_abnormal_adipose_tissue0.66020305
73MP0003183_abnormal_peptide_metabolism0.65942476
74MP0004272_abnormal_basement_membrane0.65275736
75MP0001270_distended_abdomen0.65226838
76MP0000751_myopathy0.63989001
77MP0002272_abnormal_nervous_system0.63468676
78MP0002932_abnormal_joint_morphology0.62821868
79MP0003631_nervous_system_phenotype0.62761578
80MP0003632_abnormal_nervous_system0.61278366
81MP0001970_abnormal_pain_threshold0.60680294
82MP0002733_abnormal_thermal_nociception0.58676266
83MP0005083_abnormal_biliary_tract0.54990415
84MP0002928_abnormal_bile_duct0.54958887
85MP0003633_abnormal_nervous_system0.54369317
86MP0001666_abnormal_nutrient_absorption0.54238726
87MP0002115_abnormal_skeleton_extremities0.53696676
88MP0001664_abnormal_digestion0.53244473
89MP0001119_abnormal_female_reproductive0.53045203
90MP0003115_abnormal_respiratory_system0.52629634
91MP0000013_abnormal_adipose_tissue0.51789581
92MP0000230_abnormal_systemic_arterial0.51749151
93MP0005595_abnormal_vascular_smooth0.51293843
94MP0005391_vision/eye_phenotype0.49828806
95MP0001501_abnormal_sleep_pattern0.49677438
96MP0000003_abnormal_adipose_tissue0.49127371
97MP0000566_synostosis0.48602457
98MP0000681_abnormal_thyroid_gland0.48413747
99MP0003635_abnormal_synaptic_transmissio0.48363856
100MP0002127_abnormal_cardiovascular_syste0.47498810

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)7.06651947
2Tubulointerstitial nephritis (HP:0001970)6.28668825
3Asymmetric septal hypertrophy (HP:0001670)5.48358620
4Absent/shortened dynein arms (HP:0200106)5.40099382
5Dynein arm defect of respiratory motile cilia (HP:0012255)5.40099382
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.98526407
7Cone-rod dystrophy (HP:0000548)4.29543884
8Nasal polyposis (HP:0100582)4.28571357
9Severe visual impairment (HP:0001141)4.21274259
10Abnormal respiratory motile cilium physiology (HP:0012261)4.19283996
11Attenuation of retinal blood vessels (HP:0007843)4.14203379
12Renovascular hypertension (HP:0100817)4.12385810
13Abnormal ciliary motility (HP:0012262)4.05627401
14Hypoalphalipoproteinemia (HP:0003233)3.99898217
15Male infertility (HP:0003251)3.90032255
16Menstrual irregularities (HP:0000858)3.89083999
17Abnormal respiratory motile cilium morphology (HP:0005938)3.78713222
18Abnormal respiratory epithelium morphology (HP:0012253)3.78713222
19Progressive sensorineural hearing impairment (HP:0000408)3.70129868
20Abnormality of the nasal mucosa (HP:0000433)3.56434828
21Bell-shaped thorax (HP:0001591)3.53274145
22Bony spicule pigmentary retinopathy (HP:0007737)3.47151731
23Abnormality of macular pigmentation (HP:0008002)3.39841810
24Hyperkalemia (HP:0002153)3.37135182
25Resting tremor (HP:0002322)3.27270795
26Stage 5 chronic kidney disease (HP:0003774)3.26144706
27Nephronophthisis (HP:0000090)3.26039875
28Progressive cerebellar ataxia (HP:0002073)3.14634319
29Abnormality of dental color (HP:0011073)3.10407728
30Intellectual disability, moderate (HP:0002342)3.05237519
31Abnormality of the hepatic vasculature (HP:0006707)3.05192608
32Portal hypertension (HP:0001409)3.04579613
33Truncal obesity (HP:0001956)3.01156386
34Infertility (HP:0000789)2.96883949
35Impulsivity (HP:0100710)2.92407825
36Tubulointerstitial abnormality (HP:0001969)2.90530814
37Amelogenesis imperfecta (HP:0000705)2.86721615
38Aplasia/Hypoplasia of the earlobes (HP:0009906)2.82964890
39Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.81335649
40Spontaneous abortion (HP:0005268)2.81253160
41Hypoalbuminemia (HP:0003073)2.76665461
42Abnormal albumin level (HP:0012116)2.76665461
43Abnormality of dentin (HP:0010299)2.68173346
44Occipital encephalocele (HP:0002085)2.63959754
45Rhinitis (HP:0012384)2.63399987
46Tubular atrophy (HP:0000092)2.58066329
47Abnormality of the renal medulla (HP:0100957)2.57644866
48Progressive hearing impairment (HP:0001730)2.51131310
49Enlarged epiphyses (HP:0010580)2.48843706
50Insulin-resistant diabetes mellitus (HP:0000831)2.48462599
51Abnormality of the costochondral junction (HP:0000919)2.47989605
52Decreased central vision (HP:0007663)2.47771944
53Hypoplasia of the thymus (HP:0000778)2.43947367
54Abnormal spermatogenesis (HP:0008669)2.41918753
55Congenital sensorineural hearing impairment (HP:0008527)2.37402733
56Azoospermia (HP:0000027)2.34565878
57Subcapsular cataract (HP:0000523)2.25885635
58Abnormal drinking behavior (HP:0030082)2.24260249
59Polydipsia (HP:0001959)2.24260249
60Hand muscle atrophy (HP:0009130)2.24041925
61Horizontal nystagmus (HP:0000666)2.23403336
62Pancreatic fibrosis (HP:0100732)2.19162900
63Postural instability (HP:0002172)2.18510512
64Hyperuricemia (HP:0002149)2.14740219
65Increased purine levels (HP:0004368)2.14740219
66Focal segmental glomerulosclerosis (HP:0000097)2.14585066
67Increased corneal curvature (HP:0100692)2.11456474
68Keratoconus (HP:0000563)2.11456474
69Bradycardia (HP:0001662)2.11029284
70Chronic bronchitis (HP:0004469)2.09205349
71Hypolipoproteinemia (HP:0010981)2.07404157
72Convex nasal ridge (HP:0000444)2.06582482
73Pendular nystagmus (HP:0012043)2.06426063
74Rectal prolapse (HP:0002035)2.03996567
75True hermaphroditism (HP:0010459)2.03675624
76Hypophosphatemic rickets (HP:0004912)2.03132222
77Delayed epiphyseal ossification (HP:0002663)2.02746325
78Cystic liver disease (HP:0006706)1.99542055
79Obsessive-compulsive behavior (HP:0000722)1.98859311
80Coronal craniosynostosis (HP:0004440)1.95562431
81Upper limb muscle weakness (HP:0003484)1.94618362
82Flattened epiphyses (HP:0003071)1.92987242
83Morphological abnormality of the inner ear (HP:0011390)1.92088611
84Potter facies (HP:0002009)1.91889796
85Facial shape deformation (HP:0011334)1.91889796
86Abnormal urine output (HP:0012590)1.90911660
87Widely patent fontanelles and sutures (HP:0004492)1.89163180
88Distal upper limb amyotrophy (HP:0007149)1.88676204
89Upper limb amyotrophy (HP:0009129)1.88676204
90Flat capital femoral epiphysis (HP:0003370)1.82544040
91Acanthosis nigricans (HP:0000956)1.82200631
92Abnormality of cochlea (HP:0000375)1.75786472
93Thin bony cortex (HP:0002753)1.75496137
94Peritonitis (HP:0002586)1.74798779
95Neonatal short-limb short stature (HP:0008921)1.74492603
96Genetic anticipation (HP:0003743)1.72115177
97Pancreatic cysts (HP:0001737)1.68686700
98Molar tooth sign on MRI (HP:0002419)1.66031852
99Abnormality of midbrain morphology (HP:0002418)1.66031852
100Abnormality of the aortic arch (HP:0012303)1.65802683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.44472237
2INSRR5.55960153
3PLK23.99215896
4BRD43.91658014
5PNCK3.57892956
6MAPK153.11799252
7TESK12.92350017
8STK382.54210826
9STK38L2.46125029
10PIK3CG2.39063524
11CAMK1G2.33876405
12NEK62.23649935
13DDR22.14944161
14PDK22.14670306
15PRKD32.08014126
16TYRO31.97337277
17PDPK11.56191347
18PTK2B1.51492010
19MST1R1.39690543
20PDK11.35602506
21FRK1.27197781
22MAP4K21.27081500
23CDK121.12262166
24MET1.08614017
25WNK11.03142882
26MAP2K20.95128976
27DYRK1B0.92514978
28AKT30.91318003
29WNK40.90513747
30MARK10.83572873
31NEK90.76505344
32NEK20.74145521
33RPS6KA20.74067535
34SIK20.73961941
35CAMK1D0.73737807
36PDGFRA0.71097771
37PRKG20.68845606
38TIE10.68696122
39EPHA40.68146205
40UHMK10.66178729
41CAMK10.63341423
42MUSK0.62712361
43BRSK10.57458818
44CDK70.56876733
45STK390.56693972
46NTRK30.55167361
47EPHA20.51568733
48LMTK20.50501489
49MAP3K110.49812019
50NTRK10.49807221
51MAP3K90.46950058
52BLK0.46367879
53ROCK10.45675644
54PRKCZ0.44333155
55MTOR0.43574285
56BRAF0.43104535
57PRKG10.41868090
58CDK30.36962294
59MAPK10.36305032
60CDK10.35144361
61CAMK40.34312623
62RPS6KC10.34251137
63RPS6KL10.34251137
64RPS6KA60.33869955
65PRKD20.32195713
66CDK20.31938403
67RPS6KA10.31531327
68MAPK70.30935640
69GSK3B0.28968707
70SGK10.28934957
71PRKCG0.28270371
72MAP3K70.27866890
73FGFR20.27119026
74TESK20.26763177
75OXSR10.26072931
76PLK10.26060713
77MAPK80.24568769
78PKN10.23169903
79CASK0.22876084
80ADRBK20.22107737
81NTRK20.21457361
82MAP2K70.21364887
83TRIB30.21165062
84LATS20.20411410
85BCKDK0.19970333
86MAPK140.18242485
87CHEK10.18091130
88MAP3K130.17849786
89PRKAA20.17651237
90SGK4940.17074289
91SGK2230.17074289
92MAPK100.15168581
93PDGFRB0.13813820
94CSNK1A10.13408718
95AKT10.13276279
96CDK11A0.11081308
97PRKACA0.10886894
98ERBB20.10186716
99MAP2K10.10184985
100MAPKAPK50.10171252

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.76222390
2Olfactory transduction_Homo sapiens_hsa047403.54622551
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.44402343
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.53994662
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.19535777
6Fatty acid degradation_Homo sapiens_hsa000712.12748405
7Sulfur relay system_Homo sapiens_hsa041221.91022439
8Taste transduction_Homo sapiens_hsa047421.83175603
9Butanoate metabolism_Homo sapiens_hsa006501.82034333
10ECM-receptor interaction_Homo sapiens_hsa045121.73400984
11Protein digestion and absorption_Homo sapiens_hsa049741.70632080
12Fatty acid metabolism_Homo sapiens_hsa012121.55708219
13Glycerophospholipid metabolism_Homo sapiens_hsa005641.53919479
14Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.51530489
15Phenylalanine metabolism_Homo sapiens_hsa003601.49102101
16ABC transporters_Homo sapiens_hsa020101.47527565
17Calcium signaling pathway_Homo sapiens_hsa040201.42560020
18PPAR signaling pathway_Homo sapiens_hsa033201.39955012
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39600735
20RNA transport_Homo sapiens_hsa030131.39595605
21Glutamatergic synapse_Homo sapiens_hsa047241.38440298
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.37320549
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.37277074
24Dorso-ventral axis formation_Homo sapiens_hsa043201.35911032
25Inositol phosphate metabolism_Homo sapiens_hsa005621.29602274
26Nicotine addiction_Homo sapiens_hsa050331.29199270
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23863133
28Adipocytokine signaling pathway_Homo sapiens_hsa049201.20459179
29Phototransduction_Homo sapiens_hsa047441.18689338
30Glycerolipid metabolism_Homo sapiens_hsa005611.11490806
31Nitrogen metabolism_Homo sapiens_hsa009101.05339831
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.04960379
33Fanconi anemia pathway_Homo sapiens_hsa034601.01631702
34Hedgehog signaling pathway_Homo sapiens_hsa043401.00245274
35Cocaine addiction_Homo sapiens_hsa050300.95946505
36Synaptic vesicle cycle_Homo sapiens_hsa047210.95618874
37cAMP signaling pathway_Homo sapiens_hsa040240.95468156
38Renin-angiotensin system_Homo sapiens_hsa046140.94639452
39Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94190999
40Amphetamine addiction_Homo sapiens_hsa050310.94159213
41Bile secretion_Homo sapiens_hsa049760.91731177
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90980631
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87983171
44Type II diabetes mellitus_Homo sapiens_hsa049300.87793945
45Salivary secretion_Homo sapiens_hsa049700.86483221
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85820613
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85209696
48Arginine and proline metabolism_Homo sapiens_hsa003300.83955111
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81124778
50Circadian entrainment_Homo sapiens_hsa047130.79973680
51Oocyte meiosis_Homo sapiens_hsa041140.78275043
52Thyroid hormone synthesis_Homo sapiens_hsa049180.76651741
53Lysine degradation_Homo sapiens_hsa003100.76429347
54Focal adhesion_Homo sapiens_hsa045100.75713657
55Estrogen signaling pathway_Homo sapiens_hsa049150.73904592
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.71637900
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70394346
58Tyrosine metabolism_Homo sapiens_hsa003500.69737364
59Gastric acid secretion_Homo sapiens_hsa049710.68427387
60Tryptophan metabolism_Homo sapiens_hsa003800.67725602
61mTOR signaling pathway_Homo sapiens_hsa041500.65694129
62beta-Alanine metabolism_Homo sapiens_hsa004100.63189598
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62697888
64Base excision repair_Homo sapiens_hsa034100.62696764
65Retinol metabolism_Homo sapiens_hsa008300.62511405
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60729744
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59663086
68Sphingolipid metabolism_Homo sapiens_hsa006000.59138798
69Arginine biosynthesis_Homo sapiens_hsa002200.58846025
70Notch signaling pathway_Homo sapiens_hsa043300.57470660
71Fat digestion and absorption_Homo sapiens_hsa049750.57285013
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55136489
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54340946
74Morphine addiction_Homo sapiens_hsa050320.54131598
75VEGF signaling pathway_Homo sapiens_hsa043700.54124678
76Renin secretion_Homo sapiens_hsa049240.54026817
77Selenocompound metabolism_Homo sapiens_hsa004500.53711703
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53093348
79Insulin secretion_Homo sapiens_hsa049110.52996978
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52427088
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49298244
82Long-term potentiation_Homo sapiens_hsa047200.49008545
83Endocytosis_Homo sapiens_hsa041440.48567147
84Cholinergic synapse_Homo sapiens_hsa047250.46839588
85Biosynthesis of amino acids_Homo sapiens_hsa012300.46507735
86Vitamin digestion and absorption_Homo sapiens_hsa049770.45042009
87Pancreatic secretion_Homo sapiens_hsa049720.44733258
88Homologous recombination_Homo sapiens_hsa034400.44488954
89GABAergic synapse_Homo sapiens_hsa047270.42661684
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40823092
91Chemical carcinogenesis_Homo sapiens_hsa052040.39921426
92Propanoate metabolism_Homo sapiens_hsa006400.38726550
93Glucagon signaling pathway_Homo sapiens_hsa049220.37956481
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37009422
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36790430
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.36419847
97Serotonergic synapse_Homo sapiens_hsa047260.36362978
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35642047
99Nucleotide excision repair_Homo sapiens_hsa034200.34490880
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34079515

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