CABP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the CABP family of calcium binding protein characterized by four EF-hand motifs. Mutations in this gene are associated with congenital stationary night blindness type 2B. Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* visual perception (GO:0007601)8.34908075
2* sensory perception of light stimulus (GO:0050953)8.24654363
3retinal rod cell development (GO:0046548)8.14261391
4cellular response to light stimulus (GO:0071482)8.08301184
5regulation of cGMP metabolic process (GO:0030823)7.72840267
6photoreceptor cell differentiation (GO:0046530)7.45583361
7eye photoreceptor cell differentiation (GO:0001754)7.45583361
8protein-chromophore linkage (GO:0018298)7.42493909
9positive regulation of cGMP biosynthetic process (GO:0030828)7.10017453
10* detection of external stimulus (GO:0009581)6.88715887
11* detection of abiotic stimulus (GO:0009582)6.75348116
12regulation of cGMP biosynthetic process (GO:0030826)6.66256626
13retina development in camera-type eye (GO:0060041)6.61907037
14receptor guanylyl cyclase signaling pathway (GO:0007168)6.32391866
15positive regulation of cGMP metabolic process (GO:0030825)6.23159503
16detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)6.16508226
17positive regulation of synaptic transmission, dopaminergic (GO:0032226)6.09411042
18behavioral response to nicotine (GO:0035095)5.28775749
19cellular response to radiation (GO:0071478)5.25625160
20regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.11097769
21regulation of voltage-gated calcium channel activity (GO:1901385)4.91039928
22nonmotile primary cilium assembly (GO:0035058)4.85867521
23regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.70762960
24retina homeostasis (GO:0001895)4.59432871
25positive regulation of sodium ion transmembrane transporter activity (GO:2000651)4.54633863
26short-term memory (GO:0007614)4.53741419
27protein prenylation (GO:0018342)4.45336395
28prenylation (GO:0097354)4.45336395
29regulation of penile erection (GO:0060405)4.43973640
30regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.40580768
31regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.40580768
32fucose catabolic process (GO:0019317)4.39734784
33L-fucose metabolic process (GO:0042354)4.39734784
34L-fucose catabolic process (GO:0042355)4.39734784
35adaptation of signaling pathway (GO:0023058)4.29442953
36response to pheromone (GO:0019236)4.28761339
37chemosensory behavior (GO:0007635)4.18736477
38behavioral response to ethanol (GO:0048149)4.13415566
39response to histamine (GO:0034776)3.99119777
40platelet dense granule organization (GO:0060155)3.90140088
41* sensory perception (GO:0007600)3.86723373
42detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.85437265
43* response to light stimulus (GO:0009416)3.79545526
44DNA deamination (GO:0045006)3.72989270
45positive regulation of sodium ion transmembrane transport (GO:1902307)3.69668541
46protein heterotetramerization (GO:0051290)3.67008248
47indolalkylamine metabolic process (GO:0006586)3.66156584
48axoneme assembly (GO:0035082)3.65405590
49epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.64180730
50negative regulation of receptor-mediated endocytosis (GO:0048261)3.49368441
51detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.49151723
52regulation of clathrin-mediated endocytosis (GO:2000369)3.48227120
53sensory perception of smell (GO:0007608)3.47710599
54negative regulation of mast cell activation (GO:0033004)3.47474155
55tryptophan catabolic process (GO:0006569)3.47311282
56indole-containing compound catabolic process (GO:0042436)3.47311282
57indolalkylamine catabolic process (GO:0046218)3.47311282
58neural tube formation (GO:0001841)3.46309385
59behavioral response to cocaine (GO:0048148)3.44416137
60positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.43180284
61protein K11-linked deubiquitination (GO:0035871)3.40188842
62arachidonic acid secretion (GO:0050482)3.39108130
63icosanoid secretion (GO:0032309)3.39108130
64synaptic transmission, dopaminergic (GO:0001963)3.26848166
65protein polyglutamylation (GO:0018095)3.25703040
66positive regulation of neurotransmitter transport (GO:0051590)3.24662275
67preassembly of GPI anchor in ER membrane (GO:0016254)3.24051269
68epithelial cilium movement (GO:0003351)3.21926538
69respiratory chain complex IV assembly (GO:0008535)3.20410535
70piRNA metabolic process (GO:0034587)3.19064172
71water-soluble vitamin biosynthetic process (GO:0042364)3.18866797
72tryptophan metabolic process (GO:0006568)3.16752889
73protein complex biogenesis (GO:0070271)3.12841170
74negative regulation of cation channel activity (GO:2001258)3.12638234
75negative regulation of telomere maintenance (GO:0032205)3.11548474
76detection of chemical stimulus involved in sensory perception (GO:0050907)3.10707313
77cellular ketone body metabolic process (GO:0046950)3.09267229
78* neuron development (GO:0048666)3.08107877
79negative regulation of calcium ion transmembrane transport (GO:1903170)3.05914430
80negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.05914430
81kynurenine metabolic process (GO:0070189)3.04016041
82auditory receptor cell stereocilium organization (GO:0060088)3.03092430
83positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.00789419
84regulation of rhodopsin mediated signaling pathway (GO:0022400)20.1733834
85sulfation (GO:0051923)2.97591528
86ketone body metabolic process (GO:1902224)2.94931493
87mitochondrial respiratory chain complex I assembly (GO:0032981)2.93363358
88NADH dehydrogenase complex assembly (GO:0010257)2.93363358
89mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.93363358
90regulation of neurotransmitter uptake (GO:0051580)2.92513513
91cytochrome complex assembly (GO:0017004)2.92413635
92dopamine receptor signaling pathway (GO:0007212)2.91685860
93sensory perception of chemical stimulus (GO:0007606)2.90719455
94cilium morphogenesis (GO:0060271)2.89085698
95membrane hyperpolarization (GO:0060081)2.86124165
96protein-cofactor linkage (GO:0018065)2.85427164
97mitochondrial respiratory chain complex assembly (GO:0033108)2.85220740
98gamma-aminobutyric acid transport (GO:0015812)2.82369956
99reflex (GO:0060004)2.82213173
100CDP-diacylglycerol biosynthetic process (GO:0016024)2.82200132
101positive regulation of cyclase activity (GO:0031281)2.81050710
102regulation of action potential (GO:0098900)2.80797922
103regulation of cilium movement (GO:0003352)2.80332350
104dopamine transport (GO:0015872)2.78507782
105mannosylation (GO:0097502)2.75602755
106retinol metabolic process (GO:0042572)2.75171385
107retina layer formation (GO:0010842)2.74516698
108indole-containing compound metabolic process (GO:0042430)2.73084010
109icosanoid transport (GO:0071715)2.72969616
110fatty acid derivative transport (GO:1901571)2.72969616
111protein localization to synapse (GO:0035418)2.72516330
112cellular response to electrical stimulus (GO:0071257)2.72220736
113positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.72074959
114negative regulation of transcription regulatory region DNA binding (GO:2000678)2.72039912
115replication fork processing (GO:0031297)2.71505424
116reciprocal DNA recombination (GO:0035825)2.69955851
117reciprocal meiotic recombination (GO:0007131)2.69955851
118regulation of catecholamine metabolic process (GO:0042069)2.68581347
119regulation of dopamine metabolic process (GO:0042053)2.68581347
120neuronal action potential (GO:0019228)2.68473846
121glycerophospholipid catabolic process (GO:0046475)2.66531086
122cilium movement (GO:0003341)2.66506746
123* response to radiation (GO:0009314)2.66394039
124inner ear receptor stereocilium organization (GO:0060122)2.65800660
125cellular response to abiotic stimulus (GO:0071214)2.65799140
126cornea development in camera-type eye (GO:0061303)2.65321163
127CDP-diacylglycerol metabolic process (GO:0046341)2.65255308
128phosphatidylinositol acyl-chain remodeling (GO:0036149)2.64971298
129cilium organization (GO:0044782)2.63325469
130amine catabolic process (GO:0009310)2.63145275
131cellular biogenic amine catabolic process (GO:0042402)2.63145275
132nephron tubule morphogenesis (GO:0072078)2.63080514
133nephron epithelium morphogenesis (GO:0072088)2.63080514
134positive regulation of oligodendrocyte differentiation (GO:0048714)2.62426739
135S-adenosylmethionine metabolic process (GO:0046500)2.61001105
136multicellular organism reproduction (GO:0032504)2.59637794
137negative regulation of cytosolic calcium ion concentration (GO:0051481)2.57825241
138positive regulation of ERBB signaling pathway (GO:1901186)2.57743278
139retinoid metabolic process (GO:0001523)2.57713469
140anterograde synaptic vesicle transport (GO:0048490)2.56751438
141regulation of proton transport (GO:0010155)2.56593111
142DNA double-strand break processing (GO:0000729)2.56073292
143positive regulation of lyase activity (GO:0051349)2.55324667
144lipoprotein transport (GO:0042953)2.55182256
145cilium assembly (GO:0042384)2.53828395
146kidney morphogenesis (GO:0060993)2.52879705
147tachykinin receptor signaling pathway (GO:0007217)2.51402533
148positive regulation of defense response to virus by host (GO:0002230)2.49802129
149signal peptide processing (GO:0006465)2.49225731
150recombinational repair (GO:0000725)2.47911691
151regulation of glucokinase activity (GO:0033131)2.46724203
152regulation of hexokinase activity (GO:1903299)2.46724203
153protein localization to cilium (GO:0061512)2.46604271
154double-strand break repair via homologous recombination (GO:0000724)2.46474004
155somite development (GO:0061053)2.46303642
156cilium or flagellum-dependent cell motility (GO:0001539)2.45402930
157RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.44645871
158post-embryonic morphogenesis (GO:0009886)2.43791704
159cAMP catabolic process (GO:0006198)2.43707530
160regulation of synaptic transmission, dopaminergic (GO:0032225)2.42460769
161DNA methylation involved in gamete generation (GO:0043046)2.42034470
162primary amino compound metabolic process (GO:1901160)2.41236679
163positive regulation of membrane potential (GO:0045838)2.41191221
164negative regulation of synaptic transmission, GABAergic (GO:0032229)2.40374006
165rRNA catabolic process (GO:0016075)2.39492726
166G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.39097405
167GPI anchor metabolic process (GO:0006505)2.38544756
168phospholipid translocation (GO:0045332)2.37865449
169lipid translocation (GO:0034204)2.37865449
170sensory perception of taste (GO:0050909)2.36635325
171diterpenoid metabolic process (GO:0016101)2.36200534
172regulation of nuclear cell cycle DNA replication (GO:0033262)2.35952416
173transmission of nerve impulse (GO:0019226)2.35632437
174pyrimidine nucleobase catabolic process (GO:0006208)2.34862405
175embryonic epithelial tube formation (GO:0001838)2.34716245
176cellular response to leptin stimulus (GO:0044320)2.32675464
177rhodopsin mediated signaling pathway (GO:0016056)19.4186005
178positive regulation of guanylate cyclase activity (GO:0031284)12.3316461
179photoreceptor cell maintenance (GO:0045494)11.6357280
180* retinal cone cell development (GO:0046549)11.2521670
181regulation of guanylate cyclase activity (GO:0031282)11.1399715
182detection of light stimulus involved in visual perception (GO:0050908)11.0954459
183detection of light stimulus involved in sensory perception (GO:0050962)11.0954459
184* photoreceptor cell development (GO:0042461)11.0840809
185phototransduction, visible light (GO:0007603)10.7106266
186* phototransduction (GO:0007602)10.5703813
187GMP metabolic process (GO:0046037)10.4579433
188* eye photoreceptor cell development (GO:0042462)10.4453822
189detection of visible light (GO:0009584)10.0861680
190* detection of light stimulus (GO:0009583)10.0108443

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.03965115
2CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse5.35855790
3VDR_22108803_ChIP-Seq_LS180_Human5.15487943
4ZNF274_21170338_ChIP-Seq_K562_Hela3.85548835
5DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.52253119
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.44088566
7GBX2_23144817_ChIP-Seq_PC3_Human2.99162015
8IGF1R_20145208_ChIP-Seq_DFB_Human2.84090399
9EZH2_22144423_ChIP-Seq_EOC_Human2.63604269
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.57016882
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46117405
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.43036539
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36389349
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.31836258
15DROSHA_22980978_ChIP-Seq_HELA_Human2.17286080
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13149472
17EWS_26573619_Chip-Seq_HEK293_Human2.12562992
18FUS_26573619_Chip-Seq_HEK293_Human2.12317279
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.10410353
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.06792137
21CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.05938406
22BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.03516116
23P300_19829295_ChIP-Seq_ESCs_Human2.00412734
24CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00146916
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98918945
26NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.96022924
27TAF15_26573619_Chip-Seq_HEK293_Human1.94423042
28ER_23166858_ChIP-Seq_MCF-7_Human1.94274452
29KDM2B_26808549_Chip-Seq_K562_Human1.87032733
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86428041
31SMC4_20622854_ChIP-Seq_HELA_Human1.84313923
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.82364910
33GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.76499277
34BCAT_22108803_ChIP-Seq_LS180_Human1.75606738
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.74856197
36ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.73192476
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.71026195
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.70249124
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70082806
40MYC_22102868_ChIP-Seq_BL_Human1.65429691
41VDR_21846776_ChIP-Seq_THP-1_Human1.63664051
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61834225
43P68_20966046_ChIP-Seq_HELA_Human1.60666218
44TP53_22573176_ChIP-Seq_HFKS_Human1.59923088
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58691579
46TCF4_18268006_ChIP-ChIP_LS174T_Human1.56586929
47* CTCF_20526341_ChIP-Seq_ESCs_Human1.55924823
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.55864585
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55632220
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55509450
51CBP_20019798_ChIP-Seq_JUKART_Human1.55509450
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54392681
53ELK4_26923725_Chip-Seq_MESODERM_Mouse1.54372181
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.52938945
55BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.51609845
56SMAD3_21741376_ChIP-Seq_HESCs_Human1.51160878
57TAF2_19829295_ChIP-Seq_ESCs_Human1.50738802
58GABP_17652178_ChIP-ChIP_JURKAT_Human1.50106718
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49965280
60ERG_20517297_ChIP-Seq_VCAP_Human1.48814687
61NCOR_22424771_ChIP-Seq_293T_Human1.48346847
62LXR_22292898_ChIP-Seq_THP-1_Human1.47779538
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47296421
64STAT3_23295773_ChIP-Seq_U87_Human1.47111561
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.46471829
66AR_25329375_ChIP-Seq_VCAP_Human1.45765620
67SA1_27219007_Chip-Seq_Bcells_Human1.45238298
68CTCF_27219007_Chip-Seq_Bcells_Human1.44631191
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43256868
70MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.41781932
71CREB1_26743006_Chip-Seq_LNCaP_Human1.40173018
72SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.39822842
73SMAD4_21799915_ChIP-Seq_A2780_Human1.39757986
74IRF1_19129219_ChIP-ChIP_H3396_Human1.39103931
75NANOG_19829295_ChIP-Seq_ESCs_Human1.38109133
76SOX2_19829295_ChIP-Seq_ESCs_Human1.38109133
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.37383590
78FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37383590
79TCF4_23295773_ChIP-Seq_U87_Human1.36946871
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36893917
81MYC_18940864_ChIP-ChIP_HL60_Human1.36699563
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36362514
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36362514
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35782914
85CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.35266045
86KDM2B_26808549_Chip-Seq_JURKAT_Human1.34114272
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33401852
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.33261211
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32786479
90EZH2_27294783_Chip-Seq_NPCs_Mouse1.32625640
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.32434588
92TCF4_22108803_ChIP-Seq_LS180_Human1.31854698
93REST_18959480_ChIP-ChIP_MESCs_Mouse1.31748618
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30496733
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29699328
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.28454280
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26998210
98GATA3_21878914_ChIP-Seq_MCF-7_Human1.26633126
99DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25368464
100KDM2B_26808549_Chip-Seq_DND41_Human1.25304523
101CBX2_27304074_Chip-Seq_ESCs_Mouse1.23645968
102SMAD3_21741376_ChIP-Seq_EPCs_Human1.23053621
103HTT_18923047_ChIP-ChIP_STHdh_Human1.22828047
104EST1_17652178_ChIP-ChIP_JURKAT_Human1.22478293
105FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22333417
106RUNX2_22187159_ChIP-Seq_PCA_Human1.21620553
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21593069
108GATA1_19941827_ChIP-Seq_MEL_Mouse1.21512504
109CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20722464
110RUNX_20019798_ChIP-Seq_JUKART_Human1.20317498
111BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19988789
112AR_20517297_ChIP-Seq_VCAP_Human1.19745110
113AR_21572438_ChIP-Seq_LNCaP_Human1.19693121
114AR_19668381_ChIP-Seq_PC3_Human1.18835434
115TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18063178
116ETV2_25802403_ChIP-Seq_MESCs_Mouse1.17672901
117KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.16847511
118FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.16390015
119E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15927585
120KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15591380
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.14281227
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14263167
123SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14105058
124OCT4_19829295_ChIP-Seq_ESCs_Human1.13828322
125E2F1_20622854_ChIP-Seq_HELA_Human1.12866299
126YY1_22570637_ChIP-Seq_MALME-3M_Human1.12604167
127RNF2_27304074_Chip-Seq_NSC_Mouse1.12427427
128ERG_21242973_ChIP-ChIP_JURKAT_Human1.12074719
129SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11993420
130CRX_20693478_ChIP-Seq_RETINA_Mouse1.11904338
131SMAD4_21741376_ChIP-Seq_EPCs_Human1.11191227
132HOXB7_26014856_ChIP-Seq_BT474_Human1.10836872
133CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09929992
134ERA_21632823_ChIP-Seq_H3396_Human1.09772913
135ZNF263_19887448_ChIP-Seq_K562_Human1.09227112
136SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09184813
137RARB_27405468_Chip-Seq_BRAIN_Mouse1.08583202
138NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06648439
139CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06481593
140RXRA_24833708_ChIP-Seq_LIVER_Mouse1.06286258
141SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06267598
142HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05381894
143OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05331463
144AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05301119
145GATA1_26923725_Chip-Seq_HPCs_Mouse1.04911753
146NANOG_20526341_ChIP-Seq_ESCs_Human1.04449435
147P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.04045712
148P53_22387025_ChIP-Seq_ESCs_Mouse1.03436595
149WDR5_24793694_ChIP-Seq_LNCAP_Human1.03338087
150SCL_19346495_ChIP-Seq_HPC-7_Human1.03314002
151RING1B_27294783_Chip-Seq_NPCs_Mouse1.03277552
152EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03182002
153VDR_23849224_ChIP-Seq_CD4+_Human1.03011941
154ELK1_19687146_ChIP-ChIP_HELA_Human1.01829960
155NANOG_18555785_Chip-Seq_ESCs_Mouse1.01684608
156IRF8_22096565_ChIP-ChIP_GC-B_Human1.00757920
157RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00251322
158GATA2_21666600_ChIP-Seq_HMVEC_Human0.99216750
159TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98597797
160MYC_19829295_ChIP-Seq_ESCs_Human0.98593724
161VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97542163
162CDX2_22108803_ChIP-Seq_LS180_Human0.97494937
163EGR1_19032775_ChIP-ChIP_M12_Human0.97217551
164TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96697771
165EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96293591
166CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96266782
167KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95276897
168DPY_21335234_ChIP-Seq_ESCs_Mouse0.94500679
169TP63_22573176_ChIP-Seq_HFKS_Human0.94010887
170GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93028250
171SMAD4_21741376_ChIP-Seq_ESCs_Human0.92921044
172RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91805824
173CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91194037
174SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89945156
175SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.89782669
176EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87642019
177LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.87267109
178SA1_27219007_Chip-Seq_ERYTHROID_Human0.87208131
179REST_21632747_ChIP-Seq_MESCs_Mouse0.87103853
180SUZ12_27294783_Chip-Seq_ESCs_Mouse0.85532524
181KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85300506
182STAT1_17558387_ChIP-Seq_HELA_Human0.85116387
183PRDM14_20953172_ChIP-Seq_ESCs_Human0.84748835
184TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84656094
185VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.83909375
186PHF8_20622854_ChIP-Seq_HELA_Human0.81885994
187GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.81447817
188E2F1_17053090_ChIP-ChIP_MCF-7_Human0.80587287
189BCL6_27268052_Chip-Seq_Bcells_Human0.80331198
190TBL1_22424771_ChIP-Seq_293T_Human0.79836157
191CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79649879
192CBP_21632823_ChIP-Seq_H3396_Human0.79625457
193SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.79561117
194P53_22127205_ChIP-Seq_FIBROBLAST_Human0.78841982

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog9.80327782
2* MP0005253_abnormal_eye_physiology6.63262170
3MP0006072_abnormal_retinal_apoptosis6.33834003
4MP0003950_abnormal_plasma_membrane4.43490250
5MP0001986_abnormal_taste_sensitivity3.89386841
6* MP0005195_abnormal_posterior_eye3.73117750
7MP0005423_abnormal_somatic_nervous3.48788953
8MP0001324_abnormal_eye_pigmentation3.40764874
9* MP0005391_vision/eye_phenotype3.13816265
10MP0002638_abnormal_pupillary_reflex3.10525181
11MP0008877_abnormal_DNA_methylation2.78889306
12MP0003195_calcinosis2.55873360
13MP0002102_abnormal_ear_morphology2.52927500
14MP0003136_yellow_coat_color2.47480134
15MP0002090_abnormal_vision2.46351451
16MP0002229_neurodegeneration2.43350984
17MP0001764_abnormal_homeostasis2.33366012
18MP0000569_abnormal_digit_pigmentation2.29015049
19MP0002837_dystrophic_cardiac_calcinosis2.12967318
20MP0000372_irregular_coat_pigmentation2.09377162
21MP0003787_abnormal_imprinting2.06307947
22MP0003011_delayed_dark_adaptation10.8261139
23MP0008875_abnormal_xenobiotic_pharmacok1.99164058
24MP0002736_abnormal_nociception_after1.95087849
25MP0002876_abnormal_thyroid_physiology1.92943602
26MP0001501_abnormal_sleep_pattern1.92551374
27MP0008872_abnormal_physiological_respon1.82093549
28MP0005174_abnormal_tail_pigmentation1.81898683
29MP0005645_abnormal_hypothalamus_physiol1.78226336
30* MP0002752_abnormal_somatic_nervous1.77736834
31MP0001984_abnormal_olfaction1.69317784
32MP0005646_abnormal_pituitary_gland1.68808439
33MP0005075_abnormal_melanosome_morpholog1.55976597
34MP0001485_abnormal_pinna_reflex1.49269237
35MP0002938_white_spotting1.42504449
36MP0000427_abnormal_hair_cycle1.40658297
37MP0004133_heterotaxia1.34431186
38MP0002234_abnormal_pharynx_morphology1.31360069
39MP0006276_abnormal_autonomic_nervous1.31192270
40MP0003878_abnormal_ear_physiology1.27990210
41MP0005377_hearing/vestibular/ear_phenot1.27990210
42* MP0002882_abnormal_neuron_morphology1.23087820
43MP0005171_absent_coat_pigmentation1.22684552
44MP0002127_abnormal_cardiovascular_syste1.21142829
45MP0001970_abnormal_pain_threshold1.19856949
46MP0004019_abnormal_vitamin_homeostasis1.18920532
47MP0002735_abnormal_chemical_nociception1.18774281
48MP0010386_abnormal_urinary_bladder1.18336782
49MP0002557_abnormal_social/conspecific_i1.17250105
50MP0002163_abnormal_gland_morphology1.17023568
51MP0004742_abnormal_vestibular_system1.16850924
52MP0008995_early_reproductive_senescence1.15149722
53MP0005197_abnormal_uvea_morphology1.14691624
54MP0002254_reproductive_system_inflammat1.14565595
55MP0002733_abnormal_thermal_nociception1.09664606
56MP0002095_abnormal_skin_pigmentation1.08778987
57MP0005389_reproductive_system_phenotype1.07753555
58MP0005410_abnormal_fertilization1.06121983
59MP0001919_abnormal_reproductive_system1.05106812
60MP0005379_endocrine/exocrine_gland_phen1.04745763
61MP0004233_abnormal_muscle_weight1.02922502
62MP0002332_abnormal_exercise_endurance1.02749385
63MP0005394_taste/olfaction_phenotype0.99844209
64MP0005499_abnormal_olfactory_system0.99844209
65MP0000015_abnormal_ear_pigmentation0.99082714
66MP0002277_abnormal_respiratory_mucosa0.98162615
67MP0002653_abnormal_ependyma_morphology0.97596077
68MP0005187_abnormal_penis_morphology0.96560664
69MP0008789_abnormal_olfactory_epithelium0.92608991
70MP0003718_maternal_effect0.89773479
71MP0003283_abnormal_digestive_organ0.88319245
72MP0001529_abnormal_vocalization0.86900265
73MP0002160_abnormal_reproductive_system0.86760078
74MP0003121_genomic_imprinting0.84290927
75MP0005167_abnormal_blood-brain_barrier0.83489053
76MP0003698_abnormal_male_reproductive0.81685751
77MP0000383_abnormal_hair_follicle0.81348301
78MP0008775_abnormal_heart_ventricle0.79591610
79MP0002909_abnormal_adrenal_gland0.79119309
80MP0002751_abnormal_autonomic_nervous0.78291349
81MP0005085_abnormal_gallbladder_physiolo0.77965259
82MP0005332_abnormal_amino_acid0.77558495
83MP0004147_increased_porphyrin_level0.77360354
84MP0004885_abnormal_endolymph0.76206564
85MP0002272_abnormal_nervous_system0.72948487
86MP0003634_abnormal_glial_cell0.71974291
87MP0003646_muscle_fatigue0.62359581
88MP0005376_homeostasis/metabolism_phenot0.60786599
89MP0008058_abnormal_DNA_repair0.59049153
90MP0001661_extended_life_span0.58559071
91MP0001502_abnormal_circadian_rhythm0.57559865
92MP0003045_fibrosis0.54414918
93MP0004270_analgesia0.54386103
94MP0005076_abnormal_cell_differentiation0.49681803
95MP0004145_abnormal_muscle_electrophysio0.45506296
96MP0001486_abnormal_startle_reflex0.39977808
97MP0001286_abnormal_eye_development0.39734815
98MP0003638_abnormal_response/metabolism_0.39533650
99MP0002734_abnormal_mechanical_nocicepti0.39260810
100MP0005595_abnormal_vascular_smooth0.37347587
101MP0009046_muscle_twitch0.36314200
102MP0003252_abnormal_bile_duct0.34893711
103MP0005310_abnormal_salivary_gland0.34334045
104MP0004782_abnormal_surfactant_physiolog0.33262071
105MP0005620_abnormal_muscle_contractility0.32554354
106MP0004142_abnormal_muscle_tone0.30184349
107MP0001963_abnormal_hearing_physiology0.30082180
108MP0001905_abnormal_dopamine_level0.29891674
109MP0006292_abnormal_olfactory_placode0.29265537
110MP0002064_seizures0.26995672
111MP0000767_abnormal_smooth_muscle0.26188402
112MP0002168_other_aberrant_phenotype0.25359817
113MP0004085_abnormal_heartbeat0.24352174
114MP0002928_abnormal_bile_duct0.24274565
115MP0000465_gastrointestinal_hemorrhage0.23336007
116MP0002108_abnormal_muscle_morphology0.22794663
117MP0005266_abnormal_metabolism0.22606092
118MP0002067_abnormal_sensory_capabilities0.21770329
119MP0009780_abnormal_chondrocyte_physiolo0.21645874
120MP0004859_abnormal_synaptic_plasticity0.21483974
121MP0002572_abnormal_emotion/affect_behav0.20895193
122MP0010352_gastrointestinal_tract_polyps0.20173079
123MP0004215_abnormal_myocardial_fiber0.19727514
124MP0005084_abnormal_gallbladder_morpholo0.19248610
125MP0001915_intracranial_hemorrhage0.18136700
126MP0003635_abnormal_synaptic_transmissio0.17907736
127MP0005319_abnormal_enzyme/_coenzyme0.17898357
128MP0000003_abnormal_adipose_tissue0.17590313
129MP0000751_myopathy0.17548594
130MP0008873_increased_physiological_sensi0.16245289
131MP0002063_abnormal_learning/memory/cond0.16224268
132MP0005193_abnormal_anterior_eye0.14875895
133MP0002138_abnormal_hepatobiliary_system0.14489491
134MP0004811_abnormal_neuron_physiology0.14403796
135MP0009745_abnormal_behavioral_response0.13526203
136MP0003880_abnormal_central_pattern0.12940435
137MP0001968_abnormal_touch/_nociception0.12746742
138MP0004043_abnormal_pH_regulation0.12404975
139MP0005584_abnormal_enzyme/coenzyme_acti0.11961066
140MP0000026_abnormal_inner_ear0.11687138
141MP0000631_abnormal_neuroendocrine_gland0.11484813
142MP0000750_abnormal_muscle_regeneration0.11120167
143MP0000230_abnormal_systemic_arterial0.10744036
144MP0005501_abnormal_skin_physiology0.10073444
145MP0002152_abnormal_brain_morphology0.09436115
146MP0005386_behavior/neurological_phenoty0.09412650
147MP0004924_abnormal_behavior0.09412650
148MP0005330_cardiomyopathy0.08656150
149MP0005365_abnormal_bile_salt0.07771089
150MP0002089_abnormal_postnatal_growth/wei0.07596999
151MP0005334_abnormal_fat_pad0.07390973
152MP0002066_abnormal_motor_capabilities/c0.07296665
153MP0001614_abnormal_blood_vessel0.07269127
154MP0009764_decreased_sensitivity_to0.06916361
155MP0001542_abnormal_bone_strength0.06670871
156MP0010329_abnormal_lipoprotein_level0.06343628

Predicted human phenotypes

RankGene SetZ-score
1Chorioretinal atrophy (HP:0000533)9.11972582
2Attenuation of retinal blood vessels (HP:0007843)8.35472213
3Pendular nystagmus (HP:0012043)7.36953198
4Central scotoma (HP:0000603)7.12193930
5Abnormality of macular pigmentation (HP:0008002)6.87306878
6Dyschromatopsia (HP:0007641)6.70788754
7Scotoma (HP:0000575)6.53276759
8Type II diabetes mellitus (HP:0005978)6.20835428
9Decreased central vision (HP:0007663)6.10271727
10Photophobia (HP:0000613)5.91493001
11Abolished electroretinogram (ERG) (HP:0000550)5.67538371
12Macular degeneration (HP:0000608)4.89228488
13Retinitis pigmentosa (HP:0000510)4.85498078
14Vitreoretinal degeneration (HP:0000655)4.80921673
15Choroideremia (HP:0001139)4.75614268
16Increased corneal curvature (HP:0100692)4.74917918
17Keratoconus (HP:0000563)4.74917918
18Cone-rod dystrophy (HP:0000548)4.24124960
19Severe visual impairment (HP:0001141)3.77525774
20Decreased electroretinogram (ERG) amplitude (HP:0000654)3.77047080
21Nephronophthisis (HP:0000090)3.75947401
22Constricted visual fields (HP:0001133)3.68284157
23Abnormality of the renal cortex (HP:0011035)3.48428775
24Posterior subcapsular cataract (HP:0007787)3.48147443
25Abnormality of the renal medulla (HP:0100957)3.32955715
26Hyperventilation (HP:0002883)3.17988810
27Type II lissencephaly (HP:0007260)3.16073116
28Progressive visual loss (HP:0000529)2.92441932
29Renal cortical cysts (HP:0000803)2.86731242
30Optic disc pallor (HP:0000543)2.76783042
31Wide nasal bridge (HP:0000431)2.76373999
32Gait imbalance (HP:0002141)2.76278176
33Congenital primary aphakia (HP:0007707)2.75058671
34Retinal atrophy (HP:0001105)2.71023995
35Polydipsia (HP:0001959)2.63221614
36Abnormal drinking behavior (HP:0030082)2.63221614
37Tubular atrophy (HP:0000092)2.54525034
38Sclerocornea (HP:0000647)2.43099128
39Progressive inability to walk (HP:0002505)2.42676618
40Nephrogenic diabetes insipidus (HP:0009806)2.40215011
41Inability to walk (HP:0002540)2.34011908
42Stomach cancer (HP:0012126)2.32513049
43Gaze-evoked nystagmus (HP:0000640)2.31710192
443-Methylglutaconic aciduria (HP:0003535)2.29675598
45Medial flaring of the eyebrow (HP:0010747)2.29655865
46Congenital hepatic fibrosis (HP:0002612)2.26381354
47Lissencephaly (HP:0001339)2.23167167
48Increased CSF lactate (HP:0002490)2.21355439
49Dynein arm defect of respiratory motile cilia (HP:0012255)2.21271770
50Absent/shortened dynein arms (HP:0200106)2.21271770
51Abnormal biliary tract physiology (HP:0012439)2.18640439
52Bile duct proliferation (HP:0001408)2.18640439
53Polyuria (HP:0000103)2.15984573
54Large for gestational age (HP:0001520)2.14706090
55Mitochondrial inheritance (HP:0001427)2.14199066
56Acute necrotizing encephalopathy (HP:0006965)2.11098515
57Poor coordination (HP:0002370)2.08887617
58Anencephaly (HP:0002323)2.07529883
59Aplasia/Hypoplasia of the tibia (HP:0005772)2.07310976
60Decreased circulating renin level (HP:0003351)2.07075727
61Hemiparesis (HP:0001269)2.06014926
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05581996
63Abnormality of alanine metabolism (HP:0010916)2.05581996
64Hyperalaninemia (HP:0003348)2.05581996
65Methylmalonic acidemia (HP:0002912)2.05518118
66Methylmalonic aciduria (HP:0012120)2.04460720
67Intestinal atresia (HP:0011100)2.03784745
68Hypothermia (HP:0002045)2.03549117
69Acute encephalopathy (HP:0006846)2.01752203
70Fair hair (HP:0002286)2.01354116
71Pachygyria (HP:0001302)2.00875431
72Oligodactyly (hands) (HP:0001180)2.00548533
73* Congenital stationary night blindness (HP:0007642)16.7815300
74Bony spicule pigmentary retinopathy (HP:0007737)12.5064867
75Abnormal rod and cone electroretinograms (HP:0008323)10.5436060
76Pigmentary retinal degeneration (HP:0001146)10.4664824
77Absent rod-and cone-mediated responses on ERG (HP:0007688)10.4012276
78Male pseudohermaphroditism (HP:0000037)1.98763473
79Aplasia/Hypoplasia of the spleen (HP:0010451)1.97333026
80Subcapsular cataract (HP:0000523)1.97314340
81Congenital, generalized hypertrichosis (HP:0004540)1.97064633
82Progressive macrocephaly (HP:0004481)1.94675999
83Interstitial pulmonary disease (HP:0006530)1.93633711
84Postaxial foot polydactyly (HP:0001830)1.92647582
85Rib fusion (HP:0000902)1.88315679
86Abnormal respiratory motile cilium morphology (HP:0005938)1.87602595
87Abnormal respiratory epithelium morphology (HP:0012253)1.87602595
88Absent speech (HP:0001344)1.87254301
89Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87205147
90Colon cancer (HP:0003003)1.86747719
91Optic nerve hypoplasia (HP:0000609)1.86313214
92Congenital sensorineural hearing impairment (HP:0008527)1.86220788
93Retinal dysplasia (HP:0007973)1.85129807
94Stomatitis (HP:0010280)1.84483680
95Vaginal atresia (HP:0000148)1.83081507
96Asplenia (HP:0001746)1.82841255
97Concave nail (HP:0001598)1.82771800
98Broad-based gait (HP:0002136)1.82654011
99Abnormal ciliary motility (HP:0012262)1.76001991
100Optic atrophy (HP:0000648)1.75990494
101Lipid accumulation in hepatocytes (HP:0006561)1.75693734
102Hepatocellular necrosis (HP:0001404)1.75118343
103Hypomagnesemia (HP:0002917)1.75117251
104Focal motor seizures (HP:0011153)1.74875739
105Genital tract atresia (HP:0001827)1.73774266
106Protruding tongue (HP:0010808)1.72423511
107True hermaphroditism (HP:0010459)1.72214443
108Recurrent sinusitis (HP:0011108)1.51122223
109Aplasia/Hypoplasia of the lens (HP:0008063)1.45540673
110Cerebellar dysplasia (HP:0007033)1.39688489
111Abnormal sex determination (HP:0012244)1.37217368
112Sex reversal (HP:0012245)1.37217368
113Dysdiadochokinesis (HP:0002075)1.19248523
114Horizontal nystagmus (HP:0000666)1.17455163
115Broad foot (HP:0001769)1.16562498
116Decreased testicular size (HP:0008734)1.16290382
117Left ventricular hypertrophy (HP:0001712)1.10020073
118Retinal detachment (HP:0000541)1.09756417
119Astigmatism (HP:0000483)1.07642037
120Specific learning disability (HP:0001328)1.07432382
121Asthma (HP:0002099)1.06989345
122Polar cataract (HP:0010696)0.98925620
123Partial agenesis of the corpus callosum (HP:0001338)0.97338164
124Pancreatic fibrosis (HP:0100732)0.96956927
125Severe Myopia (HP:0011003)0.96067872
126Abnormality of the fovea (HP:0000493)0.95354547
127Hypoplasia of the fovea (HP:0007750)0.92787481
128Aplasia/Hypoplasia of the fovea (HP:0008060)0.92787481
129Lymphopenia (HP:0001888)0.89742291
130Heterotopia (HP:0002282)0.89694757
131Epileptic encephalopathy (HP:0200134)0.87899045
132Cystic liver disease (HP:0006706)0.86246993
133Vertebral clefting (HP:0008428)0.85087377
134Abnormality of cells of the lymphoid lineage (HP:0012140)0.84092744
135Truncal ataxia (HP:0002078)0.81790686
136Recurrent otitis media (HP:0000403)0.78340427
137Osteomalacia (HP:0002749)0.78278075
138Aplasia/Hypoplasia of the macula (HP:0008059)0.77476185
139Abnormality of dental color (HP:0011073)0.77317756
140Dental crowding (HP:0000678)0.75830781
141Pancreatic cysts (HP:0001737)0.75583288
142Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.75451611
143Abnormal gallbladder physiology (HP:0012438)0.75382156
144Cholecystitis (HP:0001082)0.75382156
145Polycystic ovaries (HP:0000147)0.75110967
146Febrile seizures (HP:0002373)0.71136904
147Aplasia/Hypoplasia affecting the retina (HP:0008061)0.70625939
148Hypodontia (HP:0000668)0.68791110
149Short foot (HP:0001773)0.68776348
150Chorioretinal coloboma (HP:0000567)0.68520725
151Visual hallucinations (HP:0002367)0.68454432
152Hypermetropia (HP:0000540)0.66159938
153Progressive cerebellar ataxia (HP:0002073)0.64290068
154Postaxial hand polydactyly (HP:0001162)0.62665672
155Hirsutism (HP:0001007)0.62422490
156Nephrotic syndrome (HP:0000100)0.61813817
157Chronic hepatic failure (HP:0100626)0.61806617
158Aplasia/Hypoplasia of the tongue (HP:0010295)0.61414157
159Sensorimotor neuropathy (HP:0007141)0.59937454
160Furrowed tongue (HP:0000221)0.59924760
161Hypoglycemic seizures (HP:0002173)0.59579383
162Abnormality of midbrain morphology (HP:0002418)0.58240432
163Molar tooth sign on MRI (HP:0002419)0.58240432
164Long foot (HP:0001833)0.57543825

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK9.63242136
2GRK19.36637869
3FRK5.28985252
4CCNB13.96723615
5MAP4K23.43633005
6WNK33.08593386
7ADRBK22.96494785
8NUAK12.66120322
9BMPR1B2.58899970
10TXK2.47546270
11ZAK2.42443845
12INSRR2.23318756
13IRAK22.14463783
14ACVR1B2.10339282
15TLK12.06950644
16MAPK132.05289951
17WNK42.01997270
18ICK2.01886566
19RPS6KA41.98554531
20CASK1.83437963
21MAPK71.79331069
22PINK11.70645913
23NEK11.64664489
24NEK21.54783940
25ADRBK11.54690824
26MAP3K101.54624632
27SIK21.53205250
28CDK121.52259079
29OXSR11.51573148
30TAOK31.48798844
31STK391.45802089
32MUSK1.39231226
33TNIK1.34134364
34BCKDK1.30118799
35PHKG11.25467251
36PHKG21.25467251
37PAK31.20399895
38TTK1.19382694
39CAMK1G1.18182019
40MAPK151.16329249
41MAPK121.14234351
42TRIM281.13891655
43CAMK1D1.13760007
44RPS6KB21.08532881
45CDK31.03204650
46BRD41.02891178
47TIE11.02146409
48MST41.00135114
49MAPKAPK30.99708175
50CAMKK20.98323133
51DYRK20.96520828
52TGFBR10.92695442
53BLK0.91130344
54CSNK1D0.91064493
55HIPK20.90496812
56VRK10.89082849
57TEC0.89049337
58DAPK20.88021099
59PRKCE0.87198563
60MAP2K70.86565732
61CSNK1G20.86268697
62MAP2K60.84957034
63SCYL20.81113184
64ERBB30.79868131
65IKBKB0.79126797
66STK38L0.77042563
67IRAK10.76289227
68CSNK1G10.75267212
69NME10.73011543
70KIT0.72867245
71CSNK1G30.72630569
72PNCK0.72226172
73BRSK20.72034460
74TNK20.70189133
75PTK2B0.68786462
76PRKACG0.68135236
77PLK20.67756212
78PRKCH0.67208366
79PRKCQ0.66177620
80ITK0.65828148
81STK380.65490403
82BCR0.64886979
83CSNK1A1L0.64263731
84PAK60.63492171
85NEK60.63234732
86NTRK20.63016903
87SGK4940.60914518
88SGK2230.60914518
89PRKAA10.60669950
90MAPKAPK50.60223899
91FGFR20.60176321
92AKT20.60129641
93CHEK20.58673334
94MKNK10.58449666
95MARK10.58375825
96RPS6KA50.58259833
97PDGFRB0.57710129
98STK30.54848416
99ERN10.53391292
100PKN10.52967747
101MAP2K20.52748021
102PRKCB0.52718657
103PIK3CA0.48975766
104FES0.46591214
105EPHA40.46398594
106FER0.45893052
107WNK10.44953354
108RPS6KA30.43910534
109PRKDC0.43058331
110RPS6KB10.42408145
111PRKAA20.41914140
112IKBKE0.41565874
113NLK0.41088001
114CSNK1A10.40242822
115PRKCG0.40087559
116CAMKK10.39729684
117PLK40.39111691
118EPHA30.39014634
119AKT30.38738187
120MAP4K10.37594747
121MARK30.36364385
122CDK70.35954572
123MAPK90.35723384
124CAMK2D0.35631418
125MAP3K40.35425272
126GRK70.35095818
127NTRK30.34723392
128FLT30.34469200
129PRKG10.34075680
130GRK50.33825576
131CDK80.32970022
132CAMK2A0.32838528
133ERBB20.32127143
134PRKD30.31831573
135STK110.30870927
136MAPK140.30647070
137LYN0.30448741
138SGK30.29619670
139PDK20.29514207
140ALK0.29237773
141GSK3B0.27617789
142MKNK20.27052277
143PLK30.26963870
144DYRK1A0.26597023
145CHUK0.26325041
146CAMK10.25983674
147GRK60.25877673
148MAP3K70.25867471
149PRKD20.25734560
150DYRK1B0.25181103
151* PRKCZ0.24134809
152PRKCA0.23864949
153PRKACA0.23559030
154CHEK10.22984038
155JAK10.22094664
156YES10.21989644
157CSNK1E0.21905255
158SGK20.21823738
159PLK10.21819639
160MAPK100.20569164
161CDK10.20364291
162PRKCI0.20073043
163SGK10.19292549
164ATR0.19192551
165MYLK0.18941676
166PDK10.18690115
167MAPK30.18103460
168CDK20.17427259
169CDK90.16328687
170SYK0.16083640
171SIK10.15236575
172MAP3K130.14571175

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005912.71909660
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.57699620
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.52570814
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.35038036
5Oxidative phosphorylation_Homo sapiens_hsa001902.26426232
6Butanoate metabolism_Homo sapiens_hsa006502.16434576
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.15955519
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11903755
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.10889047
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.10815075
11Phototransduction_Homo sapiens_hsa0474416.3191385
12Protein export_Homo sapiens_hsa030601.99448354
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.97813292
14Ether lipid metabolism_Homo sapiens_hsa005651.96789344
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.86858853
16Homologous recombination_Homo sapiens_hsa034401.84017540
17Parkinsons disease_Homo sapiens_hsa050121.74688368
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.69515238
19RNA polymerase_Homo sapiens_hsa030201.63906566
20Basal transcription factors_Homo sapiens_hsa030221.63223929
21Olfactory transduction_Homo sapiens_hsa047401.62031472
22Fanconi anemia pathway_Homo sapiens_hsa034601.61073175
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.60881117
24Tryptophan metabolism_Homo sapiens_hsa003801.56966167
25Propanoate metabolism_Homo sapiens_hsa006401.55993340
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.44212997
27Selenocompound metabolism_Homo sapiens_hsa004501.44039202
28Taste transduction_Homo sapiens_hsa047421.38733150
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37073303
30Synaptic vesicle cycle_Homo sapiens_hsa047211.33948711
31Arachidonic acid metabolism_Homo sapiens_hsa005901.19312552
32Chemical carcinogenesis_Homo sapiens_hsa052041.17230040
33Regulation of autophagy_Homo sapiens_hsa041401.12595775
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09954408
35Huntingtons disease_Homo sapiens_hsa050161.09909566
36Peroxisome_Homo sapiens_hsa041461.09588538
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.06864960
38One carbon pool by folate_Homo sapiens_hsa006701.05740016
39Alzheimers disease_Homo sapiens_hsa050101.03156870
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02987526
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02279519
42Retinol metabolism_Homo sapiens_hsa008300.95385618
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95372632
44Collecting duct acid secretion_Homo sapiens_hsa049660.94174018
45Asthma_Homo sapiens_hsa053100.93543434
46GABAergic synapse_Homo sapiens_hsa047270.88253181
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80184677
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76831771
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76707630
50Ovarian steroidogenesis_Homo sapiens_hsa049130.75380583
51Proteasome_Homo sapiens_hsa030500.74697587
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70752710
53beta-Alanine metabolism_Homo sapiens_hsa004100.70629444
54Cholinergic synapse_Homo sapiens_hsa047250.66524026
55Dopaminergic synapse_Homo sapiens_hsa047280.63176451
56Non-homologous end-joining_Homo sapiens_hsa034500.62969925
57Arginine biosynthesis_Homo sapiens_hsa002200.62737860
58Histidine metabolism_Homo sapiens_hsa003400.62485678
59Metabolic pathways_Homo sapiens_hsa011000.60680962
60Graft-versus-host disease_Homo sapiens_hsa053320.59460335
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58748992
62Morphine addiction_Homo sapiens_hsa050320.58412858
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57295200
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56797443
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56624047
66Allograft rejection_Homo sapiens_hsa053300.55748911
67Nitrogen metabolism_Homo sapiens_hsa009100.53289486
68Sulfur metabolism_Homo sapiens_hsa009200.53191667
69Autoimmune thyroid disease_Homo sapiens_hsa053200.52541390
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52347604
71Glutamatergic synapse_Homo sapiens_hsa047240.51803250
72Circadian entrainment_Homo sapiens_hsa047130.51110545
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50254419
74Mineral absorption_Homo sapiens_hsa049780.48028109
75Dorso-ventral axis formation_Homo sapiens_hsa043200.47879264
76Biosynthesis of amino acids_Homo sapiens_hsa012300.46770053
77ABC transporters_Homo sapiens_hsa020100.46626779
78Long-term depression_Homo sapiens_hsa047300.43388395
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42118662
80Circadian rhythm_Homo sapiens_hsa047100.41554387
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41184030
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39871198
83Purine metabolism_Homo sapiens_hsa002300.39842037
84Fructose and mannose metabolism_Homo sapiens_hsa000510.39219748
85Serotonergic synapse_Homo sapiens_hsa047260.38893035
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38562962
87mTOR signaling pathway_Homo sapiens_hsa041500.37305082
88Fatty acid degradation_Homo sapiens_hsa000710.36659126
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.36188833
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35760402
91Sulfur relay system_Homo sapiens_hsa041220.35429905
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34085154
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.33240116
94Pyrimidine metabolism_Homo sapiens_hsa002400.33100383
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.32429358
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31347800
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31119851
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30888178
99Hedgehog signaling pathway_Homo sapiens_hsa043400.30854312
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30215058
101Insulin secretion_Homo sapiens_hsa049110.29891711
102Base excision repair_Homo sapiens_hsa034100.27598882
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26862393
104Inositol phosphate metabolism_Homo sapiens_hsa005620.26035671
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.24065845
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.23551035
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23106753
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22895237
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.22320142
110cAMP signaling pathway_Homo sapiens_hsa040240.21860942
111Galactose metabolism_Homo sapiens_hsa000520.21098864
112Caffeine metabolism_Homo sapiens_hsa002320.20708011
113HIF-1 signaling pathway_Homo sapiens_hsa040660.20529130
114Oxytocin signaling pathway_Homo sapiens_hsa049210.20482951
115Type II diabetes mellitus_Homo sapiens_hsa049300.20019136
116Chemokine signaling pathway_Homo sapiens_hsa040620.19540479
117Glucagon signaling pathway_Homo sapiens_hsa049220.18785480
118Folate biosynthesis_Homo sapiens_hsa007900.17504694
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.17320165
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16205520
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.15896683
122Glycerolipid metabolism_Homo sapiens_hsa005610.15744614
123Dilated cardiomyopathy_Homo sapiens_hsa054140.15380021
124Alcoholism_Homo sapiens_hsa050340.15359135
125AMPK signaling pathway_Homo sapiens_hsa041520.14916397
126mRNA surveillance pathway_Homo sapiens_hsa030150.14902169
127Nicotine addiction_Homo sapiens_hsa050330.13149394
128Carbon metabolism_Homo sapiens_hsa012000.13094795
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.13064686
130Cardiac muscle contraction_Homo sapiens_hsa042600.12446525
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.12020656
132Lysine degradation_Homo sapiens_hsa003100.10982851
133Renin secretion_Homo sapiens_hsa049240.10950855
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.09739658
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.09592447
136Pyruvate metabolism_Homo sapiens_hsa006200.09570051
137Phenylalanine metabolism_Homo sapiens_hsa003600.09486194
138Salivary secretion_Homo sapiens_hsa049700.08626433
139Insulin resistance_Homo sapiens_hsa049310.08261183
140Vitamin B6 metabolism_Homo sapiens_hsa007500.07971749
141Gastric acid secretion_Homo sapiens_hsa049710.07810315
142Vitamin digestion and absorption_Homo sapiens_hsa049770.07746028
143Bile secretion_Homo sapiens_hsa049760.07549216
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.07399833
145Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.07295008
146Long-term potentiation_Homo sapiens_hsa047200.04504327
147Adipocytokine signaling pathway_Homo sapiens_hsa049200.03227009
148Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.02974802
149Spliceosome_Homo sapiens_hsa030400.02865165
150Calcium signaling pathway_Homo sapiens_hsa040200.02285013
151Pentose phosphate pathway_Homo sapiens_hsa000300.01958700
152Fatty acid elongation_Homo sapiens_hsa000620.01938971
153Cocaine addiction_Homo sapiens_hsa050300.00548026
154Ras signaling pathway_Homo sapiens_hsa040140.00420394
155Starch and sucrose metabolism_Homo sapiens_hsa005000.00110502
156MAPK signaling pathway_Homo sapiens_hsa04010-0.0251480
157GnRH signaling pathway_Homo sapiens_hsa04912-0.0239197
158Tight junction_Homo sapiens_hsa04530-0.0234587
159Pancreatic secretion_Homo sapiens_hsa04972-0.0229026
160Type I diabetes mellitus_Homo sapiens_hsa04940-0.0210778
161Insulin signaling pathway_Homo sapiens_hsa04910-0.0203630
162Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532-0.0200360
163Fat digestion and absorption_Homo sapiens_hsa04975-0.0165024
164Arginine and proline metabolism_Homo sapiens_hsa00330-0.0152467
165Notch signaling pathway_Homo sapiens_hsa04330-0.0110213
166B cell receptor signaling pathway_Homo sapiens_hsa04662-0.0055512
167Primary immunodeficiency_Homo sapiens_hsa05340-0.0008691
168RNA degradation_Homo sapiens_hsa03018-0.0003694

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