CA11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)9.04139453
2synaptic vesicle docking involved in exocytosis (GO:0016081)8.89139540
3glutamate secretion (GO:0014047)8.04227026
4regulation of short-term neuronal synaptic plasticity (GO:0048172)7.33422274
5regulation of synaptic vesicle exocytosis (GO:2000300)7.22075789
6synaptic vesicle exocytosis (GO:0016079)7.21679731
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.23337154
8regulation of synaptic vesicle transport (GO:1902803)6.14891059
9cellular potassium ion homeostasis (GO:0030007)6.03758347
10neurotransmitter secretion (GO:0007269)5.91339739
11membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.88884997
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.59808107
13locomotory exploration behavior (GO:0035641)5.55889357
14regulation of neuronal synaptic plasticity (GO:0048168)5.52547031
15sodium ion export (GO:0071436)5.51807769
16L-amino acid import (GO:0043092)5.07623000
17positive regulation of synapse maturation (GO:0090129)5.03051920
18exploration behavior (GO:0035640)4.93734864
19vocalization behavior (GO:0071625)4.93015239
20regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.85356597
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.84106878
22neuronal action potential propagation (GO:0019227)4.79981547
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.79974062
24neurotransmitter transport (GO:0006836)4.72717215
25cerebellar granule cell differentiation (GO:0021707)4.62830450
26ionotropic glutamate receptor signaling pathway (GO:0035235)4.57324694
27amino acid import (GO:0043090)4.51957603
28regulation of glutamate receptor signaling pathway (GO:1900449)4.50052724
29positive regulation of dendritic spine development (GO:0060999)4.46438843
30protein localization to synapse (GO:0035418)4.43204176
31regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.35298532
32regulation of neurotransmitter secretion (GO:0046928)4.34808680
33synaptic transmission, glutamatergic (GO:0035249)4.31065334
34neuronal ion channel clustering (GO:0045161)4.31043588
35axon ensheathment in central nervous system (GO:0032291)4.30821218
36central nervous system myelination (GO:0022010)4.30821218
37dendritic spine morphogenesis (GO:0060997)4.26070377
38positive regulation of membrane potential (GO:0045838)4.25698627
39regulation of neurotransmitter levels (GO:0001505)4.23499480
40potassium ion homeostasis (GO:0055075)4.22502781
41cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.21658242
42positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.17298818
43regulation of synaptic plasticity (GO:0048167)4.15239977
44regulation of synapse structural plasticity (GO:0051823)4.14473044
45regulation of voltage-gated calcium channel activity (GO:1901385)4.13934592
46negative regulation of synaptic transmission, GABAergic (GO:0032229)4.11250571
47postsynaptic membrane organization (GO:0001941)4.09402334
48neuromuscular process controlling balance (GO:0050885)4.09062872
49regulation of excitatory postsynaptic membrane potential (GO:0060079)4.08325744
50neurotransmitter-gated ion channel clustering (GO:0072578)4.07897791
51positive regulation of neurotransmitter transport (GO:0051590)4.04979296
52synaptic vesicle endocytosis (GO:0048488)4.04013549
53potassium ion import (GO:0010107)4.03152954
54positive regulation of dendritic spine morphogenesis (GO:0061003)4.02309266
55positive regulation of neurotransmitter secretion (GO:0001956)3.95666927
56regulation of synapse maturation (GO:0090128)3.93382230
57regulation of neurotransmitter transport (GO:0051588)3.92794224
58cerebellar Purkinje cell differentiation (GO:0021702)3.91226145
59regulation of vesicle fusion (GO:0031338)3.89503594
60regulation of ARF protein signal transduction (GO:0032012)3.88126773
61neuron-neuron synaptic transmission (GO:0007270)3.86657977
62gamma-aminobutyric acid transport (GO:0015812)3.83057178
63negative regulation of dendrite morphogenesis (GO:0050774)3.80031715
64regulation of postsynaptic membrane potential (GO:0060078)3.77577694
65cell communication by electrical coupling (GO:0010644)3.77082797
66layer formation in cerebral cortex (GO:0021819)3.75465386
67regulation of dendritic spine morphogenesis (GO:0061001)3.74249013
68neuron cell-cell adhesion (GO:0007158)3.74032090
69glutamate receptor signaling pathway (GO:0007215)3.59424923
70regulation of dendritic spine development (GO:0060998)3.57619246
71long-term memory (GO:0007616)3.56345579
72cellular sodium ion homeostasis (GO:0006883)3.50001262
73dendritic spine organization (GO:0097061)3.49708904
74proline transport (GO:0015824)3.49312982
75gamma-aminobutyric acid signaling pathway (GO:0007214)3.48096046
76neuromuscular process controlling posture (GO:0050884)3.39846290
77membrane depolarization (GO:0051899)3.37664591
78acidic amino acid transport (GO:0015800)3.37285305
79G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.36118435
80neurotransmitter uptake (GO:0001504)3.35177174
81regulation of synaptic transmission (GO:0050804)3.34399960
82transmission of nerve impulse (GO:0019226)3.31162640
83auditory behavior (GO:0031223)3.29860065
84membrane depolarization during action potential (GO:0086010)3.29723467
85neuromuscular synaptic transmission (GO:0007274)3.26468711
86synaptic vesicle transport (GO:0048489)3.20006225
87establishment of synaptic vesicle localization (GO:0097480)3.20006225
88synaptic transmission (GO:0007268)3.19368405
89cell migration in hindbrain (GO:0021535)3.19081953
90vesicle docking involved in exocytosis (GO:0006904)3.15931533
91cytoskeletal anchoring at plasma membrane (GO:0007016)3.11993718
92regulation of exocytosis (GO:0017157)3.10705903
93neuromuscular process (GO:0050905)3.10164657
94chemosensory behavior (GO:0007635)3.10036796
95positive regulation of dendrite development (GO:1900006)3.09593661
96long-term synaptic potentiation (GO:0060291)3.07224153
97cell differentiation in hindbrain (GO:0021533)3.07031232
98cerebellar Purkinje cell layer development (GO:0021680)3.05948400
99dicarboxylic acid transport (GO:0006835)3.05703706
100signal release (GO:0023061)3.01010079

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.47349451
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.27767625
3RARB_27405468_Chip-Seq_BRAIN_Mouse3.46789026
4REST_21632747_ChIP-Seq_MESCs_Mouse3.44343304
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.22701716
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.21227807
7JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11179307
8DROSHA_22980978_ChIP-Seq_HELA_Human3.10596296
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03120751
10SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.91029281
11REST_18959480_ChIP-ChIP_MESCs_Mouse2.90009969
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.89937851
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.84913025
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.83031935
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.83031935
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.80538498
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.79505434
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.75956121
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.67554569
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.65086432
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.63411879
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.63032050
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48234361
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.41151597
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.40483683
26RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.34763503
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.30944622
28ZFP281_18757296_ChIP-ChIP_E14_Mouse2.19052476
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.14618083
30RCOR3_21632747_ChIP-Seq_MESCs_Mouse2.12497820
31ERG_21242973_ChIP-ChIP_JURKAT_Human2.05098849
32KDM2B_26808549_Chip-Seq_K562_Human1.90735858
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.88309368
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72606514
35* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.62099597
36ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.58277811
37ZFP281_27345836_Chip-Seq_ESCs_Mouse1.55299035
38RING1B_27294783_Chip-Seq_ESCs_Mouse1.55227290
39CTCF_27219007_Chip-Seq_Bcells_Human1.53085500
40GBX2_23144817_ChIP-Seq_PC3_Human1.48982726
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.47547734
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.46613198
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.43731160
44TET1_21490601_ChIP-Seq_MESCs_Mouse1.43382402
45SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.40402926
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35621981
47LXR_22292898_ChIP-Seq_THP-1_Human1.34651357
48GATA1_26923725_Chip-Seq_HPCs_Mouse1.26342740
49OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.24467420
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21275311
51AR_21572438_ChIP-Seq_LNCaP_Human1.21058437
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20679653
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20452334
54RING1B_27294783_Chip-Seq_NPCs_Mouse1.19251248
55WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16998007
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16547970
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13397943
58OCT4_19829295_ChIP-Seq_ESCs_Human1.12565159
59SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10592513
60SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.07492628
61SMC4_20622854_ChIP-Seq_HELA_Human1.05470918
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05175723
63AR_19668381_ChIP-Seq_PC3_Human1.04861983
64RNF2_27304074_Chip-Seq_NSC_Mouse1.03318469
65SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03117744
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.00742525
67NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99789395
68DPY_21335234_ChIP-Seq_ESCs_Mouse0.99036798
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98621358
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96864157
71P68_20966046_ChIP-Seq_HELA_Human0.95820159
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95575759
73* CREB1_26743006_Chip-Seq_LNCaP_Human0.92311155
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91287179
75PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90834838
76KLF4_19829295_ChIP-Seq_ESCs_Human0.90663137
77PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90296385
78TP53_20018659_ChIP-ChIP_R1E_Mouse0.89316451
79EGR1_19032775_ChIP-ChIP_M12_Human0.89152691
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87796750
81KDM2B_26808549_Chip-Seq_DND41_Human0.87015610
82CBX2_27304074_Chip-Seq_ESCs_Mouse0.83375231
83SMAD4_21741376_ChIP-Seq_ESCs_Human0.83127428
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.82906009
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.82418529
86P53_22127205_ChIP-Seq_FIBROBLAST_Human0.81704037
87RUNX1_26923725_Chip-Seq_HPCs_Mouse0.80410363
88SOX2_21211035_ChIP-Seq_LN229_Gbm0.76928771
89MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.76700907
90TET1_21451524_ChIP-Seq_MESCs_Mouse0.76424092
91KDM2B_26808549_Chip-Seq_JURKAT_Human0.75470565
92MYC_19915707_ChIP-ChIP_AK7_Human0.73660274
93SA1_27219007_Chip-Seq_Bcells_Human0.73588388
94YAP1_20516196_ChIP-Seq_MESCs_Mouse0.73409803
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73326486
96GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.72702762
97NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.72534913
98SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.71944271
99BMI1_23680149_ChIP-Seq_NPCS_Mouse0.71524629
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70879130

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.15159238
2MP0003880_abnormal_central_pattern5.65532095
3MP0004270_analgesia4.54459052
4MP0003635_abnormal_synaptic_transmissio4.22854649
5MP0005423_abnormal_somatic_nervous3.92901504
6MP0002064_seizures3.78566553
7MP0009745_abnormal_behavioral_response3.45426007
8MP0002063_abnormal_learning/memory/cond3.36252235
9MP0002272_abnormal_nervous_system3.07364456
10MP0001486_abnormal_startle_reflex2.93696817
11MP0002734_abnormal_mechanical_nocicepti2.93254517
12MP0009046_muscle_twitch2.84352327
13MP0001968_abnormal_touch/_nociception2.81249951
14MP0002572_abnormal_emotion/affect_behav2.76233343
15MP0008569_lethality_at_weaning2.48212160
16MP0001501_abnormal_sleep_pattern2.34384504
17MP0003879_abnormal_hair_cell2.29168009
18MP0003329_amyloid_beta_deposits2.26507339
19MP0003787_abnormal_imprinting2.19127792
20MP0002736_abnormal_nociception_after2.18915697
21MP0001970_abnormal_pain_threshold2.02633114
22MP0002735_abnormal_chemical_nociception1.95252305
23MP0002733_abnormal_thermal_nociception1.91931766
24MP0009780_abnormal_chondrocyte_physiolo1.83970526
25MP0004811_abnormal_neuron_physiology1.81789281
26MP0001440_abnormal_grooming_behavior1.78054921
27MP0003123_paternal_imprinting1.77723759
28MP0003690_abnormal_glial_cell1.73183625
29MP0002557_abnormal_social/conspecific_i1.70365973
30MP0004885_abnormal_endolymph1.69930617
31MP0002067_abnormal_sensory_capabilities1.68365328
32MP0000920_abnormal_myelination1.63407369
33MP0003633_abnormal_nervous_system1.59903158
34MP0000778_abnormal_nervous_system1.57046627
35MP0005646_abnormal_pituitary_gland1.56810066
36MP0002066_abnormal_motor_capabilities/c1.52540365
37MP0006276_abnormal_autonomic_nervous1.51680344
38MP0001502_abnormal_circadian_rhythm1.49682869
39MP0003122_maternal_imprinting1.49198806
40MP0002882_abnormal_neuron_morphology1.44651819
41MP0000955_abnormal_spinal_cord1.41782791
42MP0003631_nervous_system_phenotype1.34796240
43MP0001905_abnormal_dopamine_level1.32447945
44MP0001177_atelectasis1.31644755
45MP0004924_abnormal_behavior1.29352525
46MP0005386_behavior/neurological_phenoty1.29352525
47MP0002822_catalepsy1.23817081
48MP0001984_abnormal_olfaction1.22698181
49MP0004742_abnormal_vestibular_system1.22478582
50MP0002184_abnormal_innervation1.21815284
51MP0002152_abnormal_brain_morphology1.11938266
52MP0002229_neurodegeneration1.08111568
53MP0003634_abnormal_glial_cell1.07637196
54MP0003075_altered_response_to1.06228490
55MP0001963_abnormal_hearing_physiology1.04922100
56MP0000604_amyloidosis1.00760247
57MP0001485_abnormal_pinna_reflex0.97902312
58MP0001346_abnormal_lacrimal_gland0.96905601
59MP0008877_abnormal_DNA_methylation0.96787112
60MP0004147_increased_porphyrin_level0.93716972
61MP0003632_abnormal_nervous_system0.92417511
62MP0008874_decreased_physiological_sensi0.90509893
63MP0001348_abnormal_lacrimal_gland0.90163958
64MP0005167_abnormal_blood-brain_barrier0.84358085
65MP0001188_hyperpigmentation0.83447091
66MP0002638_abnormal_pupillary_reflex0.82139616
67MP0005551_abnormal_eye_electrophysiolog0.79027386
68MP0002069_abnormal_eating/drinking_beha0.76951029
69MP0005535_abnormal_body_temperature0.74181700
70MP0003121_genomic_imprinting0.72326261
71MP0004130_abnormal_muscle_cell0.70241028
72MP0002752_abnormal_somatic_nervous0.68314616
73MP0000579_abnormal_nail_morphology0.66650312
74MP0001529_abnormal_vocalization0.66130688
75MP0001986_abnormal_taste_sensitivity0.65738679
76MP0002909_abnormal_adrenal_gland0.64255597
77MP0008872_abnormal_physiological_respon0.64028555
78MP0005623_abnormal_meninges_morphology0.63847100
79MP0004142_abnormal_muscle_tone0.60109063
80MP0003137_abnormal_impulse_conducting0.58708522
81MP0003938_abnormal_ear_development0.57978088
82MP0003283_abnormal_digestive_organ0.57628744
83MP0003861_abnormal_nervous_system0.56717026
84MP0010769_abnormal_survival0.55010056
85MP0000026_abnormal_inner_ear0.53656928
86MP0010386_abnormal_urinary_bladder0.53154293
87MP0002089_abnormal_postnatal_growth/wei0.52909826
88MP0001299_abnormal_eye_distance/0.52850938
89MP0000566_synostosis0.52520956
90MP0010768_mortality/aging0.51780685
91MP0001943_abnormal_respiration0.51243677
92MP0003172_abnormal_lysosome_physiology0.50036515
93MP0002082_postnatal_lethality0.49808672
94MP0010770_preweaning_lethality0.49808672
95MP0002090_abnormal_vision0.49714397
96MP0003956_abnormal_body_size0.49511525
97MP0005645_abnormal_hypothalamus_physiol0.49256548
98MP0002873_normal_phenotype0.48556437
99MP0005166_decreased_susceptibility_to0.48053941
100MP0002169_no_abnormal_phenotype0.47229253

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)9.06150175
2Focal motor seizures (HP:0011153)7.11356045
3Focal seizures (HP:0007359)6.35440196
4Febrile seizures (HP:0002373)5.43220068
5Action tremor (HP:0002345)5.42380916
6Epileptic encephalopathy (HP:0200134)5.28106032
7Atonic seizures (HP:0010819)5.21375789
8Supranuclear gaze palsy (HP:0000605)5.15042468
9Abnormality of binocular vision (HP:0011514)5.06618993
10Diplopia (HP:0000651)5.06618993
11Ankle clonus (HP:0011448)4.82374515
12Visual hallucinations (HP:0002367)4.57881316
13Neurofibrillary tangles (HP:0002185)4.19548614
14Generalized tonic-clonic seizures (HP:0002069)4.16600092
15Progressive cerebellar ataxia (HP:0002073)4.04097514
16Annular pancreas (HP:0001734)3.90250963
17Abnormal eating behavior (HP:0100738)3.89923222
18Spastic gait (HP:0002064)3.86763151
19Cerebral hypomyelination (HP:0006808)3.74733463
20Torticollis (HP:0000473)3.68311901
21Absence seizures (HP:0002121)3.65703665
22Papilledema (HP:0001085)3.64812314
23Urinary bladder sphincter dysfunction (HP:0002839)3.57934390
24Mutism (HP:0002300)3.54046396
25Obstructive sleep apnea (HP:0002870)3.50381064
26Dialeptic seizures (HP:0011146)3.46478462
27Tetraplegia (HP:0002445)3.45783204
28Limb dystonia (HP:0002451)3.43054914
29Dysmetria (HP:0001310)3.40780931
30Impaired vibration sensation in the lower limbs (HP:0002166)3.40123952
31Delusions (HP:0000746)3.40080403
32Postural instability (HP:0002172)3.39646477
33Cerebral inclusion bodies (HP:0100314)3.39355623
34Focal dystonia (HP:0004373)3.31068353
35Intention tremor (HP:0002080)3.21044400
36Depression (HP:0000716)3.17566591
37Truncal ataxia (HP:0002078)3.16625836
38Status epilepticus (HP:0002133)3.10119227
39Hemiplegia (HP:0002301)3.04405024
40Craniofacial dystonia (HP:0012179)3.00169489
41Neuronal loss in central nervous system (HP:0002529)2.99038948
42Anxiety (HP:0000739)2.95244703
43Urinary urgency (HP:0000012)2.87278031
44Poor eye contact (HP:0000817)2.85031513
45Bradykinesia (HP:0002067)2.84463542
46Sleep apnea (HP:0010535)2.80870343
47Akinesia (HP:0002304)2.78363425
48Epileptiform EEG discharges (HP:0011182)2.78228809
49Peripheral hypomyelination (HP:0007182)2.75005947
50Insomnia (HP:0100785)2.74564956
51Clonus (HP:0002169)2.72753586
52Apathy (HP:0000741)2.69753473
53Amblyopia (HP:0000646)2.62371325
54Lower limb muscle weakness (HP:0007340)2.59736834
55Abnormality of the corticospinal tract (HP:0002492)2.55002683
56Abnormality of the lower motor neuron (HP:0002366)2.54516867
57Abnormal social behavior (HP:0012433)2.48640077
58Impaired social interactions (HP:0000735)2.48640077
59Hemiparesis (HP:0001269)2.48544421
60Dysdiadochokinesis (HP:0002075)2.45403276
61Diminished motivation (HP:0000745)2.43168806
62EEG with generalized epileptiform discharges (HP:0011198)2.42001661
63Impaired smooth pursuit (HP:0007772)2.41716804
64Spastic tetraparesis (HP:0001285)2.40768440
65Rigidity (HP:0002063)2.36409041
66Stereotypic behavior (HP:0000733)2.30128091
67Polyphagia (HP:0002591)2.29818491
68Choreoathetosis (HP:0001266)2.27481123
69Impaired vibratory sensation (HP:0002495)2.27436957
70Hypsarrhythmia (HP:0002521)2.26492436
71CNS hypomyelination (HP:0003429)2.26171711
72Abnormality of ocular smooth pursuit (HP:0000617)2.15370121
73Ventricular fibrillation (HP:0001663)2.15315769
74Scanning speech (HP:0002168)2.12753538
75Aplasia of the phalanges of the hand (HP:0009802)2.12119842
76Aplasia involving bones of the extremities (HP:0009825)2.12119842
77Aplasia involving bones of the upper limbs (HP:0009823)2.12119842
78Incomplete penetrance (HP:0003829)2.09770513
79Lower limb asymmetry (HP:0100559)2.06684048
80Megalencephaly (HP:0001355)2.03613208
81Spinal canal stenosis (HP:0003416)2.02067070
82Increased circulating renin level (HP:0000848)1.99871760
83Split foot (HP:0001839)1.95500725
84Morphological abnormality of the pyramidal tract (HP:0002062)1.94878121
85Rapidly progressive (HP:0003678)1.94152314
86Degeneration of the lateral corticospinal tracts (HP:0002314)1.91359417
87Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.91359417
88Bronchomalacia (HP:0002780)1.88212195
89Turricephaly (HP:0000262)1.82439271
90Memory impairment (HP:0002354)1.82039683
91Pointed chin (HP:0000307)1.81847490
92Broad-based gait (HP:0002136)1.81449419
93Gaze-evoked nystagmus (HP:0000640)1.78294661
94Abnormality of saccadic eye movements (HP:0000570)1.78224474
95Dementia (HP:0000726)1.77796567
96Bundle branch block (HP:0011710)1.75290315
97Lower limb amyotrophy (HP:0007210)1.75247352
98Drooling (HP:0002307)1.74754854
99Hand muscle atrophy (HP:0009130)1.73686172
100Unsteady gait (HP:0002317)1.73152958

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.77236397
2PAK64.37068227
3NTRK34.02186487
4DAPK23.96847128
5MARK13.26121596
6UHMK12.88900179
7CAMKK12.61518940
8PRKD32.60852175
9MAP3K92.58849266
10MINK12.50133001
11NTRK22.39741091
12NTRK12.09433262
13RIPK12.03535732
14RIPK41.95245507
15GRK51.90080877
16PLK21.88087471
17ARAF1.75431034
18CDK191.69187758
19DAPK11.57625064
20CDK51.57564492
21LATS21.55162515
22CAMK11.53705861
23PRPF4B1.51847671
24TYRO31.38909592
25PRKCG1.35797363
26SIK21.34540586
27SGK2231.31858367
28SGK4941.31858367
29CASK1.28938858
30KSR21.26979533
31PINK11.26703550
32CDK151.23412348
33PRKCH1.21133673
34CDK181.18959829
35MAPK131.17125497
36PHKG21.16722042
37PHKG11.16722042
38ALK1.15755604
39CDK11A1.15299940
40CAMK2B1.13823413
41MARK21.10900795
42PAK31.10024216
43CDK141.09549665
44BRSK11.05265390
45STK110.97367545
46DYRK1A0.97128473
47NEK60.94493202
48STK380.92578282
49BMPR20.92339254
50CAMK2A0.91983398
51SGK20.90445076
52MAP3K110.87212388
53MAPK120.85975023
54CAMK2G0.84145940
55DAPK30.83462408
56SGK30.81549644
57CAMKK20.80636180
58BRAF0.77848629
59PKN10.74974232
60SGK10.72679882
61MAPK100.69891611
62CAMK40.69620039
63LIMK10.68756582
64OXSR10.64266831
65PDK10.63832981
66MAP3K130.63605081
67TNK20.62486907
68FGFR20.62126060
69PDPK10.61413581
70MAP2K40.56616262
71RPS6KA30.55492971
72MAP3K40.50225737
73PRKCZ0.49694856
74TESK10.46012906
75KSR10.45276224
76CAMK2D0.40563067
77FYN0.39980205
78MAP2K70.39968913
79RAF10.38820835
80PRKG20.38342797
81ROCK20.38111749
82FES0.37615144
83PRKCA0.34570018
84WNK10.32748633
85CSNK1G20.32539429
86MAP2K60.30701318
87MAP3K10.29866210
88MAPK80.28720509
89MAP3K120.28593296
90ERBB20.27477503
91CSNK1E0.25716392
92MAP3K20.25254480
93PRKCB0.24685546
94CAMK1G0.24637317
95MAPK40.24148471
96ROCK10.24009912
97GSK3B0.22966088
98IRAK20.22912723
99RET0.22753214
100SRC0.22359439

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.35331944
2Nicotine addiction_Homo sapiens_hsa050334.21285433
3Long-term potentiation_Homo sapiens_hsa047203.04799472
4Amphetamine addiction_Homo sapiens_hsa050312.85994383
5GABAergic synapse_Homo sapiens_hsa047272.81484799
6Circadian entrainment_Homo sapiens_hsa047132.77461564
7Morphine addiction_Homo sapiens_hsa050322.72307833
8Insulin secretion_Homo sapiens_hsa049112.68720939
9Glutamatergic synapse_Homo sapiens_hsa047242.64589640
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.61614218
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.56491262
12Dopaminergic synapse_Homo sapiens_hsa047282.21357080
13Gastric acid secretion_Homo sapiens_hsa049712.21116639
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.10863395
15Aldosterone synthesis and secretion_Homo sapiens_hsa049252.04626144
16Cocaine addiction_Homo sapiens_hsa050301.97520254
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.88682837
18Vitamin B6 metabolism_Homo sapiens_hsa007501.86640306
19Cholinergic synapse_Homo sapiens_hsa047251.86162722
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.80349879
21Salivary secretion_Homo sapiens_hsa049701.77711286
22Oxytocin signaling pathway_Homo sapiens_hsa049211.65957829
23Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.58388108
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.54752150
25Calcium signaling pathway_Homo sapiens_hsa040201.53934789
26cAMP signaling pathway_Homo sapiens_hsa040241.48540702
27Renin secretion_Homo sapiens_hsa049241.32066279
28GnRH signaling pathway_Homo sapiens_hsa049121.28320408
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27669130
30Long-term depression_Homo sapiens_hsa047301.27652493
31Taste transduction_Homo sapiens_hsa047421.21741029
32Olfactory transduction_Homo sapiens_hsa047401.20452221
33Glioma_Homo sapiens_hsa052141.18652954
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16578319
35Collecting duct acid secretion_Homo sapiens_hsa049661.15986985
36Melanogenesis_Homo sapiens_hsa049161.14652326
37Serotonergic synapse_Homo sapiens_hsa047261.14581438
38Cardiac muscle contraction_Homo sapiens_hsa042601.12645323
39Estrogen signaling pathway_Homo sapiens_hsa049151.09800417
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07627931
41ErbB signaling pathway_Homo sapiens_hsa040121.02354691
42Gap junction_Homo sapiens_hsa045401.01729637
43cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96716980
44Pancreatic secretion_Homo sapiens_hsa049720.95390149
45Oocyte meiosis_Homo sapiens_hsa041140.93839420
46Thyroid hormone synthesis_Homo sapiens_hsa049180.88676549
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.88040604
48Axon guidance_Homo sapiens_hsa043600.84056457
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82323009
50VEGF signaling pathway_Homo sapiens_hsa043700.77360168
51Bile secretion_Homo sapiens_hsa049760.77122547
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76792236
53Vibrio cholerae infection_Homo sapiens_hsa051100.76775324
54Type II diabetes mellitus_Homo sapiens_hsa049300.74283060
55Prion diseases_Homo sapiens_hsa050200.73939792
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72283391
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.69595209
58MAPK signaling pathway_Homo sapiens_hsa040100.69098128
59Phototransduction_Homo sapiens_hsa047440.68683598
60Rap1 signaling pathway_Homo sapiens_hsa040150.68295333
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.66329095
62Inositol phosphate metabolism_Homo sapiens_hsa005620.66083892
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62532155
64Glucagon signaling pathway_Homo sapiens_hsa049220.61663908
65Ras signaling pathway_Homo sapiens_hsa040140.61659904
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60040480
67Endocytosis_Homo sapiens_hsa041440.56487767
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56381730
69Arginine and proline metabolism_Homo sapiens_hsa003300.53385817
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53312444
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.53059056
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52301360
73Choline metabolism in cancer_Homo sapiens_hsa052310.48712524
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47314915
75Alzheimers disease_Homo sapiens_hsa050100.47231831
76Wnt signaling pathway_Homo sapiens_hsa043100.46337188
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45728406
78Dilated cardiomyopathy_Homo sapiens_hsa054140.43452377
79Alcoholism_Homo sapiens_hsa050340.41295371
80Arginine biosynthesis_Homo sapiens_hsa002200.40474461
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35507202
82mTOR signaling pathway_Homo sapiens_hsa041500.32463172
83Insulin signaling pathway_Homo sapiens_hsa049100.32227358
84Mineral absorption_Homo sapiens_hsa049780.31575156
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31040760
86Tight junction_Homo sapiens_hsa045300.29353478
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29341039
88Histidine metabolism_Homo sapiens_hsa003400.27992713
89Circadian rhythm_Homo sapiens_hsa047100.27336428
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25555377
91Hippo signaling pathway_Homo sapiens_hsa043900.24703270
92beta-Alanine metabolism_Homo sapiens_hsa004100.23635231
93HIF-1 signaling pathway_Homo sapiens_hsa040660.22964934
94AMPK signaling pathway_Homo sapiens_hsa041520.21377450
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21311334
96Dorso-ventral axis formation_Homo sapiens_hsa043200.20821241
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17171156
98Fatty acid biosynthesis_Homo sapiens_hsa000610.16839111
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.16477624
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.14897985

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