C9ORF91

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.85108066
2negative regulation of cell killing (GO:0031342)4.38505110
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.38505110
4macrophage activation involved in immune response (GO:0002281)4.02370160
5regulation of B cell receptor signaling pathway (GO:0050855)3.99993606
6type I interferon signaling pathway (GO:0060337)3.95304701
7cellular response to type I interferon (GO:0071357)3.95304701
8response to type I interferon (GO:0034340)3.93084036
9immunoglobulin mediated immune response (GO:0016064)3.91529273
10regulation of gamma-delta T cell activation (GO:0046643)3.91083620
11B cell receptor signaling pathway (GO:0050853)3.81178971
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.63521250
13antigen processing and presentation of endogenous antigen (GO:0019883)3.63108204
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.61420547
15interferon-gamma-mediated signaling pathway (GO:0060333)3.61318494
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.56769406
17defense response to protozoan (GO:0042832)3.51490225
18negative regulation of interleukin-12 production (GO:0032695)3.49578757
19positive regulation by symbiont of host defense response (GO:0052509)3.48495582
20modulation by symbiont of host defense response (GO:0052031)3.48495582
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.48495582
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.48495582
23positive regulation by organism of defense response of other organism involved in symbiotic interact3.48495582
24modulation by symbiont of host immune response (GO:0052553)3.48495582
25positive regulation of type 2 immune response (GO:0002830)3.48081643
26negative regulation of T cell mediated immunity (GO:0002710)3.42878450
27regulation of T-helper 1 cell differentiation (GO:0045625)3.38544430
28positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.34418612
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.27053288
30response to protozoan (GO:0001562)3.21107518
31regulation of antigen processing and presentation (GO:0002577)3.15877314
32regulation of gamma-delta T cell differentiation (GO:0045586)3.12392641
33germinal center formation (GO:0002467)3.11377492
34regulation of interferon-beta biosynthetic process (GO:0045357)3.09761856
35regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.09436809
36positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.07541965
37regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.07400067
38synaptic vesicle maturation (GO:0016188)3.06851172
39response to peptidoglycan (GO:0032494)3.05134519
40regulation of dendritic cell antigen processing and presentation (GO:0002604)2.99809485
41T-helper 1 type immune response (GO:0042088)2.96342469
42positive regulation of antigen processing and presentation (GO:0002579)2.93455567
43regulation of T-helper cell differentiation (GO:0045622)2.86931301
44B cell mediated immunity (GO:0019724)2.86775098
45interferon-gamma secretion (GO:0072643)2.86236151
46regulation of T-helper 2 cell differentiation (GO:0045628)2.85773998
47NIK/NF-kappaB signaling (GO:0038061)2.82919926
48positive regulation of mast cell activation (GO:0033005)2.82574128
49synaptic vesicle exocytosis (GO:0016079)2.82080954
50neutrophil activation involved in immune response (GO:0002283)2.80572584
51regulation of interferon-alpha production (GO:0032647)2.78250726
52positive regulation of T-helper cell differentiation (GO:0045624)2.77698418
53positive thymic T cell selection (GO:0045059)2.77683548
54regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.77565589
55myeloid cell activation involved in immune response (GO:0002275)2.77373752
56regulation of ARF protein signal transduction (GO:0032012)2.76546789
57negative regulation of lymphocyte mediated immunity (GO:0002707)2.76132431
58regulation of type 2 immune response (GO:0002828)2.74796576
59T cell migration (GO:0072678)2.74618218
60positive regulation of mast cell degranulation (GO:0043306)2.73824508
61positive regulation of mast cell activation involved in immune response (GO:0033008)2.73824508
62regulation of T cell mediated cytotoxicity (GO:0001914)2.73374786
63response to host immune response (GO:0052572)2.72905552
64response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.72905552
65CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.70704383
66positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.66205121
67positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.65459971
68detection of other organism (GO:0098543)2.64931525
69regulation of MHC class I biosynthetic process (GO:0045343)2.64836143
70regulation of interleukin-12 production (GO:0032655)2.64262057
71T cell selection (GO:0045058)2.64229840
72positive regulation of interferon-alpha production (GO:0032727)2.63915092
73B cell homeostasis (GO:0001782)2.62857260
74thymic T cell selection (GO:0045061)2.62829691
75regulation of mast cell degranulation (GO:0043304)2.61486988
76detection of bacterium (GO:0016045)2.61416806
77negative regulation of leukocyte mediated immunity (GO:0002704)2.61097393
78cellular response to interferon-gamma (GO:0071346)2.60510884
79lipopolysaccharide-mediated signaling pathway (GO:0031663)2.58215639
80positive regulation of Rap GTPase activity (GO:0032854)2.57702613
81positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.57004991
82positive regulation of humoral immune response (GO:0002922)2.56972005
83positive regulation of defense response to virus by host (GO:0002230)2.56630728
84negative thymic T cell selection (GO:0045060)2.56309695
85positive regulation of B cell differentiation (GO:0045579)2.54517238
86myeloid dendritic cell differentiation (GO:0043011)2.53669752
87regulation of alpha-beta T cell proliferation (GO:0046640)2.53227648
88positive regulation of interleukin-12 production (GO:0032735)2.52533796
89response to muramyl dipeptide (GO:0032495)2.52469035
90positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.51548950
91regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.50654067
92regulation of regulated secretory pathway (GO:1903305)2.50643338
93regulation of interleukin-2 biosynthetic process (GO:0045076)2.50613719
94regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.50468512
95cellular response to exogenous dsRNA (GO:0071360)2.50340123
96positive regulation of interleukin-2 production (GO:0032743)2.48251112
97positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.47496340
98JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.47325801
99positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.46564348
100regulation of mast cell activation (GO:0033003)2.45973227

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.52206138
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.75549361
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.68101158
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.64118493
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.26266013
6VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.81130673
7* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.75069385
8IRF8_27001747_Chip-Seq_BMDM_Mouse2.73231365
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.73124449
10MYC_22102868_ChIP-Seq_BL_Human2.52226043
11GATA1_22025678_ChIP-Seq_K562_Human2.42928050
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.36493953
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.34131380
14EZH2_22144423_ChIP-Seq_EOC_Human2.30319013
15RUNX_20019798_ChIP-Seq_JUKART_Human2.19014007
16SCL_19346495_ChIP-Seq_HPC-7_Human2.14101692
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.07589701
18DROSHA_22980978_ChIP-Seq_HELA_Human2.03466001
19MYB_26560356_Chip-Seq_TH2_Human1.92180159
20KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88827701
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87595316
22STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85497080
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.83493814
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.82483548
25SPI1_23127762_ChIP-Seq_K562_Human1.80729133
26MAF_26560356_Chip-Seq_TH1_Human1.80206944
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.76932967
28VDR_24763502_ChIP-Seq_THP-1_Human1.76686467
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76284671
30ESR1_20079471_ChIP-ChIP_T-47D_Human1.70640841
31GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.69640629
32VDR_24787735_ChIP-Seq_THP-1_Human1.66624118
33VDR_21846776_ChIP-Seq_THP-1_Human1.65897582
34MYB_26560356_Chip-Seq_TH1_Human1.60114969
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.58850087
36LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.57607140
37REST_21632747_ChIP-Seq_MESCs_Mouse1.57200940
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.53965516
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.53498491
40KDM2B_26808549_Chip-Seq_DND41_Human1.49543471
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.49504885
42TCF7_22412390_ChIP-Seq_EML_Mouse1.48507071
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48069192
44MAF_26560356_Chip-Seq_TH2_Human1.47638865
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44720625
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43483008
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41457299
48NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.41301837
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.40760277
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37273795
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.37186746
52SPI1_23547873_ChIP-Seq_NB4_Human1.37033392
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.34449569
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.33431734
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.29318995
56GATA3_27048872_Chip-Seq_THYMUS_Human1.27122497
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25026854
58BP1_19119308_ChIP-ChIP_Hs578T_Human1.23401384
59PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19997337
60GATA3_26560356_Chip-Seq_TH2_Human1.19567193
61UTX_26944678_Chip-Seq_JUKART_Human1.18028101
62REST_18959480_ChIP-ChIP_MESCs_Mouse1.17575781
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.16698946
64SMRT_27268052_Chip-Seq_Bcells_Human1.16629560
65VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15608377
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15594874
67ESR1_21235772_ChIP-Seq_MCF-7_Human1.14245319
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13725709
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13072607
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12137161
71SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11831427
72CIITA_25753668_ChIP-Seq_RAJI_Human1.08711052
73KDM2B_26808549_Chip-Seq_K562_Human1.06531905
74LXR_22292898_ChIP-Seq_THP-1_Human1.03494164
75PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03301583
76STAT1_20625510_ChIP-Seq_HELA_Human1.00809811
77CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00634045
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99586490
79PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99428564
80AR_21572438_ChIP-Seq_LNCaP_Human0.98841890
81OCT4_19829295_ChIP-Seq_ESCs_Human0.98748233
82BCOR_27268052_Chip-Seq_Bcells_Human0.98399222
83SMC4_20622854_ChIP-Seq_HELA_Human0.95195392
84CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94642149
85MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94554157
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94096468
87RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91983442
88PU_27001747_Chip-Seq_BMDM_Mouse0.91820932
89BCL6_27268052_Chip-Seq_Bcells_Human0.89723606
90PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88525037
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.88325123
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87959851
93P68_20966046_ChIP-Seq_HELA_Human0.86201089
94EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85961502
95KDM2B_26808549_Chip-Seq_JURKAT_Human0.85476328
96PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85033497
97RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.84432132
98GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84401697
99PRDM14_20953172_ChIP-Seq_ESCs_Human0.84051409
100SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.83513133

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.62666257
2MP0003303_peritoneal_inflammation3.02223217
3MP0005671_abnormal_response_to2.91729286
4MP0001790_abnormal_immune_system2.87916941
5MP0005387_immune_system_phenotype2.87916941
6MP0003724_increased_susceptibility_to2.81357751
7MP0001800_abnormal_humoral_immune2.74512352
8MP0005000_abnormal_immune_tolerance2.70339412
9MP0005310_abnormal_salivary_gland2.64375377
10MP0000685_abnormal_immune_system2.60086508
11MP0002148_abnormal_hypersensitivity_rea2.51957028
12MP0003436_decreased_susceptibility_to2.34743196
13MP0002723_abnormal_immune_serum2.33340074
14MP0009785_altered_susceptibility_to2.28294448
15MP0002452_abnormal_antigen_presenting2.24937208
16MP0004859_abnormal_synaptic_plasticity2.19774229
17MP0005025_abnormal_response_to2.05536158
18MP0002420_abnormal_adaptive_immunity2.05277249
19MP0003172_abnormal_lysosome_physiology2.05015118
20MP0001819_abnormal_immune_cell2.03160627
21MP0003183_abnormal_peptide_metabolism2.01453071
22MP0003763_abnormal_thymus_physiology2.01043103
23MP0002419_abnormal_innate_immunity1.92981125
24MP0001501_abnormal_sleep_pattern1.85689362
25MP0002064_seizures1.84298800
26MP0006082_CNS_inflammation1.80387241
27MP0001873_stomach_inflammation1.80230342
28MP0009745_abnormal_behavioral_response1.77006511
29MP0004381_abnormal_hair_follicle1.62732281
30MP0005075_abnormal_melanosome_morpholog1.62018367
31MP0003635_abnormal_synaptic_transmissio1.59752834
32MP0002398_abnormal_bone_marrow1.57328517
33MP0000716_abnormal_immune_system1.56971170
34MP0003787_abnormal_imprinting1.53648065
35MP0001968_abnormal_touch/_nociception1.49711638
36MP0003690_abnormal_glial_cell1.46345813
37MP0001845_abnormal_inflammatory_respons1.41386678
38MP0002063_abnormal_learning/memory/cond1.41196235
39MP0005646_abnormal_pituitary_gland1.41124645
40MP0004947_skin_inflammation1.40234663
41MP0010155_abnormal_intestine_physiology1.39174096
42MP0000015_abnormal_ear_pigmentation1.36407407
43MP0002405_respiratory_system_inflammati1.34310438
44MP0005423_abnormal_somatic_nervous1.31657103
45MP0002138_abnormal_hepatobiliary_system1.29469871
46MP0009333_abnormal_splenocyte_physiolog1.25287820
47MP0002272_abnormal_nervous_system1.24905286
48MP0000689_abnormal_spleen_morphology1.23602753
49MP0009046_muscle_twitch1.21864960
50MP0001348_abnormal_lacrimal_gland1.21577478
51MP0001533_abnormal_skeleton_physiology1.21014295
52MP0002166_altered_tumor_susceptibility1.20946136
53MP0003075_altered_response_to1.20431182
54MP0000920_abnormal_myelination1.16988649
55MP0003300_gastrointestinal_ulcer1.16716243
56MP0002429_abnormal_blood_cell1.13106089
57MP0002572_abnormal_emotion/affect_behav1.11374841
58MP0003045_fibrosis1.10903881
59MP0003880_abnormal_central_pattern1.08701694
60MP0003879_abnormal_hair_cell1.08418133
61MP0008874_decreased_physiological_sensi1.08307482
62MP0000604_amyloidosis1.07967661
63MP0009278_abnormal_bone_marrow1.07411374
64MP0002693_abnormal_pancreas_physiology1.07137017
65MP0002722_abnormal_immune_system1.04735007
66MP0005058_abnormal_lysosome_morphology1.04453887
67MP0008469_abnormal_protein_level1.02476880
68MP0004510_myositis1.01277120
69MP0000703_abnormal_thymus_morphology0.98901703
70MP0005379_endocrine/exocrine_gland_phen0.98692554
71MP0004270_analgesia0.97607731
72MP0001486_abnormal_startle_reflex0.96982469
73MP0008569_lethality_at_weaning0.96915782
74MP0000372_irregular_coat_pigmentation0.96906504
75MP0000569_abnormal_digit_pigmentation0.95568455
76MP0002254_reproductive_system_inflammat0.94521334
77MP0000371_diluted_coat_color0.94357652
78MP0005167_abnormal_blood-brain_barrier0.93379538
79MP0005535_abnormal_body_temperature0.91456796
80MP0002735_abnormal_chemical_nociception0.85464893
81MP0001986_abnormal_taste_sensitivity0.85464702
82MP0003329_amyloid_beta_deposits0.85462645
83MP0002006_tumorigenesis0.83577566
84MP0002736_abnormal_nociception_after0.82980411
85MP0004808_abnormal_hematopoietic_stem0.82869993
86MP0001970_abnormal_pain_threshold0.82616404
87MP0002009_preneoplasia0.82268914
88MP0005645_abnormal_hypothalamus_physiol0.78768620
89MP0008877_abnormal_DNA_methylation0.78503521
90MP0003866_abnormal_defecation0.77085477
91MP0003633_abnormal_nervous_system0.76992310
92MP0001919_abnormal_reproductive_system0.76904274
93MP0002733_abnormal_thermal_nociception0.74826793
94MP0002229_neurodegeneration0.74741982
95MP0003191_abnormal_cellular_cholesterol0.74047639
96MP0004043_abnormal_pH_regulation0.73625271
97MP0008057_abnormal_DNA_replication0.72842402
98MP0001440_abnormal_grooming_behavior0.72778356
99MP0005451_abnormal_body_composition0.70486347
100MP0002734_abnormal_mechanical_nocicepti0.70083886

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)4.20064147
2Optic neuritis (HP:0100653)4.20064147
3Recurrent bacterial skin infections (HP:0005406)3.81268235
4Orchitis (HP:0100796)3.76599536
5Abnormality of glycolipid metabolism (HP:0010969)3.68388693
6Abnormality of liposaccharide metabolism (HP:0010968)3.68388693
7Abnormality of glycosphingolipid metabolism (HP:0004343)3.68388693
8Myositis (HP:0100614)3.65942901
9Gastrointestinal stroma tumor (HP:0100723)3.64386411
10Recurrent cutaneous fungal infections (HP:0011370)3.42488231
11Chronic mucocutaneous candidiasis (HP:0002728)3.42488231
12Recurrent abscess formation (HP:0002722)3.38028026
13Agammaglobulinemia (HP:0004432)3.37721822
14Increased cerebral lipofuscin (HP:0011813)3.28965246
15Mediastinal lymphadenopathy (HP:0100721)3.28035910
16Papilledema (HP:0001085)3.27613849
17Vasculitis (HP:0002633)3.26222069
18Meningitis (HP:0001287)3.22036647
19Abnormality of macrophages (HP:0004311)3.18236784
20Recurrent fungal infections (HP:0002841)3.13838125
21Eczematoid dermatitis (HP:0000976)3.13800630
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.13254045
23Focal motor seizures (HP:0011153)3.11610459
24Increased neuronal autofluorescent lipopigment (HP:0002074)3.07369297
25Stomatitis (HP:0010280)3.02279660
26Pulmonary infiltrates (HP:0002113)2.96716702
27Recurrent viral infections (HP:0004429)2.92107285
28Atonic seizures (HP:0010819)2.89231218
29Mutism (HP:0002300)2.86497227
30Supranuclear gaze palsy (HP:0000605)2.86166001
31Recurrent skin infections (HP:0001581)2.85850175
32Encephalitis (HP:0002383)2.82071736
33Ocular albinism (HP:0001107)2.80837621
34Recurrent bronchitis (HP:0002837)2.76885636
35Febrile seizures (HP:0002373)2.70874704
36Panhypogammaglobulinemia (HP:0003139)2.68744387
37Loss of speech (HP:0002371)2.67678691
38Visual hallucinations (HP:0002367)2.60855306
39Elevated erythrocyte sedimentation rate (HP:0003565)2.59980822
40Progressive cerebellar ataxia (HP:0002073)2.59820015
41Diplopia (HP:0000651)2.58316851
42Abnormality of binocular vision (HP:0011514)2.58316851
43Dysostosis multiplex (HP:0000943)2.58063803
44Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.56371316
45Hemoptysis (HP:0002105)2.55111152
46Gastrointestinal infarctions (HP:0005244)2.54881208
47Keratoconjunctivitis sicca (HP:0001097)2.54072776
48Focal seizures (HP:0007359)2.52461185
49Keratoconjunctivitis (HP:0001096)2.51308365
50Neuronal loss in central nervous system (HP:0002529)2.33620813
51Colitis (HP:0002583)2.32641436
52Iris hypopigmentation (HP:0007730)2.30952032
53Abnormality of the prostate (HP:0008775)2.30372972
54Urinary bladder sphincter dysfunction (HP:0002839)2.23587165
55Slow saccadic eye movements (HP:0000514)2.23485339
56Neurofibrillary tangles (HP:0002185)2.22680895
57Epileptic encephalopathy (HP:0200134)2.22056445
58Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.20118128
59Chronic otitis media (HP:0000389)2.19706093
60Global brain atrophy (HP:0002283)2.19545691
61Apathy (HP:0000741)2.18704061
62Recurrent sinusitis (HP:0011108)2.17854318
63Absence seizures (HP:0002121)2.14040524
64Myokymia (HP:0002411)2.12802710
65Gastrointestinal inflammation (HP:0004386)2.12754905
66Urticaria (HP:0001025)2.11347604
67Dialeptic seizures (HP:0011146)2.10990628
68Memory impairment (HP:0002354)2.10532045
69T lymphocytopenia (HP:0005403)2.09764161
70Diminished motivation (HP:0000745)2.09711047
71Abnormality of T cell number (HP:0011839)2.09023014
72Cellulitis (HP:0100658)2.07706512
73Inflammation of the large intestine (HP:0002037)2.06457098
74IgG deficiency (HP:0004315)2.02607999
75Action tremor (HP:0002345)2.02552901
76Lymphopenia (HP:0001888)2.02075179
77Restrictive lung disease (HP:0002091)2.01531100
78Truncal ataxia (HP:0002078)2.01269648
79Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.00799085
80Obstructive lung disease (HP:0006536)2.00390855
81Chronic obstructive pulmonary disease (HP:0006510)2.00390855
82Hypokinesia (HP:0002375)1.99604569
83Ankle clonus (HP:0011448)1.97663941
84Osteomyelitis (HP:0002754)1.97065964
85Status epilepticus (HP:0002133)1.95593965
86Autoimmune hemolytic anemia (HP:0001890)1.95372527
87Prostate neoplasm (HP:0100787)1.94280192
88Pulmonary embolism (HP:0002204)1.93391931
89Autoimmune thrombocytopenia (HP:0001973)1.92676561
90Peripheral hypomyelination (HP:0007182)1.92493578
91Gaze-evoked nystagmus (HP:0000640)1.92391051
92Hemiplegia (HP:0002301)1.92104329
93Arterial thrombosis (HP:0004420)1.90852900
94Cerebral inclusion bodies (HP:0100314)1.88012260
95Premature loss of primary teeth (HP:0006323)1.87541269
96Abnormality of T cells (HP:0002843)1.86414303
97Gangrene (HP:0100758)1.84289096
98Abnormality of cells of the lymphoid lineage (HP:0012140)1.84101325
99Polyneuropathy (HP:0001271)1.83817159
100Abnormality of glycosaminoglycan metabolism (HP:0004371)1.83277808

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.39507228
2MAP4K13.13405466
3MAP3K132.92125779
4SIK22.73378829
5TAOK32.44334492
6IRAK42.42081346
7TNK22.37563376
8BLK2.34602395
9BMPR22.34501820
10PRPF4B2.28291617
11DAPK22.19339331
12TYK22.07776305
13MAP3K142.01856464
14JAK11.79869974
15ERN11.70681728
16MAP3K91.69249295
17SYK1.69213020
18CAMKK11.68828395
19TXK1.65768887
20IKBKE1.50931651
21NTRK31.32000324
22MAP2K61.31311925
23KIT1.29939365
24TBK11.29692746
25MATK1.28479470
26TAOK21.26983388
27IRAK31.25857985
28TRIB31.23332230
29FES1.18412533
30CAMK1D1.18363383
31PDK11.18345725
32IRAK11.13914542
33JAK21.13790666
34IKBKB1.13106519
35JAK31.11913923
36SIK31.10943874
37KSR21.09587142
38ZAP701.08158888
39IRAK21.05883998
40BTK1.05387807
41CSK1.00793324
42PAK61.00578308
43GRK60.98554289
44EPHA40.97877395
45MARK20.97390713
46LYN0.96884225
47PRKCH0.96791264
48HCK0.96545815
49MAPK120.95422948
50PDPK10.95293994
51CDC42BPA0.93431666
52CAMKK20.89719122
53CHUK0.83665974
54FRK0.81281763
55MARK30.80766115
56ADRBK20.80442682
57ARAF0.79705132
58MAP3K10.78751179
59EEF2K0.77506673
60LCK0.77361909
61TYRO30.76802193
62CSF1R0.74315243
63CDK120.73168376
64TAOK10.72230847
65HIPK20.71393446
66PRKD30.70688685
67TLK10.70051103
68ALK0.69491845
69TRPM70.68340290
70PRKCQ0.67622513
71STK110.66034818
72ITK0.65688246
73FGFR30.64524181
74MAPK110.64335880
75TEC0.62319578
76FGR0.61435086
77SIK10.61419229
78MAP3K110.60384079
79MAPKAPK30.58716845
80FGFR40.57167024
81NTRK20.54587124
82CDK50.54242586
83DAPK10.53662406
84NEK60.53226223
85OXSR10.51071124
86CAMK10.50977283
87MAP2K30.49205612
88MAPK130.48585407
89PRKCZ0.46328875
90ICK0.45973740
91GRK50.45971498
92CAMK1G0.45542102
93SGK30.43763809
94PINK10.41975678
95MAPK70.39646486
96CAMK40.39550246
97RIPK10.38403353
98MAPK40.37917612
99MAP3K70.35443547
100SGK20.34814098

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.06889365
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.98365318
3Autoimmune thyroid disease_Homo sapiens_hsa053202.64040262
4B cell receptor signaling pathway_Homo sapiens_hsa046622.62196047
5Graft-versus-host disease_Homo sapiens_hsa053322.59344718
6Type I diabetes mellitus_Homo sapiens_hsa049402.47746746
7Asthma_Homo sapiens_hsa053102.46351994
8Leishmaniasis_Homo sapiens_hsa051402.34905255
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.29441370
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.17469182
11Osteoclast differentiation_Homo sapiens_hsa043802.11594492
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.93627010
13Primary immunodeficiency_Homo sapiens_hsa053401.91131783
14Tuberculosis_Homo sapiens_hsa051521.82650474
15Staphylococcus aureus infection_Homo sapiens_hsa051501.77925256
16T cell receptor signaling pathway_Homo sapiens_hsa046601.62099899
17Rheumatoid arthritis_Homo sapiens_hsa053231.60719203
18Influenza A_Homo sapiens_hsa051641.60501925
19Synaptic vesicle cycle_Homo sapiens_hsa047211.51113553
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.50768504
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48295988
22Antigen processing and presentation_Homo sapiens_hsa046121.46680241
23Toxoplasmosis_Homo sapiens_hsa051451.45135409
24Nicotine addiction_Homo sapiens_hsa050331.44266943
25Measles_Homo sapiens_hsa051621.40478850
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39025518
27Long-term potentiation_Homo sapiens_hsa047201.29845814
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27481008
29Other glycan degradation_Homo sapiens_hsa005111.25566038
30Chemokine signaling pathway_Homo sapiens_hsa040621.25387119
31Morphine addiction_Homo sapiens_hsa050321.23365550
32TNF signaling pathway_Homo sapiens_hsa046681.20999470
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18551354
34African trypanosomiasis_Homo sapiens_hsa051431.13727016
35Herpes simplex infection_Homo sapiens_hsa051681.12653748
36Acute myeloid leukemia_Homo sapiens_hsa052211.08471709
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.07984073
38Viral myocarditis_Homo sapiens_hsa054161.04383065
39Lysosome_Homo sapiens_hsa041421.02935550
40VEGF signaling pathway_Homo sapiens_hsa043701.01636029
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98406548
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96203339
43Hepatitis C_Homo sapiens_hsa051600.95609379
44Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95014960
45Neurotrophin signaling pathway_Homo sapiens_hsa047220.94456281
46Prolactin signaling pathway_Homo sapiens_hsa049170.94373349
47Dorso-ventral axis formation_Homo sapiens_hsa043200.91852686
48Hepatitis B_Homo sapiens_hsa051610.90662594
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.89157711
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88840504
51Amphetamine addiction_Homo sapiens_hsa050310.87126362
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84480194
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83379434
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83177877
55GABAergic synapse_Homo sapiens_hsa047270.82165423
56Sphingolipid signaling pathway_Homo sapiens_hsa040710.81927877
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78371011
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77036607
59Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77016984
60GnRH signaling pathway_Homo sapiens_hsa049120.76989239
61Cholinergic synapse_Homo sapiens_hsa047250.76598351
62Hematopoietic cell lineage_Homo sapiens_hsa046400.76446135
63Phagosome_Homo sapiens_hsa041450.76373024
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76096749
65Circadian entrainment_Homo sapiens_hsa047130.74902820
66Insulin secretion_Homo sapiens_hsa049110.74198553
67Glutamatergic synapse_Homo sapiens_hsa047240.72475143
68ErbB signaling pathway_Homo sapiens_hsa040120.72352959
69Oxytocin signaling pathway_Homo sapiens_hsa049210.71560617
70mTOR signaling pathway_Homo sapiens_hsa041500.71199921
71Estrogen signaling pathway_Homo sapiens_hsa049150.70288603
72Non-small cell lung cancer_Homo sapiens_hsa052230.69940137
73Collecting duct acid secretion_Homo sapiens_hsa049660.69794659
74MAPK signaling pathway_Homo sapiens_hsa040100.69498826
75Epstein-Barr virus infection_Homo sapiens_hsa051690.66127625
76Inositol phosphate metabolism_Homo sapiens_hsa005620.65751641
77Salivary secretion_Homo sapiens_hsa049700.64532215
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63238275
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.61187595
80Legionellosis_Homo sapiens_hsa051340.60561647
81Type II diabetes mellitus_Homo sapiens_hsa049300.60154406
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.59846475
83Dopaminergic synapse_Homo sapiens_hsa047280.59164412
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59147448
85Cocaine addiction_Homo sapiens_hsa050300.58675595
86Calcium signaling pathway_Homo sapiens_hsa040200.57895502
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57887890
88Renal cell carcinoma_Homo sapiens_hsa052110.57491948
89Pertussis_Homo sapiens_hsa051330.54430924
90Gastric acid secretion_Homo sapiens_hsa049710.53490393
91ABC transporters_Homo sapiens_hsa020100.51474158
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48934608
93cAMP signaling pathway_Homo sapiens_hsa040240.47904546
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46425604
95Long-term depression_Homo sapiens_hsa047300.45553050
96Apoptosis_Homo sapiens_hsa042100.45219235
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44144872
98Ovarian steroidogenesis_Homo sapiens_hsa049130.42500831
99Glioma_Homo sapiens_hsa052140.42480898
100Malaria_Homo sapiens_hsa051440.41596236

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