CABLES1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pigment cell differentiation (GO:0050931)4.88811705
2sodium ion export (GO:0071436)4.58203232
3tyrosine metabolic process (GO:0006570)4.50561959
4synaptic vesicle docking involved in exocytosis (GO:0016081)4.23721504
5cellular potassium ion homeostasis (GO:0030007)4.23604409
6vitamin transmembrane transport (GO:0035461)4.12920877
7regulation of guanylate cyclase activity (GO:0031282)4.04361077
8phenol-containing compound biosynthetic process (GO:0046189)3.92510470
9protein localization to endosome (GO:0036010)3.90094698
10regulation of early endosome to late endosome transport (GO:2000641)3.78526381
11cytoskeletal anchoring at plasma membrane (GO:0007016)3.72827903
12regulation of mammary gland epithelial cell proliferation (GO:0033599)3.70601141
13gonadal mesoderm development (GO:0007506)3.67373253
14basement membrane organization (GO:0071711)3.59098759
15macrophage chemotaxis (GO:0048246)3.56700990
16low-density lipoprotein particle clearance (GO:0034383)3.53998027
17proline biosynthetic process (GO:0006561)3.48297446
18cellular ketone body metabolic process (GO:0046950)3.46520733
19adherens junction assembly (GO:0034333)3.37769215
20pigment biosynthetic process (GO:0046148)3.37321825
21regulation of ARF GTPase activity (GO:0032312)3.36536815
22negative regulation of cAMP-mediated signaling (GO:0043951)3.33989904
23Golgi transport vesicle coating (GO:0048200)3.29456543
24COPI coating of Golgi vesicle (GO:0048205)3.29456543
25response to muramyl dipeptide (GO:0032495)3.22683410
26secondary metabolic process (GO:0019748)3.21184694
27positive regulation of guanylate cyclase activity (GO:0031284)3.18234068
28filopodium assembly (GO:0046847)3.16225667
29cyclooxygenase pathway (GO:0019371)3.10978830
30maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.10059417
31cellular protein complex localization (GO:0034629)3.05548576
32protein retention in ER lumen (GO:0006621)3.04066243
33cellular sodium ion homeostasis (GO:0006883)3.04012557
34receptor catabolic process (GO:0032801)3.02030251
35G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.01398866
36amino acid import (GO:0043090)3.00489631
37cell-substrate adherens junction assembly (GO:0007045)3.00295255
38focal adhesion assembly (GO:0048041)3.00295255
39adenosine receptor signaling pathway (GO:0001973)2.97877659
40chondroitin sulfate catabolic process (GO:0030207)2.96116352
41protein complex localization (GO:0031503)2.92925843
42semaphorin-plexin signaling pathway (GO:0071526)2.92708164
43relaxation of cardiac muscle (GO:0055119)2.92529445
44cellular response to nitric oxide (GO:0071732)2.92419779
45retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.90526425
46negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.90525672
47ketone body metabolic process (GO:1902224)2.90328016
48neuroepithelial cell differentiation (GO:0060563)2.89892204
49gamma-aminobutyric acid transport (GO:0015812)2.88619283
50negative regulation of tissue remodeling (GO:0034104)2.87879965
51regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.86750032
52protein targeting to Golgi (GO:0000042)2.85637620
53hemidesmosome assembly (GO:0031581)2.84967578
54L-serine transport (GO:0015825)2.84622561
55protein maturation by protein folding (GO:0022417)2.83447438
56proline metabolic process (GO:0006560)2.80685291
57potassium ion homeostasis (GO:0055075)2.78998788
58cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.78456729
59alanine transport (GO:0032328)2.78416550
60microglial cell activation (GO:0001774)2.78313048
61potassium ion import (GO:0010107)2.77805156
62negative regulation of fatty acid transport (GO:2000192)2.77304383
63monocyte differentiation (GO:0030224)2.77218716
64regulation of glucose import in response to insulin stimulus (GO:2001273)2.76364467
65negative regulation of sodium ion transport (GO:0010766)2.73044080
66retrograde transport, vesicle recycling within Golgi (GO:0000301)2.72835519
67apoptotic cell clearance (GO:0043277)2.71930607
68tolerance induction (GO:0002507)2.71486027
69regulation of cGMP biosynthetic process (GO:0030826)2.71134075
70positive regulation of triglyceride biosynthetic process (GO:0010867)2.70890040
71regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.70104401
72negative regulation of cell killing (GO:0031342)2.69971627
73negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.69971627
74endothelium development (GO:0003158)2.69912944
75positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.69302281
76cellular response to reactive nitrogen species (GO:1902170)2.68802541
77G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.67401618
78establishment of protein localization to Golgi (GO:0072600)2.66651996
79activation of protein kinase A activity (GO:0034199)2.66444782
80pigment metabolic process (GO:0042440)2.65140147
81positive regulation of tolerance induction (GO:0002645)2.64820048
82cell communication by electrical coupling (GO:0010644)2.64489045
83activation of Rac GTPase activity (GO:0032863)2.63960796
84negative regulation of adherens junction organization (GO:1903392)2.60921769
85negative regulation of focal adhesion assembly (GO:0051895)2.60921769
86negative regulation of cell junction assembly (GO:1901889)2.60921769
87pigment granule organization (GO:0048753)2.59208140
88negative regulation of granulocyte differentiation (GO:0030853)2.59197551
89activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.58653190
90neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.58585335
91mating behavior (GO:0007617)2.57711988
92regulation of T cell tolerance induction (GO:0002664)2.55570602
93mitotic G1 DNA damage checkpoint (GO:0031571)2.54751478
94negative regulation of cell size (GO:0045792)2.54696022
95pyrimidine-containing compound transmembrane transport (GO:0072531)2.53251650
96diacylglycerol metabolic process (GO:0046339)2.53123891
97bile acid and bile salt transport (GO:0015721)2.52904046
98melanosome organization (GO:0032438)2.52852069
99regulation of triglyceride biosynthetic process (GO:0010866)2.52234718
100vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.51733791
101natural killer cell differentiation (GO:0001779)2.51508456
102regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.50128130
103positive regulation of nuclease activity (GO:0032075)2.49812297
104serine transport (GO:0032329)2.49703343
105negative regulation of dendrite morphogenesis (GO:0050774)2.48988965
106regulation of cholesterol homeostasis (GO:2000188)2.48240700
107insulin-like growth factor receptor signaling pathway (GO:0048009)2.47238985
108coenzyme A biosynthetic process (GO:0015937)2.47176584
109positive regulation of glycoprotein biosynthetic process (GO:0010560)2.45963750
110cardiac muscle hypertrophy in response to stress (GO:0014898)2.45316702
111muscle hypertrophy in response to stress (GO:0003299)2.45316702
112cardiac muscle adaptation (GO:0014887)2.45316702
113negative regulation of cyclase activity (GO:0031280)2.43689371
114negative regulation of erythrocyte differentiation (GO:0045647)2.43442098
115synaptic vesicle maturation (GO:0016188)2.43342331
116lamellipodium organization (GO:0097581)2.42426751
117urea cycle (GO:0000050)2.41677625
118barbed-end actin filament capping (GO:0051016)2.40295186
119cGMP-mediated signaling (GO:0019934)2.40228462
120positive regulation of chemokine secretion (GO:0090197)2.39442607
121positive regulation of p38MAPK cascade (GO:1900745)2.39166211
122pinocytosis (GO:0006907)2.39086070
123regulation of cholesterol biosynthetic process (GO:0045540)2.38681886
124positive regulation of DNA-dependent DNA replication (GO:2000105)2.38510509
125L-amino acid import (GO:0043092)2.37924794
126biotin metabolic process (GO:0006768)2.37058383
127positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.35653043
128regulation of cardiac muscle cell contraction (GO:0086004)2.35569548
129negative regulation of bone resorption (GO:0045779)2.34754792
130mitotic chromosome condensation (GO:0007076)2.34070906
131regulation of p38MAPK cascade (GO:1900744)2.33681678
132G1 DNA damage checkpoint (GO:0044783)2.33035334
133regulation of translational fidelity (GO:0006450)2.32276176
134cell volume homeostasis (GO:0006884)2.31650115
135purine nucleotide transport (GO:0015865)2.31102635
136CDP-diacylglycerol metabolic process (GO:0046341)2.30856375
137regulation of short-term neuronal synaptic plasticity (GO:0048172)2.30738185
138NADH metabolic process (GO:0006734)2.30365781
139neuromuscular process controlling balance (GO:0050885)2.30291526
140alpha-linolenic acid metabolic process (GO:0036109)2.29934944
141regulation of neuronal synaptic plasticity (GO:0048168)2.29553920
142synaptic vesicle exocytosis (GO:0016079)2.28460883
143regulation of tolerance induction (GO:0002643)2.28445571
144white fat cell differentiation (GO:0050872)2.27989864
145locomotory exploration behavior (GO:0035641)2.27608127
146epithelial cell-cell adhesion (GO:0090136)2.26784471
147regulation of synaptic vesicle exocytosis (GO:2000300)2.26665825
148protein localization to cell surface (GO:0034394)2.26566052
149endoplasmic reticulum unfolded protein response (GO:0030968)2.26173896
150triglyceride catabolic process (GO:0019433)2.26173242
151bone resorption (GO:0045453)2.25984342
152maternal placenta development (GO:0001893)2.25493872
153fatty acid homeostasis (GO:0055089)2.25318835
154regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.24745412
155positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.24745412
156urea metabolic process (GO:0019627)2.24405779
157regulation of cGMP metabolic process (GO:0030823)2.23739169
158cerebellar Purkinje cell layer development (GO:0021680)2.23690135
159endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.23609849
160melanocyte differentiation (GO:0030318)2.23359748
161layer formation in cerebral cortex (GO:0021819)2.22884061
162regulation of nuclease activity (GO:0032069)2.22520663
163regulation of synapse structural plasticity (GO:0051823)2.22299693
164adenine nucleotide transport (GO:0051503)2.22181744
165neutral lipid catabolic process (GO:0046461)2.22020742
166acylglycerol catabolic process (GO:0046464)2.22020742
167positive regulation of glycoprotein metabolic process (GO:1903020)2.21967467
168positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.21815580
169glutamate secretion (GO:0014047)2.21612910
170stress fiber assembly (GO:0043149)2.21149479
171negative regulation of lyase activity (GO:0051350)2.18663328
172positive regulation of Rac GTPase activity (GO:0032855)2.18308631
173proline transport (GO:0015824)2.18049967
174brown fat cell differentiation (GO:0050873)2.17918941
175adaptation of signaling pathway (GO:0023058)2.17200286
176positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.15267562
177negative regulation of cytosolic calcium ion concentration (GO:0051481)2.15149333
178response to auditory stimulus (GO:0010996)2.14448434
179positive regulation of fatty acid oxidation (GO:0046321)2.14394192
180membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.13769482
181negative regulation of multicellular organism growth (GO:0040015)2.13286901
182pantothenate metabolic process (GO:0015939)2.12915907
183mannose metabolic process (GO:0006013)2.12781776
184positive regulation of cGMP biosynthetic process (GO:0030828)2.12634246
185cell communication involved in cardiac conduction (GO:0086065)2.12340956
186purinergic receptor signaling pathway (GO:0035587)2.11896325
187melanin biosynthetic process (GO:0042438)12.6637925
188melanin metabolic process (GO:0006582)11.9357145
189secondary metabolite biosynthetic process (GO:0044550)10.1936809

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.44742912
2E2F7_22180533_ChIP-Seq_HELA_Human2.99618616
3IKZF1_21737484_ChIP-ChIP_HCT116_Human2.85070914
4DROSHA_22980978_ChIP-Seq_HELA_Human2.80120939
5ZNF263_19887448_ChIP-Seq_K562_Human2.67034940
6MYC_22102868_ChIP-Seq_BL_Human2.17178067
7ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.09774812
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.03270653
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99647614
10NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90927067
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.90744300
12CLOCK_20551151_ChIP-Seq_293T_Human1.89691008
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.84673893
14ESR2_21235772_ChIP-Seq_MCF-7_Human1.84001811
15AR_21572438_ChIP-Seq_LNCaP_Human1.77797437
16CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77720658
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73344256
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72949473
19RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.71083690
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70950692
21ERG_21242973_ChIP-ChIP_JURKAT_Human1.70830961
22* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69791288
23P300_27058665_Chip-Seq_ZR-75-30cells_Human1.69476457
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.69089738
25* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68339611
26* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63113511
27ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.61816741
28SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.61754751
29* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.61594171
30* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.60762245
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.59412129
32* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59044272
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.56920673
34* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56436982
35TP63_17297297_ChIP-ChIP_HaCaT_Human1.56349047
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.55834177
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55480649
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54813337
39* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.54048070
40* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.54048070
41TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.53680953
42CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.49915331
43* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49475803
44CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48776585
45KDM2B_26808549_Chip-Seq_K562_Human1.46226678
46* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.46076920
47* EZH2_27294783_Chip-Seq_ESCs_Mouse1.45855315
48* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.45396444
49* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43363402
50MYC_18555785_ChIP-Seq_MESCs_Mouse1.42503363
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42347803
52* MITF_21258399_ChIP-Seq_MELANOMA_Human1.39780789
53* LXR_22292898_ChIP-Seq_THP-1_Human1.38948009
54SCL_19346495_ChIP-Seq_HPC-7_Human1.37086102
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36833422
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36456945
57DNAJC2_21179169_ChIP-ChIP_NT2_Human1.36216474
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.36046740
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35563403
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34904589
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.34364452
62AR_21909140_ChIP-Seq_LNCAP_Human1.34202850
63KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33647954
64* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.32181905
65MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31513419
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30503127
67DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.30057129
68* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29058426
69ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29049675
70SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27851779
71KDM2B_26808549_Chip-Seq_DND41_Human1.27732502
72EED_16625203_ChIP-ChIP_MESCs_Mouse1.27520661
73RXR_22108803_ChIP-Seq_LS180_Human1.27199961
74SMC4_20622854_ChIP-Seq_HELA_Human1.26789847
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26337549
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.26221433
77* RARB_27405468_Chip-Seq_BRAIN_Mouse1.24197748
78ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24126958
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21774167
80CDX2_20551321_ChIP-Seq_CACO-2_Human1.21127776
81VDR_21846776_ChIP-Seq_THP-1_Human1.20404538
82* CREB1_26743006_Chip-Seq_LNCaP_Human1.19578210
83CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19058739
84* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18328827
85TET1_21490601_ChIP-Seq_MESCs_Mouse1.18184813
86SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18066662
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17699750
88ESR1_20079471_ChIP-ChIP_T-47D_Human1.16690372
89* RNF2_27304074_Chip-Seq_ESCs_Mouse1.16251001
90ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.16157339
91TCF7_22412390_ChIP-Seq_EML_Mouse1.16121377
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16006554
93RUNX_20019798_ChIP-Seq_JUKART_Human1.15875872
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15799071
95CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15750475
96FOXO3_23340844_ChIP-Seq_DLD1_Human1.14762025
97GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.14377055
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14159764
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14001354
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13954431
101EZH2_22144423_ChIP-Seq_EOC_Human1.13584414
102* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12589953
103* UBF1/2_26484160_Chip-Seq_HMECs_Human1.12472452
104RXR_22158963_ChIP-Seq_LIVER_Mouse1.12362399
105SPI1_23127762_ChIP-Seq_K562_Human1.12036361
106VDR_24787735_ChIP-Seq_THP-1_Human1.11419869
107ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11081251
108PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10127818
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09921761
110P68_20966046_ChIP-Seq_HELA_Human1.09473205
111PPARA_22158963_ChIP-Seq_LIVER_Mouse1.09036593
112TBX20_22328084_ChIP-Seq_HEART_Mouse1.08846859
113TBX20_22080862_ChIP-Seq_HEART_Mouse1.08846859
114POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08096940
115GATA2_21666600_ChIP-Seq_HMVEC_Human1.08063139
116GATA1_19941826_ChIP-Seq_K562_Human1.08043251
117SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07670564
118NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07417990
119ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07383606
120ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06451499
121ATF3_27146783_Chip-Seq_COLON_Human1.05537394
122TP53_16413492_ChIP-PET_HCT116_Human1.02633851
123RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02338531
124SMAD_19615063_ChIP-ChIP_OVARY_Human1.02322875
125SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01934528
126NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01686603
127E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01567753
128SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01412405
129TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01336404
130HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01043369
131MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00909590
132* LXR_22158963_ChIP-Seq_LIVER_Mouse1.00090668
133GATA2_19941826_ChIP-Seq_K562_Human0.99530074
134ELK3_25401928_ChIP-Seq_HUVEC_Human0.99425854
135EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98413408
136GBX2_23144817_ChIP-Seq_PC3_Human0.98237219
137SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98023341
138* RACK7_27058665_Chip-Seq_MCF-7_Human0.97807978
139GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97762164
140TFEB_21752829_ChIP-Seq_HELA_Human0.97429092
141SMAD3_21741376_ChIP-Seq_HESCs_Human0.97374747
142CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97098926
143* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96729623
144RUNX1_27514584_Chip-Seq_MCF-7_Human0.96715213
145* SA1_27219007_Chip-Seq_ERYTHROID_Human0.95034465
146CTCF_27219007_Chip-Seq_Bcells_Human0.93990910
147* VDR_24763502_ChIP-Seq_THP-1_Human0.92980852
148BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92498827
149ESR1_21235772_ChIP-Seq_MCF-7_Human0.91615784
150KLF5_25053715_ChIP-Seq_YYC3_Human0.90947621
151STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.90770045
152ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89758733
153* ARNT_22903824_ChIP-Seq_MCF-7_Human0.88838268
154FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.88680506
155KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88543606
156* AHR_22903824_ChIP-Seq_MCF-7_Human0.87758483
157NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87655437
158REST_18959480_ChIP-ChIP_MESCs_Mouse0.87296952
159KDM2B_26808549_Chip-Seq_JURKAT_Human0.86616422
160BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86553235
161PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84302411
162AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83599825
163SMAD4_21741376_ChIP-Seq_HESCs_Human0.83216047
164KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82387874

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation7.45823780
2MP0003136_yellow_coat_color6.24399940
3MP0000372_irregular_coat_pigmentation6.16464002
4MP0005408_hypopigmentation4.19846124
5MP0000015_abnormal_ear_pigmentation4.16893402
6MP0005257_abnormal_intraocular_pressure4.13113633
7MP0002877_abnormal_melanocyte_morpholog4.02798724
8MP0003191_abnormal_cellular_cholesterol3.97042651
9MP0005409_darkened_coat_color3.43496716
10MP0005058_abnormal_lysosome_morphology3.23498853
11MP0003303_peritoneal_inflammation3.20299669
12MP0005377_hearing/vestibular/ear_phenot3.19154229
13MP0003878_abnormal_ear_physiology3.19154229
14MP0005075_abnormal_melanosome_morpholog3.01052066
15MP0003283_abnormal_digestive_organ2.96981733
16MP0004381_abnormal_hair_follicle2.96026458
17MP0005167_abnormal_blood-brain_barrier2.64184696
18MP0002254_reproductive_system_inflammat2.64044950
19MP0003300_gastrointestinal_ulcer2.60907602
20MP0003045_fibrosis2.57726936
21MP0004859_abnormal_synaptic_plasticity2.49955256
22MP0002822_catalepsy2.48965700
23MP0005666_abnormal_adipose_tissue2.36924569
24MP0005670_abnormal_white_adipose2.33784998
25MP0002095_abnormal_skin_pigmentation2.26812459
26MP0004130_abnormal_muscle_cell2.26648542
27MP0009384_cardiac_valve_regurgitation2.23993042
28MP0004885_abnormal_endolymph2.23732446
29MP0001873_stomach_inflammation2.18613456
30MP0002075_abnormal_coat/hair_pigmentati2.14095134
31MP0003075_altered_response_to2.13375817
32MP0003866_abnormal_defecation2.12392545
33MP0008438_abnormal_cutaneous_collagen2.11021311
34MP0005174_abnormal_tail_pigmentation2.08675360
35MP0004484_altered_response_of1.97765294
36MP0001440_abnormal_grooming_behavior1.79295857
37MP0003690_abnormal_glial_cell1.76559323
38MP0003724_increased_susceptibility_to1.76158701
39MP0001186_pigmentation_phenotype1.75640836
40MP0004185_abnormal_adipocyte_glucose1.73695669
41MP0004858_abnormal_nervous_system1.73632051
42MP0005623_abnormal_meninges_morphology1.68659651
43MP0005365_abnormal_bile_salt1.63611206
44MP0001324_abnormal_eye_pigmentation1.60970116
45MP0001501_abnormal_sleep_pattern1.59896064
46MP0001348_abnormal_lacrimal_gland1.58340841
47MP0003635_abnormal_synaptic_transmissio1.56913488
48MP0001502_abnormal_circadian_rhythm1.55314730
49MP0002971_abnormal_brown_adipose1.55197615
50MP0003252_abnormal_bile_duct1.51641032
51MP0010234_abnormal_vibrissa_follicle1.50851344
52MP0008004_abnormal_stomach_pH1.46987955
53MP0008961_abnormal_basal_metabolism1.45121775
54MP0005166_decreased_susceptibility_to1.43942093
55MP0000343_altered_response_to1.40026912
56MP0008875_abnormal_xenobiotic_pharmacok1.37027035
57MP0010155_abnormal_intestine_physiology1.33581578
58MP0005375_adipose_tissue_phenotype1.31188327
59MP0010329_abnormal_lipoprotein_level1.31187130
60MP0002064_seizures1.30807326
61MP0009046_muscle_twitch1.29703880
62MP0001346_abnormal_lacrimal_gland1.29459341
63MP0004270_analgesia1.28791534
64MP0005671_abnormal_response_to1.28372751
65MP0004272_abnormal_basement_membrane1.28138761
66MP0008874_decreased_physiological_sensi1.26936359
67MP0000569_abnormal_digit_pigmentation1.26699226
68MP0003633_abnormal_nervous_system1.24262531
69MP0002090_abnormal_vision1.22363662
70MP0000465_gastrointestinal_hemorrhage1.22011828
71MP0004264_abnormal_extraembryonic_tissu1.18303298
72MP0001663_abnormal_digestive_system1.18079634
73MP0005464_abnormal_platelet_physiology1.16020119
74MP0002572_abnormal_emotion/affect_behav1.13797581
75MP0004233_abnormal_muscle_weight1.12694233
76MP0009745_abnormal_behavioral_response1.12499595
77MP0001664_abnormal_digestion1.10970938
78MP0009780_abnormal_chondrocyte_physiolo1.09639936
79MP0005197_abnormal_uvea_morphology1.09403713
80MP0003172_abnormal_lysosome_physiology1.09377930
81MP0001849_ear_inflammation1.07092579
82MP0008569_lethality_at_weaning1.06778994
83MP0006082_CNS_inflammation1.06685992
84MP0005085_abnormal_gallbladder_physiolo1.06065169
85MP0002736_abnormal_nociception_after1.05851848
86MP0004883_abnormal_blood_vessel1.05499826
87MP0002557_abnormal_social/conspecific_i1.04980700
88MP0003879_abnormal_hair_cell1.04903907
89MP0001486_abnormal_startle_reflex1.04686332
90MP0000371_diluted_coat_color1.04481569
91MP0000003_abnormal_adipose_tissue1.03704600
92MP0002909_abnormal_adrenal_gland1.03650349
93MP0002118_abnormal_lipid_homeostasis1.03071977
94MP0001970_abnormal_pain_threshold1.02922424
95MP0000013_abnormal_adipose_tissue1.02341481
96MP0005584_abnormal_enzyme/coenzyme_acti1.01004356
97MP0002063_abnormal_learning/memory/cond0.99106864
98MP0003111_abnormal_nucleus_morphology0.96675606
99MP0005076_abnormal_cell_differentiation0.95587577
100MP0001968_abnormal_touch/_nociception0.94757172
101MP0003123_paternal_imprinting0.92877022
102MP0002653_abnormal_ependyma_morphology0.89619761
103MP0005423_abnormal_somatic_nervous0.89300225
104MP0002938_white_spotting0.89172454
105MP0009672_abnormal_birth_weight0.88765054
106MP0006138_congestive_heart_failure0.88550219
107MP0005535_abnormal_body_temperature0.87393890
108MP0005165_increased_susceptibility_to0.85366651
109MP0000249_abnormal_blood_vessel0.85071143
110MP0003091_abnormal_cell_migration0.84609866
111MP0004782_abnormal_surfactant_physiolog0.83089908
112MP0003705_abnormal_hypodermis_morpholog0.82108297
113MP0003638_abnormal_response/metabolism_0.82098433
114MP0002166_altered_tumor_susceptibility0.81164069
115MP0005381_digestive/alimentary_phenotyp0.79282721
116MP0000230_abnormal_systemic_arterial0.76988446
117MP0008260_abnormal_autophagy0.76796048
118MP0002733_abnormal_thermal_nociception0.76100039
119MP0010030_abnormal_orbit_morphology0.74997832
120MP0000477_abnormal_intestine_morphology0.74264718
121MP0003566_abnormal_cell_adhesion0.73329625
122MP0009840_abnormal_foam_cell0.73139743
123MP0008873_increased_physiological_sensi0.70326460
124MP0002177_abnormal_outer_ear0.70132841
125MP0003453_abnormal_keratinocyte_physiol0.69525977
126MP0002089_abnormal_postnatal_growth/wei0.69256997
127MP0002734_abnormal_mechanical_nocicepti0.69163523
128MP0003634_abnormal_glial_cell0.68986445
129MP0004142_abnormal_muscle_tone0.68374302
130MP0000490_abnormal_crypts_of0.68372973
131MP0003329_amyloid_beta_deposits0.68199342
132MP0003868_abnormal_feces_composition0.65175392
133MP0001853_heart_inflammation0.63760610
134MP0008872_abnormal_physiological_respon0.63550923
135MP0005334_abnormal_fat_pad0.63450311
136MP0000920_abnormal_myelination0.63401548
137MP0010368_abnormal_lymphatic_system0.62441807
138MP0005508_abnormal_skeleton_morphology0.62215059
139MP0002272_abnormal_nervous_system0.61043775
140MP0001188_hyperpigmentation0.60882818
141MP0000350_abnormal_cell_proliferation0.60865950
142MP0001666_abnormal_nutrient_absorption0.60270882
143MP0003880_abnormal_central_pattern0.60248456
144MP0001177_atelectasis0.60160082
145MP0002970_abnormal_white_adipose0.59056049
146MP0002796_impaired_skin_barrier0.58536616
147MP0002060_abnormal_skin_morphology0.57630790
148MP0005621_abnormal_cell_physiology0.57231986
149MP0001915_intracranial_hemorrhage0.54877560
150MP0005275_abnormal_skin_tensile0.53276565
151MP0000534_abnormal_ureter_morphology0.52692087
152MP0001730_embryonic_growth_arrest0.51660304
153MP0001661_extended_life_span0.48049420
154MP0000367_abnormal_coat/_hair0.47521130
155MP0003950_abnormal_plasma_membrane0.47417253
156MP0001958_emphysema0.47387254
157MP0003279_aneurysm0.47290879
158MP0005501_abnormal_skin_physiology0.46128671
159MP0005503_abnormal_tendon_morphology0.45376520
160MP0008932_abnormal_embryonic_tissue0.45102128
161MP0010094_abnormal_chromosome_stability0.44685180
162MP0005193_abnormal_anterior_eye0.43798652
163MP0003959_abnormal_lean_body0.43500501
164MP0000733_abnormal_muscle_development0.43281118
165MP0003077_abnormal_cell_cycle0.43237948
166MP0000566_synostosis0.42635911
167MP0002080_prenatal_lethality0.41621791
168MP0003115_abnormal_respiratory_system0.41390791
169MP0005451_abnormal_body_composition0.40838373
170MP0000767_abnormal_smooth_muscle0.39787209

Predicted human phenotypes

RankGene SetZ-score
1White forelock (HP:0002211)5.56127126
2Pustule (HP:0200039)5.25847524
3Colitis (HP:0002583)5.25719089
4Patchy hypopigmentation of hair (HP:0011365)4.91727785
5Blue irides (HP:0000635)4.91122964
6Aplasia/Hypoplasia of the fovea (HP:0008060)4.90294645
7Hypoplasia of the fovea (HP:0007750)4.90294645
8Hypopigmentation of the fundus (HP:0007894)4.63181866
9Aplasia/Hypoplasia of the macula (HP:0008059)4.63174606
10Retinal atrophy (HP:0001105)4.39383589
11Aplasia/Hypoplasia affecting the retina (HP:0008061)4.28325021
12Inflammation of the large intestine (HP:0002037)4.07454575
13Systemic lupus erythematosus (HP:0002725)4.01581396
14Glomerulonephritis (HP:0000099)3.89976346
15Protrusio acetabuli (HP:0003179)3.89831978
16Gastrointestinal inflammation (HP:0004386)3.85855821
17Abnormality of the fovea (HP:0000493)3.77368033
18Alopecia of scalp (HP:0002293)3.76060280
19Complement deficiency (HP:0004431)3.67921628
20Dysostosis multiplex (HP:0000943)3.55399974
21Diplopia (HP:0000651)3.52279076
22Abnormality of binocular vision (HP:0011514)3.52279076
23Thyroid-stimulating hormone excess (HP:0002925)3.51834297
24Hemiplegia (HP:0002301)3.48455206
25Heterochromia iridis (HP:0001100)3.45031180
26Vertebral compression fractures (HP:0002953)3.38989610
27Obstructive sleep apnea (HP:0002870)3.37576916
28Cerebral aneurysm (HP:0004944)3.11316146
29Hypoplasia of the iris (HP:0007676)3.10551468
30Generalized hypopigmentation of hair (HP:0011358)2.99647003
31Broad metatarsal (HP:0001783)2.95208636
32Ocular albinism (HP:0001107)2.92785314
33Arterial tortuosity (HP:0005116)2.88783211
34Mutism (HP:0002300)2.88249434
35Disproportionate tall stature (HP:0001519)2.87022710
36Premature rupture of membranes (HP:0001788)2.80866143
37Short chin (HP:0000331)2.76071527
38Myokymia (HP:0002411)2.72726734
39Flat acetabular roof (HP:0003180)2.71779175
40Arnold-Chiari malformation (HP:0002308)2.68827083
41Vascular tortuosity (HP:0004948)2.68770161
42Abnormality of complement system (HP:0005339)2.63420542
43Hyperacusis (HP:0010780)2.63270727
44Annular pancreas (HP:0001734)2.60816716
45Polygenic inheritance (HP:0010982)2.57766357
46Freckling (HP:0001480)2.55608528
47Cerebral inclusion bodies (HP:0100314)2.54431903
48Abnormality of glycolipid metabolism (HP:0010969)2.51930843
49Abnormality of liposaccharide metabolism (HP:0010968)2.51930843
50Abnormality of glycosphingolipid metabolism (HP:0004343)2.51930843
51Mucopolysacchariduria (HP:0008155)2.46788854
52Urinary glycosaminoglycan excretion (HP:0003541)2.46788854
53Iris hypopigmentation (HP:0007730)2.46779657
54Aortic aneurysm (HP:0004942)2.45833259
55Nephritis (HP:0000123)2.45756617
56Hypoalphalipoproteinemia (HP:0003233)2.44063208
57Focal motor seizures (HP:0011153)2.42364041
58Amyloidosis (HP:0011034)2.39959200
59Lower limb asymmetry (HP:0100559)2.39727028
60Abnormality of mucopolysaccharide metabolism (HP:0011020)2.37250575
61Abnormality of polysaccharide metabolism (HP:0011012)2.37250575
62Abnormality of glycosaminoglycan metabolism (HP:0004371)2.37250575
63Panhypogammaglobulinemia (HP:0003139)2.36865118
64Generalized hypopigmentation (HP:0007513)2.36782757
65Peripheral hypomyelination (HP:0007182)2.30688881
66Increased cerebral lipofuscin (HP:0011813)2.30140654
67Deep venous thrombosis (HP:0002625)2.27018017
68Supranuclear gaze palsy (HP:0000605)2.23251959
69Cheilitis (HP:0100825)2.23009215
70Loss of speech (HP:0002371)2.21456539
71Mesangial abnormality (HP:0001966)2.21281370
72Ulnar bowing (HP:0003031)2.20541285
73Premature graying of hair (HP:0002216)2.20009566
74Striae distensae (HP:0001065)2.17236688
75Partial duplication of thumb phalanx (HP:0009944)2.16871036
76Urethral obstruction (HP:0000796)2.16101207
77Milia (HP:0001056)2.15050848
78Viral hepatitis (HP:0006562)2.14078396
79Asymmetry of the thorax (HP:0001555)2.13616056
80Abnormal eating behavior (HP:0100738)2.11221014
81Shallow orbits (HP:0000586)2.09674309
82Action tremor (HP:0002345)2.09311361
83Alacrima (HP:0000522)2.09218054
84Abnormal auditory evoked potentials (HP:0006958)2.07624689
85Epileptic encephalopathy (HP:0200134)2.05692807
86Germ cell neoplasia (HP:0100728)2.01677929
87Insomnia (HP:0100785)2.01470176
88Spastic paraparesis (HP:0002313)2.00101957
89Onycholysis (HP:0001806)2.00024141
90Chronic diarrhea (HP:0002028)1.99154252
91Paraparesis (HP:0002385)1.98351699
92Reduced subcutaneous adipose tissue (HP:0003758)1.97884227
93Thoracic kyphosis (HP:0002942)1.97839876
94Tetraplegia (HP:0002445)1.97537597
95Hemiparesis (HP:0001269)1.97528702
96Facial diplegia (HP:0001349)1.97391000
97J-shaped sella turcica (HP:0002680)1.96212639
98Increased neuronal autofluorescent lipopigment (HP:0002074)1.96156815
99Aplasia involving bones of the extremities (HP:0009825)1.96125354
100Aplasia involving bones of the upper limbs (HP:0009823)1.96125354
101Aplasia of the phalanges of the hand (HP:0009802)1.96125354
102Partial duplication of the phalanx of hand (HP:0009999)1.95392348
103Deformed sella turcica (HP:0002681)1.94992918
104Neurofibrillary tangles (HP:0002185)1.93375816
105Postural instability (HP:0002172)1.93186048
106Distal upper limb amyotrophy (HP:0007149)1.92141518
107Upper limb amyotrophy (HP:0009129)1.92141518
108Back pain (HP:0003418)1.91224771
109Abnormal delayed hypersensitivity skin test (HP:0002963)1.91214840
110Centrally nucleated skeletal muscle fibers (HP:0003687)1.91048200
111Gastrointestinal stroma tumor (HP:0100723)1.89989573
112Cerebral hypomyelination (HP:0006808)1.88848767
113Acanthosis nigricans (HP:0000956)1.87520815
114Bilateral sensorineural hearing impairment (HP:0008619)1.87105480
115Abnormality of the salivary glands (HP:0010286)1.86634024
116Atrophic scars (HP:0001075)1.84871170
117Hyperpituitarism (HP:0010514)1.84553768
118Increased density of long bones (HP:0006392)1.82254796
119Genu recurvatum (HP:0002816)1.80822906
120Abnormality of small intestinal villus morphology (HP:0011472)1.80734709
121Villous atrophy (HP:0011473)1.80734709
122Lower limb amyotrophy (HP:0007210)1.80589297
123Wormian bones (HP:0002645)1.80506094
124Hematochezia (HP:0002573)1.80135540
125Megalencephaly (HP:0001355)1.79899752
126Hyperlipoproteinemia (HP:0010980)1.79752673
127Distal lower limb amyotrophy (HP:0008944)1.79733448
128Abnormality of the Achilles tendon (HP:0005109)1.78466864
129Mitral valve prolapse (HP:0001634)1.78076395
130Spinal cord compression (HP:0002176)1.76259629
131Termporal pattern (HP:0011008)1.76165957
132Insidious onset (HP:0003587)1.76165957
133Osteolytic defects of the hand bones (HP:0009699)1.76087213
134Osteolytic defects of the phalanges of the hand (HP:0009771)1.76087213
135Neuronal loss in central nervous system (HP:0002529)1.75511075
136Oligomenorrhea (HP:0000876)1.74505853
137Abnormality of nail color (HP:0100643)1.73792343
138Aortic dissection (HP:0002647)1.73465686
139Spinal rigidity (HP:0003306)1.72176631
140Visual hallucinations (HP:0002367)1.70410037
141Macroorchidism (HP:0000053)1.70132710
142Abnormality of T cell physiology (HP:0011840)1.69375060
143Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.69149824
144Progressive visual loss (HP:0000529)1.68845675
145Ankle contracture (HP:0006466)1.68115189
146Spondylolisthesis (HP:0003302)1.68087622
147Distal lower limb muscle weakness (HP:0009053)1.68005194
148Status epilepticus (HP:0002133)1.67987249
149Clumsiness (HP:0002312)1.67845144
150Urinary bladder sphincter dysfunction (HP:0002839)1.67580153
151Multifactorial inheritance (HP:0001426)1.65585384
152Achilles tendon contracture (HP:0001771)1.65514199
153Distal sensory impairment (HP:0002936)1.65088083
154Spinal canal stenosis (HP:0003416)1.64410497
155Abnormality of the 1st metacarpal (HP:0010009)1.64227415
156Hand muscle atrophy (HP:0009130)1.63857334
157Cutaneous melanoma (HP:0012056)1.63317548
158Nuclear cataract (HP:0100018)1.61971689
159Albinism (HP:0001022)1.57174683
160Nasolacrimal duct obstruction (HP:0000579)1.57077699
161Pointed chin (HP:0000307)1.56696730
162Hypercortisolism (HP:0001578)1.55097592
163Dysmetric saccades (HP:0000641)1.54076208
164Truncal ataxia (HP:0002078)1.53454437
165Abnormality of the thoracic spine (HP:0100711)1.53367573
166Neonatal short-limb short stature (HP:0008921)1.53058631
167Hemorrhage of the eye (HP:0011885)1.52988725
168Neonatal death (HP:0003811)1.49975340
169Decreased lacrimation (HP:0000633)1.49934149
170Hyperparathyroidism (HP:0000843)1.48983130
171Broad face (HP:0000283)1.47277617
172Growth hormone excess (HP:0000845)1.47006448
173Elbow flexion contracture (HP:0002987)1.45191192
174Nonimmune hydrops fetalis (HP:0001790)1.43653219
175Bladder diverticulum (HP:0000015)1.42182747
176Blue sclerae (HP:0000592)1.41230190
177Hyperextensible skin (HP:0000974)1.41125308
178Advanced eruption of teeth (HP:0006288)1.39692703
179Increased nuchal translucency (HP:0010880)1.39474481
180Apathy (HP:0000741)1.39129262
181Impaired pain sensation (HP:0007328)1.37799998
182Abnormality of pain sensation (HP:0010832)1.37799998

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.53449754
2EEF2K4.17414424
3MAP3K64.13892358
4PRPF4B3.67180477
5PIK3CA3.64114113
6TGFBR23.63899431
7MST1R3.07542640
8ICK3.04345206
9CAMK1D2.81029038
10SMG12.67451940
11CDK122.47523358
12MAPKAPK52.41626337
13KSR22.39516821
14MAPKAPK32.35048527
15MAP2K32.14737393
16CAMK1G1.98868001
17SCYL21.98684184
18MAP2K41.83329045
19LATS21.79810058
20PDGFRA1.77811371
21MAP3K21.76619751
22MAPK151.61858581
23TRIB31.52368979
24MAP3K91.50078071
25FES1.48327117
26WEE11.43132768
27PTK21.42112320
28MAPK121.36080490
29ARAF1.32740493
30MAP2K61.31950114
31RET1.28408103
32EPHA41.26642569
33FGFR41.26364617
34RIPK11.25670573
35MTOR1.24063846
36NME21.23828263
37CAMKK21.21117412
38MINK11.20301161
39PKN21.19929315
40LMTK21.16896746
41PDPK11.16674065
42MAP3K131.12666636
43CAMKK11.09850286
44MATK1.03087650
45IRAK31.02524052
46MAP2K11.01797419
47TIE10.99035309
48GRK70.98967154
49ERN10.97771037
50PAK60.96355049
51CSF1R0.94530038
52TESK10.93416083
53CAMK10.92336936
54MAP3K40.91852790
55CAMK40.91602945
56PRKD30.90775685
57AKT20.90017725
58ZAP700.89559073
59CDK70.88582702
60FER0.88356684
61TAOK20.88010079
62PAK40.86486686
63MAPK130.85845440
64IRAK20.85558669
65BRAF0.85472635
66BRSK10.84979275
67JAK20.82957347
68NTRK30.81437750
69MAP3K70.80960356
70TBK10.80631331
71SGK30.79556079
72TYRO30.79371321
73NTRK20.78340731
74PRKAA20.78160973
75MAPK70.76594023
76MAP3K10.76172430
77RAF10.76154808
78PDK20.75630307
79DAPK10.75334853
80EPHA20.75026721
81MET0.74265444
82TSSK60.74208474
83KDR0.74113176
84NEK60.73347645
85PHKG20.72452250
86PHKG10.72452250
87MAP2K20.72172916
88DMPK0.69965090
89PRKD20.69281703
90PRKG20.68547889
91TNK20.67740237
92FGFR30.67212155
93GRK50.66523054
94JAK10.64654018
95STK100.63887161
96CDK60.63747969
97DAPK20.63474920
98PRKCH0.63166437
99IGF1R0.63080778
100RPS6KB20.62502413
101MAP3K30.62221005
102NEK90.60508022
103MAPK100.57787302
104LRRK20.56069479
105CAMK2D0.55968440
106UHMK10.55207026
107CDC70.54619260
108TTK0.53060863
109SGK2230.52878358
110SGK4940.52878358
111MAP3K100.51463095
112MELK0.51407744
113RIPK40.50295018
114TRPM70.50282511
115CDK80.50201123
116CDK40.49959752
117PRKD10.49675599
118STK110.49562740
119BCKDK0.49497439
120PTK60.48319474
121NLK0.48165919
122MARK30.48151863
123TTN0.47472580
124SGK20.47265321
125MOS0.46660102
126CDK90.46121198
127EIF2AK10.45930580
128ITK0.45458594
129ABL20.45267056
130DAPK30.44868484
131ALK0.44744815
132SIK10.44529459
133PIM20.43957316
134* CDK150.43793547
135PDK10.40917580
136MAP3K80.40739413
137RPS6KA20.40487738
138CSK0.40403205
139MAP3K110.39903129
140* CDK11A0.39870287
141STK380.39075040
142CDK50.37736381
143KIT0.36086386
144PRKAA10.35749010
145MARK20.34001230
146STK240.33233949
147FYN0.32401172
148LYN0.31589565
149NTRK10.31480925
150MAP2K70.31167977
151NUAK10.28281982
152PAK20.27880720
153GSK3A0.27715467
154IKBKB0.27305406
155DDR20.25695455
156MUSK0.25261246
157BTK0.24181944
158MAPK110.23757220

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.02719767
2Vitamin B6 metabolism_Homo sapiens_hsa007502.69317753
3Tyrosine metabolism_Homo sapiens_hsa003502.56595340
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.48759049
5Salivary secretion_Homo sapiens_hsa049702.13742167
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.99821424
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.74400869
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.72740615
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.68450372
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.65781090
11Bile secretion_Homo sapiens_hsa049761.65110712
12Cyanoamino acid metabolism_Homo sapiens_hsa004601.60072160
13Fatty acid biosynthesis_Homo sapiens_hsa000611.58159415
14Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.57967277
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.47212924
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.46427177
17Sulfur metabolism_Homo sapiens_hsa009201.44326214
18Gastric acid secretion_Homo sapiens_hsa049711.42439674
19Biosynthesis of amino acids_Homo sapiens_hsa012301.42345167
20Central carbon metabolism in cancer_Homo sapiens_hsa052301.40081789
21Osteoclast differentiation_Homo sapiens_hsa043801.37769801
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34210505
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33088135
24Non-small cell lung cancer_Homo sapiens_hsa052231.32342017
25Long-term potentiation_Homo sapiens_hsa047201.31474582
26Sulfur relay system_Homo sapiens_hsa041221.31417948
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30028988
28Renin secretion_Homo sapiens_hsa049241.24375353
29Phenylalanine metabolism_Homo sapiens_hsa003601.24187740
30Circadian rhythm_Homo sapiens_hsa047101.23042184
31Lysine degradation_Homo sapiens_hsa003101.21906546
32Small cell lung cancer_Homo sapiens_hsa052221.20992595
33AMPK signaling pathway_Homo sapiens_hsa041521.20425259
34Olfactory transduction_Homo sapiens_hsa047401.18429837
35GnRH signaling pathway_Homo sapiens_hsa049121.18149735
36Insulin signaling pathway_Homo sapiens_hsa049101.17770592
37Circadian entrainment_Homo sapiens_hsa047131.17100998
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16568332
39Bladder cancer_Homo sapiens_hsa052191.16007616
40Vibrio cholerae infection_Homo sapiens_hsa051101.15725505
41Mineral absorption_Homo sapiens_hsa049781.14687586
42GABAergic synapse_Homo sapiens_hsa047271.13566984
43Pancreatic secretion_Homo sapiens_hsa049721.13023455
44ABC transporters_Homo sapiens_hsa020101.11858432
45PPAR signaling pathway_Homo sapiens_hsa033201.11094654
46Fatty acid metabolism_Homo sapiens_hsa012121.10780176
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10248950
48mTOR signaling pathway_Homo sapiens_hsa041501.07900642
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.06248897
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05206320
51Glutamatergic synapse_Homo sapiens_hsa047241.05163192
52N-Glycan biosynthesis_Homo sapiens_hsa005101.04983267
53ErbB signaling pathway_Homo sapiens_hsa040121.04782631
54Gap junction_Homo sapiens_hsa045401.02917284
55Prostate cancer_Homo sapiens_hsa052151.02809333
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01679121
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00857274
58Morphine addiction_Homo sapiens_hsa050320.99863460
59Nicotine addiction_Homo sapiens_hsa050330.99710327
60Focal adhesion_Homo sapiens_hsa045100.99330590
61Dorso-ventral axis formation_Homo sapiens_hsa043200.98815285
62ECM-receptor interaction_Homo sapiens_hsa045120.98196392
63Other glycan degradation_Homo sapiens_hsa005110.97992370
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97411566
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96929493
66Staphylococcus aureus infection_Homo sapiens_hsa051500.96717242
67Pentose phosphate pathway_Homo sapiens_hsa000300.96596986
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96029060
69Pancreatic cancer_Homo sapiens_hsa052120.95095305
70Estrogen signaling pathway_Homo sapiens_hsa049150.93718075
71Adherens junction_Homo sapiens_hsa045200.93579586
72Pyruvate metabolism_Homo sapiens_hsa006200.92050935
73Glycerolipid metabolism_Homo sapiens_hsa005610.91380403
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90285511
75Proteoglycans in cancer_Homo sapiens_hsa052050.90099076
76cAMP signaling pathway_Homo sapiens_hsa040240.89548537
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88314993
78Insulin secretion_Homo sapiens_hsa049110.87895276
79Oxytocin signaling pathway_Homo sapiens_hsa049210.87526430
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86215478
81Carbon metabolism_Homo sapiens_hsa012000.85999130
82Platelet activation_Homo sapiens_hsa046110.84659671
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.84582019
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84512465
85Renal cell carcinoma_Homo sapiens_hsa052110.84440597
86Thyroid cancer_Homo sapiens_hsa052160.84146678
87Calcium signaling pathway_Homo sapiens_hsa040200.84013097
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83131505
89Long-term depression_Homo sapiens_hsa047300.81747566
90Fatty acid degradation_Homo sapiens_hsa000710.79195827
91Melanoma_Homo sapiens_hsa052180.79009074
92B cell receptor signaling pathway_Homo sapiens_hsa046620.78530618
93Cocaine addiction_Homo sapiens_hsa050300.77241995
94Butanoate metabolism_Homo sapiens_hsa006500.77062962
95VEGF signaling pathway_Homo sapiens_hsa043700.77045961
96Cholinergic synapse_Homo sapiens_hsa047250.77007909
97African trypanosomiasis_Homo sapiens_hsa051430.76747033
98Arginine and proline metabolism_Homo sapiens_hsa003300.76188906
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74981019
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74391376
101Leishmaniasis_Homo sapiens_hsa051400.74262671
102Fatty acid elongation_Homo sapiens_hsa000620.73748283
103MicroRNAs in cancer_Homo sapiens_hsa052060.73721338
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72231642
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.71693106
106Inositol phosphate metabolism_Homo sapiens_hsa005620.70683074
107Arginine biosynthesis_Homo sapiens_hsa002200.70301109
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.68461919
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68373792
110Salmonella infection_Homo sapiens_hsa051320.68314874
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66946350
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66867756
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66804430
114Glucagon signaling pathway_Homo sapiens_hsa049220.66266812
115Prion diseases_Homo sapiens_hsa050200.64882506
116Lysosome_Homo sapiens_hsa041420.64490332
117Propanoate metabolism_Homo sapiens_hsa006400.63726894
118Acute myeloid leukemia_Homo sapiens_hsa052210.63577194
119Oocyte meiosis_Homo sapiens_hsa041140.61625423
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.60347736
121Dopaminergic synapse_Homo sapiens_hsa047280.59267093
122Hippo signaling pathway_Homo sapiens_hsa043900.59055430
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58669204
124Insulin resistance_Homo sapiens_hsa049310.58496354
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58387828
126Type II diabetes mellitus_Homo sapiens_hsa049300.57328652
127Pertussis_Homo sapiens_hsa051330.57303676
128Prolactin signaling pathway_Homo sapiens_hsa049170.56585819
129Melanogenesis_Homo sapiens_hsa049160.56564856
130Toxoplasmosis_Homo sapiens_hsa051450.56172675
131Amphetamine addiction_Homo sapiens_hsa050310.55926970
132Thyroid hormone synthesis_Homo sapiens_hsa049180.55804238
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55787208
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55116641
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55098621
136Choline metabolism in cancer_Homo sapiens_hsa052310.54977064
137Rap1 signaling pathway_Homo sapiens_hsa040150.54270067
138One carbon pool by folate_Homo sapiens_hsa006700.52384054
139Cell cycle_Homo sapiens_hsa041100.51738815
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.51704591
141beta-Alanine metabolism_Homo sapiens_hsa004100.51231247
142Fructose and mannose metabolism_Homo sapiens_hsa000510.50775962
143Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49762893
144Protein digestion and absorption_Homo sapiens_hsa049740.49391242
145Colorectal cancer_Homo sapiens_hsa052100.48874736
146Glioma_Homo sapiens_hsa052140.48431952
147Ovarian steroidogenesis_Homo sapiens_hsa049130.48355373
148Notch signaling pathway_Homo sapiens_hsa043300.48299823
149Chronic myeloid leukemia_Homo sapiens_hsa052200.47712795
150Sphingolipid metabolism_Homo sapiens_hsa006000.47423230
151HIF-1 signaling pathway_Homo sapiens_hsa040660.47075221
152Endometrial cancer_Homo sapiens_hsa052130.46187229
153Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45073868
154Synaptic vesicle cycle_Homo sapiens_hsa047210.44992371
155Endocytosis_Homo sapiens_hsa041440.44447301
156Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44425110
157Hepatitis C_Homo sapiens_hsa051600.41576660

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