CAB39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to endosome (GO:0036010)5.18496825
2positive regulation of gamma-delta T cell activation (GO:0046645)5.17018584
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.85209979
4regulation of B cell receptor signaling pathway (GO:0050855)4.32204688
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.21191246
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.21191246
7modulation by symbiont of host immune response (GO:0052553)4.21191246
8positive regulation by symbiont of host defense response (GO:0052509)4.21191246
9modulation by symbiont of host defense response (GO:0052031)4.21191246
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.21191246
11cellular potassium ion homeostasis (GO:0030007)4.16727140
12sodium ion export (GO:0071436)4.14649849
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.05717096
14regulation of gamma-delta T cell activation (GO:0046643)3.85409959
15antigen processing and presentation of endogenous antigen (GO:0019883)3.79146641
16regulation of gamma-delta T cell differentiation (GO:0045586)3.79012762
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.72625721
18macrophage activation involved in immune response (GO:0002281)3.72358134
19negative regulation of cell killing (GO:0031342)3.69735244
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.69735244
21detection of other organism (GO:0098543)3.64544791
22response to interleukin-15 (GO:0070672)3.57675758
23neutrophil activation involved in immune response (GO:0002283)3.55214780
24negative regulation of erythrocyte differentiation (GO:0045647)3.52228323
25regulation of clathrin-mediated endocytosis (GO:2000369)3.49112108
26positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.46976975
27cytoskeletal anchoring at plasma membrane (GO:0007016)3.46846312
28negative regulation of T cell mediated immunity (GO:0002710)3.46502410
29layer formation in cerebral cortex (GO:0021819)3.44334251
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.40642208
31B cell receptor signaling pathway (GO:0050853)3.40298413
32detection of molecule of bacterial origin (GO:0032490)3.38407000
33synaptic vesicle maturation (GO:0016188)3.36990331
34regulation of ARF protein signal transduction (GO:0032012)3.36641706
35cellular extravasation (GO:0045123)3.31221173
36regulation of interferon-beta biosynthetic process (GO:0045357)3.30363084
37negative regulation of lymphocyte mediated immunity (GO:0002707)3.29328502
38detection of bacterium (GO:0016045)3.26699493
39plasma membrane repair (GO:0001778)3.24964436
40locomotory exploration behavior (GO:0035641)3.23503063
41signal complex assembly (GO:0007172)3.23365209
42negative thymic T cell selection (GO:0045060)3.22756449
43positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.22508914
44detection of external biotic stimulus (GO:0098581)3.21465121
45negative T cell selection (GO:0043383)3.19493798
46cellular response to interleukin-15 (GO:0071350)3.17524047
47negative regulation of interleukin-12 production (GO:0032695)3.17039333
48regulation of short-term neuronal synaptic plasticity (GO:0048172)3.14915639
49leukocyte aggregation (GO:0070486)3.13632927
50germinal center formation (GO:0002467)3.13549181
51response to peptidoglycan (GO:0032494)3.08955600
52regulation of translational termination (GO:0006449)3.08358887
53nerve growth factor signaling pathway (GO:0038180)3.02379700
54positive thymic T cell selection (GO:0045059)3.01507710
55regulation of necroptotic process (GO:0060544)3.00465409
56positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.00428635
57negative regulation of leukocyte mediated immunity (GO:0002704)3.00189506
58labyrinthine layer development (GO:0060711)3.00044438
59potassium ion import (GO:0010107)2.99664277
60activation of protein kinase A activity (GO:0034199)2.97983532
61positive regulation of cellular amide metabolic process (GO:0034250)2.95398087
62response to host (GO:0075136)2.90402200
63response to host defenses (GO:0052200)2.90402200
64response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.90402200
65response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.88132210
66response to host immune response (GO:0052572)2.88132210
67regulation of synaptic vesicle exocytosis (GO:2000300)2.87980545
68response to muramyl dipeptide (GO:0032495)2.82407301
69clathrin coat assembly (GO:0048268)2.79597658
70protein targeting to Golgi (GO:0000042)2.77940052
71microglial cell activation (GO:0001774)2.77184690
72vesicle transport along microtubule (GO:0047496)2.75525653
73positive T cell selection (GO:0043368)2.74367636
74thymic T cell selection (GO:0045061)2.74125504
75T cell selection (GO:0045058)2.73578995
76macrophage activation (GO:0042116)2.73261294
77neutrophil activation (GO:0042119)2.72967047
78stress fiber assembly (GO:0043149)2.72929646
79regulation of early endosome to late endosome transport (GO:2000641)2.72700345
80cytoplasmic mRNA processing body assembly (GO:0033962)2.72585818
81myeloid cell activation involved in immune response (GO:0002275)2.69117559
82cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.68247067
83regulation of ARF GTPase activity (GO:0032312)2.68223294
84detection of biotic stimulus (GO:0009595)2.67745336
85regulation of leukocyte degranulation (GO:0043300)2.65614983
86cellular response to nerve growth factor stimulus (GO:1990090)2.64883288
87response to nerve growth factor (GO:1990089)2.64883288
88negative regulation of type 2 immune response (GO:0002829)2.63323590
89establishment of nucleus localization (GO:0040023)2.62985949
90negative regulation of necroptotic process (GO:0060546)2.62939497
91lipopolysaccharide-mediated signaling pathway (GO:0031663)2.62403417
92regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.61667014
93cell communication involved in cardiac conduction (GO:0086065)2.61112335
94positive regulation of B cell differentiation (GO:0045579)2.59819798
95tolerance induction (GO:0002507)2.59163231
96immunoglobulin mediated immune response (GO:0016064)2.59073092
97regulation of nucleobase-containing compound transport (GO:0032239)2.58967299
98neuromuscular process controlling balance (GO:0050885)2.58801653
99* peptidyl-threonine modification (GO:0018210)2.58680786
100antigen processing and presentation via MHC class Ib (GO:0002475)2.58673266
101granulocyte activation (GO:0036230)2.58411278
102cellular sodium ion homeostasis (GO:0006883)2.57974443
103* peptidyl-threonine phosphorylation (GO:0018107)2.57972599
104regulation of mast cell degranulation (GO:0043304)2.57958211
105T cell migration (GO:0072678)2.57627627
106establishment of protein localization to Golgi (GO:0072600)2.57360928
107regulation of macrophage cytokine production (GO:0010935)2.56733334
108regulation of platelet aggregation (GO:0090330)2.56526779
109regulation of tolerance induction (GO:0002643)2.56302204
110JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.56104674
111interferon-gamma-mediated signaling pathway (GO:0060333)2.54303599
112regulation of myeloid leukocyte mediated immunity (GO:0002886)2.52422252
113potassium ion homeostasis (GO:0055075)2.52201462
114positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.51810034
115glutamate secretion (GO:0014047)2.50821060
116regulation of T cell tolerance induction (GO:0002664)2.50775369
117regulation of RNA export from nucleus (GO:0046831)2.50484676
118cellular response to thyroid hormone stimulus (GO:0097067)2.49827016
119regulation of B cell differentiation (GO:0045577)2.48937463
120regulation of T-helper 2 cell differentiation (GO:0045628)2.48269535
121positive regulation of mast cell activation (GO:0033005)2.48036817
122regulation of cAMP-dependent protein kinase activity (GO:2000479)2.47846239
123negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.47681991
124membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.47401817
125negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.47052429
126positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.45033259
127embryonic process involved in female pregnancy (GO:0060136)2.44965683
128dendritic cell chemotaxis (GO:0002407)2.44928738
129negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.44771851
130dendritic cell migration (GO:0036336)2.44305628
131regulation of synaptic vesicle transport (GO:1902803)2.44166497
132regulation of natural killer cell mediated immunity (GO:0002715)2.43156946
133regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.43156946
134negative regulation of toll-like receptor signaling pathway (GO:0034122)2.41646397
135negative regulation of interleukin-17 production (GO:0032700)2.41061735
136G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.41037829
137negative regulation of T-helper cell differentiation (GO:0045623)2.40663849
138negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.40663849
139regulation of dendritic spine morphogenesis (GO:0061001)2.40425025
140positive regulation of macrophage cytokine production (GO:0060907)2.40056929
141* hypotonic response (GO:0006971)2.39783057
142production of molecular mediator involved in inflammatory response (GO:0002532)2.38533563
143regulation of regulated secretory pathway (GO:1903305)2.37118137
144organelle transport along microtubule (GO:0072384)2.36651887
145cell communication by electrical coupling (GO:0010644)2.36637333
146proline transport (GO:0015824)2.34356046
147synaptic vesicle exocytosis (GO:0016079)2.34170781
148growth hormone receptor signaling pathway (GO:0060396)2.32741121
149dendritic spine morphogenesis (GO:0060997)2.32059498
150intestinal epithelial cell development (GO:0060576)2.31731124
151* negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.31112914
152retrograde transport, vesicle recycling within Golgi (GO:0000301)2.29946635
153positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.29849498
154dendrite morphogenesis (GO:0048813)2.29830627
155regulation of sodium ion transmembrane transporter activity (GO:2000649)2.28995661
156positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.28984078
157regulation of synapse structural plasticity (GO:0051823)2.28730743
158regulation of Rac protein signal transduction (GO:0035020)2.27997163
159positive regulation of sodium ion transport (GO:0010765)2.24459589
160synaptic vesicle docking involved in exocytosis (GO:0016081)2.21760039
161carnitine shuttle (GO:0006853)2.21562439
162mating behavior (GO:0007617)2.20308521
163lipid translocation (GO:0034204)2.18915762
164phospholipid translocation (GO:0045332)2.18915762
165protein targeting to lysosome (GO:0006622)2.17142848
166establishment of protein localization to vacuole (GO:0072666)2.17142848
167protein targeting to vacuole (GO:0006623)2.17142848
168NLS-bearing protein import into nucleus (GO:0006607)2.16942817
169cellular response to arsenic-containing substance (GO:0071243)2.16046128
170receptor catabolic process (GO:0032801)2.15328391
171positive regulation of lamellipodium assembly (GO:0010592)2.15207212
172exploration behavior (GO:0035640)2.11433861
173positive regulation of vesicle fusion (GO:0031340)2.10136938
174negative regulation of GTP catabolic process (GO:0033125)2.09478181
175negative regulation of GTPase activity (GO:0034260)2.09478181
176neurotransmitter secretion (GO:0007269)2.08775250
177localization within membrane (GO:0051668)2.08342424
178cortical actin cytoskeleton organization (GO:0030866)2.07350185
179mitotic G1 DNA damage checkpoint (GO:0031571)2.05606302
180positive regulation of Rap GTPase activity (GO:0032854)2.05603539
181positive regulation of histone deacetylation (GO:0031065)2.05542022
182epithelial cell differentiation involved in prostate gland development (GO:0060742)2.04951534
183hemidesmosome assembly (GO:0031581)2.04860482
184relaxation of cardiac muscle (GO:0055119)2.04732048
185positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.04568502
186sarcoplasmic reticulum calcium ion transport (GO:0070296)2.04232203
187vocalization behavior (GO:0071625)2.04122569
188regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.04115528
189N-glycan processing (GO:0006491)2.03791193
190activation of JUN kinase activity (GO:0007257)2.01059987
191regulation of glutamate receptor signaling pathway (GO:1900449)2.00505691
192endoplasmic reticulum organization (GO:0007029)1.99977926

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.69850373
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.52511786
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.50150575
4ZNF263_19887448_ChIP-Seq_K562_Human2.92417520
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.77443670
6IRF8_27001747_Chip-Seq_BMDM_Mouse2.72808226
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.49691795
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.39111477
9TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.16212915
10GATA1_22025678_ChIP-Seq_K562_Human2.12950942
11KDM2B_26808549_Chip-Seq_DND41_Human2.09882346
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.03707947
13* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.02676717
14SCL_19346495_ChIP-Seq_HPC-7_Human2.01708324
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.97720573
16KDM2B_26808549_Chip-Seq_K562_Human1.96128276
17KDM2B_26808549_Chip-Seq_SUP-B15_Human1.94457670
18MYB_26560356_Chip-Seq_TH2_Human1.92002164
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90282733
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.87993050
21VDR_24763502_ChIP-Seq_THP-1_Human1.86256286
22KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.85211014
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.81548182
24* RARB_27405468_Chip-Seq_BRAIN_Mouse1.81436766
25AR_21572438_ChIP-Seq_LNCaP_Human1.80542648
26* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.79811811
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.79417889
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.79367167
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.78804151
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.77302538
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74370236
32CLOCK_20551151_ChIP-Seq_293T_Human1.74236925
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.72978690
34ESR1_20079471_ChIP-ChIP_T-47D_Human1.71351773
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.70133666
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.69720753
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69049971
38VDR_24787735_ChIP-Seq_THP-1_Human1.66157681
39VDR_21846776_ChIP-Seq_THP-1_Human1.65304472
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62651200
41* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.61781277
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60671696
43GATA1_19941827_ChIP-Seq_MEL_Mouse1.60610421
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58435999
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.58036825
46* KDM2B_26808549_Chip-Seq_JURKAT_Human1.57529636
47* SPI1_23547873_ChIP-Seq_NB4_Human1.56724282
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.55779064
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55332920
50* MYB_26560356_Chip-Seq_TH1_Human1.53862907
51KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.51714293
52TCF7_22412390_ChIP-Seq_EML_Mouse1.51547512
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48497531
54DROSHA_22980978_ChIP-Seq_HELA_Human1.47968855
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.47543471
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44996305
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.43987254
58* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.41476212
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41087326
60* PU_27001747_Chip-Seq_BMDM_Mouse1.40451235
61ZFP281_27345836_Chip-Seq_ESCs_Mouse1.38781517
62RXR_22108803_ChIP-Seq_LS180_Human1.38360549
63ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.37086159
64UTX_26944678_Chip-Seq_JUKART_Human1.36384139
65RACK7_27058665_Chip-Seq_MCF-7_Human1.35422585
66CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.35203416
67RUNX1_27514584_Chip-Seq_MCF-7_Human1.35115984
68STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.32670261
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32274188
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32100982
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31207023
72NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.30694052
73EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29709507
74GATA3_27048872_Chip-Seq_THYMUS_Human1.29262872
75* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26712492
76AHR_22903824_ChIP-Seq_MCF-7_Human1.24149438
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.23560701
78CREB1_26743006_Chip-Seq_LNCaP_Human1.23020510
79DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20292057
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18817053
81MYC_22102868_ChIP-Seq_BL_Human1.15214790
82Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14043513
83GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12314728
84TP53_16413492_ChIP-PET_HCT116_Human1.11853451
85MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11745991
86SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11745349
87SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11745349
88SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11452732
89THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11262705
90DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10484404
91ATF3_27146783_Chip-Seq_COLON_Human1.10260168
92ESR1_21235772_ChIP-Seq_MCF-7_Human1.09402736
93MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08722702
94LXR_22292898_ChIP-Seq_THP-1_Human1.08642646
95CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08067905
96PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07193914
97* ELK3_25401928_ChIP-Seq_HUVEC_Human1.07093904
98CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06524489
99RUNX_20019798_ChIP-Seq_JUKART_Human1.06304132
100GATA1_19941826_ChIP-Seq_K562_Human1.06115756
101GATA1_19941827_ChIP-Seq_MEL86_Mouse1.06045869
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05655310
103WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04557784
104FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.03497715
105* MAF_26560356_Chip-Seq_TH2_Human1.03080551
106ZNF274_21170338_ChIP-Seq_K562_Hela1.03056181
107SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02455579
108* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01983047
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01564554
110FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.01505510
111CDX2_20551321_ChIP-Seq_CACO-2_Human1.01297801
112SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00995255
113MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00356418
114ARNT_22903824_ChIP-Seq_MCF-7_Human1.00196092
115MYB_21317192_ChIP-Seq_ERMYB_Mouse0.99350376
116NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98924995
117* SPI1_23127762_ChIP-Seq_K562_Human0.98582279
118LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98568174
119SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98117287
120* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96991163
121TBX20_22080862_ChIP-Seq_HEART_Mouse0.96979456
122TBX20_22328084_ChIP-Seq_HEART_Mouse0.96979456
123CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94542728
124* GATA2_19941826_ChIP-Seq_K562_Human0.94068408
125KLF5_25053715_ChIP-Seq_YYC3_Human0.93127572
126MAF_26560356_Chip-Seq_TH1_Human0.92436219
127* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92405186
128BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92392453
129SALL1_21062744_ChIP-ChIP_HESCs_Human0.90860889
130AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90380054
131RNF2_18974828_ChIP-Seq_MESCs_Mouse0.90210230
132EZH2_18974828_ChIP-Seq_MESCs_Mouse0.90210230
133ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89283870
134FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.88585118
135SOX9_24532713_ChIP-Seq_HFSC_Mouse0.88398795
136RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88275289
137* FOXA2_19822575_ChIP-Seq_HepG2_Human0.87925769
138SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.87781548
139* GATA6_25053715_ChIP-Seq_YYC3_Human0.87070787
140TCF4_18268006_ChIP-ChIP_LS174T_Human0.85681273
141RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.85671087
142CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85583394
143* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85135707
144SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.84858803
145FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.84752576
146TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84518631
147* SOX2_21211035_ChIP-Seq_LN229_Gbm0.84003510
148SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83802916
149ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83021780
150E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.82883661
151SOX2_20726797_ChIP-Seq_SW620_Human0.82801851
152STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.82598610
153GATA3_26560356_Chip-Seq_TH2_Human0.80982925

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.91811944
2MP0004859_abnormal_synaptic_plasticity3.95662501
3MP0003303_peritoneal_inflammation3.22215811
4MP0003724_increased_susceptibility_to3.13465075
5MP0003300_gastrointestinal_ulcer3.07827981
6MP0001835_abnormal_antigen_presentation2.84843766
7MP0004185_abnormal_adipocyte_glucose2.81892774
8MP0005451_abnormal_body_composition2.73975217
9MP0004270_analgesia2.66392852
10MP0004130_abnormal_muscle_cell2.56807043
11MP0003763_abnormal_thymus_physiology2.47046788
12MP0005076_abnormal_cell_differentiation2.46746172
13MP0000685_abnormal_immune_system2.44188897
14MP0003705_abnormal_hypodermis_morpholog2.43217892
15MP0005671_abnormal_response_to2.38587030
16MP0000751_myopathy2.35163102
17MP0001800_abnormal_humoral_immune2.26505294
18MP0005000_abnormal_immune_tolerance2.26094410
19MP0005387_immune_system_phenotype2.21475456
20MP0001790_abnormal_immune_system2.21475456
21MP0002419_abnormal_innate_immunity2.18874718
22MP0010352_gastrointestinal_tract_polyps2.11942310
23MP0005464_abnormal_platelet_physiology2.06559946
24MP0005025_abnormal_response_to2.02498810
25MP0002909_abnormal_adrenal_gland1.98029367
26MP0009785_altered_susceptibility_to1.94854599
27MP0009780_abnormal_chondrocyte_physiolo1.94532118
28MP0003635_abnormal_synaptic_transmissio1.94389553
29MP0002723_abnormal_immune_serum1.94314631
30MP0002452_abnormal_antigen_presenting1.93926358
31MP0002420_abnormal_adaptive_immunity1.91141831
32MP0000747_muscle_weakness1.89872954
33MP0001819_abnormal_immune_cell1.88411823
34MP0000569_abnormal_digit_pigmentation1.88248588
35MP0006082_CNS_inflammation1.78574142
36MP0003329_amyloid_beta_deposits1.78239502
37MP0002009_preneoplasia1.77709484
38MP0008260_abnormal_autophagy1.73791054
39MP0000604_amyloidosis1.66824802
40MP0002148_abnormal_hypersensitivity_rea1.60956868
41MP0005167_abnormal_blood-brain_barrier1.60445250
42MP0002063_abnormal_learning/memory/cond1.59610011
43MP0004858_abnormal_nervous_system1.58671453
44MP0002398_abnormal_bone_marrow1.58140889
45MP0003045_fibrosis1.55723889
46MP0005666_abnormal_adipose_tissue1.54976838
47MP0002796_impaired_skin_barrier1.51351375
48MP0001533_abnormal_skeleton_physiology1.51317541
49MP0002877_abnormal_melanocyte_morpholog1.50360119
50MP0004484_altered_response_of1.50067671
51MP0003566_abnormal_cell_adhesion1.50033711
52MP0002166_altered_tumor_susceptibility1.49997919
53MP0002405_respiratory_system_inflammati1.45670272
54MP0000716_abnormal_immune_system1.44777919
55MP0004145_abnormal_muscle_electrophysio1.43246974
56MP0008961_abnormal_basal_metabolism1.41637687
57MP0000858_altered_metastatic_potential1.41062880
58MP0004087_abnormal_muscle_fiber1.37413686
59MP0005409_darkened_coat_color1.34528618
60MP0001845_abnormal_inflammatory_respons1.34206224
61MP0002998_abnormal_bone_remodeling1.33792868
62MP0005623_abnormal_meninges_morphology1.33697197
63MP0001851_eye_inflammation1.33410580
64MP0005058_abnormal_lysosome_morphology1.32227129
65MP0009046_muscle_twitch1.31735935
66MP0003075_altered_response_to1.31452516
67MP0004233_abnormal_muscle_weight1.31319287
68MP0010678_abnormal_skin_adnexa1.31201520
69MP0010307_abnormal_tumor_latency1.29145033
70MP0002064_seizures1.28045740
71MP0005166_decreased_susceptibility_to1.27604793
72MP0003656_abnormal_erythrocyte_physiolo1.26539276
73MP0001853_heart_inflammation1.26233104
74MP0009333_abnormal_splenocyte_physiolog1.25498682
75MP0003091_abnormal_cell_migration1.25376097
76MP0002332_abnormal_exercise_endurance1.25193371
77MP0003183_abnormal_peptide_metabolism1.23493472
78MP0003646_muscle_fatigue1.21672433
79MP0002722_abnormal_immune_system1.21498389
80MP0000703_abnormal_thymus_morphology1.21490783
81MP0008569_lethality_at_weaning1.20020561
82MP0000465_gastrointestinal_hemorrhage1.19951416
83MP0005310_abnormal_salivary_gland1.19074390
84MP0000689_abnormal_spleen_morphology1.18393326
85MP0005375_adipose_tissue_phenotype1.15871081
86MP0000733_abnormal_muscle_development1.14043194
87MP0000343_altered_response_to1.13612138
88MP0002429_abnormal_blood_cell1.12349318
89MP0003633_abnormal_nervous_system1.12323388
90MP0003880_abnormal_central_pattern1.12125331
91MP0003453_abnormal_keratinocyte_physiol1.11197181
92MP0009278_abnormal_bone_marrow1.10643294
93MP0004036_abnormal_muscle_relaxation1.09897290
94MP0004885_abnormal_endolymph1.09540056
95MP0000013_abnormal_adipose_tissue1.08229670
96MP0001873_stomach_inflammation1.07604799
97MP0004084_abnormal_cardiac_muscle1.07295360
98MP0002822_catalepsy1.05673147
99MP0003690_abnormal_glial_cell1.03953843
100MP0002396_abnormal_hematopoietic_system1.03784982
101MP0002106_abnormal_muscle_physiology1.02851128
102MP0002006_tumorigenesis1.01449539
103MP0004811_abnormal_neuron_physiology1.01227926
104MP0004381_abnormal_hair_follicle1.01082717
105MP0003191_abnormal_cellular_cholesterol0.98841672
106MP0009745_abnormal_behavioral_response0.98007922
107MP0004808_abnormal_hematopoietic_stem0.97509619
108MP0003172_abnormal_lysosome_physiology0.93561185
109MP0002269_muscular_atrophy0.93283459
110MP0003221_abnormal_cardiomyocyte_apopto0.93223691
111MP0003866_abnormal_defecation0.93175232
112MP0002837_dystrophic_cardiac_calcinosis0.92703014
113MP0002733_abnormal_thermal_nociception0.92145891
114MP0004510_myositis0.91593079
115MP0004883_abnormal_blood_vessel0.91155351
116MP0008469_abnormal_protein_level0.90172718
117MP0001970_abnormal_pain_threshold0.88704718
118MP0000749_muscle_degeneration0.88106848
119MP0002734_abnormal_mechanical_nocicepti0.87760049
120MP0001440_abnormal_grooming_behavior0.86428359
121MP0002971_abnormal_brown_adipose0.86369538
122MP0005620_abnormal_muscle_contractility0.84666447
123MP0010630_abnormal_cardiac_muscle0.84501501
124MP0004947_skin_inflammation0.83925563
125MP0001299_abnormal_eye_distance/0.83757462
126MP0003828_pulmonary_edema0.83115353
127MP0000759_abnormal_skeletal_muscle0.82924629
128MP0005386_behavior/neurological_phenoty0.82325208
129MP0004924_abnormal_behavior0.82325208
130MP0000003_abnormal_adipose_tissue0.81585321
131MP0001501_abnormal_sleep_pattern0.80093600
132MP0002089_abnormal_postnatal_growth/wei0.79680396
133MP0008874_decreased_physiological_sensi0.78818985
134MP0002896_abnormal_bone_mineralization0.78265339
135MP0002572_abnormal_emotion/affect_behav0.77792068
136MP0005164_abnormal_response_to0.76888564
137MP0004264_abnormal_extraembryonic_tissu0.76760666
138MP0001663_abnormal_digestive_system0.76580255
139MP0003448_altered_tumor_morphology0.75809218
140MP0010155_abnormal_intestine_physiology0.75315986
141MP0001348_abnormal_lacrimal_gland0.74978685
142MP0005187_abnormal_penis_morphology0.73519034
143MP0003283_abnormal_digestive_organ0.71756201
144MP0000750_abnormal_muscle_regeneration0.70813809
145MP0003631_nervous_system_phenotype0.70528712
146MP0000537_abnormal_urethra_morphology0.69080223
147MP0005330_cardiomyopathy0.68765271
148MP0008770_decreased_survivor_rate0.68288902
149MP0003436_decreased_susceptibility_to0.66582408
150MP0003634_abnormal_glial_cell0.65821462
151MP0000955_abnormal_spinal_cord0.65275891

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.81097847
2Recurrent bacterial skin infections (HP:0005406)3.63417241
3Recurrent abscess formation (HP:0002722)3.38268494
4Exercise-induced myalgia (HP:0003738)3.26263455
5Abnormality of macrophages (HP:0004311)3.24679419
6Hypoplastic ischia (HP:0003175)3.14274630
7Epiphyseal dysplasia (HP:0002656)3.12025607
8Spontaneous hematomas (HP:0007420)3.10614026
9T lymphocytopenia (HP:0005403)3.09184604
10Abnormality of T cell number (HP:0011839)2.97543693
11Myositis (HP:0100614)2.96020009
12Orchitis (HP:0100796)2.95838199
13Centrally nucleated skeletal muscle fibers (HP:0003687)2.90113267
14Exercise-induced muscle cramps (HP:0003710)2.88443837
15Difficulty running (HP:0009046)2.87617680
16Retrobulbar optic neuritis (HP:0100654)2.82739698
17Optic neuritis (HP:0100653)2.82739698
18Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.79565341
19Gingivitis (HP:0000230)2.79184284
20Hyporeflexia of lower limbs (HP:0002600)2.77580480
21Gastrointestinal infarctions (HP:0005244)2.74167843
22Termporal pattern (HP:0011008)2.72122096
23Insidious onset (HP:0003587)2.72122096
24Subacute progressive viral hepatitis (HP:0006572)2.69247341
25Abnormality of the ischium (HP:0003174)2.68133713
26Subaortic stenosis (HP:0001682)2.67725433
27Abnormality of the left ventricular outflow tract (HP:0011103)2.67725433
28Urinary urgency (HP:0000012)2.64474235
29Recurrent gram-negative bacterial infections (HP:0005420)2.62389383
30Mediastinal lymphadenopathy (HP:0100721)2.61512375
31Dysmetric saccades (HP:0000641)2.60630553
32Recurrent fungal infections (HP:0002841)2.57738153
33Muscle fiber inclusion bodies (HP:0100299)2.54948504
34Papilledema (HP:0001085)2.53688187
35Bundle branch block (HP:0011710)2.50027547
36Abnormal delayed hypersensitivity skin test (HP:0002963)2.48969707
37Flat acetabular roof (HP:0003180)2.48683652
38Frequent falls (HP:0002359)2.44592645
39Cellulitis (HP:0100658)2.43362012
40Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.43017567
41Muscle fiber splitting (HP:0003555)2.42353999
42Gingival bleeding (HP:0000225)2.42326988
43Meningitis (HP:0001287)2.42024492
44Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.41048248
45Visual hallucinations (HP:0002367)2.39393064
46Vasculitis (HP:0002633)2.39126869
47Ulnar bowing (HP:0003031)2.38775728
48Ulnar deviation of the wrist (HP:0003049)2.38492144
49Difficulty climbing stairs (HP:0003551)2.36401991
50Lower limb asymmetry (HP:0100559)2.36072861
51Recurrent skin infections (HP:0001581)2.35984171
52Chest pain (HP:0100749)2.35342644
53Cerebral aneurysm (HP:0004944)2.34874962
54Prolonged bleeding time (HP:0003010)2.34728374
55Increased IgE level (HP:0003212)2.34329714
56Annular pancreas (HP:0001734)2.33889330
57Cupped ribs (HP:0000887)2.33315439
58Recurrent viral infections (HP:0004429)2.31817377
59Supranuclear gaze palsy (HP:0000605)2.31369668
60Focal motor seizures (HP:0011153)2.30630617
61Metaphyseal cupping (HP:0003021)2.30506102
62Fatigue (HP:0012378)2.29268287
63Keratoconjunctivitis sicca (HP:0001097)2.28068354
64Chronic mucocutaneous candidiasis (HP:0002728)2.26797755
65Recurrent cutaneous fungal infections (HP:0011370)2.26797755
66Nemaline bodies (HP:0003798)2.21642544
67Urticaria (HP:0001025)2.21417495
68Pulmonary infiltrates (HP:0002113)2.20476654
69Inflammation of the large intestine (HP:0002037)2.18113765
70Arterial thrombosis (HP:0004420)2.17665863
71Chronic obstructive pulmonary disease (HP:0006510)2.17556738
72Obstructive lung disease (HP:0006536)2.17556738
73Achilles tendon contracture (HP:0001771)2.17445195
74Action tremor (HP:0002345)2.16123731
75Epistaxis (HP:0000421)2.14354062
76Pelvic girdle muscle weakness (HP:0003749)2.13420006
77Type 1 muscle fiber predominance (HP:0003803)2.12332340
78Milia (HP:0001056)2.12133788
79Distal lower limb muscle weakness (HP:0009053)2.12079959
80Slow saccadic eye movements (HP:0000514)2.11325334
81Autoimmune hemolytic anemia (HP:0001890)2.10322510
82Gastrointestinal inflammation (HP:0004386)2.10055636
83Shoulder girdle muscle weakness (HP:0003547)2.09736885
84Right ventricular cardiomyopathy (HP:0011663)2.07483224
85Encephalitis (HP:0002383)2.07094055
86Thick nail (HP:0001805)2.06918445
87Gastrointestinal stroma tumor (HP:0100723)2.06265739
88Pustule (HP:0200039)2.04993046
89Ventricular fibrillation (HP:0001663)2.04597627
90Abnormality of T cells (HP:0002843)2.02955427
91Distal lower limb amyotrophy (HP:0008944)2.02732544
92Myokymia (HP:0002411)2.02173531
93Abnormal tarsal ossification (HP:0008369)2.02006037
94Increased connective tissue (HP:0009025)2.00829255
95Keratoconjunctivitis (HP:0001096)2.00671927
96Macroorchidism (HP:0000053)1.98423162
97Focal seizures (HP:0007359)1.97946562
98Cerebral inclusion bodies (HP:0100314)1.97750201
99Urinary bladder sphincter dysfunction (HP:0002839)1.97584123
100Rhabdomyolysis (HP:0003201)1.94757855
101Osteomyelitis (HP:0002754)1.94543896
102Colitis (HP:0002583)1.93880973
103Abnormality of the hip-girdle musculature (HP:0001445)1.92428967
104Abnormality of the musculature of the pelvis (HP:0001469)1.92428967
105Abnormal platelet volume (HP:0011876)1.91388035
106Myopathic facies (HP:0002058)1.91074509
107Abnormality of the Achilles tendon (HP:0005109)1.90692355
108Chronic diarrhea (HP:0002028)1.89208492
109Increased CSF protein (HP:0002922)1.88061788
110Increased IgM level (HP:0003496)1.87820122
111Stomatitis (HP:0010280)1.87774529
112Irregular epiphyses (HP:0010582)1.86946796
113Hemoptysis (HP:0002105)1.86690318
114Elevated erythrocyte sedimentation rate (HP:0003565)1.85219517
115Resting tremor (HP:0002322)1.84654362
116Abnormality of oral frenula (HP:0000190)1.84558185
117Hamartoma of the eye (HP:0010568)1.84211833
118Onycholysis (HP:0001806)1.83529171
119Rapidly progressive (HP:0003678)1.83450292
120Abnormal foot bone ossification (HP:0010675)1.82711201
121Polycythemia (HP:0001901)1.82649922
122Absent frontal sinuses (HP:0002688)1.82118166
123Waddling gait (HP:0002515)1.80171586
124Abnormality of the endocardium (HP:0004306)1.78132952
125Ankyloglossia (HP:0010296)1.77508493
126Hematochezia (HP:0002573)1.76804079
127Atonic seizures (HP:0010819)1.76667765
128Upper limb amyotrophy (HP:0009129)1.74534285
129Distal upper limb amyotrophy (HP:0007149)1.74534285
130Asymmetric septal hypertrophy (HP:0001670)1.74271409
131Absence seizures (HP:0002121)1.73818123
132Lower limb amyotrophy (HP:0007210)1.73124394
133Periodontitis (HP:0000704)1.72621545
134Leukocytosis (HP:0001974)1.72507219
135Premature loss of primary teeth (HP:0006323)1.72088021
136Small epiphyses (HP:0010585)1.71352631
137Scapular winging (HP:0003691)1.70679459
138Pulmonary embolism (HP:0002204)1.70343896
139Distal arthrogryposis (HP:0005684)1.70157263
140Muscle hypertrophy of the lower extremities (HP:0008968)1.70055439
141Hemiplegia (HP:0002301)1.70016116
142Intention tremor (HP:0002080)1.69129308
143Disinhibition (HP:0000734)1.68954674
144Ankle clonus (HP:0011448)1.68366111
145Asymmetric growth (HP:0100555)1.68111603
146Sudden death (HP:0001699)1.67707679
147Granulocytopenia (HP:0001913)1.66849359
148Impaired vibration sensation in the lower limbs (HP:0002166)1.66259142
149Skin ulcer (HP:0200042)1.65651694
150Abnormality of binocular vision (HP:0011514)1.65460018
151Diplopia (HP:0000651)1.65460018
152Neurofibrillary tangles (HP:0002185)1.64971131
153EMG: myopathic abnormalities (HP:0003458)1.63645466
154Viral hepatitis (HP:0006562)1.63092416
155Proximal amyotrophy (HP:0007126)1.62900708
156Alopecia of scalp (HP:0002293)1.62529800
157Limb-girdle muscle atrophy (HP:0003797)1.61712608
158Calf muscle hypertrophy (HP:0008981)1.60934983
159Truncal ataxia (HP:0002078)1.60146180
160Apathy (HP:0000741)1.60083893
161Increased variability in muscle fiber diameter (HP:0003557)1.59317016
162Increased density of long bones (HP:0006392)1.59009005
163Mutism (HP:0002300)1.58024477
164Exostoses (HP:0100777)1.57700404
165Muscle stiffness (HP:0003552)1.57432807
166Neck muscle weakness (HP:0000467)1.57166227
167Hand muscle atrophy (HP:0009130)1.56773960
168Round ear (HP:0100830)1.54497793
169Conjunctival hamartoma (HP:0100780)1.54248207
170Hypercortisolism (HP:0001578)1.54103248
171Abnormality of skeletal muscle fiber size (HP:0012084)1.53304049

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.42524536
2PRPF4B3.37626421
3TRIB33.12549369
4KSR22.54618407
5MAP3K142.47902018
6TTN2.30743137
7DDR22.24612885
8MAP3K22.21992984
9TYRO32.20920241
10MAP4K12.14905783
11MAP2K32.13390855
12FRK1.89791824
13SCYL21.85341279
14TYK21.83130438
15LMTK21.83114498
16PKN21.82997813
17BLK1.74879273
18RIPK11.70635932
19PHKG21.63852172
20PHKG11.63852172
21PDGFRA1.60141238
22ZAP701.59048417
23ICK1.53253520
24ALK1.51972173
25DMPK1.47773224
26RIPK41.46843222
27TXK1.46632291
28MAP3K41.45673972
29JAK31.44319436
30FGR1.43615713
31ERN11.42056374
32NTRK31.39565327
33PIK3CG1.37970839
34RET1.37406097
35TAOK11.36012902
36IRAK41.35393861
37MAP2K41.32775220
38BTK1.31787429
39MAP3K61.30482925
40MARK11.28626114
41SYK1.28357450
42KSR11.24547458
43BMX1.24041102
44PAK61.24013588
45PRKCH1.20707446
46MAPK121.20103483
47YES11.18658771
48NEK91.18541345
49CAMKK11.18410240
50PTK61.15772498
51HCK1.12146673
52STK241.09839328
53FGFR41.09587151
54FGFR31.08545354
55MAP3K31.07904585
56PDGFRB1.07414694
57EPHB11.06857899
58MST1R1.06823129
59LATS21.05809104
60EEF2K1.04874390
61PRKD31.04172546
62STK381.03554557
63CAMKK21.02593375
64PDK11.00301604
65MST40.99211716
66CDK120.98076022
67MAP3K110.96943749
68NEK10.96347110
69MINK10.96239051
70CSF1R0.95827278
71BMPR20.94818341
72IKBKE0.94058386
73TGFBR20.93741163
74TRPM70.93505118
75MOS0.93309670
76SGK30.93292584
77CSK0.93271528
78LATS10.92539115
79FGFR20.91085608
80PDPK10.88027658
81EPHA40.87386032
82DAPK20.86908729
83NTRK10.86485364
84TBK10.85314885
85SGK20.84015565
86CDK50.83183401
87ITK0.82612123
88MARK20.82218722
89SIK20.81484370
90JAK20.80951993
91CDK60.80364810
92LCK0.79648331
93STK110.79099960
94MAP3K70.76300164
95FES0.74731734
96JAK10.74615575
97MAP3K100.74465857
98STK100.73496576
99GRK60.73438368
100RAF10.72117146
101NTRK20.71568551
102CAMK1G0.71269485
103NME10.70225615
104LYN0.69193188
105GSK3A0.68119570
106TEC0.68117623
107STK30.66566909
108FER0.66391853
109TAOK30.66186365
110LRRK20.65564576
111ARAF0.65500534
112DAPK10.65247412
113SGK10.63586758
114MAP3K10.63323464
115SMG10.63119376
116CAMK1D0.61941926
117MATK0.61801644
118TAOK20.61203544
119PDK30.60258026
120PDK40.60258026
121PRKAA10.58068183
122MAPK110.57536960
123MAPK70.57414873
124RPS6KA20.56551621
125CSNK1G20.56324517
126CDC42BPA0.55996215
127EGFR0.55927724
128PRKD10.55182847
129PINK10.54237109
130ACVR1B0.53765198
131WNK10.49565652
132ERBB30.49229562
133MAP2K10.48766997
134PRKG20.48755207
135PDK20.47102678
136PRKCQ0.46943970
137DYRK1B0.46491561
138OBSCN0.45327140
139STK390.44756707
140RPS6KC10.42989081
141RPS6KL10.42989081
142PAK30.42911008
143MARK30.42812957
144SGK4940.42614998
145SGK2230.42614998
146MAP3K130.42575481
147MAP3K50.42544970
148IRAK10.42246746
149MAPK100.41541571
150FYN0.41172342

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.10924406
2Dorso-ventral axis formation_Homo sapiens_hsa043201.85094616
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77513514
4Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.75412201
5Long-term potentiation_Homo sapiens_hsa047201.71085508
6Toll-like receptor signaling pathway_Homo sapiens_hsa046201.66240765
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.60959738
8Gastric acid secretion_Homo sapiens_hsa049711.59833805
9* mTOR signaling pathway_Homo sapiens_hsa041501.57860107
10Acute myeloid leukemia_Homo sapiens_hsa052211.54636846
11VEGF signaling pathway_Homo sapiens_hsa043701.51720661
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49454151
13Fatty acid biosynthesis_Homo sapiens_hsa000611.49314524
14Nitrogen metabolism_Homo sapiens_hsa009101.47782731
15Salivary secretion_Homo sapiens_hsa049701.44419492
16Renin secretion_Homo sapiens_hsa049241.43967989
17Measles_Homo sapiens_hsa051621.42727511
18Toxoplasmosis_Homo sapiens_hsa051451.40117609
19Oxytocin signaling pathway_Homo sapiens_hsa049211.36468616
20Staphylococcus aureus infection_Homo sapiens_hsa051501.36072016
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.35474770
22GnRH signaling pathway_Homo sapiens_hsa049121.34769299
23Allograft rejection_Homo sapiens_hsa053301.33347548
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33211425
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33055504
26Olfactory transduction_Homo sapiens_hsa047401.32778879
27Glioma_Homo sapiens_hsa052141.27496839
28Graft-versus-host disease_Homo sapiens_hsa053321.27221074
29Autoimmune thyroid disease_Homo sapiens_hsa053201.25781494
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24712728
31Synaptic vesicle cycle_Homo sapiens_hsa047211.22923868
32Estrogen signaling pathway_Homo sapiens_hsa049151.21466925
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20428812
34Hematopoietic cell lineage_Homo sapiens_hsa046401.19273245
35Renal cell carcinoma_Homo sapiens_hsa052111.17864889
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17642498
37TNF signaling pathway_Homo sapiens_hsa046681.17226764
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.16053344
39Type II diabetes mellitus_Homo sapiens_hsa049301.15358898
40Influenza A_Homo sapiens_hsa051641.14557741
41Dopaminergic synapse_Homo sapiens_hsa047281.14103520
42Long-term depression_Homo sapiens_hsa047301.13652371
43Primary immunodeficiency_Homo sapiens_hsa053401.12148401
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10870110
45Malaria_Homo sapiens_hsa051441.10478878
46Gap junction_Homo sapiens_hsa045401.09576167
47Hepatitis B_Homo sapiens_hsa051611.09330838
48Carbohydrate digestion and absorption_Homo sapiens_hsa049731.08975284
49Endometrial cancer_Homo sapiens_hsa052131.08742865
50Cholinergic synapse_Homo sapiens_hsa047251.07804715
51Circadian entrainment_Homo sapiens_hsa047131.06110174
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05260103
53Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05110012
54Hepatitis C_Homo sapiens_hsa051601.04018576
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03948365
56ErbB signaling pathway_Homo sapiens_hsa040121.03777928
57Amphetamine addiction_Homo sapiens_hsa050311.03280877
58Focal adhesion_Homo sapiens_hsa045101.02383343
59Non-small cell lung cancer_Homo sapiens_hsa052231.01916714
60Choline metabolism in cancer_Homo sapiens_hsa052311.01519674
61Adherens junction_Homo sapiens_hsa045201.00781916
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99631744
63Antigen processing and presentation_Homo sapiens_hsa046120.99349012
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.99056692
65Insulin signaling pathway_Homo sapiens_hsa049100.97802373
66Endocytosis_Homo sapiens_hsa041440.97698310
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96908580
68Chronic myeloid leukemia_Homo sapiens_hsa052200.96192360
69GABAergic synapse_Homo sapiens_hsa047270.96002006
70Insulin resistance_Homo sapiens_hsa049310.95293829
71Apoptosis_Homo sapiens_hsa042100.95268785
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95187300
73Proteoglycans in cancer_Homo sapiens_hsa052050.94396958
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94364881
75Dilated cardiomyopathy_Homo sapiens_hsa054140.93886320
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93656567
77Shigellosis_Homo sapiens_hsa051310.93054338
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92292722
79Platelet activation_Homo sapiens_hsa046110.91608080
80Glutamatergic synapse_Homo sapiens_hsa047240.90544320
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.90450325
82Mineral absorption_Homo sapiens_hsa049780.89829057
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88934223
84Tight junction_Homo sapiens_hsa045300.88678292
85Thyroid cancer_Homo sapiens_hsa052160.88630123
86T cell receptor signaling pathway_Homo sapiens_hsa046600.88350790
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88331511
88Pancreatic cancer_Homo sapiens_hsa052120.88153234
89Insulin secretion_Homo sapiens_hsa049110.87681417
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.85023645
91Osteoclast differentiation_Homo sapiens_hsa043800.84806791
92Colorectal cancer_Homo sapiens_hsa052100.84449293
93MAPK signaling pathway_Homo sapiens_hsa040100.83847693
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83324779
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82796462
96Viral myocarditis_Homo sapiens_hsa054160.81832928
97B cell receptor signaling pathway_Homo sapiens_hsa046620.81732491
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81042153
99Morphine addiction_Homo sapiens_hsa050320.81004412
100Prolactin signaling pathway_Homo sapiens_hsa049170.80399503
101Phagosome_Homo sapiens_hsa041450.80051794
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.80035243
103Type I diabetes mellitus_Homo sapiens_hsa049400.79939643
104Herpes simplex infection_Homo sapiens_hsa051680.79626620
105Salmonella infection_Homo sapiens_hsa051320.75866058
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75568003
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.74616338
108cAMP signaling pathway_Homo sapiens_hsa040240.74371473
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.74340310
110Legionellosis_Homo sapiens_hsa051340.73227473
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.73010559
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72883178
113Glucagon signaling pathway_Homo sapiens_hsa049220.72813530
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72627659
115* AMPK signaling pathway_Homo sapiens_hsa041520.71746695
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.71527298
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71522523
118Thyroid hormone synthesis_Homo sapiens_hsa049180.71301016
119Amoebiasis_Homo sapiens_hsa051460.71237215
120Chemokine signaling pathway_Homo sapiens_hsa040620.70372268
121Small cell lung cancer_Homo sapiens_hsa052220.70152490
122FoxO signaling pathway_Homo sapiens_hsa040680.68982311
123Inositol phosphate metabolism_Homo sapiens_hsa005620.67661442
124Pancreatic secretion_Homo sapiens_hsa049720.67507609
125Oocyte meiosis_Homo sapiens_hsa041140.67246548
126Circadian rhythm_Homo sapiens_hsa047100.67045909
127Pertussis_Homo sapiens_hsa051330.66768750
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66679939
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65860347
130Melanogenesis_Homo sapiens_hsa049160.64020525
131Axon guidance_Homo sapiens_hsa043600.64018119
132Nicotine addiction_Homo sapiens_hsa050330.62509722
133Rap1 signaling pathway_Homo sapiens_hsa040150.62112597
134HIF-1 signaling pathway_Homo sapiens_hsa040660.61565722
135Prostate cancer_Homo sapiens_hsa052150.61423624
136Viral carcinogenesis_Homo sapiens_hsa052030.61059066
137Tuberculosis_Homo sapiens_hsa051520.59968438
138Asthma_Homo sapiens_hsa053100.57745557
139Bladder cancer_Homo sapiens_hsa052190.57547470

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