CACFD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)6.26706396
2COPI coating of Golgi vesicle (GO:0048205)5.86467763
3Golgi transport vesicle coating (GO:0048200)5.86467763
4glial cell proliferation (GO:0014009)4.78796634
5pyrimidine nucleobase catabolic process (GO:0006208)4.41995917
6regulation of chromatin binding (GO:0035561)3.90281388
7dendritic spine morphogenesis (GO:0060997)3.86405823
8establishment of mitochondrion localization (GO:0051654)3.82061869
9retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.75928616
10positive regulation of mitochondrial fission (GO:0090141)3.65730673
11COPII vesicle coating (GO:0048208)3.64730007
12proximal/distal pattern formation (GO:0009954)3.62233076
13nucleobase catabolic process (GO:0046113)3.58931705
14exocrine pancreas development (GO:0031017)3.50711791
15vesicle coating (GO:0006901)3.41772809
16glandular epithelial cell development (GO:0002068)3.41345059
17hindbrain development (GO:0030902)3.41006899
18calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.39538944
19potassium ion export (GO:0071435)3.37344057
20membrane repolarization (GO:0086009)3.35055279
21vocalization behavior (GO:0071625)3.34355530
22axonemal dynein complex assembly (GO:0070286)3.31625560
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.30688457
24L-phenylalanine metabolic process (GO:0006558)3.30688457
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.27907867
26L-phenylalanine catabolic process (GO:0006559)3.27907867
27maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.26048522
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.20633124
29substrate-independent telencephalic tangential migration (GO:0021826)3.20243281
30substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.20243281
31activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.20223119
32synapse assembly (GO:0007416)3.19452877
33postsynaptic membrane organization (GO:0001941)3.16523420
34endocrine pancreas development (GO:0031018)3.12013260
35cornea development in camera-type eye (GO:0061303)3.11518471
36behavioral response to nicotine (GO:0035095)3.11279278
37dendritic spine organization (GO:0097061)3.08442285
38epithelial cell fate commitment (GO:0072148)3.07577522
39neuron recognition (GO:0008038)3.07345020
40positive regulation of nuclease activity (GO:0032075)3.01106406
41regulation of hippo signaling (GO:0035330)3.00526603
42apical protein localization (GO:0045176)2.97819964
43membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.93729351
44retinal ganglion cell axon guidance (GO:0031290)2.92733724
45protein retention in ER lumen (GO:0006621)2.92325256
46regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.89682075
47glandular epithelial cell differentiation (GO:0002067)2.85483013
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.85398309
49neuronal ion channel clustering (GO:0045161)2.84908229
50presynaptic membrane assembly (GO:0097105)2.84745313
51N-glycan processing (GO:0006491)2.83837419
52protein localization to cilium (GO:0061512)2.81068800
53epithelial cilium movement (GO:0003351)2.80234103
54regulation of NFAT protein import into nucleus (GO:0051532)2.80161547
55regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.79668431
56presynaptic membrane organization (GO:0097090)2.78868983
57type B pancreatic cell development (GO:0003323)2.78278215
58gamma-aminobutyric acid transport (GO:0015812)2.76226737
59glyoxylate metabolic process (GO:0046487)2.75720149
60regulation of mitochondrial fission (GO:0090140)2.73444470
61cilium movement (GO:0003341)2.72379350
62mitochondrion transport along microtubule (GO:0047497)2.71970197
63establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.71970197
64dorsal/ventral axis specification (GO:0009950)2.71308975
65adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.69261101
66macroautophagy (GO:0016236)2.68750860
67dopaminergic neuron differentiation (GO:0071542)2.68524219
68alpha-linolenic acid metabolic process (GO:0036109)2.66323221
69planar cell polarity pathway involved in neural tube closure (GO:0090179)2.66036032
70regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.64660981
71cellular ketone body metabolic process (GO:0046950)2.64088222
72regulation of nuclease activity (GO:0032069)2.63734321
73negative regulation of glycogen metabolic process (GO:0070874)2.63130311
74ganglion development (GO:0061548)2.62366639
75ephrin receptor signaling pathway (GO:0048013)2.61408854
76arginine metabolic process (GO:0006525)2.59586088
77negative regulation of glycogen biosynthetic process (GO:0045719)2.58059785
78convergent extension (GO:0060026)2.56971425
79tooth mineralization (GO:0034505)2.56153572
80central nervous system projection neuron axonogenesis (GO:0021952)2.55964788
81membrane repolarization during action potential (GO:0086011)2.55415051
82axon extension (GO:0048675)2.55022284
83endoplasmic reticulum unfolded protein response (GO:0030968)2.54418350
84growth hormone secretion (GO:0030252)2.53937562
85positive regulation of synapse assembly (GO:0051965)2.53588872
86neuron projection extension involved in neuron projection guidance (GO:1902284)2.53317950
87axon extension involved in axon guidance (GO:0048846)2.53317950
88glycosphingolipid biosynthetic process (GO:0006688)2.53214571
89cell-cell junction maintenance (GO:0045217)2.53060744
90regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.52785503
91negative regulation of oligodendrocyte differentiation (GO:0048715)2.49310672
92ER-nucleus signaling pathway (GO:0006984)2.48410373
93coenzyme catabolic process (GO:0009109)2.48401305
94cellular response to glucagon stimulus (GO:0071377)2.48132012
95arginine catabolic process (GO:0006527)2.47400610
96olfactory bulb development (GO:0021772)2.46770832
97phenylpropanoid metabolic process (GO:0009698)2.46487459
98lung secretory cell differentiation (GO:0061140)2.45944980
994-hydroxyproline metabolic process (GO:0019471)2.45844198
100astrocyte differentiation (GO:0048708)2.45427790
101neurotransmitter biosynthetic process (GO:0042136)2.45333320
102protein localization to synapse (GO:0035418)2.45169061
103cell junction maintenance (GO:0034331)2.44048460
104layer formation in cerebral cortex (GO:0021819)2.42042854
105epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.41531941
106transmission of nerve impulse (GO:0019226)2.41005365
107cellular response to unfolded protein (GO:0034620)2.40828999
108aromatic amino acid family catabolic process (GO:0009074)2.40520891
109ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.40107376
110epoxygenase P450 pathway (GO:0019373)2.39177534
111regulation of autophagic vacuole assembly (GO:2000785)2.39177351
112positive regulation of gastrulation (GO:2000543)2.38473785
113somite development (GO:0061053)2.38374695
114intraciliary transport (GO:0042073)2.38195140
115negative regulation of cell size (GO:0045792)2.37886131
116cell migration in hindbrain (GO:0021535)2.36556804
117positive regulation of hormone biosynthetic process (GO:0046886)2.35529495
118peroxisome fission (GO:0016559)2.34708501
119positive regulation of glycogen biosynthetic process (GO:0045725)2.30601219
120protein insertion into membrane (GO:0051205)2.30412974
121synapse organization (GO:0050808)2.30356378
122insulin secretion (GO:0030073)2.30206268
123positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.28664216
124mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.28664216
125neuron cell-cell adhesion (GO:0007158)2.28240683
126regulation of cilium movement (GO:0003352)2.27874243
127cellular response to topologically incorrect protein (GO:0035967)2.27536644
128response to dietary excess (GO:0002021)2.26813466
129axonal fasciculation (GO:0007413)2.26081851
130intracellular estrogen receptor signaling pathway (GO:0030520)2.25763826
131regulation of cholesterol homeostasis (GO:2000188)2.25700681
132cerebellar Purkinje cell layer development (GO:0021680)2.25456422
133neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.25438547
134cellular zinc ion homeostasis (GO:0006882)2.25427855
135exogenous drug catabolic process (GO:0042738)2.24991105
136intestinal cholesterol absorption (GO:0030299)2.23466003
137hippocampus development (GO:0021766)2.23398003
138glutamate secretion (GO:0014047)2.23053417
139positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.22984180
140nonmotile primary cilium assembly (GO:0035058)2.22289022
141positive regulation of synapse maturation (GO:0090129)2.20934917
142urinary tract smooth muscle contraction (GO:0014848)2.20162357
143ectoderm development (GO:0007398)2.20133156
144regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.20018970
145lysine metabolic process (GO:0006553)2.19949014
146lysine catabolic process (GO:0006554)2.19949014
147post-embryonic morphogenesis (GO:0009886)2.19651351
148cholesterol biosynthetic process (GO:0006695)2.19579001
149peptide hormone processing (GO:0016486)2.18711239
150neurotransmitter-gated ion channel clustering (GO:0072578)2.18333283
151positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.17993671
152lateral sprouting from an epithelium (GO:0060601)2.17709403
153neuronal stem cell maintenance (GO:0097150)2.17668954
154dendrite morphogenesis (GO:0048813)2.17617857
155sulfur amino acid catabolic process (GO:0000098)2.17604463
156drug metabolic process (GO:0017144)2.17562408
157insulin-like growth factor receptor signaling pathway (GO:0048009)2.17470250
158cranial nerve morphogenesis (GO:0021602)2.17114270
159short-term memory (GO:0007614)2.17096456
160regulation of microtubule-based movement (GO:0060632)2.17011831
161ER overload response (GO:0006983)2.16679156
162embryonic retina morphogenesis in camera-type eye (GO:0060059)2.16380018
163neuron projection extension (GO:1990138)2.15788157
164drug catabolic process (GO:0042737)2.15461089
165motile cilium assembly (GO:0044458)2.14725984
166negative regulation of stem cell proliferation (GO:2000647)2.14258941
167positive regulation of glycogen metabolic process (GO:0070875)2.14193995
168positive regulation of protein targeting to membrane (GO:0090314)2.13429042
169iron coordination entity transport (GO:1901678)2.13086252
170positive regulation of glycolytic process (GO:0045821)2.12252807
171cilium or flagellum-dependent cell motility (GO:0001539)2.12194860
172head development (GO:0060322)2.11783121
173asymmetric protein localization (GO:0008105)2.11725293
174establishment of melanosome localization (GO:0032401)2.11344287
175synaptic vesicle maturation (GO:0016188)2.11342567
176L-alpha-amino acid transmembrane transport (GO:1902475)2.11251885
177neurotransmitter metabolic process (GO:0042133)2.10849692
178regulation of vacuole organization (GO:0044088)2.10635608
179positive regulation of insulin secretion (GO:0032024)2.10509011
180negative regulation of axon guidance (GO:1902668)2.09172939
181auditory receptor cell differentiation (GO:0042491)2.08743896
182auditory behavior (GO:0031223)2.08531401
183ethanol metabolic process (GO:0006067)2.06076324
184camera-type eye morphogenesis (GO:0048593)2.05839484
185calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.05742783
186spinal cord association neuron differentiation (GO:0021527)2.04237738
187establishment of pigment granule localization (GO:0051905)2.04034961

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.04937498
2EZH2_22144423_ChIP-Seq_EOC_Human2.65454185
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.55519160
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47724347
5DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.30789229
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.28928419
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.24384378
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.22645619
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22544996
10TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.15653027
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.09166610
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.07254597
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.06110155
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.06110155
15EZH2_27294783_Chip-Seq_ESCs_Mouse2.04880662
16OLIG2_26023283_ChIP-Seq_AINV15_Mouse2.01726682
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00528815
18DROSHA_22980978_ChIP-Seq_HELA_Human1.95712678
19RBPJ_22232070_ChIP-Seq_NCS_Mouse1.93973176
20SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93188839
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.92896407
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91032873
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.90538090
24ERG_21242973_ChIP-ChIP_JURKAT_Human1.85897580
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.85776263
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82876196
27ZFP281_18757296_ChIP-ChIP_E14_Mouse1.81622776
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81157261
29MTF2_20144788_ChIP-Seq_MESCs_Mouse1.80995734
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80510288
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.77494944
32PPARA_22158963_ChIP-Seq_LIVER_Mouse1.76564564
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74906394
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.74771197
35LXR_22158963_ChIP-Seq_LIVER_Mouse1.73095172
36NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.69008306
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.67013821
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63945708
39KDM2B_26808549_Chip-Seq_K562_Human1.63329222
40IGF1R_20145208_ChIP-Seq_DFB_Human1.57942148
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55355601
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55224493
43ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.53901462
44TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.51503330
45DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.51185887
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.49023273
47LXR_22292898_ChIP-Seq_THP-1_Human1.48269086
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.46289332
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44766973
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44601982
51EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44580413
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.43066270
53REST_21632747_ChIP-Seq_MESCs_Mouse1.39706451
54CLOCK_20551151_ChIP-Seq_293T_Human1.37350286
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.36424425
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35435007
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35387888
58ISL1_27105846_Chip-Seq_CPCs_Mouse1.35229407
59ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.34483433
60RING1B_27294783_Chip-Seq_NPCs_Mouse1.34051794
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33746004
62EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32203794
63RARB_27405468_Chip-Seq_BRAIN_Mouse1.31820249
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26607357
65CTCF_27219007_Chip-Seq_Bcells_Human1.24347609
66CREB1_26743006_Chip-Seq_LNCaP_Human1.22042802
67CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20755020
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19481942
69REST_18959480_ChIP-ChIP_MESCs_Mouse1.19250220
70TP53_20018659_ChIP-ChIP_R1E_Mouse1.18567257
71RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18415156
72ELK4_26923725_Chip-Seq_MESODERM_Mouse1.18160743
73FOXA2_19822575_ChIP-Seq_HepG2_Human1.17345064
74RNF2_27304074_Chip-Seq_NSC_Mouse1.16490504
75TET1_21490601_ChIP-Seq_MESCs_Mouse1.16188657
76TET1_21451524_ChIP-Seq_MESCs_Mouse1.14763828
77FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14342341
78ZNF274_21170338_ChIP-Seq_K562_Hela1.14203589
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13555182
80PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12973282
81ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11291068
82P68_20966046_ChIP-Seq_HELA_Human1.10587932
83GBX2_23144817_ChIP-Seq_PC3_Human1.09507118
84SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09046284
85SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08953685
86EP300_21415370_ChIP-Seq_HL-1_Mouse1.08339059
87TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08137579
88ESR2_21235772_ChIP-Seq_MCF-7_Human1.06847373
89SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.06844495
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06525412
91IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06445381
92NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.06164972
93KDM2B_26808549_Chip-Seq_DND41_Human1.04888655
94CBX2_27304074_Chip-Seq_ESCs_Mouse1.03075260
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03060854
96AR_19668381_ChIP-Seq_PC3_Human1.01343335
97RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01192374
98NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00817341
99ERA_21632823_ChIP-Seq_H3396_Human1.00455871
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99212500
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98656425
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98511872
103UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98406137
104SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98385848
105FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98261825
106AHR_22903824_ChIP-Seq_MCF-7_Human0.98189246
107GATA1_26923725_Chip-Seq_HPCs_Mouse0.97561844
108SMC4_20622854_ChIP-Seq_HELA_Human0.97119885
109PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.96896805
110PHF8_20622854_ChIP-Seq_HELA_Human0.95786824
111KDM2B_26808549_Chip-Seq_JURKAT_Human0.95783116
112SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93971101
113IRF1_19129219_ChIP-ChIP_H3396_Human0.92529845
114RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92499725
115CDX2_20551321_ChIP-Seq_CACO-2_Human0.92263582
116ESR1_21235772_ChIP-Seq_MCF-7_Human0.91354660
117P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91026174
118SOX2_21211035_ChIP-Seq_LN229_Gbm0.90546442
119SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.90437477
120ESR1_20079471_ChIP-ChIP_T-47D_Human0.90167158
121CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89758153
122RACK7_27058665_Chip-Seq_MCF-7_Human0.89718526
123TRIM28_21343339_ChIP-Seq_HEK293_Human0.88522997
124MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.87878154
125SMAD4_21741376_ChIP-Seq_HESCs_Human0.87788251
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87448914
127E2F1_20622854_ChIP-Seq_HELA_Human0.87269297
128SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86780010
129RARB_24833708_ChIP-Seq_LIVER_Mouse0.86372294
130SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86241110
131SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.85746807
132CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84524670
133BCL6_27268052_Chip-Seq_Bcells_Human0.84360656
134YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83958935
135CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83414309
136SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83373970
137OCT4_19829295_ChIP-Seq_ESCs_Human0.82785731
138ZNF263_19887448_ChIP-Seq_K562_Human0.82509026
139SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.82379902
140CTCF_20526341_ChIP-Seq_ESCs_Human0.82346060
141SOX3_22085726_ChIP-Seq_NPCs_Mouse0.81139686
142RAC3_21632823_ChIP-Seq_H3396_Human0.79253977
143EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.78502746
144FOXP1_21924763_ChIP-Seq_HESCs_Human0.78187822

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.49232136
2MP0002837_dystrophic_cardiac_calcinosis3.50339755
3MP0002822_catalepsy3.49896500
4MP0003122_maternal_imprinting3.14152739
5MP0002139_abnormal_hepatobiliary_system3.06912906
6MP0005257_abnormal_intraocular_pressure2.64525395
7MP0003252_abnormal_bile_duct2.54976537
8MP0005365_abnormal_bile_salt2.52142717
9MP0005220_abnormal_exocrine_pancreas2.38984253
10MP0002909_abnormal_adrenal_gland2.31837902
11MP0005645_abnormal_hypothalamus_physiol2.26564447
12MP0003880_abnormal_central_pattern2.21191510
13MP0001529_abnormal_vocalization2.15177321
14MP0004859_abnormal_synaptic_plasticity2.06072065
15MP0002638_abnormal_pupillary_reflex1.94644994
16MP0001944_abnormal_pancreas_morphology1.92592795
17MP0003121_genomic_imprinting1.91422540
18MP0003787_abnormal_imprinting1.91022064
19MP0001984_abnormal_olfaction1.90194008
20MP0004133_heterotaxia1.90178119
21MP0008789_abnormal_olfactory_epithelium1.89893852
22MP0005360_urolithiasis1.86838972
23MP0001849_ear_inflammation1.86680494
24MP0005248_abnormal_Harderian_gland1.75831812
25MP0005646_abnormal_pituitary_gland1.71029801
26MP0002928_abnormal_bile_duct1.68797157
27MP0000678_abnormal_parathyroid_gland1.66668243
28MP0009780_abnormal_chondrocyte_physiolo1.63873300
29MP0000778_abnormal_nervous_system1.63361700
30MP0002938_white_spotting1.59451407
31MP0004233_abnormal_muscle_weight1.59056363
32MP0003283_abnormal_digestive_organ1.58535673
33MP0003868_abnormal_feces_composition1.53484634
34MP0003942_abnormal_urinary_system1.50609947
35MP0003635_abnormal_synaptic_transmissio1.50274404
36MP0000566_synostosis1.49847522
37MP0002234_abnormal_pharynx_morphology1.48718085
38MP0002249_abnormal_larynx_morphology1.47563358
39MP0005423_abnormal_somatic_nervous1.46890267
40MP0000538_abnormal_urinary_bladder1.46860658
41MP0001502_abnormal_circadian_rhythm1.44843911
42MP0005499_abnormal_olfactory_system1.43652069
43MP0005394_taste/olfaction_phenotype1.43652069
44MP0003123_paternal_imprinting1.43499325
45MP0005085_abnormal_gallbladder_physiolo1.43093338
46MP0006276_abnormal_autonomic_nervous1.41145427
47MP0002572_abnormal_emotion/affect_behav1.39576260
48MP0003938_abnormal_ear_development1.38655853
49MP0002653_abnormal_ependyma_morphology1.37926837
50MP0002063_abnormal_learning/memory/cond1.37910852
51MP0003879_abnormal_hair_cell1.37556006
52MP0003119_abnormal_digestive_system1.35338143
53MP0005187_abnormal_penis_morphology1.33819451
54MP0004043_abnormal_pH_regulation1.33816125
55MP0002693_abnormal_pancreas_physiology1.33694024
56MP0002734_abnormal_mechanical_nocicepti1.33163210
57MP0000013_abnormal_adipose_tissue1.31594413
58MP0010386_abnormal_urinary_bladder1.31357710
59MP0001270_distended_abdomen1.30852321
60MP0001188_hyperpigmentation1.30257782
61MP0001666_abnormal_nutrient_absorption1.29353670
62MP0010030_abnormal_orbit_morphology1.29029461
63MP0005083_abnormal_biliary_tract1.28045900
64MP0006292_abnormal_olfactory_placode1.27675024
65MP0004885_abnormal_endolymph1.27203535
66MP0002882_abnormal_neuron_morphology1.26597630
67MP0002876_abnormal_thyroid_physiology1.26058238
68MP0002751_abnormal_autonomic_nervous1.25942582
69MP0003115_abnormal_respiratory_system1.24081482
70MP0003385_abnormal_body_wall1.23323504
71MP0002272_abnormal_nervous_system1.22272066
72MP0002078_abnormal_glucose_homeostasis1.21743103
73MP0004858_abnormal_nervous_system1.21723238
74MP0000026_abnormal_inner_ear1.21514314
75MP0003183_abnormal_peptide_metabolism1.21290405
76MP0003195_calcinosis1.21143774
77MP0003136_yellow_coat_color1.19644099
78MP0009745_abnormal_behavioral_response1.19108304
79MP0000049_abnormal_middle_ear1.18265253
80MP0009053_abnormal_anal_canal1.16646831
81MP0003172_abnormal_lysosome_physiology1.16495701
82MP0004019_abnormal_vitamin_homeostasis1.15124377
83MP0000613_abnormal_salivary_gland1.12869356
84MP0010234_abnormal_vibrissa_follicle1.12762000
85MP0002064_seizures1.11028800
86MP0008961_abnormal_basal_metabolism1.09644472
87MP0000537_abnormal_urethra_morphology1.08555985
88MP0006072_abnormal_retinal_apoptosis1.08421625
89MP0002752_abnormal_somatic_nervous1.08010575
90MP0003329_amyloid_beta_deposits1.07489051
91MP0002233_abnormal_nose_morphology1.07334217
92MP0009672_abnormal_birth_weight1.07300437
93MP0000003_abnormal_adipose_tissue1.06661668
94MP0000534_abnormal_ureter_morphology1.05705011
95MP0004145_abnormal_muscle_electrophysio1.04848288
96MP0000428_abnormal_craniofacial_morphol1.04438784
97MP0003755_abnormal_palate_morphology1.01453960
98MP0002152_abnormal_brain_morphology0.99933150
99MP0002735_abnormal_chemical_nociception0.99828701
100MP0001970_abnormal_pain_threshold0.99669061
101MP0003861_abnormal_nervous_system0.97701644
102MP0005386_behavior/neurological_phenoty0.97579369
103MP0004924_abnormal_behavior0.97579369
104MP0003935_abnormal_craniofacial_develop0.96667101
105MP0003878_abnormal_ear_physiology0.95155126
106MP0005377_hearing/vestibular/ear_phenot0.95155126
107MP0002102_abnormal_ear_morphology0.94436829
108MP0009046_muscle_twitch0.91097634
109MP0005379_endocrine/exocrine_gland_phen0.90947986
110MP0002733_abnormal_thermal_nociception0.90811806
111MP0000462_abnormal_digestive_system0.90771504
112MP0010329_abnormal_lipoprotein_level0.90199578
113MP0000631_abnormal_neuroendocrine_gland0.88593562
114MP0005551_abnormal_eye_electrophysiolog0.86181008
115MP0002177_abnormal_outer_ear0.86129960
116MP0002184_abnormal_innervation0.85269487
117MP0004085_abnormal_heartbeat0.84828046
118MP0001485_abnormal_pinna_reflex0.84731561
119MP0000639_abnormal_adrenal_gland0.84303775
120MP0001968_abnormal_touch/_nociception0.84207722
121MP0003011_delayed_dark_adaptation0.84201175
122MP0001905_abnormal_dopamine_level0.83984718
123MP0000579_abnormal_nail_morphology0.83461256
124MP0001664_abnormal_digestion0.83010723
125MP0005253_abnormal_eye_physiology0.82470511
126MP0002067_abnormal_sensory_capabilities0.82356175
127MP0001486_abnormal_startle_reflex0.81904747
128MP0004381_abnormal_hair_follicle0.81846267
129MP0005332_abnormal_amino_acid0.81104980
130MP0001963_abnormal_hearing_physiology0.80024121
131MP0000955_abnormal_spinal_cord0.79477829
132MP0002066_abnormal_motor_capabilities/c0.79063870
133MP0004742_abnormal_vestibular_system0.78892026
134MP0005367_renal/urinary_system_phenotyp0.78291395
135MP0000516_abnormal_urinary_system0.78291395
136MP0002896_abnormal_bone_mineralization0.78226420
137MP0002736_abnormal_nociception_after0.76170685
138MP0004134_abnormal_chest_morphology0.75943574
139MP0002557_abnormal_social/conspecific_i0.73249040
140MP0003959_abnormal_lean_body0.72896240
141MP0009250_abnormal_appendicular_skeleto0.72361815
142MP0000751_myopathy0.72333692
143MP0003953_abnormal_hormone_level0.71907713
144MP0000467_abnormal_esophagus_morphology0.71100672
145MP0004811_abnormal_neuron_physiology0.71011855
146MP0008875_abnormal_xenobiotic_pharmacok0.70625982
147MP0001324_abnormal_eye_pigmentation0.70158213
148MP0004270_analgesia0.70090182
149MP0002069_abnormal_eating/drinking_beha0.69634427
150MP0003890_abnormal_embryonic-extraembry0.68987320
151MP0003705_abnormal_hypodermis_morpholog0.67780559
152MP0001299_abnormal_eye_distance/0.67171861
153MP0003137_abnormal_impulse_conducting0.66978163

Predicted human phenotypes

RankGene SetZ-score
1Agitation (HP:0000713)5.19162757
2Hypoglycemic seizures (HP:0002173)4.76404932
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.13213393
4Symptomatic seizures (HP:0011145)3.81231672
5Abnormality of aromatic amino acid family metabolism (HP:0004338)3.79469838
6Hyperglycemia (HP:0003074)3.64756543
7Long toe (HP:0010511)3.58829215
8Ketoacidosis (HP:0001993)3.49472346
9Hepatoblastoma (HP:0002884)3.39479834
10Insulin-resistant diabetes mellitus (HP:0000831)3.28918723
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.22138645
12Hyperinsulinemic hypoglycemia (HP:0000825)3.21830781
13Hypoglycemic coma (HP:0001325)3.10897226
14Ketosis (HP:0001946)3.03770146
15Late onset (HP:0003584)3.00724172
16Mitral stenosis (HP:0001718)2.99316167
17Abnormality of endocrine pancreas physiology (HP:0012093)2.93853305
18Abnormality of the pancreatic islet cells (HP:0006476)2.93853305
19Myokymia (HP:0002411)2.91049654
20Abnormality of calcium-phosphate metabolism (HP:0100530)2.86615274
21Abnormal respiratory motile cilium physiology (HP:0012261)2.81899344
22Neoplasm of the heart (HP:0100544)2.79463336
23Abnormal respiratory motile cilium morphology (HP:0005938)2.79036732
24Abnormal respiratory epithelium morphology (HP:0012253)2.79036732
25Ependymoma (HP:0002888)2.71371110
26Abnormal ciliary motility (HP:0012262)2.66223132
27Abnormality of the lower motor neuron (HP:0002366)2.65740457
28Gait imbalance (HP:0002141)2.61790484
29Hypoplasia of the brainstem (HP:0002365)2.60354876
30Aplasia/Hypoplasia of the brainstem (HP:0007362)2.60354876
31Rhinitis (HP:0012384)2.60253668
32Amblyopia (HP:0000646)2.60193327
33Postural tremor (HP:0002174)2.57203559
34Unilateral renal agenesis (HP:0000122)2.56604384
35Hyperglycinemia (HP:0002154)2.54816323
36Occipital encephalocele (HP:0002085)2.52509294
37Restlessness (HP:0000711)2.51419600
38Cortical dysplasia (HP:0002539)2.50928115
39Retinal dysplasia (HP:0007973)2.48079285
40Deep venous thrombosis (HP:0002625)2.40637860
41Posterior subcapsular cataract (HP:0007787)2.40295103
42Lymphangioma (HP:0100764)2.39853013
43Turricephaly (HP:0000262)2.39484833
44Pancreatic islet-cell hyperplasia (HP:0004510)2.39258271
45Hamartoma of the eye (HP:0010568)2.33993402
46Insulin resistance (HP:0000855)2.33490052
47Large for gestational age (HP:0001520)2.32633190
48Congenital primary aphakia (HP:0007707)2.32401741
49Neonatal hypoglycemia (HP:0001998)2.31898191
50Ankle clonus (HP:0011448)2.31767992
51Poor suck (HP:0002033)2.29458532
52Abnormality of glycine metabolism (HP:0010895)2.27357931
53Abnormality of serine family amino acid metabolism (HP:0010894)2.27357931
54Pheochromocytoma (HP:0002666)2.25588273
55Hyperglycinuria (HP:0003108)2.23182603
56Nephrogenic diabetes insipidus (HP:0009806)2.23153634
57Progressive sensorineural hearing impairment (HP:0000408)2.22672428
58Medial flaring of the eyebrow (HP:0010747)2.20667382
59Limb-girdle muscle atrophy (HP:0003797)2.16727824
60Congenital malformation of the right heart (HP:0011723)2.14451615
61Double outlet right ventricle (HP:0001719)2.14451615
62Generalized hyperpigmentation (HP:0007440)2.13168996
63Abnormal pancreas size (HP:0012094)2.10556899
64Nephronophthisis (HP:0000090)2.10519716
65Abnormality of the aortic arch (HP:0012303)2.09922680
66Conjugated hyperbilirubinemia (HP:0002908)2.08589563
67Dynein arm defect of respiratory motile cilia (HP:0012255)2.06800023
68Absent/shortened dynein arms (HP:0200106)2.06800023
69Hand muscle atrophy (HP:0009130)2.04541482
70Menstrual irregularities (HP:0000858)2.04055148
71Hypsarrhythmia (HP:0002521)2.03644018
72EEG with generalized epileptiform discharges (HP:0011198)2.03556077
73Pachygyria (HP:0001302)2.03450794
74Sleep apnea (HP:0010535)2.02994090
75Abnormal eating behavior (HP:0100738)2.02870745
76Chronic bronchitis (HP:0004469)2.01612445
77Gout (HP:0001997)2.01482771
78Wrist flexion contracture (HP:0001239)2.01037890
79Growth hormone excess (HP:0000845)2.00766771
80Neoplasm of the peripheral nervous system (HP:0100007)1.99935274
81Decreased circulating renin level (HP:0003351)1.99862842
82Urinary urgency (HP:0000012)1.99543064
83Hypercortisolism (HP:0001578)1.98658897
84Abnormality of the astrocytes (HP:0100707)1.96833826
85Astrocytoma (HP:0009592)1.96833826
86Specific learning disability (HP:0001328)1.95946951
87Absent speech (HP:0001344)1.95363231
88Lissencephaly (HP:0001339)1.94986084
89Epidermoid cyst (HP:0200040)1.94860460
90Polyphagia (HP:0002591)1.94688669
91Enlarged kidneys (HP:0000105)1.94183069
92Neuroendocrine neoplasm (HP:0100634)1.94039566
93Abnormality of glutamine family amino acid metabolism (HP:0010902)1.93546724
94True hermaphroditism (HP:0010459)1.93454798
95Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.93237732
96Renal duplication (HP:0000075)1.92935193
97Hyperventilation (HP:0002883)1.92598141
98Drooling (HP:0002307)1.91902334
99Macroorchidism (HP:0000053)1.91821105
100Polymicrogyria (HP:0002126)1.90894009
101Severe muscular hypotonia (HP:0006829)1.89685391
102Congenital glaucoma (HP:0001087)1.89117083
103Epileptiform EEG discharges (HP:0011182)1.87154564
104Exotropia (HP:0000577)1.85647291
105Abnormality of purine metabolism (HP:0004352)1.84501358
106Vaginal atresia (HP:0000148)1.83790277
107Type II lissencephaly (HP:0007260)1.83529784
108Open mouth (HP:0000194)1.83444695
109Cystic liver disease (HP:0006706)1.80991786
110Severe Myopia (HP:0011003)1.79235660
111Spastic tetraplegia (HP:0002510)1.78559115
112Vitreoretinal degeneration (HP:0000655)1.76975656
113Genital tract atresia (HP:0001827)1.75595671
114Tubulointerstitial nephritis (HP:0001970)1.74412246
115Renal dysplasia (HP:0000110)1.73756741
116Scapular winging (HP:0003691)1.72804172
117Advanced eruption of teeth (HP:0006288)1.72694080
118Chronic hepatic failure (HP:0100626)1.72538482
119Neoplasm of the adrenal gland (HP:0100631)1.71753885
120Esotropia (HP:0000565)1.71237083
121Central scotoma (HP:0000603)1.69898207
122Elfin facies (HP:0004428)1.69625458
123Progressive cerebellar ataxia (HP:0002073)1.68887091
124Scrotal hypoplasia (HP:0000046)1.68811280
125Pancreatic cysts (HP:0001737)1.68320761
126Shoulder girdle muscle weakness (HP:0003547)1.68211594
127Excessive salivation (HP:0003781)1.67774834
128Renal hypoplasia (HP:0000089)1.67345435
129Delayed CNS myelination (HP:0002188)1.66991390
130Labial hypoplasia (HP:0000066)1.66501142
131Back pain (HP:0003418)1.66284297
132Limb dystonia (HP:0002451)1.64931341
133Abnormality of the labia minora (HP:0012880)1.63052437
134Abnormality of midbrain morphology (HP:0002418)1.62991757
135Molar tooth sign on MRI (HP:0002419)1.62991757
136Bicornuate uterus (HP:0000813)1.62911440
137Abnormality of the corticospinal tract (HP:0002492)1.62614662
138Pancreatic fibrosis (HP:0100732)1.62339160
139Down-sloping shoulders (HP:0200021)1.61473732
140Abnormality of the renal medulla (HP:0100957)1.60654605
141Hypothermia (HP:0002045)1.60180508
142Aneurysm (HP:0002617)1.60000572
143Hypoplasia of the corpus callosum (HP:0002079)1.58516859
144Xanthomatosis (HP:0000991)1.58204708
145Hyperactive renin-angiotensin system (HP:0000841)1.57817863
146Renovascular hypertension (HP:0100817)1.57257080
147Failure to thrive in infancy (HP:0001531)1.56127529
148Subcapsular cataract (HP:0000523)1.55996377
149Abnormality of the intervertebral disk (HP:0005108)1.55856241
150Aplasia/Hypoplasia affecting the retina (HP:0008061)1.55673997
151Prolonged QT interval (HP:0001657)1.55570079
152Muscular hypotonia of the trunk (HP:0008936)1.54719576
153Aplasia/hypoplasia of the uterus (HP:0008684)1.54606919
154Sclerocornea (HP:0000647)1.54022237
155Aplasia/Hypoplasia of the macula (HP:0008059)1.53882838
156Poor coordination (HP:0002370)1.53662046
157Postaxial hand polydactyly (HP:0001162)1.53625539
158Obsessive-compulsive behavior (HP:0000722)1.53273210
159Neonatal onset (HP:0003623)1.53191511
160Proximal amyotrophy (HP:0007126)1.52912397
161Abnormality of the intrinsic pathway (HP:0010989)1.52671532
162Thin bony cortex (HP:0002753)1.52531013
163Abnormality of monocarboxylic acid metabolism (HP:0010996)1.52504840
164Infertility (HP:0000789)1.52431121
165Tubular atrophy (HP:0000092)1.51965373
166Anosmia (HP:0000458)1.51872321
167Intrahepatic cholestasis (HP:0001406)1.51734329
168Alopecia of scalp (HP:0002293)1.50812356
169Insomnia (HP:0100785)1.49818491
170Hyperphosphatemia (HP:0002905)1.49136600
171Absent eyelashes (HP:0000561)1.49113465
172Myoglobinuria (HP:0002913)1.47741770
173Skin nodule (HP:0200036)1.47103487
174Myopathic facies (HP:0002058)1.46260600
175Progressive hearing impairment (HP:0001730)1.46074317
176Upper limb amyotrophy (HP:0009129)1.45604825
177Distal upper limb amyotrophy (HP:0007149)1.45604825
178Absent eyebrow (HP:0002223)1.45241224
179Spinal canal stenosis (HP:0003416)1.44507856
180Precocious puberty (HP:0000826)1.43480380
181Type II diabetes mellitus (HP:0005978)1.42820260
182Aplasia/Hypoplasia of the fovea (HP:0008060)1.41638533

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK33.50173921
2ERN13.37560663
3SIK13.11975566
4WNK33.03924013
5EPHB23.01987296
6INSRR2.93516125
7TRIB32.74322713
8CASK2.69560874
9EPHA22.59057480
10TRIM282.45457896
11TAOK32.41277146
12PAK62.31893270
13MAP4K22.15090934
14MARK12.05628622
15PINK11.98125577
16SIK21.94822493
17HIPK21.89396143
18MAP3K41.76864450
19LATS11.74915896
20CSNK1G31.73279115
21MAP3K101.69240270
22PASK1.68126016
23PRKD31.66644643
24WNK41.63512322
25DYRK1B1.60235103
26PDGFRA1.58369331
27PTK61.49437662
28MAPK151.47482904
29EPHA31.41560851
30STK38L1.38765954
31UHMK11.38016736
32NTRK11.33764593
33CSNK1G11.32384095
34EEF2K1.30098844
35CDK121.26477977
36EPHA41.25608035
37BRD41.25607319
38NEK11.19907599
39CDK191.19495508
40PHKG11.18945243
41PHKG21.18945243
42DYRK21.18180389
43KSR11.15952030
44BCKDK1.13417429
45FGFR41.13218064
46ERBB21.13036963
47PKN21.11130476
48FER1.09964767
49TESK21.08596604
50ICK1.04332531
51PTK21.03972471
52LIMK11.03670445
53LMTK21.01076304
54RIPK11.00111439
55TAOK10.98179914
56CAMK1G0.97556548
57ERBB30.96326757
58MAP3K60.95279811
59PRKCG0.94885427
60MINK10.93853617
61PAK30.91438537
62DYRK30.90113459
63PAK20.88119217
64DAPK20.85346457
65PRKCH0.84411328
66RET0.84307308
67MAP3K20.82135892
68SGK4940.81939051
69SGK2230.81939051
70MAP2K40.79519798
71FLT30.78767176
72RPS6KA20.77558993
73TTN0.76640561
74MARK20.75965964
75MAPK130.75025240
76FRK0.73143990
77MAP2K70.71939597
78WNK10.69496430
79CDK140.68902265
80MUSK0.66982767
81MTOR0.65045531
82CAMK40.63599000
83NTRK20.62279107
84MAP3K90.62121299
85GRK10.62101491
86KSR20.61446435
87CSNK1A10.60775548
88BCR0.60475701
89PRKCZ0.59538434
90STK380.59020837
91LATS20.58146858
92MST1R0.56081411
93PRKCE0.55679661
94MAP3K10.54275440
95NTRK30.53590829
96MAP3K70.53295278
97CDK11A0.53271334
98FGFR20.53069545
99CDK180.51753355
100MAP2K10.50856287
101CAMK2B0.50373849
102MET0.48978569
103DYRK1A0.48527684
104CDC42BPA0.47964571
105PIM20.47914527
106CDK150.47509495
107DDR20.47397984
108CSNK1A1L0.45878003
109PRKD10.44141675
110PRKCI0.43911959
111RPS6KA40.43370605
112MAPK90.41468460
113TIE10.41263009
114PKN10.41179706
115MAPK80.40928664
116TYRO30.40924197
117CSNK1G20.40396412
118DMPK0.40199938
119CAMK2D0.40130155
120STK390.39848488
121CDK50.38685003
122PRKAA10.38636462
123PRKACA0.38602290
124PRKD20.38338632
125YES10.37749709
126CAMKK10.37043528
127CAMK2G0.37000992
128EPHB10.36791700
129CAMK1D0.36239578
130CAMK2A0.35878757
131ROCK10.34499726
132MAP2K20.33973027
133TESK10.33918512
134RPS6KA10.33408594
135SRPK10.33032880
136ADRBK10.32475184
137SGK20.32220089

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.85779781
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.77893490
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62620269
4Sulfur metabolism_Homo sapiens_hsa009202.22706071
5Cyanoamino acid metabolism_Homo sapiens_hsa004601.93111237
6Fatty acid degradation_Homo sapiens_hsa000711.89834377
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.89539540
8Insulin secretion_Homo sapiens_hsa049111.83518731
9Steroid biosynthesis_Homo sapiens_hsa001001.81670084
10Tryptophan metabolism_Homo sapiens_hsa003801.81596917
11Butanoate metabolism_Homo sapiens_hsa006501.79112916
12Lysine degradation_Homo sapiens_hsa003101.75805670
13Protein export_Homo sapiens_hsa030601.73955076
14Type II diabetes mellitus_Homo sapiens_hsa049301.72929681
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.70793563
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68382955
17Nicotine addiction_Homo sapiens_hsa050331.63773788
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.55825240
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.51877279
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51229454
21Arginine biosynthesis_Homo sapiens_hsa002201.50869383
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.49432842
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.47323415
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.45844419
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43924917
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.42467671
27Fatty acid metabolism_Homo sapiens_hsa012121.42082646
28Chemical carcinogenesis_Homo sapiens_hsa052041.40711529
29N-Glycan biosynthesis_Homo sapiens_hsa005101.40354251
30Insulin resistance_Homo sapiens_hsa049311.37252003
31Retinol metabolism_Homo sapiens_hsa008301.33367460
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.26832134
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.26363399
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22016025
35Cocaine addiction_Homo sapiens_hsa050301.20987128
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18531999
37Collecting duct acid secretion_Homo sapiens_hsa049661.17603542
38Fructose and mannose metabolism_Homo sapiens_hsa000511.16403064
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.13757819
40Linoleic acid metabolism_Homo sapiens_hsa005911.12395331
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09773353
42Carbohydrate digestion and absorption_Homo sapiens_hsa049731.09198615
43Caffeine metabolism_Homo sapiens_hsa002321.07184650
44Fat digestion and absorption_Homo sapiens_hsa049751.07144635
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06128944
46Taste transduction_Homo sapiens_hsa047421.02680730
47Selenocompound metabolism_Homo sapiens_hsa004501.02296667
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01447274
49Folate biosynthesis_Homo sapiens_hsa007901.00826752
50Bile secretion_Homo sapiens_hsa049761.00749322
51Fatty acid elongation_Homo sapiens_hsa000621.00151207
52Peroxisome_Homo sapiens_hsa041461.00125733
53Insulin signaling pathway_Homo sapiens_hsa049100.99282543
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98539844
55Phenylalanine metabolism_Homo sapiens_hsa003600.95827837
56Dilated cardiomyopathy_Homo sapiens_hsa054140.93052474
57Dopaminergic synapse_Homo sapiens_hsa047280.92919219
58Endometrial cancer_Homo sapiens_hsa052130.87997281
59Notch signaling pathway_Homo sapiens_hsa043300.87809040
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.86648106
61Cholinergic synapse_Homo sapiens_hsa047250.85873618
62PPAR signaling pathway_Homo sapiens_hsa033200.84853254
63Propanoate metabolism_Homo sapiens_hsa006400.84285254
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.82659074
65Vibrio cholerae infection_Homo sapiens_hsa051100.81247273
66Axon guidance_Homo sapiens_hsa043600.80899684
67Chronic myeloid leukemia_Homo sapiens_hsa052200.80425444
68Oxidative phosphorylation_Homo sapiens_hsa001900.80294846
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79823631
70beta-Alanine metabolism_Homo sapiens_hsa004100.79810570
71Biosynthesis of amino acids_Homo sapiens_hsa012300.78631171
72Glucagon signaling pathway_Homo sapiens_hsa049220.77110847
73GABAergic synapse_Homo sapiens_hsa047270.76712426
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76278365
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75350987
76Glutamatergic synapse_Homo sapiens_hsa047240.74766174
77Renal cell carcinoma_Homo sapiens_hsa052110.74497141
78Cardiac muscle contraction_Homo sapiens_hsa042600.73401726
79Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73197152
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72292742
81Starch and sucrose metabolism_Homo sapiens_hsa005000.72045425
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71985022
83Synaptic vesicle cycle_Homo sapiens_hsa047210.71404925
84Circadian entrainment_Homo sapiens_hsa047130.71121069
85Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70741399
86Sphingolipid metabolism_Homo sapiens_hsa006000.69954619
87AMPK signaling pathway_Homo sapiens_hsa041520.67875887
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67722218
89Gap junction_Homo sapiens_hsa045400.67649984
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65879793
91Prolactin signaling pathway_Homo sapiens_hsa049170.65366649
92Basal cell carcinoma_Homo sapiens_hsa052170.64643535
93mTOR signaling pathway_Homo sapiens_hsa041500.64607103
94Tight junction_Homo sapiens_hsa045300.64443501
95Vitamin digestion and absorption_Homo sapiens_hsa049770.63632888
96Serotonergic synapse_Homo sapiens_hsa047260.63581587
97Glioma_Homo sapiens_hsa052140.63531849
98Histidine metabolism_Homo sapiens_hsa003400.63331010
99Complement and coagulation cascades_Homo sapiens_hsa046100.63137229
100Tyrosine metabolism_Homo sapiens_hsa003500.60685994
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.59465793
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58114447
103ABC transporters_Homo sapiens_hsa020100.57706808
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.57219154
105Pancreatic secretion_Homo sapiens_hsa049720.56392984
106Thyroid hormone synthesis_Homo sapiens_hsa049180.56233989
107Ether lipid metabolism_Homo sapiens_hsa005650.55523105
108Metabolic pathways_Homo sapiens_hsa011000.55497437
109Pyruvate metabolism_Homo sapiens_hsa006200.55157432
110Carbon metabolism_Homo sapiens_hsa012000.54110426
111Regulation of autophagy_Homo sapiens_hsa041400.53967617
112Sulfur relay system_Homo sapiens_hsa041220.53834436
113Arginine and proline metabolism_Homo sapiens_hsa003300.53594919
114Prion diseases_Homo sapiens_hsa050200.53565143
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53431931
116ErbB signaling pathway_Homo sapiens_hsa040120.53051687
117Parkinsons disease_Homo sapiens_hsa050120.53043400
118Huntingtons disease_Homo sapiens_hsa050160.52570714
119Phototransduction_Homo sapiens_hsa047440.52166479
120Bladder cancer_Homo sapiens_hsa052190.51425525
121Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50916878
122Mineral absorption_Homo sapiens_hsa049780.49928570
123Amphetamine addiction_Homo sapiens_hsa050310.49539943
124Long-term depression_Homo sapiens_hsa047300.49253227
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47531959
126Hippo signaling pathway_Homo sapiens_hsa043900.46996948
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46596702
128Hedgehog signaling pathway_Homo sapiens_hsa043400.46200400
129Vitamin B6 metabolism_Homo sapiens_hsa007500.44554052
130Colorectal cancer_Homo sapiens_hsa052100.43911246
131Arachidonic acid metabolism_Homo sapiens_hsa005900.43805161
132Estrogen signaling pathway_Homo sapiens_hsa049150.43598093
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43249587
134Morphine addiction_Homo sapiens_hsa050320.41511600
135cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39966341
136Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39745507
137Melanogenesis_Homo sapiens_hsa049160.39554340
138SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39524616
139Wnt signaling pathway_Homo sapiens_hsa043100.39463789
140Galactose metabolism_Homo sapiens_hsa000520.37435435
141Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36179978
142cAMP signaling pathway_Homo sapiens_hsa040240.35585573

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