CABIN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)4.59982747
2positive regulation of gamma-delta T cell activation (GO:0046645)4.28068512
3mannose metabolic process (GO:0006013)4.01374761
4negative regulation of histone methylation (GO:0031061)3.87702478
5regulation of gamma-delta T cell differentiation (GO:0045586)3.80053210
6negative regulation of cell killing (GO:0031342)3.65837340
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.65837340
8positive regulation of histone deacetylation (GO:0031065)3.63680632
9regulation of histone H3-K27 methylation (GO:0061085)3.58010156
10positive thymic T cell selection (GO:0045059)3.57908266
11regulation of gamma-delta T cell activation (GO:0046643)3.45156152
12negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.38196076
13dosage compensation (GO:0007549)3.33802160
14positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.32312710
15glucocorticoid receptor signaling pathway (GO:0042921)3.31974448
16peptidyl-lysine dimethylation (GO:0018027)3.30897150
17positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.22847871
18response to muramyl dipeptide (GO:0032495)3.20208036
19positive regulation of gene expression, epigenetic (GO:0045815)3.19565822
20nuclear pore complex assembly (GO:0051292)3.16064465
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.13901206
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.13901206
23adherens junction assembly (GO:0034333)3.11024651
24mitotic sister chromatid cohesion (GO:0007064)3.08207404
25negative regulation of myotube differentiation (GO:0010832)3.07904231
26intracellular estrogen receptor signaling pathway (GO:0030520)3.06394064
27histone lysine demethylation (GO:0070076)3.06130524
28thymic T cell selection (GO:0045061)3.04470578
29focal adhesion assembly (GO:0048041)3.04089311
30cell-substrate adherens junction assembly (GO:0007045)3.04089311
31antigen processing and presentation via MHC class Ib (GO:0002475)3.03202595
32apoptotic process involved in morphogenesis (GO:0060561)3.02530451
33regulation of translational fidelity (GO:0006450)3.01255093
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.00689324
35negative thymic T cell selection (GO:0045060)2.99746901
36histone H2A monoubiquitination (GO:0035518)2.99230429
37regulation of NFAT protein import into nucleus (GO:0051532)2.98752902
383-UTR-mediated mRNA stabilization (GO:0070935)2.97976074
39embryonic process involved in female pregnancy (GO:0060136)2.97891638
40negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.97767200
41cellular response to epidermal growth factor stimulus (GO:0071364)2.97485020
42regulation of extracellular matrix disassembly (GO:0010715)2.95674683
43response to laminar fluid shear stress (GO:0034616)2.94635297
44histone H3-K4 methylation (GO:0051568)2.93050026
45negative T cell selection (GO:0043383)2.92970111
46DNA unwinding involved in DNA replication (GO:0006268)2.92830186
47heterochromatin organization (GO:0070828)2.89844085
48histone demethylation (GO:0016577)2.88430567
49corticosteroid receptor signaling pathway (GO:0031958)2.88350403
50positive T cell selection (GO:0043368)2.87435170
51mitotic chromosome condensation (GO:0007076)2.87381621
52positive regulation by symbiont of host defense response (GO:0052509)2.86912453
53modulation by symbiont of host defense response (GO:0052031)2.86912453
54modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.86912453
55modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.86912453
56positive regulation by organism of defense response of other organism involved in symbiotic interact2.86912453
57modulation by symbiont of host immune response (GO:0052553)2.86912453
58nuclear pore organization (GO:0006999)2.86541573
59regulation of histone H3-K9 methylation (GO:0051570)2.86422111
60protein localization to kinetochore (GO:0034501)2.86052487
61positive regulation of RNA splicing (GO:0033120)2.85412246
62positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.84248570
63histone H3-K36 demethylation (GO:0070544)2.83168052
64nucleosome disassembly (GO:0006337)2.80027404
65protein-DNA complex disassembly (GO:0032986)2.80027404
66activation of Rac GTPase activity (GO:0032863)2.77192903
67negative regulation of histone modification (GO:0031057)2.76554908
68negative regulation of erythrocyte differentiation (GO:0045647)2.76532571
69cytoplasmic mRNA processing body assembly (GO:0033962)2.76007637
70response to epidermal growth factor (GO:0070849)2.74945802
71antigen processing and presentation of endogenous antigen (GO:0019883)2.74687131
72response to interleukin-15 (GO:0070672)2.74022728
73modulation by virus of host process (GO:0019054)2.73782634
74histone H4 deacetylation (GO:0070933)2.72400898
75positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.70788946
76RNA stabilization (GO:0043489)2.70164519
77mRNA stabilization (GO:0048255)2.70164519
78NLS-bearing protein import into nucleus (GO:0006607)2.67757388
79leukocyte aggregation (GO:0070486)2.67647744
80positive regulation of protein deacetylation (GO:0090312)2.66828353
81mitotic nuclear envelope disassembly (GO:0007077)2.65309019
82T cell selection (GO:0045058)2.65151661
83histone lysine methylation (GO:0034968)2.65008086
84detection of bacterium (GO:0016045)2.63746852
85gene silencing (GO:0016458)2.63446113
86negative regulation of RNA splicing (GO:0033119)2.62674168
87regulation of interleukin-12 biosynthetic process (GO:0045075)2.61870927
88membrane disassembly (GO:0030397)2.60720598
89nuclear envelope disassembly (GO:0051081)2.60720598
90semaphorin-plexin signaling pathway (GO:0071526)2.60267507
91regulation of nucleobase-containing compound transport (GO:0032239)2.58356904
92epithelial cell differentiation involved in prostate gland development (GO:0060742)2.58303612
93negative regulation of gene expression, epigenetic (GO:0045814)2.58299665
94DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.58026648
95DNA duplex unwinding (GO:0032508)2.56590618
96modulation by symbiont of host cellular process (GO:0044068)2.55854373
97chromatin assembly (GO:0031497)2.55463727
98detection of other organism (GO:0098543)2.55378712
99negative regulation of phagocytosis (GO:0050765)2.55351898
100positive regulation of Cdc42 GTPase activity (GO:0043089)2.55232845
101positive regulation of Rap GTPase activity (GO:0032854)2.55138210
102DNA geometric change (GO:0032392)2.54850239
103regulation of mitotic spindle organization (GO:0060236)2.54567354
104Peyers patch development (GO:0048541)2.54140594
105mucosal-associated lymphoid tissue development (GO:0048537)2.54140594
106chromatin silencing (GO:0006342)2.53952910
107protein localization to chromosome, centromeric region (GO:0071459)2.52960803
108translesion synthesis (GO:0019985)2.52602517
109negative regulation of chromatin modification (GO:1903309)2.51986529
110spliceosomal tri-snRNP complex assembly (GO:0000244)2.51931510
111COPI coating of Golgi vesicle (GO:0048205)2.51616787
112Golgi transport vesicle coating (GO:0048200)2.51616787
113regulation of mammary gland epithelial cell proliferation (GO:0033599)2.51154310
114regulation of erythrocyte differentiation (GO:0045646)2.50879021
115signal complex assembly (GO:0007172)2.50752104
116retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.50439639
117negative regulation of histone acetylation (GO:0035067)2.50006610
118protein dealkylation (GO:0008214)2.49933872
119protein demethylation (GO:0006482)2.49933872
120cytoskeletal anchoring at plasma membrane (GO:0007016)2.49272990
121natural killer cell differentiation (GO:0001779)2.49095142
122histone H3-K4 trimethylation (GO:0080182)2.48956677
123histone H4-K16 acetylation (GO:0043984)2.48735016
124insulin-like growth factor receptor signaling pathway (GO:0048009)2.48372636
125gene silencing by RNA (GO:0031047)2.47925735
126histone H3-K9 demethylation (GO:0033169)2.47814890
127germinal center formation (GO:0002467)2.47603040
128maternal placenta development (GO:0001893)2.47062684
129positive regulation of protein dephosphorylation (GO:0035307)2.46470759
130regulation of leukocyte degranulation (GO:0043300)2.44915572
131cellular extravasation (GO:0045123)2.42841625
132negative regulation of cell size (GO:0045792)2.42658539
133poly(A)+ mRNA export from nucleus (GO:0016973)2.42152339
134regulation of spindle organization (GO:0090224)2.42048306
135activation of JUN kinase activity (GO:0007257)2.41223086
136pore complex assembly (GO:0046931)2.40513545
137B cell receptor signaling pathway (GO:0050853)2.40266806
138regulation of myeloid leukocyte mediated immunity (GO:0002886)2.38861872
139histone H4 acetylation (GO:0043967)2.38844588
140sister chromatid segregation (GO:0000819)2.38553470
141histone methylation (GO:0016571)2.38162714
142alternative mRNA splicing, via spliceosome (GO:0000380)2.36896109
143cell-cell junction maintenance (GO:0045217)2.36487288
144positive regulation of blood vessel endothelial cell migration (GO:0043536)2.36282314
145megakaryocyte development (GO:0035855)2.36153988
146negative regulation of mRNA metabolic process (GO:1903312)2.35934418
147cellular response to interleukin-4 (GO:0071353)2.35616465
148protein localization to endosome (GO:0036010)2.35455099
149regulation of ARF GTPase activity (GO:0032312)2.35243359
150regulation of ARF protein signal transduction (GO:0032012)2.35024332
151negative regulation of mRNA processing (GO:0050686)2.34897266
152nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.34395986
153cell-substrate junction assembly (GO:0007044)2.33828279
154regulation of cholesterol homeostasis (GO:2000188)2.33579626
155negative regulation of leukocyte mediated immunity (GO:0002704)2.33518214
156regulation of chromatin binding (GO:0035561)2.33348204
157mitotic G1 DNA damage checkpoint (GO:0031571)2.32955924
158embryonic hemopoiesis (GO:0035162)2.32884315
159regulation of translational termination (GO:0006449)2.32710892
160regulation of histone H3-K4 methylation (GO:0051569)2.32012249
161regulation of RNA export from nucleus (GO:0046831)2.31852098
162positive regulation of granulocyte differentiation (GO:0030854)2.31014484
163DNA damage response, signal transduction resulting in transcription (GO:0042772)2.29395659
164peptidyl-lysine trimethylation (GO:0018023)2.29100900
165regulation of sister chromatid cohesion (GO:0007063)2.29009787

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.42113081
2* MYC_22102868_ChIP-Seq_BL_Human4.39334923
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.23120084
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.95926437
5* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.40362439
6* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.04957853
7VDR_21846776_ChIP-Seq_THP-1_Human3.02541662
8TCF7_22412390_ChIP-Seq_EML_Mouse2.87798127
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.79181091
10KDM2B_26808549_Chip-Seq_DND41_Human2.61805880
11KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.49048069
12KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.47554816
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.42669162
14SCL_19346495_ChIP-Seq_HPC-7_Human2.41936392
15UTX_26944678_Chip-Seq_JUKART_Human2.21854744
16MAF_26560356_Chip-Seq_TH1_Human2.16682994
17CIITA_25753668_ChIP-Seq_RAJI_Human2.12822498
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.11396444
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00827328
20E2F4_17652178_ChIP-ChIP_JURKAT_Human1.98564486
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.89016528
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.86114349
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83622008
24VDR_24763502_ChIP-Seq_THP-1_Human1.82068758
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.80219807
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.77647609
27MYB_26560356_Chip-Seq_TH2_Human1.76417496
28KDM2B_26808549_Chip-Seq_JURKAT_Human1.74980394
29TP63_17297297_ChIP-ChIP_HaCaT_Human1.74348616
30MYB_26560356_Chip-Seq_TH1_Human1.74010612
31SPI1_23127762_ChIP-Seq_K562_Human1.69813397
32TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.69183111
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69037684
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.68697138
35FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66726498
36CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.62992884
37DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.61745504
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61735526
39SMC4_20622854_ChIP-Seq_HELA_Human1.58081288
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.56386779
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.55562476
42* E2F1_21310950_ChIP-Seq_MCF-7_Human1.54697363
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.54307893
44ZFP281_27345836_Chip-Seq_ESCs_Mouse1.53523995
45GATA1_22025678_ChIP-Seq_K562_Human1.51384279
46LXR_22292898_ChIP-Seq_THP-1_Human1.47718054
47MAF_26560356_Chip-Seq_TH2_Human1.47261122
48KDM2B_26808549_Chip-Seq_K562_Human1.47060888
49SA1_27219007_Chip-Seq_ERYTHROID_Human1.44782760
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43197737
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41505830
52* GATA1_19941827_ChIP-Seq_MEL_Mouse1.40935846
53NCOR1_26117541_ChIP-Seq_K562_Human1.39173531
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39004323
55MYB_21317192_ChIP-Seq_ERMYB_Mouse1.37905972
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34876034
57DROSHA_22980978_ChIP-Seq_HELA_Human1.33868334
58GATA1_19941826_ChIP-Seq_K562_Human1.33862537
59CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.31290150
60RUNX_20019798_ChIP-Seq_JUKART_Human1.31288469
61UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31000605
62ESR2_21235772_ChIP-Seq_MCF-7_Human1.30881126
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30364639
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29738516
65* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.28279367
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27243377
67RUNX1_27514584_Chip-Seq_MCF-7_Human1.26850774
68STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26675034
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23594980
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23471929
71CLOCK_20551151_ChIP-Seq_293T_Human1.23282251
72* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21053978
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20343136
74CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20205024
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18985199
76TET1_21451524_ChIP-Seq_MESCs_Mouse1.18846427
77* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18394661
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17596216
79* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17078397
80* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16203314
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16079622
82* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14429902
83RACK7_27058665_Chip-Seq_MCF-7_Human1.14267448
84KDM5A_27292631_Chip-Seq_BREAST_Human1.14228002
85PKCTHETA_26484144_Chip-Seq_BREAST_Human1.11958854
86NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11476922
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10576473
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09466685
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08897402
90WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07616416
91* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07107753
92BCOR_27268052_Chip-Seq_Bcells_Human1.05921105
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05920437
94CREB1_26743006_Chip-Seq_LNCaP_Human1.05659116
95TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04945517
96TP63_19390658_ChIP-ChIP_HaCaT_Human1.04930063
97P68_20966046_ChIP-Seq_HELA_Human1.03490204
98SPI1_23547873_ChIP-Seq_NB4_Human1.03016784
99STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02607647
100ERG_21242973_ChIP-ChIP_JURKAT_Human1.02559613
101SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02206621
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01559540
103* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01187916
104ATF3_27146783_Chip-Seq_COLON_Human1.00543552
105* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00470898
106CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00057293
107EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99826943
108KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98757152
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98567116
110ELF1_20517297_ChIP-Seq_JURKAT_Human0.98467280
111RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98122944
112MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97585637
113CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97426517
114* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96640615
115TP53_22127205_ChIP-Seq_IMR90_Human0.96549504
116* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95987608
117* GATA3_27048872_Chip-Seq_THYMUS_Human0.95848949
118TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.95143467
119ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95101609
120* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94624071
121TP63_22573176_ChIP-Seq_HFKS_Human0.93204247
122TFEB_21752829_ChIP-Seq_HELA_Human0.92209961
123SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92004879
124* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91785648
125ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91783853
126IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.91681838
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91113185
128SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90325380
129SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89500424
130MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.89433988
131ZNF263_19887448_ChIP-Seq_K562_Human0.88035995

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.69544234
2MP0002396_abnormal_hematopoietic_system3.18136309
3MP0004808_abnormal_hematopoietic_stem2.63933179
4MP0010352_gastrointestinal_tract_polyps2.60812700
5MP0005076_abnormal_cell_differentiation2.57711776
6MP0003111_abnormal_nucleus_morphology2.54624889
7MP0005451_abnormal_body_composition2.48905129
8MP0003300_gastrointestinal_ulcer2.47827601
9MP0009278_abnormal_bone_marrow2.46904662
10MP0008260_abnormal_autophagy2.46611597
11MP0005409_darkened_coat_color2.43267089
12MP0008961_abnormal_basal_metabolism2.43160445
13MP0010307_abnormal_tumor_latency2.30384190
14MP0005058_abnormal_lysosome_morphology2.21556988
15MP0003763_abnormal_thymus_physiology2.17741332
16MP0010094_abnormal_chromosome_stability2.16165051
17MP0005397_hematopoietic_system_phenotyp2.09566529
18MP0001545_abnormal_hematopoietic_system2.09566529
19MP0004858_abnormal_nervous_system2.07589332
20MP0003705_abnormal_hypodermis_morpholog2.04719671
21MP0004510_myositis2.01517253
22MP0003077_abnormal_cell_cycle2.00881648
23MP0000685_abnormal_immune_system1.99083438
24MP0008877_abnormal_DNA_methylation1.98278382
25MP0003303_peritoneal_inflammation1.97647495
26MP0003787_abnormal_imprinting1.97164134
27MP0002398_abnormal_bone_marrow1.97149617
28MP0000703_abnormal_thymus_morphology1.94662568
29MP0002166_altered_tumor_susceptibility1.90569996
30MP0000678_abnormal_parathyroid_gland1.84732275
31MP0004381_abnormal_hair_follicle1.80818210
32MP0002249_abnormal_larynx_morphology1.67598696
33MP0001873_stomach_inflammation1.62414867
34MP0001730_embryonic_growth_arrest1.59534660
35MP0003693_abnormal_embryo_hatching1.56339616
36MP0002722_abnormal_immune_system1.56069950
37MP0010234_abnormal_vibrissa_follicle1.55276021
38MP0004264_abnormal_extraembryonic_tissu1.54984899
39MP0000350_abnormal_cell_proliferation1.54208184
40* MP0001800_abnormal_humoral_immune1.48822118
41MP0003329_amyloid_beta_deposits1.47968906
42MP0000689_abnormal_spleen_morphology1.46984736
43MP0002006_tumorigenesis1.46869112
44MP0003279_aneurysm1.45783525
45MP0002419_abnormal_innate_immunity1.44609545
46MP0001849_ear_inflammation1.43548730
47MP0008007_abnormal_cellular_replicative1.43310698
48MP0003172_abnormal_lysosome_physiology1.40783847
49MP0005025_abnormal_response_to1.40211223
50MP0001348_abnormal_lacrimal_gland1.39727843
51MP0003183_abnormal_peptide_metabolism1.39391453
52MP0000716_abnormal_immune_system1.38747026
53MP0003866_abnormal_defecation1.37757551
54MP0001958_emphysema1.33763736
55MP0004859_abnormal_synaptic_plasticity1.33630431
56MP0002653_abnormal_ependyma_morphology1.32654856
57* MP0002420_abnormal_adaptive_immunity1.32505230
58* MP0001819_abnormal_immune_cell1.29869400
59MP0000858_altered_metastatic_potential1.28980395
60MP0002429_abnormal_blood_cell1.28598179
61MP0003283_abnormal_digestive_organ1.27502695
62MP0005464_abnormal_platelet_physiology1.27003756
63MP0008438_abnormal_cutaneous_collagen1.26867960
64MP0003123_paternal_imprinting1.26579945
65MP0002089_abnormal_postnatal_growth/wei1.26316588
66MP0000490_abnormal_crypts_of1.26051543
67MP0003566_abnormal_cell_adhesion1.25474543
68MP0003191_abnormal_cellular_cholesterol1.25341698
69MP0008057_abnormal_DNA_replication1.24950492
70MP0002086_abnormal_extraembryonic_tissu1.24821008
71MP0004957_abnormal_blastocyst_morpholog1.24558491
72MP0001835_abnormal_antigen_presentation1.23715972
73MP0002132_abnormal_respiratory_system1.23710370
74MP0002084_abnormal_developmental_patter1.22169436
75* MP0002452_abnormal_antigen_presenting1.21718928
76MP0003453_abnormal_keratinocyte_physiol1.20289862
77MP0004197_abnormal_fetal_growth/weight/1.20089648
78MP0003690_abnormal_glial_cell1.16845687
79MP0003121_genomic_imprinting1.16664357
80MP0003984_embryonic_growth_retardation1.16438769
81MP0005174_abnormal_tail_pigmentation1.15704560
82MP0001851_eye_inflammation1.15541593
83MP0005666_abnormal_adipose_tissue1.15537599
84MP0002088_abnormal_embryonic_growth/wei1.15177538
85MP0005387_immune_system_phenotype1.14843714
86MP0001790_abnormal_immune_system1.14843714
87MP0004947_skin_inflammation1.14571484
88MP0001672_abnormal_embryogenesis/_devel1.14224792
89MP0005380_embryogenesis_phenotype1.14224792
90* MP0002723_abnormal_immune_serum1.14001031
91MP0003091_abnormal_cell_migration1.13893215
92MP0002405_respiratory_system_inflammati1.13619869
93* MP0002080_prenatal_lethality1.10515084
94MP0000733_abnormal_muscle_development1.09103436
95MP0005671_abnormal_response_to1.08177564
96MP0002998_abnormal_bone_remodeling1.07935665
97MP0001697_abnormal_embryo_size1.07240773
98MP0002019_abnormal_tumor_incidence1.05933350
99MP0008995_early_reproductive_senescence1.05580679
100MP0002877_abnormal_melanocyte_morpholog1.04678678
101MP0001533_abnormal_skeleton_physiology1.04017443
102MP0005310_abnormal_salivary_gland1.01687343
103MP0010155_abnormal_intestine_physiology1.01371183
104MP0002925_abnormal_cardiovascular_devel0.99941976
105MP0009672_abnormal_birth_weight0.99334124
106MP0000313_abnormal_cell_death0.98287689
107MP0005375_adipose_tissue_phenotype0.97917767
108MP0005621_abnormal_cell_physiology0.97842162
109MP0004233_abnormal_muscle_weight0.96613569
110MP0002085_abnormal_embryonic_tissue0.96302604
111MP0001915_intracranial_hemorrhage0.96021553
112MP0000465_gastrointestinal_hemorrhage0.93008166
113MP0002009_preneoplasia0.91696672
114MP0003045_fibrosis0.91573098
115MP0005000_abnormal_immune_tolerance0.91069944
116MP0008770_decreased_survivor_rate0.89369575
117MP0009333_abnormal_splenocyte_physiolog0.88602871
118MP0008058_abnormal_DNA_repair0.87511263
119MP0010630_abnormal_cardiac_muscle0.86703911
120MP0005023_abnormal_wound_healing0.85688409
121MP0003436_decreased_susceptibility_to0.85192150
122MP0000767_abnormal_smooth_muscle0.84301744
123MP0004185_abnormal_adipocyte_glucose0.83272959
124MP0000003_abnormal_adipose_tissue0.81368165
125MP0006054_spinal_hemorrhage0.80426571
126MP0000266_abnormal_heart_morphology0.80169365
127MP0002933_joint_inflammation0.80158306
128MP0000681_abnormal_thyroid_gland0.80087019
129MP0009703_decreased_birth_body0.79744728
130MP0003115_abnormal_respiratory_system0.79123843
131MP0000371_diluted_coat_color0.78104536
132MP0005384_cellular_phenotype0.74832188
133MP0002970_abnormal_white_adipose0.72316666
134MP0003724_increased_susceptibility_to0.71533464

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.09661623
2Obstructive sleep apnea (HP:0002870)3.61057164
3Hyperacusis (HP:0010780)3.57745787
4Broad face (HP:0000283)3.20284233
5Eczematoid dermatitis (HP:0000976)3.18519059
6Cerebral aneurysm (HP:0004944)3.11519537
7Macroorchidism (HP:0000053)2.77942135
8Heterotopia (HP:0002282)2.64421389
9Disproportionate tall stature (HP:0001519)2.58103277
10Short 4th metacarpal (HP:0010044)2.57226807
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.57226807
12Increased IgE level (HP:0003212)2.50839165
13Pointed chin (HP:0000307)2.50021971
14Prominent nose (HP:0000448)2.49160762
15Long eyelashes (HP:0000527)2.49062151
16Flat acetabular roof (HP:0003180)2.46257167
17Insomnia (HP:0100785)2.43352862
18Broad palm (HP:0001169)2.40983669
19Metaphyseal cupping (HP:0003021)2.30517254
20Protrusio acetabuli (HP:0003179)2.28995037
21Elfin facies (HP:0004428)2.27585421
22Basal cell carcinoma (HP:0002671)2.22929883
23Increased nuchal translucency (HP:0010880)2.18269195
24Urethral obstruction (HP:0000796)2.17967533
25Aortic aneurysm (HP:0004942)2.15438578
26IgM deficiency (HP:0002850)2.14232953
27Renovascular hypertension (HP:0100817)2.14036843
28High pitched voice (HP:0001620)2.13931225
29Hemorrhage of the eye (HP:0011885)2.13698183
30Trigonocephaly (HP:0000243)2.12561089
31Thrombocytosis (HP:0001894)2.11010041
32Bowel diverticulosis (HP:0005222)2.10225093
33Deep venous thrombosis (HP:0002625)2.09805026
34Narrow palate (HP:0000189)2.09738970
35Renal duplication (HP:0000075)2.06996420
36Abnormality of the radial head (HP:0003995)2.04683596
37Thin bony cortex (HP:0002753)2.01647450
38Segmental peripheral demyelination/remyelination (HP:0003481)1.99540370
39Ependymoma (HP:0002888)1.98275301
40Asymmetry of the thorax (HP:0001555)1.97344070
41Acute lymphatic leukemia (HP:0006721)1.94784046
42Abnormal gallbladder physiology (HP:0012438)1.93905471
43Cholecystitis (HP:0001082)1.93905471
44Increased density of long bones (HP:0006392)1.93752838
45Gastrointestinal infarctions (HP:0005244)1.93149355
46Absent frontal sinuses (HP:0002688)1.92783305
47Abnormality of oral frenula (HP:0000190)1.92583578
48Gingivitis (HP:0000230)1.92348211
49Shallow orbits (HP:0000586)1.91113089
50Recurrent bronchitis (HP:0002837)1.90998856
51Obsessive-compulsive behavior (HP:0000722)1.90100468
52Bowel incontinence (HP:0002607)1.89215292
53Fatigue (HP:0012378)1.88496141
54Gastrointestinal inflammation (HP:0004386)1.88236714
55Myositis (HP:0100614)1.87191248
56Recurrent abscess formation (HP:0002722)1.86130806
57Biconcave vertebral bodies (HP:0004586)1.86016336
58Recurrent viral infections (HP:0004429)1.85923568
59Cellulitis (HP:0100658)1.85405755
60Colitis (HP:0002583)1.85222493
61Abnormal delayed hypersensitivity skin test (HP:0002963)1.85080075
62Polygenic inheritance (HP:0010982)1.84242055
63Increased connective tissue (HP:0009025)1.84102759
64Distal upper limb amyotrophy (HP:0007149)1.84060600
65Upper limb amyotrophy (HP:0009129)1.84060600
66Abnormality of the astrocytes (HP:0100707)1.83831549
67Astrocytoma (HP:0009592)1.83831549
68Genu recurvatum (HP:0002816)1.83265013
69Supranuclear gaze palsy (HP:0000605)1.83215887
70Abnormality of the lower motor neuron (HP:0002366)1.83116948
71Premature skin wrinkling (HP:0100678)1.82662283
72Selective tooth agenesis (HP:0001592)1.81742486
73Vertebral arch anomaly (HP:0008438)1.80308640
74Overriding aorta (HP:0002623)1.80214211
75Hand muscle atrophy (HP:0009130)1.79631595
76Recurrent gram-negative bacterial infections (HP:0005420)1.78799071
77Long palpebral fissure (HP:0000637)1.78252873
78Atelectasis (HP:0100750)1.78218423
79Enlarged penis (HP:0000040)1.77951789
80Abnormality of the thoracic spine (HP:0100711)1.77298187
81Subacute progressive viral hepatitis (HP:0006572)1.76718032
82Abnormality of the 4th metacarpal (HP:0010012)1.76658304
83Abnormality of macrophages (HP:0004311)1.76393159
84Cervical subluxation (HP:0003308)1.76273448
85Neoplasm of the oral cavity (HP:0100649)1.76025670
86Abnormality of the distal phalanx of the thumb (HP:0009617)1.75206084
87Aneurysm (HP:0002617)1.74989992
88Slow saccadic eye movements (HP:0000514)1.74466711
89Dilatation of the ascending aorta (HP:0005111)1.74435402
90Increased variability in muscle fiber diameter (HP:0003557)1.73718067
91Ankle contracture (HP:0006466)1.73673957
92Inflammation of the large intestine (HP:0002037)1.73527309
93Cafe-au-lait spot (HP:0000957)1.73378113
94Acute myeloid leukemia (HP:0004808)1.72937045
95Thin ribs (HP:0000883)1.72906374
96Ankyloglossia (HP:0010296)1.72270753
97Flat cornea (HP:0007720)1.71750013
98Myelodysplasia (HP:0002863)1.71636188
99Peripheral hypomyelination (HP:0007182)1.71402588
100Thoracic kyphosis (HP:0002942)1.70815508
101Bicuspid aortic valve (HP:0001647)1.70742286
102Sandal gap (HP:0001852)1.70420040
103Centrally nucleated skeletal muscle fibers (HP:0003687)1.69542628
104Prolonged bleeding time (HP:0003010)1.69301781
105Interstitial pulmonary disease (HP:0006530)1.69232356
106Bronchomalacia (HP:0002780)1.69015064
107Abnormal large intestine physiology (HP:0012700)1.68591269
108Skin tags (HP:0010609)1.68031993
109Dysmetric saccades (HP:0000641)1.67720545
110Annular pancreas (HP:0001734)1.67649084
111Supernumerary ribs (HP:0005815)1.67406629
112Verrucae (HP:0200043)1.67401217
113Papilloma (HP:0012740)1.67401217
114Cutaneous melanoma (HP:0012056)1.65895913
115Spontaneous hematomas (HP:0007420)1.65848449
116Abnormal vertebral ossification (HP:0100569)1.65621657
117Amaurosis fugax (HP:0100576)1.65362598
118Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.65049125
119Recurrent bacterial skin infections (HP:0005406)1.64951613
120Deep palmar crease (HP:0006191)1.64509360
121Onion bulb formation (HP:0003383)1.63894576
122Chest pain (HP:0100749)1.63764823
123Panhypogammaglobulinemia (HP:0003139)1.63214100
124Facial hemangioma (HP:0000329)1.63135122
125Autoimmune thrombocytopenia (HP:0001973)1.63052708
126Spinal muscular atrophy (HP:0007269)1.62801870
127Germ cell neoplasia (HP:0100728)1.62399284
128Radial bowing (HP:0002986)1.62384186
129Mitral regurgitation (HP:0001653)1.62193475
130Nasal polyposis (HP:0100582)1.61903719
131Stridor (HP:0010307)1.61663642
132Truncal obesity (HP:0001956)1.61658769
133Hemiplegia (HP:0002301)1.61609289
134Medulloblastoma (HP:0002885)1.60799252
135Deviation of the thumb (HP:0009603)1.60533004
136Spinal cord lesions (HP:0100561)1.60491161
137Syringomyelia (HP:0003396)1.60491161
138Recurrent fungal infections (HP:0002841)1.60046579
139Frequent falls (HP:0002359)1.59733882
140Arnold-Chiari malformation (HP:0002308)1.59726818
141Mitral valve prolapse (HP:0001634)1.58876816
142Distal lower limb amyotrophy (HP:0008944)1.58567326
143Supernumerary nipples (HP:0002558)1.58438047
144Reticulocytosis (HP:0001923)1.58208541
145Truncus arteriosus (HP:0001660)1.58102356
146Striae distensae (HP:0001065)1.57709253
147Lymphangioma (HP:0100764)1.57639096
148Volvulus (HP:0002580)1.57489732
149Ulnar bowing (HP:0003031)1.57407522
150Broad thumb (HP:0011304)1.56868046
151Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.56708576
152Chronic obstructive pulmonary disease (HP:0006510)1.56674533
153Obstructive lung disease (HP:0006536)1.56674533
154Proximal placement of thumb (HP:0009623)1.56517264
155Hypochromic anemia (HP:0001931)1.56506330
156Abnormality of the columella (HP:0009929)1.56283694
157Blue sclerae (HP:0000592)1.55422319
158Ureteral stenosis (HP:0000071)1.54623968
159Emphysema (HP:0002097)1.54474121
160Dislocated radial head (HP:0003083)1.53794662
161Meningitis (HP:0001287)1.53738600
162Lower limb amyotrophy (HP:0007210)1.53345177
163Joint laxity (HP:0001388)1.52643499
164Viral hepatitis (HP:0006562)1.52501126

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.32088138
2CDK123.97051037
3TRIB33.92512445
4SMG13.37424959
5PRPF4B3.25503525
6MAP3K103.25435245
7MAP4K13.16620086
8PKN23.08946816
9BRD42.82274152
10SIK22.58480205
11RIPK42.09563182
12CDC72.07472651
13TAOK11.86495947
14SCYL21.77845163
15NEK21.73718176
16RIPK11.66404823
17CAMK1D1.50443609
18MAP2K31.46581554
19CAMK1G1.46126529
20JAK31.43316761
21EPHB11.41401968
22PTK61.38588318
23ALK1.38231094
24TTN1.35677095
25ZAP701.27536912
26CDK41.21992389
27STK101.21361495
28MTOR1.18057897
29SIK11.16814667
30PRKD31.13405043
31KIT1.12408562
32PASK1.09033160
33PDGFRA1.07813233
34PRKCH1.06030546
35MAP3K61.05540983
36MARK21.03771842
37ICK1.02290658
38PRKD20.99780290
39MAP3K70.99070985
40FGFR30.98527321
41MAP3K130.95582057
42HCK0.92930330
43MAP3K10.92337110
44SGK30.91602028
45CDK90.91598451
46CSF1R0.88572489
47TYRO30.88110031
48ERN10.87824104
49PDPK10.87100483
50LRRK20.84816560
51MAP3K90.84471030
52BTK0.84440647
53RET0.84361578
54CDK60.83466429
55JAK10.83349241
56SYK0.83171325
57GRK60.82395762
58CAMKK10.82222293
59MAPK110.80315257
60TYK20.80285440
61ATR0.80049803
62PAK40.79902419
63PDGFRB0.79549356
64CSK0.79507228
65FGFR40.78613097
66PDK10.78309682
67RPS6KB20.76381733
68ITK0.75932070
69DMPK0.72939686
70KSR20.71643181
71PAK20.71307205
72MAP3K110.71185299
73MAPK120.70852198
74CHEK10.70781850
75IRAK40.70622565
76TAOK30.70397798
77CHUK0.69776813
78MAP3K20.69470819
79RPS6KC10.68682676
80RPS6KL10.68682676
81CDC42BPA0.64936370
82NTRK10.64601070
83FLT30.61809033
84MAP3K80.60310326
85BLK0.59342073
86NTRK20.58913419
87CDK20.58068774
88STK40.56609280
89MAP3K30.56477569
90FGFR20.56359141
91CDK70.56291338
92FES0.55387584
93LCK0.55101077
94DAPK10.53295526
95STK380.53191485
96KSR10.52444690
97PIM10.52141802
98SIK30.51519589
99PTK20.51164138
100MAP2K20.50405360
101LATS10.50236290
102CLK10.49020966
103IKBKE0.48439083
104RPS6KA60.48341516
105TBK10.47899255
106TAOK20.47698470
107FGR0.47396314
108RPS6KA20.46987027
109JAK20.46777734
110MAP3K140.45790865
111STK110.45345572
112MARK30.44358822
113TNK20.43764647
114MAPK100.43528826
115EPHA30.42587071
116ATM0.42433915
117HIPK20.42222217
118MAPK70.41645416
119CAMK40.41335493
120WNK10.40973217
121TSSK60.40868270
122SGK20.40694991
123TGFBR20.40459692
124RAF10.40370405
125TGFBR10.40369055
126BMX0.40349273
127DYRK1B0.40151662
128MAPK140.38780267
129FYN0.37907944
130RPS6KA10.37617440
131NTRK30.35948447
132YES10.32752096
133MAPK80.32325752

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.03517840
2Other glycan degradation_Homo sapiens_hsa005111.98390643
3Chronic myeloid leukemia_Homo sapiens_hsa052201.81473236
4B cell receptor signaling pathway_Homo sapiens_hsa046621.73685105
5Primary immunodeficiency_Homo sapiens_hsa053401.61802268
6Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.53577764
7Non-small cell lung cancer_Homo sapiens_hsa052231.49296439
8T cell receptor signaling pathway_Homo sapiens_hsa046601.46456206
9Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.44297424
10Neurotrophin signaling pathway_Homo sapiens_hsa047221.41059584
11mTOR signaling pathway_Homo sapiens_hsa041501.40896175
12Lysine degradation_Homo sapiens_hsa003101.35841293
13Notch signaling pathway_Homo sapiens_hsa043301.35442469
14Acute myeloid leukemia_Homo sapiens_hsa052211.34551936
15Thyroid hormone signaling pathway_Homo sapiens_hsa049191.34196284
16Pancreatic cancer_Homo sapiens_hsa052121.28517198
17mRNA surveillance pathway_Homo sapiens_hsa030151.28376225
18DNA replication_Homo sapiens_hsa030301.25774638
19Osteoclast differentiation_Homo sapiens_hsa043801.24666944
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24088940
21Thyroid cancer_Homo sapiens_hsa052161.23044264
22Glioma_Homo sapiens_hsa052141.22698896
23Small cell lung cancer_Homo sapiens_hsa052221.18421740
24Colorectal cancer_Homo sapiens_hsa052101.16570553
25Endometrial cancer_Homo sapiens_hsa052131.16389506
26HTLV-I infection_Homo sapiens_hsa051661.15931083
27Cell cycle_Homo sapiens_hsa041101.15643509
28MicroRNAs in cancer_Homo sapiens_hsa052061.15469359
29VEGF signaling pathway_Homo sapiens_hsa043701.15019250
30Measles_Homo sapiens_hsa051621.14053993
31Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12281852
32Type II diabetes mellitus_Homo sapiens_hsa049301.09973533
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08452703
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08248913
35Platelet activation_Homo sapiens_hsa046111.08040122
36Leishmaniasis_Homo sapiens_hsa051401.03956662
37Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03820440
38Herpes simplex infection_Homo sapiens_hsa051681.02476214
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01782557
40Hepatitis B_Homo sapiens_hsa051611.01757216
41Toxoplasmosis_Homo sapiens_hsa051451.00904503
42Prolactin signaling pathway_Homo sapiens_hsa049171.00178866
43Viral myocarditis_Homo sapiens_hsa054160.99465731
44Mismatch repair_Homo sapiens_hsa034300.99234570
45NF-kappa B signaling pathway_Homo sapiens_hsa040640.98733912
46Chemokine signaling pathway_Homo sapiens_hsa040620.95959198
47Dorso-ventral axis formation_Homo sapiens_hsa043200.95412687
48Antigen processing and presentation_Homo sapiens_hsa046120.94112823
49Base excision repair_Homo sapiens_hsa034100.93909785
50Influenza A_Homo sapiens_hsa051640.92224107
51Hepatitis C_Homo sapiens_hsa051600.92202965
52Viral carcinogenesis_Homo sapiens_hsa052030.92129934
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91799215
54Estrogen signaling pathway_Homo sapiens_hsa049150.89204208
55Apoptosis_Homo sapiens_hsa042100.88676467
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88274515
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.88019541
58Proteoglycans in cancer_Homo sapiens_hsa052050.87787159
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86823586
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.86551917
61Spliceosome_Homo sapiens_hsa030400.86120590
62Insulin resistance_Homo sapiens_hsa049310.85496491
63Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85451419
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.85022776
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.84703539
66RNA transport_Homo sapiens_hsa030130.84257185
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.83906975
68Prion diseases_Homo sapiens_hsa050200.83617973
69Focal adhesion_Homo sapiens_hsa045100.82355284
70Inositol phosphate metabolism_Homo sapiens_hsa005620.82141083
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81485416
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81139119
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81005805
74Shigellosis_Homo sapiens_hsa051310.80138675
75Amoebiasis_Homo sapiens_hsa051460.79043532
76Hematopoietic cell lineage_Homo sapiens_hsa046400.78067418
77Long-term potentiation_Homo sapiens_hsa047200.77530888
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.77077005
79Oocyte meiosis_Homo sapiens_hsa041140.76791830
80Renal cell carcinoma_Homo sapiens_hsa052110.76395716
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75194776
82Fructose and mannose metabolism_Homo sapiens_hsa000510.74910162
83FoxO signaling pathway_Homo sapiens_hsa040680.74861510
84ErbB signaling pathway_Homo sapiens_hsa040120.74158284
85Epstein-Barr virus infection_Homo sapiens_hsa051690.74086994
86GnRH signaling pathway_Homo sapiens_hsa049120.73712739
87AMPK signaling pathway_Homo sapiens_hsa041520.73505233
88MAPK signaling pathway_Homo sapiens_hsa040100.73494702
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73411918
90Choline metabolism in cancer_Homo sapiens_hsa052310.73033620
91Adherens junction_Homo sapiens_hsa045200.71945064
92p53 signaling pathway_Homo sapiens_hsa041150.71205776
93HIF-1 signaling pathway_Homo sapiens_hsa040660.70977862
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70817645
95TNF signaling pathway_Homo sapiens_hsa046680.70589729
96Pentose phosphate pathway_Homo sapiens_hsa000300.70164661
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69864644
98Insulin signaling pathway_Homo sapiens_hsa049100.69850739
99Olfactory transduction_Homo sapiens_hsa047400.69618613
100Tuberculosis_Homo sapiens_hsa051520.68994112
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68734990
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67376409
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.67364042
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65843932
105Rap1 signaling pathway_Homo sapiens_hsa040150.64780263
106Oxytocin signaling pathway_Homo sapiens_hsa049210.64556862
107Endocytosis_Homo sapiens_hsa041440.63224801
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63030399
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.62814536
110Pathways in cancer_Homo sapiens_hsa052000.61938024
111Prostate cancer_Homo sapiens_hsa052150.60515965
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.60253618
113Staphylococcus aureus infection_Homo sapiens_hsa051500.59902182
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59411599
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58782002
116Melanogenesis_Homo sapiens_hsa049160.58643510
117Non-homologous end-joining_Homo sapiens_hsa034500.58632016
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58386399
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.58349517
120Bladder cancer_Homo sapiens_hsa052190.58048606
121Thyroid hormone synthesis_Homo sapiens_hsa049180.54613415
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51405413
123Glucagon signaling pathway_Homo sapiens_hsa049220.47076518

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