ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.95960654
2	fucose catabolic process (GO:0019317)	4.41713078
3	L-fucose metabolic process (GO:0042354)	4.41713078
4	L-fucose catabolic process (GO:0042355)	4.41713078
5	DNA deamination (GO:0045006)	4.30215918
6	water-soluble vitamin biosynthetic process (GO:0042364)	4.17414051
7	protein complex biogenesis (GO:0070271)	3.92640965
8	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.78999757
9	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.78999757
10	NADH dehydrogenase complex assembly (GO:0010257)	3.78999757
11	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.74276660
12	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.69898026
13	mitochondrial respiratory chain complex assembly (GO:0033108)	3.69035559
14	respiratory chain complex IV assembly (GO:0008535)	3.59036502
15	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.59019261
16	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.57630828
17	ATP synthesis coupled proton transport (GO:0015986)	3.52338890
18	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.52338890
19	kynurenine metabolic process (GO:0070189)	3.43938832
20	platelet dense granule organization (GO:0060155)	3.42001027
21	protein-cofactor linkage (GO:0018065)	3.40865374
22	negative regulation of telomere maintenance (GO:0032205)	3.33648681
23	protein neddylation (GO:0045116)	3.30409252
24	maturation of 5.8S rRNA (GO:0000460)	3.30110267
25	cellular ketone body metabolic process (GO:0046950)	3.29390791
26	indole-containing compound catabolic process (GO:0042436)	3.29376317
27	indolalkylamine catabolic process (GO:0046218)	3.29376317
28	tryptophan catabolic process (GO:0006569)	3.29376317
29	indolalkylamine metabolic process (GO:0006586)	3.28153365
30	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.25448422
31	cytochrome complex assembly (GO:0017004)	3.24491307
32	detection of light stimulus involved in sensory perception (GO:0050962)	3.23701124
33	detection of light stimulus involved in visual perception (GO:0050908)	3.23701124
34	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.07746597
35	epithelial cilium movement (GO:0003351)	3.04801816
36	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.00133312
37	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.00133312
38	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.99804522
39	response to pheromone (GO:0019236)	2.98587206
40	ketone body metabolic process (GO:1902224)	2.97228615
41	regulation of cilium movement (GO:0003352)	2.95999486
42	pseudouridine synthesis (GO:0001522)	2.95015023
43	electron transport chain (GO:0022900)	2.93461139
44	piRNA metabolic process (GO:0034587)	2.93257195
45	intracellular protein transmembrane import (GO:0044743)	2.91074913
46	DNA double-strand break processing (GO:0000729)	2.90109005
47	respiratory electron transport chain (GO:0022904)	2.87699473
48	protein polyglutamylation (GO:0018095)	2.87567958
49	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.86613909
50	behavioral response to ethanol (GO:0048149)	2.86389998
51	nonmotile primary cilium assembly (GO:0035058)	2.81799113
52	tryptophan metabolic process (GO:0006568)	2.81443734
53	sulfation (GO:0051923)	2.81421299
54	preassembly of GPI anchor in ER membrane (GO:0016254)	2.78919739
55	replication fork processing (GO:0031297)	2.78849222
56	ubiquinone biosynthetic process (GO:0006744)	2.77499109
57	termination of RNA polymerase III transcription (GO:0006386)	2.75158221
58	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.75158221
59	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.72174826
60	kidney morphogenesis (GO:0060993)	2.70828517
61	recombinational repair (GO:0000725)	2.69361119
62	mannosylation (GO:0097502)	2.68120698
63	double-strand break repair via homologous recombination (GO:0000724)	2.67654201
64	negative regulation of mast cell activation (GO:0033004)	2.67263022
65	cilium morphogenesis (GO:0060271)	2.65520627
66	axoneme assembly (GO:0035082)	2.64965640
67	ubiquinone metabolic process (GO:0006743)	2.64408875
68	cytidine catabolic process (GO:0006216)	2.64004140
69	cytidine deamination (GO:0009972)	2.64004140
70	cytidine metabolic process (GO:0046087)	2.64004140
71	intraciliary transport (GO:0042073)	2.61709229
72	cellular biogenic amine catabolic process (GO:0042402)	2.61631108
73	amine catabolic process (GO:0009310)	2.61631108
74	rRNA catabolic process (GO:0016075)	2.61518971
75	proteasome assembly (GO:0043248)	2.59625131
76	base-excision repair, AP site formation (GO:0006285)	2.58333507
77	photoreceptor cell development (GO:0042461)	2.58149685
78	reciprocal meiotic recombination (GO:0007131)	2.57739866
79	reciprocal DNA recombination (GO:0035825)	2.57739866
80	tRNA processing (GO:0008033)	2.56576865
81	synapsis (GO:0007129)	2.55697433
82	rhodopsin mediated signaling pathway (GO:0016056)	2.55261671
83	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.54813488
84	dopamine transport (GO:0015872)	2.54581239
85	signal peptide processing (GO:0006465)	2.54228102
86	cilium organization (GO:0044782)	2.52715849
87	protein K6-linked ubiquitination (GO:0085020)	2.51598572
88	prenylation (GO:0097354)	2.51200896
89	protein prenylation (GO:0018342)	2.51200896
90	protein localization to cilium (GO:0061512)	2.50754011
91	chaperone-mediated protein transport (GO:0072321)	2.49343225
92	neural tube formation (GO:0001841)	2.47115503
93	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.46605059
94	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.46258699
95	regulation of glucokinase activity (GO:0033131)	2.46074149
96	regulation of hexokinase activity (GO:1903299)	2.46074149
97	retinal cone cell development (GO:0046549)	2.45503139
98	male meiosis I (GO:0007141)	2.45421901
99	regulation of mesoderm development (GO:2000380)	2.44609095
100	cilium assembly (GO:0042384)	2.43967164

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.07000795
2	VDR_22108803_ChIP-Seq_LS180_Human	3.44212533
3	* GABP_17652178_ChIP-ChIP_JURKAT_Human	2.73723473
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.72265052
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.69813724
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.57588845
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.54510418
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.44652149
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.38764933
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.36653887
11	EWS_26573619_Chip-Seq_HEK293_Human	2.25900466
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.25792808
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.24508368
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.22850791
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.20762436
16	FUS_26573619_Chip-Seq_HEK293_Human	2.16583111
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.07774032
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.99423680
19	P300_19829295_ChIP-Seq_ESCs_Human	1.98059660
20	* CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.93633762
21	ELK1_19687146_ChIP-ChIP_HELA_Human	1.91594156
22	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.89911246
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.83245355
24	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.83165085
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.80670102
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.79967983
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.76277102
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.75720141
29	MYC_18940864_ChIP-ChIP_HL60_Human	1.74074738
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.71444799
31	VDR_23849224_ChIP-Seq_CD4+_Human	1.67981731
32	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.67196237
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.65408280
34	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.64004277
35	TP53_22573176_ChIP-Seq_HFKS_Human	1.59648615
36	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.55432418
37	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.45771626
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.44058987
39	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.43753613
40	BCAT_22108803_ChIP-Seq_LS180_Human	1.43029072
41	* NANOG_19829295_ChIP-Seq_ESCs_Human	1.40475652
42	* SOX2_19829295_ChIP-Seq_ESCs_Human	1.40475652
43	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.38314528
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.37756075
45	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.37756075
46	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.37078985
47	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.36192758
48	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.35818609
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.31139763
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.31139763
51	STAT3_23295773_ChIP-Seq_U87_Human	1.30504839
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.28942049
53	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.28791268
54	AR_25329375_ChIP-Seq_VCAP_Human	1.27007356
55	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.26710870
56	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.25837323
57	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.24771032
58	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.24209665
59	AR_20517297_ChIP-Seq_VCAP_Human	1.23303339
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.23178043
61	SMAD4_21799915_ChIP-Seq_A2780_Human	1.22631520
62	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.21436053
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21316903
64	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.20881718
65	TCF4_23295773_ChIP-Seq_U87_Human	1.18902794
66	RNF2_27304074_Chip-Seq_NSC_Mouse	1.18622829
67	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.18108217
68	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.18030040
69	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.17736764
70	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15547652
71	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.14572285
72	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.14320851
73	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.14071082
74	FOXP3_21729870_ChIP-Seq_TREG_Human	1.13942105
75	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.12178611
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11464661
77	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11123096
78	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.11123096
79	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10807946
80	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.09540831
81	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09492733
82	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.07825431
83	NCOR_22424771_ChIP-Seq_293T_Human	1.07514619
84	HOXB7_26014856_ChIP-Seq_BT474_Human	1.07093888
85	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.06501023
86	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.06382499
87	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.05695418
88	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.04622018
89	RUNX2_22187159_ChIP-Seq_PCA_Human	1.02209321
90	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.01683525
91	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.00966846
92	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00542621
93	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.00423068
94	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.99642697
95	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99492357
96	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.98062408
97	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.96622999
98	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.96463540
99	P53_22387025_ChIP-Seq_ESCs_Mouse	0.96103268
100	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.95443045

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	2.90556948
2	MP0006292_abnormal_olfactory_placode	2.62313214
3	MP0003136_yellow_coat_color	2.59492860
4	MP0002102_abnormal_ear_morphology	2.54895269
5	MP0008877_abnormal_DNA_methylation	2.52444722
6	MP0003646_muscle_fatigue	2.51111979
7	MP0005551_abnormal_eye_electrophysiolog	2.48603590
8	MP0002837_dystrophic_cardiac_calcinosis	2.48280239
9	MP0004147_increased_porphyrin_level	2.26468317
10	MP0001986_abnormal_taste_sensitivity	2.12939001
11	MP0006072_abnormal_retinal_apoptosis	2.09980647
12	MP0004142_abnormal_muscle_tone	2.06940271
13	MP0002938_white_spotting	2.03885497
14	MP0000569_abnormal_digit_pigmentation	2.00716738
15	MP0003011_delayed_dark_adaptation	1.99113236
16	MP0005084_abnormal_gallbladder_morpholo	1.93847264
17	MP0001529_abnormal_vocalization	1.87641641
18	MP0005253_abnormal_eye_physiology	1.78476603
19	MP0000372_irregular_coat_pigmentation	1.77377481
20	MP0001485_abnormal_pinna_reflex	1.76461387
21	MP0001968_abnormal_touch/_nociception	1.76130835
22	MP0008875_abnormal_xenobiotic_pharmacok	1.74700531
23	MP0008872_abnormal_physiological_respon	1.74005134
24	MP0002638_abnormal_pupillary_reflex	1.73313037
25	MP0005645_abnormal_hypothalamus_physiol	1.72020197
26	MP0002876_abnormal_thyroid_physiology	1.68823745
27	MP0009379_abnormal_foot_pigmentation	1.68162271
28	MP0002736_abnormal_nociception_after	1.67894961
29	MP0009046_muscle_twitch	1.64750023
30	MP0004885_abnormal_endolymph	1.60252584
31	MP0005174_abnormal_tail_pigmentation	1.59994610
32	MP0006276_abnormal_autonomic_nervous	1.59112988
33	MP0003718_maternal_effect	1.56522667
34	MP0008058_abnormal_DNA_repair	1.51471937
35	MP0003880_abnormal_central_pattern	1.49666535
36	MP0009745_abnormal_behavioral_response	1.49215703
37	MP0003890_abnormal_embryonic-extraembry	1.48265352
38	MP0000427_abnormal_hair_cycle	1.45877143
39	MP0002160_abnormal_reproductive_system	1.45535950
40	MP0004145_abnormal_muscle_electrophysio	1.44715836
41	MP0005646_abnormal_pituitary_gland	1.41885729
42	MP0002272_abnormal_nervous_system	1.39008738
43	MP0005389_reproductive_system_phenotype	1.37498134
44	MP0004133_heterotaxia	1.37364954
45	MP0002163_abnormal_gland_morphology	1.35508958
46	MP0002653_abnormal_ependyma_morphology	1.34920703
47	MP0002095_abnormal_skin_pigmentation	1.32304211
48	MP0001486_abnormal_startle_reflex	1.29635991
49	MP0001293_anophthalmia	1.29224221
50	MP0001984_abnormal_olfaction	1.27510979
51	MP0004043_abnormal_pH_regulation	1.25953876
52	MP0000631_abnormal_neuroendocrine_gland	1.22332448
53	MP0002277_abnormal_respiratory_mucosa	1.21142925
54	MP0002234_abnormal_pharynx_morphology	1.18910971
55	MP0004215_abnormal_myocardial_fiber	1.18246038
56	MP0001501_abnormal_sleep_pattern	1.16066107
57	MP0005195_abnormal_posterior_eye	1.14840459
58	MP0002928_abnormal_bile_duct	1.14636249
59	MP0004742_abnormal_vestibular_system	1.14342475
60	MP0001919_abnormal_reproductive_system	1.09590006
61	MP0005410_abnormal_fertilization	1.09150651
62	MP0002735_abnormal_chemical_nociception	1.08941845
63	MP0002557_abnormal_social/conspecific_i	1.05646164
64	MP0008789_abnormal_olfactory_epithelium	1.04386545
65	MP0005377_hearing/vestibular/ear_phenot	1.03007329
66	MP0003878_abnormal_ear_physiology	1.03007329
67	MP0005379_endocrine/exocrine_gland_phen	1.01301107
68	MP0005075_abnormal_melanosome_morpholog	1.00658756
69	MP0005171_absent_coat_pigmentation	1.00197148
70	MP0001324_abnormal_eye_pigmentation	0.99070312
71	MP0003137_abnormal_impulse_conducting	0.97969293
72	MP0005085_abnormal_gallbladder_physiolo	0.97683057
73	MP0001905_abnormal_dopamine_level	0.96453315
74	MP0002751_abnormal_autonomic_nervous	0.96225939
75	MP0002733_abnormal_thermal_nociception	0.95731154
76	MP0004924_abnormal_behavior	0.95458374
77	MP0005386_behavior/neurological_phenoty	0.95458374
78	MP0002067_abnormal_sensory_capabilities	0.95320067
79	MP0001970_abnormal_pain_threshold	0.93300091
80	MP0000383_abnormal_hair_follicle	0.93038343
81	MP0002752_abnormal_somatic_nervous	0.90303227
82	MP0002210_abnormal_sex_determination	0.89949197
83	MP0003567_abnormal_fetal_cardiomyocyte	0.88514211
84	MP0003186_abnormal_redox_activity	0.88132727
85	MP0002572_abnormal_emotion/affect_behav	0.87406899
86	MP0002138_abnormal_hepatobiliary_system	0.86983964
87	MP0000647_abnormal_sebaceous_gland	0.86808205
88	MP0008775_abnormal_heart_ventricle	0.86762348
89	MP0002254_reproductive_system_inflammat	0.85556289
90	MP0008995_early_reproductive_senescence	0.83916188
91	MP0003698_abnormal_male_reproductive	0.82801989
92	MP0001929_abnormal_gametogenesis	0.82257465
93	MP0005423_abnormal_somatic_nervous	0.82211023
94	MP0003950_abnormal_plasma_membrane	0.82064593
95	MP0003119_abnormal_digestive_system	0.81749978
96	MP0002064_seizures	0.81452482
97	MP0001764_abnormal_homeostasis	0.80327290
98	MP0003937_abnormal_limbs/digits/tail_de	0.79948704
99	MP0003787_abnormal_imprinting	0.79934922
100	MP0000026_abnormal_inner_ear	0.79461870

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.38015523
2	Abnormality of midbrain morphology (HP:0002418)	4.14374677
3	Molar tooth sign on MRI (HP:0002419)	4.14374677
4	Pancreatic fibrosis (HP:0100732)	3.91510412
5	True hermaphroditism (HP:0010459)	3.76445169
6	Congenital stationary night blindness (HP:0007642)	3.65589022
7	Nephronophthisis (HP:0000090)	3.42823965
8	Type II lissencephaly (HP:0007260)	3.40275765
9	Acute necrotizing encephalopathy (HP:0006965)	3.20840814
10	Medial flaring of the eyebrow (HP:0010747)	3.04204524
11	Mitochondrial inheritance (HP:0001427)	2.98541458
12	Abnormality of the renal medulla (HP:0100957)	2.97550416
13	Abnormality of the renal cortex (HP:0011035)	2.93675964
14	Increased CSF lactate (HP:0002490)	2.89461672
15	Acute encephalopathy (HP:0006846)	2.85098542
16	Abolished electroretinogram (ERG) (HP:0000550)	2.84976708
17	Congenital, generalized hypertrichosis (HP:0004540)	2.79216082
18	Birth length less than 3rd percentile (HP:0003561)	2.74213442
19	Abnormal mitochondria in muscle tissue (HP:0008316)	2.73745800
20	Progressive macrocephaly (HP:0004481)	2.73198509
21	Lipid accumulation in hepatocytes (HP:0006561)	2.67460473
22	Attenuation of retinal blood vessels (HP:0007843)	2.66753126
23	Increased hepatocellular lipid droplets (HP:0006565)	2.65057050
24	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.62094437
25	Abnormality of alanine metabolism (HP:0010916)	2.62094437
26	Hyperalaninemia (HP:0003348)	2.62094437
27	Inability to walk (HP:0002540)	2.58974819
28	Sclerocornea (HP:0000647)	2.49170099
29	Hyperventilation (HP:0002883)	2.47213082
30	3-Methylglutaconic aciduria (HP:0003535)	2.45878210
31	Pendular nystagmus (HP:0012043)	2.45342821
32	Gait imbalance (HP:0002141)	2.43616122
33	Hepatocellular necrosis (HP:0001404)	2.42208956
34	Cystic liver disease (HP:0006706)	2.41937115
35	Renal cortical cysts (HP:0000803)	2.41749868
36	Abnormality of the pons (HP:0007361)	2.41550915
37	Abnormal rod and cone electroretinograms (HP:0008323)	2.39525550
38	Congenital primary aphakia (HP:0007707)	2.39042111
39	Methylmalonic acidemia (HP:0002912)	2.38167346
40	Cerebellar dysplasia (HP:0007033)	2.33255613
41	Tubular atrophy (HP:0000092)	2.32383549
42	Hypoplasia of the pons (HP:0012110)	2.31440163
43	Hepatic necrosis (HP:0002605)	2.30307734
44	Progressive inability to walk (HP:0002505)	2.28836375
45	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.28621655
46	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.24106437
47	Abnormal drinking behavior (HP:0030082)	2.23014848
48	Polydipsia (HP:0001959)	2.23014848
49	Chronic hepatic failure (HP:0100626)	2.21683504
50	Nephrogenic diabetes insipidus (HP:0009806)	2.21028935
51	Large for gestational age (HP:0001520)	2.19245701
52	Optic disc pallor (HP:0000543)	2.17337093
53	Abnormal number of erythroid precursors (HP:0012131)	2.16276008
54	Concave nail (HP:0001598)	2.15856535
55	Abnormal biliary tract physiology (HP:0012439)	2.15317296
56	Bile duct proliferation (HP:0001408)	2.15317296
57	Furrowed tongue (HP:0000221)	2.14832492
58	Colon cancer (HP:0003003)	2.13564134
59	Anencephaly (HP:0002323)	2.10783742
60	Lissencephaly (HP:0001339)	2.09579084
61	Male pseudohermaphroditism (HP:0000037)	2.08955967
62	Renal Fanconi syndrome (HP:0001994)	2.08753750
63	Congenital hepatic fibrosis (HP:0002612)	2.07381706
64	Methylmalonic aciduria (HP:0012120)	2.04102691
65	Increased serum lactate (HP:0002151)	2.02186546
66	Bony spicule pigmentary retinopathy (HP:0007737)	2.00702330
67	Chorioretinal atrophy (HP:0000533)	1.99609430
68	Decreased central vision (HP:0007663)	1.97977309
69	Genital tract atresia (HP:0001827)	1.97750703
70	Hypothermia (HP:0002045)	1.96569625
71	Retinal dysplasia (HP:0007973)	1.94748664
72	Abnormality of cells of the erythroid lineage (HP:0012130)	1.93864136
73	Vaginal atresia (HP:0000148)	1.92095961
74	Abnormal respiratory epithelium morphology (HP:0012253)	1.88944103
75	Abnormal respiratory motile cilium morphology (HP:0005938)	1.88944103
76	Cerebral edema (HP:0002181)	1.87593920
77	Short tibia (HP:0005736)	1.87032516
78	Absent/shortened dynein arms (HP:0200106)	1.85853107
79	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.85853107
80	Postaxial foot polydactyly (HP:0001830)	1.85683676
81	Increased corneal curvature (HP:0100692)	1.85190109
82	Keratoconus (HP:0000563)	1.85190109
83	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.84990159
84	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.84067320
85	Patellar aplasia (HP:0006443)	1.83576783
86	Optic nerve hypoplasia (HP:0000609)	1.83305586
87	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.80481466
88	Aplasia/Hypoplasia of the patella (HP:0006498)	1.79496665
89	Lactic acidosis (HP:0003128)	1.78495191
90	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.77025634
91	Polyuria (HP:0000103)	1.76661811
92	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.73668035
93	Aplasia/hypoplasia of the uterus (HP:0008684)	1.72227156
94	Abnormality of renal resorption (HP:0011038)	1.72179160
95	Broad-based gait (HP:0002136)	1.70522191
96	Poor coordination (HP:0002370)	1.70167125
97	Supernumerary spleens (HP:0009799)	1.69828062
98	Gaze-evoked nystagmus (HP:0000640)	1.69709776
99	Exertional dyspnea (HP:0002875)	1.69062114
100	Postaxial hand polydactyly (HP:0001162)	1.68991972

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.11767430
2	BMPR1B	3.48118725
3	ADRBK2	3.09649672
4	ZAK	3.04476922
5	ACVR1B	2.91024573
6	NUAK1	2.56547988
7	WNK3	2.44931521
8	INSRR	2.42573744
9	WNK4	2.39177276
10	MAP4K2	2.37876923
11	TLK1	2.33780991
12	GRK1	2.18873652
13	TAOK3	2.09604868
14	STK16	1.74688907
15	MKNK2	1.60017473
16	TXK	1.60014807
17	VRK2	1.55683065
18	MAPK13	1.54087317
19	STK39	1.52518410
20	OXSR1	1.47442571
21	PINK1	1.44424594
22	DAPK2	1.37168629
23	TIE1	1.36637334
24	CASK	1.34367436
25	VRK1	1.34125562
26	TGFBR1	1.33414827
27	MST4	1.29298706
28	PNCK	1.23209547
29	STK38L	1.16736610
30	ADRBK1	1.16392576
31	MKNK1	1.14050251
32	EIF2AK3	1.12321549
33	WEE1	1.11101102
34	TNIK	1.10709792
35	BCKDK	1.10254508
36	DYRK2	1.09571403
37	BRSK2	1.09541459
38	CAMKK2	1.05374025
39	MAP3K4	1.04446125
40	TRIM28	0.98126052
41	PLK3	0.93779119
42	TSSK6	0.93513633
43	PLK2	0.93487421
44	PLK4	0.92115680
45	MAP3K12	0.91973295
46	PAK3	0.91631678
47	BUB1	0.88871516
48	PRKCG	0.85485786
49	STK3	0.84205875
50	PHKG1	0.81771084
51	PHKG2	0.81771084
52	PASK	0.81564699
53	NEK1	0.80856610
54	PRKCE	0.79133429
55	TEC	0.78959108
56	CSNK1G1	0.77682114
57	CDC7	0.75884946
58	NME1	0.72568339
59	CSNK1G2	0.70172365
60	CSNK1G3	0.69881481
61	IKBKB	0.69236917
62	OBSCN	0.68475028
63	PIK3CA	0.67008143
64	MAP2K7	0.61765991
65	MARK1	0.60644453
66	MUSK	0.60040868
67	CSNK1A1L	0.59750636
68	TAF1	0.59473040
69	PRKCQ	0.59351020
70	CHEK2	0.57783478
71	SRPK1	0.56916856
72	RPS6KA5	0.56645872
73	MAPK15	0.55784727
74	MAPKAPK5	0.54419480
75	PLK1	0.52057379
76	EIF2AK2	0.51485897
77	ITK	0.49875784
78	GRK7	0.48100519
79	BCR	0.48099674
80	MAP2K6	0.46096009
81	CSNK1A1	0.44309050
82	CAMK2A	0.43598071
83	PTK2B	0.43547568
84	KIT	0.42311352
85	ATR	0.42245617
86	NEK2	0.41961299
87	PRKACA	0.41712737
88	PRKCI	0.39942726
89	MAP3K13	0.39594365
90	MAPKAPK3	0.37387108
91	CDK19	0.37209943
92	CHUK	0.36650179
93	PKN1	0.34079816
94	ERBB3	0.34024943
95	IRAK1	0.33958390
96	EIF2AK1	0.30922462
97	PRKCA	0.30322670
98	CSNK2A1	0.29355964
99	CAMK1	0.27399888
100	PIK3CG	0.26732162

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.27053335
2	Parkinsons disease_Homo sapiens_hsa05012	2.59999025
3	Phototransduction_Homo sapiens_hsa04744	2.49775289
4	Protein export_Homo sapiens_hsa03060	2.47706826
5	RNA polymerase_Homo sapiens_hsa03020	2.35813353
6	Ribosome_Homo sapiens_hsa03010	2.31366473
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.28938262
8	Homologous recombination_Homo sapiens_hsa03440	2.25280812
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.16481477
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.14028443
11	Nitrogen metabolism_Homo sapiens_hsa00910	2.09545616
12	Linoleic acid metabolism_Homo sapiens_hsa00591	2.08508307
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.96894826
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.96438682
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.90368720
16	Basal transcription factors_Homo sapiens_hsa03022	1.89976020
17	Butanoate metabolism_Homo sapiens_hsa00650	1.89674787
18	Proteasome_Homo sapiens_hsa03050	1.89261217
19	Huntingtons disease_Homo sapiens_hsa05016	1.80686942
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.76246055
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.73929259
22	Alzheimers disease_Homo sapiens_hsa05010	1.66437157
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.59700609
24	RNA degradation_Homo sapiens_hsa03018	1.55595750
25	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.53699836
26	One carbon pool by folate_Homo sapiens_hsa00670	1.53156227
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.51295361
28	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.49127165
29	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.47638726
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.46890309
31	Nicotine addiction_Homo sapiens_hsa05033	1.45105656
32	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.40404111
33	Caffeine metabolism_Homo sapiens_hsa00232	1.37905322
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.36006515
35	Propanoate metabolism_Homo sapiens_hsa00640	1.33195908
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.30472554
37	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.19996428
38	Peroxisome_Homo sapiens_hsa04146	1.19657046
39	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.18518578
40	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.12371796
41	Regulation of autophagy_Homo sapiens_hsa04140	1.07313065
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.06585084
43	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.02015654
44	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.00962919
45	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00330437
46	Nucleotide excision repair_Homo sapiens_hsa03420	0.99547350
47	Purine metabolism_Homo sapiens_hsa00230	0.98048303
48	Olfactory transduction_Homo sapiens_hsa04740	0.96725169
49	Pyrimidine metabolism_Homo sapiens_hsa00240	0.94664547
50	Taste transduction_Homo sapiens_hsa04742	0.94540113
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93706674
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.91943931
53	Steroid biosynthesis_Homo sapiens_hsa00100	0.91125884
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.90778719
55	ABC transporters_Homo sapiens_hsa02010	0.87805259
56	RNA transport_Homo sapiens_hsa03013	0.85872426
57	Retinol metabolism_Homo sapiens_hsa00830	0.83193734
58	Morphine addiction_Homo sapiens_hsa05032	0.79048098
59	Mismatch repair_Homo sapiens_hsa03430	0.78982088
60	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.78264710
61	Sulfur metabolism_Homo sapiens_hsa00920	0.78206513
62	Collecting duct acid secretion_Homo sapiens_hsa04966	0.76495667
63	Metabolic pathways_Homo sapiens_hsa01100	0.74763578
64	Sulfur relay system_Homo sapiens_hsa04122	0.73407274
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73039353
66	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.70710388
67	Primary immunodeficiency_Homo sapiens_hsa05340	0.70149570
68	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.68014584
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.67451852
70	Serotonergic synapse_Homo sapiens_hsa04726	0.67328050
71	Non-homologous end-joining_Homo sapiens_hsa03450	0.65478616
72	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.65255422
73	Mineral absorption_Homo sapiens_hsa04978	0.64053669
74	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.62539281
75	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.61198703
76	Histidine metabolism_Homo sapiens_hsa00340	0.61175253
77	Insulin secretion_Homo sapiens_hsa04911	0.60886898
78	GABAergic synapse_Homo sapiens_hsa04727	0.59537642
79	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.59082020
80	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.58778010
81	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.58585844
82	Fat digestion and absorption_Homo sapiens_hsa04975	0.58407981
83	Glycerolipid metabolism_Homo sapiens_hsa00561	0.55516908
84	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.52679101
85	Asthma_Homo sapiens_hsa05310	0.52469997
86	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.51421066
87	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.51164170
88	Fatty acid degradation_Homo sapiens_hsa00071	0.47601113
89	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.46766020
90	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.45345963
91	Base excision repair_Homo sapiens_hsa03410	0.44797870
92	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.44025599
93	Spliceosome_Homo sapiens_hsa03040	0.41769882
94	Circadian entrainment_Homo sapiens_hsa04713	0.40981810
95	Glutamatergic synapse_Homo sapiens_hsa04724	0.40030762
96	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.38467519
97	Fatty acid elongation_Homo sapiens_hsa00062	0.37330093
98	Glutathione metabolism_Homo sapiens_hsa00480	0.34741207
99	Circadian rhythm_Homo sapiens_hsa04710	0.32366761
100	Arginine and proline metabolism_Homo sapiens_hsa00330	0.32060576

C9orf85

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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