

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 6.38194922 |
| 2 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.37513491 |
| 3 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.26619986 |
| 4 | cullin deneddylation (GO:0010388) | 4.24307222 |
| 5 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.20402682 |
| 6 | protein deneddylation (GO:0000338) | 4.16481208 |
| 7 | negative regulation of ligase activity (GO:0051352) | 4.04878843 |
| 8 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.04878843 |
| 9 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 4.01014792 |
| 10 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.97779204 |
| 11 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.94867635 |
| 12 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.93549379 |
| 13 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.88269132 |
| 14 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.88269132 |
| 15 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.88269132 |
| 16 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.87127842 |
| 17 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.87127842 |
| 18 | DNA strand elongation (GO:0022616) | 3.81649766 |
| 19 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.72130996 |
| 20 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.72130996 |
| 21 | establishment of integrated proviral latency (GO:0075713) | 3.71485546 |
| 22 | establishment of viral latency (GO:0019043) | 3.71072151 |
| 23 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.70284624 |
| 24 | chaperone-mediated protein transport (GO:0072321) | 3.61980150 |
| 25 | chromatin remodeling at centromere (GO:0031055) | 3.61361309 |
| 26 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.61285911 |
| 27 | DNA deamination (GO:0045006) | 3.61080746 |
| 28 | CENP-A containing nucleosome assembly (GO:0034080) | 3.57181754 |
| 29 | ribosome assembly (GO:0042255) | 3.52114730 |
| 30 | respiratory chain complex IV assembly (GO:0008535) | 3.51412221 |
| 31 | protein targeting to mitochondrion (GO:0006626) | 3.49945071 |
| 32 | positive regulation of ligase activity (GO:0051351) | 3.48837575 |
| 33 | rRNA modification (GO:0000154) | 3.46148755 |
| 34 | histone H2A acetylation (GO:0043968) | 3.42434981 |
| 35 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.34215748 |
| 36 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.33962765 |
| 37 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.30834995 |
| 38 | regulation of mitochondrial translation (GO:0070129) | 3.29774589 |
| 39 | spliceosomal snRNP assembly (GO:0000387) | 3.29630694 |
| 40 | DNA replication checkpoint (GO:0000076) | 3.27737300 |
| 41 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 3.26947069 |
| 42 | cytochrome complex assembly (GO:0017004) | 3.26863780 |
| 43 | pseudouridine synthesis (GO:0001522) | 3.24894714 |
| 44 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.24887364 |
| 45 | regulation of ligase activity (GO:0051340) | 3.24652646 |
| 46 | histone mRNA metabolic process (GO:0008334) | 3.18349268 |
| 47 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.16639373 |
| 48 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.16639373 |
| 49 | NADH dehydrogenase complex assembly (GO:0010257) | 3.16639373 |
| 50 | protein complex biogenesis (GO:0070271) | 3.16291840 |
| 51 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.15816422 |
| 52 | establishment of protein localization to mitochondrion (GO:0072655) | 3.15065916 |
| 53 | termination of RNA polymerase III transcription (GO:0006386) | 3.12775374 |
| 54 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.12775374 |
| 55 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.12440318 |
| 56 | negative regulation of protein ubiquitination (GO:0031397) | 3.12330018 |
| 57 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.11833003 |
| 58 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.09775283 |
| 59 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.09730578 |
| 60 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.09730578 |
| 61 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.08623200 |
| 62 | maturation of 5.8S rRNA (GO:0000460) | 3.06317570 |
| 63 | protein localization to mitochondrion (GO:0070585) | 3.04896472 |
| 64 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.02585355 |
| 65 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.00617043 |
| 66 | positive regulation of cell cycle arrest (GO:0071158) | 2.99431212 |
| 67 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.95988123 |
| 68 | cell cycle G1/S phase transition (GO:0044843) | 2.95988123 |
| 69 | metallo-sulfur cluster assembly (GO:0031163) | 2.95963143 |
| 70 | iron-sulfur cluster assembly (GO:0016226) | 2.95963143 |
| 71 | DNA unwinding involved in DNA replication (GO:0006268) | 2.95155634 |
| 72 | negative regulation of protein modification by small protein conjugation or removal (GO:1903321) | 2.95114611 |
| 73 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.95010371 |
| 74 | transcription from mitochondrial promoter (GO:0006390) | 2.93091643 |
| 75 | protein maturation by protein folding (GO:0022417) | 2.93001738 |
| 76 | peptidyl-histidine modification (GO:0018202) | 2.91567103 |
| 77 | DNA replication initiation (GO:0006270) | 2.89547642 |
| 78 | regulation of cellular amine metabolic process (GO:0033238) | 2.88040776 |
| 79 | replication fork processing (GO:0031297) | 2.85564201 |
| 80 | histone exchange (GO:0043486) | 2.85176441 |
| 81 | pteridine-containing compound biosynthetic process (GO:0042559) | 2.84206921 |
| 82 | DNA damage response, detection of DNA damage (GO:0042769) | 2.83664014 |
| 83 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 2.82123271 |
| 84 | purine nucleobase biosynthetic process (GO:0009113) | 2.81530844 |
| 85 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.79550676 |
| 86 | deoxyribonucleotide catabolic process (GO:0009264) | 2.78400531 |
| 87 | signal transduction in response to DNA damage (GO:0042770) | 2.78309113 |
| 88 | rRNA methylation (GO:0031167) | 2.77116866 |
| 89 | IMP biosynthetic process (GO:0006188) | 2.75621531 |
| 90 | mitochondrial RNA metabolic process (GO:0000959) | 2.75194689 |
| 91 | deoxyribose phosphate catabolic process (GO:0046386) | 2.74229110 |
| 92 | base-excision repair (GO:0006284) | 2.72573877 |
| 93 | telomere maintenance via recombination (GO:0000722) | 2.71050060 |
| 94 | DNA double-strand break processing (GO:0000729) | 2.70988242 |
| 95 | histone mRNA catabolic process (GO:0071044) | 2.70530440 |
| 96 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.69890166 |
| 97 | DNA replication-independent nucleosome organization (GO:0034724) | 2.69890166 |
| 98 | mitotic recombination (GO:0006312) | 2.69248857 |
| 99 | non-recombinational repair (GO:0000726) | 2.68488919 |
| 100 | double-strand break repair via nonhomologous end joining (GO:0006303) | 2.68488919 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.97899488 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.11609317 |
| 3 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 4.14596991 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.06792065 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.83490877 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.81027645 |
| 7 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.36070527 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.33500974 |
| 9 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.13008207 |
| 10 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.03027968 |
| 11 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.96752806 |
| 12 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.91658024 |
| 13 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.83501053 |
| 14 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.68510539 |
| 15 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.65133738 |
| 16 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.59892008 |
| 17 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.57357240 |
| 18 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.53782239 |
| 19 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.48716226 |
| 20 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.46198847 |
| 21 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.43772302 |
| 22 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.35863982 |
| 23 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.31326640 |
| 24 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.27514314 |
| 25 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.26262729 |
| 26 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.26208902 |
| 27 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.25513072 |
| 28 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.22257602 |
| 29 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.14812636 |
| 30 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.12600744 |
| 31 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.11744600 |
| 32 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.10501608 |
| 33 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 2.08659657 |
| 34 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.08651120 |
| 35 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.91971812 |
| 36 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.88184946 |
| 37 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.86245871 |
| 38 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.85850446 |
| 39 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.78032858 |
| 40 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.71325684 |
| 41 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.70947381 |
| 42 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.65436596 |
| 43 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.63147869 |
| 44 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.59397014 |
| 45 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.59075005 |
| 46 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.57783368 |
| 47 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.57485602 |
| 48 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.56597542 |
| 49 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.55963471 |
| 50 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.53158529 |
| 51 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.50688877 |
| 52 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.44039908 |
| 53 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.41505297 |
| 54 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.40601823 |
| 55 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.39020226 |
| 56 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.38187862 |
| 57 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.33695004 |
| 58 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.33383211 |
| 59 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.32957866 |
| 60 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.32133294 |
| 61 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.30298869 |
| 62 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.29958292 |
| 63 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.29476100 |
| 64 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.28829315 |
| 65 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.28369021 |
| 66 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.22617541 |
| 67 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.16313149 |
| 68 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.15721639 |
| 69 | * SPI1_23547873_ChIP-Seq_NB4_Human | 1.14213955 |
| 70 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.13984066 |
| 71 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.13517499 |
| 72 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.08150721 |
| 73 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.05516266 |
| 74 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.01772265 |
| 75 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.00097533 |
| 76 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.97507132 |
| 77 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.97429171 |
| 78 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.96439285 |
| 79 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.93078706 |
| 80 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.90644887 |
| 81 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.90577109 |
| 82 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.89308130 |
| 83 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.88797620 |
| 84 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.85213831 |
| 85 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.81631785 |
| 86 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.79522311 |
| 87 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.75451850 |
| 88 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.74880563 |
| 89 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.74311127 |
| 90 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.74281594 |
| 91 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 0.73953766 |
| 92 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.72115440 |
| 93 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.71702989 |
| 94 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.66467910 |
| 95 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.64031052 |
| 96 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.63593966 |
| 97 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.61247352 |
| 98 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.60985474 |
| 99 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.60165784 |
| 100 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.59608586 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0000372_irregular_coat_pigmentation | 4.69458641 |
| 2 | MP0008058_abnormal_DNA_repair | 4.35910714 |
| 3 | MP0010094_abnormal_chromosome_stability | 3.88742695 |
| 4 | MP0003806_abnormal_nucleotide_metabolis | 3.23351791 |
| 5 | MP0003111_abnormal_nucleus_morphology | 3.13832416 |
| 6 | MP0003186_abnormal_redox_activity | 2.94543609 |
| 7 | MP0006035_abnormal_mitochondrial_morpho | 2.92928588 |
| 8 | MP0003693_abnormal_embryo_hatching | 2.92072656 |
| 9 | MP0006036_abnormal_mitochondrial_physio | 2.79930695 |
| 10 | MP0003786_premature_aging | 2.73397403 |
| 11 | MP0003718_maternal_effect | 2.71852407 |
| 12 | MP0005075_abnormal_melanosome_morpholog | 2.71753990 |
| 13 | MP0003077_abnormal_cell_cycle | 2.51831848 |
| 14 | MP0008260_abnormal_autophagy | 2.45677732 |
| 15 | MP0004957_abnormal_blastocyst_morpholog | 2.45369618 |
| 16 | MP0000015_abnormal_ear_pigmentation | 2.33552661 |
| 17 | MP0004147_increased_porphyrin_level | 2.31105457 |
| 18 | MP0008877_abnormal_DNA_methylation | 2.28403291 |
| 19 | MP0008932_abnormal_embryonic_tissue | 2.27787720 |
| 20 | MP0009697_abnormal_copulation | 2.17695220 |
| 21 | MP0005171_absent_coat_pigmentation | 2.17051257 |
| 22 | MP0008057_abnormal_DNA_replication | 2.16133201 |
| 23 | MP0003136_yellow_coat_color | 2.07267106 |
| 24 | MP0002254_reproductive_system_inflammat | 1.95547539 |
| 25 | MP0008007_abnormal_cellular_replicative | 1.92709834 |
| 26 | MP0000358_abnormal_cell_content/ | 1.90574322 |
| 27 | MP0003172_abnormal_lysosome_physiology | 1.75444018 |
| 28 | MP0005174_abnormal_tail_pigmentation | 1.62622700 |
| 29 | MP0005408_hypopigmentation | 1.58720619 |
| 30 | MP0003656_abnormal_erythrocyte_physiolo | 1.55668729 |
| 31 | MP0003950_abnormal_plasma_membrane | 1.55170112 |
| 32 | MP0001764_abnormal_homeostasis | 1.52092944 |
| 33 | MP0002837_dystrophic_cardiac_calcinosis | 1.49757718 |
| 34 | MP0005397_hematopoietic_system_phenotyp | 1.44554889 |
| 35 | MP0001545_abnormal_hematopoietic_system | 1.44554889 |
| 36 | MP0006054_spinal_hemorrhage | 1.36253659 |
| 37 | MP0001730_embryonic_growth_arrest | 1.26733860 |
| 38 | MP0001853_heart_inflammation | 1.26631514 |
| 39 | MP0003890_abnormal_embryonic-extraembry | 1.25468930 |
| 40 | MP0000313_abnormal_cell_death | 1.25327032 |
| 41 | MP0001529_abnormal_vocalization | 1.25280515 |
| 42 | MP0002095_abnormal_skin_pigmentation | 1.25101177 |
| 43 | MP0002132_abnormal_respiratory_system | 1.22322461 |
| 44 | MP0002938_white_spotting | 1.18448888 |
| 45 | MP0002102_abnormal_ear_morphology | 1.17301530 |
| 46 | MP0003221_abnormal_cardiomyocyte_apopto | 1.16995431 |
| 47 | MP0008995_early_reproductive_senescence | 1.15346657 |
| 48 | MP0002148_abnormal_hypersensitivity_rea | 1.12826423 |
| 49 | MP0005670_abnormal_white_adipose | 1.09853250 |
| 50 | MP0001324_abnormal_eye_pigmentation | 1.09075094 |
| 51 | MP0003191_abnormal_cellular_cholesterol | 1.07560372 |
| 52 | MP0001697_abnormal_embryo_size | 1.06583099 |
| 53 | MP0000350_abnormal_cell_proliferation | 1.05421469 |
| 54 | MP0005058_abnormal_lysosome_morphology | 1.05368553 |
| 55 | MP0002877_abnormal_melanocyte_morpholog | 1.04630360 |
| 56 | MP0002090_abnormal_vision | 1.03068200 |
| 57 | MP0000569_abnormal_digit_pigmentation | 1.00988340 |
| 58 | MP0009840_abnormal_foam_cell | 0.97653220 |
| 59 | MP0001929_abnormal_gametogenesis | 0.97191509 |
| 60 | MP0005464_abnormal_platelet_physiology | 0.95216772 |
| 61 | MP0008873_increased_physiological_sensi | 0.92926761 |
| 62 | MP0009333_abnormal_splenocyte_physiolog | 0.91810573 |
| 63 | MP0002080_prenatal_lethality | 0.90641894 |
| 64 | MP0003646_muscle_fatigue | 0.90391833 |
| 65 | MP0002019_abnormal_tumor_incidence | 0.88094452 |
| 66 | MP0002210_abnormal_sex_determination | 0.87606907 |
| 67 | MP0004381_abnormal_hair_follicle | 0.87503588 |
| 68 | MP0002736_abnormal_nociception_after | 0.85263096 |
| 69 | MP0005384_cellular_phenotype | 0.82096531 |
| 70 | MP0005380_embryogenesis_phenotype | 0.82092220 |
| 71 | MP0001672_abnormal_embryogenesis/_devel | 0.82092220 |
| 72 | MP0005395_other_phenotype | 0.80998870 |
| 73 | MP0002396_abnormal_hematopoietic_system | 0.80158999 |
| 74 | MP0005330_cardiomyopathy | 0.78241125 |
| 75 | MP0001145_abnormal_male_reproductive | 0.76620351 |
| 76 | MP0000653_abnormal_sex_gland | 0.76582376 |
| 77 | MP0000749_muscle_degeneration | 0.74222872 |
| 78 | MP0000689_abnormal_spleen_morphology | 0.73029948 |
| 79 | MP0005410_abnormal_fertilization | 0.72670130 |
| 80 | MP0008789_abnormal_olfactory_epithelium | 0.70174060 |
| 81 | MP0005266_abnormal_metabolism | 0.68595726 |
| 82 | MP0010307_abnormal_tumor_latency | 0.68129950 |
| 83 | MP0001119_abnormal_female_reproductive | 0.67055726 |
| 84 | MP0000516_abnormal_urinary_system | 0.66500817 |
| 85 | MP0005367_renal/urinary_system_phenotyp | 0.66500817 |
| 86 | MP0001873_stomach_inflammation | 0.66224501 |
| 87 | MP0000371_diluted_coat_color | 0.64661482 |
| 88 | MP0003123_paternal_imprinting | 0.62141360 |
| 89 | MP0001727_abnormal_embryo_implantation | 0.61951098 |
| 90 | MP0009278_abnormal_bone_marrow | 0.61809650 |
| 91 | MP0000343_altered_response_to | 0.61220344 |
| 92 | MP0006072_abnormal_retinal_apoptosis | 0.60535905 |
| 93 | MP0003984_embryonic_growth_retardation | 0.60157475 |
| 94 | MP0005551_abnormal_eye_electrophysiolog | 0.59972788 |
| 95 | MP0005253_abnormal_eye_physiology | 0.59775403 |
| 96 | MP0002722_abnormal_immune_system | 0.58791198 |
| 97 | MP0002075_abnormal_coat/hair_pigmentati | 0.58362457 |
| 98 | MP0002429_abnormal_blood_cell | 0.57842792 |
| 99 | MP0006276_abnormal_autonomic_nervous | 0.56732124 |
| 100 | MP0005319_abnormal_enzyme/_coenzyme | 0.56647167 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.49241312 |
| 2 | Acute encephalopathy (HP:0006846) | 4.25952894 |
| 3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.10884412 |
| 4 | Mitochondrial inheritance (HP:0001427) | 3.82453161 |
| 5 | Increased CSF lactate (HP:0002490) | 3.77849439 |
| 6 | Progressive macrocephaly (HP:0004481) | 3.77210654 |
| 7 | Hepatocellular necrosis (HP:0001404) | 3.56463701 |
| 8 | Abnormality of glycolysis (HP:0004366) | 3.35934301 |
| 9 | Increased serum pyruvate (HP:0003542) | 3.25520587 |
| 10 | Cholecystitis (HP:0001082) | 3.25093687 |
| 11 | Abnormal gallbladder physiology (HP:0012438) | 3.25093687 |
| 12 | Hepatic necrosis (HP:0002605) | 3.21401010 |
| 13 | Carpal bone hypoplasia (HP:0001498) | 3.14514945 |
| 14 | Petechiae (HP:0000967) | 3.07884925 |
| 15 | Type I transferrin isoform profile (HP:0003642) | 2.98851207 |
| 16 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.98673120 |
| 17 | Microvesicular hepatic steatosis (HP:0001414) | 2.88943936 |
| 18 | Cerebral edema (HP:0002181) | 2.88215088 |
| 19 | Increased serum lactate (HP:0002151) | 2.83159958 |
| 20 | Abnormality of alanine metabolism (HP:0010916) | 2.79019710 |
| 21 | Hyperalaninemia (HP:0003348) | 2.79019710 |
| 22 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.79019710 |
| 23 | Lactic acidosis (HP:0003128) | 2.76150986 |
| 24 | Chromsome breakage (HP:0040012) | 2.72678193 |
| 25 | Degeneration of anterior horn cells (HP:0002398) | 2.72347170 |
| 26 | Abnormality of the anterior horn cell (HP:0006802) | 2.72347170 |
| 27 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.60279807 |
| 28 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.60279807 |
| 29 | Respiratory failure (HP:0002878) | 2.55712540 |
| 30 | Microretrognathia (HP:0000308) | 2.52233495 |
| 31 | Exercise intolerance (HP:0003546) | 2.47307558 |
| 32 | Pancytopenia (HP:0001876) | 2.43982152 |
| 33 | Cutaneous melanoma (HP:0012056) | 2.43495969 |
| 34 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.42393431 |
| 35 | Rough bone trabeculation (HP:0100670) | 2.41219393 |
| 36 | Albinism (HP:0001022) | 2.37552437 |
| 37 | Poor head control (HP:0002421) | 2.32474757 |
| 38 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.32205615 |
| 39 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.32205615 |
| 40 | Abnormal protein glycosylation (HP:0012346) | 2.32205615 |
| 41 | Abnormal glycosylation (HP:0012345) | 2.32205615 |
| 42 | Delusions (HP:0000746) | 2.29055740 |
| 43 | CNS demyelination (HP:0007305) | 2.25793747 |
| 44 | Aplastic anemia (HP:0001915) | 2.25537529 |
| 45 | Reduced antithrombin III activity (HP:0001976) | 2.24710718 |
| 46 | Multiple enchondromatosis (HP:0005701) | 2.21963472 |
| 47 | Progressive inability to walk (HP:0002505) | 2.21648199 |
| 48 | Cerebral hypomyelination (HP:0006808) | 2.20994577 |
| 49 | Methylmalonic aciduria (HP:0012120) | 2.17606127 |
| 50 | Emotional lability (HP:0000712) | 2.16105466 |
| 51 | Respiratory difficulties (HP:0002880) | 2.15851903 |
| 52 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 2.13810636 |
| 53 | Hypoplasia of the fovea (HP:0007750) | 2.13810636 |
| 54 | Patchy hypopigmentation of hair (HP:0011365) | 2.11261027 |
| 55 | Spastic paraparesis (HP:0002313) | 2.10371919 |
| 56 | Abnormality of the preputium (HP:0100587) | 2.09209270 |
| 57 | Methylmalonic acidemia (HP:0002912) | 2.09068925 |
| 58 | Hepatosplenomegaly (HP:0001433) | 2.05034766 |
| 59 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.03838146 |
| 60 | Lethargy (HP:0001254) | 2.03699406 |
| 61 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.03475388 |
| 62 | Optic disc pallor (HP:0000543) | 2.02890654 |
| 63 | Neoplasm of the adrenal gland (HP:0100631) | 2.02735491 |
| 64 | X-linked dominant inheritance (HP:0001423) | 1.99432713 |
| 65 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.98983789 |
| 66 | Meckel diverticulum (HP:0002245) | 1.98687291 |
| 67 | White forelock (HP:0002211) | 1.97121530 |
| 68 | Short middle phalanx of the 5th finger (HP:0004220) | 1.96451869 |
| 69 | Abnormality of the fovea (HP:0000493) | 1.95291879 |
| 70 | Renal Fanconi syndrome (HP:0001994) | 1.94876049 |
| 71 | Progressive microcephaly (HP:0000253) | 1.94848874 |
| 72 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.92809358 |
| 73 | Constricted visual fields (HP:0001133) | 1.91800250 |
| 74 | 3-Methylglutaconic aciduria (HP:0003535) | 1.90972034 |
| 75 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.90842649 |
| 76 | Nausea (HP:0002018) | 1.90505302 |
| 77 | Progressive muscle weakness (HP:0003323) | 1.89558025 |
| 78 | Premature ovarian failure (HP:0008209) | 1.89526912 |
| 79 | Abnormality of chromosome stability (HP:0003220) | 1.88882206 |
| 80 | Leukodystrophy (HP:0002415) | 1.88091377 |
| 81 | Aplasia/Hypoplasia of the macula (HP:0008059) | 1.88003974 |
| 82 | Increased hepatocellular lipid droplets (HP:0006565) | 1.85748226 |
| 83 | Secondary amenorrhea (HP:0000869) | 1.84179632 |
| 84 | Abnormality of the ileum (HP:0001549) | 1.83007918 |
| 85 | Ragged-red muscle fibers (HP:0003200) | 1.82006690 |
| 86 | Upper limb muscle weakness (HP:0003484) | 1.81542193 |
| 87 | Postnatal microcephaly (HP:0005484) | 1.80680226 |
| 88 | Bone marrow hypocellularity (HP:0005528) | 1.80591062 |
| 89 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.80461728 |
| 90 | Abnormality of lateral ventricle (HP:0030047) | 1.78497839 |
| 91 | Vacuolated lymphocytes (HP:0001922) | 1.78447299 |
| 92 | Cleft eyelid (HP:0000625) | 1.75863443 |
| 93 | Volvulus (HP:0002580) | 1.75035864 |
| 94 | Gliosis (HP:0002171) | 1.74422158 |
| 95 | Abnormal gallbladder morphology (HP:0012437) | 1.74389182 |
| 96 | Abnormality of the fetal cardiovascular system (HP:0010948) | 1.70844476 |
| 97 | Abnormal umbilical cord blood vessels (HP:0011403) | 1.70844476 |
| 98 | Single umbilical artery (HP:0001195) | 1.70844476 |
| 99 | Diaphragmatic weakness (HP:0009113) | 1.69309549 |
| 100 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.68967885 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PDK2 | 4.22129000 |
| 2 | TRIM28 | 4.00052306 |
| 3 | NEK1 | 3.51023786 |
| 4 | VRK2 | 3.38398988 |
| 5 | BUB1 | 3.36608556 |
| 6 | EIF2AK1 | 2.91295965 |
| 7 | SRPK1 | 2.71079054 |
| 8 | SIK3 | 2.49411883 |
| 9 | CDC7 | 2.42088094 |
| 10 | EIF2AK3 | 2.40700102 |
| 11 | NME2 | 2.32510394 |
| 12 | MST4 | 2.20309390 |
| 13 | STK16 | 2.02743686 |
| 14 | PBK | 1.87393271 |
| 15 | BCKDK | 1.86802867 |
| 16 | TTK | 1.78561038 |
| 17 | BRSK2 | 1.72615809 |
| 18 | PLK4 | 1.64156380 |
| 19 | PLK3 | 1.59783580 |
| 20 | TSSK6 | 1.58605658 |
| 21 | CSNK1G3 | 1.58048547 |
| 22 | WEE1 | 1.55353887 |
| 23 | PIM2 | 1.51224945 |
| 24 | ZAK | 1.46078046 |
| 25 | STK38L | 1.43038064 |
| 26 | MKNK1 | 1.33751737 |
| 27 | NME1 | 1.31965369 |
| 28 | BMPR1B | 1.29650285 |
| 29 | IRAK3 | 1.29313319 |
| 30 | CSNK1G1 | 1.28828575 |
| 31 | CSNK1G2 | 1.28793905 |
| 32 | ERBB3 | 1.28248703 |
| 33 | TESK2 | 1.27373014 |
| 34 | NUAK1 | 1.25214948 |
| 35 | VRK1 | 1.23924502 |
| 36 | BRSK1 | 1.20629067 |
| 37 | PLK2 | 1.18121538 |
| 38 | CCNB1 | 1.17861523 |
| 39 | DAPK1 | 1.15782944 |
| 40 | MKNK2 | 1.13722465 |
| 41 | CSNK1A1L | 1.11970192 |
| 42 | MARK3 | 1.11588816 |
| 43 | PLK1 | 1.10070976 |
| 44 | MAP3K12 | 1.05221902 |
| 45 | WNK3 | 1.03049918 |
| 46 | RPS6KA4 | 1.02601419 |
| 47 | STK10 | 0.99544093 |
| 48 | MAP4K2 | 0.90902009 |
| 49 | ATR | 0.86748421 |
| 50 | CHEK2 | 0.84067194 |
| 51 | KDR | 0.83090499 |
| 52 | BCR | 0.82647958 |
| 53 | TESK1 | 0.78788754 |
| 54 | ABL2 | 0.78389464 |
| 55 | TNK2 | 0.67911469 |
| 56 | PAK4 | 0.66470549 |
| 57 | MAP3K8 | 0.65673415 |
| 58 | CLK1 | 0.63161204 |
| 59 | ARAF | 0.63110784 |
| 60 | PRKCI | 0.62072898 |
| 61 | EIF2AK2 | 0.61349497 |
| 62 | LIMK1 | 0.58705230 |
| 63 | BRAF | 0.57776862 |
| 64 | CSNK2A1 | 0.55486123 |
| 65 | NEK2 | 0.55107893 |
| 66 | MAPKAPK3 | 0.51921960 |
| 67 | RPS6KA5 | 0.50302477 |
| 68 | ATM | 0.47950247 |
| 69 | IKBKB | 0.46999541 |
| 70 | MAP3K3 | 0.45846433 |
| 71 | FER | 0.45648552 |
| 72 | TEC | 0.44277835 |
| 73 | AURKB | 0.44110394 |
| 74 | CSNK2A2 | 0.43940061 |
| 75 | TAOK2 | 0.43673702 |
| 76 | PAK1 | 0.43612704 |
| 77 | DYRK2 | 0.43287006 |
| 78 | CHEK1 | 0.41628909 |
| 79 | MAPKAPK5 | 0.41555868 |
| 80 | IRAK4 | 0.40576559 |
| 81 | DYRK3 | 0.40308867 |
| 82 | CDK7 | 0.40149757 |
| 83 | MATK | 0.39456983 |
| 84 | MAP3K5 | 0.38153523 |
| 85 | KIT | 0.37839814 |
| 86 | STK4 | 0.36824405 |
| 87 | FLT3 | 0.36379538 |
| 88 | CDK19 | 0.35637871 |
| 89 | AURKA | 0.35524603 |
| 90 | TYK2 | 0.34077642 |
| 91 | BMPR2 | 0.32840709 |
| 92 | TNIK | 0.32509022 |
| 93 | SCYL2 | 0.31879444 |
| 94 | MAP2K3 | 0.29566202 |
| 95 | TAF1 | 0.27017019 |
| 96 | ACVR1B | 0.26718461 |
| 97 | PTK2B | 0.25240946 |
| 98 | PINK1 | 0.24421471 |
| 99 | RAF1 | 0.24209877 |
| 100 | FRK | 0.23908934 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.16582087 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 3.65085545 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.92876138 |
| 4 | Mismatch repair_Homo sapiens_hsa03430 | 2.83531729 |
| 5 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.77564596 |
| 6 | Base excision repair_Homo sapiens_hsa03410 | 2.76727528 |
| 7 | RNA polymerase_Homo sapiens_hsa03020 | 2.71195661 |
| 8 | Protein export_Homo sapiens_hsa03060 | 2.44690659 |
| 9 | Homologous recombination_Homo sapiens_hsa03440 | 2.27991459 |
| 10 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.26157397 |
| 11 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.19995613 |
| 12 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.11294853 |
| 13 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.10083969 |
| 14 | Parkinsons disease_Homo sapiens_hsa05012 | 2.03910083 |
| 15 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.00580205 |
| 16 | Spliceosome_Homo sapiens_hsa03040 | 1.93201087 |
| 17 | Basal transcription factors_Homo sapiens_hsa03022 | 1.92444739 |
| 18 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.90751986 |
| 19 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.88933635 |
| 20 | RNA transport_Homo sapiens_hsa03013 | 1.87755935 |
| 21 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.87270880 |
| 22 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.80473813 |
| 23 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.64383615 |
| 24 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.62484295 |
| 25 | RNA degradation_Homo sapiens_hsa03018 | 1.59712718 |
| 26 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.50961936 |
| 27 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.47617347 |
| 28 | Huntingtons disease_Homo sapiens_hsa05016 | 1.45338604 |
| 29 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.43316480 |
| 30 | Cell cycle_Homo sapiens_hsa04110 | 1.38459659 |
| 31 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.33422180 |
| 32 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.32275451 |
| 33 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.30867906 |
| 34 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.26869870 |
| 35 | Purine metabolism_Homo sapiens_hsa00230 | 1.25789643 |
| 36 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.23474406 |
| 37 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.21220389 |
| 38 | Carbon metabolism_Homo sapiens_hsa01200 | 1.19689316 |
| 39 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.17276021 |
| 40 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.14084902 |
| 41 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.13381913 |
| 42 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.07428319 |
| 43 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.05356708 |
| 44 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.95134868 |
| 45 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.94747723 |
| 46 | Alzheimers disease_Homo sapiens_hsa05010 | 0.93236438 |
| 47 | Sulfur relay system_Homo sapiens_hsa04122 | 0.91333077 |
| 48 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.91131123 |
| 49 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.85975437 |
| 50 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.84374353 |
| 51 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.83613308 |
| 52 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.83598122 |
| 53 | Galactose metabolism_Homo sapiens_hsa00052 | 0.83245714 |
| 54 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.81914001 |
| 55 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.79750455 |
| 56 | Peroxisome_Homo sapiens_hsa04146 | 0.79400873 |
| 57 | Metabolic pathways_Homo sapiens_hsa01100 | 0.77557738 |
| 58 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.76398990 |
| 59 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.75392312 |
| 60 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.73941696 |
| 61 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.68840661 |
| 62 | Ribosome_Homo sapiens_hsa03010 | 0.64256490 |
| 63 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.62319601 |
| 64 | Asthma_Homo sapiens_hsa05310 | 0.59661906 |
| 65 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.58957277 |
| 66 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.58706974 |
| 67 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.58667838 |
| 68 | Legionellosis_Homo sapiens_hsa05134 | 0.55674396 |
| 69 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.52887586 |
| 70 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.52141996 |
| 71 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.51420099 |
| 72 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.50860770 |
| 73 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.50708187 |
| 74 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.50705621 |
| 75 | Other glycan degradation_Homo sapiens_hsa00511 | 0.47789485 |
| 76 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.47475765 |
| 77 | Lysosome_Homo sapiens_hsa04142 | 0.45657915 |
| 78 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.45455240 |
| 79 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.42563169 |
| 80 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.41896162 |
| 81 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.40843365 |
| 82 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.40453900 |
| 83 | Shigellosis_Homo sapiens_hsa05131 | 0.38654790 |
| 84 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.38576268 |
| 85 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.35244285 |
| 86 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.34467735 |
| 87 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.33620099 |
| 88 | Phototransduction_Homo sapiens_hsa04744 | 0.30803933 |
| 89 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.28325807 |
| 90 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.28300279 |
| 91 | Circadian rhythm_Homo sapiens_hsa04710 | 0.27627619 |
| 92 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.26700380 |
| 93 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.25751864 |
| 94 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.18347513 |
| 95 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.17842019 |
| 96 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.17222283 |
| 97 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.16968566 |
| 98 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.15990535 |
| 99 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.14910663 |
| 100 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.14606633 |

