CABP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to a subfamily of calcium binding proteins that share similarity to calmodulin. Like calmodulin, these family members can likely stimulate calmodulin-dependent kinase II and the protein phosphatase calcineurin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cobalamin metabolic process (GO:0009235)7.85220755
2transcytosis (GO:0045056)7.50940374
3sterol catabolic process (GO:0016127)7.40246086
4cholesterol catabolic process (GO:0006707)7.40246086
5peptidyl-proline hydroxylation (GO:0019511)7.17151800
6regulation of phospholipase A2 activity (GO:0032429)7.03905288
7cysteine metabolic process (GO:0006534)6.89450254
8intestinal absorption (GO:0050892)6.88963966
9negative regulation of digestive system process (GO:0060457)6.63071222
10glycolipid catabolic process (GO:0019377)6.31494834
11proline biosynthetic process (GO:0006561)5.99105383
12branched-chain amino acid catabolic process (GO:0009083)5.88411533
13membrane lipid catabolic process (GO:0046466)5.86968715
14valine metabolic process (GO:0006573)5.55153416
15protein hydroxylation (GO:0018126)5.38968265
16cellular modified amino acid catabolic process (GO:0042219)5.32633481
17serine family amino acid biosynthetic process (GO:0009070)5.20798255
18branched-chain amino acid metabolic process (GO:0009081)5.12169314
19ceramide catabolic process (GO:0046514)5.08883669
20positive regulation of heat generation (GO:0031652)4.96699261
21COPI coating of Golgi vesicle (GO:0048205)4.93641324
22Golgi transport vesicle coating (GO:0048200)4.93641324
23mitochondrial calcium ion transport (GO:0006851)4.87162833
24zinc ion transport (GO:0006829)4.83705890
25regulation of fever generation (GO:0031620)4.81129302
26GDP-mannose metabolic process (GO:0019673)4.80777903
27aspartate family amino acid catabolic process (GO:0009068)4.78804532
28protein maturation by protein folding (GO:0022417)4.69320206
29homocysteine metabolic process (GO:0050667)4.66870232
30leukotriene biosynthetic process (GO:0019370)4.61715172
31activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.43379815
32response to endoplasmic reticulum stress (GO:0034976)4.33927704
33L-serine metabolic process (GO:0006563)4.27453201
34creatine metabolic process (GO:0006600)4.24376498
354-hydroxyproline metabolic process (GO:0019471)4.24114146
36positive regulation of nuclease activity (GO:0032075)4.23063456
37signal peptide processing (GO:0006465)4.11212050
38proline metabolic process (GO:0006560)4.10249387
39endoplasmic reticulum unfolded protein response (GO:0030968)4.07664572
40maintenance of protein localization in organelle (GO:0072595)4.07026655
41erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.02665421
42L-phenylalanine catabolic process (GO:0006559)4.02665421
43serine family amino acid metabolic process (GO:0009069)4.02309408
44intestinal epithelial cell development (GO:0060576)4.00412295
45neutrophil mediated immunity (GO:0002446)3.98404395
46response to pheromone (GO:0019236)3.96803358
47cellular response to unfolded protein (GO:0034620)3.96421538
48coenzyme catabolic process (GO:0009109)3.93154282
49glutamine metabolic process (GO:0006541)3.88994678
50regulation of nuclease activity (GO:0032069)3.83188516
51erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.81364434
52L-phenylalanine metabolic process (GO:0006558)3.81364434
53cellular response to topologically incorrect protein (GO:0035967)3.81220120
54mitochondrion distribution (GO:0048311)3.80396586
55regulation of heat generation (GO:0031650)3.78501879
56steroid catabolic process (GO:0006706)3.74472162
57ER-nucleus signaling pathway (GO:0006984)3.74185397
58sulfur amino acid biosynthetic process (GO:0000097)3.56362385
59ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.54558578
60retinoic acid receptor signaling pathway (GO:0048384)3.53074296
61negative regulation of epidermal cell differentiation (GO:0045605)3.41873730
62glycine metabolic process (GO:0006544)3.40897906
63arachidonic acid secretion (GO:0050482)3.36345814
64icosanoid secretion (GO:0032309)3.36345814
65antibacterial humoral response (GO:0019731)3.35398988
66cell redox homeostasis (GO:0045454)3.35016577
67regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.34187971
68retina layer formation (GO:0010842)3.25557754
69response to unfolded protein (GO:0006986)3.25035606
70negative regulation of cell fate commitment (GO:0010454)3.23711695
71alpha-amino acid biosynthetic process (GO:1901607)3.22625074
72COPII vesicle coating (GO:0048208)3.22145351
73sphingolipid catabolic process (GO:0030149)3.21500692
74glycine transport (GO:0015816)3.17006019
75response to topologically incorrect protein (GO:0035966)3.15769520
76protein N-linked glycosylation via asparagine (GO:0018279)3.14921094
77ER overload response (GO:0006983)3.12009217
78peptidyl-asparagine modification (GO:0018196)3.11761253
79antimicrobial humoral response (GO:0019730)3.08417784
80pancreas development (GO:0031016)3.06206238
81endocrine pancreas development (GO:0031018)3.04575627
82myeloid leukocyte mediated immunity (GO:0002444)3.02635096
83aspartate family amino acid metabolic process (GO:0009066)2.99435987
84biotin metabolic process (GO:0006768)2.99181045
85polarized epithelial cell differentiation (GO:0030859)2.98815458
86activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.95610020
87L-alpha-amino acid transmembrane transport (GO:1902475)2.94898988
88regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)2.92711957
89cellular amino acid catabolic process (GO:0009063)2.91027407
90cellular protein catabolic process (GO:0044257)2.90349626
91sulfur amino acid catabolic process (GO:0000098)2.88458586
92protein N-linked glycosylation (GO:0006487)2.87725968
93peptidyl-proline modification (GO:0018208)2.84688092
94regulation of oxidative stress-induced cell death (GO:1903201)2.82195545
95monoamine transport (GO:0015844)2.81695851
96exocrine pancreas development (GO:0031017)17.1547975
97intestinal cholesterol absorption (GO:0030299)16.2636670
98digestion (GO:0007586)13.4141651
99protein retention in ER lumen (GO:0006621)12.1134000
100maintenance of protein localization in endoplasmic reticulum (GO:0035437)11.2930414

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat8.40856176
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.19575395
3ERG_21242973_ChIP-ChIP_JURKAT_Human3.71029237
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.11390086
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.09741758
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.83101030
7ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.82468563
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.69262953
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.59113292
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.54643444
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.43943788
12CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.38552107
13PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse2.33225944
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.29126444
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.29126444
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.29126444
17GATA4_25053715_ChIP-Seq_YYC3_Human2.12972948
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.02970918
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97966090
20CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.97379381
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.91494164
22LXR_22158963_ChIP-Seq_LIVER_Mouse1.86647630
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.80419608
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.78820016
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76770561
26SOX2_27498859_Chip-Seq_STOMACH_Mouse1.70317160
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.69906724
28GATA6_25053715_ChIP-Seq_YYC3_Human1.66205742
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58358017
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55060723
31SA1_27219007_Chip-Seq_ERYTHROID_Human1.52275241
32PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.42265261
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40919572
34SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.34457268
35EGR1_19032775_ChIP-ChIP_M12_Human1.33576641
36P68_20966046_ChIP-Seq_HELA_Human1.33157062
37ERA_21632823_ChIP-Seq_H3396_Human1.29063832
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28917703
39HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25662568
40ESET_19884257_ChIP-Seq_ESCs_Mouse1.25452036
41LXR_22292898_ChIP-Seq_THP-1_Human1.25068376
42ERG_20517297_ChIP-Seq_VCAP_Human1.24418674
43OCT4_20526341_ChIP-Seq_ESCs_Human1.21673971
44IRF1_19129219_ChIP-ChIP_H3396_Human1.19703528
45CTCF_27219007_Chip-Seq_Bcells_Human1.19676820
46BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.17962319
47SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17715752
48CREB1_26743006_Chip-Seq_LNCaP_Human1.15077447
49SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15010341
50ETS1_21867929_ChIP-Seq_TH2_Mouse1.13833035
51P53_21459846_ChIP-Seq_SAOS-2_Human1.13365185
52CHD1_26751641_Chip-Seq_LNCaP_Human1.13192894
53P63_26484246_Chip-Seq_KERATINOCYTES_Human1.12642017
54ELK4_26923725_Chip-Seq_MESODERM_Mouse1.07855918
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06189012
56* TAF2_19829295_ChIP-Seq_ESCs_Human1.06053637
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05589676
58CTCF_20526341_ChIP-Seq_ESCs_Human1.05268781
59SA1_27219007_Chip-Seq_Bcells_Human1.05181553
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03276236
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02757637
62BCOR_27268052_Chip-Seq_Bcells_Human0.99553673
63FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.98255503
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96239275
65SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.96174891
66CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95840329
67TAF15_26573619_Chip-Seq_HEK293_Human0.95439014
68* TP63_22573176_ChIP-Seq_HFKS_Human0.94559335
69CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93782816
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93700546
71TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91143220
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90088396
73SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89339569
74HTT_18923047_ChIP-ChIP_STHdh_Human0.89255308
75FOXP1_21924763_ChIP-Seq_HESCs_Human0.88846633
76SMAD4_21741376_ChIP-Seq_ESCs_Human0.87446551
77* FOXH1_21741376_ChIP-Seq_ESCs_Human0.87367610
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87063618
79RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.86963285
80ATF3_27146783_Chip-Seq_COLON_Human0.85106785
81CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85035558
82SOX2_21211035_ChIP-Seq_LN229_Human0.84836991
83SOX2_20726797_ChIP-Seq_SW620_Human0.84381913
84CTCF_18555785_ChIP-Seq_MESCs_Mouse0.84024950
85CEBPB_22108803_ChIP-Seq_LS180_Human0.83695593
86ETS1_20019798_ChIP-Seq_JURKAT_Human0.83628399
87KLF4_19829295_ChIP-Seq_ESCs_Human0.83011982
88GATA1_26923725_Chip-Seq_HPCs_Mouse0.82510858
89ZNF274_21170338_ChIP-Seq_K562_Hela0.82270189
90HNFA_21074721_ChIP-Seq_CACO-2_Human0.81610122
91AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81419742
92JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.80010968
93STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.79641778
94PU.1_20513432_ChIP-Seq_Bcells_Mouse0.77948760
95FOXA2_19822575_ChIP-Seq_HepG2_Human0.77337405
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.77107131
97SMC4_20622854_ChIP-Seq_HELA_Human0.77012309
98FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.76944354
99EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.76862336
100CLOCK_20551151_ChIP-Seq_293T_Human0.76280961

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract9.45630545
2MP0001666_abnormal_nutrient_absorption9.26091903
3MP0005220_abnormal_exocrine_pancreas7.00152943
4MP0005365_abnormal_bile_salt6.64954725
5MP0003868_abnormal_feces_composition4.93729911
6MP0005084_abnormal_gallbladder_morpholo4.61264076
7MP0005085_abnormal_gallbladder_physiolo3.46942864
8MP0001664_abnormal_digestion2.67616228
9MP0002693_abnormal_pancreas_physiology2.59400971
10MP0003959_abnormal_lean_body2.52582321
11MP0004233_abnormal_muscle_weight2.09474170
12MP0002277_abnormal_respiratory_mucosa2.08046545
13MP0005451_abnormal_body_composition1.91161428
14MP0003705_abnormal_hypodermis_morpholog1.84237345
15MP0002139_abnormal_hepatobiliary_system1.64225950
16MP0001944_abnormal_pancreas_morphology1.64190391
17MP0003638_abnormal_response/metabolism_1.62122090
18MP0005448_abnormal_energy_balance1.61239821
19MP0005332_abnormal_amino_acid1.48688928
20MP0002118_abnormal_lipid_homeostasis1.37026232
21MP0004264_abnormal_extraembryonic_tissu1.36648015
22MP0008789_abnormal_olfactory_epithelium1.34020673
23MP0001873_stomach_inflammation1.20755086
24MP0005165_increased_susceptibility_to1.18228098
25MP0010234_abnormal_vibrissa_follicle1.08298095
26MP0005499_abnormal_olfactory_system1.07535085
27MP0005394_taste/olfaction_phenotype1.07535085
28MP0005535_abnormal_body_temperature0.94670667
29MP0000470_abnormal_stomach_morphology0.92845898
30MP0002078_abnormal_glucose_homeostasis0.92267626
31MP0005408_hypopigmentation0.90742460
32MP0008004_abnormal_stomach_pH0.87465958
33MP0005360_urolithiasis0.84445437
34MP0000490_abnormal_crypts_of0.82743977
35MP0001764_abnormal_homeostasis0.80927288
36MP0009643_abnormal_urine_homeostasis0.80230345
37MP0000003_abnormal_adipose_tissue0.79588058
38MP0001663_abnormal_digestive_system0.77914159
39MP0008438_abnormal_cutaneous_collagen0.72260834
40MP0002089_abnormal_postnatal_growth/wei0.71837047
41MP0003953_abnormal_hormone_level0.67684940
42MP0006036_abnormal_mitochondrial_physio0.67407252
43MP0003252_abnormal_bile_duct0.66373886
44MP0003806_abnormal_nucleotide_metabolis0.66133481
45MP0003186_abnormal_redox_activity0.65042495
46MP0009765_abnormal_xenobiotic_induced0.63714656
47MP0003879_abnormal_hair_cell0.63281518
48MP0005452_abnormal_adipose_tissue0.63201477
49MP0009384_cardiac_valve_regurgitation0.62658172
50MP0010329_abnormal_lipoprotein_level0.61822308
51MP0002090_abnormal_vision0.58324998
52MP0005058_abnormal_lysosome_morphology0.57729581
53MP0010386_abnormal_urinary_bladder0.57669568
54MP0000750_abnormal_muscle_regeneration0.56990715
55MP0008872_abnormal_physiological_respon0.56975296
56MP0005381_digestive/alimentary_phenotyp0.55689389
57MP0000613_abnormal_salivary_gland0.55317035
58MP0001731_abnormal_postnatal_growth0.51081597
59MP0002098_abnormal_vibrissa_morphology0.48231228
60MP0005551_abnormal_eye_electrophysiolog0.46031939
61MP0000598_abnormal_liver_morphology0.44306084
62MP0008961_abnormal_basal_metabolism0.43747307
63MP0001845_abnormal_inflammatory_respons0.42359505
64MP0002138_abnormal_hepatobiliary_system0.42129887
65MP0000955_abnormal_spinal_cord0.41913473
66MP0005319_abnormal_enzyme/_coenzyme0.41325524
67MP0000609_abnormal_liver_physiology0.40025689
68MP0000647_abnormal_sebaceous_gland0.39615829
69MP0002796_impaired_skin_barrier0.39112818
70MP0004142_abnormal_muscle_tone0.38492383
71MP0005386_behavior/neurological_phenoty0.37493407
72MP0004924_abnormal_behavior0.37493407
73MP0005334_abnormal_fat_pad0.36604578
74MP0000377_abnormal_hair_follicle0.34937329
75MP0001502_abnormal_circadian_rhythm0.34560079
76MP0000367_abnormal_coat/_hair0.33575661
77MP0002069_abnormal_eating/drinking_beha0.32190328
78MP0000778_abnormal_nervous_system0.32069486
79MP0000371_diluted_coat_color0.31271082
80MP0006054_spinal_hemorrhage0.31067768
81MP0002928_abnormal_bile_duct0.30812467
82MP0003956_abnormal_body_size0.30059054
83MP0003329_amyloid_beta_deposits0.29954057
84MP0005375_adipose_tissue_phenotype0.29834087
85MP0002184_abnormal_innervation0.29044476
86MP0002876_abnormal_thyroid_physiology0.28358496
87MP0002229_neurodegeneration0.28004420
88MP0003795_abnormal_bone_structure0.27945195
89MP0002638_abnormal_pupillary_reflex0.27917473
90MP0009642_abnormal_blood_homeostasis0.27507840
91MP0006035_abnormal_mitochondrial_morpho0.26618023
92MP0003656_abnormal_erythrocyte_physiolo0.26070064
93MP0001348_abnormal_lacrimal_gland0.24404050
94MP0005187_abnormal_penis_morphology0.24260124
95MP0005670_abnormal_white_adipose0.24033279
96MP0002060_abnormal_skin_morphology0.22576956
97MP0005636_abnormal_mineral_homeostasis0.22258193
98MP0009333_abnormal_splenocyte_physiolog0.21763757
99MP0005377_hearing/vestibular/ear_phenot0.21714335
100MP0003878_abnormal_ear_physiology0.21714335

Predicted human phenotypes

RankGene SetZ-score
1Steatorrhea (HP:0002570)8.50892829
2Short chin (HP:0000331)7.32049261
3Fat malabsorption (HP:0002630)6.87666008
4Decreased subcutaneous fat (HP:0001002)6.77525333
5Abnormality of subcutaneous fat tissue (HP:0001001)5.92536190
6Maternal diabetes (HP:0009800)5.86776083
7Type I diabetes mellitus (HP:0100651)5.79520418
8Gout (HP:0001997)5.50205735
9Abnormality of the intrinsic pathway (HP:0010989)4.74430016
10Exocrine pancreatic insufficiency (HP:0001738)4.58095940
11Hypoplasia of the pons (HP:0012110)4.39290964
12Abnormality of aromatic amino acid family metabolism (HP:0004338)4.35083783
13Joint stiffness (HP:0001387)4.32203809
14Abnormality of the pons (HP:0007361)4.18927185
15Optic nerve hypoplasia (HP:0000609)3.95889690
16Pancreatitis (HP:0001733)3.89942188
17Premature skin wrinkling (HP:0100678)3.87137353
18Ketosis (HP:0001946)3.85164235
19Hypoproteinemia (HP:0003075)3.80789167
20Cortical dysplasia (HP:0002539)3.69013351
21Tubulointerstitial nephritis (HP:0001970)3.57383871
22Aplasia/Hypoplasia of the optic nerve (HP:0008058)3.39384098
23Ketoacidosis (HP:0001993)3.32309410
24Hyperglycinemia (HP:0002154)3.29394988
25Prenatal maternal abnormality (HP:0002686)3.27517048
26Abnormality of sulfur amino acid metabolism (HP:0004339)3.21955482
27Long foot (HP:0001833)3.19221751
28Abnormal glycosylation (HP:0012345)3.05814557
29Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.05814557
30Abnormal protein N-linked glycosylation (HP:0012347)3.05814557
31Abnormal protein glycosylation (HP:0012346)3.05814557
32Carpal bone hypoplasia (HP:0001498)3.01677869
33Abnormality of glycine metabolism (HP:0010895)2.80632339
34Abnormality of serine family amino acid metabolism (HP:0010894)2.80632339
35Reduced antithrombin III activity (HP:0001976)2.78723342
36Abnormality of the common coagulation pathway (HP:0010990)2.78209726
37Fatigue (HP:0012378)2.74946773
38Hyperglycinuria (HP:0003108)2.72141156
39Tubulointerstitial fibrosis (HP:0005576)2.69664255
40Abnormality of methionine metabolism (HP:0010901)2.67966970
41Increased purine levels (HP:0004368)2.61702417
42Hyperuricemia (HP:0002149)2.61702417
43Abnormal pancreas size (HP:0012094)2.61217751
44Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.59364128
45Methylmalonic aciduria (HP:0012120)2.57416432
46Abnormality of endocrine pancreas physiology (HP:0012093)2.51579026
47Abnormality of the pancreatic islet cells (HP:0006476)2.51579026
48Pectus carinatum (HP:0000768)2.49060158
49Homocystinuria (HP:0002156)2.46677044
50Abnormality of homocysteine metabolism (HP:0010919)2.46677044
51Hypoglycemic coma (HP:0001325)2.45111961
52Progressive muscle weakness (HP:0003323)2.43075763
53Type II lissencephaly (HP:0007260)2.39503714
54Cerebellar dysplasia (HP:0007033)2.38809862
55Opisthotonus (HP:0002179)2.34280297
56Abnormality of aspartate family amino acid metabolism (HP:0010899)2.30726963
57Vacuolated lymphocytes (HP:0001922)2.23485265
58Acute encephalopathy (HP:0006846)2.19906649
59Type I transferrin isoform profile (HP:0003642)2.18517882
60EEG with generalized epileptiform discharges (HP:0011198)2.16895263
61Acute hepatic failure (HP:0006554)2.15698966
62Cortical visual impairment (HP:0100704)2.15680991
63Abnormal tarsal ossification (HP:0008369)2.15632573
64Cerebral edema (HP:0002181)2.12476872
65Redundant skin (HP:0001582)2.12208472
66Epileptiform EEG discharges (HP:0011182)2.06949939
67Myocardial infarction (HP:0001658)2.05128386
68Hypoglycemic seizures (HP:0002173)2.03766602
69Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.03178710
70Tubular atrophy (HP:0000092)2.02580077
71Dysostosis multiplex (HP:0000943)2.01575315
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.01047923
73Dicarboxylic aciduria (HP:0003215)2.01047923
74Large hands (HP:0001176)1.99793750
75Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.94898362
76Beaking of vertebral bodies (HP:0004568)1.94185856
77Hypsarrhythmia (HP:0002521)1.93953578
78Congenital glaucoma (HP:0001087)1.93293173
79Thoracic kyphosis (HP:0002942)1.90900545
80Hyperammonemia (HP:0001987)1.88883687
81Lethargy (HP:0001254)1.88852626
82Abnormality of serum amino acid levels (HP:0003112)1.88272410
83Hypoplasia of the odontoid process (HP:0003311)1.88110543
84Vascular calcification (HP:0004934)1.87266662
85Infantile muscular hypotonia (HP:0008947)1.87231830
86Progressive sensorineural hearing impairment (HP:0000408)1.81486380
87Small epiphyses (HP:0010585)1.80503567
88Athetosis (HP:0002305)1.75707780
89Renal salt wasting (HP:0000127)1.73356953
90Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.72940282
91Barrel-shaped chest (HP:0001552)1.71710010
92Prolonged QT interval (HP:0001657)1.70934332
93Brittle hair (HP:0002299)1.69971697
94Hypokinesia (HP:0002375)1.69613236
95Cardiovascular calcification (HP:0011915)1.68419129
96Coxa valga (HP:0002673)1.68158330
97Abnormality of the thoracic spine (HP:0100711)1.65664692
98Abnormality of the renal cortex (HP:0011035)1.63742232
99Late onset (HP:0003584)1.63729066
100Abnormality of purine metabolism (HP:0004352)1.63071811

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.71589507
2MAP2K24.19600755
3EIF2AK33.90410586
4NME12.99494156
5PKN22.80344078
6TRIB32.40755715
7INSRR2.17175103
8MAPKAPK32.05363293
9BCKDK10.6258835
10DYRK1A1.82422610
11MAP2K11.70820699
12PAK21.67166233
13SCYL21.63321659
14IRAK31.62510934
15ZAP701.61618215
16NME21.52423525
17FRK1.42475257
18RPS6KB21.30704985
19PIK3CG1.25585985
20PINK11.20891357
21WNK41.09599006
22EEF2K1.02037478
23PBK0.99320126
24PIK3CA0.95162081
25FLT30.94807334
26CAMKK10.91689842
27DAPK20.87098066
28RIPK10.83524982
29PTK60.80919934
30MAPK150.78898966
31STK160.77181495
32IRAK20.72614873
33MAPK120.70345992
34PDGFRB0.69337225
35TAOK30.66215645
36TAOK20.64697595
37MAP2K60.64154179
38IRAK10.63769432
39CAMKK20.63482603
40PRKCZ0.62781613
41STK390.60514271
42DYRK1B0.57064402
43MTOR0.54002709
44SIK10.53241399
45PAK60.51757786
46RPS6KB10.51558866
47PDK20.51065499
48MAP3K90.46473245
49STK38L0.43277808
50STK380.42890149
51MAP3K70.42881343
52PDPK10.40556753
53LATS10.39877516
54DYRK20.38979806
55PRKACB0.38641142
56PDK10.37086798
57RET0.35865608
58FER0.35349554
59NEK60.34761723
60IRAK40.34070787
61MAPK30.32169637
62CAMK1D0.31778281
63PRKCH0.30172198
64BRAF0.29757267
65KSR20.27974325
66CDK190.27163006
67MAP2K40.26897576
68CDK30.26863867
69MAP2K70.25092226
70FES0.23566577
71NEK10.23565164
72MAP3K40.21555474
73PRKCI0.20311613
74DDR20.19981786
75PRKD30.18484489
76ABL10.18099544
77PHKG10.17781597
78PHKG20.17781597
79CAMK2D0.17698542
80MAPK110.17646558
81MAPK70.17509818
82NTRK10.17049007
83PRKAA10.16380219
84GRK10.16165069
85MAPK10.16137745
86PRKACA0.13838805
87MAP3K20.13237556
88CDK50.12500055
89PRPF4B0.12498817
90PDK30.12234807
91PDK40.12234807
92PIM20.12169171
93MST1R0.11771260
94MAP3K10.11298212
95RPS6KA10.10979909
96EGFR0.09885834
97PRKCA0.08939107
98JAK20.08395983
99MAP3K30.08372693
100CSNK1E0.07897566

Predicted pathways (KEGG)

RankGene SetZ-score
1Pancreatic secretion_Homo sapiens_hsa049728.19899392
2Fat digestion and absorption_Homo sapiens_hsa049755.60462066
3Protein digestion and absorption_Homo sapiens_hsa049745.42791725
4Protein export_Homo sapiens_hsa030603.39049871
5Cyanoamino acid metabolism_Homo sapiens_hsa004603.17934974
6Folate biosynthesis_Homo sapiens_hsa007903.14412453
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.93488295
8Glycerolipid metabolism_Homo sapiens_hsa005612.83130347
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.45915466
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.20367369
11Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.07191903
12Propanoate metabolism_Homo sapiens_hsa006401.86431325
13Vitamin digestion and absorption_Homo sapiens_hsa049771.73232305
14Steroid biosynthesis_Homo sapiens_hsa001001.70261901
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46984567
16Arginine and proline metabolism_Homo sapiens_hsa003301.42633641
17Biosynthesis of amino acids_Homo sapiens_hsa012301.38858027
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36927404
19Renin-angiotensin system_Homo sapiens_hsa046141.30578241
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16792166
21Linoleic acid metabolism_Homo sapiens_hsa005911.14900827
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13978259
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.08977703
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05736626
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.01751750
26N-Glycan biosynthesis_Homo sapiens_hsa005100.91957548
27Primary bile acid biosynthesis_Homo sapiens_hsa001200.87999551
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85671800
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85418879
30beta-Alanine metabolism_Homo sapiens_hsa004100.78488041
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77649276
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73467974
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73282523
34Pyruvate metabolism_Homo sapiens_hsa006200.72949036
35Selenocompound metabolism_Homo sapiens_hsa004500.72759831
36Other glycan degradation_Homo sapiens_hsa005110.71682117
37Fructose and mannose metabolism_Homo sapiens_hsa000510.71138693
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68465876
39Starch and sucrose metabolism_Homo sapiens_hsa005000.67699530
40Influenza A_Homo sapiens_hsa051640.67584546
41One carbon pool by folate_Homo sapiens_hsa006700.66915278
42Notch signaling pathway_Homo sapiens_hsa043300.65975996
43Insulin secretion_Homo sapiens_hsa049110.64038935
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61867887
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60635929
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60152528
47Vibrio cholerae infection_Homo sapiens_hsa051100.56693207
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55558508
49Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55085463
50Arginine biosynthesis_Homo sapiens_hsa002200.55059504
51Parkinsons disease_Homo sapiens_hsa050120.54514544
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50338063
53Carbon metabolism_Homo sapiens_hsa012000.50198855
54Sulfur metabolism_Homo sapiens_hsa009200.49052499
55Arachidonic acid metabolism_Homo sapiens_hsa005900.47051811
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46495555
57Fatty acid degradation_Homo sapiens_hsa000710.44422559
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43519677
59Glutathione metabolism_Homo sapiens_hsa004800.43158570
60Metabolic pathways_Homo sapiens_hsa011000.41045328
61Alzheimers disease_Homo sapiens_hsa050100.40484192
62Sulfur relay system_Homo sapiens_hsa041220.37719625
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37047827
64Oxidative phosphorylation_Homo sapiens_hsa001900.36867488
65Tryptophan metabolism_Homo sapiens_hsa003800.35788041
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34643376
67GABAergic synapse_Homo sapiens_hsa047270.33976637
68Legionellosis_Homo sapiens_hsa051340.31263239
69Regulation of autophagy_Homo sapiens_hsa041400.30683385
70Calcium signaling pathway_Homo sapiens_hsa040200.28738257
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28612375
72Ether lipid metabolism_Homo sapiens_hsa005650.24306723
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22313197
74Lysosome_Homo sapiens_hsa041420.20117058
75Histidine metabolism_Homo sapiens_hsa003400.17670208
76Peroxisome_Homo sapiens_hsa041460.17480305
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.16962713
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15250798
79Chemical carcinogenesis_Homo sapiens_hsa052040.14969459
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.14318421
81Fatty acid metabolism_Homo sapiens_hsa012120.12741557
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.12164651
83Synaptic vesicle cycle_Homo sapiens_hsa047210.11849518
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.10953556
85Endometrial cancer_Homo sapiens_hsa052130.09557871
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.09097206
87VEGF signaling pathway_Homo sapiens_hsa043700.08657888
88Galactose metabolism_Homo sapiens_hsa000520.07143378
89Pentose phosphate pathway_Homo sapiens_hsa000300.06425151
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.05905231
91Butanoate metabolism_Homo sapiens_hsa006500.05208854
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.04895799
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.04427898
94Ribosome_Homo sapiens_hsa030100.02643598
95Bile secretion_Homo sapiens_hsa049760.02277304
96Huntingtons disease_Homo sapiens_hsa050160.02269749
97mTOR signaling pathway_Homo sapiens_hsa04150-0.0139096
98Circadian rhythm_Homo sapiens_hsa04710-0.0064313
99Phenylalanine metabolism_Homo sapiens_hsa00360-0.0050609
100Nitrogen metabolism_Homo sapiens_hsa00910-0.0028188

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