C9ORF84

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)6.43129307
2microglial cell activation (GO:0001774)5.66254952
3protein K11-linked deubiquitination (GO:0035871)5.29737297
4establishment of protein localization to Golgi (GO:0072600)5.26153433
5protein targeting to Golgi (GO:0000042)5.06440207
6positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.99309805
7histone H3-K36 demethylation (GO:0070544)4.83645375
8phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.82645167
9histone mRNA catabolic process (GO:0071044)4.73781417
10retrograde transport, vesicle recycling within Golgi (GO:0000301)4.71759287
11positive regulation by symbiont of host defense response (GO:0052509)4.70066519
12modulation by symbiont of host defense response (GO:0052031)4.70066519
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.70066519
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.70066519
15positive regulation by organism of defense response of other organism involved in symbiotic interact4.70066519
16modulation by symbiont of host immune response (GO:0052553)4.70066519
17neural tube formation (GO:0001841)4.48375011
18histone H3-K9 demethylation (GO:0033169)4.31249400
19monoubiquitinated protein deubiquitination (GO:0035520)4.26668928
20negative regulation of complement activation (GO:0045916)4.24223932
21macrophage activation (GO:0042116)4.09874329
22regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.08866813
23myeloid leukocyte mediated immunity (GO:0002444)4.07271155
24synapsis (GO:0007129)4.06446201
25regulation of B cell receptor signaling pathway (GO:0050855)4.02990999
26macrophage activation involved in immune response (GO:0002281)4.01886188
27hepatocyte apoptotic process (GO:0097284)3.99912529
28protein K48-linked deubiquitination (GO:0071108)3.95773433
29male meiosis I (GO:0007141)3.94928514
30positive regulation of gamma-delta T cell activation (GO:0046645)3.80079528
31neutrophil mediated immunity (GO:0002446)3.79620724
32cellular response to ethanol (GO:0071361)3.78210368
33regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.77930420
34positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.77535376
35negative regulation of protein activation cascade (GO:2000258)3.70090626
36negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.70058358
37negative regulation of B cell mediated immunity (GO:0002713)3.68933348
38negative regulation of immunoglobulin mediated immune response (GO:0002890)3.68933348
39detection of external biotic stimulus (GO:0098581)3.65102230
40piRNA metabolic process (GO:0034587)3.61654839
41positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.51200059
42mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.49623111
43positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.49623111
44protein K63-linked deubiquitination (GO:0070536)3.47269511
45negative regulation of B cell proliferation (GO:0030889)3.42390057
46response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.41713264
47response to host immune response (GO:0052572)3.41713264
48negative regulation of humoral immune response (GO:0002921)3.41062876
49negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.36599733
50cilium or flagellum-dependent cell motility (GO:0001539)3.35080589
51early endosome to late endosome transport (GO:0045022)3.34635347
52protein localization to Golgi apparatus (GO:0034067)3.33462356
53macroautophagy (GO:0016236)3.30283244
54negative regulation of cell killing (GO:0031342)3.25372418
55negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.25372418
56regulation of interferon-beta biosynthetic process (GO:0045357)3.22501585
57protein targeting to vacuole (GO:0006623)3.19560801
58protein targeting to lysosome (GO:0006622)3.19560801
59establishment of protein localization to vacuole (GO:0072666)3.19560801
60iron ion import (GO:0097286)3.18764528
61chromosome organization involved in meiosis (GO:0070192)3.13808604
62histone H3-K4 trimethylation (GO:0080182)3.12516233
63phospholipid homeostasis (GO:0055091)3.11946230
64interkinetic nuclear migration (GO:0022027)3.10823627
65regulation of beta-amyloid formation (GO:1902003)3.09064940
66response to host (GO:0075136)3.08192142
67response to host defenses (GO:0052200)3.08192142
68response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.08192142
69detection of biotic stimulus (GO:0009595)3.07710536
70cellular extravasation (GO:0045123)3.07658473
71male meiosis (GO:0007140)3.06349042
72regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.04731869
73mitochondrion distribution (GO:0048311)3.04708118
74positive regulation of insulin receptor signaling pathway (GO:0046628)3.02843567
75epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.00564706
76negative regulation of inclusion body assembly (GO:0090084)3.00160977
77regulation of interleukin-6 biosynthetic process (GO:0045408)2.94756248
78negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.93605846
79negative regulation of neurotransmitter transport (GO:0051589)2.91927179
80regulation of MHC class I biosynthetic process (GO:0045343)2.89823710
81DNA methylation involved in gamete generation (GO:0043046)2.87952198
82positive regulation of granulocyte differentiation (GO:0030854)2.86924668
83dosage compensation (GO:0007549)2.85577341
84peptidyl-lysine trimethylation (GO:0018023)2.83768127
85meiosis I (GO:0007127)2.82835733
86synaptonemal complex assembly (GO:0007130)2.82536808
87negative regulation of lymphocyte mediated immunity (GO:0002707)2.81427857
88natural killer cell activation involved in immune response (GO:0002323)2.80563338
89production of molecular mediator involved in inflammatory response (GO:0002532)2.77533665
90intra-Golgi vesicle-mediated transport (GO:0006891)2.77117229
91reciprocal meiotic recombination (GO:0007131)2.75213013
92reciprocal DNA recombination (GO:0035825)2.75213013
93histone lysine demethylation (GO:0070076)2.74233711
94leukotriene biosynthetic process (GO:0019370)2.73557642
95histone-serine phosphorylation (GO:0035404)2.70804725
96regulation of interleukin-12 biosynthetic process (GO:0045075)2.70791959
97negative regulation of T cell mediated immunity (GO:0002710)2.68687847
98regulation of meiosis I (GO:0060631)2.68161301
99sister chromatid cohesion (GO:0007062)2.66989544
100regulation of gamma-delta T cell activation (GO:0046643)2.66561786

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.25716591
2CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.02093272
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.94752637
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.89231392
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.86596763
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.85406687
7TAF15_26573619_Chip-Seq_HEK293_Human2.35237289
8GBX2_23144817_ChIP-Seq_PC3_Human2.35062990
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.30887941
10IGF1R_20145208_ChIP-Seq_DFB_Human2.25950112
11AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.24361498
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.23661570
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.13214210
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.08780206
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.03390919
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00090607
17* ER_23166858_ChIP-Seq_MCF-7_Human1.97977693
18IRF8_22096565_ChIP-ChIP_GC-B_Human1.85889951
19P300_19829295_ChIP-Seq_ESCs_Human1.85797326
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84361075
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80553029
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.76419029
23MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.70708926
24* STAT3_23295773_ChIP-Seq_U87_Human1.70584247
25FUS_26573619_Chip-Seq_HEK293_Human1.69897903
26SMAD4_21799915_ChIP-Seq_A2780_Human1.68982469
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63797649
28OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63072389
29ZNF274_21170338_ChIP-Seq_K562_Hela1.60067800
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.59485479
31TP53_16413492_ChIP-PET_HCT116_Human1.59060710
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58918956
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56897650
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56606096
35EZH2_27294783_Chip-Seq_NPCs_Mouse1.56138564
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.53954925
37NANOG_18555785_Chip-Seq_ESCs_Mouse1.51590210
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.49394115
39RUNX_20019798_ChIP-Seq_JUKART_Human1.49373803
40POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.48084987
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48084987
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47791160
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.47219415
44* TCF4_23295773_ChIP-Seq_U87_Human1.46912143
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44988312
46CBP_20019798_ChIP-Seq_JUKART_Human1.44988312
47VDR_22108803_ChIP-Seq_LS180_Human1.44782508
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44298667
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44035493
50CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.43858401
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42062768
52TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.41097692
53PRDM14_20953172_ChIP-Seq_ESCs_Human1.40026728
54* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.37884291
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37634271
56BCAT_22108803_ChIP-Seq_LS180_Human1.36260496
57IRF8_27001747_Chip-Seq_BMDM_Mouse1.35984107
58AR_25329375_ChIP-Seq_VCAP_Human1.35230618
59EWS_26573619_Chip-Seq_HEK293_Human1.33969866
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33850498
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.33708541
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33256463
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33133146
64FLI1_21867929_ChIP-Seq_TH2_Mouse1.32770341
65IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31735505
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31163161
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30754056
68E2F1_18555785_Chip-Seq_ESCs_Mouse1.29500600
69AR_21572438_ChIP-Seq_LNCaP_Human1.28543110
70PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27586777
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.25937158
72P53_22387025_ChIP-Seq_ESCs_Mouse1.24015859
73* RUNX2_22187159_ChIP-Seq_PCA_Human1.22905880
74VDR_24787735_ChIP-Seq_THP-1_Human1.22139010
75CMYC_18555785_Chip-Seq_ESCs_Mouse1.21227641
76* CDX2_22108803_ChIP-Seq_LS180_Human1.20552337
77CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18200767
78SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17654528
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17278541
80ESR1_20079471_ChIP-ChIP_T-47D_Human1.15053742
81GATA1_22025678_ChIP-Seq_K562_Human1.13540288
82OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13490413
83AHR_22903824_ChIP-Seq_MCF-7_Human1.13413216
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.13063917
85TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12883734
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.12707908
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11022181
88FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10857192
89* TP63_23658742_ChIP-Seq_EP156T_Human1.09792333
90P300_18555785_Chip-Seq_ESCs_Mouse1.08968053
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07096324
92SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06598592
93* SMAD4_21741376_ChIP-Seq_EPCs_Human1.05618376
94TCF4_22108803_ChIP-Seq_LS180_Human1.04910091
95FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04900143
96IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04453233
97GATA3_26560356_Chip-Seq_TH2_Human1.03821777
98EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02154501
99KDM2B_26808549_Chip-Seq_REH_Human1.01807419
100OCT4_18555785_Chip-Seq_ESCs_Mouse1.01378453

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation8.66351482
2MP0008877_abnormal_DNA_methylation5.85706360
3MP0003787_abnormal_imprinting4.38330987
4MP0008260_abnormal_autophagy4.23686046
5MP0008057_abnormal_DNA_replication3.85954507
6MP0003724_increased_susceptibility_to3.64522594
7MP0003656_abnormal_erythrocyte_physiolo2.62066621
8MP0000427_abnormal_hair_cycle2.37805894
9MP0005174_abnormal_tail_pigmentation2.26975348
10MP0004381_abnormal_hair_follicle2.22412083
11MP0000015_abnormal_ear_pigmentation2.18850509
12MP0004883_abnormal_blood_vessel2.15520352
13MP0003121_genomic_imprinting2.14549612
14MP0004484_altered_response_of2.14246365
15MP0003221_abnormal_cardiomyocyte_apopto2.07229436
16MP0002166_altered_tumor_susceptibility1.93148681
17MP0003195_calcinosis1.91757741
18MP0005310_abnormal_salivary_gland1.85074438
19MP0001835_abnormal_antigen_presentation1.73047536
20MP0003828_pulmonary_edema1.70159404
21MP0008995_early_reproductive_senescence1.62956150
22MP0003172_abnormal_lysosome_physiology1.61858795
23MP0005075_abnormal_melanosome_morpholog1.58137311
24MP0003183_abnormal_peptide_metabolism1.56844482
25MP0003950_abnormal_plasma_membrane1.54158436
26MP0006054_spinal_hemorrhage1.39966301
27MP0000383_abnormal_hair_follicle1.39641676
28MP0005164_abnormal_response_to1.37147763
29MP0002332_abnormal_exercise_endurance1.36522416
30MP0001800_abnormal_humoral_immune1.31376953
31MP0000371_diluted_coat_color1.24935988
32MP0002006_tumorigenesis1.21472650
33MP0002928_abnormal_bile_duct1.18948778
34MP0002909_abnormal_adrenal_gland1.17698933
35MP0008004_abnormal_stomach_pH1.16625660
36MP0010678_abnormal_skin_adnexa1.14343496
37MP0001929_abnormal_gametogenesis1.07779390
38MP0002419_abnormal_innate_immunity1.02804019
39MP0000685_abnormal_immune_system1.01454556
40MP0003763_abnormal_thymus_physiology1.01282264
41MP0005376_homeostasis/metabolism_phenot0.99681845
42MP0003690_abnormal_glial_cell0.98871767
43MP0005389_reproductive_system_phenotype0.98729481
44MP0005408_hypopigmentation0.97292241
45MP0003890_abnormal_embryonic-extraembry0.96521458
46MP0002095_abnormal_skin_pigmentation0.93242999
47MP0002723_abnormal_immune_serum0.92894393
48MP0000647_abnormal_sebaceous_gland0.90892772
49MP0003646_muscle_fatigue0.86915374
50MP0002210_abnormal_sex_determination0.86861076
51MP0003632_abnormal_nervous_system0.86640985
52MP0005266_abnormal_metabolism0.85735193
53MP0004130_abnormal_muscle_cell0.85141442
54MP0003045_fibrosis0.83775575
55MP0003698_abnormal_male_reproductive0.83767174
56MP0002009_preneoplasia0.83595378
57MP0001958_emphysema0.83538964
58MP0009785_altered_susceptibility_to0.83478531
59MP0002452_abnormal_antigen_presenting0.82293613
60MP0005451_abnormal_body_composition0.81425792
61MP0000689_abnormal_spleen_morphology0.80397722
62MP0002420_abnormal_adaptive_immunity0.80335286
63MP0001819_abnormal_immune_cell0.79218924
64MP0002405_respiratory_system_inflammati0.77989821
65MP0001119_abnormal_female_reproductive0.77652624
66MP0000653_abnormal_sex_gland0.77599081
67MP0004043_abnormal_pH_regulation0.75603035
68MP0001851_eye_inflammation0.75116226
69MP0001986_abnormal_taste_sensitivity0.74863797
70MP0002168_other_aberrant_phenotype0.74656759
71MP0004808_abnormal_hematopoietic_stem0.74314686
72MP0002160_abnormal_reproductive_system0.74226649
73MP0003786_premature_aging0.73729156
74MP0005187_abnormal_penis_morphology0.73189433
75MP0002396_abnormal_hematopoietic_system0.70536334
76MP0001145_abnormal_male_reproductive0.70086343
77MP0010307_abnormal_tumor_latency0.69416889
78MP0002722_abnormal_immune_system0.69166880
79MP0003122_maternal_imprinting0.68831808
80MP0005397_hematopoietic_system_phenotyp0.68405527
81MP0001545_abnormal_hematopoietic_system0.68405527
82MP0005025_abnormal_response_to0.67943432
83MP0008058_abnormal_DNA_repair0.67529283
84MP0000465_gastrointestinal_hemorrhage0.66718412
85MP0002277_abnormal_respiratory_mucosa0.65846886
86MP0000716_abnormal_immune_system0.65541764
87MP0002102_abnormal_ear_morphology0.64798388
88MP0002398_abnormal_bone_marrow0.64587256
89MP0003303_peritoneal_inflammation0.64565263
90MP0001984_abnormal_olfaction0.62465921
91MP0002132_abnormal_respiratory_system0.62033858
92MP0009764_decreased_sensitivity_to0.61995090
93MP0003252_abnormal_bile_duct0.60866153
94MP0002163_abnormal_gland_morphology0.60497059
95MP0003091_abnormal_cell_migration0.60296067
96MP0001919_abnormal_reproductive_system0.59485217
97MP0000703_abnormal_thymus_morphology0.58388320
98MP0005671_abnormal_response_to0.56109346
99MP0004742_abnormal_vestibular_system0.55269422
100MP0004142_abnormal_muscle_tone0.55016570

Predicted human phenotypes

RankGene SetZ-score
1Parkinsonism with favorable response to dopaminergic medication (HP:0002548)6.66496262
2Recurrent bacterial skin infections (HP:0005406)4.05696790
3T lymphocytopenia (HP:0005403)3.96862802
4Abnormality of T cell number (HP:0011839)3.84091498
5Optic neuritis (HP:0100653)3.62736101
6Retrobulbar optic neuritis (HP:0100654)3.62736101
7Volvulus (HP:0002580)3.35420245
8Papillary thyroid carcinoma (HP:0002895)3.32644559
9Recurrent abscess formation (HP:0002722)3.25910451
10Tubulointerstitial nephritis (HP:0001970)3.18810854
11Orchitis (HP:0100796)3.17128790
12Postural instability (HP:0002172)3.16716174
13Myositis (HP:0100614)3.08663451
14Peritonitis (HP:0002586)3.07821650
15Gastrointestinal infarctions (HP:0005244)3.00137961
16Keratoconjunctivitis sicca (HP:0001097)2.86953331
17Gaze-evoked nystagmus (HP:0000640)2.84877402
18Genetic anticipation (HP:0003743)2.82735561
19Keratoconjunctivitis (HP:0001096)2.74083944
20Gingivitis (HP:0000230)2.73147279
21Degeneration of the lateral corticospinal tracts (HP:0002314)2.70860493
22Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.70860493
23Dynein arm defect of respiratory motile cilia (HP:0012255)2.69717086
24Absent/shortened dynein arms (HP:0200106)2.69717086
25Resting tremor (HP:0002322)2.65090386
26Gingival bleeding (HP:0000225)2.63590792
27Chronic hepatic failure (HP:0100626)2.63295247
28Febrile seizures (HP:0002373)2.59585936
29Pancreatic cysts (HP:0001737)2.55801253
30Recurrent skin infections (HP:0001581)2.54947915
31Truncal obesity (HP:0001956)2.50402385
32Widely spaced teeth (HP:0000687)2.48297611
33Chronic mucocutaneous candidiasis (HP:0002728)2.44478963
34Recurrent cutaneous fungal infections (HP:0011370)2.44478963
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.44052711
36Recurrent fungal infections (HP:0002841)2.42608236
37Subacute progressive viral hepatitis (HP:0006572)2.41595609
38Periodontitis (HP:0000704)2.40032838
39Recurrent gram-negative bacterial infections (HP:0005420)2.39441724
40Thyroiditis (HP:0100646)2.35989602
41Hip dysplasia (HP:0001385)2.35491424
42Amyotrophic lateral sclerosis (HP:0007354)2.35136907
43Spontaneous hematomas (HP:0007420)2.34399308
44Arterial thrombosis (HP:0004420)2.30442492
45Oligodactyly (hands) (HP:0001180)2.29968024
46True hermaphroditism (HP:0010459)2.27226634
47Eczematoid dermatitis (HP:0000976)2.25412160
48Slow saccadic eye movements (HP:0000514)2.25304892
49Progressive cerebellar ataxia (HP:0002073)2.23769133
50Abnormality of the renal medulla (HP:0100957)2.20099154
51Pancreatic fibrosis (HP:0100732)2.19501881
52Abnormality of the renal cortex (HP:0011035)2.17892218
53Conjunctival telangiectasia (HP:0000524)2.14431203
54Thyroid carcinoma (HP:0002890)2.14013131
55Fair hair (HP:0002286)2.13873586
56Facial diplegia (HP:0001349)2.11418885
57Abnormality of T cells (HP:0002843)2.09493589
58Recurrent bronchitis (HP:0002837)2.06662920
59Portal hypertension (HP:0001409)2.06148630
60Nephronophthisis (HP:0000090)1.98806054
61Abnormality of the vasculature of the conjunctiva (HP:0008054)1.98141880
62Hypoplasia of the thymus (HP:0000778)1.97347993
63Pelvic girdle muscle weakness (HP:0003749)1.96452327
64Abnormality of the musculature of the pelvis (HP:0001469)1.92595741
65Abnormality of the hip-girdle musculature (HP:0001445)1.92595741
66Abnormal ciliary motility (HP:0012262)1.92173142
67Neoplasm of the tracheobronchial system (HP:0100552)1.90788175
68Leukocytosis (HP:0001974)1.90047226
69Aqueductal stenosis (HP:0002410)1.89483573
70Abnormality of chromosome stability (HP:0003220)1.88016697
71Stomach cancer (HP:0012126)1.87637677
72Generalized hypopigmentation of hair (HP:0011358)1.86760048
73Stomatitis (HP:0010280)1.85762336
74Abnormality of the hepatic vasculature (HP:0006707)1.84815676
75Abnormality of the corticospinal tract (HP:0002492)1.84549288
76Neurodegeneration (HP:0002180)1.82701406
77Spontaneous abortion (HP:0005268)1.82577366
78Hyperventilation (HP:0002883)1.81532209
79Acute hepatic failure (HP:0006554)1.81292285
80Absent speech (HP:0001344)1.79856325
81Acute myeloid leukemia (HP:0004808)1.77967344
82Medial flaring of the eyebrow (HP:0010747)1.75755537
83Elevated erythrocyte sedimentation rate (HP:0003565)1.74334556
84Poikilocytosis (HP:0004447)1.73625805
85Glucose intolerance (HP:0000833)1.73579327
86Progressive inability to walk (HP:0002505)1.73567359
87Urinary bladder sphincter dysfunction (HP:0002839)1.72326177
88Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72270733
89Keratitis (HP:0000491)1.72046989
90Tubulointerstitial abnormality (HP:0001969)1.72044875
91Gonadotropin excess (HP:0000837)1.71265889
92Visual hallucinations (HP:0002367)1.71175117
93Testicular neoplasm (HP:0010788)1.71059201
94Hyperkalemia (HP:0002153)1.67536910
95Low anterior hairline (HP:0000294)1.67281212
96Rhabdomyosarcoma (HP:0002859)1.66648557
97Hemoptysis (HP:0002105)1.66365084
98Viral hepatitis (HP:0006562)1.65579061
99Encephalitis (HP:0002383)1.65530407
100Abnormal respiratory epithelium morphology (HP:0012253)1.65281379

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.38595833
2ACVR1B2.56753796
3BLK2.49888548
4FGR2.36446328
5PIK3CG2.21878975
6PLK22.11810815
7SGK22.10918937
8PTK2B2.09602006
9MAP3K22.07535200
10CAMKK22.02191234
11TAOK31.93022231
12BMPR1B1.87261534
13WNK11.86858570
14NLK1.84031941
15IKBKE1.67842391
16GRK61.65203206
17AKT31.63951247
18IRAK11.48215621
19IRAK41.48169466
20MAP3K61.45816684
21WNK31.44793172
22CSK1.40829971
23FGFR31.35138359
24PNCK1.34211633
25STK41.32971009
26ERBB21.29373687
27SGK31.29315198
28RIPK41.28548748
29GRK51.24718965
30MAP2K31.24137147
31OXSR11.23429296
32PAK31.23159172
33STK38L1.22409648
34TXK1.22379904
35JAK31.21273706
36MELK1.20811938
37INSRR1.20610972
38MAP3K41.19066383
39YES11.18808522
40SGK4941.17283682
41SGK2231.17283682
42NUAK11.17275100
43KSR11.16278361
44TEC1.09447044
45JAK11.08339055
46CAMK1G1.06340629
47BRD41.04631817
48TNIK0.97773392
49MAP4K20.96388834
50CDK190.94902453
51MAP3K50.94434682
52DYRK1A0.93739326
53SYK0.91324377
54BMPR20.88680607
55STK110.86028331
56NEK90.85921174
57IRAK20.85852707
58MAP2K40.84514103
59DYRK30.84416231
60JAK20.83873782
61SGK10.82693237
62TRPM70.82471731
63TRIM280.82357699
64ADRBK10.81315564
65BTK0.80547069
66BCR0.80112261
67TYK20.79432276
68EGFR0.77181864
69MARK30.76782588
70CAMK40.76049634
71PIM10.75988183
72FGFR20.75804168
73MAPK130.73180556
74NTRK30.71461738
75STK380.69771370
76FES0.69407325
77MARK20.67361712
78HCK0.65860523
79LYN0.63608724
80MUSK0.62552136
81ITK0.61752324
82CAMK1D0.60763499
83TGFBR20.60143445
84PINK10.58904120
85RET0.58382213
86RAF10.56534265
87MAP3K140.55140262
88BRSK20.53000902
89PRKAA20.52109031
90PDGFRB0.48740635
91STK390.48201163
92NEK60.48001300
93CHUK0.41220163
94LCK0.40977593
95STK240.40794979
96ERBB30.40332315
97CSF1R0.39346006
98MAP3K70.39161728
99PIK3CA0.38917195
100MAP3K10.38587567

Predicted pathways (KEGG)

RankGene SetZ-score
1Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.68180696
2Dorso-ventral axis formation_Homo sapiens_hsa043202.41662684
3NOD-like receptor signaling pathway_Homo sapiens_hsa046212.17424982
4Leishmaniasis_Homo sapiens_hsa051401.84359981
5Legionellosis_Homo sapiens_hsa051341.74269582
6Osteoclast differentiation_Homo sapiens_hsa043801.68770513
7FoxO signaling pathway_Homo sapiens_hsa040681.64699841
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.62426413
9Phosphatidylinositol signaling system_Homo sapiens_hsa040701.57677950
10Non-small cell lung cancer_Homo sapiens_hsa052231.57338353
11Inositol phosphate metabolism_Homo sapiens_hsa005621.55677423
12Tuberculosis_Homo sapiens_hsa051521.50811438
13Jak-STAT signaling pathway_Homo sapiens_hsa046301.47606819
14B cell receptor signaling pathway_Homo sapiens_hsa046621.46681021
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.41098315
16Fatty acid biosynthesis_Homo sapiens_hsa000611.39705918
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.36333517
18Circadian rhythm_Homo sapiens_hsa047101.35847518
19Regulation of autophagy_Homo sapiens_hsa041401.35574156
20T cell receptor signaling pathway_Homo sapiens_hsa046601.30451092
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29730179
22Prolactin signaling pathway_Homo sapiens_hsa049171.27671679
23Taste transduction_Homo sapiens_hsa047421.27304259
24Measles_Homo sapiens_hsa051621.25841813
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.23075162
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21008235
27mTOR signaling pathway_Homo sapiens_hsa041501.13221609
28Platelet activation_Homo sapiens_hsa046111.10538094
29Staphylococcus aureus infection_Homo sapiens_hsa051501.05081342
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04665186
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04075744
32Chemokine signaling pathway_Homo sapiens_hsa040620.99122704
33Malaria_Homo sapiens_hsa051440.98614592
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95419565
35ABC transporters_Homo sapiens_hsa020100.94452485
36Endometrial cancer_Homo sapiens_hsa052130.93038990
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90204318
38Renin secretion_Homo sapiens_hsa049240.90029615
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89325514
40Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89106345
41Toxoplasmosis_Homo sapiens_hsa051450.88955007
42Hepatitis B_Homo sapiens_hsa051610.85702205
43Pancreatic cancer_Homo sapiens_hsa052120.84591736
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82535434
45Renal cell carcinoma_Homo sapiens_hsa052110.82160375
46Homologous recombination_Homo sapiens_hsa034400.81513289
47Non-homologous end-joining_Homo sapiens_hsa034500.81467098
48TNF signaling pathway_Homo sapiens_hsa046680.81044987
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80943482
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80477046
51Influenza A_Homo sapiens_hsa051640.80015896
52Basal transcription factors_Homo sapiens_hsa030220.78101296
53Cholinergic synapse_Homo sapiens_hsa047250.77063840
54Type II diabetes mellitus_Homo sapiens_hsa049300.75791308
55Choline metabolism in cancer_Homo sapiens_hsa052310.74728576
56p53 signaling pathway_Homo sapiens_hsa041150.74490688
57Olfactory transduction_Homo sapiens_hsa047400.74401967
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74381393
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74122162
60Hematopoietic cell lineage_Homo sapiens_hsa046400.72178070
61Fanconi anemia pathway_Homo sapiens_hsa034600.71614271
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.70997048
63Hepatitis C_Homo sapiens_hsa051600.70835906
64Long-term potentiation_Homo sapiens_hsa047200.70718281
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69403969
66Prostate cancer_Homo sapiens_hsa052150.68960182
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68648643
68Propanoate metabolism_Homo sapiens_hsa006400.68083010
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.66424142
70Nicotine addiction_Homo sapiens_hsa050330.66235833
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65979186
72Serotonergic synapse_Homo sapiens_hsa047260.65864162
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.62782489
74HIF-1 signaling pathway_Homo sapiens_hsa040660.61244683
75Morphine addiction_Homo sapiens_hsa050320.60965757
76Renin-angiotensin system_Homo sapiens_hsa046140.60266585
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.60182371
78Insulin resistance_Homo sapiens_hsa049310.59794166
79Glutamatergic synapse_Homo sapiens_hsa047240.59687667
80Glioma_Homo sapiens_hsa052140.59652323
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59014993
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58395558
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58250184
84Oocyte meiosis_Homo sapiens_hsa041140.57830784
85Long-term depression_Homo sapiens_hsa047300.57436476
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56685363
87cAMP signaling pathway_Homo sapiens_hsa040240.56652813
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56176179
89Calcium signaling pathway_Homo sapiens_hsa040200.55782331
90MAPK signaling pathway_Homo sapiens_hsa040100.55423027
91Ether lipid metabolism_Homo sapiens_hsa005650.55327129
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.55156863
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.54573442
94Apoptosis_Homo sapiens_hsa042100.53321111
95ErbB signaling pathway_Homo sapiens_hsa040120.53312724
96Oxytocin signaling pathway_Homo sapiens_hsa049210.52667538
97Ras signaling pathway_Homo sapiens_hsa040140.52615185
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51616611
99TGF-beta signaling pathway_Homo sapiens_hsa043500.50932419
100Adherens junction_Homo sapiens_hsa045200.50846172

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