CABYR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm-egg recognition (GO:0035036)9.74043678
2multicellular organism reproduction (GO:0032504)9.73279152
3acrosome assembly (GO:0001675)9.66186593
4plasma membrane fusion (GO:0045026)9.21858660
5cilium or flagellum-dependent cell motility (GO:0001539)9.02476465
6* epithelial cilium movement (GO:0003351)8.99367169
7axonemal dynein complex assembly (GO:0070286)8.92426586
8cell-cell recognition (GO:0009988)8.70030868
9binding of sperm to zona pellucida (GO:0007339)8.69234710
10spermatid development (GO:0007286)8.55360375
11regulation of cilium movement (GO:0003352)8.28915118
12reproduction (GO:0000003)8.19737200
13motile cilium assembly (GO:0044458)8.04499649
14* cilium movement (GO:0003341)7.44454477
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.04642763
16single fertilization (GO:0007338)6.63499141
17piRNA metabolic process (GO:0034587)6.43462819
18negative regulation of inclusion body assembly (GO:0090084)6.41362466
19male meiosis (GO:0007140)6.22981342
20calcium ion-dependent exocytosis (GO:0017156)5.99118979
21* sperm capacitation (GO:0048240)5.98275955
22synaptonemal complex organization (GO:0070193)5.96558746
23response to pheromone (GO:0019236)5.93952153
24microtubule depolymerization (GO:0007019)5.77909048
25spermatogenesis (GO:0007283)5.69462943
26synaptonemal complex assembly (GO:0007130)5.67863574
27male gamete generation (GO:0048232)5.67375026
28organic cation transport (GO:0015695)5.61250958
29fertilization (GO:0009566)5.51242841
30ventricular system development (GO:0021591)5.30480761
31gamete generation (GO:0007276)5.22752363
32regulation of inclusion body assembly (GO:0090083)5.03018199
33regulation of microtubule-based movement (GO:0060632)4.96603547
34rRNA methylation (GO:0031167)4.93989789
35rRNA modification (GO:0000154)4.70169854
36cell recognition (GO:0008037)4.67831498
37germ cell development (GO:0007281)4.62775139
38centriole replication (GO:0007099)4.55924212
39microtubule severing (GO:0051013)4.47525905
40* cellular process involved in reproduction in multicellular organism (GO:0022412)4.46734725
41cellular ketone body metabolic process (GO:0046950)4.36997884
42protein localization to cilium (GO:0061512)4.34496159
43male meiosis I (GO:0007141)4.29643387
44glycerol ether metabolic process (GO:0006662)4.23522215
45multicellular organismal reproductive process (GO:0048609)4.09190245
46DNA methylation involved in gamete generation (GO:0043046)4.09172989
47spermatid nucleus differentiation (GO:0007289)3.99386221
48regulation of meiosis I (GO:0060631)3.94597384
49phosphatidylethanolamine biosynthetic process (GO:0006646)3.91596882
50ether metabolic process (GO:0018904)3.91042953
51ketone body metabolic process (GO:1902224)3.89130788
52left/right pattern formation (GO:0060972)3.88476557
53microtubule polymerization or depolymerization (GO:0031109)3.75890685
54chromosome organization involved in meiosis (GO:0070192)3.73894574
55phosphatidylethanolamine metabolic process (GO:0046337)3.73660444
56protein polyglutamylation (GO:0018095)3.70238378
57regulation of centriole replication (GO:0046599)3.61212086
58centriole assembly (GO:0098534)3.57799754
59seminiferous tubule development (GO:0072520)3.49196602
60glucose 6-phosphate metabolic process (GO:0051156)3.46155392
61establishment of protein localization to Golgi (GO:0072600)3.43492149
62protein targeting to Golgi (GO:0000042)3.40193843
63lactate metabolic process (GO:0006089)3.35386963
64meiotic nuclear division (GO:0007126)3.33648904
65histone exchange (GO:0043486)3.27781957
66alditol metabolic process (GO:0019400)3.27392264
67multicellular organismal development (GO:0007275)3.25286602
68meiosis I (GO:0007127)3.21763937
69behavioral response to nicotine (GO:0035095)3.20443362
70regulation of mesoderm development (GO:2000380)3.19156179
71nonmotile primary cilium assembly (GO:0035058)3.19045827
72polyol catabolic process (GO:0046174)3.10452471
73glycerol metabolic process (GO:0006071)3.04847212
74protein K11-linked deubiquitination (GO:0035871)3.04569436
75cullin deneddylation (GO:0010388)3.02620936
76spinal cord motor neuron differentiation (GO:0021522)2.99082961
77glycolytic process (GO:0006096)2.95890540
78cilium morphogenesis (GO:0060271)2.95508567
79protein deneddylation (GO:0000338)2.94358582
80retrograde transport, vesicle recycling within Golgi (GO:0000301)2.94279514
81resolution of meiotic recombination intermediates (GO:0000712)2.90902561
82chromosome condensation (GO:0030261)2.90543026
83ATP hydrolysis coupled proton transport (GO:0015991)2.89796587
84energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.89796587
85calcium ion import (GO:0070509)2.88255517
86nucleoside diphosphate phosphorylation (GO:0006165)2.86343919
87regulation of acrosome reaction (GO:0060046)2.85700747
88sexual reproduction (GO:0019953)2.82340366
89protein localization to Golgi apparatus (GO:0034067)2.82321526
90cilium organization (GO:0044782)2.82212657
91DNA packaging (GO:0006323)2.80115657
92chaperone-mediated protein complex assembly (GO:0051131)2.79607192
93peptidyl-glutamic acid modification (GO:0018200)2.78770280
94positive regulation of gastrulation (GO:2000543)2.78625475
95coenzyme catabolic process (GO:0009109)2.77404217
96cilium assembly (GO:0042384)2.76413894
97positive regulation of meiosis (GO:0045836)2.75462897
98* microtubule-based movement (GO:0007018)2.75136543
99intraciliary transport (GO:0042073)2.74038301
100genitalia morphogenesis (GO:0035112)2.73738499
101polyamine biosynthetic process (GO:0006596)2.73238202
102meiotic cell cycle process (GO:1903046)2.72543371
103somite rostral/caudal axis specification (GO:0032525)2.71246813
104membrane depolarization during action potential (GO:0086010)2.68177210
105axoneme assembly (GO:0035082)2.66275328
106response to methylmercury (GO:0051597)2.65845452
107negative regulation of telomere maintenance (GO:0032205)2.62376815
108GTP biosynthetic process (GO:0006183)2.62056175
109regulation of protein kinase A signaling (GO:0010738)2.62048727
110cellular component assembly involved in morphogenesis (GO:0010927)2.61700946
111positive regulation of meiotic cell cycle (GO:0051446)2.58912276
112regulation of female gonad development (GO:2000194)2.58879376
113protein refolding (GO:0042026)2.56463035
114urinary tract smooth muscle contraction (GO:0014848)2.53903766
115positive regulation of action potential (GO:0045760)2.52781604
116amino-acid betaine transport (GO:0015838)2.51797678
117carnitine transport (GO:0015879)2.51797678
118mitochondrion degradation (GO:0000422)2.51338667
119single strand break repair (GO:0000012)2.49282648
120regulation of action potential (GO:0098900)2.48349619
121retinal cone cell development (GO:0046549)2.47771873
122microtubule bundle formation (GO:0001578)2.47319505
123cellular response to pH (GO:0071467)2.46283879
124negative regulation of organelle assembly (GO:1902116)2.44853703
125neurofilament cytoskeleton organization (GO:0060052)2.44706005
126cellular biogenic amine biosynthetic process (GO:0042401)2.40822915
127primary amino compound metabolic process (GO:1901160)2.40281249
128left/right axis specification (GO:0070986)2.39028123
129detection of light stimulus involved in sensory perception (GO:0050962)2.38351553
130detection of light stimulus involved in visual perception (GO:0050908)2.38351553
131mitochondrial fission (GO:0000266)2.38282205
132meiotic cell cycle (GO:0051321)2.36862785
133carnitine transmembrane transport (GO:1902603)2.35353602
134protein depolymerization (GO:0051261)2.35060535
135synapsis (GO:0007129)2.29787258
136RNA destabilization (GO:0050779)2.27434545
137positive regulation of glycolytic process (GO:0045821)2.24696816
138regulation of cilium assembly (GO:1902017)2.23035172
139monoubiquitinated protein deubiquitination (GO:0035520)2.18859073
140sperm motility (GO:0030317)12.3747504
141fusion of sperm to egg plasma membrane (GO:0007342)11.8900740
142acrosome reaction (GO:0007340)11.1323378
143cell wall macromolecule catabolic process (GO:0016998)10.5303141
144cell wall macromolecule metabolic process (GO:0044036)10.5303141

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.61443052
2EZH2_22144423_ChIP-Seq_EOC_Human4.93115585
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.33955817
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.75877281
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.73893888
6VDR_22108803_ChIP-Seq_LS180_Human2.68424514
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.64102416
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.51658937
9* TAF15_26573619_Chip-Seq_HEK293_Human2.20789185
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.04817389
11EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.01621589
12GBX2_23144817_ChIP-Seq_PC3_Human2.01214758
13FLI1_27457419_Chip-Seq_LIVER_Mouse1.97094565
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94064088
15CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92218096
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.90676160
17REST_21632747_ChIP-Seq_MESCs_Mouse1.86439408
18SALL1_21062744_ChIP-ChIP_HESCs_Human1.86030415
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.85520194
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84776398
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77018040
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75991824
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.68951435
24ZNF274_21170338_ChIP-Seq_K562_Hela1.65711220
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65596093
26GATA1_26923725_Chip-Seq_HPCs_Mouse1.64664181
27* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.60111430
28ERA_21632823_ChIP-Seq_H3396_Human1.59673817
29* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.58827088
30* NANOG_20526341_ChIP-Seq_ESCs_Human1.55194582
31* KDM2B_26808549_Chip-Seq_REH_Human1.54454160
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53226725
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.51867160
34TAL1_26923725_Chip-Seq_HPCs_Mouse1.51675655
35TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.50329815
36* AR_25329375_ChIP-Seq_VCAP_Human1.50094401
37TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.49439899
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47126098
39IRF1_19129219_ChIP-ChIP_H3396_Human1.46165000
40TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42889763
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42633952
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42230948
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41859031
44AUTS2_25519132_ChIP-Seq_293T-REX_Human1.41816418
45TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41332376
46GATA3_21878914_ChIP-Seq_MCF-7_Human1.41233811
47RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.40609225
48RNF2_27304074_Chip-Seq_NSC_Mouse1.39726241
49MYC_19829295_ChIP-Seq_ESCs_Human1.38701742
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38610631
51TP53_22573176_ChIP-Seq_HFKS_Human1.38453327
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.38350334
53CBP_20019798_ChIP-Seq_JUKART_Human1.38021918
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38021918
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.37210693
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36649155
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36216533
58STAT1_17558387_ChIP-Seq_HELA_Human1.33368406
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32928097
60IGF1R_20145208_ChIP-Seq_DFB_Human1.32534950
61SMAD4_21799915_ChIP-Seq_A2780_Human1.32063022
62NCOR_22424771_ChIP-Seq_293T_Human1.31438038
63RAC3_21632823_ChIP-Seq_H3396_Human1.31217425
64EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.31161389
65TAF2_19829295_ChIP-Seq_ESCs_Human1.30262231
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28463185
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28436240
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28436240
69GABP_17652178_ChIP-ChIP_JURKAT_Human1.28308221
70NANOG_19829295_ChIP-Seq_ESCs_Human1.28256463
71SOX2_19829295_ChIP-Seq_ESCs_Human1.28256463
72STAT3_23295773_ChIP-Seq_U87_Human1.28207023
73SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.26777724
74P53_22387025_ChIP-Seq_ESCs_Mouse1.26353377
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26162133
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25345419
77* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24859379
78* FOXA1_25329375_ChIP-Seq_VCAP_Human1.24859379
79ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24843931
80EWS_26573619_Chip-Seq_HEK293_Human1.24664823
81FUS_26573619_Chip-Seq_HEK293_Human1.24356890
82RUNX2_22187159_ChIP-Seq_PCA_Human1.23633020
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23220947
84RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.22457941
85MYC_18940864_ChIP-ChIP_HL60_Human1.22357999
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.22000870
87CMYC_18555785_Chip-Seq_ESCs_Mouse1.21658011
88OCT4_20526341_ChIP-Seq_ESCs_Human1.21574246
89P300_19829295_ChIP-Seq_ESCs_Human1.21500708
90GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.21373370
91TDRD3_21172665_ChIP-Seq_MCF-7_Human1.20340707
92ELK4_26923725_Chip-Seq_MESODERM_Mouse1.19028951
93HOXB7_26014856_ChIP-Seq_BT474_Human1.17853822
94EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.17564285
95VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17223866
96ER_23166858_ChIP-Seq_MCF-7_Human1.16007938
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15093531
98* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14666185
99EZH2_27294783_Chip-Seq_ESCs_Mouse1.14047851
100SMAD3_21741376_ChIP-Seq_ESCs_Human1.14021246
101SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13221685
102PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13034285
103CRX_20693478_ChIP-Seq_RETINA_Mouse1.12907339
104P300_18555785_Chip-Seq_ESCs_Mouse1.12794284
105POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12692468
106ERG_20517297_ChIP-Seq_VCAP_Human1.10759222
107OCT4_18555785_Chip-Seq_ESCs_Mouse1.10102628
108EZH2_27304074_Chip-Seq_ESCs_Mouse1.09911329
109FOXH1_21741376_ChIP-Seq_EPCs_Human1.09693499
110RBPJ_21746931_ChIP-Seq_IB4_Human1.08962403
111EZH2_27294783_Chip-Seq_NPCs_Mouse1.08882588
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08761086
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08494396
114GATA3_21867929_ChIP-Seq_TH1_Mouse1.08307544
115WDR5_24793694_ChIP-Seq_LNCAP_Human1.08257453
116CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08172166
117STAT3_18555785_Chip-Seq_ESCs_Mouse1.08080667
118SMAD3_21741376_ChIP-Seq_EPCs_Human1.08027943
119SOX2_18555785_Chip-Seq_ESCs_Mouse1.07526958
120FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07128968
121ETV1_20927104_ChIP-Seq_GIST48_Human1.06594546
122SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06279591
123GF1_26923725_Chip-Seq_HPCs_Mouse1.06226892
124CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05981348
125TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05273406
126REST_18959480_ChIP-ChIP_MESCs_Mouse1.05267181
127TCF4_23295773_ChIP-Seq_U87_Human1.03804833
128SMAD4_21741376_ChIP-Seq_EPCs_Human1.03723426
129KLF4_18555785_Chip-Seq_ESCs_Mouse1.03722777
130KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.03292429
131E2F1_18555785_Chip-Seq_ESCs_Mouse1.03268836
132CTCF_20526341_ChIP-Seq_ESCs_Human1.02673264
133AR_20517297_ChIP-Seq_VCAP_Human1.02453356
134SOX2_22085726_ChIP-Seq_NPCs_Mouse1.02336401
135TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02273312
136ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01927894
137RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01713519
138OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01536195
139* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01425220
140AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00082247
141TCF4_22108803_ChIP-Seq_LS180_Human1.00005152
142KAP1_22055183_ChIP-Seq_ESCs_Mouse0.99713028
143YY1_22570637_ChIP-Seq_MALME-3M_Human0.99387460
144ESRRB_18555785_Chip-Seq_ESCs_Mouse0.98873621
145RUNX1_27457419_Chip-Seq_LIVER_Mouse0.98703595
146PHF8_20622853_ChIP-Seq_HELA_Human0.98702521
147PRDM14_20953172_ChIP-Seq_ESCs_Human0.98547580
148PU1_27457419_Chip-Seq_LIVER_Mouse0.98545507
149EED_16625203_ChIP-ChIP_MESCs_Mouse0.98525614
150DROSHA_22980978_ChIP-Seq_HELA_Human0.97944060
151LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.97390366
152FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96562998
153* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96390245
154SOX9_26525672_Chip-Seq_HEART_Mouse0.96313544
155MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96264195
156P53_21459846_ChIP-Seq_SAOS-2_Human0.95798247
157NMYC_18555785_Chip-Seq_ESCs_Mouse0.94565559
158CTCF_18555785_Chip-Seq_ESCs_Mouse0.94152977
159GATA3_21867929_ChIP-Seq_CD8_Mouse0.93157148
160CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92281460

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.87562929
2MP0001929_abnormal_gametogenesis4.13557733
3MP0003880_abnormal_central_pattern3.23663477
4MP0008877_abnormal_DNA_methylation3.08743944
5MP0003718_maternal_effect3.06912082
6MP0002161_abnormal_fertility/fecundity2.67727378
7MP0006292_abnormal_olfactory_placode2.49082317
8MP0002210_abnormal_sex_determination2.46462928
9MP0009046_muscle_twitch2.45095852
10MP0003878_abnormal_ear_physiology2.41546251
11MP0005377_hearing/vestibular/ear_phenot2.41546251
12MP0004859_abnormal_synaptic_plasticity2.38405134
13MP0002653_abnormal_ependyma_morphology2.27958074
14MP0001984_abnormal_olfaction2.15743879
15MP0001145_abnormal_male_reproductive2.03321710
16MP0005410_abnormal_fertilization13.0668297
17MP0004270_analgesia1.98886923
18MP0003635_abnormal_synaptic_transmissio1.97275579
19MP0001968_abnormal_touch/_nociception1.95705422
20MP0000653_abnormal_sex_gland1.79848148
21MP0009745_abnormal_behavioral_response1.78851226
22MP0002234_abnormal_pharynx_morphology1.74200175
23MP0005670_abnormal_white_adipose1.74182701
24MP0008875_abnormal_xenobiotic_pharmacok1.73118333
25MP0002736_abnormal_nociception_after1.72558578
26MP0002064_seizures1.71330508
27MP0008789_abnormal_olfactory_epithelium1.71070787
28MP0005423_abnormal_somatic_nervous1.70808509
29MP0002272_abnormal_nervous_system1.68611706
30MP0006072_abnormal_retinal_apoptosis1.68008475
31MP0002063_abnormal_learning/memory/cond1.58560734
32MP0002572_abnormal_emotion/affect_behav1.53133915
33MP0003329_amyloid_beta_deposits1.50257605
34MP0003136_yellow_coat_color1.45909099
35MP0001485_abnormal_pinna_reflex1.44510747
36MP0004133_heterotaxia1.42688756
37MP0001440_abnormal_grooming_behavior1.40881282
38MP0005645_abnormal_hypothalamus_physiol1.39737601
39MP0001486_abnormal_startle_reflex1.39309647
40MP0005623_abnormal_meninges_morphology1.35609980
41MP0003119_abnormal_digestive_system1.32791640
42MP0000049_abnormal_middle_ear1.32639181
43MP0002734_abnormal_mechanical_nocicepti1.31746686
44MP0002160_abnormal_reproductive_system1.30622153
45MP0000678_abnormal_parathyroid_gland1.28579960
46MP0008058_abnormal_DNA_repair1.26166187
47MP0005395_other_phenotype1.22338108
48MP0002067_abnormal_sensory_capabilities1.19912907
49MP0003283_abnormal_digestive_organ1.19004356
50MP0000631_abnormal_neuroendocrine_gland1.17166299
51MP0000920_abnormal_myelination1.15793435
52MP0002139_abnormal_hepatobiliary_system1.13475136
53MP0003879_abnormal_hair_cell1.13131260
54MP0005379_endocrine/exocrine_gland_phen1.09642877
55MP0001348_abnormal_lacrimal_gland1.08148179
56MP0002735_abnormal_chemical_nociception1.06777400
57MP0001529_abnormal_vocalization1.06552181
58MP0005551_abnormal_eye_electrophysiolog1.06231600
59MP0004742_abnormal_vestibular_system1.05841479
60MP0003646_muscle_fatigue1.04618739
61MP0001765_abnormal_ion_homeostasis1.02107005
62MP0000026_abnormal_inner_ear0.99708394
63MP0001293_anophthalmia0.99014683
64MP0005365_abnormal_bile_salt0.98330309
65MP0005360_urolithiasis0.97532761
66MP0002938_white_spotting0.96899928
67MP0008569_lethality_at_weaning0.96748185
68MP0001905_abnormal_dopamine_level0.94638894
69MP0003787_abnormal_imprinting0.94570668
70MP0003693_abnormal_embryo_hatching0.94377479
71MP0003121_genomic_imprinting0.93472512
72MP0003890_abnormal_embryonic-extraembry0.92832840
73MP0000372_irregular_coat_pigmentation0.92463137
74MP0003937_abnormal_limbs/digits/tail_de0.92156053
75MP0001501_abnormal_sleep_pattern0.90557199
76MP0005535_abnormal_body_temperature0.89494630
77MP0000427_abnormal_hair_cycle0.88783821
78MP0002638_abnormal_pupillary_reflex0.88547356
79MP0002254_reproductive_system_inflammat0.88056578
80MP0002557_abnormal_social/conspecific_i0.87389810
81MP0001970_abnormal_pain_threshold0.86345448
82MP0003633_abnormal_nervous_system0.85931332
83MP0004811_abnormal_neuron_physiology0.84638305
84MP0000778_abnormal_nervous_system0.82025944
85MP0005174_abnormal_tail_pigmentation0.80919840
86MP0005647_abnormal_sex_gland0.80752497
87MP0002229_neurodegeneration0.80439356
88MP0002138_abnormal_hepatobiliary_system0.79534115
89MP0004142_abnormal_muscle_tone0.79217818
90MP0008995_early_reproductive_senescence0.79116292
91MP0000604_amyloidosis0.78808653
92MP0003631_nervous_system_phenotype0.78467201
93MP0005636_abnormal_mineral_homeostasis0.77991754
94MP0005195_abnormal_posterior_eye0.77930872
95MP0001986_abnormal_taste_sensitivity0.77242745
96MP0003137_abnormal_impulse_conducting0.77172722
97MP0004233_abnormal_muscle_weight0.76699980
98MP0002282_abnormal_trachea_morphology0.76586539
99MP0005391_vision/eye_phenotype0.75364880
100MP0002882_abnormal_neuron_morphology0.75332621
101MP0002066_abnormal_motor_capabilities/c0.75020024
102MP0001119_abnormal_female_reproductive0.75007568
103MP0003699_abnormal_female_reproductive0.74622028
104MP0001502_abnormal_circadian_rhythm0.73906273
105MP0005085_abnormal_gallbladder_physiolo0.73655077
106MP0004885_abnormal_endolymph0.70543514
107MP0004924_abnormal_behavior0.69511416
108MP0005386_behavior/neurological_phenoty0.69511416
109MP0006276_abnormal_autonomic_nervous0.68923527
110MP0008872_abnormal_physiological_respon0.67822991
111MP0005646_abnormal_pituitary_gland0.65768739
112MP0003690_abnormal_glial_cell0.65753555
113MP0001963_abnormal_hearing_physiology0.65183496
114MP0002733_abnormal_thermal_nociception0.64966469
115MP0000955_abnormal_spinal_cord0.64675779
116MP0002837_dystrophic_cardiac_calcinosis0.64231825
117MP0002152_abnormal_brain_morphology0.63915445
118MP0002876_abnormal_thyroid_physiology0.59711083
119MP0009697_abnormal_copulation0.57005441
120MP0002102_abnormal_ear_morphology0.56736454
121MP0001324_abnormal_eye_pigmentation0.53866620
122MP0003632_abnormal_nervous_system0.53025886
123MP0002184_abnormal_innervation0.51907002
124MP0003634_abnormal_glial_cell0.51508597
125MP0002752_abnormal_somatic_nervous0.50420552
126MP0005389_reproductive_system_phenotype0.50314346
127MP0003011_delayed_dark_adaptation0.50195141
128MP0004036_abnormal_muscle_relaxation0.49662693
129MP0005499_abnormal_olfactory_system0.49381954
130MP0005394_taste/olfaction_phenotype0.49381954
131MP0010329_abnormal_lipoprotein_level0.48939293
132MP0001764_abnormal_homeostasis0.47158962
133MP0002118_abnormal_lipid_homeostasis0.45383730
134MP0003656_abnormal_erythrocyte_physiolo0.45075124
135MP0002971_abnormal_brown_adipose0.44160874
136MP0005083_abnormal_biliary_tract0.42737181
137MP0008961_abnormal_basal_metabolism0.42476092
138MP0003195_calcinosis0.41336332
139MP0005253_abnormal_eye_physiology0.39932334

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.14633534
2Abnormal respiratory epithelium morphology (HP:0012253)7.83394386
3Abnormal respiratory motile cilium morphology (HP:0005938)7.83394386
4Abnormal ciliary motility (HP:0012262)6.52717763
5Rhinitis (HP:0012384)6.49328066
6Chronic bronchitis (HP:0004469)5.94607602
7Infertility (HP:0000789)5.87825067
8Abnormal gallbladder physiology (HP:0012438)5.23270552
9Cholecystitis (HP:0001082)5.23270552
10Nasal polyposis (HP:0100582)4.85982606
11Peripheral hypomyelination (HP:0007182)3.89694099
12Severe visual impairment (HP:0001141)3.85778115
13Abnormality of the nasal mucosa (HP:0000433)3.83102924
14Male infertility (HP:0003251)3.70601322
15Nephronophthisis (HP:0000090)3.69547882
16Chronic hepatic failure (HP:0100626)3.67449928
17Attenuation of retinal blood vessels (HP:0007843)3.58889320
18Bronchiectasis (HP:0002110)3.54081191
19Pancreatic cysts (HP:0001737)3.45028030
20Bronchitis (HP:0012387)3.43952897
21Bony spicule pigmentary retinopathy (HP:0007737)3.34285788
22Abnormal rod and cone electroretinograms (HP:0008323)3.23031797
23True hermaphroditism (HP:0010459)2.91664006
24Medial flaring of the eyebrow (HP:0010747)2.87040079
25Abnormal spermatogenesis (HP:0008669)2.83085478
26Abnormality of the renal medulla (HP:0100957)2.77849568
27Recurrent sinusitis (HP:0011108)2.69033913
28Recurrent otitis media (HP:0000403)2.67142054
29Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.65383684
30Cerebellar dysplasia (HP:0007033)2.63659234
31Tubular atrophy (HP:0000092)2.62600069
32Abnormality of macular pigmentation (HP:0008002)2.57957013
33Polyuria (HP:0000103)2.57462054
34Pendular nystagmus (HP:0012043)2.48805460
35Molar tooth sign on MRI (HP:0002419)2.47644076
36Abnormality of midbrain morphology (HP:0002418)2.47644076
37Congenital stationary night blindness (HP:0007642)2.44804013
38Hyperventilation (HP:0002883)2.44771703
39Neurofibrillary tangles (HP:0002185)2.42101281
40Abnormal urine output (HP:0012590)2.38878099
41Tubulointerstitial nephritis (HP:0001970)2.35198062
42Cystic liver disease (HP:0006706)2.32886116
43Tubulointerstitial abnormality (HP:0001969)2.32350567
44Spastic tetraparesis (HP:0001285)2.27111196
45Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.23490387
46Degeneration of the lateral corticospinal tracts (HP:0002314)2.23490387
47Occipital encephalocele (HP:0002085)2.21978080
48Absent eyebrow (HP:0002223)2.20863552
49Anencephaly (HP:0002323)2.20235800
50Focal motor seizures (HP:0011153)2.19462820
51Sclerocornea (HP:0000647)2.18879312
52Tubulointerstitial fibrosis (HP:0005576)2.17436332
53Epileptic encephalopathy (HP:0200134)2.15868385
54Genital tract atresia (HP:0001827)2.15110916
55Vaginal atresia (HP:0000148)2.14592046
56Abnormality of renal excretion (HP:0011036)2.14230910
57Choroideremia (HP:0001139)2.09353946
58Abnormality of the aortic arch (HP:0012303)2.07101701
59Renal Fanconi syndrome (HP:0001994)2.06563202
60Optic nerve hypoplasia (HP:0000609)2.04822663
61Cerebral inclusion bodies (HP:0100314)2.03747129
62Hyperkalemia (HP:0002153)2.03744928
63Decreased central vision (HP:0007663)2.03402701
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.00283685
65Dynein arm defect of respiratory motile cilia (HP:0012255)11.6539205
66Absent/shortened dynein arms (HP:0200106)11.6539205
67Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.6023907
68Impulsivity (HP:0100710)1.99450896
69Supernumerary spleens (HP:0009799)1.99067778
70Abolished electroretinogram (ERG) (HP:0000550)1.98914444
71Gait imbalance (HP:0002141)1.98345898
72Anterior segment dysgenesis (HP:0007700)1.96305849
73Enlarged epiphyses (HP:0010580)1.95641517
74Dyschromatopsia (HP:0007641)1.95004467
75Gonadotropin excess (HP:0000837)1.92667240
76Azoospermia (HP:0000027)1.91461579
77Sensory axonal neuropathy (HP:0003390)1.90979572
78Cone-rod dystrophy (HP:0000548)1.88556535
79Retinal dysplasia (HP:0007973)1.87994027
80Abnormality of the corticospinal tract (HP:0002492)1.87683876
81Congenital primary aphakia (HP:0007707)1.86674681
82Abnormality of the labia minora (HP:0012880)1.85997387
83Aplasia/Hypoplasia of the tongue (HP:0010295)1.85366342
84Abnormality of abdominal situs (HP:0011620)1.82843489
85Abdominal situs inversus (HP:0003363)1.82843489
86Aplasia/Hypoplasia of the uvula (HP:0010293)1.82758608
87Facial shape deformation (HP:0011334)1.82730500
88Potter facies (HP:0002009)1.82730500
89Male pseudohermaphroditism (HP:0000037)1.82504537
90Progressive cerebellar ataxia (HP:0002073)1.79683169
91Bilateral microphthalmos (HP:0007633)1.77932748
92Recurrent bronchitis (HP:0002837)1.76849761
93Renal dysplasia (HP:0000110)1.76350598
94Aplasia/Hypoplasia of the tibia (HP:0005772)1.75181676
95Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74448292
96Abnormality of the ileum (HP:0001549)1.74208624
97Gastrointestinal atresia (HP:0002589)1.73217851
98Bifid tongue (HP:0010297)1.72585828
99Intestinal atresia (HP:0011100)1.72067580
100Facial cleft (HP:0002006)1.72034736
101Gaze-evoked nystagmus (HP:0000640)1.71037540
102Absent rod-and cone-mediated responses on ERG (HP:0007688)1.70935408
103Hypophosphatemic rickets (HP:0004912)1.70740901
104Hemiparesis (HP:0001269)1.70440926
105Generalized aminoaciduria (HP:0002909)1.69850509
106Small intestinal stenosis (HP:0012848)1.68725663
107Duodenal stenosis (HP:0100867)1.68725663
108Abnormality of alanine metabolism (HP:0010916)1.68606293
109Hyperalaninemia (HP:0003348)1.68606293
110Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68606293
111Decreased motor nerve conduction velocity (HP:0003431)1.68458480
112Chorioretinal atrophy (HP:0000533)1.68043873
113Decreased circulating renin level (HP:0003351)1.67537053
114Aplasia/hypoplasia of the uterus (HP:0008684)1.67189605
115Glycosuria (HP:0003076)1.67043494
116Abnormality of urine glucose concentration (HP:0011016)1.67043494
117Atonic seizures (HP:0010819)1.66963832
118Hyperglycinemia (HP:0002154)1.65657659
119Cholelithiasis (HP:0001081)1.63680922
120Short tibia (HP:0005736)1.63501270
121Bile duct proliferation (HP:0001408)1.62995714
122Abnormal biliary tract physiology (HP:0012439)1.62995714
123Aplasia/Hypoplasia of the lens (HP:0008063)1.62802596
124Poor coordination (HP:0002370)1.62699336
125Postaxial foot polydactyly (HP:0001830)1.58051257
126Type II lissencephaly (HP:0007260)1.57658436
127Postaxial hand polydactyly (HP:0001162)1.57438052
128Nephrogenic diabetes insipidus (HP:0009806)1.56821589
129Abnormal gallbladder morphology (HP:0012437)1.50867491
130Focal seizures (HP:0007359)1.49984969
131Abnormality of the lower motor neuron (HP:0002366)1.46282278
132Abnormal drinking behavior (HP:0030082)1.45931527
133Polydipsia (HP:0001959)1.45931527
134Neuronal loss in central nervous system (HP:0002529)1.44978593
135Supranuclear gaze palsy (HP:0000605)1.44496720
136Clumsiness (HP:0002312)1.44335623
137Congenital hepatic fibrosis (HP:0002612)1.43807990
138Inability to walk (HP:0002540)1.43344075
139Decreased muscle mass (HP:0003199)1.42164683
140Myokymia (HP:0002411)1.41482195
141Stage 5 chronic kidney disease (HP:0003774)1.39443896
142Abnormality of saccadic eye movements (HP:0000570)1.36794719
143Abnormality of the renal cortex (HP:0011035)1.36585728
144Hypoplasia of the brainstem (HP:0002365)1.35708682
145Aplasia/Hypoplasia of the brainstem (HP:0007362)1.35708682
146Progressive inability to walk (HP:0002505)1.34886185
147Myelomeningocele (HP:0002475)1.34756177
148Hemorrhage of the eye (HP:0011885)1.34577480
149Pachygyria (HP:0001302)1.34025446
150Abnormality of the gallbladder (HP:0005264)1.32897560
151Oculomotor apraxia (HP:0000657)1.32774079
152Broad-based gait (HP:0002136)1.32449564
153Abnormality of permanent molar morphology (HP:0011071)1.31926193
154Abnormality of the dental root (HP:0006486)1.31926193
155Taurodontia (HP:0000679)1.31926193
156Reticulocytosis (HP:0001923)1.31646688
157Pancreatic fibrosis (HP:0100732)1.29968226

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.85252601
2PDK36.85252601
3TESK15.28243604
4PLK45.16911204
5PDK24.36271119
6PRKD34.14034133
7PTK2B3.48588148
8ICK3.46122444
9MAP4K23.42494087
10PNCK2.94087611
11STK392.88935016
12FRK2.49606453
13ZAK2.48807727
14INSRR2.34662931
15WNK42.17938680
16WNK32.17583829
17ACVR1B2.14085632
18CASK2.10286546
19RIPK41.92083625
20MAP3K41.79971638
21GRK11.74919156
22MAP2K71.69853680
23NUAK11.59331394
24BUB11.51201763
25STK38L1.48731632
26EPHA41.39833089
27DYRK21.35241617
28STK381.31542824
29MAPK151.26536438
30TRIM281.24698803
31DYRK1B1.23407748
32DAPK21.18679272
33BRSK21.15326919
34CCNB11.13447240
35ADRBK21.13429185
36BRD41.12716549
37TESK21.12547425
38OXSR11.06721559
39DDR21.05662536
40PLK11.03733971
41MAP2K41.00897313
42PDK11.00681983
43WNK11.00235441
44BRSK10.89846985
45TTK0.88480815
46VRK10.87492055
47PLK20.86601690
48NTRK30.85862813
49PRKCI0.82117135
50TLK10.81760409
51SRPK10.78349993
52PINK10.76983374
53TGFBR10.76131676
54MARK10.73695490
55PRKCG0.71468661
56TYRO30.70499622
57TIE10.70442040
58AURKA0.70195403
59PLK30.69838409
60NME10.67869119
61PAK60.66804936
62CSNK1G20.66589380
63STK160.66540774
64CAMK2A0.66424096
65CSNK1G10.65556008
66PHKG10.64531992
67PHKG20.64531992
68PDPK10.64137373
69TXK0.63721264
70NTRK20.63716352
71ADRBK10.63715987
72MARK30.63525929
73CDK190.63345673
74MET0.63092101
75ARAF0.62561846
76PKN10.62264400
77CAMK1D0.61088950
78MKNK20.59731556
79BMPR20.58785217
80MINK10.58670305
81MAPKAPK50.57714839
82TNIK0.57412840
83CDK70.56975474
84CDC70.56888748
85CSNK1G30.56207704
86MUSK0.56038946
87MAP3K120.55146224
88PBK0.53716014
89GRK50.53106079
90CDK50.51977142
91TAOK30.51453317
92BMPR1B0.50180320
93VRK20.48985035
94CAMK2B0.47446989
95DAPK10.46204665
96SGK2230.46140998
97SGK4940.46140998
98CHEK10.45621803
99MAP3K90.44549778
100AKT30.42837875
101CDK80.42836989
102NEK20.41734420
103WEE10.40838853
104CAMK1G0.40754295
105MAP2K60.39401910
106PRKCH0.39281994
107ATM0.38712483
108CDK140.38415283
109MAPK130.38298941
110CDK10.37343811
111CAMKK10.37290569
112CDK150.36508427
113CDK180.36440448
114MAP2K20.36042089
115BCR0.34423044
116SIK20.34063169
117CDK20.33948366
118PRKCQ0.32891188
119IRAK10.32724973
120GRK70.32612614
121KSR20.30986871
122CDK30.29523559
123MARK20.29385971
124NEK60.28409955
125PRKCZ0.28397633
126STK110.27733908
127BRAF0.27304118
128CDK11A0.27165491
129FGR0.24904677
130PRKG10.24468075
131FES0.24197224
132CAMK2D0.23880045
133BLK0.23875358
134MAP3K10.23565172
135UHMK10.23074910
136CAMK2G0.22718118
137NTRK10.22005559
138MAP3K20.21692317
139SGK20.19584140
140DAPK30.19271560
141PAK10.17967168
142CHEK20.17640986
143PRKCA0.15520229
144SGK10.15406576
145DYRK1A0.15098194
146PRKACA0.14178915
147PRKCD0.13837998
148PAK30.13746062
149DYRK30.12863027
150CAMK10.12414117
151CAMKK20.12223492
152TNK20.11895517
153PRKCB0.11691290
154PRKCE0.10463549

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005245.46477538
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.92821248
3Fatty acid biosynthesis_Homo sapiens_hsa000612.58617515
4Pyruvate metabolism_Homo sapiens_hsa006202.52205839
5Collecting duct acid secretion_Homo sapiens_hsa049662.49574724
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.46829289
7Synaptic vesicle cycle_Homo sapiens_hsa047212.24852167
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.12039890
9Butanoate metabolism_Homo sapiens_hsa006502.06055073
10RNA polymerase_Homo sapiens_hsa030202.05253899
11Propanoate metabolism_Homo sapiens_hsa006401.99459196
12Carbohydrate digestion and absorption_Homo sapiens_hsa049731.98241903
13Amphetamine addiction_Homo sapiens_hsa050311.96594062
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.93703446
15Vitamin B6 metabolism_Homo sapiens_hsa007501.89714883
16Nicotine addiction_Homo sapiens_hsa050331.89192602
17Fanconi anemia pathway_Homo sapiens_hsa034601.71934964
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.70679120
19Cardiac muscle contraction_Homo sapiens_hsa042601.63395703
20Linoleic acid metabolism_Homo sapiens_hsa005911.63150472
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.61086703
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.60832205
23RNA transport_Homo sapiens_hsa030131.60262757
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57177464
25Homologous recombination_Homo sapiens_hsa034401.56442191
26Long-term potentiation_Homo sapiens_hsa047201.56279287
27RNA degradation_Homo sapiens_hsa030181.55809445
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.53757793
29Glucagon signaling pathway_Homo sapiens_hsa049221.47972333
30Sulfur metabolism_Homo sapiens_hsa009201.46171797
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46076092
32Taste transduction_Homo sapiens_hsa047421.45682112
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.44761495
34Huntingtons disease_Homo sapiens_hsa050161.43461598
35Dorso-ventral axis formation_Homo sapiens_hsa043201.42944739
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.42154322
37Oxidative phosphorylation_Homo sapiens_hsa001901.40712145
38Glycerolipid metabolism_Homo sapiens_hsa005611.37990034
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.35884020
40Renin secretion_Homo sapiens_hsa049241.33163983
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31391537
42Nitrogen metabolism_Homo sapiens_hsa009101.31034080
43Circadian entrainment_Homo sapiens_hsa047131.30311133
44Salivary secretion_Homo sapiens_hsa049701.29504777
45Olfactory transduction_Homo sapiens_hsa047401.25693037
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21268307
47Insulin secretion_Homo sapiens_hsa049111.20991673
48Fructose and mannose metabolism_Homo sapiens_hsa000511.19954067
49Glutamatergic synapse_Homo sapiens_hsa047241.19158045
50PPAR signaling pathway_Homo sapiens_hsa033201.18598334
51Chemical carcinogenesis_Homo sapiens_hsa052041.16731900
52Mineral absorption_Homo sapiens_hsa049781.15627120
53Purine metabolism_Homo sapiens_hsa002301.14562170
54Ribosome_Homo sapiens_hsa030101.09438380
55Ether lipid metabolism_Homo sapiens_hsa005651.08493063
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.08090500
57Regulation of autophagy_Homo sapiens_hsa041401.07923235
58Glycerophospholipid metabolism_Homo sapiens_hsa005641.06100698
59Protein export_Homo sapiens_hsa030601.05753819
60Mismatch repair_Homo sapiens_hsa034301.04770122
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02516569
62Bile secretion_Homo sapiens_hsa049761.01944928
63Caffeine metabolism_Homo sapiens_hsa002321.01526248
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99738132
65Alzheimers disease_Homo sapiens_hsa050100.98913617
66Nucleotide excision repair_Homo sapiens_hsa034200.97048743
67Calcium signaling pathway_Homo sapiens_hsa040200.95429326
68Retinol metabolism_Homo sapiens_hsa008300.94855516
69Pyrimidine metabolism_Homo sapiens_hsa002400.94368496
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93943638
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.90549777
72Base excision repair_Homo sapiens_hsa034100.88255174
73One carbon pool by folate_Homo sapiens_hsa006700.87650580
74Basal transcription factors_Homo sapiens_hsa030220.86893001
75Carbon metabolism_Homo sapiens_hsa012000.86286617
76beta-Alanine metabolism_Homo sapiens_hsa004100.85474694
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84353675
78Gastric acid secretion_Homo sapiens_hsa049710.83921718
79Morphine addiction_Homo sapiens_hsa050320.83583186
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83581002
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82149374
82Parkinsons disease_Homo sapiens_hsa050120.81171369
83Fatty acid metabolism_Homo sapiens_hsa012120.80381833
84Oocyte meiosis_Homo sapiens_hsa041140.80002386
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77290330
86Arginine and proline metabolism_Homo sapiens_hsa003300.76970734
87Metabolic pathways_Homo sapiens_hsa011000.76477589
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.75825210
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75502218
90Tryptophan metabolism_Homo sapiens_hsa003800.75024710
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74968672
92Non-homologous end-joining_Homo sapiens_hsa034500.74376423
93Dopaminergic synapse_Homo sapiens_hsa047280.73221291
94Cocaine addiction_Homo sapiens_hsa050300.72877049
95Tyrosine metabolism_Homo sapiens_hsa003500.72088852
96Vibrio cholerae infection_Homo sapiens_hsa051100.71944000
97Steroid biosynthesis_Homo sapiens_hsa001000.70824841
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70717329
99Fatty acid degradation_Homo sapiens_hsa000710.68928126
100Hedgehog signaling pathway_Homo sapiens_hsa043400.68041920
101GABAergic synapse_Homo sapiens_hsa047270.67269256
102Rheumatoid arthritis_Homo sapiens_hsa053230.66382436
103Type II diabetes mellitus_Homo sapiens_hsa049300.64772173
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62212513
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62133100
106ABC transporters_Homo sapiens_hsa020100.62086356
107Fat digestion and absorption_Homo sapiens_hsa049750.62027961
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.61118166
109Proteasome_Homo sapiens_hsa030500.60341355
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60131016
111Folate biosynthesis_Homo sapiens_hsa007900.58657341
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57661093
113Pentose phosphate pathway_Homo sapiens_hsa000300.56664485
114Histidine metabolism_Homo sapiens_hsa003400.56194103
115Phototransduction_Homo sapiens_hsa047440.55134149
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54932854
117Pancreatic secretion_Homo sapiens_hsa049720.54283173
118Selenocompound metabolism_Homo sapiens_hsa004500.54119224
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54067542
120Estrogen signaling pathway_Homo sapiens_hsa049150.53139218
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53081840
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51296462
123Thyroid hormone synthesis_Homo sapiens_hsa049180.50640040
124Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50458978
125Sulfur relay system_Homo sapiens_hsa041220.50263087
126DNA replication_Homo sapiens_hsa030300.48882703
127Cell cycle_Homo sapiens_hsa041100.48208867
128Circadian rhythm_Homo sapiens_hsa047100.48162867
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48055830
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47583385
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.47131751
132Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47064115
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47058764
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46840703
135Fatty acid elongation_Homo sapiens_hsa000620.46661470
136p53 signaling pathway_Homo sapiens_hsa041150.46649270
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46451166
138cAMP signaling pathway_Homo sapiens_hsa040240.45536274
139Glutathione metabolism_Homo sapiens_hsa004800.44885103
140Serotonergic synapse_Homo sapiens_hsa047260.44581731
141Arachidonic acid metabolism_Homo sapiens_hsa005900.43635392
142Ovarian steroidogenesis_Homo sapiens_hsa049130.43336511
143Phenylalanine metabolism_Homo sapiens_hsa003600.42563608
144Starch and sucrose metabolism_Homo sapiens_hsa005000.42553082
145Oxytocin signaling pathway_Homo sapiens_hsa049210.42348623
146Peroxisome_Homo sapiens_hsa041460.41542477

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