CA5A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VA is localized in the mitochondria and expressed primarily in the liver. It may play an important role in ureagenesis and gluconeogenesis. CA5A gene maps to chromosome 16q24.3 and an unprocessed pseudogene has been assigned to 16p12-p11.2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.52009454
2L-fucose catabolic process (GO:0042355)5.09264567
3fucose catabolic process (GO:0019317)5.09264567
4L-fucose metabolic process (GO:0042354)5.09264567
5indole-containing compound catabolic process (GO:0042436)4.65422843
6indolalkylamine catabolic process (GO:0046218)4.65422843
7tryptophan catabolic process (GO:0006569)4.65422843
8kynurenine metabolic process (GO:0070189)4.55570227
9indolalkylamine metabolic process (GO:0006586)4.31512693
10tryptophan metabolic process (GO:0006568)3.93267318
11DNA deamination (GO:0045006)3.79839714
12cellular ketone body metabolic process (GO:0046950)3.69251291
13detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.62645285
14response to pheromone (GO:0019236)3.62551312
15sulfation (GO:0051923)3.57917081
16indole-containing compound metabolic process (GO:0042430)3.55761031
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.44747218
18gamma-aminobutyric acid transport (GO:0015812)3.41955907
19water-soluble vitamin biosynthetic process (GO:0042364)3.39563222
20detection of light stimulus involved in sensory perception (GO:0050962)3.36397018
21detection of light stimulus involved in visual perception (GO:0050908)3.36397018
22ketone body metabolic process (GO:1902224)3.30649387
23cellular response to ATP (GO:0071318)3.22070436
24primary amino compound metabolic process (GO:1901160)3.22029828
25negative regulation of telomere maintenance (GO:0032205)3.20076302
26regulation of hippo signaling (GO:0035330)3.17707127
27serotonin metabolic process (GO:0042428)3.12323054
28negative regulation of mast cell activation (GO:0033004)3.11896110
29neuronal action potential (GO:0019228)3.11406136
30oxidative demethylation (GO:0070989)3.03991841
31amine catabolic process (GO:0009310)3.03197219
32cellular biogenic amine catabolic process (GO:0042402)3.03197219
33regulation of nuclear cell cycle DNA replication (GO:0033262)3.02047238
34NAD biosynthetic process (GO:0009435)3.01915943
35drug catabolic process (GO:0042737)3.01427474
36exogenous drug catabolic process (GO:0042738)2.92590280
37regulation of posttranscriptional gene silencing (GO:0060147)2.92466158
38regulation of gene silencing by miRNA (GO:0060964)2.92466158
39regulation of gene silencing by RNA (GO:0060966)2.92466158
40piRNA metabolic process (GO:0034587)2.91239210
41aromatic amino acid family catabolic process (GO:0009074)2.85687964
42regulation of rhodopsin mediated signaling pathway (GO:0022400)2.84374110
43platelet dense granule organization (GO:0060155)2.83690911
44negative regulation of translation, ncRNA-mediated (GO:0040033)2.80662844
45regulation of translation, ncRNA-mediated (GO:0045974)2.80662844
46negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.80662844
47kidney morphogenesis (GO:0060993)2.79266550
48epithelial cilium movement (GO:0003351)2.79093447
49mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.76928845
50mitochondrial respiratory chain complex I assembly (GO:0032981)2.76928845
51NADH dehydrogenase complex assembly (GO:0010257)2.76928845
52behavioral response to ethanol (GO:0048149)2.76724294
53reflex (GO:0060004)2.76282436
54neural tube formation (GO:0001841)2.76063695
55basic amino acid transport (GO:0015802)2.73758929
56rhodopsin mediated signaling pathway (GO:0016056)2.73742176
57regulation of action potential (GO:0098900)2.73302891
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.72864302
59axoneme assembly (GO:0035082)2.72682508
60negative regulation of cytosolic calcium ion concentration (GO:0051481)2.72597268
61cAMP catabolic process (GO:0006198)2.72321707
62preassembly of GPI anchor in ER membrane (GO:0016254)2.70134657
63negative regulation of synaptic transmission, GABAergic (GO:0032229)2.68751895
64synaptic transmission, cholinergic (GO:0007271)2.68457547
65nonmotile primary cilium assembly (GO:0035058)2.67631953
66phosphatidylinositol acyl-chain remodeling (GO:0036149)2.66007380
673-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.65406202
68purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.65406202
69respiratory chain complex IV assembly (GO:0008535)2.64323196
70nephron epithelium morphogenesis (GO:0072088)2.63525665
71nephron tubule morphogenesis (GO:0072078)2.63525665
72protein complex biogenesis (GO:0070271)2.63477796
73regulation of mesoderm development (GO:2000380)2.61065032
74positive regulation of fatty acid oxidation (GO:0046321)2.60964359
75protein import into peroxisome matrix (GO:0016558)2.60628820
76somite development (GO:0061053)2.59392612
77positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.59028115
78negative regulation of reactive oxygen species metabolic process (GO:2000378)2.58764477
79fucosylation (GO:0036065)2.58688322
80positive regulation of sodium ion transmembrane transport (GO:1902307)2.57942830
81positive regulation of fatty acid transport (GO:2000193)2.56137761
82cilium or flagellum-dependent cell motility (GO:0001539)2.55242222
83DNA methylation involved in gamete generation (GO:0043046)2.54685717
84protein K11-linked deubiquitination (GO:0035871)2.54442914
85negative regulation of systemic arterial blood pressure (GO:0003085)2.53747334
86adaptation of signaling pathway (GO:0023058)2.52463161
87benzene-containing compound metabolic process (GO:0042537)2.51016547
88protein polyglutamylation (GO:0018095)2.50559461
89transmission of nerve impulse (GO:0019226)2.50390431
90multicellular organism reproduction (GO:0032504)2.50324549
91protein localization to cilium (GO:0061512)2.49956983
92reciprocal DNA recombination (GO:0035825)2.48130753
93reciprocal meiotic recombination (GO:0007131)2.48130753
94retinal cone cell development (GO:0046549)2.47823707
95positive regulation of oligodendrocyte differentiation (GO:0048714)2.47729491
96cornea development in camera-type eye (GO:0061303)2.47157448
97rRNA catabolic process (GO:0016075)2.46812277
98protein-cofactor linkage (GO:0018065)2.46609139
99positive regulation of defense response to virus by host (GO:0002230)2.46006573
100glycerophospholipid catabolic process (GO:0046475)2.45603371

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.07404199
2EZH2_22144423_ChIP-Seq_EOC_Human3.61616139
3VDR_22108803_ChIP-Seq_LS180_Human3.36404504
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.04702269
5GBX2_23144817_ChIP-Seq_PC3_Human2.96082880
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.57862885
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42634056
8IGF1R_20145208_ChIP-Seq_DFB_Human2.15373509
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11926636
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06574906
11FLI1_27457419_Chip-Seq_LIVER_Mouse1.99887583
12EWS_26573619_Chip-Seq_HEK293_Human1.96606492
13POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94225722
14TAF15_26573619_Chip-Seq_HEK293_Human1.88789474
15ER_23166858_ChIP-Seq_MCF-7_Human1.87930640
16FUS_26573619_Chip-Seq_HEK293_Human1.86629264
17P300_19829295_ChIP-Seq_ESCs_Human1.84369493
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.82378293
19NOTCH1_21737748_ChIP-Seq_TLL_Human1.69176549
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66476702
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65625993
22IRF1_19129219_ChIP-ChIP_H3396_Human1.61743301
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58018349
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56208195
25REST_21632747_ChIP-Seq_MESCs_Mouse1.55565551
26STAT3_23295773_ChIP-Seq_U87_Human1.55550016
27BCAT_22108803_ChIP-Seq_LS180_Human1.55031047
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54855627
29* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51268961
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.50754366
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50032260
32TP53_22573176_ChIP-Seq_HFKS_Human1.49955374
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49499496
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.48181895
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48050377
36NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46275966
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.44724308
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44538782
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39617566
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39617566
41TCF4_23295773_ChIP-Seq_U87_Human1.38807143
42AR_25329375_ChIP-Seq_VCAP_Human1.37982299
43FOXA1_25329375_ChIP-Seq_VCAP_Human1.36302748
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36302748
45AR_21572438_ChIP-Seq_LNCaP_Human1.35933797
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35046620
47CBP_20019798_ChIP-Seq_JUKART_Human1.35046620
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32797369
49SMAD4_21799915_ChIP-Seq_A2780_Human1.32091895
50SOX2_19829295_ChIP-Seq_ESCs_Human1.30566452
51NANOG_19829295_ChIP-Seq_ESCs_Human1.30566452
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30118743
53MYC_18940864_ChIP-ChIP_HL60_Human1.29614458
54EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27602785
55* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26745434
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.25483573
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25076494
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23237576
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22516982
60TCF4_22108803_ChIP-Seq_LS180_Human1.21478785
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21283530
62DROSHA_22980978_ChIP-Seq_HELA_Human1.19411358
63ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19310103
64RNF2_27304074_Chip-Seq_NSC_Mouse1.18954865
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18195028
66NCOR_22424771_ChIP-Seq_293T_Human1.17790291
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17531781
68NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16473890
69JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15738136
70HOXB7_26014856_ChIP-Seq_BT474_Human1.14087350
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13995832
72PRDM14_20953172_ChIP-Seq_ESCs_Human1.13861384
73* SMAD4_21741376_ChIP-Seq_EPCs_Human1.13748709
74* RUNX2_22187159_ChIP-Seq_PCA_Human1.12737607
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.12597010
76SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12551561
77AR_20517297_ChIP-Seq_VCAP_Human1.12244519
78EED_16625203_ChIP-ChIP_MESCs_Mouse1.11613379
79* SMAD3_21741376_ChIP-Seq_EPCs_Human1.10329814
80FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09779612
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.09224931
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06549357
83ERA_21632823_ChIP-Seq_H3396_Human1.06254433
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.04968202
85EZH2_27304074_Chip-Seq_ESCs_Mouse1.03620971
86TP53_16413492_ChIP-PET_HCT116_Human1.02471079
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01563804
88EZH2_27294783_Chip-Seq_ESCs_Mouse1.01082798
89TAF2_19829295_ChIP-Seq_ESCs_Human1.00192340
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98216778
91AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98143913
92REST_18959480_ChIP-ChIP_MESCs_Mouse0.98080266
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97702231
94SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97519931
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97251283
96MYC_19829295_ChIP-Seq_ESCs_Human0.97128467
97JARID2_20075857_ChIP-Seq_MESCs_Mouse0.93873255
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93542956
99FOXH1_21741376_ChIP-Seq_EPCs_Human0.93113797
100NANOG_20526341_ChIP-Seq_ESCs_Human0.92816514

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.49104164
2MP0003646_muscle_fatigue2.96766538
3MP0000569_abnormal_digit_pigmentation2.61003963
4MP0005551_abnormal_eye_electrophysiolog2.51603327
5MP0001986_abnormal_taste_sensitivity2.43183287
6MP0008875_abnormal_xenobiotic_pharmacok2.42521305
7MP0002102_abnormal_ear_morphology2.41470959
8MP0008877_abnormal_DNA_methylation2.38820333
9MP0001968_abnormal_touch/_nociception2.35233581
10MP0004043_abnormal_pH_regulation2.30907289
11MP0008872_abnormal_physiological_respon2.20180609
12MP0003136_yellow_coat_color2.14732131
13MP0005645_abnormal_hypothalamus_physiol2.03200355
14MP0004142_abnormal_muscle_tone2.03114261
15MP0002876_abnormal_thyroid_physiology2.03082373
16MP0009745_abnormal_behavioral_response2.02907671
17MP0002837_dystrophic_cardiac_calcinosis1.97968319
18MP0009046_muscle_twitch1.91392353
19MP0006292_abnormal_olfactory_placode1.82404723
20MP0002638_abnormal_pupillary_reflex1.81314445
21MP0005646_abnormal_pituitary_gland1.80031638
22MP0005174_abnormal_tail_pigmentation1.77344127
23MP0001501_abnormal_sleep_pattern1.75728351
24MP0003011_delayed_dark_adaptation1.75529724
25MP0002736_abnormal_nociception_after1.74084048
26MP0004885_abnormal_endolymph1.72270561
27MP0002653_abnormal_ependyma_morphology1.68906890
28MP0002272_abnormal_nervous_system1.67198673
29MP0004133_heterotaxia1.61754839
30MP0001485_abnormal_pinna_reflex1.61432472
31MP0000427_abnormal_hair_cycle1.60500434
32MP0005253_abnormal_eye_physiology1.51350439
33MP0003283_abnormal_digestive_organ1.48868125
34MP0006072_abnormal_retinal_apoptosis1.45790223
35MP0004147_increased_porphyrin_level1.45269417
36MP0002160_abnormal_reproductive_system1.39938736
37MP0005389_reproductive_system_phenotype1.39765888
38MP0002735_abnormal_chemical_nociception1.37714496
39MP0000631_abnormal_neuroendocrine_gland1.37491021
40MP0002938_white_spotting1.37170697
41MP0005084_abnormal_gallbladder_morpholo1.37101269
42MP0002064_seizures1.36957214
43MP0002928_abnormal_bile_duct1.36135306
44MP0004742_abnormal_vestibular_system1.35880864
45MP0005085_abnormal_gallbladder_physiolo1.35631065
46MP0001486_abnormal_startle_reflex1.34803140
47MP0004145_abnormal_muscle_electrophysio1.29399900
48MP0004130_abnormal_muscle_cell1.29310195
49MP0002572_abnormal_emotion/affect_behav1.29143062
50MP0003787_abnormal_imprinting1.27067153
51MP0002234_abnormal_pharynx_morphology1.26875298
52MP0003252_abnormal_bile_duct1.26845844
53MP0001919_abnormal_reproductive_system1.24020414
54MP0006276_abnormal_autonomic_nervous1.22484041
55MP0002138_abnormal_hepatobiliary_system1.21846625
56MP0001970_abnormal_pain_threshold1.21117798
57MP0002733_abnormal_thermal_nociception1.17156475
58MP0005167_abnormal_blood-brain_barrier1.15625365
59MP0002557_abnormal_social/conspecific_i1.15084833
60MP0010329_abnormal_lipoprotein_level1.14285161
61MP0010386_abnormal_urinary_bladder1.11512856
62MP0004924_abnormal_behavior1.09391194
63MP0005386_behavior/neurological_phenoty1.09391194
64MP0003880_abnormal_central_pattern1.08740273
65MP0002067_abnormal_sensory_capabilities1.08153570
66MP0005423_abnormal_somatic_nervous1.06156663
67MP0000383_abnormal_hair_follicle1.06118582
68MP0003119_abnormal_digestive_system1.03802194
69MP0000372_irregular_coat_pigmentation1.01961079
70MP0002063_abnormal_learning/memory/cond1.01715193
71MP0003878_abnormal_ear_physiology1.01067809
72MP0005377_hearing/vestibular/ear_phenot1.01067809
73MP0005195_abnormal_posterior_eye1.00588607
74MP0000230_abnormal_systemic_arterial0.98820845
75MP0003635_abnormal_synaptic_transmissio0.98187078
76MP0002095_abnormal_skin_pigmentation0.95280642
77MP0005365_abnormal_bile_salt0.93046038
78MP0005332_abnormal_amino_acid0.90409811
79MP0000026_abnormal_inner_ear0.89918937
80MP0005410_abnormal_fertilization0.88429631
81MP0002277_abnormal_respiratory_mucosa0.87295794
82MP0001905_abnormal_dopamine_level0.86992378
83MP0003718_maternal_effect0.86446086
84MP0001324_abnormal_eye_pigmentation0.85838613
85MP0001502_abnormal_circadian_rhythm0.84965605
86MP0008775_abnormal_heart_ventricle0.84583375
87MP0002752_abnormal_somatic_nervous0.80956636
88MP0000538_abnormal_urinary_bladder0.80280513
89MP0002734_abnormal_mechanical_nocicepti0.79457410
90MP0005448_abnormal_energy_balance0.79051842
91MP0003890_abnormal_embryonic-extraembry0.78941300
92MP0002693_abnormal_pancreas_physiology0.76840564
93MP0009764_decreased_sensitivity_to0.76539190
94MP0003698_abnormal_male_reproductive0.75564706
95MP0001984_abnormal_olfaction0.75324254
96MP0008961_abnormal_basal_metabolism0.74957866
97MP0000470_abnormal_stomach_morphology0.74379441
98MP0001664_abnormal_digestion0.74157523
99MP0001963_abnormal_hearing_physiology0.73789905
100MP0001529_abnormal_vocalization0.72669117

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.87434141
2Congenital stationary night blindness (HP:0007642)4.56641186
3Pancreatic fibrosis (HP:0100732)4.16602804
4Molar tooth sign on MRI (HP:0002419)4.15023128
5Abnormality of midbrain morphology (HP:0002418)4.15023128
6True hermaphroditism (HP:0010459)3.97009198
7Nephronophthisis (HP:0000090)3.59151221
8Type II lissencephaly (HP:0007260)3.54887354
9Attenuation of retinal blood vessels (HP:0007843)3.54060073
10Abnormality of the renal cortex (HP:0011035)3.31647597
11Abnormality of the renal medulla (HP:0100957)3.14732991
12Hyperventilation (HP:0002883)3.11147682
13Abolished electroretinogram (ERG) (HP:0000550)3.08121864
14Pendular nystagmus (HP:0012043)3.02950664
15Cystic liver disease (HP:0006706)2.96648386
16Tubular atrophy (HP:0000092)2.91561228
17Chronic hepatic failure (HP:0100626)2.89954781
18Genetic anticipation (HP:0003743)2.82486519
19Polydipsia (HP:0001959)2.81178180
20Abnormal drinking behavior (HP:0030082)2.81178180
21Chorioretinal atrophy (HP:0000533)2.81088599
22Inability to walk (HP:0002540)2.77934913
23Large for gestational age (HP:0001520)2.65518074
24Medial flaring of the eyebrow (HP:0010747)2.63869085
25Decreased circulating renin level (HP:0003351)2.62891463
26Increased corneal curvature (HP:0100692)2.61290964
27Keratoconus (HP:0000563)2.61290964
28Progressive cerebellar ataxia (HP:0002073)2.61062249
29Gaze-evoked nystagmus (HP:0000640)2.58335397
30Decreased central vision (HP:0007663)2.57304028
31Concave nail (HP:0001598)2.55346584
32Progressive inability to walk (HP:0002505)2.54009876
33Congenital, generalized hypertrichosis (HP:0004540)2.53580888
34Absent/shortened dynein arms (HP:0200106)2.50065842
35Dynein arm defect of respiratory motile cilia (HP:0012255)2.50065842
36Bile duct proliferation (HP:0001408)2.47464064
37Abnormal biliary tract physiology (HP:0012439)2.47464064
38Decreased electroretinogram (ERG) amplitude (HP:0000654)2.46312936
39Abnormal rod and cone electroretinograms (HP:0008323)2.44661326
40Sclerocornea (HP:0000647)2.44194580
41Cerebellar dysplasia (HP:0007033)2.43491407
42Lissencephaly (HP:0001339)2.42750644
43Clumsiness (HP:0002312)2.41959418
44Abnormality of the pons (HP:0007361)2.41874491
45Furrowed tongue (HP:0000221)2.34765508
46Protruding tongue (HP:0010808)2.34152334
47Hypoplasia of the pons (HP:0012110)2.30845311
48Bony spicule pigmentary retinopathy (HP:0007737)2.22486869
49Renal cortical cysts (HP:0000803)2.22142533
50Patellar aplasia (HP:0006443)2.21732148
51Polyuria (HP:0000103)2.20676505
52Aplasia/Hypoplasia of the tibia (HP:0005772)2.20448009
53Congenital sensorineural hearing impairment (HP:0008527)2.20351501
54Severe muscular hypotonia (HP:0006829)2.17726248
55Aplasia/Hypoplasia of the patella (HP:0006498)2.16498610
56Congenital hepatic fibrosis (HP:0002612)2.09095268
57Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08589968
58Male pseudohermaphroditism (HP:0000037)2.07426326
59Anencephaly (HP:0002323)2.06411820
60Stomach cancer (HP:0012126)2.05964728
61Febrile seizures (HP:0002373)2.05032191
62Aplasia/Hypoplasia of the tongue (HP:0010295)2.05018630
63Broad-based gait (HP:0002136)2.04831982
64Birth length less than 3rd percentile (HP:0003561)2.04815281
65Abnormality of the renal collecting system (HP:0004742)2.03050320
66Gait imbalance (HP:0002141)1.98577913
67Abnormal respiratory epithelium morphology (HP:0012253)1.98081968
68Abnormal respiratory motile cilium morphology (HP:0005938)1.98081968
69Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92681898
70Fair hair (HP:0002286)1.90309883
71Congenital primary aphakia (HP:0007707)1.89627707
72Rib fusion (HP:0000902)1.84732665
73Duplicated collecting system (HP:0000081)1.83369825
74Optic nerve hypoplasia (HP:0000609)1.81744827
75Absent thumb (HP:0009777)1.81666194
76Abnormal ciliary motility (HP:0012262)1.80715624
77Pachygyria (HP:0001302)1.80425337
78Bilateral microphthalmos (HP:0007633)1.78695137
79Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.77855719
80Abnormal urine output (HP:0012590)1.77811453
81Hypothermia (HP:0002045)1.77328562
82Hemiparesis (HP:0001269)1.77040440
83Aplasia/Hypoplasia of the spleen (HP:0010451)1.75770689
84Abnormal number of erythroid precursors (HP:0012131)1.75065272
85Methylmalonic acidemia (HP:0002912)1.74608544
86Small hand (HP:0200055)1.74422871
87Optic disc pallor (HP:0000543)1.73460438
88Methylmalonic aciduria (HP:0012120)1.72242990
89Genital tract atresia (HP:0001827)1.71793015
90Nephrogenic diabetes insipidus (HP:0009806)1.71538280
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.69310042
92Postaxial foot polydactyly (HP:0001830)1.68659570
93Retinal dysplasia (HP:0007973)1.66072576
94Vaginal atresia (HP:0000148)1.66048156
95Absent speech (HP:0001344)1.65711502
96Partial agenesis of the corpus callosum (HP:0001338)1.65686049
97Widely spaced teeth (HP:0000687)1.61010936
98Hyperglycinuria (HP:0003108)1.59528753
99Dandy-Walker malformation (HP:0001305)1.59071429
100Agitation (HP:0000713)1.56955241

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.19781473
2ADRBK23.83453945
3BMPR1B3.19968874
4WNK43.17895830
5ACVR1B3.05226530
6TLK12.93957650
7ZAK2.86963684
8GRK12.80074476
9TAOK32.38075812
10PINK12.34241293
11INSRR2.31471117
12WNK32.13978831
13MAP4K21.98707577
14DAPK21.92876886
15MAPK131.88633565
16NUAK11.79846844
17TXK1.66023359
18STK391.59282710
19OXSR11.58477948
20CASK1.56836868
21ADRBK11.50758195
22PNCK1.50557724
23MAP3K41.27065910
24TGFBR11.20871258
25CAMKK21.18311638
26MAPK151.12891371
27MAPKAPK31.12531266
28MKNK21.07125558
29PAK31.03322248
30MUSK0.98290131
31PRKCG0.95818210
32PIK3CA0.95616682
33MARK10.85739026
34TNIK0.85274511
35PRKCE0.82898028
36DYRK20.82731141
37NTRK30.79613518
38MAP2K60.77996158
39IKBKB0.74448331
40TIE10.74346356
41KIT0.74187443
42MAPKAPK50.71404362
43STK38L0.64847377
44PRKCQ0.64557993
45CAMK10.62154944
46RPS6KA50.62088371
47NEK20.61850759
48NTRK20.60987014
49PHKG20.60856774
50PHKG10.60856774
51TEC0.60732004
52AKT30.60729768
53PTK2B0.60579474
54BRSK20.60506443
55IRAK10.59074420
56STK110.56705251
57RPS6KA60.56501030
58MAP2K70.55665711
59WEE10.54688341
60BCKDK0.53584158
61CHUK0.52950519
62VRK10.52884231
63PKN10.52724961
64WNK10.51617237
65SIK20.50964950
66SYK0.50778277
67CAMK2A0.50415915
68ITK0.48341348
69PRKACA0.47242404
70PLK20.44777619
71TRPM70.44290207
72SGK20.44139747
73GRK70.43054531
74TNK20.42729103
75PRKAA20.42643745
76MAP2K10.41603035
77FGFR20.41274545
78NLK0.40652189
79PRKCI0.40106785
80PRKCZ0.39858394
81CSNK1G20.39783300
82MAP2K20.38136541
83CAMKK10.37177185
84OBSCN0.36614538
85STK30.36306733
86ERBB20.35994435
87PRKCA0.35467480
88NME10.35320239
89CSNK1G10.34216946
90CSNK1A10.32775671
91CHEK20.32761351
92CSNK1D0.32395349
93PRKG10.31684931
94MKNK10.30890485
95SGK4940.29927781
96SGK2230.29927781
97CAMK40.29905008
98PRKAA10.28797278
99STK160.28274165
100TRIM280.28250237

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005913.00479291
2Phototransduction_Homo sapiens_hsa047442.93689435
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.81871917
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.61498508
5Nicotine addiction_Homo sapiens_hsa050332.36236459
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.28693999
7Butanoate metabolism_Homo sapiens_hsa006502.26181750
8Caffeine metabolism_Homo sapiens_hsa002322.23445679
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.21606690
10Selenocompound metabolism_Homo sapiens_hsa004502.19272796
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.16799631
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.14432927
13Tryptophan metabolism_Homo sapiens_hsa003802.09727689
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02900844
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.01377049
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.84463658
17Ether lipid metabolism_Homo sapiens_hsa005651.80870297
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76698874
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.75237611
20Homologous recombination_Homo sapiens_hsa034401.65125032
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.57430196
22Taste transduction_Homo sapiens_hsa047421.54400257
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.52253002
24* Nitrogen metabolism_Homo sapiens_hsa009101.48103791
25Oxidative phosphorylation_Homo sapiens_hsa001901.47823432
26Morphine addiction_Homo sapiens_hsa050321.46269252
27ABC transporters_Homo sapiens_hsa020101.42958670
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.42075046
29Chemical carcinogenesis_Homo sapiens_hsa052041.41166696
30RNA polymerase_Homo sapiens_hsa030201.34319771
31Olfactory transduction_Homo sapiens_hsa047401.34227886
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.33017695
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.32977148
34Fanconi anemia pathway_Homo sapiens_hsa034601.26486571
35Arachidonic acid metabolism_Homo sapiens_hsa005901.25803775
36Basal transcription factors_Homo sapiens_hsa030221.21181163
37Retinol metabolism_Homo sapiens_hsa008301.18640062
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15180230
39Peroxisome_Homo sapiens_hsa041461.12287175
40Histidine metabolism_Homo sapiens_hsa003401.11699118
41Sulfur relay system_Homo sapiens_hsa041221.11603526
42Insulin secretion_Homo sapiens_hsa049111.06829210
43Serotonergic synapse_Homo sapiens_hsa047261.06453891
44One carbon pool by folate_Homo sapiens_hsa006701.04350826
45Parkinsons disease_Homo sapiens_hsa050121.02000226
46Circadian entrainment_Homo sapiens_hsa047131.01592221
47Ovarian steroidogenesis_Homo sapiens_hsa049131.00879156
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98174859
49Glycerolipid metabolism_Homo sapiens_hsa005610.96478428
50GABAergic synapse_Homo sapiens_hsa047270.95628345
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94755660
52Glutamatergic synapse_Homo sapiens_hsa047240.94539947
53Fat digestion and absorption_Homo sapiens_hsa049750.93422644
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89555439
55Cardiac muscle contraction_Homo sapiens_hsa042600.88983784
56Calcium signaling pathway_Homo sapiens_hsa040200.85289324
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81319185
58Propanoate metabolism_Homo sapiens_hsa006400.79925290
59beta-Alanine metabolism_Homo sapiens_hsa004100.76110446
60Vitamin digestion and absorption_Homo sapiens_hsa049770.75221732
61RNA degradation_Homo sapiens_hsa030180.74631529
62Sulfur metabolism_Homo sapiens_hsa009200.73166584
63Salivary secretion_Homo sapiens_hsa049700.72762410
64Protein export_Homo sapiens_hsa030600.71401431
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69093834
66Huntingtons disease_Homo sapiens_hsa050160.66385991
67Regulation of autophagy_Homo sapiens_hsa041400.65037454
68Mineral absorption_Homo sapiens_hsa049780.63908908
69Asthma_Homo sapiens_hsa053100.63367328
70Primary immunodeficiency_Homo sapiens_hsa053400.63222834
71Alzheimers disease_Homo sapiens_hsa050100.63043679
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61778549
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59816625
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.59242503
75Dorso-ventral axis formation_Homo sapiens_hsa043200.57657321
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57288654
77Metabolic pathways_Homo sapiens_hsa011000.49329747
78Purine metabolism_Homo sapiens_hsa002300.49078781
79Fatty acid biosynthesis_Homo sapiens_hsa000610.48739791
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46589165
81Cocaine addiction_Homo sapiens_hsa050300.46060114
82Fatty acid degradation_Homo sapiens_hsa000710.44945122
83Long-term depression_Homo sapiens_hsa047300.44735891
84Dopaminergic synapse_Homo sapiens_hsa047280.43826077
85cAMP signaling pathway_Homo sapiens_hsa040240.43393371
86Collecting duct acid secretion_Homo sapiens_hsa049660.42080523
87Cholinergic synapse_Homo sapiens_hsa047250.40489689
88Graft-versus-host disease_Homo sapiens_hsa053320.39570794
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38759493
90Bile secretion_Homo sapiens_hsa049760.38152807
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38125492
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.38003199
93Gastric acid secretion_Homo sapiens_hsa049710.37109038
94Type I diabetes mellitus_Homo sapiens_hsa049400.35124374
95Oxytocin signaling pathway_Homo sapiens_hsa049210.32667934
96Amphetamine addiction_Homo sapiens_hsa050310.31948295
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31931112
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29436963
99Ribosome_Homo sapiens_hsa030100.29093304
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.28405430

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »