ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	actin filament-based movement (GO:0030048)	8.16845302
2	regulation of relaxation of muscle (GO:1901077)	8.08211572
3	myofibril assembly (GO:0030239)	7.67236000
4	striated muscle contraction (GO:0006941)	7.65815134
5	sarcomere organization (GO:0045214)	7.15366970
6	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	7.08792218
7	response to muscle activity (GO:0014850)	7.07769362
8	creatine metabolic process (GO:0006600)	7.00962702
9	skeletal muscle adaptation (GO:0043501)	6.85560350
10	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	6.81685985
11	skeletal muscle fiber development (GO:0048741)	6.80790904
12	response to inactivity (GO:0014854)	6.52887996
13	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	6.28453902
14	myotube cell development (GO:0014904)	6.19151511
15	plasma membrane repair (GO:0001778)	5.95478545
16	muscle contraction (GO:0006936)	5.86239291
17	cardiac myofibril assembly (GO:0055003)	5.71769102
18	actomyosin structure organization (GO:0031032)	5.51282833
19	glycogen catabolic process (GO:0005980)	5.43491974
20	cardiac muscle contraction (GO:0060048)	5.30393110
21	muscle system process (GO:0003012)	5.26304134
22	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	5.16352465
23	glucan catabolic process (GO:0009251)	5.11402644
24	glycogen biosynthetic process (GO:0005978)	5.06776517
25	glucan biosynthetic process (GO:0009250)	5.06776517
26	muscle fiber development (GO:0048747)	5.03741520
27	regulation of cell communication by electrical coupling (GO:0010649)	5.02975657
28	muscle cell fate commitment (GO:0042693)	5.02944248
29	skeletal muscle tissue development (GO:0007519)	5.00845303
30	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	4.95579691
31	striated muscle adaptation (GO:0014888)	4.89502116
32	striated muscle hypertrophy (GO:0014897)	4.82938624
33	cellular polysaccharide catabolic process (GO:0044247)	4.79510719
34	skeletal muscle tissue regeneration (GO:0043403)	4.73946341
35	regulation of actin filament-based movement (GO:1903115)	4.69117251
36	NADH metabolic process (GO:0006734)	4.68409585
37	negative regulation of potassium ion transmembrane transport (GO:1901380)	4.51720930
38	cardiac muscle hypertrophy (GO:0003300)	4.51440723
39	muscle cell cellular homeostasis (GO:0046716)	4.45725754
40	muscle hypertrophy (GO:0014896)	4.32641500
41	polysaccharide catabolic process (GO:0000272)	4.32128699
42	positive regulation of myotube differentiation (GO:0010831)	4.24957552
43	striated muscle atrophy (GO:0014891)	4.08033714
44	muscle structure development (GO:0061061)	4.06496290
45	muscle organ development (GO:0007517)	4.06095706
46	glycogen metabolic process (GO:0005977)	4.02656621
47	fructose metabolic process (GO:0006000)	3.97637461
48	cellular glucan metabolic process (GO:0006073)	3.94842256
49	glucan metabolic process (GO:0044042)	3.94842256
50	muscle adaptation (GO:0043500)	3.94675143
51	otic vesicle formation (GO:0030916)	3.92022498
52	striated muscle cell development (GO:0055002)	3.91794549
53	muscle tissue morphogenesis (GO:0060415)	3.89176902
54	regulation of striated muscle contraction (GO:0006942)	3.86789942
55	myoblast fusion (GO:0007520)	3.85085892
56	2-oxoglutarate metabolic process (GO:0006103)	3.84161321
57	muscle organ morphogenesis (GO:0048644)	3.79991785
58	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	3.78565554
59	response to activity (GO:0014823)	3.75048999
60	gluconeogenesis (GO:0006094)	3.73771753
61	muscle atrophy (GO:0014889)	3.66682881
62	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	3.66617296
63	cardiac muscle tissue morphogenesis (GO:0055008)	3.66457833
64	positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	3.63954576
65	regulation of myoblast differentiation (GO:0045661)	3.63661175
66	adult heart development (GO:0007512)	3.62729954
67	regulation of calcium ion transmembrane transport (GO:1903169)	3.62459975
68	regulation of calcium ion transmembrane transporter activity (GO:1901019)	3.62459975
69	regulation of skeletal muscle cell differentiation (GO:2001014)	3.61970878
70	myotube differentiation (GO:0014902)	3.55316345
71	negative regulation of calcium ion transmembrane transport (GO:1903170)	3.54860532
72	negative regulation of calcium ion transmembrane transporter activity (GO:1901020)	3.54860532
73	cardiac muscle cell development (GO:0055013)	3.53984687
74	carnitine shuttle (GO:0006853)	3.52236545
75	tricarboxylic acid cycle (GO:0006099)	3.50109073
76	negative regulation of muscle contraction (GO:0045932)	3.48757921
77	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	3.47861497
78	positive regulation of myoblast differentiation (GO:0045663)	3.41938466
79	muscle cell development (GO:0055001)	3.41371481
80	striated muscle tissue development (GO:0014706)	3.39457081
81	syncytium formation by plasma membrane fusion (GO:0000768)	3.36951355
82	hexose biosynthetic process (GO:0019319)	3.34355605
83	IMP metabolic process (GO:0046040)	3.34342620
84	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	3.31134554
85	cardiac cell development (GO:0055006)	3.28093023
86	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	3.26899419
87	cardiac muscle adaptation (GO:0014887)	3.22359679
88	cardiac muscle hypertrophy in response to stress (GO:0014898)	3.22359679
89	muscle hypertrophy in response to stress (GO:0003299)	3.22359679
90	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.16671007
91	regulation of myotube differentiation (GO:0010830)	3.14409954
92	regulation of muscle system process (GO:0090257)	3.13911790
93	relaxation of muscle (GO:0090075)	3.13531012
94	regulation of the force of heart contraction (GO:0002026)	3.11890410
95	actin-myosin filament sliding (GO:0033275)	13.3084503
96	muscle filament sliding (GO:0030049)	13.3084503
97	sarcoplasmic reticulum calcium ion transport (GO:0070296)	11.3775540
98	skeletal muscle contraction (GO:0003009)	10.9827108
99	actin-mediated cell contraction (GO:0070252)	10.9510448
100	regulation of skeletal muscle contraction (GO:0014819)	10.2306527

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	7.73234220
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.79467704
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.06191847
4	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.50014753
5	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.28755899
6	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.03156099
7	TBX20_22080862_ChIP-Seq_HEART_Mouse	2.91787650
8	TBX20_22328084_ChIP-Seq_HEART_Mouse	2.91787650
9	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.66425750
10	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	2.56294977
11	EP300_21415370_ChIP-Seq_HL-1_Mouse	2.44177071
12	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.41369034
13	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.33903676
14	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	2.22420124
15	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	2.18796364
16	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	2.16661850
17	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.06147171
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.85706534
19	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.77359769
20	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.66137042
21	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	1.65859819
22	GATA4_21415370_ChIP-Seq_HL-1_Mouse	1.62027349
23	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.58916675
24	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.51533460
25	CTCF_27219007_Chip-Seq_Bcells_Human	1.49932351
26	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.47508838
27	ZNF263_19887448_ChIP-Seq_K562_Human	1.47218116
28	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.43975578
29	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.40443015
30	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.35842918
31	AR_21572438_ChIP-Seq_LNCaP_Human	1.33403387
32	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.33173667
33	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.28296532
34	DROSHA_22980978_ChIP-Seq_HELA_Human	1.24530777
35	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.24041400
36	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.20455629
37	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.15756185
38	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.11719128
39	SMC3_22415368_ChIP-Seq_MEFs_Mouse	1.10246107
40	* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.10108104
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.09889965
42	IGF1R_20145208_ChIP-Seq_DFB_Human	1.08108656
43	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.06529857
44	CLOCK_20551151_ChIP-Seq_293T_Human	1.05467032
45	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.05402451
46	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.03508951
47	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.02511432
48	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.02126354
49	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.01525229
50	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.01093908
51	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.00648672
52	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.99095969
53	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.97854437
54	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.97739156
55	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.97286252
56	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.97243548
57	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.96883149
58	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.96268653
59	SA1_27219007_Chip-Seq_Bcells_Human	0.95912363
60	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.95354585
61	RXR_22158963_ChIP-Seq_LIVER_Mouse	0.95030878
62	SPI1_20517297_ChIP-Seq_HL60_Human	0.94474617
63	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.94451482
64	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.94295975
65	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.94257264
66	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.91087297
67	EGR1_19032775_ChIP-ChIP_M12_Human	0.90784084
68	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.90500746
69	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.89123826
70	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.89123826
71	LXR_22158963_ChIP-Seq_LIVER_Mouse	0.89057845
72	PRDM14_21183938_ChIP-Seq_MESCs_Mouse	0.89026443
73	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.87685393
74	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.87206222
75	GBX2_23144817_ChIP-Seq_PC3_Human	0.85746635
76	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.85281410
77	CTCF_21964334_Chip-Seq_Bcells_Human	0.84913428
78	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.84446412
79	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.84062140
80	OCT4_20526341_ChIP-Seq_ESCs_Human	0.83968351
81	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.83930699
82	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.83178660
83	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.81703850
84	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.81020512
85	HTT_18923047_ChIP-ChIP_STHdh_Human	0.78927066
86	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.78113785
87	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.77174100
88	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.76802189
89	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.76201118
90	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.74984187
91	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.74153127
92	KDM2B_26808549_Chip-Seq_DND41_Human	0.74027897
93	SMC1_22415368_ChIP-Seq_MEFs_Mouse	0.73964628
94	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.73147311
95	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.72775439
96	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.72490385
97	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.71933106
98	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.71897574
99	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.71897574
100	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.71528484

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004145_abnormal_muscle_electrophysio	6.93720428
2	MP0003646_muscle_fatigue	6.78133040
3	MP0000751_myopathy	6.08898706
4	MP0000749_muscle_degeneration	5.98108849
5	MP0004036_abnormal_muscle_relaxation	4.26114659
6	MP0002106_abnormal_muscle_physiology	3.81863939
7	MP0000747_muscle_weakness	3.64045394
8	MP0004087_abnormal_muscle_fiber	3.58734089
9	MP0000759_abnormal_skeletal_muscle	3.56709175
10	MP0005451_abnormal_body_composition	3.33818598
11	MP0005369_muscle_phenotype	3.26155548
12	MP0002332_abnormal_exercise_endurance	3.10643971
13	MP0002269_muscular_atrophy	3.06085478
14	MP0004084_abnormal_cardiac_muscle	3.03899074
15	MP0000750_abnormal_muscle_regeneration	3.00740515
16	MP0005620_abnormal_muscle_contractility	2.87237133
17	MP0004130_abnormal_muscle_cell	2.85752861
18	MP0004233_abnormal_muscle_weight	2.83806807
19	MP0005330_cardiomyopathy	2.63908984
20	MP0000733_abnormal_muscle_development	2.33322315
21	MP0002108_abnormal_muscle_morphology	2.12719863
22	MP0002972_abnormal_cardiac_muscle	2.08970846
23	MP0002837_dystrophic_cardiac_calcinosis	1.98979797
24	MP0006036_abnormal_mitochondrial_physio	1.87083737
25	MP0004215_abnormal_myocardial_fiber	1.75466331
26	MP0000013_abnormal_adipose_tissue	1.73411098
27	MP0004484_altered_response_of	1.71654447
28	MP0004270_analgesia	1.63148044
29	MP0010630_abnormal_cardiac_muscle	1.58213164
30	MP0001661_extended_life_span	1.46877420
31	MP0004510_myositis	1.43273282
32	MP0005266_abnormal_metabolism	1.42908291
33	MP0002127_abnormal_cardiovascular_syste	1.40929119
34	MP0006138_congestive_heart_failure	1.28543373
35	MP0005385_cardiovascular_system_phenoty	1.28103708
36	MP0001544_abnormal_cardiovascular_syste	1.28103708
37	MP0003950_abnormal_plasma_membrane	1.19718890
38	MP0002971_abnormal_brown_adipose	1.14145016
39	MP0003221_abnormal_cardiomyocyte_apopto	1.11191688
40	MP0004185_abnormal_adipocyte_glucose	0.98436569
41	MP0002822_catalepsy	0.92526387
42	MP0005375_adipose_tissue_phenotype	0.90186045
43	MP0000003_abnormal_adipose_tissue	0.89864946
44	MP0003137_abnormal_impulse_conducting	0.86313562
45	MP0005666_abnormal_adipose_tissue	0.85656846
46	MP0008775_abnormal_heart_ventricle	0.79987777
47	MP0010030_abnormal_orbit_morphology	0.76258308
48	MP0003879_abnormal_hair_cell	0.75711135
49	MP0005670_abnormal_white_adipose	0.71315589
50	MP0003045_fibrosis	0.71051641
51	MP0009780_abnormal_chondrocyte_physiolo	0.70231413
52	MP0004085_abnormal_heartbeat	0.69655485
53	MP0004147_increased_porphyrin_level	0.67456649
54	MP0003828_pulmonary_edema	0.66049966
55	MP0001299_abnormal_eye_distance/	0.63578868
56	MP0004043_abnormal_pH_regulation	0.61529994
57	MP0000266_abnormal_heart_morphology	0.61505695
58	MP0000372_irregular_coat_pigmentation	0.59156206
59	MP0004134_abnormal_chest_morphology	0.56597315
60	MP0005377_hearing/vestibular/ear_phenot	0.56187532
61	MP0003878_abnormal_ear_physiology	0.56187532
62	MP0003656_abnormal_erythrocyte_physiolo	0.53705490
63	MP0009250_abnormal_appendicular_skeleto	0.49233516
64	MP0002078_abnormal_glucose_homeostasis	0.47166350
65	MP0009672_abnormal_birth_weight	0.46504858
66	MP0000762_abnormal_tongue_morphology	0.44741820
67	MP0001346_abnormal_lacrimal_gland	0.43554572
68	MP0002128_abnormal_blood_circulation	0.41024350
69	MP0005083_abnormal_biliary_tract	0.40863862
70	MP0004142_abnormal_muscle_tone	0.39983730
71	MP0008569_lethality_at_weaning	0.39307030
72	MP0002114_abnormal_axial_skeleton	0.38605055
73	MP0005584_abnormal_enzyme/coenzyme_acti	0.37901268
74	MP0005376_homeostasis/metabolism_phenot	0.35877923
75	MP0005248_abnormal_Harderian_gland	0.35265372
76	MP0005167_abnormal_blood-brain_barrier	0.33908319
77	MP0005535_abnormal_body_temperature	0.33642025
78	MP0000230_abnormal_systemic_arterial	0.32799571
79	MP0003948_abnormal_gas_homeostasis	0.32401773
80	MP0005166_decreased_susceptibility_to	0.32397914
81	MP0005452_abnormal_adipose_tissue	0.32013442
82	MP0002638_abnormal_pupillary_reflex	0.30562736
83	MP0002734_abnormal_mechanical_nocicepti	0.30360203
84	MP0002102_abnormal_ear_morphology	0.29791130
85	MP0002896_abnormal_bone_mineralization	0.29059949
86	MP0005332_abnormal_amino_acid	0.28306464
87	MP0005334_abnormal_fat_pad	0.24776319
88	MP0001943_abnormal_respiration	0.23970744
89	MP0005319_abnormal_enzyme/_coenzyme	0.23116369
90	MP0005165_increased_susceptibility_to	0.22935494
91	MP0006276_abnormal_autonomic_nervous	0.21806953
92	MP0002249_abnormal_larynx_morphology	0.21187900
93	MP0003941_abnormal_skin_development	0.21153868
94	MP0005187_abnormal_penis_morphology	0.18984422
95	MP0000579_abnormal_nail_morphology	0.18675517
96	MP0002066_abnormal_motor_capabilities/c	0.18670144
97	MP0006035_abnormal_mitochondrial_morpho	0.18429003
98	MP0005257_abnormal_intraocular_pressure	0.18365340
99	MP0004197_abnormal_fetal_growth/weight/	0.17778140
100	MP0002277_abnormal_respiratory_mucosa	0.17601812

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type 1 muscle fiber predominance (HP:0003803)	8.36185033
2	Exercise-induced myalgia (HP:0003738)	8.02190310
3	Exercise-induced muscle cramps (HP:0003710)	7.34711380
4	Distal arthrogryposis (HP:0005684)	7.14830893
5	Muscle hypertrophy of the lower extremities (HP:0008968)	6.06132149
6	Myopathic facies (HP:0002058)	5.83868877
7	Round ear (HP:0100830)	5.56327178
8	Calf muscle hypertrophy (HP:0008981)	5.50530234
9	Ulnar deviation of the wrist (HP:0003049)	5.26337938
10	EMG: myopathic abnormalities (HP:0003458)	5.22228787
11	Muscle fiber splitting (HP:0003555)	4.89966588
12	Rhabdomyolysis (HP:0003201)	4.68468208
13	Calcaneovalgus deformity (HP:0001848)	4.64628097
14	Myoglobinuria (HP:0002913)	4.59699984
15	Centrally nucleated skeletal muscle fibers (HP:0003687)	4.56741570
16	Hyporeflexia of lower limbs (HP:0002600)	4.55004838
17	Abnormality of the calf musculature (HP:0001430)	4.53441156
18	Neck muscle weakness (HP:0000467)	4.47275203
19	Absent phalangeal crease (HP:0006109)	4.26323036
20	Rimmed vacuoles (HP:0003805)	4.24002596
21	Abnormality of skeletal muscle fiber size (HP:0012084)	4.18497760
22	Deformed tarsal bones (HP:0008119)	4.13669938
23	Difficulty running (HP:0009046)	3.95631285
24	Subaortic stenosis (HP:0001682)	3.92232696
25	Abnormality of the left ventricular outflow tract (HP:0011103)	3.92232696
26	Increased connective tissue (HP:0009025)	3.67045552
27	Muscle stiffness (HP:0003552)	3.61620434
28	Malignant hyperthermia (HP:0002047)	3.55229558
29	Abnormal finger flexion creases (HP:0006143)	3.54667893
30	Increased variability in muscle fiber diameter (HP:0003557)	3.48176442
31	Frequent falls (HP:0002359)	3.40710510
32	Distal lower limb muscle weakness (HP:0009053)	3.32032653
33	Myotonia (HP:0002486)	3.23276924
34	Fetal akinesia sequence (HP:0001989)	3.19708002
35	Asymmetric septal hypertrophy (HP:0001670)	3.16941532
36	Areflexia of lower limbs (HP:0002522)	3.12182665
37	Sudden death (HP:0001699)	3.08548864
38	EMG: neuropathic changes (HP:0003445)	2.91888635
39	Generalized muscle weakness (HP:0003324)	2.90588428
40	Mildly elevated creatine phosphokinase (HP:0008180)	2.82523916
41	Abnormality of the calcaneus (HP:0008364)	2.72611591
42	Bundle branch block (HP:0011710)	2.70955051
43	Bulbar palsy (HP:0001283)	2.64814219
44	Slender build (HP:0001533)	2.60060606
45	Distal lower limb amyotrophy (HP:0008944)	2.57586396
46	Hyperkalemia (HP:0002153)	2.50155001
47	Weak cry (HP:0001612)	2.49900162
48	Gowers sign (HP:0003391)	2.42935311
49	Fatigable weakness (HP:0003473)	2.37809986
50	Abnormality of the neuromuscular junction (HP:0003398)	2.37809986
51	Hip contracture (HP:0003273)	2.37669797
52	Scapular winging (HP:0003691)	2.37018028
53	Limb-girdle muscle atrophy (HP:0003797)	2.29952401
54	Spinal rigidity (HP:0003306)	2.28940387
55	Dilated cardiomyopathy (HP:0001644)	2.28761682
56	Popliteal pterygium (HP:0009756)	2.18319859
57	Ventricular tachycardia (HP:0004756)	2.17334390
58	Progressive muscle weakness (HP:0003323)	2.15938365
59	Difficulty climbing stairs (HP:0003551)	2.09938326
60	Muscular dystrophy (HP:0003560)	2.07082632
61	Waddling gait (HP:0002515)	2.05678721
62	Lipoatrophy (HP:0100578)	2.02686705
63	Proximal amyotrophy (HP:0007126)	2.02523873
64	Metatarsus adductus (HP:0001840)	2.01805397
65	Muscle fiber inclusion bodies (HP:0100299)	11.3037813
66	Nemaline bodies (HP:0003798)	11.2837024
67	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	10.9956374
68	Lower limb amyotrophy (HP:0007210)	1.95949077
69	Long clavicles (HP:0000890)	1.94996930
70	Nonprogressive disorder (HP:0003680)	1.93019259
71	Abnormality of the foot musculature (HP:0001436)	1.92704594
72	Abnormality of the shoulder girdle musculature (HP:0001435)	1.90535311
73	Respiratory insufficiency due to muscle weakness (HP:0002747)	1.84516891
74	Foot dorsiflexor weakness (HP:0009027)	1.78734066
75	Type 2 muscle fiber atrophy (HP:0003554)	1.75887723
76	Ulnar deviation of finger (HP:0009465)	1.73983009
77	Abnormality of the hip-girdle musculature (HP:0001445)	1.73815412
78	Abnormality of the musculature of the pelvis (HP:0001469)	1.73815412
79	Facial diplegia (HP:0001349)	1.72523807
80	Heart block (HP:0012722)	1.71394832
81	Shoulder girdle muscle weakness (HP:0003547)	1.67011427
82	Paralysis (HP:0003470)	1.66335151
83	Pelvic girdle muscle weakness (HP:0003749)	1.66148219
84	Exercise intolerance (HP:0003546)	1.63001011
85	Limb-girdle muscle weakness (HP:0003325)	1.61765388
86	Muscle fiber atrophy (HP:0100295)	1.61309462
87	Abnormal atrioventricular conduction (HP:0005150)	1.61113575
88	Limited hip movement (HP:0008800)	1.60393840
89	Breech presentation (HP:0001623)	1.59700819
90	Ragged-red muscle fibers (HP:0003200)	1.57536202
91	Amniotic constriction ring (HP:0009775)	1.56252941
92	Abnormality of placental membranes (HP:0011409)	1.56252941
93	Aplasia of the musculature (HP:0100854)	1.47108738
94	Ulnar deviation of the hand or of fingers of the hand (HP:0001193)	1.44316603
95	Oligomenorrhea (HP:0000876)	1.42518058
96	Adducted thumb (HP:0001181)	1.39762025
97	Ventricular arrhythmia (HP:0004308)	1.37143211
98	Increased intramyocellular lipid droplets (HP:0012240)	1.36091179
99	Easy fatigability (HP:0003388)	1.32787812
100	Steppage gait (HP:0003376)	1.31296991

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PHKG1	5.84490414
2	PHKG2	5.84490414
3	TTN	5.82491248
4	PIK3CG	3.09325491
5	OBSCN	11.4074839
6	PINK1	1.92428419
7	MAPK12	1.89949095
8	MUSK	1.70984376
9	MAP2K3	1.67880231
10	MAP3K7	1.65449193
11	MOS	1.33262256
12	MAPKAPK3	1.31151812
13	TRPM7	1.29597722
14	EEF2K	1.17261963
15	NME1	1.15386250
16	CCNB1	1.11700714
17	MAP2K4	1.08600064
18	MARK1	0.95189380
19	NEK1	0.91067596
20	LIMK1	0.89564181
21	CAMK2G	0.86306741
22	DMPK	0.84630921
23	PRKAA2	0.80750183
24	MAP3K13	0.79228254
25	MAP2K6	0.75078395
26	ERBB3	0.73114916
27	AKT2	0.71812987
28	MAPK7	0.69044861
29	TRIB3	0.67178248
30	PDK2	0.66945383
31	DYRK1B	0.65303532
32	PRKAA1	0.63945860
33	RIPK1	0.61731865
34	NEK9	0.55074372
35	CAMK2B	0.54058516
36	CAMK4	0.51866828
37	KSR2	0.51263990
38	MAP2K1	0.50553113
39	PRKG1	0.50511012
40	MAPK11	0.49967331
41	MAPK4	0.49505762
42	PKN1	0.47398878
43	BCKDK	0.45926982
44	PIK3CA	0.44466793
45	SGK3	0.43945598
46	CAMK2D	0.43386768
47	TIE1	0.41914853
48	LATS2	0.41436686
49	ICK	0.39435276
50	CAMK2A	0.38177332
51	ROCK1	0.36830036
52	CAMK1	0.35231291
53	SGK2	0.33934195
54	MAP3K1	0.31951836
55	PRKACA	0.30341664
56	TBK1	0.29990278
57	ARAF	0.29125000
58	SGK1	0.26685989
59	RPS6KA3	0.25728465
60	EPHB1	0.25704217
61	RPS6KB1	0.25699256
62	MAP3K10	0.24942425
63	MAPK13	0.22881538
64	TAOK2	0.22353838
65	MARK2	0.20950783
66	LATS1	0.20853101
67	PRKACB	0.20708886
68	PDPK1	0.20513549
69	MAPK10	0.20186569
70	RPS6KB2	0.19701293
71	RPS6KA1	0.18470440
72	TGFBR2	0.18456392
73	SIK1	0.18156012
74	NLK	0.16611931
75	PDK1	0.16525297
76	CDK19	0.15927197
77	SGK494	0.15371781
78	SGK223	0.15371781
79	RPS6KL1	0.14679922
80	RPS6KC1	0.14679922
81	STK11	0.13703053
82	DAPK2	0.13328972
83	MTOR	0.13054383
84	PRPF4B	0.12577510
85	EPHA3	0.12399377
86	PRKACG	0.10834021
87	MAP3K9	0.10641412
88	RPS6KA6	0.10630171
89	RAF1	0.10412639
90	MAP3K6	0.10352295
91	PRKD1	0.08930197
92	MARK3	0.08561055
93	MAP3K11	0.07309682
94	MAP3K3	0.07107305
95	BRAF	0.05811894
96	FGFR3	0.05621622
97	MAPKAPK5	0.04787669
98	KSR1	0.03978097
99	RPS6KA2	0.03578752
100	ZAP70	0.03560132

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	4.60242843
2	Cardiac muscle contraction_Homo sapiens_hsa04260	4.16384145
3	Dilated cardiomyopathy_Homo sapiens_hsa05414	4.07012473
4	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	3.69278761
5	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.60619516
6	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	3.38939751
7	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	3.28837388
8	Circadian rhythm_Homo sapiens_hsa04710	2.97615388
9	Glucagon signaling pathway_Homo sapiens_hsa04922	2.36559347
10	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	2.22218607
11	Carbon metabolism_Homo sapiens_hsa01200	2.19769612
12	Insulin signaling pathway_Homo sapiens_hsa04910	2.12815532
13	Pentose phosphate pathway_Homo sapiens_hsa00030	2.09862065
14	Arginine and proline metabolism_Homo sapiens_hsa00330	2.03904555
15	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.86338983
16	Calcium signaling pathway_Homo sapiens_hsa04020	1.79907410
17	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.79481997
18	Arginine biosynthesis_Homo sapiens_hsa00220	1.77335891
19	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.75814566
20	Insulin resistance_Homo sapiens_hsa04931	1.67980980
21	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.61215397
22	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.59150765
23	Pyruvate metabolism_Homo sapiens_hsa00620	1.53062413
24	Alzheimers disease_Homo sapiens_hsa05010	1.49835323
25	Propanoate metabolism_Homo sapiens_hsa00640	1.48910351
26	Parkinsons disease_Homo sapiens_hsa05012	1.46215580
27	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.45141175
28	Fatty acid degradation_Homo sapiens_hsa00071	1.33388773
29	AMPK signaling pathway_Homo sapiens_hsa04152	1.32833509
30	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.29015182
31	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.28005873
32	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.23314723
33	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.13802904
34	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.11211847
35	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.09241905
36	Oxidative phosphorylation_Homo sapiens_hsa00190	1.06629695
37	Gastric acid secretion_Homo sapiens_hsa04971	1.02994142
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.02693759
39	Tight junction_Homo sapiens_hsa04530	1.02136019
40	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.00864847
41	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.99343724
42	Renin secretion_Homo sapiens_hsa04924	0.93081163
43	Phenylalanine metabolism_Homo sapiens_hsa00360	0.83574734
44	Focal adhesion_Homo sapiens_hsa04510	0.82697636
45	Fatty acid metabolism_Homo sapiens_hsa01212	0.81930180
46	GnRH signaling pathway_Homo sapiens_hsa04912	0.81515304
47	Galactose metabolism_Homo sapiens_hsa00052	0.80475841
48	Long-term potentiation_Homo sapiens_hsa04720	0.79280759
49	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.75295701
50	Viral myocarditis_Homo sapiens_hsa05416	0.74105496
51	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.61812646
52	Huntingtons disease_Homo sapiens_hsa05016	0.61348649
53	FoxO signaling pathway_Homo sapiens_hsa04068	0.60411271
54	Insulin secretion_Homo sapiens_hsa04911	0.57278774
55	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.57029091
56	beta-Alanine metabolism_Homo sapiens_hsa00410	0.55141824
57	Salivary secretion_Homo sapiens_hsa04970	0.52880751
58	Circadian entrainment_Homo sapiens_hsa04713	0.50970507
59	MAPK signaling pathway_Homo sapiens_hsa04010	0.50407460
60	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.49331336
61	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.46905189
62	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.45074126
63	PPAR signaling pathway_Homo sapiens_hsa03320	0.44044572
64	Tryptophan metabolism_Homo sapiens_hsa00380	0.43518798
65	Butanoate metabolism_Homo sapiens_hsa00650	0.42410250
66	Long-term depression_Homo sapiens_hsa04730	0.41456510
67	Amoebiasis_Homo sapiens_hsa05146	0.41354198
68	Lysine degradation_Homo sapiens_hsa00310	0.41188489
69	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.38504558
70	ECM-receptor interaction_Homo sapiens_hsa04512	0.37360730
71	Fatty acid elongation_Homo sapiens_hsa00062	0.35428555
72	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.34709096
73	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.33331199
74	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.32867348
75	Glioma_Homo sapiens_hsa05214	0.31572792
76	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.30786747
77	Histidine metabolism_Homo sapiens_hsa00340	0.30642865
78	mTOR signaling pathway_Homo sapiens_hsa04150	0.29944095
79	Peroxisome_Homo sapiens_hsa04146	0.29599428
80	cAMP signaling pathway_Homo sapiens_hsa04024	0.26468687
81	Protein digestion and absorption_Homo sapiens_hsa04974	0.26332714
82	Cholinergic synapse_Homo sapiens_hsa04725	0.26320999
83	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.25772661
84	VEGF signaling pathway_Homo sapiens_hsa04370	0.25401490
85	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.24245890
86	Platelet activation_Homo sapiens_hsa04611	0.23820565
87	Amphetamine addiction_Homo sapiens_hsa05031	0.22644926
88	Adherens junction_Homo sapiens_hsa04520	0.21827496
89	Regulation of autophagy_Homo sapiens_hsa04140	0.21372355
90	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.21011072
91	Bile secretion_Homo sapiens_hsa04976	0.20589849
92	Melanogenesis_Homo sapiens_hsa04916	0.20427030
93	Renal cell carcinoma_Homo sapiens_hsa05211	0.18886566
94	Pancreatic secretion_Homo sapiens_hsa04972	0.18458834
95	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.18117752
96	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.17165681
97	Thyroid cancer_Homo sapiens_hsa05216	0.14725369
98	Tyrosine metabolism_Homo sapiens_hsa00350	0.13503336
99	Olfactory transduction_Homo sapiens_hsa04740	0.12270087
100	Purine metabolism_Homo sapiens_hsa00230	0.11562000

CA3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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