CA10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the carbonic anhydrase family of zinc metalloenzymes, which catalyze the reversible hydration of carbon dioxide in various biological processes. The protein encoded by this gene is an acatalytic member of the alpha-carbonic anhydrase subgroup, and it is thought to play a role in the central nervous system, especially in brain development. Multiple transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)8.13112894
2synaptic vesicle docking involved in exocytosis (GO:0016081)7.68179273
3regulation of short-term neuronal synaptic plasticity (GO:0048172)7.25055420
4glutamate secretion (GO:0014047)7.05217140
5synaptic vesicle exocytosis (GO:0016079)6.65944761
6regulation of synaptic vesicle exocytosis (GO:2000300)6.10655112
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.82322753
8membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.55532521
9ionotropic glutamate receptor signaling pathway (GO:0035235)5.49788257
10neurotransmitter secretion (GO:0007269)5.41173433
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.39327478
12cellular potassium ion homeostasis (GO:0030007)5.35633395
13regulation of synaptic vesicle transport (GO:1902803)5.28661033
14locomotory exploration behavior (GO:0035641)5.22341548
15vocalization behavior (GO:0071625)5.07951734
16sodium ion export (GO:0071436)4.95394763
17regulation of neuronal synaptic plasticity (GO:0048168)4.87560373
18postsynaptic membrane organization (GO:0001941)4.77768886
19exploration behavior (GO:0035640)4.70628661
20neuron cell-cell adhesion (GO:0007158)4.67187318
21synaptic transmission, glutamatergic (GO:0035249)4.66920837
22cerebellar granule cell differentiation (GO:0021707)4.66085517
23neurotransmitter-gated ion channel clustering (GO:0072578)4.65083599
24neuronal action potential propagation (GO:0019227)4.63563805
25regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.56205263
26positive regulation of synapse maturation (GO:0090129)4.49848030
27regulation of long-term neuronal synaptic plasticity (GO:0048169)4.45288144
28glutamate receptor signaling pathway (GO:0007215)4.43589165
29L-amino acid import (GO:0043092)4.42257278
30protein localization to synapse (GO:0035418)4.36234156
31neurotransmitter transport (GO:0006836)4.33686817
32regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.30977406
33neuron-neuron synaptic transmission (GO:0007270)4.29794639
34negative regulation of synaptic transmission, GABAergic (GO:0032229)4.28945850
35dendritic spine morphogenesis (GO:0060997)4.27900409
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.24126016
37regulation of glutamate receptor signaling pathway (GO:1900449)4.13686292
38layer formation in cerebral cortex (GO:0021819)4.10623970
39cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.09175439
40regulation of excitatory postsynaptic membrane potential (GO:0060079)4.02142533
41presynaptic membrane organization (GO:0097090)3.99982937
42amino acid import (GO:0043090)3.99191857
43positive regulation of membrane potential (GO:0045838)3.98624052
44potassium ion homeostasis (GO:0055075)3.95103969
45regulation of neurotransmitter levels (GO:0001505)3.93775298
46regulation of synapse structural plasticity (GO:0051823)3.91251547
47gamma-aminobutyric acid transport (GO:0015812)3.88678778
48regulation of neurotransmitter secretion (GO:0046928)3.87448864
49auditory behavior (GO:0031223)3.86872862
50synaptic vesicle endocytosis (GO:0048488)3.86392593
51positive regulation of dendritic spine development (GO:0060999)3.84170901
52neuronal ion channel clustering (GO:0045161)3.82292174
53presynaptic membrane assembly (GO:0097105)3.81963228
54gamma-aminobutyric acid signaling pathway (GO:0007214)3.80025459
55long-term memory (GO:0007616)3.79269589
56regulation of postsynaptic membrane potential (GO:0060078)3.77613889
57neuromuscular process controlling balance (GO:0050885)3.77221980
58regulation of vesicle fusion (GO:0031338)3.75218239
59membrane depolarization during action potential (GO:0086010)3.72506867
60regulation of synaptic plasticity (GO:0048167)3.72360408
61regulation of synapse maturation (GO:0090128)3.68650367
62potassium ion import (GO:0010107)3.66310145
63axon ensheathment in central nervous system (GO:0032291)3.64009999
64central nervous system myelination (GO:0022010)3.64009999
65positive regulation of dendritic spine morphogenesis (GO:0061003)3.62549413
66regulation of dendritic spine morphogenesis (GO:0061001)3.62265504
67positive regulation of neurotransmitter secretion (GO:0001956)3.61069275
68neuron recognition (GO:0008038)3.58732763
69cell communication by electrical coupling (GO:0010644)3.55755353
70positive regulation of neurotransmitter transport (GO:0051590)3.52430708
71negative regulation of dendrite morphogenesis (GO:0050774)3.51235030
72membrane depolarization (GO:0051899)3.50720128
73regulation of neurotransmitter transport (GO:0051588)3.50439479
74transmission of nerve impulse (GO:0019226)3.50419743
75cellular sodium ion homeostasis (GO:0006883)3.49999806
76regulation of voltage-gated calcium channel activity (GO:1901385)3.49488084
77cerebellar Purkinje cell differentiation (GO:0021702)3.45497118
78response to auditory stimulus (GO:0010996)3.42331924
79regulation of ARF protein signal transduction (GO:0032012)3.37603170
80proline transport (GO:0015824)3.37212840
81regulation of dendritic spine development (GO:0060998)3.34889637
82regulation of synaptic transmission, glutamatergic (GO:0051966)3.33788108
83cell migration in hindbrain (GO:0021535)3.33347063
84negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.30769718
85G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.29216477
86regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.26756015
87neurotransmitter uptake (GO:0001504)3.25846709
88establishment of mitochondrion localization (GO:0051654)3.24016582
89synaptic transmission (GO:0007268)3.21056507
90positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.20863319
91regulation of synaptic transmission (GO:0050804)3.17407241
92neuromuscular process (GO:0050905)3.17249825
93axonal fasciculation (GO:0007413)3.17223776
94neuromuscular process controlling posture (GO:0050884)3.16374385
95establishment of synaptic vesicle localization (GO:0097480)3.14691313
96synaptic vesicle transport (GO:0048489)3.14691313
97mechanosensory behavior (GO:0007638)3.11224868
98adult walking behavior (GO:0007628)3.09059478
99G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.08567686
100long-term synaptic potentiation (GO:0060291)3.07902622

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.83529860
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.98286508
3REST_21632747_ChIP-Seq_MESCs_Mouse3.29490219
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.20089286
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09883245
6GBX2_23144817_ChIP-Seq_PC3_Human2.99973076
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98399494
8* DROSHA_22980978_ChIP-Seq_HELA_Human2.88082408
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.80050333
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.71689496
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.65613410
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.65030464
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64986931
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64986931
15REST_18959480_ChIP-ChIP_MESCs_Mouse2.62229911
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57933289
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.54208931
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52137432
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46800945
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45067149
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.44178973
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.42509401
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.36850512
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.33919261
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.31068871
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.19398352
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.98326776
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.96321136
29RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.79103243
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75530430
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73429841
32RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.72686256
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58853096
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58659388
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54751337
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54740434
37RING1B_27294783_Chip-Seq_ESCs_Mouse1.51593431
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.50557165
39RNF2_27304074_Chip-Seq_NSC_Mouse1.46441237
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45210616
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.42672755
42NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38119534
43* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.35370925
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34829358
45* AR_21572438_ChIP-Seq_LNCaP_Human1.32417556
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27060040
47ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24555256
48* SMAD4_21799915_ChIP-Seq_A2780_Human1.24541686
49TAF15_26573619_Chip-Seq_HEK293_Human1.22289044
50* AR_19668381_ChIP-Seq_PC3_Human1.18293465
51WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17961899
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15730832
53RING1B_27294783_Chip-Seq_NPCs_Mouse1.15689115
54GATA1_26923725_Chip-Seq_HPCs_Mouse1.13759722
55KDM2B_26808549_Chip-Seq_K562_Human1.13522320
56* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13144037
57* SOX2_21211035_ChIP-Seq_LN229_Gbm1.12883199
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11469240
59YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10838340
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08066077
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08066077
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.06733993
63* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06411814
64TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05541903
65ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03835199
66OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03377033
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02230292
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01234921
69MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99724507
70* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99698474
71* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97704166
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97607027
73WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96958128
74TET1_21490601_ChIP-Seq_MESCs_Mouse0.96413631
75CTCF_27219007_Chip-Seq_Bcells_Human0.95738637
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93449298
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93188765
78P300_19829295_ChIP-Seq_ESCs_Human0.91190282
79LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91128507
80* AR_25329375_ChIP-Seq_VCAP_Human0.89858050
81* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89384361
82P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89334289
83* TCF4_23295773_ChIP-Seq_U87_Human0.89151938
84CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89109470
85* STAT3_23295773_ChIP-Seq_U87_Human0.88776489
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87370326
87CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86199806
88TP53_20018659_ChIP-ChIP_R1E_Mouse0.85779568
89* SMAD3_21741376_ChIP-Seq_ESCs_Human0.85496755
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82843724
91KDM2B_26808549_Chip-Seq_REH_Human0.82499755
92EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.82316556
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81968744
94SMAD4_21741376_ChIP-Seq_HESCs_Human0.81697822
95SOX9_26525672_Chip-Seq_HEART_Mouse0.81033002
96* PIAS1_25552417_ChIP-Seq_VCAP_Human0.80619327
97IGF1R_20145208_ChIP-Seq_DFB_Human0.78696746
98* PRDM14_20953172_ChIP-Seq_ESCs_Human0.77900984
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.77452790
100FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.77227452

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.51452961
2MP0003880_abnormal_central_pattern5.20210291
3MP0004270_analgesia4.64881266
4MP0003635_abnormal_synaptic_transmissio4.11812551
5MP0005423_abnormal_somatic_nervous3.98183451
6MP0002064_seizures3.54781443
7MP0009745_abnormal_behavioral_response3.39536488
8MP0002063_abnormal_learning/memory/cond3.28406650
9MP0001968_abnormal_touch/_nociception3.14730354
10MP0002734_abnormal_mechanical_nocicepti3.07271378
11MP0009046_muscle_twitch3.04804121
12MP0002272_abnormal_nervous_system3.02829813
13MP0001486_abnormal_startle_reflex2.80757239
14MP0002572_abnormal_emotion/affect_behav2.76771259
15MP0002735_abnormal_chemical_nociception2.66000690
16MP0002736_abnormal_nociception_after2.60184527
17MP0001501_abnormal_sleep_pattern2.36784927
18MP0008569_lethality_at_weaning2.32578996
19MP0003329_amyloid_beta_deposits2.22115094
20MP0001970_abnormal_pain_threshold2.11255614
21MP0003879_abnormal_hair_cell2.05512270
22MP0002733_abnormal_thermal_nociception2.01362907
23MP0002067_abnormal_sensory_capabilities1.93836889
24MP0003787_abnormal_imprinting1.92381076
25MP0001440_abnormal_grooming_behavior1.88767864
26MP0000778_abnormal_nervous_system1.85021941
27MP0003122_maternal_imprinting1.75299728
28MP0004811_abnormal_neuron_physiology1.71969090
29MP0002557_abnormal_social/conspecific_i1.70997238
30MP0006276_abnormal_autonomic_nervous1.68198012
31MP0004885_abnormal_endolymph1.66232413
32MP0004924_abnormal_behavior1.59454985
33MP0005386_behavior/neurological_phenoty1.59454985
34MP0005646_abnormal_pituitary_gland1.56821758
35MP0001502_abnormal_circadian_rhythm1.55019762
36MP0002066_abnormal_motor_capabilities/c1.51162660
37MP0003633_abnormal_nervous_system1.50636826
38MP0000955_abnormal_spinal_cord1.50334327
39MP0002882_abnormal_neuron_morphology1.47218006
40MP0004742_abnormal_vestibular_system1.44611631
41MP0001984_abnormal_olfaction1.44523452
42MP0002184_abnormal_innervation1.41684022
43MP0003690_abnormal_glial_cell1.40713956
44MP0009780_abnormal_chondrocyte_physiolo1.37454648
45MP0001529_abnormal_vocalization1.37173271
46MP0000920_abnormal_myelination1.34054271
47MP0001905_abnormal_dopamine_level1.33643381
48MP0003631_nervous_system_phenotype1.33006278
49MP0003123_paternal_imprinting1.28923359
50MP0001177_atelectasis1.26225417
51MP0002152_abnormal_brain_morphology1.13698922
52MP0002822_catalepsy1.13302040
53MP0003634_abnormal_glial_cell1.08238255
54MP0002229_neurodegeneration1.03509250
55MP0005551_abnormal_eye_electrophysiolog1.02571825
56MP0003632_abnormal_nervous_system1.02266485
57MP0000604_amyloidosis0.99325811
58MP0001963_abnormal_hearing_physiology0.98832164
59MP0004142_abnormal_muscle_tone0.96354217
60MP0003121_genomic_imprinting0.92884577
61MP0001188_hyperpigmentation0.92364393
62MP0008877_abnormal_DNA_methylation0.92009151
63MP0004147_increased_porphyrin_level0.91027737
64MP0002638_abnormal_pupillary_reflex0.89533574
65MP0002909_abnormal_adrenal_gland0.86881039
66MP0008874_decreased_physiological_sensi0.83771386
67MP0001485_abnormal_pinna_reflex0.79848143
68MP0002069_abnormal_eating/drinking_beha0.77310029
69MP0002752_abnormal_somatic_nervous0.75125106
70MP0005645_abnormal_hypothalamus_physiol0.73719066
71MP0005623_abnormal_meninges_morphology0.73251238
72MP0008872_abnormal_physiological_respon0.70948538
73MP0005535_abnormal_body_temperature0.69952424
74MP0001986_abnormal_taste_sensitivity0.67689431
75MP0001346_abnormal_lacrimal_gland0.67460854
76MP0000631_abnormal_neuroendocrine_gland0.66305541
77MP0010386_abnormal_urinary_bladder0.66052235
78MP0000569_abnormal_digit_pigmentation0.64417878
79MP0003861_abnormal_nervous_system0.61948621
80MP0010769_abnormal_survival0.61389934
81MP0005167_abnormal_blood-brain_barrier0.61274889
82MP0002082_postnatal_lethality0.58771040
83MP0010770_preweaning_lethality0.58771040
84MP0005409_darkened_coat_color0.58565555
85MP0010768_mortality/aging0.58174218
86MP0004043_abnormal_pH_regulation0.57175508
87MP0000026_abnormal_inner_ear0.57011402
88MP0001943_abnormal_respiration0.55758292
89MP0004085_abnormal_heartbeat0.54185597
90MP0001348_abnormal_lacrimal_gland0.52439894
91MP0002090_abnormal_vision0.51672412
92MP0000579_abnormal_nail_morphology0.50967367
93MP0003956_abnormal_body_size0.50670331
94MP0003075_altered_response_to0.49542829
95MP0001299_abnormal_eye_distance/0.49169112
96MP0003137_abnormal_impulse_conducting0.46973673
97MP0005253_abnormal_eye_physiology0.46899275
98MP0004215_abnormal_myocardial_fiber0.46242713
99MP0005499_abnormal_olfactory_system0.45022118
100MP0005394_taste/olfaction_phenotype0.45022118

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.62610117
2Focal motor seizures (HP:0011153)8.33028513
3Focal seizures (HP:0007359)6.80207714
4Febrile seizures (HP:0002373)6.02762172
5Atonic seizures (HP:0010819)5.76459637
6Epileptic encephalopathy (HP:0200134)5.48403207
7Action tremor (HP:0002345)5.40413611
8Supranuclear gaze palsy (HP:0000605)4.82480846
9Diplopia (HP:0000651)4.72251269
10Abnormality of binocular vision (HP:0011514)4.72251269
11Generalized tonic-clonic seizures (HP:0002069)4.48027758
12Limb dystonia (HP:0002451)4.18927639
13Progressive cerebellar ataxia (HP:0002073)4.18509240
14Dialeptic seizures (HP:0011146)4.11481912
15Neurofibrillary tangles (HP:0002185)4.11389986
16Absence seizures (HP:0002121)3.98724775
17Abnormal eating behavior (HP:0100738)3.94616126
18Ankle clonus (HP:0011448)3.94417918
19Visual hallucinations (HP:0002367)3.67985605
20Mutism (HP:0002300)3.65398406
21Torticollis (HP:0000473)3.64014951
22Spastic gait (HP:0002064)3.58382609
23Postural instability (HP:0002172)3.35047451
24Cerebral inclusion bodies (HP:0100314)3.23703379
25Hemiplegia (HP:0002301)3.13904095
26Truncal ataxia (HP:0002078)3.12456765
27Dysmetria (HP:0001310)3.11864501
28Status epilepticus (HP:0002133)3.11306858
29Akinesia (HP:0002304)3.10240284
30Cerebral hypomyelination (HP:0006808)3.07105014
31Papilledema (HP:0001085)3.06817017
32Urinary bladder sphincter dysfunction (HP:0002839)3.03494717
33Epileptiform EEG discharges (HP:0011182)2.94529828
34Focal dystonia (HP:0004373)2.94145976
35Annular pancreas (HP:0001734)2.93837091
36Impaired vibration sensation in the lower limbs (HP:0002166)2.91189702
37Poor eye contact (HP:0000817)2.89022031
38Obstructive sleep apnea (HP:0002870)2.86823173
39Intention tremor (HP:0002080)2.83504225
40Depression (HP:0000716)2.83015855
41Anxiety (HP:0000739)2.81248544
42Hemiparesis (HP:0001269)2.80307168
43Polyphagia (HP:0002591)2.77765354
44Abnormality of the corticospinal tract (HP:0002492)2.77252718
45Urinary urgency (HP:0000012)2.76180293
46Craniofacial dystonia (HP:0012179)2.73370051
47Dysdiadochokinesis (HP:0002075)2.69507029
48EEG with generalized epileptiform discharges (HP:0011198)2.62692971
49Bradykinesia (HP:0002067)2.61301662
50Abnormality of the lower motor neuron (HP:0002366)2.55933031
51Broad-based gait (HP:0002136)2.55649922
52Impaired social interactions (HP:0000735)2.54101452
53Abnormal social behavior (HP:0012433)2.54101452
54Tetraplegia (HP:0002445)2.54017723
55Hypsarrhythmia (HP:0002521)2.51919477
56Amblyopia (HP:0000646)2.51104420
57Neuronal loss in central nervous system (HP:0002529)2.51020273
58Drooling (HP:0002307)2.50426337
59Sleep apnea (HP:0010535)2.49738711
60Delusions (HP:0000746)2.49426486
61Impaired smooth pursuit (HP:0007772)2.48716036
62Lower limb muscle weakness (HP:0007340)2.43234353
63Peripheral hypomyelination (HP:0007182)2.36973352
64Amyotrophic lateral sclerosis (HP:0007354)2.36629881
65Apathy (HP:0000741)2.36618937
66Spastic tetraparesis (HP:0001285)2.33740912
67Hyperventilation (HP:0002883)2.32507419
68Excessive salivation (HP:0003781)2.32216633
69Gaze-evoked nystagmus (HP:0000640)2.31418353
70Stereotypic behavior (HP:0000733)2.23810323
71Clonus (HP:0002169)2.23438873
72Morphological abnormality of the pyramidal tract (HP:0002062)2.15233170
73Abnormality of ocular smooth pursuit (HP:0000617)2.15023506
74Rigidity (HP:0002063)2.14557099
75Diminished motivation (HP:0000745)2.14060420
76Absent speech (HP:0001344)2.10602170
77Impaired vibratory sensation (HP:0002495)2.07393483
78Incomplete penetrance (HP:0003829)2.02743679
79Scanning speech (HP:0002168)2.01954893
80Degeneration of the lateral corticospinal tracts (HP:0002314)1.99257479
81Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.99257479
82Choreoathetosis (HP:0001266)1.95049606
83Fetal akinesia sequence (HP:0001989)1.94469799
84Rapidly progressive (HP:0003678)1.90743926
85Insomnia (HP:0100785)1.88812938
86Spastic tetraplegia (HP:0002510)1.87130450
87Increased circulating renin level (HP:0000848)1.85065478
88Genetic anticipation (HP:0003743)1.84334876
89CNS hypomyelination (HP:0003429)1.84062889
90Abnormality of saccadic eye movements (HP:0000570)1.82152506
91Memory impairment (HP:0002354)1.81374913
92Megalencephaly (HP:0001355)1.81319665
93Ventricular fibrillation (HP:0001663)1.79309881
94Prolonged QT interval (HP:0001657)1.78831138
95Gait imbalance (HP:0002141)1.77697108
96Split foot (HP:0001839)1.75719270
97Abnormal EKG (HP:0003115)1.72992970
98Dysmetric saccades (HP:0000641)1.72296443
99Lower limb asymmetry (HP:0100559)1.69890784
100Gait ataxia (HP:0002066)1.69812276

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.99175463
2EPHA44.92577666
3NTRK33.99119440
4DAPK23.55725665
5PAK63.49714864
6NTRK23.06776718
7CASK2.63139739
8MAP3K92.58208491
9UHMK12.55791822
10MINK12.46640526
11MAPK132.43722546
12CAMKK12.41631194
13PRKD32.02412232
14NTRK11.95167433
15SIK21.95164985
16CAMKK21.73049611
17PHKG11.64328148
18PHKG21.64328148
19CDK51.60601243
20SGK2231.50316756
21SGK4941.50316756
22PLK21.47163075
23PRKCG1.44152674
24LATS21.43950691
25TNIK1.38233296
26DAPK11.32190173
27CAMK11.30542847
28CAMK2B1.30029873
29CDK191.29546411
30SGK21.28515442
31KSR21.27974430
32TYRO31.22378631
33GRK51.21762029
34RIPK11.17505517
35DYRK1A1.16132708
36CDK151.14275752
37CAMK2A1.12971159
38PRKCH1.12935334
39CDK181.11235648
40PINK11.10904089
41ARAF1.10044623
42PAK31.09692740
43MAP3K41.08411217
44CDK11A1.02788779
45CDK141.02009469
46SGK31.00197405
47MARK20.97990503
48PKN10.95003211
49CAMK40.93257780
50RIPK40.87544872
51SGK10.86547367
52MAPK120.83025154
53MAP2K70.81489581
54KSR10.79767745
55STK110.79014399
56CAMK2G0.74284842
57ALK0.73875118
58OXSR10.72005650
59MAP2K40.68100022
60NEK60.65680280
61PRKCZ0.62673583
62PRPF4B0.61738458
63PNCK0.60549058
64DYRK20.59781998
65WNK10.59732650
66RPS6KA30.58368206
67MAPK100.56622426
68CAMK2D0.55777239
69FGFR20.54466890
70STK380.53800320
71PDK10.52616875
72LIMK10.52181259
73MAP3K120.51649226
74CSNK1G20.50237510
75FYN0.48568946
76BRSK10.46038892
77RAF10.45916814
78ROCK20.45168815
79PDPK10.40400796
80DAPK30.39171886
81PRKCE0.39092689
82CCNB10.38233299
83BRAF0.38051035
84MAP3K130.35106352
85PRKCA0.33597300
86BMPR20.32736274
87PRKACA0.32546845
88TESK10.30459371
89RPS6KB10.30366244
90MAP3K110.30332622
91PRKCB0.30126707
92TNK20.30087028
93MAPK80.29691144
94FES0.28672479
95PRKG10.28546913
96CSNK1D0.27974337
97WNK30.27496243
98ERBB20.27183231
99IRAK20.27163583
100CSNK1E0.24878410

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.74715612
2Synaptic vesicle cycle_Homo sapiens_hsa047213.96476632
3Long-term potentiation_Homo sapiens_hsa047202.98207444
4GABAergic synapse_Homo sapiens_hsa047272.96050869
5Glutamatergic synapse_Homo sapiens_hsa047242.89019093
6Circadian entrainment_Homo sapiens_hsa047132.86965098
7Amphetamine addiction_Homo sapiens_hsa050312.83570274
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.76625596
9Morphine addiction_Homo sapiens_hsa050322.72178662
10Insulin secretion_Homo sapiens_hsa049112.43977451
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26284935
12Dopaminergic synapse_Homo sapiens_hsa047282.23322348
13Cocaine addiction_Homo sapiens_hsa050302.15454108
14Gastric acid secretion_Homo sapiens_hsa049711.99921606
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.95399281
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.93787624
17Cholinergic synapse_Homo sapiens_hsa047251.86758350
18Salivary secretion_Homo sapiens_hsa049701.80262297
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71272480
20Taste transduction_Homo sapiens_hsa047421.70269835
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.68344856
22Oxytocin signaling pathway_Homo sapiens_hsa049211.58853170
23Calcium signaling pathway_Homo sapiens_hsa040201.58093126
24Renin secretion_Homo sapiens_hsa049241.49397495
25cAMP signaling pathway_Homo sapiens_hsa040241.46925354
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46606525
27Long-term depression_Homo sapiens_hsa047301.46377070
28Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.42588091
29Serotonergic synapse_Homo sapiens_hsa047261.32164443
30Olfactory transduction_Homo sapiens_hsa047401.23316187
31Gap junction_Homo sapiens_hsa045401.20188409
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17901767
33Collecting duct acid secretion_Homo sapiens_hsa049661.17313569
34Vitamin B6 metabolism_Homo sapiens_hsa007501.14960406
35GnRH signaling pathway_Homo sapiens_hsa049121.13574331
36Estrogen signaling pathway_Homo sapiens_hsa049151.11322900
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09701832
38Phototransduction_Homo sapiens_hsa047441.06058926
39Cardiac muscle contraction_Homo sapiens_hsa042601.04064933
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03360750
41Melanogenesis_Homo sapiens_hsa049161.01143161
42Axon guidance_Homo sapiens_hsa043600.98227251
43cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95735782
44Type II diabetes mellitus_Homo sapiens_hsa049300.94773965
45Pancreatic secretion_Homo sapiens_hsa049720.93363698
46Glioma_Homo sapiens_hsa052140.92227412
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84579579
48Oocyte meiosis_Homo sapiens_hsa041140.84022027
49ErbB signaling pathway_Homo sapiens_hsa040120.83418399
50Bile secretion_Homo sapiens_hsa049760.83118460
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.82731904
52Thyroid hormone synthesis_Homo sapiens_hsa049180.81613653
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73130500
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72853652
55Vibrio cholerae infection_Homo sapiens_hsa051100.71883381
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70259921
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.69434656
58Prion diseases_Homo sapiens_hsa050200.68789361
59MAPK signaling pathway_Homo sapiens_hsa040100.66485060
60Ras signaling pathway_Homo sapiens_hsa040140.66212862
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63735630
62Rap1 signaling pathway_Homo sapiens_hsa040150.61110059
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57402125
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.55873906
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54529787
66Inositol phosphate metabolism_Homo sapiens_hsa005620.53146560
67Circadian rhythm_Homo sapiens_hsa047100.51588562
68Alzheimers disease_Homo sapiens_hsa050100.50275330
69Glucagon signaling pathway_Homo sapiens_hsa049220.50251558
70VEGF signaling pathway_Homo sapiens_hsa043700.50002647
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49341655
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49259229
73Dorso-ventral axis formation_Homo sapiens_hsa043200.47085617
74Dilated cardiomyopathy_Homo sapiens_hsa054140.46799623
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44515135
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44137696
77Alcoholism_Homo sapiens_hsa050340.42851269
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.42743188
79Endocytosis_Homo sapiens_hsa041440.42592656
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41330321
81Choline metabolism in cancer_Homo sapiens_hsa052310.40573119
82Fatty acid biosynthesis_Homo sapiens_hsa000610.40234816
83Arginine biosynthesis_Homo sapiens_hsa002200.36220747
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35504062
85Ovarian steroidogenesis_Homo sapiens_hsa049130.34564738
86Wnt signaling pathway_Homo sapiens_hsa043100.33674444
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30478692
88Mineral absorption_Homo sapiens_hsa049780.29766125
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25368021
90Arginine and proline metabolism_Homo sapiens_hsa003300.24698874
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23546763
92mTOR signaling pathway_Homo sapiens_hsa041500.21577154
93Tight junction_Homo sapiens_hsa045300.21523006
94AMPK signaling pathway_Homo sapiens_hsa041520.20189687
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19418734
96Renal cell carcinoma_Homo sapiens_hsa052110.18935494
97Endometrial cancer_Homo sapiens_hsa052130.18607842
98Insulin signaling pathway_Homo sapiens_hsa049100.17475105
99Histidine metabolism_Homo sapiens_hsa003400.17320290
100Ether lipid metabolism_Homo sapiens_hsa005650.16554984

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