CAB39L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.80220017
2L-phenylalanine catabolic process (GO:0006559)5.80220017
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.77811231
4L-phenylalanine metabolic process (GO:0006558)5.77811231
5aromatic amino acid family catabolic process (GO:0009074)5.34356932
6synaptic vesicle maturation (GO:0016188)5.10143694
7indole-containing compound catabolic process (GO:0042436)4.99613835
8indolalkylamine catabolic process (GO:0046218)4.99613835
9tryptophan catabolic process (GO:0006569)4.99613835
10glutamate secretion (GO:0014047)4.93202466
11synaptic vesicle exocytosis (GO:0016079)4.88953777
12tryptophan metabolic process (GO:0006568)4.82741437
13kynurenine metabolic process (GO:0070189)4.82065695
14cysteine metabolic process (GO:0006534)4.77884879
15alpha-linolenic acid metabolic process (GO:0036109)4.72835147
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.70979854
17urea cycle (GO:0000050)4.65007253
18urea metabolic process (GO:0019627)4.65007253
19sulfur amino acid catabolic process (GO:0000098)4.64314019
20bile acid biosynthetic process (GO:0006699)4.50497927
21glyoxylate metabolic process (GO:0046487)4.43135362
22complement activation, alternative pathway (GO:0006957)4.34089339
23high-density lipoprotein particle remodeling (GO:0034375)4.33077054
24regulation of short-term neuronal synaptic plasticity (GO:0048172)4.31140601
25regulation of protein activation cascade (GO:2000257)4.30996728
26valine metabolic process (GO:0006573)4.29796557
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.28644209
28synaptic vesicle docking involved in exocytosis (GO:0016081)4.25859779
29nitrogen cycle metabolic process (GO:0071941)4.25350894
30regulation of synaptic vesicle exocytosis (GO:2000300)4.23774724
31serine family amino acid catabolic process (GO:0009071)4.19745455
32lysine catabolic process (GO:0006554)4.18575728
33lysine metabolic process (GO:0006553)4.18575728
34amino-acid betaine metabolic process (GO:0006577)4.18526360
35gamma-aminobutyric acid transport (GO:0015812)4.17956553
36protein carboxylation (GO:0018214)4.13837332
37peptidyl-glutamic acid carboxylation (GO:0017187)4.13837332
38regulation of complement activation (GO:0030449)4.09887134
39aldehyde catabolic process (GO:0046185)4.08729949
40negative regulation of fibrinolysis (GO:0051918)4.06164544
41homocysteine metabolic process (GO:0050667)4.05408822
42aromatic amino acid family metabolic process (GO:0009072)4.00169597
43sodium ion export (GO:0071436)3.91427635
44ethanol oxidation (GO:0006069)3.88148270
45reverse cholesterol transport (GO:0043691)3.87846581
46cellular glucuronidation (GO:0052695)3.87802913
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.86765353
48neurotransmitter secretion (GO:0007269)3.85714624
49regulation of triglyceride catabolic process (GO:0010896)3.85283407
50cellular potassium ion homeostasis (GO:0030007)3.84164451
51tyrosine metabolic process (GO:0006570)3.82584605
52positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.81433435
53bile acid metabolic process (GO:0008206)3.78876255
54positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.76919460
55glycine metabolic process (GO:0006544)3.74778416
56vocalization behavior (GO:0071625)3.73680520
57plasma lipoprotein particle remodeling (GO:0034369)3.73126685
58protein-lipid complex remodeling (GO:0034368)3.73126685
59macromolecular complex remodeling (GO:0034367)3.73126685
60regulation of fibrinolysis (GO:0051917)3.72107435
61alpha-amino acid catabolic process (GO:1901606)3.71660475
62negative regulation of cholesterol transport (GO:0032375)3.66464988
63negative regulation of sterol transport (GO:0032372)3.66464988
64regulation of cholesterol esterification (GO:0010872)3.64374908
65serine family amino acid metabolic process (GO:0009069)3.61124067
66L-amino acid import (GO:0043092)3.61060813
67benzene-containing compound metabolic process (GO:0042537)3.60400099
68glucuronate metabolic process (GO:0019585)3.58542611
69uronic acid metabolic process (GO:0006063)3.58542611
70neuron cell-cell adhesion (GO:0007158)3.56766802
71amino acid import (GO:0043090)3.56147795
72phospholipid efflux (GO:0033700)3.55148290
73regulation of synaptic vesicle transport (GO:1902803)3.54885721
74pyrimidine nucleobase catabolic process (GO:0006208)3.52640924
75cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.48780972
76plasma lipoprotein particle clearance (GO:0034381)3.48532146
77indolalkylamine metabolic process (GO:0006586)3.47009108
78cellular amino acid catabolic process (GO:0009063)3.46713367
79serine family amino acid biosynthetic process (GO:0009070)3.43695869
80drug catabolic process (GO:0042737)3.43514700
81bile acid and bile salt transport (GO:0015721)3.41577220
82regulation of synapse structural plasticity (GO:0051823)3.37276713
83acylglycerol homeostasis (GO:0055090)3.32145733
84triglyceride homeostasis (GO:0070328)3.32145733
852-oxoglutarate metabolic process (GO:0006103)3.31775586
86ionotropic glutamate receptor signaling pathway (GO:0035235)3.31639517
87urate metabolic process (GO:0046415)3.28676134
88pyridine nucleotide biosynthetic process (GO:0019363)3.27361801
89nicotinamide nucleotide biosynthetic process (GO:0019359)3.27361801
90carnitine metabolic process (GO:0009437)3.27161645
91complement activation, classical pathway (GO:0006958)3.26191169
92amine catabolic process (GO:0009310)3.26145190
93cellular biogenic amine catabolic process (GO:0042402)3.26145190
94arginine metabolic process (GO:0006525)3.23632481
95cholesterol efflux (GO:0033344)3.21857531
96fatty acid oxidation (GO:0019395)3.21727267
97folic acid metabolic process (GO:0046655)3.21305375
98cellular modified amino acid catabolic process (GO:0042219)3.20450920
99carboxylic acid catabolic process (GO:0046395)3.20361663
100organic acid catabolic process (GO:0016054)3.20361663
101fatty acid beta-oxidation (GO:0006635)3.19697305
102complement activation (GO:0006956)3.19566617
103xenobiotic catabolic process (GO:0042178)3.19133512
104NAD biosynthetic process (GO:0009435)3.18114743
105imidazole-containing compound metabolic process (GO:0052803)3.16625747
106lipid oxidation (GO:0034440)3.16432475
107cell communication by electrical coupling (GO:0010644)3.14401001
108oxaloacetate metabolic process (GO:0006107)3.13037026
109axonal fasciculation (GO:0007413)3.12932727
110neuronal ion channel clustering (GO:0045161)3.12629208
111detection of calcium ion (GO:0005513)3.11610510
112cofactor catabolic process (GO:0051187)3.10672961
113low-density lipoprotein particle remodeling (GO:0034374)3.10141066
114monocarboxylic acid catabolic process (GO:0072329)3.08989622
115pantothenate metabolic process (GO:0015939)3.08980716
116negative regulation of protein activation cascade (GO:2000258)3.08747630
117cerebellar granule cell differentiation (GO:0021707)3.08145238
118short-chain fatty acid metabolic process (GO:0046459)3.06636821
119negative regulation of synaptic transmission, GABAergic (GO:0032229)3.06380057
120neuron recognition (GO:0008038)3.06075622
121S-adenosylmethionine metabolic process (GO:0046500)3.05181088
122fructose metabolic process (GO:0006000)3.04611617
123regulation of neuronal synaptic plasticity (GO:0048168)3.04246413
124synaptic transmission, glutamatergic (GO:0035249)3.03858215
125fatty acid catabolic process (GO:0009062)3.02582730
126dendritic spine organization (GO:0097061)3.02547016
127acute-phase response (GO:0006953)3.01985711
128folic acid transport (GO:0015884)3.01578183
129plasma lipoprotein particle assembly (GO:0034377)3.00852938
130coenzyme catabolic process (GO:0009109)3.00750220
131response to nitrosative stress (GO:0051409)3.00708272
132dendritic spine morphogenesis (GO:0060997)3.00095199
133fibrinolysis (GO:0042730)2.99865381
134presynaptic membrane organization (GO:0097090)2.99569647
135postsynaptic membrane organization (GO:0001941)2.99095508
136presynaptic membrane assembly (GO:0097105)2.98752718
137locomotory exploration behavior (GO:0035641)2.97473489
138regulation of neurotransmitter secretion (GO:0046928)2.97236716
139protein localization to synapse (GO:0035418)2.96590595
140nucleobase catabolic process (GO:0046113)2.95591489
141glycine transport (GO:0015816)2.94197858
142neurotransmitter transport (GO:0006836)2.94191178
143cellular sodium ion homeostasis (GO:0006883)2.93942491
144layer formation in cerebral cortex (GO:0021819)2.90903204
145regulation of neurotransmitter levels (GO:0001505)2.88745399
146neuron-neuron synaptic transmission (GO:0007270)2.88118840
147regulation of dendritic spine morphogenesis (GO:0061001)2.88047760
148neurotransmitter-gated ion channel clustering (GO:0072578)2.86755899
149positive regulation of dendritic spine development (GO:0060999)2.85639037
150glutamate receptor signaling pathway (GO:0007215)2.80440211
151regulation of dendritic spine development (GO:0060998)2.78916658
152cell communication involved in cardiac conduction (GO:0086065)2.78876390
153regulation of vesicle fusion (GO:0031338)2.78689801
154neurofilament cytoskeleton organization (GO:0060052)2.72670680
155regulation of neurotransmitter transport (GO:0051588)2.69444652
156positive regulation of membrane potential (GO:0045838)2.67554169
157synaptic vesicle endocytosis (GO:0048488)2.63880269
158regulation of excitatory postsynaptic membrane potential (GO:0060079)2.61951669
159potassium ion homeostasis (GO:0055075)2.61211767
160regulation of long-term neuronal synaptic plasticity (GO:0048169)2.61112748
161positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.60984726
162regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.59825550
163regulation of synaptic plasticity (GO:0048167)2.59795562
164cell migration in hindbrain (GO:0021535)2.59760038
165auditory behavior (GO:0031223)2.59246700
166negative regulation of dendrite development (GO:2000171)2.58943286
167regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.58403877
168exploration behavior (GO:0035640)2.58061505
169synapse assembly (GO:0007416)2.57733682
170positive regulation of synapse maturation (GO:0090129)2.57262774
171apical protein localization (GO:0045176)2.55992564
172neuronal action potential propagation (GO:0019227)2.55796603
173regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.55595345
174regulation of ARF protein signal transduction (GO:0032012)2.54552303
175suckling behavior (GO:0001967)2.53148075
176regulation of postsynaptic membrane potential (GO:0060078)2.53079035
177establishment of mitochondrion localization (GO:0051654)2.51345937
178regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.50706674
179vesicle transport along microtubule (GO:0047496)2.50623790
180regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.48131968
181regulation of cell communication by electrical coupling (GO:0010649)2.46887322
182synaptic vesicle transport (GO:0048489)2.45660702
183establishment of synaptic vesicle localization (GO:0097480)2.45660702
184regulation of clathrin-mediated endocytosis (GO:2000369)2.45303317
185central nervous system projection neuron axonogenesis (GO:0021952)2.45169903
186membrane depolarization during action potential (GO:0086010)2.44508286
187regulation of voltage-gated calcium channel activity (GO:1901385)2.43739704
188proline transport (GO:0015824)2.42629959
189regulation of glutamate receptor signaling pathway (GO:1900449)2.42374823
190negative regulation of dendrite morphogenesis (GO:0050774)2.42076421
191short-term memory (GO:0007614)2.40938338
192glycosphingolipid biosynthetic process (GO:0006688)2.40456241
193long-term synaptic potentiation (GO:0060291)2.40267646
194establishment of vesicle localization (GO:0051650)2.37407334
195calcium ion-dependent exocytosis (GO:0017156)2.36610789
196neuromuscular process controlling balance (GO:0050885)2.35288906
197organelle transport along microtubule (GO:0072384)2.34112623
198signal release (GO:0023061)2.33369730
199regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.31353774
200clathrin coat assembly (GO:0048268)2.31054489

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.34310071
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.75714225
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.23416973
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.02162317
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.54486298
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.31889351
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.11660158
8EZH2_22144423_ChIP-Seq_EOC_Human3.58666002
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.46121056
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.40938618
11IRF8_22096565_ChIP-ChIP_GC-B_Human3.03782437
12GBX2_23144817_ChIP-Seq_PC3_Human2.99379487
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.82725376
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.50531502
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.36408361
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.25340893
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15807018
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.14434990
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.11812986
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10197990
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08140536
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.07647731
23JARID2_20064375_ChIP-Seq_MESCs_Mouse2.07465123
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.07035478
25CDX2_19796622_ChIP-Seq_MESCs_Mouse2.05749971
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.02291398
27REST_21632747_ChIP-Seq_MESCs_Mouse2.00936756
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.98787480
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.98053412
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.92064502
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.91911119
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.91911119
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90517823
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.90303067
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.89006784
36GATA1_22025678_ChIP-Seq_K562_Human1.88374833
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87637782
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.86861130
39DROSHA_22980978_ChIP-Seq_HELA_Human1.84655803
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84493301
41TAF15_26573619_Chip-Seq_HEK293_Human1.84028425
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.83704255
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79779972
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.74086339
45IGF1R_20145208_ChIP-Seq_DFB_Human1.72878299
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.71396025
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70287668
48EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.70284458
49RARB_27405468_Chip-Seq_BRAIN_Mouse1.67479362
50SMAD4_21799915_ChIP-Seq_A2780_Human1.67474842
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66125576
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65670637
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.64984321
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63523520
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63041982
56REST_18959480_ChIP-ChIP_MESCs_Mouse1.62755291
57* IRF8_21731497_ChIP-ChIP_J774_Mouse1.61981912
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61343976
59AR_21572438_ChIP-Seq_LNCaP_Human1.58015794
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57794687
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57458986
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54260350
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52951281
64CLOCK_20551151_ChIP-Seq_293T_Human1.48223084
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47312140
66* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45445320
67EP300_21415370_ChIP-Seq_HL-1_Mouse1.44380042
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41529752
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40339190
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37985158
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.37945249
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37455335
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33214967
74AR_25329375_ChIP-Seq_VCAP_Human1.33019137
75TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.32086524
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30008102
77RNF2_27304074_Chip-Seq_NSC_Mouse1.29193322
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28884272
79NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26714829
80NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26714829
81AR_21909140_ChIP-Seq_LNCAP_Human1.26516976
82CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26420518
83RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26179630
84P300_19829295_ChIP-Seq_ESCs_Human1.25637246
85ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24421653
86MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23648527
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23441869
88TRIM28_21343339_ChIP-Seq_HEK293_Human1.22791029
89RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22473535
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21572509
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21504908
92MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21487712
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20749593
94* SRF_21415370_ChIP-Seq_HL-1_Mouse1.20364434
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.19322217
96STAT3_23295773_ChIP-Seq_U87_Human1.18304191
97NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17928987
98RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17702399
99SOX2_21211035_ChIP-Seq_LN229_Gbm1.17518573
100GABP_17652178_ChIP-ChIP_JURKAT_Human1.17272246
101AHR_22903824_ChIP-Seq_MCF-7_Human1.17224599
102TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16948763
103SMAD_19615063_ChIP-ChIP_OVARY_Human1.15903978
104YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14142241
105RING1B_27294783_Chip-Seq_ESCs_Mouse1.14051097
106ARNT_22903824_ChIP-Seq_MCF-7_Human1.13511416
107WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13219483
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12959504
109KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.12779167
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12472716
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11758171
112ZNF263_19887448_ChIP-Seq_K562_Human1.11520207
113LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11146902
114SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10892569
115PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09892319
116Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09831375
117TCF4_23295773_ChIP-Seq_U87_Human1.08366624
118TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07855741
119GATA4_25053715_ChIP-Seq_YYC3_Human1.05311799
120AR_19668381_ChIP-Seq_PC3_Human1.04234923
121BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04100562
122STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03631285
123RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02934013
124NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.01725440
125UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01647204
126TAL1_26923725_Chip-Seq_HPCs_Mouse1.00915633
127RING1B_27294783_Chip-Seq_NPCs_Mouse1.00652949
128TP53_18474530_ChIP-ChIP_U2OS_Human1.00647969
129PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00069229
130STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99849842
131STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99035870
132EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98790967
133* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98704845
134IRF8_27001747_Chip-Seq_BMDM_Mouse0.98540582
135POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98452043
136TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98452043
137BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98401106
138KDM2B_26808549_Chip-Seq_REH_Human0.97693317
139P53_22387025_ChIP-Seq_ESCs_Mouse0.97688462
140JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.97402464
141* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97309597
142SMAD4_21741376_ChIP-Seq_HESCs_Human0.97298251
143DCP1A_22483619_ChIP-Seq_HELA_Human0.97155609
144RUNX2_22187159_ChIP-Seq_PCA_Human0.97001678
145FUS_26573619_Chip-Seq_HEK293_Human0.96201650
146* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.95649388
147* HNF4A_19822575_ChIP-Seq_HepG2_Human0.95550775
148GATA1_26923725_Chip-Seq_HPCs_Mouse0.94851228
149CMYC_18555785_Chip-Seq_ESCs_Mouse0.94800708
150EST1_17652178_ChIP-ChIP_JURKAT_Human0.94265489
151CBP_20019798_ChIP-Seq_JUKART_Human0.93800729
152CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93546966
153FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93335535
154SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92814390
155E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92791792
156SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91460732
157FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88044113
158CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85210915
159SALL4_18804426_ChIP-ChIP_XEN_Mouse0.84799330
160KAP1_22055183_ChIP-Seq_ESCs_Mouse0.84612976
161SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.83666806
162RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83039786
163CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82205581
164CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82005502
165NELFA_20434984_ChIP-Seq_ESCs_Mouse0.81283741
166RXRA_24833708_ChIP-Seq_LIVER_Mouse0.80981832
167HTT_18923047_ChIP-ChIP_STHdh_Human0.80844350
168HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80631508
169* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78680958
170FOXA2_19822575_ChIP-Seq_HepG2_Human0.78225250
171GATA2_22383799_ChIP-Seq_G1ME_Mouse0.77204956
172CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76612558
173FOXP3_21729870_ChIP-Seq_TREG_Human0.76172145
174BRD4_27068464_Chip-Seq_AML-cells_Mouse0.75757635
175FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.75595749
176CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75270501
177MYC_18358816_ChIP-ChIP_MESCs_Mouse0.75214855
178GATA3_24758297_ChIP-Seq_MCF-7_Human0.75154505
179MYB_26560356_Chip-Seq_TH1_Human0.75094530
180ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.74126058
181MYB_26560356_Chip-Seq_TH2_Human0.73167233
182ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.72575451
183PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.72570090
184ERG_20517297_ChIP-Seq_VCAP_Human0.72544903
185GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.71661539
186* ETS1_20019798_ChIP-Seq_JURKAT_Human0.70961330
187* SOX2_20726797_ChIP-Seq_SW620_Human0.70764420
188MYC_18555785_ChIP-Seq_MESCs_Mouse0.70667645
189* VDR_23849224_ChIP-Seq_CD4+_Human0.70559799
190* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.70123337
191* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.69973784
192ESR1_15608294_ChIP-ChIP_MCF-7_Human0.69135771
193ESR1_21235772_ChIP-Seq_MCF-7_Human0.68584912
194GABP_19822575_ChIP-Seq_HepG2_Human0.67722904
195GATA3_26560356_Chip-Seq_TH2_Human0.67518418
196ESR1_20079471_ChIP-ChIP_T-47D_Human0.67126743
197SPI1_23547873_ChIP-Seq_NB4_Human0.66668282
198TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.64935806
199AR_20517297_ChIP-Seq_VCAP_Human0.64839164
200GATA1_22383799_ChIP-Seq_G1ME_Mouse0.64290032

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.47661777
2MP0005360_urolithiasis5.40070431
3MP0004859_abnormal_synaptic_plasticity4.73414912
4MP0005085_abnormal_gallbladder_physiolo4.70652543
5MP0005365_abnormal_bile_salt4.48170980
6MP0003806_abnormal_nucleotide_metabolis4.27367352
7MP0008875_abnormal_xenobiotic_pharmacok4.01998560
8MP0004270_analgesia3.58121478
9MP0003880_abnormal_central_pattern3.54625930
10MP0005423_abnormal_somatic_nervous3.03517018
11MP0010329_abnormal_lipoprotein_level2.94680712
12MP0003011_delayed_dark_adaptation2.81092732
13MP0003635_abnormal_synaptic_transmissio2.80037395
14MP0003252_abnormal_bile_duct2.76958231
15MP0003186_abnormal_redox_activity2.74275870
16MP0004019_abnormal_vitamin_homeostasis2.64986748
17MP0009840_abnormal_foam_cell2.63541853
18MP0005332_abnormal_amino_acid2.55219595
19MP0002822_catalepsy2.46290682
20MP0002064_seizures2.45926050
21MP0005083_abnormal_biliary_tract2.41646248
22MP0009046_muscle_twitch2.35214068
23MP0002063_abnormal_learning/memory/cond2.34691404
24MP0002272_abnormal_nervous_system2.31185741
25MP0002734_abnormal_mechanical_nocicepti2.29996148
26MP0003195_calcinosis2.28899382
27MP0001486_abnormal_startle_reflex2.26667378
28MP0001764_abnormal_homeostasis2.20879984
29MP0003191_abnormal_cellular_cholesterol2.19777447
30MP0009745_abnormal_behavioral_response2.16814179
31MP0009780_abnormal_chondrocyte_physiolo2.16402216
32MP0002735_abnormal_chemical_nociception2.06274507
33MP0000778_abnormal_nervous_system2.02577778
34MP0000609_abnormal_liver_physiology1.97723523
35MP0001984_abnormal_olfaction1.95551607
36MP0002572_abnormal_emotion/affect_behav1.93862544
37MP0001666_abnormal_nutrient_absorption1.90238852
38MP0005319_abnormal_enzyme/_coenzyme1.89790120
39MP0000751_myopathy1.89656694
40MP0001968_abnormal_touch/_nociception1.86480679
41MP0003656_abnormal_erythrocyte_physiolo1.86252631
42MP0002138_abnormal_hepatobiliary_system1.81002874
43MP0003329_amyloid_beta_deposits1.77794067
44MP0002653_abnormal_ependyma_morphology1.77670717
45MP0010386_abnormal_urinary_bladder1.72621973
46MP0009697_abnormal_copulation1.71388002
47MP0005584_abnormal_enzyme/coenzyme_acti1.71334242
48MP0008004_abnormal_stomach_pH1.66677442
49MP0002909_abnormal_adrenal_gland1.66632100
50MP0002118_abnormal_lipid_homeostasis1.65132169
51MP0001501_abnormal_sleep_pattern1.64046824
52MP0009643_abnormal_urine_homeostasis1.60327010
53MP0002736_abnormal_nociception_after1.52881044
54MP0002557_abnormal_social/conspecific_i1.52457278
55MP0004215_abnormal_myocardial_fiber1.48922552
56MP0000569_abnormal_digit_pigmentation1.48097887
57MP0004885_abnormal_endolymph1.47380140
58MP0002067_abnormal_sensory_capabilities1.45646437
59MP0001835_abnormal_antigen_presentation1.43393791
60MP0001177_atelectasis1.43127288
61MP0000955_abnormal_spinal_cord1.41016452
62MP0001970_abnormal_pain_threshold1.40211902
63MP0004811_abnormal_neuron_physiology1.39036151
64MP0003879_abnormal_hair_cell1.38763573
65MP0003724_increased_susceptibility_to1.34454277
66MP0009764_decreased_sensitivity_to1.34411507
67MP0002733_abnormal_thermal_nociception1.34217333
68MP0003633_abnormal_nervous_system1.33910195
69MP0005386_behavior/neurological_phenoty1.33796250
70MP0004924_abnormal_behavior1.33796250
71MP0001502_abnormal_circadian_rhythm1.32453764
72MP0008469_abnormal_protein_level1.29807197
73MP0002837_dystrophic_cardiac_calcinosis1.29458405
74MP0002882_abnormal_neuron_morphology1.29305493
75MP0003690_abnormal_glial_cell1.28525017
76MP0002090_abnormal_vision1.27475521
77MP0008569_lethality_at_weaning1.27126346
78MP0005646_abnormal_pituitary_gland1.24180944
79MP0005636_abnormal_mineral_homeostasis1.23551743
80MP0001299_abnormal_eye_distance/1.23404004
81MP0006036_abnormal_mitochondrial_physio1.22566826
82MP0003122_maternal_imprinting1.21715598
83MP0009785_altered_susceptibility_to1.21390149
84MP0000598_abnormal_liver_morphology1.20938237
85MP0005248_abnormal_Harderian_gland1.20666770
86MP0006276_abnormal_autonomic_nervous1.18729225
87MP0005464_abnormal_platelet_physiology1.16815969
88MP0003436_decreased_susceptibility_to1.14976064
89MP0002066_abnormal_motor_capabilities/c1.14252923
90MP0005551_abnormal_eye_electrophysiolog1.13479891
91MP0003787_abnormal_imprinting1.12701994
92MP0001440_abnormal_grooming_behavior1.12124519
93MP0002184_abnormal_innervation1.11327908
94MP0000013_abnormal_adipose_tissue1.09834538
95MP0004742_abnormal_vestibular_system1.09516854
96MP0009763_increased_sensitivity_to1.08757670
97MP0001756_abnormal_urination1.08516340
98MP0000920_abnormal_myelination1.06087028
99MP0003631_nervous_system_phenotype1.05627540
100MP0003137_abnormal_impulse_conducting1.05442797
101MP0005058_abnormal_lysosome_morphology1.05241472
102MP0005367_renal/urinary_system_phenotyp1.04486816
103MP0000516_abnormal_urinary_system1.04486816
104MP0005408_hypopigmentation1.04052144
105MP0003634_abnormal_glial_cell1.00337863
106MP0004085_abnormal_heartbeat1.00265862
107MP0005666_abnormal_adipose_tissue0.99333319
108MP0001905_abnormal_dopamine_level0.99307009
109MP0005670_abnormal_white_adipose0.99210669
110MP0002638_abnormal_pupillary_reflex0.97107746
111MP0000534_abnormal_ureter_morphology0.96080182
112MP0005275_abnormal_skin_tensile0.94975713
113MP0005647_abnormal_sex_gland0.94569836
114MP0002229_neurodegeneration0.94048333
115MP0002152_abnormal_brain_morphology0.92892020
116MP0001853_heart_inflammation0.92160350
117MP0002166_altered_tumor_susceptibility0.91758960
118MP0002136_abnormal_kidney_physiology0.90504115
119MP0001845_abnormal_inflammatory_respons0.90236026
120MP0005253_abnormal_eye_physiology0.90089951
121MP0005025_abnormal_response_to0.89853545
122MP0001346_abnormal_lacrimal_gland0.89357186
123MP0003385_abnormal_body_wall0.88379145
124MP0005451_abnormal_body_composition0.87760168
125MP0002876_abnormal_thyroid_physiology0.87534310
126MP0009765_abnormal_xenobiotic_induced0.87405663
127MP0004782_abnormal_surfactant_physiolog0.87376919
128MP0005376_homeostasis/metabolism_phenot0.87333004
129MP0001986_abnormal_taste_sensitivity0.87305685
130MP0009642_abnormal_blood_homeostasis0.87266413
131MP0004142_abnormal_muscle_tone0.86743677
132MP0003868_abnormal_feces_composition0.86607819
133MP0010234_abnormal_vibrissa_follicle0.86172026
134MP0005503_abnormal_tendon_morphology0.85787252
135MP0005167_abnormal_blood-brain_barrier0.85065152
136MP0003938_abnormal_ear_development0.84850949
137MP0002102_abnormal_ear_morphology0.83664623
138MP0002971_abnormal_brown_adipose0.82695929
139MP0000462_abnormal_digestive_system0.82082228
140MP0005671_abnormal_response_to0.81823835
141MP0000604_amyloidosis0.81670243
142MP0002234_abnormal_pharynx_morphology0.81279625
143MP0001963_abnormal_hearing_physiology0.80914926
144MP0000566_synostosis0.80847440
145MP0005645_abnormal_hypothalamus_physiol0.80785007
146MP0006082_CNS_inflammation0.79939154
147MP0000026_abnormal_inner_ear0.78823640
148MP0002419_abnormal_innate_immunity0.76229114
149MP0000685_abnormal_immune_system0.75075982
150MP0002132_abnormal_respiratory_system0.74532058
151MP0001485_abnormal_pinna_reflex0.74425633
152MP0005187_abnormal_penis_morphology0.74175424
153MP0003632_abnormal_nervous_system0.72194851
154MP0005535_abnormal_body_temperature0.71575353
155MP0002295_abnormal_pulmonary_circulatio0.70415866
156MP0002752_abnormal_somatic_nervous0.70106731
157MP0001188_hyperpigmentation0.69707233
158MP0005397_hematopoietic_system_phenotyp0.69387335
159MP0001545_abnormal_hematopoietic_system0.69387335
160MP0005623_abnormal_meninges_morphology0.69352869
161MP0010155_abnormal_intestine_physiology0.69009986
162MP0002069_abnormal_eating/drinking_beha0.68407393
163MP0001800_abnormal_humoral_immune0.67883961
164MP0001873_stomach_inflammation0.67654599
165MP0002078_abnormal_glucose_homeostasis0.67114292
166MP0004947_skin_inflammation0.66386695
167MP0005620_abnormal_muscle_contractility0.66278278
168MP0001790_abnormal_immune_system0.66196202
169MP0005387_immune_system_phenotype0.66196202
170MP0004084_abnormal_cardiac_muscle0.65924289
171MP0004043_abnormal_pH_regulation0.65718580
172MP0003300_gastrointestinal_ulcer0.65392772
173MP0001958_emphysema0.65150689
174MP0002148_abnormal_hypersensitivity_rea0.64986405
175MP0003705_abnormal_hypodermis_morpholog0.64490415
176MP0005395_other_phenotype0.64418226
177MP0005266_abnormal_metabolism0.64401748
178MP0005220_abnormal_exocrine_pancreas0.63246830
179MP0008873_increased_physiological_sensi0.63237465
180MP0001542_abnormal_bone_strength0.62887552
181MP0001661_extended_life_span0.62247702
182MP0004130_abnormal_muscle_cell0.61787745
183MP0005334_abnormal_fat_pad0.61692872
184MP0001533_abnormal_skeleton_physiology0.61233906
185MP0001765_abnormal_ion_homeostasis0.60807048
186MP0005000_abnormal_immune_tolerance0.60724809
187MP0003718_maternal_effect0.59759223
188MP0001881_abnormal_mammary_gland0.59237137
189MP0000249_abnormal_blood_vessel0.57844377
190MP0005075_abnormal_melanosome_morpholog0.57107739
191MP0002723_abnormal_immune_serum0.57102003
192MP0002254_reproductive_system_inflammat0.55012606
193MP0002928_abnormal_bile_duct0.54179368
194MP0002006_tumorigenesis0.53730365
195MP0002168_other_aberrant_phenotype0.53450807
196MP0002970_abnormal_white_adipose0.53450316
197MP0005166_decreased_susceptibility_to0.52201918
198MP0009115_abnormal_fat_cell0.52176478

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.66675061
2Abnormality of monocarboxylic acid metabolism (HP:0010996)5.37434397
3Deep venous thrombosis (HP:0002625)5.37293070
4Hypobetalipoproteinemia (HP:0003563)5.15277179
5Intrahepatic cholestasis (HP:0001406)5.11196834
6Myokymia (HP:0002411)4.80211263
7Xanthomatosis (HP:0000991)4.70005637
8Prolonged partial thromboplastin time (HP:0003645)4.68694363
9Focal motor seizures (HP:0011153)4.58185494
10Action tremor (HP:0002345)4.27833703
11Hypolipoproteinemia (HP:0010981)4.23249555
12Complement deficiency (HP:0004431)4.16992612
13Hyperammonemia (HP:0001987)3.93425928
14Abnormality of fatty-acid metabolism (HP:0004359)3.93051616
15Hyperglycinuria (HP:0003108)3.92095062
16Hyperlipoproteinemia (HP:0010980)3.90663623
17Hypoalphalipoproteinemia (HP:0003233)3.87933437
18Hyperglycinemia (HP:0002154)3.84040609
19Vascular calcification (HP:0004934)3.83133335
20Focal seizures (HP:0007359)3.77821287
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.77493865
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.77306641
23Abnormality of methionine metabolism (HP:0010901)3.74359248
24Abnormality of the common coagulation pathway (HP:0010990)3.65762901
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.60560961
26Abnormality of serine family amino acid metabolism (HP:0010894)3.57487871
27Abnormality of glycine metabolism (HP:0010895)3.57487871
28Ketosis (HP:0001946)3.49534358
29Hypoglycemic coma (HP:0001325)3.49077571
30Joint hemorrhage (HP:0005261)3.44285442
31Generalized aminoaciduria (HP:0002909)3.44252217
32Cardiovascular calcification (HP:0011915)3.39520257
33Fat malabsorption (HP:0002630)3.34393316
34Abnormality of glutamine family amino acid metabolism (HP:0010902)3.34057610
35Neurofibrillary tangles (HP:0002185)3.30651316
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.27860294
37Epidermoid cyst (HP:0200040)3.24541624
38Abnormality of pyrimidine metabolism (HP:0004353)3.24017362
39Febrile seizures (HP:0002373)3.18851468
40Abnormality of complement system (HP:0005339)3.13567932
41Abnormality of the intrinsic pathway (HP:0010989)3.13551588
42Polyphagia (HP:0002591)3.11124385
43Abnormal eating behavior (HP:0100738)3.09239113
44Abnormality of nucleobase metabolism (HP:0010932)3.07592543
45Gait imbalance (HP:0002141)3.06712069
46Urinary urgency (HP:0000012)3.00505703
47Abnormality of purine metabolism (HP:0004352)2.99380133
48Epileptic encephalopathy (HP:0200134)2.99218184
49Hyperbilirubinemia (HP:0002904)2.97497033
50Spastic gait (HP:0002064)2.89367027
51Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.87272318
52Degeneration of the lateral corticospinal tracts (HP:0002314)2.87272318
53Ankle clonus (HP:0011448)2.81866725
54Steatorrhea (HP:0002570)2.76515052
55Systemic lupus erythematosus (HP:0002725)2.76161803
56Absent speech (HP:0001344)2.74954051
57Abnormality of the corticospinal tract (HP:0002492)2.73265726
58Abnormality of serum amino acid levels (HP:0003112)2.73135653
59Impaired vibration sensation in the lower limbs (HP:0002166)2.72900937
60Intention tremor (HP:0002080)2.71229952
61Lethargy (HP:0001254)2.69118570
62Ketoacidosis (HP:0001993)2.67945952
63Acanthocytosis (HP:0001927)2.67210112
64Lower limb muscle weakness (HP:0007340)2.67158139
65Gout (HP:0001997)2.65426883
66Congenital primary aphakia (HP:0007707)2.63050793
67Hyperventilation (HP:0002883)2.63001625
68Supranuclear gaze palsy (HP:0000605)2.62556414
69Dicarboxylic aciduria (HP:0003215)2.59144312
70Abnormality of dicarboxylic acid metabolism (HP:0010995)2.59144312
71Hypercholesterolemia (HP:0003124)2.58510053
72Nephrogenic diabetes insipidus (HP:0009806)2.58372033
73Myocardial infarction (HP:0001658)2.57817892
74Drooling (HP:0002307)2.50903883
75Bundle branch block (HP:0011710)2.49748253
76Conjugated hyperbilirubinemia (HP:0002908)2.48955309
77Generalized tonic-clonic seizures (HP:0002069)2.48002750
78Epileptiform EEG discharges (HP:0011182)2.47959521
79Increased circulating renin level (HP:0000848)2.47763760
80Atonic seizures (HP:0010819)2.47127623
81Limb dystonia (HP:0002451)2.44504541
82Cerebral inclusion bodies (HP:0100314)2.42070783
83Renal cortical cysts (HP:0000803)2.40560172
84Recurrent gram-negative bacterial infections (HP:0005420)2.39302573
85Metabolic acidosis (HP:0001942)2.38939244
86Delayed CNS myelination (HP:0002188)2.38427503
87Urinary bladder sphincter dysfunction (HP:0002839)2.37758666
88EEG with generalized epileptiform discharges (HP:0011198)2.37469174
89Nausea (HP:0002018)2.36058299
90Hepatocellular carcinoma (HP:0001402)2.34124954
91Pancreatitis (HP:0001733)2.33691876
92Insidious onset (HP:0003587)2.33455998
93Termporal pattern (HP:0011008)2.33455998
94Spontaneous abortion (HP:0005268)2.29623726
95Glomerulonephritis (HP:0000099)2.28819312
96Hemiparesis (HP:0001269)2.27072386
97Proximal tubulopathy (HP:0000114)2.26225906
98Increased purine levels (HP:0004368)2.25385339
99Hyperuricemia (HP:0002149)2.25385339
100Amblyopia (HP:0000646)2.24860672
101Medial flaring of the eyebrow (HP:0010747)2.24723598
102Cerebral edema (HP:0002181)2.23346611
103Hypertriglyceridemia (HP:0002155)2.22738774
104Menorrhagia (HP:0000132)2.22120126
105Excessive salivation (HP:0003781)2.21348517
106Dialeptic seizures (HP:0011146)2.20343868
107Hypsarrhythmia (HP:0002521)2.20329289
108Cholelithiasis (HP:0001081)2.19963926
109Neoplasm of the heart (HP:0100544)2.19939981
110Progressive cerebellar ataxia (HP:0002073)2.18494446
111Abnormal gallbladder morphology (HP:0012437)2.17139865
112Broad-based gait (HP:0002136)2.14854854
113Truncal ataxia (HP:0002078)2.13802434
114Nephritis (HP:0000123)2.08521454
115Genital tract atresia (HP:0001827)2.08506331
116Absence seizures (HP:0002121)2.08116958
117Vaginal atresia (HP:0000148)2.07204378
118Abnormality of urine glucose concentration (HP:0011016)2.06878787
119Glycosuria (HP:0003076)2.06878787
120Malnutrition (HP:0004395)2.05239678
121Syncope (HP:0001279)2.05238686
122Irritability (HP:0000737)2.05123931
123Mutism (HP:0002300)2.05062381
124Gingival bleeding (HP:0000225)2.04401983
125Ulnar claw (HP:0001178)2.03589417
126Dysdiadochokinesis (HP:0002075)2.03182161
127Abnormality of vitamin metabolism (HP:0100508)2.00739931
128Esophageal varix (HP:0002040)1.98570405
129Abnormality of renal resorption (HP:0011038)1.97390901
130Dysmetria (HP:0001310)1.96609428
131Vomiting (HP:0002013)1.95997914
132Paraplegia (HP:0010550)1.94578956
133Peripheral hypomyelination (HP:0007182)1.93496277
134Elevated hepatic transaminases (HP:0002910)1.93299340
135Cholecystitis (HP:0001082)1.92478943
136Abnormal gallbladder physiology (HP:0012438)1.92478943
137Sleep apnea (HP:0010535)1.92271539
138Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.91955962
139Morphological abnormality of the pyramidal tract (HP:0002062)1.91644531
140Mitral stenosis (HP:0001718)1.89908446
141Specific learning disability (HP:0001328)1.87639248
142Increased CSF protein (HP:0002922)1.87290465
143Thrombophlebitis (HP:0004418)1.86930160
144Papillary thyroid carcinoma (HP:0002895)1.86884707
145Torticollis (HP:0000473)1.86394234
146Brushfield spots (HP:0001088)1.83432895
147Spastic paraplegia (HP:0001258)1.82548860
148Poikilocytosis (HP:0004447)1.81800750
149Megalencephaly (HP:0001355)1.79694160
150Sensorimotor neuropathy (HP:0007141)1.79581826
151Abnormality of transition element cation homeostasis (HP:0011030)1.79434588
152Neonatal onset (HP:0003623)1.78617926
153Spastic diplegia (HP:0001264)1.78491067
154Abnormality of iron homeostasis (HP:0011031)1.78384445
155Hypoplasia of the corpus callosum (HP:0002079)1.78383736
156Vacuolated lymphocytes (HP:0001922)1.78196569
157Hemorrhage of the eye (HP:0011885)1.76823217
158Hammertoe (HP:0001765)1.76715749
159Amyloidosis (HP:0011034)1.75084461
160Gait ataxia (HP:0002066)1.74926397
161Spastic tetraparesis (HP:0001285)1.73821054
162Impaired vibratory sensation (HP:0002495)1.71953045
163Late onset (HP:0003584)1.71438545
164Alacrima (HP:0000522)1.70380450
165Abnormal enzyme/coenzyme activity (HP:0012379)1.70219112
166Poor coordination (HP:0002370)1.70187982
167Anxiety (HP:0000739)1.69325210
168Acute hepatic failure (HP:0006554)1.69046815
169Methylmalonic aciduria (HP:0012120)1.67702666
170Abnormality of the calf musculature (HP:0001430)1.67659890
171Hepatic necrosis (HP:0002605)1.67563497
172Upper motor neuron abnormality (HP:0002127)1.67001951
173Spastic tetraplegia (HP:0002510)1.66975959
174Hydroxyprolinuria (HP:0003080)1.66758311
175Split foot (HP:0001839)1.65101384
176Hyperaldosteronism (HP:0000859)1.64992636
177Frequent falls (HP:0002359)1.64665001
178Heterochromia iridis (HP:0001100)1.64615123
179Depression (HP:0000716)1.63556813
180Apathy (HP:0000741)1.63205782
181Shoulder girdle muscle weakness (HP:0003547)1.62354418
182Exotropia (HP:0000577)1.61054296
183Rapidly progressive (HP:0003678)1.58841035
184Aplasia/Hypoplasia of the lens (HP:0008063)1.58269148
185Amyotrophic lateral sclerosis (HP:0007354)1.58046633
186Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.56936476
187Poor eye contact (HP:0000817)1.56533742
188Prolonged QT interval (HP:0001657)1.55844679
189Pheochromocytoma (HP:0002666)1.55321321
190True hermaphroditism (HP:0010459)1.54541726
191Sudden death (HP:0001699)1.52642272
192Left ventricular hypertrophy (HP:0001712)1.52195883
193Hyporeflexia of lower limbs (HP:0002600)1.51984704
194Decreased lacrimation (HP:0000633)1.51612537
195Scanning speech (HP:0002168)1.49663217
196Neuronal loss in central nervous system (HP:0002529)1.49636166
197Esotropia (HP:0000565)1.49104598
198Hypokalemic alkalosis (HP:0001949)1.49088703
199Intellectual disability, moderate (HP:0002342)1.48511847
200Thickened helices (HP:0000391)1.48058837

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.42373474
2MARK13.97338050
3EPHA43.51671471
4CASK3.04812084
5NEK93.03017967
6ERN12.90919456
7FRK2.89176241
8PRKD32.82218670
9BCR2.36337623
10TYK22.34780187
11NTRK32.32014055
12ACVR1B2.28829922
13FGFR42.26544559
14UHMK12.18973500
15FLT32.11414434
16MST42.04919209
17MAPK131.98540141
18MAP3K141.97176426
19LATS21.96334289
20DAPK21.94516443
21PAK61.93707670
22NTRK21.91460184
23MAP3K41.86000841
24SIK11.82786515
25MAP2K71.81577954
26MINK11.81561848
27LIMK11.79370988
28EIF2AK11.77759018
29PAK31.69015059
30TESK11.68367776
31PLK21.65936050
32TBK11.65595814
33PTK61.63363903
34PIK3CG1.58763415
35CAMKK21.50066561
36TAOK31.49625213
37DDR21.48906428
38JAK31.42337292
39PINK11.42250444
40NTRK11.42187203
41LRRK21.38818467
42PKN21.38685981
43PDK41.35308594
44PDK31.35308594
45JAK11.31328809
46MAP2K31.30642973
47CDK51.30410026
48CAMKK11.27500081
49SGK4941.27329319
50SGK2231.27329319
51MAP4K21.27071330
52MAP3K111.26132510
53MAP4K11.25344833
54PDK21.24827424
55IRAK31.24441387
56BRSK21.23334200
57JAK21.22438752
58CAMK1G1.21594673
59WNK41.21547007
60ZAP701.20838071
61STK101.18975277
62WNK31.18617639
63ARAF1.17405092
64MST1R1.16640372
65AKT31.16632004
66TRIB31.16014699
67IKBKE1.15150471
68FER1.15114548
69NEK11.14509923
70CAMK2B1.14433659
71FGFR31.12374330
72CAMK1D1.11142476
73CSF1R1.08076451
74PIM21.07519567
75GRK51.07063494
76MAP3K51.06959284
77ABL21.06132139
78CSNK1G21.04973884
79CAMK11.03913740
80MAP3K31.00718973
81MAPKAPK30.99291692
82MAP2K40.98605906
83PBK0.98010624
84TESK20.97817340
85TRIM280.96777377
86BTK0.96381153
87ERBB30.95965557
88PRKCG0.94431526
89DMPK0.94130250
90NME20.93776567
91STK160.92412307
92PHKG10.89593768
93PHKG20.89593768
94CAMK2A0.88790481
95CDK60.88609145
96MAPK110.87687041
97CAMK2G0.86978199
98MAP3K90.86126970
99STK390.86096297
100KDR0.85547128
101TEC0.85361443
102STK380.85149355
103MAP3K120.84154868
104EIF2AK30.82944760
105PRKCE0.82310381
106PNCK0.82205257
107KIT0.81271108
108BUB10.80535866
109TGFBR10.78298806
110IKBKB0.76385433
111RPS6KA40.74368995
112MYLK0.73845728
113GRK10.72992471
114NEK60.72340448
115TXK0.72228913
116STK38L0.70332746
117DYRK1A0.68633734
118STK30.67384775
119ROCK20.67188896
120MAPKAPK50.66723392
121PRKCH0.66208343
122CAMK40.66105382
123CDK140.66040792
124SIK30.65783382
125SCYL20.65720696
126PRKCZ0.64583944
127CSNK1G30.64216777
128CDK180.64027486
129CSNK1A1L0.63230084
130MAP2K60.62644850
131PDGFRA0.61892954
132TYRO30.61600991
133SIK20.60741750
134ROCK10.60704498
135PKN10.60574035
136DYRK20.60399070
137CDK150.59563545
138MATK0.59256913
139SGK20.58946822
140PLK40.58368711
141ERBB40.58124896
142CHUK0.57251768
143CAMK2D0.57200049
144LATS10.55427006
145CDK11A0.54217189
146KSR10.54176385
147BRSK10.53913998
148MAPK100.53676131
149CCNB10.53513053
150PIM10.53225138
151FGFR20.51743946
152RPS6KB10.50691474
153WEE10.49121871
154TSSK60.48659180
155CSNK1G10.48176771
156DAPK30.47895107
157MELK0.47728551
158SYK0.47543898
159DAPK10.47213777
160RIPK10.46920695
161MAPK40.46902242
162CDK40.46861810
163NUAK10.46442185
164TRPM70.46319677
165CSNK1A10.45757750
166BRD40.44767494
167PRKAA10.43944762
168MAP3K60.43543505
169EPHA30.43448474
170EPHA20.43352444
171SGK30.43325357
172DYRK1B0.43303063
173MAP2K10.43284276
174NEK20.42649523
175MARK20.41044220
176BMPR1B0.40688340
177TNIK0.39718034
178RPS6KA30.39489517
179ITK0.39379935
180LMTK20.38075518
181PRKCQ0.37579486
182LYN0.37178461
183PIK3CA0.36802758
184CSK0.35341566

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.65542491
2Synaptic vesicle cycle_Homo sapiens_hsa047213.25521121
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.13411375
4Nicotine addiction_Homo sapiens_hsa050333.09499096
5Pentose and glucuronate interconversions_Homo sapiens_hsa000403.01998682
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.96115820
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61989479
8GABAergic synapse_Homo sapiens_hsa047272.53037191
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.50746961
10Nitrogen metabolism_Homo sapiens_hsa009102.46713918
11Arginine biosynthesis_Homo sapiens_hsa002202.46528798
12Fatty acid degradation_Homo sapiens_hsa000712.43854445
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39016217
14Tryptophan metabolism_Homo sapiens_hsa003802.34863746
15Complement and coagulation cascades_Homo sapiens_hsa046102.33106777
16Propanoate metabolism_Homo sapiens_hsa006402.32142698
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.28858883
18Circadian entrainment_Homo sapiens_hsa047132.23624908
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.18020620
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.14042410
21Morphine addiction_Homo sapiens_hsa050322.10772858
22Peroxisome_Homo sapiens_hsa041462.09161646
23Insulin secretion_Homo sapiens_hsa049112.08172438
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.06165460
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.05588144
26Glutamatergic synapse_Homo sapiens_hsa047242.02203954
27Amphetamine addiction_Homo sapiens_hsa050312.01287246
28Collecting duct acid secretion_Homo sapiens_hsa049661.98393962
29Dopaminergic synapse_Homo sapiens_hsa047281.94329924
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.87801876
31Cocaine addiction_Homo sapiens_hsa050301.83258569
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.82286969
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.81868353
34Chemical carcinogenesis_Homo sapiens_hsa052041.81186527
35Fatty acid metabolism_Homo sapiens_hsa012121.76441831
36beta-Alanine metabolism_Homo sapiens_hsa004101.75469262
37Histidine metabolism_Homo sapiens_hsa003401.73942017
38Selenocompound metabolism_Homo sapiens_hsa004501.72003429
39Butanoate metabolism_Homo sapiens_hsa006501.71947442
40Retinol metabolism_Homo sapiens_hsa008301.71693365
41PPAR signaling pathway_Homo sapiens_hsa033201.70885245
42Caffeine metabolism_Homo sapiens_hsa002321.70685643
43Long-term potentiation_Homo sapiens_hsa047201.66721694
44Staphylococcus aureus infection_Homo sapiens_hsa051501.61488712
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61230272
46Vibrio cholerae infection_Homo sapiens_hsa051101.60922194
47Starch and sucrose metabolism_Homo sapiens_hsa005001.58221322
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.58102239
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.58058129
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55962495
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52606277
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51947777
53Gastric acid secretion_Homo sapiens_hsa049711.49439587
54Pyruvate metabolism_Homo sapiens_hsa006201.49436829
55Steroid hormone biosynthesis_Homo sapiens_hsa001401.48993484
56Phenylalanine metabolism_Homo sapiens_hsa003601.44179067
57Salivary secretion_Homo sapiens_hsa049701.43398625
58Folate biosynthesis_Homo sapiens_hsa007901.42824136
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40210294
60Carbon metabolism_Homo sapiens_hsa012001.39101910
61Sulfur metabolism_Homo sapiens_hsa009201.38485943
62Cholinergic synapse_Homo sapiens_hsa047251.34819016
63Fatty acid elongation_Homo sapiens_hsa000621.31567555
64Renin secretion_Homo sapiens_hsa049241.30301655
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30110337
66cAMP signaling pathway_Homo sapiens_hsa040241.26634108
67Tyrosine metabolism_Homo sapiens_hsa003501.25930308
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.23398542
69Long-term depression_Homo sapiens_hsa047301.23110062
70Biosynthesis of amino acids_Homo sapiens_hsa012301.22437193
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21413997
72Oxytocin signaling pathway_Homo sapiens_hsa049211.20970787
73Taste transduction_Homo sapiens_hsa047421.18465688
74Vitamin B6 metabolism_Homo sapiens_hsa007501.17592214
75Circadian rhythm_Homo sapiens_hsa047101.12541825
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.11564967
77Bile secretion_Homo sapiens_hsa049761.11440042
78Pentose phosphate pathway_Homo sapiens_hsa000301.08503483
79Gap junction_Homo sapiens_hsa045401.06005131
80ABC transporters_Homo sapiens_hsa020101.04871503
81Vitamin digestion and absorption_Homo sapiens_hsa049771.04452048
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04032832
83Dilated cardiomyopathy_Homo sapiens_hsa054141.00738318
84Glutathione metabolism_Homo sapiens_hsa004800.98200465
85Calcium signaling pathway_Homo sapiens_hsa040200.98039397
86Estrogen signaling pathway_Homo sapiens_hsa049150.97471131
87Serotonergic synapse_Homo sapiens_hsa047260.97165973
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95909845
89Axon guidance_Homo sapiens_hsa043600.94935146
90One carbon pool by folate_Homo sapiens_hsa006700.94489242
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93787725
92Fat digestion and absorption_Homo sapiens_hsa049750.92707774
93Cardiac muscle contraction_Homo sapiens_hsa042600.91249443
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90100632
95Melanogenesis_Homo sapiens_hsa049160.89033474
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88315630
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.88067967
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87092557
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.85750761
100Pancreatic secretion_Homo sapiens_hsa049720.84509215
101Sulfur relay system_Homo sapiens_hsa041220.84422291
102GnRH signaling pathway_Homo sapiens_hsa049120.81825069
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81314175
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78746892
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77918251
106Proteasome_Homo sapiens_hsa030500.77766893
107Oocyte meiosis_Homo sapiens_hsa041140.76266407
108Tight junction_Homo sapiens_hsa045300.73058474
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72998696
110Arginine and proline metabolism_Homo sapiens_hsa003300.72588955
111Type II diabetes mellitus_Homo sapiens_hsa049300.72084051
112* AMPK signaling pathway_Homo sapiens_hsa041520.71910925
113Glioma_Homo sapiens_hsa052140.71081348
114Glycerolipid metabolism_Homo sapiens_hsa005610.70581212
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.70086386
116Steroid biosynthesis_Homo sapiens_hsa001000.68288728
117Phototransduction_Homo sapiens_hsa047440.67753702
118Olfactory transduction_Homo sapiens_hsa047400.67628658
119Dorso-ventral axis formation_Homo sapiens_hsa043200.66125600
120Ras signaling pathway_Homo sapiens_hsa040140.65499640
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64649496
122Inositol phosphate metabolism_Homo sapiens_hsa005620.64552205
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64241767
124Endocytosis_Homo sapiens_hsa041440.63486719
125ErbB signaling pathway_Homo sapiens_hsa040120.63274727
126Rap1 signaling pathway_Homo sapiens_hsa040150.61243655
127Hippo signaling pathway_Homo sapiens_hsa043900.59427057
128Thyroid hormone synthesis_Homo sapiens_hsa049180.57133119
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55769049
130Metabolic pathways_Homo sapiens_hsa011000.55233409
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54419612
132Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54337854
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.54198266
134Ovarian steroidogenesis_Homo sapiens_hsa049130.54078632
135Fructose and mannose metabolism_Homo sapiens_hsa000510.53621783
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52001748
137Endometrial cancer_Homo sapiens_hsa052130.49285817
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49133195
139Adherens junction_Homo sapiens_hsa045200.48460803
140Maturity onset diabetes of the young_Homo sapiens_hsa049500.48286995
141Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47496738
142Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46426473
143Glucagon signaling pathway_Homo sapiens_hsa049220.45679430
144Hedgehog signaling pathway_Homo sapiens_hsa043400.44278747
145Galactose metabolism_Homo sapiens_hsa000520.43822712
146Choline metabolism in cancer_Homo sapiens_hsa052310.42813376
147Insulin signaling pathway_Homo sapiens_hsa049100.42757245
148Neurotrophin signaling pathway_Homo sapiens_hsa047220.41020619
149Fatty acid biosynthesis_Homo sapiens_hsa000610.39455434
150Focal adhesion_Homo sapiens_hsa045100.39100111
151Legionellosis_Homo sapiens_hsa051340.38206020
152Regulation of autophagy_Homo sapiens_hsa041400.37866923
153Renin-angiotensin system_Homo sapiens_hsa046140.36143190
154Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33202087
155Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33057458
156Adipocytokine signaling pathway_Homo sapiens_hsa049200.32450893
157Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31171276
158Lysine degradation_Homo sapiens_hsa003100.29137414
159Insulin resistance_Homo sapiens_hsa049310.28264401
160RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28134254
161Pyrimidine metabolism_Homo sapiens_hsa002400.26970529
162Protein export_Homo sapiens_hsa030600.22302390
163Lysosome_Homo sapiens_hsa041420.21318865
164Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18750473
165Antigen processing and presentation_Homo sapiens_hsa046120.18401422
166Hepatitis C_Homo sapiens_hsa051600.18139965
167Intestinal immune network for IgA production_Homo sapiens_hsa046720.17076438
168Glycosaminoglycan degradation_Homo sapiens_hsa005310.16548435
169Glycerophospholipid metabolism_Homo sapiens_hsa005640.09508461
170Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.08161183
171Influenza A_Homo sapiens_hsa051640.07697800
172Other glycan degradation_Homo sapiens_hsa005110.07635287
173Arachidonic acid metabolism_Homo sapiens_hsa005900.06670805
174Measles_Homo sapiens_hsa051620.05241886
175Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.05014069
176Prion diseases_Homo sapiens_hsa050200.05002866
177Allograft rejection_Homo sapiens_hsa053300.04793204
178Toll-like receptor signaling pathway_Homo sapiens_hsa046200.03503286
179Mineral absorption_Homo sapiens_hsa049780.02462293
180Pertussis_Homo sapiens_hsa051330.02331137
181alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.01655675

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