CA15P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of interferon-beta biosynthetic process (GO:0045357)5.47066051
2modulation by symbiont of host defense response (GO:0052031)5.28928127
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.28928127
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.28928127
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.28928127
6modulation by symbiont of host immune response (GO:0052553)5.28928127
7positive regulation by symbiont of host defense response (GO:0052509)5.28928127
8detection of molecule of bacterial origin (GO:0032490)5.09990818
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.02355245
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.99777438
11negative regulation of cell killing (GO:0031342)4.99777438
12response to peptidoglycan (GO:0032494)4.86150980
13positive regulation of gamma-delta T cell activation (GO:0046645)4.76192641
14macrophage activation involved in immune response (GO:0002281)4.72272571
15G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.64580052
16cellular extravasation (GO:0045123)4.62931683
17positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.60534945
18detection of other organism (GO:0098543)4.43322986
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.34424571
20detection of external biotic stimulus (GO:0098581)4.29102890
21positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.17056115
22neutrophil activation involved in immune response (GO:0002283)4.08461732
23antigen processing and presentation of endogenous antigen (GO:0019883)4.05120971
24detection of bacterium (GO:0016045)3.97773493
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.87322530
26regulation of gamma-delta T cell activation (GO:0046643)3.86602552
27regulation of B cell receptor signaling pathway (GO:0050855)3.85269365
28leukocyte aggregation (GO:0070486)3.84341419
29cellular response to ATP (GO:0071318)3.79192881
30respiratory burst (GO:0045730)3.77755761
31negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.77117904
32purinergic nucleotide receptor signaling pathway (GO:0035590)3.74058405
33detection of biotic stimulus (GO:0009595)3.68125901
34leukocyte migration involved in inflammatory response (GO:0002523)3.67620936
35neutrophil activation (GO:0042119)3.66624459
36negative regulation of lymphocyte mediated immunity (GO:0002707)3.62070208
37positive regulation of interferon-alpha production (GO:0032727)3.61563550
38response to interleukin-15 (GO:0070672)3.59986374
39negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.58031904
40adenosine receptor signaling pathway (GO:0001973)3.57541927
41neutrophil mediated immunity (GO:0002446)3.57345827
42macrophage activation (GO:0042116)3.55042555
43negative regulation of interleukin-12 production (GO:0032695)3.51974512
44regulation of gamma-delta T cell differentiation (GO:0045586)3.50381345
45negative regulation of toll-like receptor signaling pathway (GO:0034122)3.49856642
46myeloid cell activation involved in immune response (GO:0002275)3.49793996
47response to muramyl dipeptide (GO:0032495)3.49378998
48germinal center formation (GO:0002467)3.48309139
49granulocyte activation (GO:0036230)3.45147910
50response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.44586174
51response to host immune response (GO:0052572)3.44586174
52positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.43561021
53negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.41515285
54production of molecular mediator involved in inflammatory response (GO:0002532)3.40141695
55negative regulation of erythrocyte differentiation (GO:0045647)3.38384899
56regulation of interferon-alpha production (GO:0032647)3.30845549
57positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.27622953
58positive regulation of toll-like receptor signaling pathway (GO:0034123)3.27399722
59G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.25863570
60negative regulation of interleukin-8 production (GO:0032717)3.21448641
61cellular response to interleukin-15 (GO:0071350)3.21291239
62microglial cell activation (GO:0001774)3.20609475
63leukocyte degranulation (GO:0043299)3.18706261
64response to host (GO:0075136)3.16200797
65response to host defenses (GO:0052200)3.16200797
66response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.16200797
67interferon-gamma production (GO:0032609)3.14060896
68negative regulation of leukocyte mediated immunity (GO:0002704)3.11509500
69B cell receptor signaling pathway (GO:0050853)3.11143153
70regulation of toll-like receptor signaling pathway (GO:0034121)3.08211415
71negative regulation of innate immune response (GO:0045824)3.07296167
72regulation of mast cell degranulation (GO:0043304)3.06601986
73GDP-mannose metabolic process (GO:0019673)3.05129480
74negative regulation of cell aging (GO:0090344)3.04318531
75purinergic receptor signaling pathway (GO:0035587)3.04211163
76positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.02054701
77negative regulation of T cell mediated immunity (GO:0002710)3.01718400
78negative regulation of glycoprotein biosynthetic process (GO:0010561)3.01089230
79myeloid leukocyte mediated immunity (GO:0002444)2.98146513
80regulation of interferon-beta production (GO:0032648)2.96311969
81positive regulation of interferon-beta production (GO:0032728)2.94204789
82positive thymic T cell selection (GO:0045059)2.93330468
83response to type I interferon (GO:0034340)2.92734044
84regulation of interleukin-6 biosynthetic process (GO:0045408)2.91801004
85response to ATP (GO:0033198)2.90778527
86regulation of myeloid leukocyte mediated immunity (GO:0002886)2.89453949
87cellular response to type I interferon (GO:0071357)2.88701917
88type I interferon signaling pathway (GO:0060337)2.88701917
89negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.87526031
90negative regulation of T-helper cell differentiation (GO:0045623)2.87526031
91negative regulation of interleukin-6 production (GO:0032715)2.83263449
92regulation of leukocyte degranulation (GO:0043300)2.82956020
93regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.82054930
94regulation of T-helper 2 cell differentiation (GO:0045628)2.81522921
95defense response to protozoan (GO:0042832)2.79722216
96regulation of mast cell activation involved in immune response (GO:0033006)2.79703052
97mannose metabolic process (GO:0006013)2.79506735
98tolerance induction (GO:0002507)2.77086421
99regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.76836133
100regulation of mast cell activation (GO:0033003)2.73815003

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human4.16019535
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.52239221
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.31438198
4VDR_24763502_ChIP-Seq_THP-1_Human2.90470332
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.86357820
6MAF_26560356_Chip-Seq_TH1_Human2.80854828
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.72555407
8MAF_26560356_Chip-Seq_TH2_Human2.70646943
9LXR_22292898_ChIP-Seq_THP-1_Human2.49503481
10MYC_22102868_ChIP-Seq_BL_Human2.48950873
11E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.48218739
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.41174072
13UTX_26944678_Chip-Seq_JUKART_Human2.37084906
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.35971632
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.35379436
16TCF7_22412390_ChIP-Seq_EML_Mouse2.24262503
17P68_20966046_ChIP-Seq_HELA_Human2.23044019
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.17337870
19KDM2B_26808549_Chip-Seq_DND41_Human2.16212201
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12147510
21BCL6_27268052_Chip-Seq_Bcells_Human2.04819521
22BCOR_27268052_Chip-Seq_Bcells_Human2.04364452
23RUNX1_22412390_ChIP-Seq_EML_Mouse1.98938383
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.96099481
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.92059852
26SPI1_23547873_ChIP-Seq_NB4_Human1.87463892
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81201333
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.80097740
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.79087423
30E2F1_20622854_ChIP-Seq_HELA_Human1.78576331
31RACK7_27058665_Chip-Seq_MCF-7_Human1.77844122
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75089983
33CTCF_27219007_Chip-Seq_ERYTHROID_Human1.72515200
34SCL_19346495_ChIP-Seq_HPC-7_Human1.69817348
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.68086591
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64822066
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.61872559
38SPI1_23127762_ChIP-Seq_K562_Human1.61352119
39SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.59359584
40PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.58366123
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.57998704
42SMC4_20622854_ChIP-Seq_HELA_Human1.56443915
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.55811164
44PU.1_20513432_ChIP-Seq_Bcells_Mouse1.54375859
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.50983823
46SA1_27219007_Chip-Seq_ERYTHROID_Human1.50207756
47MYB_26560356_Chip-Seq_TH1_Human1.49319499
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.49232417
49RUNX_20019798_ChIP-Seq_JUKART_Human1.48354391
50PHF8_20622854_ChIP-Seq_HELA_Human1.48209621
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.47199266
52CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.46547365
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46430586
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.46313440
55PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45614945
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44481708
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.41280315
58SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41011973
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.40025297
60CTCF_21964334_ChIP-Seq_BJAB-B_Human1.39746984
61MYB_26560356_Chip-Seq_TH2_Human1.34547418
62CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34526565
63CTCF_21964334_Chip-Seq_Bcells_Human1.34074834
64RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33115502
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.32984643
66MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.32736149
67RARB_24833708_ChIP-Seq_LIVER_Mouse1.31131506
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28504743
69NCOR1_26117541_ChIP-Seq_K562_Human1.27830792
70SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27715626
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25637678
72CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24668312
73FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.23347323
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23304509
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22330122
76CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20713037
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20239783
78NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19293590
79EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16767944
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15900038
81EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15621809
82RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.15580579
83KDM2B_26808549_Chip-Seq_K562_Human1.15576427
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15403915
85FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15360294
86MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14294266
87RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13830449
88CTCF_27219007_Chip-Seq_Bcells_Human1.13613668
89RARA_24833708_ChIP-Seq_LIVER_Mouse1.12793827
90CREB1_26743006_Chip-Seq_LNCaP_Human1.12670491
91ETS1_21867929_ChIP-Seq_TH2_Mouse1.11817760
92SA1_27219007_Chip-Seq_Bcells_Human1.11496551
93GATA3_27048872_Chip-Seq_THYMUS_Human1.11448200
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11363403
95FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10172168
96P300_27268052_Chip-Seq_Bcells_Human1.09482917
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08711329
98SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08110397
99GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08054801
100DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07864817

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition5.60854292
2MP0001986_abnormal_taste_sensitivity4.49127270
3MP0003724_increased_susceptibility_to4.18031572
4MP0003303_peritoneal_inflammation3.87503407
5MP0005174_abnormal_tail_pigmentation3.53663286
6MP0003436_decreased_susceptibility_to3.36207937
7MP0004381_abnormal_hair_follicle3.07603183
8MP0001835_abnormal_antigen_presentation2.44247134
9MP0005171_absent_coat_pigmentation2.41849040
10MP0002419_abnormal_innate_immunity2.30686657
11MP0005423_abnormal_somatic_nervous2.27488392
12MP0003172_abnormal_lysosome_physiology2.19606792
13MP0005025_abnormal_response_to2.16848025
14MP0001800_abnormal_humoral_immune2.12905831
15MP0002723_abnormal_immune_serum2.01018001
16MP0005409_darkened_coat_color1.98457025
17MP0000015_abnormal_ear_pigmentation1.93474762
18MP0005000_abnormal_immune_tolerance1.91704162
19MP0002132_abnormal_respiratory_system1.88778657
20MP0003763_abnormal_thymus_physiology1.88383052
21MP0002420_abnormal_adaptive_immunity1.88368616
22MP0001790_abnormal_immune_system1.88216513
23MP0005387_immune_system_phenotype1.88216513
24MP0001819_abnormal_immune_cell1.86858390
25MP0000685_abnormal_immune_system1.86013563
26MP0002452_abnormal_antigen_presenting1.79632427
27MP0009278_abnormal_bone_marrow1.77873791
28MP0005671_abnormal_response_to1.76902326
29MP0002277_abnormal_respiratory_mucosa1.73046706
30MP0009785_altered_susceptibility_to1.69086286
31MP0003136_yellow_coat_color1.63685291
32MP0006082_CNS_inflammation1.62133217
33MP0003878_abnormal_ear_physiology1.60359753
34MP0005377_hearing/vestibular/ear_phenot1.60359753
35MP0002405_respiratory_system_inflammati1.58025308
36MP0005083_abnormal_biliary_tract1.53388258
37MP0008260_abnormal_autophagy1.52895162
38MP0002398_abnormal_bone_marrow1.49955117
39MP0000716_abnormal_immune_system1.44913929
40MP0003191_abnormal_cellular_cholesterol1.44804113
41MP0010155_abnormal_intestine_physiology1.42713570
42MP0001968_abnormal_touch/_nociception1.42516616
43MP0004130_abnormal_muscle_cell1.40209321
44MP0001533_abnormal_skeleton_physiology1.38522888
45MP0005058_abnormal_lysosome_morphology1.35790123
46MP0001845_abnormal_inflammatory_respons1.33631190
47MP0002148_abnormal_hypersensitivity_rea1.31226500
48MP0002396_abnormal_hematopoietic_system1.29901231
49MP0004947_skin_inflammation1.29829261
50MP0002722_abnormal_immune_system1.21420828
51MP0000703_abnormal_thymus_morphology1.17934107
52MP0002429_abnormal_blood_cell1.17460978
53MP0003300_gastrointestinal_ulcer1.17205645
54MP0001756_abnormal_urination1.15580187
55MP0000689_abnormal_spleen_morphology1.15475662
56MP0009333_abnormal_splenocyte_physiolog1.13977901
57MP0003453_abnormal_keratinocyte_physiol1.12676316
58MP0005464_abnormal_platelet_physiology1.12166235
59MP0008469_abnormal_protein_level1.09337729
60MP0000750_abnormal_muscle_regeneration1.08668472
61MP0003828_pulmonary_edema1.04739719
62MP0000465_gastrointestinal_hemorrhage1.04322535
63MP0002638_abnormal_pupillary_reflex1.03869117
64MP0009764_decreased_sensitivity_to1.03751204
65MP0001873_stomach_inflammation1.02573242
66MP0005076_abnormal_cell_differentiation0.99050474
67MP0002928_abnormal_bile_duct0.98846226
68MP0000470_abnormal_stomach_morphology0.96719558
69MP0003806_abnormal_nucleotide_metabolis0.92844368
70MP0001188_hyperpigmentation0.89719980
71MP0005397_hematopoietic_system_phenotyp0.89307048
72MP0001545_abnormal_hematopoietic_system0.89307048
73MP0003866_abnormal_defecation0.86469177
74MP0001661_extended_life_span0.85428449
75MP0004883_abnormal_blood_vessel0.79820051
76MP0005310_abnormal_salivary_gland0.78938655
77MP0003183_abnormal_peptide_metabolism0.77484717
78MP0000858_altered_metastatic_potential0.75484071
79MP0002736_abnormal_nociception_after0.75411447
80MP0001851_eye_inflammation0.73624146
81MP0001765_abnormal_ion_homeostasis0.72364546
82MP0003448_altered_tumor_morphology0.71527026
83MP0003075_altered_response_to0.71127938
84MP0008875_abnormal_xenobiotic_pharmacok0.70984626
85MP0005584_abnormal_enzyme/coenzyme_acti0.70311380
86MP0002998_abnormal_bone_remodeling0.69526568
87MP0003656_abnormal_erythrocyte_physiolo0.68671614
88MP0003045_fibrosis0.67844853
89MP0002735_abnormal_chemical_nociception0.67800496
90MP0001663_abnormal_digestive_system0.67315607
91MP0000538_abnormal_urinary_bladder0.64793548
92MP0002933_joint_inflammation0.64476493
93MP0002166_altered_tumor_susceptibility0.62120819
94MP0009931_abnormal_skin_appearance0.61001996
95MP0002693_abnormal_pancreas_physiology0.60973968
96MP0001919_abnormal_reproductive_system0.60669907
97MP0000751_myopathy0.60624113
98MP0005164_abnormal_response_to0.58910198
99MP0002019_abnormal_tumor_incidence0.57288250
100MP0008874_decreased_physiological_sensi0.57223059

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.10689542
2Myositis (HP:0100614)4.40759851
3Recurrent abscess formation (HP:0002722)4.35177089
4Recurrent bacterial skin infections (HP:0005406)4.30258630
5Orchitis (HP:0100796)4.27423475
6Optic neuritis (HP:0100653)4.02442811
7Retrobulbar optic neuritis (HP:0100654)4.02442811
8Rib fusion (HP:0000902)3.94868201
9Gastrointestinal infarctions (HP:0005244)3.91074105
10Attenuation of retinal blood vessels (HP:0007843)3.77491387
11Stomatitis (HP:0010280)3.74087098
12Elevated erythrocyte sedimentation rate (HP:0003565)3.71893160
13Thin bony cortex (HP:0002753)3.71198877
14Abnormality of macrophages (HP:0004311)3.67820688
15Testicular atrophy (HP:0000029)3.59372590
16Facial diplegia (HP:0001349)3.49083886
17Recurrent fungal infections (HP:0002841)3.45167043
18Poikiloderma (HP:0001029)3.43370595
19Hemorrhage of the eye (HP:0011885)3.37290235
20Recurrent cutaneous fungal infections (HP:0011370)3.26648653
21Chronic mucocutaneous candidiasis (HP:0002728)3.26648653
22Annular pancreas (HP:0001734)3.25907835
23Recurrent gram-negative bacterial infections (HP:0005420)3.22982275
24Mediastinal lymphadenopathy (HP:0100721)3.22928536
25Hypochromic anemia (HP:0001931)3.21593584
26Intestinal fistula (HP:0100819)3.21201438
27Joint hemorrhage (HP:0005261)3.10128854
28Obstructive lung disease (HP:0006536)3.05687676
29Chronic obstructive pulmonary disease (HP:0006510)3.05687676
30Recurrent skin infections (HP:0001581)3.03454094
31Rectal fistula (HP:0100590)3.01154767
32Rectovaginal fistula (HP:0000143)3.01154767
33Anorexia (HP:0002039)2.97959811
34Episodic fever (HP:0001954)2.94853834
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.91929916
36Dyschromatopsia (HP:0007641)2.91290222
37Vaginal fistula (HP:0004320)2.85888687
38Pustule (HP:0200039)2.85469229
39Meningitis (HP:0001287)2.84047555
40Increased IgE level (HP:0003212)2.81238174
41Cheilitis (HP:0100825)2.78230091
42Keratoconjunctivitis sicca (HP:0001097)2.73438328
43Facial hemangioma (HP:0000329)2.72576147
44Keratoconjunctivitis (HP:0001096)2.68308060
45Ulnar bowing (HP:0003031)2.66604714
46Choroideremia (HP:0001139)2.66134335
47Basal cell carcinoma (HP:0002671)2.62716087
48Bony spicule pigmentary retinopathy (HP:0007737)2.62558503
49Prolonged bleeding time (HP:0003010)2.59366188
50Encephalitis (HP:0002383)2.58908650
51Akinesia (HP:0002304)2.56441143
52Hypochromic microcytic anemia (HP:0004840)2.48021561
53Widely patent fontanelles and sutures (HP:0004492)2.43964066
54Arterial thrombosis (HP:0004420)2.43610787
55Gingivitis (HP:0000230)2.42406929
56Decreased electroretinogram (ERG) amplitude (HP:0000654)2.42024776
57Chest pain (HP:0100749)2.40819561
58Abnormality of the costochondral junction (HP:0000919)2.40246560
59Decreased central vision (HP:0007663)2.38856467
60Vasculitis (HP:0002633)2.38329382
61Urticaria (HP:0001025)2.31984775
62Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.31414657
63Popliteal pterygium (HP:0009756)2.29386481
64Short chin (HP:0000331)2.26363695
65Epistaxis (HP:0000421)2.24625204
66Congenital stationary night blindness (HP:0007642)2.22909506
67Hemoptysis (HP:0002105)2.20890164
68Turricephaly (HP:0000262)2.20395092
69Petechiae (HP:0000967)2.18937166
70Squamous cell carcinoma (HP:0002860)2.17186259
71Abnormality of the common coagulation pathway (HP:0010990)2.15442714
72Chorioretinal atrophy (HP:0000533)2.09387325
73Prolonged partial thromboplastin time (HP:0003645)2.08411951
74Fetal akinesia sequence (HP:0001989)2.07932017
75Abnormality of the intrinsic pathway (HP:0010989)2.06970772
76Inflammation of the large intestine (HP:0002037)2.06513305
77Spontaneous hematomas (HP:0007420)2.06351783
78Cellulitis (HP:0100658)2.04433748
79Delayed epiphyseal ossification (HP:0002663)2.03731922
80Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.02834021
81Enlarged epiphyses (HP:0010580)2.00833031
82Anteriorly placed anus (HP:0001545)1.99842288
83Joint stiffness (HP:0001387)1.98418126
84Gastrointestinal inflammation (HP:0004386)1.95921928
85Gingival bleeding (HP:0000225)1.95229732
86Abnormality of the endocardium (HP:0004306)1.94646241
87Flat occiput (HP:0005469)1.92389258
88Hypophosphatemic rickets (HP:0004912)1.90261274
89Neonatal respiratory distress (HP:0002643)1.89853182
90Aplasia of the musculature (HP:0100854)1.89608720
91Capillary hemangiomas (HP:0005306)1.88627715
92Acute hepatic failure (HP:0006554)1.88594267
93Respiratory difficulties (HP:0002880)1.88125576
94Abnormality of the fingertips (HP:0001211)1.86361932
95Granulocytopenia (HP:0001913)1.86010675
96Abnormality of mucopolysaccharide metabolism (HP:0011020)1.81295423
97Abnormality of polysaccharide metabolism (HP:0011012)1.81295423
98Abnormality of glycosaminoglycan metabolism (HP:0004371)1.81295423
99T lymphocytopenia (HP:0005403)1.81035107
100Premature graying of hair (HP:0002216)1.78961219

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.88819858
2MAP4K13.32490581
3MAP2K33.15231342
4IRAK43.14465925
5MAPK153.10330806
6RIPK43.08732131
7ERN12.85851098
8GRK62.80495857
9EPHB12.42906353
10TNK22.30195120
11CSK2.29935528
12IRAK22.25372753
13TYK22.19155181
14ZAP702.14387078
15TRIB31.96124998
16TAOK11.93540510
17MAP3K21.82980600
18PRPF4B1.66218077
19MAP3K111.63337363
20BTK1.62332832
21MAP3K31.59690428
22MARK21.57948180
23FES1.57202929
24KSR21.48620986
25HCK1.47455029
26MAP3K11.42499559
27SIK21.40081527
28TXK1.39298032
29IKBKE1.35253558
30JAK21.34454897
31SIK31.23600072
32JAK31.21094558
33IRAK11.19158166
34LYN1.18528386
35TBK11.17443820
36PRKD21.16668728
37TESK21.13328580
38SIK11.12106678
39SYK1.08683646
40PDPK11.03060868
41YES10.95328315
42JAK10.95016877
43PTK60.93396831
44MAP2K60.86323554
45DYRK1B0.84956560
46SGK30.83866858
47WNK10.83651133
48HIPK20.83299444
49STK110.82826924
50LCK0.81816699
51SMG10.81158122
52MAP3K140.78355074
53MUSK0.78234051
54MAPK120.77379474
55MAP2K40.76762624
56TLK10.72537245
57PDK10.72154741
58TAOK30.70727375
59WNK40.68357843
60FGR0.66711427
61LRRK20.66619651
62ITK0.64910210
63FRK0.62742923
64STK380.62552134
65PRKAA20.61098039
66FGFR30.60689568
67RPS6KL10.60565747
68RPS6KC10.60565747
69MARK30.59518744
70MAP3K70.58037061
71PRKD10.57468361
72SGK20.57313064
73IKBKB0.57302845
74CDK190.57235637
75RPS6KA60.57038402
76RAF10.54296812
77FGFR40.53726789
78PKN20.53724900
79CAMKK10.53634157
80CDC42BPA0.53377814
81PRKCH0.52364336
82MAP3K100.51975641
83TAOK20.51342356
84OXSR10.51191350
85EPHA30.49750695
86CDK120.48841922
87CDK40.48731367
88RPS6KA20.46915104
89RET0.46730917
90DAPK20.46029369
91SGK4940.44469151
92SGK2230.44469151
93CSF1R0.44461278
94FYN0.42710335
95STK100.40941522
96NLK0.40719707
97PRKCZ0.36425571
98PIK3CG0.36291280
99MAPK70.35933409
100MAPK110.35766943

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.51887563
2Osteoclast differentiation_Homo sapiens_hsa043802.67795415
3Leishmaniasis_Homo sapiens_hsa051402.24015502
4B cell receptor signaling pathway_Homo sapiens_hsa046622.17028267
5Acute myeloid leukemia_Homo sapiens_hsa052212.12153697
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.12062139
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.99783185
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.91693048
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.88192396
10Tuberculosis_Homo sapiens_hsa051521.86641998
11Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.82370528
12Staphylococcus aureus infection_Homo sapiens_hsa051501.81534220
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.81196365
14Jak-STAT signaling pathway_Homo sapiens_hsa046301.65933595
15Sulfur relay system_Homo sapiens_hsa041221.65375212
16Carbohydrate digestion and absorption_Homo sapiens_hsa049731.62136070
17Non-small cell lung cancer_Homo sapiens_hsa052231.60686151
18Fructose and mannose metabolism_Homo sapiens_hsa000511.57911986
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.56711217
20Malaria_Homo sapiens_hsa051441.56701445
21Measles_Homo sapiens_hsa051621.56490003
22T cell receptor signaling pathway_Homo sapiens_hsa046601.54152939
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.53891588
24Chemokine signaling pathway_Homo sapiens_hsa040621.49069101
25Hepatitis C_Homo sapiens_hsa051601.46273470
26VEGF signaling pathway_Homo sapiens_hsa043701.40135642
27Primary immunodeficiency_Homo sapiens_hsa053401.40130702
28Influenza A_Homo sapiens_hsa051641.36215796
29Endometrial cancer_Homo sapiens_hsa052131.35551208
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.33771037
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27094940
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26771858
33TNF signaling pathway_Homo sapiens_hsa046681.25732949
34Hepatitis B_Homo sapiens_hsa051611.23557612
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.23115341
36mTOR signaling pathway_Homo sapiens_hsa041501.22693353
37Renal cell carcinoma_Homo sapiens_hsa052111.22167517
38Toxoplasmosis_Homo sapiens_hsa051451.20381614
39Neurotrophin signaling pathway_Homo sapiens_hsa047221.19616471
40Hematopoietic cell lineage_Homo sapiens_hsa046401.19052588
41Insulin resistance_Homo sapiens_hsa049311.16045985
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15477989
43Prolactin signaling pathway_Homo sapiens_hsa049171.15218085
44Legionellosis_Homo sapiens_hsa051341.14097249
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10240038
46Chronic myeloid leukemia_Homo sapiens_hsa052201.09392648
47Inositol phosphate metabolism_Homo sapiens_hsa005621.07561209
48Other glycan degradation_Homo sapiens_hsa005111.04802554
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.03558766
50FoxO signaling pathway_Homo sapiens_hsa040681.00453934
51Notch signaling pathway_Homo sapiens_hsa043300.99752873
52Endocytosis_Homo sapiens_hsa041440.95596693
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92946761
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.92531969
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90055377
56Pancreatic cancer_Homo sapiens_hsa052120.89618055
57Apoptosis_Homo sapiens_hsa042100.87988468
58Graft-versus-host disease_Homo sapiens_hsa053320.87899749
59Herpes simplex infection_Homo sapiens_hsa051680.86114898
60African trypanosomiasis_Homo sapiens_hsa051430.84578570
61Type II diabetes mellitus_Homo sapiens_hsa049300.83484588
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81981509
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78931120
64Dorso-ventral axis formation_Homo sapiens_hsa043200.76743941
65Lysosome_Homo sapiens_hsa041420.75922291
66Platelet activation_Homo sapiens_hsa046110.75470489
67Insulin signaling pathway_Homo sapiens_hsa049100.74812725
68Allograft rejection_Homo sapiens_hsa053300.71278500
69Colorectal cancer_Homo sapiens_hsa052100.70854766
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70844418
71Autoimmune thyroid disease_Homo sapiens_hsa053200.70675643
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.70197744
73Prostate cancer_Homo sapiens_hsa052150.69849937
74Phagosome_Homo sapiens_hsa041450.68902330
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.67641237
76Choline metabolism in cancer_Homo sapiens_hsa052310.65718094
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64728440
78Type I diabetes mellitus_Homo sapiens_hsa049400.63207411
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62583981
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62502462
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62425050
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61845789
83ErbB signaling pathway_Homo sapiens_hsa040120.61761634
84Pertussis_Homo sapiens_hsa051330.61372391
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58936977
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57577623
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57444523
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56787642
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.56360073
90MAPK signaling pathway_Homo sapiens_hsa040100.54005418
91GnRH signaling pathway_Homo sapiens_hsa049120.53945905
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53667566
93Regulation of autophagy_Homo sapiens_hsa041400.51003433
94Salmonella infection_Homo sapiens_hsa051320.50055310
95Glioma_Homo sapiens_hsa052140.49923192
96Viral carcinogenesis_Homo sapiens_hsa052030.49187457
97Circadian rhythm_Homo sapiens_hsa047100.48649016
98Sphingolipid metabolism_Homo sapiens_hsa006000.47990691
99Epstein-Barr virus infection_Homo sapiens_hsa051690.47694307
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47359764

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