CA13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Carbonic anhydrases (CAs) are a family of zinc metalloenzymes. For background information on the CA family, see MIM 114800. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1indolalkylamine metabolic process (GO:0006586)4.03547880
2protein neddylation (GO:0045116)3.99617215
3platelet dense granule organization (GO:0060155)3.97595573
4thrombin receptor signaling pathway (GO:0070493)3.94461132
5regulation of memory T cell differentiation (GO:0043380)3.91961259
6tryptophan catabolic process (GO:0006569)3.83490309
7indole-containing compound catabolic process (GO:0042436)3.83490309
8indolalkylamine catabolic process (GO:0046218)3.83490309
9behavioral response to nicotine (GO:0035095)3.78728491
10L-fucose catabolic process (GO:0042355)3.78189432
11fucose catabolic process (GO:0019317)3.78189432
12L-fucose metabolic process (GO:0042354)3.78189432
13kynurenine metabolic process (GO:0070189)3.44340865
14amine catabolic process (GO:0009310)3.39534499
15cellular biogenic amine catabolic process (GO:0042402)3.39534499
16phosphatidylinositol acyl-chain remodeling (GO:0036149)3.35527865
17dopamine transport (GO:0015872)3.35156101
18tryptophan metabolic process (GO:0006568)3.33184631
19cellular ketone body metabolic process (GO:0046950)3.23971952
20signal peptide processing (GO:0006465)3.21163978
21response to pheromone (GO:0019236)3.18027068
22multicellular organism reproduction (GO:0032504)3.14008963
23detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.10356388
24regulation of guanylate cyclase activity (GO:0031282)3.04284770
25positive regulation of guanylate cyclase activity (GO:0031284)3.01462051
26nucleotide transmembrane transport (GO:1901679)3.01146169
27protein K11-linked deubiquitination (GO:0035871)2.99377876
28DNA deamination (GO:0045006)2.98543884
29regulation of lipoprotein metabolic process (GO:0050746)2.97900819
30phosphatidylserine acyl-chain remodeling (GO:0036150)2.96213518
31ketone body metabolic process (GO:1902224)2.94512711
32sulfation (GO:0051923)2.93991439
33indole-containing compound metabolic process (GO:0042430)2.92268026
34aromatic amino acid family catabolic process (GO:0009074)2.90435799
35drug catabolic process (GO:0042737)2.90351806
36epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.89719959
37exogenous drug catabolic process (GO:0042738)2.89506137
38detection of light stimulus involved in visual perception (GO:0050908)2.84264072
39detection of light stimulus involved in sensory perception (GO:0050962)2.84264072
40negative regulation of mast cell activation (GO:0033004)2.83684018
41regulation of cilium movement (GO:0003352)2.82587305
42water-soluble vitamin biosynthetic process (GO:0042364)2.80555471
43respiratory chain complex IV assembly (GO:0008535)2.76322390
44arginine metabolic process (GO:0006525)2.74570511
45kidney morphogenesis (GO:0060993)2.72317516
46S-adenosylmethionine metabolic process (GO:0046500)2.71660410
47organelle membrane fusion (GO:0090174)2.68587700
48phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.67020936
49photoreceptor cell maintenance (GO:0045494)2.66903094
50preassembly of GPI anchor in ER membrane (GO:0016254)2.65303663
51epithelial cilium movement (GO:0003351)2.62242179
52phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.60939418
53benzene-containing compound metabolic process (GO:0042537)2.59365169
54reflex (GO:0060004)2.58818011
55regulation of glucokinase activity (GO:0033131)2.58499312
56regulation of hexokinase activity (GO:1903299)2.58499312
57autophagic vacuole fusion (GO:0000046)2.58486361
58negative regulation of heart rate (GO:0010459)2.57809900
59negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.55841455
60piRNA metabolic process (GO:0034587)2.55624734
61purinergic nucleotide receptor signaling pathway (GO:0035590)2.54880054
62nonmotile primary cilium assembly (GO:0035058)2.54762805
63phosphatidylcholine acyl-chain remodeling (GO:0036151)2.53468499
64axoneme assembly (GO:0035082)2.52436787
65sphingoid metabolic process (GO:0046519)2.51434563
66positive regulation of glycolytic process (GO:0045821)2.50848624
67polyol catabolic process (GO:0046174)2.50274931
68cytidine deamination (GO:0009972)2.49685916
69cytidine metabolic process (GO:0046087)2.49685916
70cytidine catabolic process (GO:0006216)2.49685916
71mannosylation (GO:0097502)2.49154726
72protein localization to cilium (GO:0061512)2.49080973
73alkaloid metabolic process (GO:0009820)2.48884964
74magnesium ion transport (GO:0015693)2.48150171
75positive regulation of cAMP-mediated signaling (GO:0043950)2.43603500
76negative regulation of telomere maintenance (GO:0032205)2.43391778
77arginine catabolic process (GO:0006527)2.43261632
78negative regulation of appetite (GO:0032099)2.42541315
79negative regulation of response to food (GO:0032096)2.42541315
80thyroid hormone metabolic process (GO:0042403)2.41532712
81primary amino compound metabolic process (GO:1901160)2.41490709
82cilium organization (GO:0044782)2.40528730
83serotonin metabolic process (GO:0042428)2.40477616
84rRNA catabolic process (GO:0016075)2.40322280
85reverse cholesterol transport (GO:0043691)2.37402523
86cilium assembly (GO:0042384)2.36812101
87transepithelial transport (GO:0070633)2.36622164
88regulation of transmission of nerve impulse (GO:0051969)2.35905091
89high-density lipoprotein particle remodeling (GO:0034375)2.35590156
90regulation of triglyceride catabolic process (GO:0010896)2.35207230
91oxidative demethylation (GO:0070989)2.35049103
92aromatic amino acid family metabolic process (GO:0009072)2.34315245
93xenobiotic catabolic process (GO:0042178)2.33837312
94adenosine metabolic process (GO:0046085)2.33065464
95bile acid and bile salt transport (GO:0015721)2.32973090
96L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.32342040
97regulation of protein glycosylation (GO:0060049)2.30780841
98cytochrome complex assembly (GO:0017004)2.27914416
99rhodopsin mediated signaling pathway (GO:0016056)2.26727982
100glycerophospholipid catabolic process (GO:0046475)2.26396841

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.09097252
2ZNF274_21170338_ChIP-Seq_K562_Hela2.98961942
3* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.59577542
4GBX2_23144817_ChIP-Seq_PC3_Human2.58431719
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.38962688
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34050544
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24551694
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04998176
9TAF15_26573619_Chip-Seq_HEK293_Human2.03118712
10P300_19829295_ChIP-Seq_ESCs_Human1.95571598
11PCGF2_27294783_Chip-Seq_ESCs_Mouse1.93432435
12AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.93035718
13EWS_26573619_Chip-Seq_HEK293_Human1.89451106
14IGF1R_20145208_ChIP-Seq_DFB_Human1.87511741
15FUS_26573619_Chip-Seq_HEK293_Human1.87372955
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85849646
17ER_23166858_ChIP-Seq_MCF-7_Human1.81012351
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79817692
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78840927
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.74248858
21EGR1_23403033_ChIP-Seq_LIVER_Mouse1.66750764
22UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64497638
23BCAT_22108803_ChIP-Seq_LS180_Human1.61606512
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60933354
25SMAD4_21799915_ChIP-Seq_A2780_Human1.57164709
26* PIAS1_25552417_ChIP-Seq_VCAP_Human1.56243452
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55808852
28NR3C1_21868756_ChIP-Seq_MCF10A_Human1.55600245
29STAT3_23295773_ChIP-Seq_U87_Human1.55473648
30EZH2_27294783_Chip-Seq_NPCs_Mouse1.54308467
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54143774
32AR_25329375_ChIP-Seq_VCAP_Human1.52832685
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.52641249
34NANOG_19829295_ChIP-Seq_ESCs_Human1.49598106
35SOX2_19829295_ChIP-Seq_ESCs_Human1.49598106
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.46954051
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.46469121
38CBP_20019798_ChIP-Seq_JUKART_Human1.46249800
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46249800
40TCF4_23295773_ChIP-Seq_U87_Human1.44650701
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.44347442
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.44347442
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43778914
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42598568
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41509272
46CDX2_22108803_ChIP-Seq_LS180_Human1.40278689
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39794924
48TCF4_22108803_ChIP-Seq_LS180_Human1.39380192
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38926020
50FOXA1_21572438_ChIP-Seq_LNCaP_Human1.38626627
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36808735
52TP53_22573176_ChIP-Seq_HFKS_Human1.35993588
53EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34077975
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32624756
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30893973
56CRX_20693478_ChIP-Seq_RETINA_Mouse1.30280750
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.30279379
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28843071
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27977773
60AR_20517297_ChIP-Seq_VCAP_Human1.27441443
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26652911
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26390273
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25211493
64P53_22387025_ChIP-Seq_ESCs_Mouse1.25018593
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.22149588
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.21933385
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20909752
68FLI1_21867929_ChIP-Seq_TH2_Mouse1.19192531
69KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18825401
70STAT3_18555785_Chip-Seq_ESCs_Mouse1.17185631
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.16897252
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.16794740
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16361646
74EZH2_22144423_ChIP-Seq_EOC_Human1.15531739
75RUNX2_22187159_ChIP-Seq_PCA_Human1.15410555
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12737224
77* GATA4_25053715_ChIP-Seq_YYC3_Human1.12277395
78SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11460620
79OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11140898
80NCOR_22424771_ChIP-Seq_293T_Human1.10781589
81AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10332761
82GATA1_22025678_ChIP-Seq_K562_Human1.08959660
83SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08452488
84E2F1_18555785_Chip-Seq_ESCs_Mouse1.07672910
85HTT_18923047_ChIP-ChIP_STHdh_Human1.07488341
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06638214
87* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06567755
88IRF1_19129219_ChIP-ChIP_H3396_Human1.06467278
89ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06464442
90CMYC_18555785_Chip-Seq_ESCs_Mouse1.06204774
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05875011
92GATA3_26560356_Chip-Seq_TH2_Human1.05771079
93PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03042730
94GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.02613919
95TAL1_26923725_Chip-Seq_HPCs_Mouse1.02265634
96FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01729828
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00252155
98NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00252155
99HOXB7_26014856_ChIP-Seq_BT474_Human0.99788344
100EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99763981

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.89660362
2MP0004147_increased_porphyrin_level3.59907152
3MP0005360_urolithiasis2.76747373
4MP0005085_abnormal_gallbladder_physiolo2.56866994
5MP0008872_abnormal_physiological_respon2.54974104
6MP0004043_abnormal_pH_regulation2.47484795
7MP0005464_abnormal_platelet_physiology2.32279608
8MP0005551_abnormal_eye_electrophysiolog2.17771542
9MP0005365_abnormal_bile_salt2.17400274
10MP0008875_abnormal_xenobiotic_pharmacok2.16669465
11MP0008877_abnormal_DNA_methylation2.06484210
12MP0002876_abnormal_thyroid_physiology2.02621525
13MP0003011_delayed_dark_adaptation1.98003527
14MP0002102_abnormal_ear_morphology1.97953884
15MP0001968_abnormal_touch/_nociception1.89773371
16MP0000372_irregular_coat_pigmentation1.88462869
17MP0002139_abnormal_hepatobiliary_system1.87613421
18MP0010329_abnormal_lipoprotein_level1.87118359
19MP0001501_abnormal_sleep_pattern1.85743677
20MP0002837_dystrophic_cardiac_calcinosis1.82359492
21MP0005646_abnormal_pituitary_gland1.81489733
22MP0005167_abnormal_blood-brain_barrier1.78854950
23MP0000230_abnormal_systemic_arterial1.73478942
24MP0002736_abnormal_nociception_after1.70192215
25MP0000427_abnormal_hair_cycle1.68509921
26MP0008004_abnormal_stomach_pH1.64850379
27MP0003718_maternal_effect1.63818748
28MP0005645_abnormal_hypothalamus_physiol1.62758248
29MP0000383_abnormal_hair_follicle1.59680972
30MP0005084_abnormal_gallbladder_morpholo1.58292129
31MP0002638_abnormal_pupillary_reflex1.56600051
32MP0003252_abnormal_bile_duct1.55511203
33MP0004019_abnormal_vitamin_homeostasis1.52061490
34MP0005174_abnormal_tail_pigmentation1.50974525
35MP0005253_abnormal_eye_physiology1.48937303
36MP0008775_abnormal_heart_ventricle1.48597220
37MP0002138_abnormal_hepatobiliary_system1.45693271
38MP0005332_abnormal_amino_acid1.43443570
39MP0000569_abnormal_digit_pigmentation1.40906900
40MP0009046_muscle_twitch1.39664189
41MP0005410_abnormal_fertilization1.39664059
42MP0004142_abnormal_muscle_tone1.38043064
43MP0001764_abnormal_homeostasis1.36682996
44MP0003724_increased_susceptibility_to1.35196546
45MP0006072_abnormal_retinal_apoptosis1.34958486
46MP0009697_abnormal_copulation1.33429040
47MP0001666_abnormal_nutrient_absorption1.33021228
48MP0001835_abnormal_antigen_presentation1.27908470
49MP0002733_abnormal_thermal_nociception1.27270211
50MP0010678_abnormal_skin_adnexa1.27090180
51MP0009764_decreased_sensitivity_to1.26473556
52MP0001765_abnormal_ion_homeostasis1.22364702
53MP0006276_abnormal_autonomic_nervous1.19132150
54MP0009745_abnormal_behavioral_response1.18644882
55MP0001664_abnormal_digestion1.18480742
56MP0004215_abnormal_myocardial_fiber1.14798159
57MP0005636_abnormal_mineral_homeostasis1.13878089
58MP0003950_abnormal_plasma_membrane1.13451138
59MP0002938_white_spotting1.12605640
60MP0001756_abnormal_urination1.11966207
61MP0010386_abnormal_urinary_bladder1.09347915
62MP0002693_abnormal_pancreas_physiology1.08972006
63MP0001986_abnormal_taste_sensitivity1.08269876
64MP0000516_abnormal_urinary_system1.07050296
65MP0005367_renal/urinary_system_phenotyp1.07050296
66MP0009643_abnormal_urine_homeostasis1.06082628
67MP0004885_abnormal_endolymph1.05371632
68MP0003646_muscle_fatigue1.04798984
69MP0005448_abnormal_energy_balance1.03363539
70MP0001905_abnormal_dopamine_level1.03241396
71MP0005386_behavior/neurological_phenoty1.02348681
72MP0004924_abnormal_behavior1.02348681
73MP0001970_abnormal_pain_threshold1.02220545
74MP0006054_spinal_hemorrhage1.02110885
75MP0005671_abnormal_response_to0.98757215
76MP0003638_abnormal_response/metabolism_0.98162332
77MP0005389_reproductive_system_phenotype0.97035265
78MP0003183_abnormal_peptide_metabolism0.96582452
79MP0003787_abnormal_imprinting0.96467788
80MP0005535_abnormal_body_temperature0.95644245
81MP0002118_abnormal_lipid_homeostasis0.94916984
82MP0002909_abnormal_adrenal_gland0.92701900
83MP0000647_abnormal_sebaceous_gland0.91865461
84MP0002095_abnormal_skin_pigmentation0.91774156
85MP0002272_abnormal_nervous_system0.91501716
86MP0004484_altered_response_of0.90590946
87MP0000015_abnormal_ear_pigmentation0.90442286
88MP0001919_abnormal_reproductive_system0.88913456
89MP0002735_abnormal_chemical_nociception0.86394943
90MP0006036_abnormal_mitochondrial_physio0.85232419
91MP0002148_abnormal_hypersensitivity_rea0.84135620
92MP0000465_gastrointestinal_hemorrhage0.82659339
93MP0001485_abnormal_pinna_reflex0.80264174
94MP0010155_abnormal_intestine_physiology0.79926568
95MP0005379_endocrine/exocrine_gland_phen0.79873496
96MP0002557_abnormal_social/conspecific_i0.79871242
97MP0004085_abnormal_heartbeat0.76549700
98MP0002136_abnormal_kidney_physiology0.76151354
99MP0001984_abnormal_olfaction0.76058364
100MP0000631_abnormal_neuroendocrine_gland0.75404561

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.15649974
2Pancreatic cysts (HP:0001737)3.90710508
3Abnormality of midbrain morphology (HP:0002418)3.74353331
4Molar tooth sign on MRI (HP:0002419)3.74353331
5True hermaphroditism (HP:0010459)3.51192840
6Abnormality of the renal cortex (HP:0011035)3.46824924
7Pancreatic fibrosis (HP:0100732)3.39687134
8Hypothermia (HP:0002045)3.12560125
9Medial flaring of the eyebrow (HP:0010747)3.10335022
10Petechiae (HP:0000967)2.94115463
11Renal cortical cysts (HP:0000803)2.92438897
12Prolonged bleeding time (HP:0003010)2.90262453
13Chronic hepatic failure (HP:0100626)2.89542457
14Nephronophthisis (HP:0000090)2.84932014
15Hyperventilation (HP:0002883)2.82017442
16Attenuation of retinal blood vessels (HP:0007843)2.76767532
17Decreased central vision (HP:0007663)2.71337687
18Abolished electroretinogram (ERG) (HP:0000550)2.68055929
19Abnormality of the renal medulla (HP:0100957)2.65638490
20Congenital sensorineural hearing impairment (HP:0008527)2.62382974
21Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.47711339
22Abnormality of alanine metabolism (HP:0010916)2.47711339
23Hyperalaninemia (HP:0003348)2.47711339
24Gait imbalance (HP:0002141)2.47455980
25Congenital primary aphakia (HP:0007707)2.46042137
26Menorrhagia (HP:0000132)2.39832944
273-Methylglutaconic aciduria (HP:0003535)2.39078939
28Abnormal drinking behavior (HP:0030082)2.36935290
29Polydipsia (HP:0001959)2.36935290
30Abnormality of glutamine family amino acid metabolism (HP:0010902)2.36877451
31Tubular atrophy (HP:0000092)2.36463309
32Abnormal rod and cone electroretinograms (HP:0008323)2.34574449
33Acanthocytosis (HP:0001927)2.34557861
34Nephrogenic diabetes insipidus (HP:0009806)2.33356875
35Decreased circulating renin level (HP:0003351)2.32355313
36Congenital, generalized hypertrichosis (HP:0004540)2.32072486
37Type II lissencephaly (HP:0007260)2.29179702
38Ketoacidosis (HP:0001993)2.22724154
39Increased mean platelet volume (HP:0011877)2.21766488
40Abnormality of urine glucose concentration (HP:0011016)2.20668166
41Glycosuria (HP:0003076)2.20668166
42Chorioretinal atrophy (HP:0000533)2.18933051
43Abnormality of vitamin B metabolism (HP:0004340)2.18177207
44Cystic liver disease (HP:0006706)2.16356927
45Abnormality of proline metabolism (HP:0010907)2.12057706
46Hydroxyprolinuria (HP:0003080)2.12057706
47Generalized aminoaciduria (HP:0002909)2.11271527
48Furrowed tongue (HP:0000221)2.09731816
49Large for gestational age (HP:0001520)2.09431125
50Abnormal biliary tract physiology (HP:0012439)2.08635215
51Bile duct proliferation (HP:0001408)2.08635215
52Metabolic alkalosis (HP:0200114)2.06102433
53Hypoplasia of the fovea (HP:0007750)2.04492534
54Aplasia/Hypoplasia of the fovea (HP:0008060)2.04492534
55Tongue fasciculations (HP:0001308)2.03521731
56Acute necrotizing encephalopathy (HP:0006965)2.02980192
57Hypomagnesemia (HP:0002917)1.99453155
58Acute encephalopathy (HP:0006846)1.98105460
59Decreased electroretinogram (ERG) amplitude (HP:0000654)1.96589614
60Congenital hepatic fibrosis (HP:0002612)1.95957156
61Microretrognathia (HP:0000308)1.95559761
62Gaze-evoked nystagmus (HP:0000640)1.95161913
63Genital tract atresia (HP:0001827)1.94808515
64Dyschromatopsia (HP:0007641)1.94002415
65Hyperlipoproteinemia (HP:0010980)1.93665658
66Progressive macrocephaly (HP:0004481)1.92755542
67Male pseudohermaphroditism (HP:0000037)1.92585098
68Pigmentary retinal degeneration (HP:0001146)1.92559933
69Abnormality of the vitamin B12 metabolism (HP:0004341)1.91285535
70Abnormality of macular pigmentation (HP:0008002)1.89840401
71Aplasia/Hypoplasia of the tongue (HP:0010295)1.89815145
72Mitochondrial inheritance (HP:0001427)1.89160766
73Polyuria (HP:0000103)1.89047866
74Stomach cancer (HP:0012126)1.88517623
75Abnormal platelet volume (HP:0011876)1.88173481
76Vaginal atresia (HP:0000148)1.87595906
77Poikilocytosis (HP:0004447)1.87402270
78Bony spicule pigmentary retinopathy (HP:0007737)1.87051223
79Absent/shortened dynein arms (HP:0200106)1.86201872
80Dynein arm defect of respiratory motile cilia (HP:0012255)1.86201872
81Increased CSF lactate (HP:0002490)1.86008035
82Hypoalbuminemia (HP:0003073)1.84755716
83Abnormal albumin level (HP:0012116)1.84755716
84Hypobetalipoproteinemia (HP:0003563)1.83619546
85Lissencephaly (HP:0001339)1.83378699
86Hyperglycinuria (HP:0003108)1.80998858
87Ketosis (HP:0001946)1.79208065
88Purpura (HP:0000979)1.76810149
89Inability to walk (HP:0002540)1.75575217
90Stomatitis (HP:0010280)1.74739921
91Fair hair (HP:0002286)1.74036968
92Sclerocornea (HP:0000647)1.72689996
93Febrile seizures (HP:0002373)1.71762467
94Clumsiness (HP:0002312)1.71641306
95Abnormal pupillary function (HP:0007686)1.71213385
96Abnormality of renin-angiotensin system (HP:0000847)1.69166601
97Progressive inability to walk (HP:0002505)1.68460447
98Abnormal ciliary motility (HP:0012262)1.68272745
99Poor coordination (HP:0002370)1.67905255
100Abnormal respiratory epithelium morphology (HP:0012253)1.67309755

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.59194096
2ACVR1B3.86925516
3BMPR1B3.38867137
4ADRBK23.10105671
5MST43.08492328
6TAOK32.50720194
7MAP4K22.46031222
8GRK12.41838588
9ZAK2.03545493
10TLK11.98970392
11NUAK11.80915407
12WNK31.78670634
13INSRR1.66720439
14WNK41.64206633
15DAPK21.63276851
16TXK1.61264237
17STK38L1.60157872
18CAMKK21.49528510
19STK391.48980907
20CASK1.48396845
21PINK11.46173954
22PTK2B1.45069043
23TNIK1.41888167
24OXSR11.34057039
25PAK31.30954971
26PLK21.27320625
27STK31.24384132
28TRIM281.24372057
29MAP3K121.20692952
30MAP3K41.17772246
31ADRBK11.14230326
32PRKCE1.14125625
33MAPK131.13422798
34BMPR21.10974879
35AKT31.10426494
36PNCK1.10404804
37BRSK21.08009822
38IKBKB1.07195747
39STK241.06514960
40CSF1R1.03947609
41TEC0.96739302
42MKNK20.95740213
43ERBB30.94110263
44IRAK10.89378116
45PIK3CG0.88810322
46FER0.88386989
47MYLK0.88285147
48MAPKAPK30.85784814
49TGFBR10.84961142
50EIF2AK30.84610727
51BMX0.78850269
52PHKG20.74820699
53PHKG10.74820699
54BCR0.74535172
55SYK0.73429894
56PRKCG0.73193751
57CSNK1G10.72182629
58NLK0.69266743
59VRK10.68994502
60CSNK1G30.68786110
61MAP2K70.64883802
62PRKCQ0.64151524
63CSNK1G20.63703947
64EIF2AK10.62652295
65KIT0.61122087
66CAMK2A0.58144384
67TIE10.55166194
68NTRK30.54559806
69MST1R0.52301351
70GRK70.50220841
71MAP2K60.47100724
72PRKAA20.45431965
73FLT30.45059860
74CSNK1A1L0.44979654
75EPHA30.44839650
76IGF1R0.44170372
77GRK50.43448963
78TRPM70.43250956
79MET0.43062586
80PKN10.42474509
81RIPK40.40955855
82MATK0.40561154
83PRKACG0.40175588
84PRKCA0.39925258
85MUSK0.39741716
86PIK3CA0.39602778
87DYRK20.39555286
88FGFR20.39386665
89MAP2K10.39294551
90ITK0.39290370
91PRKACA0.38930365
92CHUK0.38862194
93PRKCI0.36457725
94LYN0.35255732
95TNK20.34199702
96MKNK10.33653787
97PDK20.33353272
98BTK0.33026878
99IKBKE0.31870916
100PRKG10.31177050

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005913.07111249
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.98256849
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.58234492
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.54610172
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.32610419
6Caffeine metabolism_Homo sapiens_hsa002322.25536733
7Tryptophan metabolism_Homo sapiens_hsa003802.18744171
8Fat digestion and absorption_Homo sapiens_hsa049752.12825190
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.10881766
10Phototransduction_Homo sapiens_hsa047442.07420875
11Butanoate metabolism_Homo sapiens_hsa006502.06897065
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.05910722
13Ether lipid metabolism_Homo sapiens_hsa005652.01667118
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.00711741
15Chemical carcinogenesis_Homo sapiens_hsa052041.89599743
16Sulfur metabolism_Homo sapiens_hsa009201.87770694
17Arachidonic acid metabolism_Homo sapiens_hsa005901.79402617
18Retinol metabolism_Homo sapiens_hsa008301.79181473
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.78066032
20* Nitrogen metabolism_Homo sapiens_hsa009101.76764751
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65823476
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.65280313
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.62122687
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.58328721
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.57127465
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.52182753
27Protein export_Homo sapiens_hsa030601.48222315
28Vitamin digestion and absorption_Homo sapiens_hsa049771.45418050
29Mineral absorption_Homo sapiens_hsa049781.43506861
30ABC transporters_Homo sapiens_hsa020101.38897809
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36490579
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36135973
33Histidine metabolism_Homo sapiens_hsa003401.34829391
34Glycerolipid metabolism_Homo sapiens_hsa005611.34025427
35Peroxisome_Homo sapiens_hsa041461.31677598
36Oxidative phosphorylation_Homo sapiens_hsa001901.28531570
37Selenocompound metabolism_Homo sapiens_hsa004501.26561756
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20760788
39Asthma_Homo sapiens_hsa053101.20573074
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17780781
41Serotonergic synapse_Homo sapiens_hsa047261.16384969
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16156116
43Basal transcription factors_Homo sapiens_hsa030221.11185940
44Sphingolipid metabolism_Homo sapiens_hsa006001.10989646
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10364928
46Collecting duct acid secretion_Homo sapiens_hsa049661.05575647
47Renin-angiotensin system_Homo sapiens_hsa046141.01733903
48Type I diabetes mellitus_Homo sapiens_hsa049401.01170046
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00018982
50Starch and sucrose metabolism_Homo sapiens_hsa005000.97500541
51Circadian rhythm_Homo sapiens_hsa047100.97287306
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90140913
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87722168
54Fatty acid degradation_Homo sapiens_hsa000710.86824420
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.86662609
56Regulation of autophagy_Homo sapiens_hsa041400.86276260
57Olfactory transduction_Homo sapiens_hsa047400.81261063
58Propanoate metabolism_Homo sapiens_hsa006400.81248935
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80229408
60Graft-versus-host disease_Homo sapiens_hsa053320.78964319
61Platelet activation_Homo sapiens_hsa046110.76786870
62beta-Alanine metabolism_Homo sapiens_hsa004100.75566981
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.75561547
64Fatty acid elongation_Homo sapiens_hsa000620.74299854
65Hematopoietic cell lineage_Homo sapiens_hsa046400.72307416
66Parkinsons disease_Homo sapiens_hsa050120.70372642
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68150814
68Fatty acid biosynthesis_Homo sapiens_hsa000610.67779169
69Allograft rejection_Homo sapiens_hsa053300.67708859
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.67082908
71Primary immunodeficiency_Homo sapiens_hsa053400.65161072
72Taste transduction_Homo sapiens_hsa047420.64127901
73Nicotine addiction_Homo sapiens_hsa050330.62892581
74Insulin secretion_Homo sapiens_hsa049110.62819615
75Autoimmune thyroid disease_Homo sapiens_hsa053200.60578860
76Rheumatoid arthritis_Homo sapiens_hsa053230.60170209
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58558434
78Bile secretion_Homo sapiens_hsa049760.58268692
79Metabolic pathways_Homo sapiens_hsa011000.58133083
80PPAR signaling pathway_Homo sapiens_hsa033200.57774078
81Ovarian steroidogenesis_Homo sapiens_hsa049130.57619536
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55641723
83Morphine addiction_Homo sapiens_hsa050320.54663779
84Steroid biosynthesis_Homo sapiens_hsa001000.52907285
85Pancreatic secretion_Homo sapiens_hsa049720.51361413
86Glutathione metabolism_Homo sapiens_hsa004800.48293197
87Dorso-ventral axis formation_Homo sapiens_hsa043200.46875040
88One carbon pool by folate_Homo sapiens_hsa006700.45855568
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.45670576
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45368492
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44404203
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43223163
93Circadian entrainment_Homo sapiens_hsa047130.43086273
94Glutamatergic synapse_Homo sapiens_hsa047240.43063884
95Arginine and proline metabolism_Homo sapiens_hsa003300.42114047
96Fatty acid metabolism_Homo sapiens_hsa012120.39510235
97Salivary secretion_Homo sapiens_hsa049700.38783158
98GABAergic synapse_Homo sapiens_hsa047270.38220583
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37589484
100Alzheimers disease_Homo sapiens_hsa050100.36036981

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