CACNA1D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.58141340
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.24412116
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.98288619
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.52788663
5vocalization behavior (GO:0071625)4.40045201
6locomotory exploration behavior (GO:0035641)4.30424787
7synaptic vesicle exocytosis (GO:0016079)4.27909722
8synaptic vesicle maturation (GO:0016188)4.17723799
9ionotropic glutamate receptor signaling pathway (GO:0035235)4.09711049
10regulation of synaptic vesicle exocytosis (GO:2000300)4.06392707
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.04039977
12regulation of glutamate receptor signaling pathway (GO:1900449)3.93715555
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.88801187
14glutamate receptor signaling pathway (GO:0007215)3.85282501
15serotonin metabolic process (GO:0042428)3.81008793
16neuron cell-cell adhesion (GO:0007158)3.80140851
17glutamate secretion (GO:0014047)3.76435259
18protein localization to synapse (GO:0035418)3.72728753
19detection of calcium ion (GO:0005513)3.69484564
20indolalkylamine metabolic process (GO:0006586)3.68932175
21synaptic transmission, glutamatergic (GO:0035249)3.68465871
22regulation of synaptic vesicle transport (GO:1902803)3.64627892
23primary amino compound metabolic process (GO:1901160)3.62082645
24synaptic vesicle docking involved in exocytosis (GO:0016081)3.58290530
25water-soluble vitamin biosynthetic process (GO:0042364)3.57327332
26neuronal action potential propagation (GO:0019227)3.55750655
27regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.46559768
28neurotransmitter secretion (GO:0007269)3.45497930
29dendritic spine morphogenesis (GO:0060997)3.44449715
30neuron-neuron synaptic transmission (GO:0007270)3.43830485
31L-fucose catabolic process (GO:0042355)3.41766586
32fucose catabolic process (GO:0019317)3.41766586
33L-fucose metabolic process (GO:0042354)3.41766586
34gamma-aminobutyric acid transport (GO:0015812)3.40037268
35regulation of neuronal synaptic plasticity (GO:0048168)3.34677749
36long-term memory (GO:0007616)3.34087222
37chemosensory behavior (GO:0007635)3.30746690
38neurotransmitter-gated ion channel clustering (GO:0072578)3.29836399
39epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.29083140
40cerebellar Purkinje cell differentiation (GO:0021702)3.25973006
41gamma-aminobutyric acid signaling pathway (GO:0007214)3.25509473
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.22475341
43exploration behavior (GO:0035640)3.21576390
44regulation of calcium ion-dependent exocytosis (GO:0017158)3.20530904
45synaptic vesicle endocytosis (GO:0048488)3.17388950
46positive regulation of membrane potential (GO:0045838)3.16266021
47regulation of long-term neuronal synaptic plasticity (GO:0048169)3.14736156
48tryptophan catabolic process (GO:0006569)3.14704446
49indole-containing compound catabolic process (GO:0042436)3.14704446
50indolalkylamine catabolic process (GO:0046218)3.14704446
51cellular potassium ion homeostasis (GO:0030007)3.14494093
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.14387813
53regulation of vesicle fusion (GO:0031338)3.12476517
54indole-containing compound metabolic process (GO:0042430)3.12273824
55negative regulation of cytosolic calcium ion concentration (GO:0051481)3.12245527
56neuron recognition (GO:0008038)3.11404270
57regulation of postsynaptic membrane potential (GO:0060078)3.10045460
58kidney morphogenesis (GO:0060993)3.08297747
59transmission of nerve impulse (GO:0019226)3.06673617
60cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.06150422
61presynaptic membrane assembly (GO:0097105)3.06001398
62kynurenine metabolic process (GO:0070189)3.05028445
63insulin secretion (GO:0030073)3.04643433
64regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.04525758
65parturition (GO:0007567)3.03103957
66regulation of mesoderm development (GO:2000380)2.98138867
67dendrite morphogenesis (GO:0048813)2.97996244
68* membrane depolarization during action potential (GO:0086010)2.96294162
69innervation (GO:0060384)2.96219342
70nephron epithelium morphogenesis (GO:0072088)2.93257258
71nephron tubule morphogenesis (GO:0072078)2.93257258
72startle response (GO:0001964)2.91547291
73layer formation in cerebral cortex (GO:0021819)2.91357748
74positive regulation of fatty acid oxidation (GO:0046321)2.89747048
75regulation of hippo signaling (GO:0035330)2.89651651
76activation of protein kinase A activity (GO:0034199)2.89580553
77neurotransmitter transport (GO:0006836)2.88349506
78cellular ketone body metabolic process (GO:0046950)2.86655726
79neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.85005516
80postsynaptic membrane organization (GO:0001941)2.84827667
81regulation of neurotransmitter secretion (GO:0046928)2.84490654
82axonal fasciculation (GO:0007413)2.83937008
83positive regulation of fatty acid beta-oxidation (GO:0032000)2.83498491
84positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.82620193
85* membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.80827315
86regulation of synaptic transmission, glutamatergic (GO:0051966)2.80789152
87synapse assembly (GO:0007416)2.79751917
88positive regulation of synaptic transmission, GABAergic (GO:0032230)2.79628512
89positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.79467921
90positive regulation of exocytosis (GO:0045921)2.79206045
91long-term synaptic potentiation (GO:0060291)2.78800090
92dendritic spine organization (GO:0097061)2.78666165
93neuromuscular process controlling posture (GO:0050884)2.78361825
94cell proliferation in forebrain (GO:0021846)2.77269383
95positive regulation of synapse maturation (GO:0090129)2.76582541
96protein targeting to Golgi (GO:0000042)2.76442270
97presynaptic membrane organization (GO:0097090)2.76182750
98regulation of synaptic plasticity (GO:0048167)2.75336760
99axoneme assembly (GO:0035082)2.73994431
100regulation of exocytosis (GO:0017157)2.73692705
101epithelial cilium movement (GO:0003351)2.73356026
102* membrane depolarization (GO:0051899)2.73278173
103* calcium ion import (GO:0070509)2.72914212
104membrane hyperpolarization (GO:0060081)2.72788820
105cell communication by electrical coupling (GO:0010644)2.72583527
106G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.72237220
107neuronal ion channel clustering (GO:0045161)2.70731446
108spinal cord motor neuron differentiation (GO:0021522)2.70378075
109neuronal action potential (GO:0019228)2.69747040
110interkinetic nuclear migration (GO:0022027)2.68177041
111regulation of action potential (GO:0098900)2.67506783
112detection of light stimulus involved in visual perception (GO:0050908)2.67472225
113detection of light stimulus involved in sensory perception (GO:0050962)2.67472225
114regulation of synapse structural plasticity (GO:0051823)2.66940893
115negative regulation of synaptic transmission, GABAergic (GO:0032229)2.66179799
116suckling behavior (GO:0001967)2.64603034
117sulfation (GO:0051923)2.64310563
118nonmotile primary cilium assembly (GO:0035058)2.64232012
119vesicle transport along microtubule (GO:0047496)2.63732853
120calcium ion-dependent exocytosis (GO:0017156)2.63283027
121proline transport (GO:0015824)2.62684230
122tryptophan metabolic process (GO:0006568)2.62158567
123cellular response to ATP (GO:0071318)2.61903496
124inner ear receptor cell development (GO:0060119)2.61724041
125protein polyglutamylation (GO:0018095)2.61432407
126regulation of neurotransmitter transport (GO:0051588)2.61431328
127negative regulation of hormone metabolic process (GO:0032351)2.61132015
128negative regulation of hormone biosynthetic process (GO:0032353)2.61132015
129glycine transport (GO:0015816)2.60576560
130negative regulation of transcription regulatory region DNA binding (GO:2000678)2.60499607
131response to auditory stimulus (GO:0010996)2.60246463
132righting reflex (GO:0060013)2.59440194
133regulation of ARF protein signal transduction (GO:0032012)2.59291984
134negative regulation of appetite (GO:0032099)2.59140587
135negative regulation of response to food (GO:0032096)2.59140587
136positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.57717983
137positive regulation of neurotransmitter secretion (GO:0001956)2.57708241
138regulation of neurotransmitter levels (GO:0001505)2.56244574
139reflex (GO:0060004)2.56163958
140cerebellar Purkinje cell layer development (GO:0021680)2.56151122
141nerve growth factor signaling pathway (GO:0038180)2.55892552
142regulation of dendritic spine morphogenesis (GO:0061001)2.55251911
143positive regulation of dendritic spine morphogenesis (GO:0061003)2.55083959
144positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.54960009
145positive regulation of vesicle fusion (GO:0031340)2.54801264
146cilium movement (GO:0003341)2.54021448
147action potential (GO:0001508)2.53038263
148cAMP catabolic process (GO:0006198)2.51913162
149ketone body metabolic process (GO:1902224)2.51566318
150endocrine pancreas development (GO:0031018)2.51092892
151negative regulation of systemic arterial blood pressure (GO:0003085)2.49408762
152synaptic transmission, cholinergic (GO:0007271)2.48420790
153regulation of neurotransmitter uptake (GO:0051580)2.47005728
154positive regulation of sodium ion transmembrane transport (GO:1902307)2.46233618
155urinary tract smooth muscle contraction (GO:0014848)2.46133875
156response to pheromone (GO:0019236)2.43554204
157behavioral response to ethanol (GO:0048149)2.43104740
158detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.42697857
159appendage development (GO:0048736)2.41625826
160limb development (GO:0060173)2.41625826
161somite development (GO:0061053)2.39007008
162magnesium ion transport (GO:0015693)2.36581077
163cornea development in camera-type eye (GO:0061303)2.36132795
164protein localization to cilium (GO:0061512)2.35525130
165negative regulation of telomere maintenance (GO:0032205)2.35288856
166cyclic nucleotide catabolic process (GO:0009214)2.34615981
167dentate gyrus development (GO:0021542)2.34423798
168renal tubule morphogenesis (GO:0061333)2.33029528
169glycerophospholipid catabolic process (GO:0046475)2.32046790
170dopamine transport (GO:0015872)2.31755174
171DNA deamination (GO:0045006)2.31487785
172oxidative demethylation (GO:0070989)2.31292562
173behavioral defense response (GO:0002209)2.31003189
174behavioral fear response (GO:0001662)2.31003189
175adaptation of signaling pathway (GO:0023058)2.29948704
176endoderm formation (GO:0001706)2.29909885
177peristalsis (GO:0030432)2.29403168
178neurotransmitter metabolic process (GO:0042133)2.29074054
179retinal ganglion cell axon guidance (GO:0031290)2.28930989
180cilium or flagellum-dependent cell motility (GO:0001539)2.28564908
181protein complex biogenesis (GO:0070271)2.28445137
182cell differentiation in spinal cord (GO:0021515)2.27015086
183regulation of gene silencing by RNA (GO:0060966)2.26495369
184regulation of posttranscriptional gene silencing (GO:0060147)2.26495369
185regulation of gene silencing by miRNA (GO:0060964)2.26495369
186regulation of synapse maturation (GO:0090128)2.24846177
187benzene-containing compound metabolic process (GO:0042537)2.24401259

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.22240843
2GBX2_23144817_ChIP-Seq_PC3_Human3.66885320
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.73945943
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70442660
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.63054065
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.61236371
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.35637459
8DROSHA_22980978_ChIP-Seq_HELA_Human2.33117448
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.30010856
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28045749
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.24437657
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.24437657
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24076350
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23929410
15* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.21210181
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20545954
17* EZH2_27304074_Chip-Seq_ESCs_Mouse2.16984542
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.10857870
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99900154
20* EZH2_27294783_Chip-Seq_ESCs_Mouse1.94195723
21* RARB_27405468_Chip-Seq_BRAIN_Mouse1.92202915
22* RNF2_27304074_Chip-Seq_ESCs_Mouse1.91020878
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90692570
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84461998
25IGF1R_20145208_ChIP-Seq_DFB_Human1.80062692
26* SMAD4_21799915_ChIP-Seq_A2780_Human1.78674199
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76055158
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75571559
29* REST_18959480_ChIP-ChIP_MESCs_Mouse1.75369753
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74486038
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73936411
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69354394
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67770780
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67066816
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66749817
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65356583
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60586533
38ER_23166858_ChIP-Seq_MCF-7_Human1.51105627
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.51055726
40EWS_26573619_Chip-Seq_HEK293_Human1.50431449
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.50429957
42P300_19829295_ChIP-Seq_ESCs_Human1.50378109
43* STAT3_23295773_ChIP-Seq_U87_Human1.46828319
44TAF15_26573619_Chip-Seq_HEK293_Human1.43267783
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42588251
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40890400
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40240989
48* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39981226
49* SMAD3_21741376_ChIP-Seq_EPCs_Human1.37399531
50IRF1_19129219_ChIP-ChIP_H3396_Human1.36759100
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36140771
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34422539
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33853874
54* SOX2_21211035_ChIP-Seq_LN229_Gbm1.33683296
55* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32333096
56* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31903534
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31057360
58AR_21572438_ChIP-Seq_LNCaP_Human1.30815766
59* TCF4_23295773_ChIP-Seq_U87_Human1.27493488
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27481509
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.25540444
62AR_19668381_ChIP-Seq_PC3_Human1.25101327
63AR_25329375_ChIP-Seq_VCAP_Human1.25089311
64* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24621253
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23428648
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22951016
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22783647
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22036174
69* ARNT_22903824_ChIP-Seq_MCF-7_Human1.21880836
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20531550
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.20446325
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20076429
73CBP_20019798_ChIP-Seq_JUKART_Human1.19838465
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19838465
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18705436
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17454865
77WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17400151
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15161350
79* ZNF274_21170338_ChIP-Seq_K562_Hela1.14930939
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.14690685
81RUNX2_22187159_ChIP-Seq_PCA_Human1.12651586
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12547097
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11918333
84* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11243202
85* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11141230
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10926140
87* AHR_22903824_ChIP-Seq_MCF-7_Human1.10859037
88TCF4_22108803_ChIP-Seq_LS180_Human1.10786301
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08716878
90* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08704779
91BCAT_22108803_ChIP-Seq_LS180_Human1.08120345
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07372348
93* SMAD4_21741376_ChIP-Seq_EPCs_Human1.06866160
94TP53_22573176_ChIP-Seq_HFKS_Human1.06388266
95P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04798828
96* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04374071
97RNF2_27304074_Chip-Seq_NSC_Mouse1.04084444
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03785662
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03785662
100RING1B_27294783_Chip-Seq_ESCs_Mouse1.03754816
101TP53_16413492_ChIP-PET_HCT116_Human1.03367042
102BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03253949
103* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02328191
104* FOXA1_25329375_ChIP-Seq_VCAP_Human1.02328191
105SMAD3_21741376_ChIP-Seq_ESCs_Human1.01968326
106ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01754402
107* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01317171
108MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01045035
109* SMAD4_21741376_ChIP-Seq_HESCs_Human1.00822001
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00527316
111* GATA3_21878914_ChIP-Seq_MCF-7_Human1.00358094
112VDR_22108803_ChIP-Seq_LS180_Human0.99992999
113PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99235825
114* SMAD3_21741376_ChIP-Seq_HESCs_Human0.99188783
115* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98005502
116FUS_26573619_Chip-Seq_HEK293_Human0.97598866
117* NANOG_19829295_ChIP-Seq_ESCs_Human0.97597792
118* SOX2_19829295_ChIP-Seq_ESCs_Human0.97597792
119MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97136230
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97112409
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97077398
122ERG_21242973_ChIP-ChIP_JURKAT_Human0.97051282
123RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95090198
124BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95084611
125PRDM14_20953172_ChIP-Seq_ESCs_Human0.94310342
126E2F1_18555785_Chip-Seq_ESCs_Mouse0.94251595
127RING1B_27294783_Chip-Seq_NPCs_Mouse0.93946055

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.11115363
2MP0003635_abnormal_synaptic_transmissio3.53425785
3MP0003880_abnormal_central_pattern3.48728044
4MP0004270_analgesia3.37102202
5MP0009780_abnormal_chondrocyte_physiolo2.91554085
6MP0009745_abnormal_behavioral_response2.83098823
7MP0002063_abnormal_learning/memory/cond2.77529967
8MP0005423_abnormal_somatic_nervous2.76607608
9MP0002909_abnormal_adrenal_gland2.68085259
10MP0009046_muscle_twitch2.64673692
11MP0002064_seizures2.64572426
12MP0002572_abnormal_emotion/affect_behav2.47549826
13MP0003787_abnormal_imprinting2.47201230
14MP0002734_abnormal_mechanical_nocicepti2.32395387
15MP0002272_abnormal_nervous_system2.31521490
16MP0001486_abnormal_startle_reflex2.31426439
17MP0003646_muscle_fatigue2.31239663
18MP0010386_abnormal_urinary_bladder2.30993172
19MP0001501_abnormal_sleep_pattern2.28865748
20MP0001968_abnormal_touch/_nociception2.20485519
21MP0002102_abnormal_ear_morphology2.11992908
22MP0005646_abnormal_pituitary_gland2.04660685
23MP0005379_endocrine/exocrine_gland_phen2.00755253
24MP0008877_abnormal_DNA_methylation1.88005698
25MP0002822_catalepsy1.87017637
26MP0003122_maternal_imprinting1.84262474
27MP0002067_abnormal_sensory_capabilities1.83073273
28MP0003283_abnormal_digestive_organ1.80930620
29MP0005645_abnormal_hypothalamus_physiol1.79207907
30MP0000569_abnormal_digit_pigmentation1.79056647
31MP0002735_abnormal_chemical_nociception1.78696672
32MP0001440_abnormal_grooming_behavior1.78592061
33MP0002733_abnormal_thermal_nociception1.78150337
34MP0001984_abnormal_olfaction1.74705750
35MP0003183_abnormal_peptide_metabolism1.72910044
36MP0002557_abnormal_social/conspecific_i1.70822716
37MP0001970_abnormal_pain_threshold1.66588257
38MP0004043_abnormal_pH_regulation1.65273621
39MP0008569_lethality_at_weaning1.62429926
40MP0003011_delayed_dark_adaptation1.59485655
41* MP0002693_abnormal_pancreas_physiology1.59153154
42MP0008872_abnormal_physiological_respon1.54368186
43MP0002736_abnormal_nociception_after1.52191108
44* MP0002184_abnormal_innervation1.51983775
45MP0004133_heterotaxia1.51662920
46MP0001502_abnormal_circadian_rhythm1.49968924
47MP0004145_abnormal_muscle_electrophysio1.48576334
48MP0005551_abnormal_eye_electrophysiolog1.47373946
49MP0002653_abnormal_ependyma_morphology1.46808438
50MP0000778_abnormal_nervous_system1.46406292
51MP0006072_abnormal_retinal_apoptosis1.46233920
52MP0002638_abnormal_pupillary_reflex1.45815768
53MP0000013_abnormal_adipose_tissue1.43891333
54MP0008775_abnormal_heart_ventricle1.43465015
55MP0002160_abnormal_reproductive_system1.38981294
56* MP0001485_abnormal_pinna_reflex1.38447258
57MP0004130_abnormal_muscle_cell1.37962206
58MP0005386_behavior/neurological_phenoty1.35695518
59MP0004924_abnormal_behavior1.35695518
60MP0002938_white_spotting1.33177462
61MP0003136_yellow_coat_color1.31279602
62MP0006276_abnormal_autonomic_nervous1.30611235
63MP0003172_abnormal_lysosome_physiology1.29949798
64MP0000955_abnormal_spinal_cord1.29450508
65MP0004811_abnormal_neuron_physiology1.29442432
66* MP0001944_abnormal_pancreas_morphology1.29432920
67MP0001188_hyperpigmentation1.29339818
68MP0000427_abnormal_hair_cycle1.26570939
69MP0000230_abnormal_systemic_arterial1.25271433
70* MP0002882_abnormal_neuron_morphology1.24007029
71MP0004858_abnormal_nervous_system1.23501879
72* MP0003879_abnormal_hair_cell1.22536238
73MP0002876_abnormal_thyroid_physiology1.21174329
74MP0004215_abnormal_myocardial_fiber1.20707336
75MP0002928_abnormal_bile_duct1.20705473
76MP0003633_abnormal_nervous_system1.19537648
77MP0004019_abnormal_vitamin_homeostasis1.18640140
78MP0001986_abnormal_taste_sensitivity1.18623087
79MP0002066_abnormal_motor_capabilities/c1.17421167
80MP0002837_dystrophic_cardiac_calcinosis1.17245939
81MP0004885_abnormal_endolymph1.14946740
82MP0004142_abnormal_muscle_tone1.13119026
83MP0000631_abnormal_neuroendocrine_gland1.12803204
84MP0005174_abnormal_tail_pigmentation1.11773564
85MP0005448_abnormal_energy_balance1.09864133
86MP0005389_reproductive_system_phenotype1.09307451
87MP0000678_abnormal_parathyroid_gland1.04237768
88MP0005535_abnormal_body_temperature1.03102023
89MP0004510_myositis1.01798534
90* MP0002229_neurodegeneration1.01280490
91* MP0000026_abnormal_inner_ear1.01100853
92MP0003045_fibrosis1.00903026
93MP0008875_abnormal_xenobiotic_pharmacok1.00561730
94MP0000383_abnormal_hair_follicle0.98951126
95MP0006292_abnormal_olfactory_placode0.96936485
96MP0003890_abnormal_embryonic-extraembry0.96922109
97MP0003329_amyloid_beta_deposits0.94868477
98MP0005195_abnormal_posterior_eye0.94373312
99MP0002069_abnormal_eating/drinking_beha0.93863704
100MP0003938_abnormal_ear_development0.93310677
101MP0003119_abnormal_digestive_system0.92794530
102MP0002138_abnormal_hepatobiliary_system0.92360571
103MP0008961_abnormal_basal_metabolism0.91129305
104MP0003631_nervous_system_phenotype0.90845083
105MP0003878_abnormal_ear_physiology0.90094346
106MP0005377_hearing/vestibular/ear_phenot0.90094346
107MP0002152_abnormal_brain_morphology0.89962714
108MP0004742_abnormal_vestibular_system0.89640207
109MP0010329_abnormal_lipoprotein_level0.88368814
110* MP0004085_abnormal_heartbeat0.87036771
111MP0001905_abnormal_dopamine_level0.85287655
112* MP0002078_abnormal_glucose_homeostasis0.85092375
113MP0005253_abnormal_eye_physiology0.83571709
114MP0000049_abnormal_middle_ear0.82916251
115MP0002877_abnormal_melanocyte_morpholog0.82669624
116MP0002090_abnormal_vision0.79618447
117* MP0001765_abnormal_ion_homeostasis0.79222613
118MP0003634_abnormal_glial_cell0.79149920
119* MP0001963_abnormal_hearing_physiology0.77072776
120MP0002163_abnormal_gland_morphology0.76425401
121MP0005409_darkened_coat_color0.76282886
122MP0002234_abnormal_pharynx_morphology0.75697306
123MP0003195_calcinosis0.74734568
124MP0003121_genomic_imprinting0.74136267
125MP0001664_abnormal_digestion0.72560120
126MP0001177_atelectasis0.72127037
127MP0003690_abnormal_glial_cell0.70182051
128* MP0003953_abnormal_hormone_level0.69555436
129MP0005187_abnormal_penis_morphology0.69550470
130MP0005310_abnormal_salivary_gland0.64511676
131* MP0002752_abnormal_somatic_nervous0.63240599
132MP0001529_abnormal_vocalization0.62962476
133MP0001299_abnormal_eye_distance/0.62383276

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.98201305
2Visual hallucinations (HP:0002367)4.51629554
3Focal seizures (HP:0007359)4.50853343
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.41719847
5Epileptic encephalopathy (HP:0200134)4.37722500
6Pancreatic cysts (HP:0001737)4.00528174
7Febrile seizures (HP:0002373)3.93070441
8Progressive cerebellar ataxia (HP:0002073)3.89028602
9Molar tooth sign on MRI (HP:0002419)3.77175667
10Abnormality of midbrain morphology (HP:0002418)3.77175667
11Atonic seizures (HP:0010819)3.72519141
12Nephronophthisis (HP:0000090)3.64432301
13Pancreatic fibrosis (HP:0100732)3.63718627
14Myokymia (HP:0002411)3.61843385
15Congenital stationary night blindness (HP:0007642)3.60365757
16True hermaphroditism (HP:0010459)3.46848180
17Absence seizures (HP:0002121)3.42630839
18Abnormality of the renal cortex (HP:0011035)3.29232443
19Hyperinsulinemic hypoglycemia (HP:0000825)3.27245353
20Abolished electroretinogram (ERG) (HP:0000550)3.24710848
21Agitation (HP:0000713)3.21921729
22Abnormality of the renal medulla (HP:0100957)3.20665141
23Clumsiness (HP:0002312)3.19986846
24Dialeptic seizures (HP:0011146)3.19238587
25Epileptiform EEG discharges (HP:0011182)3.15479153
26EEG with generalized epileptiform discharges (HP:0011198)3.05054319
27Action tremor (HP:0002345)3.04936406
28Supranuclear gaze palsy (HP:0000605)3.00430746
29Abnormality of calcium-phosphate metabolism (HP:0100530)2.96190730
30Tubular atrophy (HP:0000092)2.94926759
31Gaze-evoked nystagmus (HP:0000640)2.93147003
32Broad-based gait (HP:0002136)2.92409183
33Excessive salivation (HP:0003781)2.90272606
34Drooling (HP:0002307)2.90272606
35Type II lissencephaly (HP:0007260)2.89511483
36* Generalized tonic-clonic seizures (HP:0002069)2.88018827
37Hyperventilation (HP:0002883)2.86408415
38Genetic anticipation (HP:0003743)2.85876078
39Hemiparesis (HP:0001269)2.84756116
40Hypsarrhythmia (HP:0002521)2.83797515
41Abnormal drinking behavior (HP:0030082)2.78854716
42Polydipsia (HP:0001959)2.78854716
43Cystic liver disease (HP:0006706)2.75966877
44Chronic hepatic failure (HP:0100626)2.70365412
45Truncal ataxia (HP:0002078)2.70148635
46Amblyopia (HP:0000646)2.66233773
47Decreased electroretinogram (ERG) amplitude (HP:0000654)2.64496438
48Hypoglycemic seizures (HP:0002173)2.61719641
49Retinal atrophy (HP:0001105)2.61177473
50Symptomatic seizures (HP:0011145)2.60919849
51Papilledema (HP:0001085)2.60113534
52Ankle clonus (HP:0011448)2.53595910
53Impaired smooth pursuit (HP:0007772)2.52744387
54Hyperkalemia (HP:0002153)2.52442973
55Attenuation of retinal blood vessels (HP:0007843)2.47723835
56Anxiety (HP:0000739)2.47573608
57Depression (HP:0000716)2.45368141
58Congenital sensorineural hearing impairment (HP:0008527)2.42356342
59Increased circulating renin level (HP:0000848)2.42227864
60Diplopia (HP:0000651)2.41797532
61Abnormality of binocular vision (HP:0011514)2.41797532
62Dysmetria (HP:0001310)2.37418494
63Inability to walk (HP:0002540)2.35817492
64Congenital, generalized hypertrichosis (HP:0004540)2.34248655
65Dysdiadochokinesis (HP:0002075)2.34246891
66Absent/shortened dynein arms (HP:0200106)2.30421306
67Dynein arm defect of respiratory motile cilia (HP:0012255)2.30421306
68Absent speech (HP:0001344)2.30331569
69Decreased central vision (HP:0007663)2.28814303
70Aplasia/Hypoplasia of the tibia (HP:0005772)2.28194016
71Abnormality of alanine metabolism (HP:0010916)2.27892407
72Hyperalaninemia (HP:0003348)2.27892407
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27892407
74Neurofibrillary tangles (HP:0002185)2.26060428
75Concave nail (HP:0001598)2.24298424
76* Decreased circulating renin level (HP:0003351)2.23643976
77Postural instability (HP:0002172)2.22364368
78Abnormal pancreas size (HP:0012094)2.21900523
79Hemiplegia (HP:0002301)2.20373001
80Abnormality of ocular smooth pursuit (HP:0000617)2.19797170
81Renal cortical cysts (HP:0000803)2.19100071
82Furrowed tongue (HP:0000221)2.18091404
83Abnormal rod and cone electroretinograms (HP:0008323)2.18088446
84Sclerocornea (HP:0000647)2.17245667
85Impaired vibration sensation in the lower limbs (HP:0002166)2.15040270
86Protruding tongue (HP:0010808)2.10605684
87Abnormality of salivation (HP:0100755)2.09856984
88Insulin-resistant diabetes mellitus (HP:0000831)2.09235425
89Keratoconus (HP:0000563)2.09007919
90Increased corneal curvature (HP:0100692)2.09007919
91Widely spaced teeth (HP:0000687)2.07603588
92Pancreatic islet-cell hyperplasia (HP:0004510)2.07009082
93Male pseudohermaphroditism (HP:0000037)2.06660167
94Prolonged QT interval (HP:0001657)2.06477684
95Polyuria (HP:0000103)2.06131333
96Bony spicule pigmentary retinopathy (HP:0007737)2.05713850
97Abnormal respiratory motile cilium morphology (HP:0005938)2.04914201
98Abnormal respiratory epithelium morphology (HP:0012253)2.04914201
99Abnormal ciliary motility (HP:0012262)2.04561985
100Cerebral inclusion bodies (HP:0100314)2.03786518
101Bilateral microphthalmos (HP:0007633)2.03199905
102Blue irides (HP:0000635)2.03107091
103Urinary bladder sphincter dysfunction (HP:0002839)2.02236883
104Poor eye contact (HP:0000817)2.01978487
105Ketosis (HP:0001946)2.01866973
106Patellar aplasia (HP:0006443)2.01424545
107Morphological abnormality of the middle ear (HP:0008609)2.00905382
108Aplasia/Hypoplasia of the patella (HP:0006498)1.99376325
109Nephrogenic diabetes insipidus (HP:0009806)1.98448061
110Abnormal eating behavior (HP:0100738)1.97197449
111Generalized hypopigmentation of hair (HP:0011358)1.95684639
112Congenital hepatic fibrosis (HP:0002612)1.95631082
113Pendular nystagmus (HP:0012043)1.95342239
114Genital tract atresia (HP:0001827)1.95029178
115Chorioretinal atrophy (HP:0000533)1.93866330
116Aplasia/hypoplasia of the uterus (HP:0008684)1.93428694
117Fibular aplasia (HP:0002990)1.92827482
118Gait imbalance (HP:0002141)1.92544190
119Tachypnea (HP:0002789)1.91579998
120Fibular hypoplasia (HP:0003038)1.91422033
121Vaginal atresia (HP:0000148)1.91373133
122Lissencephaly (HP:0001339)1.91288585
123Hypoplasia of the fovea (HP:0007750)1.90712244
124Aplasia/Hypoplasia of the fovea (HP:0008060)1.90712244
125Hypoplasia of the pons (HP:0012110)1.90409823
126Abnormal social behavior (HP:0012433)1.87879821
127Impaired social interactions (HP:0000735)1.87879821
128Abnormal EKG (HP:0003115)1.87459876
129Large for gestational age (HP:0001520)1.87230664
130Abnormality of the renal collecting system (HP:0004742)1.86276933
131Abnormality of the pons (HP:0007361)1.86222284
132Intention tremor (HP:0002080)1.85764672
133Abnormality of endocrine pancreas physiology (HP:0012093)1.84462823
134Abnormality of the pancreatic islet cells (HP:0006476)1.84462823
135Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83944775
136Hypothermia (HP:0002045)1.83714940
137Aplasia/Hypoplasia of the fibula (HP:0006492)1.83671596
138Abnormality of renal excretion (HP:0011036)1.83596187
139Progressive inability to walk (HP:0002505)1.81941644
140Spastic gait (HP:0002064)1.81709794
141Postural tremor (HP:0002174)1.81295522
142Stereotypic behavior (HP:0000733)1.81107276
143Bradykinesia (HP:0002067)1.80497927
144Hyperactive renin-angiotensin system (HP:0000841)1.80215963
145Exotropia (HP:0000577)1.79924412
146Psychosis (HP:0000709)1.79761706
147Syncope (HP:0001279)1.79573505
148Labial hypoplasia (HP:0000066)1.79566422
149Cerebellar dysplasia (HP:0007033)1.79215036
150Fair hair (HP:0002286)1.78744742
151Anencephaly (HP:0002323)1.77686788
152Methylmalonic acidemia (HP:0002912)1.77436631
153Ventricular fibrillation (HP:0001663)1.77032705
154Short tibia (HP:0005736)1.74490366
155Hyperglycemia (HP:0003074)1.74468643
156Limb dystonia (HP:0002451)1.74062935
157Abnormality of the nasal septum (HP:0000419)1.73892554
158Mesangial abnormality (HP:0001966)1.73032372
159Thyroid-stimulating hormone excess (HP:0002925)1.72884830
160Scanning speech (HP:0002168)1.72725339
161Mutism (HP:0002300)1.72611367
162Neuronal loss in central nervous system (HP:0002529)1.72385649
163Medial flaring of the eyebrow (HP:0010747)1.71605230
164Status epilepticus (HP:0002133)1.69875288
165Obstructive sleep apnea (HP:0002870)1.69826805
166Ketoacidosis (HP:0001993)1.69598704
167Macroorchidism (HP:0000053)1.68178997
168Gastroesophageal reflux (HP:0002020)1.66768583
169Lower limb muscle weakness (HP:0007340)1.65186173
170Intestinal atresia (HP:0011100)1.64361872
171Congenital primary aphakia (HP:0007707)1.64290834
172Megalencephaly (HP:0001355)1.64201487
173* Abnormality of potassium homeostasis (HP:0011042)1.63506598
174Neoplasm of the heart (HP:0100544)1.62476334
175Impaired vibratory sensation (HP:0002495)1.62110776

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.98433022
2INSRR3.50624981
3EPHA43.14690789
4ADRBK22.98096397
5MAP3K92.71154182
6TLK12.68164485
7ACVR1B2.62206944
8GRK12.55043156
9MAP3K42.41830737
10MARK12.35330977
11PRKD32.31770006
12PINK12.15213124
13MAP2K72.10891504
14CASK2.10378057
15TNIK1.95398579
16NTRK21.77656011
17TAOK31.76795472
18DAPK21.75304123
19RIPK41.71486219
20MINK11.67745204
21MAP3K21.63879377
22MAPK131.60852402
23MAP4K21.57947108
24SIK21.57428578
25PAK61.55734039
26FGFR21.49881374
27CDC42BPA1.48091663
28MAPK151.44651390
29STK391.43979811
30NTRK11.42081276
31CAMKK21.37688685
32OXSR11.37099468
33CAMKK11.32426275
34UHMK11.30913906
35PRPF4B1.30060281
36CDK51.27166520
37PIK3CA1.26043542
38NUAK11.24983723
39ZAK1.23800849
40WNK31.22786393
41ADRBK11.19277106
42CAMK1G1.18226774
43HIPK21.17522187
44PRKCH1.16256945
45MAP2K41.14365554
46SGK21.13305745
47FES1.13138929
48GRK51.12520741
49BMPR21.10561079
50KSR21.09982292
51PNCK1.08347751
52PRKCG1.07983755
53SGK4941.06810031
54SGK2231.06810031
55MAP3K131.04228587
56MAP2K61.04141437
57FRK1.01410821
58CAMK2A0.98657764
59KSR10.97946670
60STK380.97364104
61WNK10.95979480
62PLK20.95381604
63MAPKAPK30.94207985
64STK38L0.93266506
65SGK30.92589391
66PAK30.91517420
67SGK10.91252938
68MARK20.91227896
69AKT30.91124848
70CAMK2B0.87585433
71PRKCE0.87445178
72CAMK10.85219967
73MAP3K10.82333464
74WNK40.81460098
75TRPM70.81342158
76DYRK1A0.81174827
77NLK0.80956035
78DAPK10.80701399
79DYRK20.78372158
80BCR0.77658843
81TIE10.77188196
82STK110.76395403
83MAPKAPK50.75567220
84PRKD20.75353253
85ERBB20.75331300
86CAMK2D0.73712974
87NEK60.69017675
88PRKAA20.68756158
89MKNK20.67830568
90OBSCN0.66876123
91PHKG10.64497900
92PHKG20.64497900
93RPS6KA60.64225225
94CSNK1G20.63881435
95SIK30.63570456
96TGFBR10.62865731
97FER0.62656160
98PKN10.62529711
99PTK2B0.59785294
100PRKAA10.58700025
101CDK30.58542392
102RPS6KA20.58106955
103CSNK1G10.57523243
104STK30.57463622
105RPS6KA30.56924987
106BMPR1B0.56274847
107PRKG10.56149590
108RET0.55890627
109MUSK0.54379107
110GRK70.54167917
111CAMK40.52748493
112DMPK0.52215067
113TXK0.52185736
114TNK20.51743101
115CHUK0.51728856
116CSNK1A10.49915777
117PRKCZ0.49132985
118IRAK20.47718721
119CAMK1D0.47411179
120ARAF0.46082285
121PASK0.45818671
122PDPK10.44908710
123CSNK1G30.44781705
124PRKACA0.43981160
125FYN0.43693089
126MAP2K20.42459426
127MAPK100.41541597
128PRKCI0.41400214
129PRKCB0.41193921
130RPS6KA50.40880768
131MAP2K10.40231501
132PTK20.39923797
133EPHA30.39838570
134PDK10.38944102
135RPS6KB10.38787346
136NME10.37935336
137NEK20.37529308
138PRKCA0.37410971
139MAP3K70.37141929
140FGR0.37129391
141CAMK2G0.36681127
142IRAK10.34506413
143PRKCQ0.33632101

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.28820441
2* Insulin secretion_Homo sapiens_hsa049112.78261845
3* Circadian entrainment_Homo sapiens_hsa047132.56623431
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.47930583
5Synaptic vesicle cycle_Homo sapiens_hsa047212.47295465
6* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.46852644
7* GABAergic synapse_Homo sapiens_hsa047272.45317460
8Morphine addiction_Homo sapiens_hsa050322.38061489
9Long-term potentiation_Homo sapiens_hsa047202.37846077
10* Glutamatergic synapse_Homo sapiens_hsa047242.35759091
11Linoleic acid metabolism_Homo sapiens_hsa005912.31239368
12* Amphetamine addiction_Homo sapiens_hsa050312.26467555
13Olfactory transduction_Homo sapiens_hsa047402.24104938
14Taste transduction_Homo sapiens_hsa047422.21611180
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.16431698
16Nitrogen metabolism_Homo sapiens_hsa009102.14020306
17Tryptophan metabolism_Homo sapiens_hsa003802.01822523
18Butanoate metabolism_Homo sapiens_hsa006501.99325867
19Salivary secretion_Homo sapiens_hsa049701.95993290
20* Dopaminergic synapse_Homo sapiens_hsa047281.95487904
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.94270829
22Cocaine addiction_Homo sapiens_hsa050301.90378527
23* Type II diabetes mellitus_Homo sapiens_hsa049301.83998604
24* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80314370
25* Cholinergic synapse_Homo sapiens_hsa047251.78898908
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.77365631
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.75657788
28* Serotonergic synapse_Homo sapiens_hsa047261.71382426
29Gastric acid secretion_Homo sapiens_hsa049711.62167203
30* Renin secretion_Homo sapiens_hsa049241.60867266
31Long-term depression_Homo sapiens_hsa047301.58247229
32Selenocompound metabolism_Homo sapiens_hsa004501.50657939
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50542279
34* Calcium signaling pathway_Homo sapiens_hsa040201.49292056
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47854510
36Oxidative phosphorylation_Homo sapiens_hsa001901.46889907
37Ether lipid metabolism_Homo sapiens_hsa005651.45713269
38Caffeine metabolism_Homo sapiens_hsa002321.41422451
39* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38376585
40* Oxytocin signaling pathway_Homo sapiens_hsa049211.37688524
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.35757241
42Pancreatic secretion_Homo sapiens_hsa049721.34485872
43* cAMP signaling pathway_Homo sapiens_hsa040241.31710499
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.29541082
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26813156
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26688656
47Retinol metabolism_Homo sapiens_hsa008301.25732013
48Type I diabetes mellitus_Homo sapiens_hsa049401.25029838
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24650627
50* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19297268
51Estrogen signaling pathway_Homo sapiens_hsa049151.16499704
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15687566
53Collecting duct acid secretion_Homo sapiens_hsa049661.15431844
54Primary bile acid biosynthesis_Homo sapiens_hsa001201.15332734
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15097441
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14484415
57Chemical carcinogenesis_Homo sapiens_hsa052041.14396561
58* GnRH signaling pathway_Homo sapiens_hsa049121.11629878
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11524933
60Histidine metabolism_Homo sapiens_hsa003401.10752352
61Vitamin digestion and absorption_Homo sapiens_hsa049771.10059527
62Phototransduction_Homo sapiens_hsa047441.09971365
63Vibrio cholerae infection_Homo sapiens_hsa051101.09599136
64Sulfur metabolism_Homo sapiens_hsa009201.06177754
65* Vascular smooth muscle contraction_Homo sapiens_hsa042701.03930724
66Circadian rhythm_Homo sapiens_hsa047101.03382718
67* Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03020641
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01624718
69Gap junction_Homo sapiens_hsa045401.01237035
70Thyroid hormone synthesis_Homo sapiens_hsa049181.00540626
71Glycerolipid metabolism_Homo sapiens_hsa005610.96814048
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94875839
73Peroxisome_Homo sapiens_hsa041460.92605512
74Melanogenesis_Homo sapiens_hsa049160.92041161
75Parkinsons disease_Homo sapiens_hsa050120.91284405
76Arachidonic acid metabolism_Homo sapiens_hsa005900.88989882
77Dorso-ventral axis formation_Homo sapiens_hsa043200.88184181
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87549717
79beta-Alanine metabolism_Homo sapiens_hsa004100.82820284
80Glucagon signaling pathway_Homo sapiens_hsa049220.81367761
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80586923
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80142516
83Axon guidance_Homo sapiens_hsa043600.79729663
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76828822
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76595268
86ErbB signaling pathway_Homo sapiens_hsa040120.74795954
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.73793588
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73209775
89Glioma_Homo sapiens_hsa052140.71689266
90Inositol phosphate metabolism_Homo sapiens_hsa005620.70807995
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.67477204
92Alzheimers disease_Homo sapiens_hsa050100.67033584
93* Dilated cardiomyopathy_Homo sapiens_hsa054140.66994036
94Fat digestion and absorption_Homo sapiens_hsa049750.66080152
95Huntingtons disease_Homo sapiens_hsa050160.64788716
96Choline metabolism in cancer_Homo sapiens_hsa052310.64337172
97* MAPK signaling pathway_Homo sapiens_hsa040100.63196120
98Regulation of autophagy_Homo sapiens_hsa041400.62680692
99* Cardiac muscle contraction_Homo sapiens_hsa042600.59750836
100Basal transcription factors_Homo sapiens_hsa030220.59650169
101Ovarian steroidogenesis_Homo sapiens_hsa049130.57393044
102Hedgehog signaling pathway_Homo sapiens_hsa043400.57002867
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56193843
104Prion diseases_Homo sapiens_hsa050200.56171611
105Ras signaling pathway_Homo sapiens_hsa040140.55991092
106Fatty acid biosynthesis_Homo sapiens_hsa000610.55383686
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54019371
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53405662
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53161581
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52717319
111Protein export_Homo sapiens_hsa030600.51124994
112Basal cell carcinoma_Homo sapiens_hsa052170.51017864
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50361965
114mTOR signaling pathway_Homo sapiens_hsa041500.49012360
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48946400
116Lysosome_Homo sapiens_hsa041420.48574106
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48205334
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45935347
119Propanoate metabolism_Homo sapiens_hsa006400.44995974
120Wnt signaling pathway_Homo sapiens_hsa043100.44335413
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.44221131
122Rap1 signaling pathway_Homo sapiens_hsa040150.43785249
123African trypanosomiasis_Homo sapiens_hsa051430.43640551
124Chemokine signaling pathway_Homo sapiens_hsa040620.43603657
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43525893
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.42525153
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42040639
128Alcoholism_Homo sapiens_hsa050340.40679986
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38469138
130Bile secretion_Homo sapiens_hsa049760.37229268
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.36552857
132Prolactin signaling pathway_Homo sapiens_hsa049170.35411206
133Insulin signaling pathway_Homo sapiens_hsa049100.35270226
134Renal cell carcinoma_Homo sapiens_hsa052110.35094149
135* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34388679
136Homologous recombination_Homo sapiens_hsa034400.34101719
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33578837
138RNA polymerase_Homo sapiens_hsa030200.33241366
139Insulin resistance_Homo sapiens_hsa049310.32740858
140Metabolic pathways_Homo sapiens_hsa011000.32702861
141Oocyte meiosis_Homo sapiens_hsa041140.32157709
142Fatty acid degradation_Homo sapiens_hsa000710.31860575
143Sphingolipid metabolism_Homo sapiens_hsa006000.30274285
144Mineral absorption_Homo sapiens_hsa049780.30165525
145Glycosaminoglycan degradation_Homo sapiens_hsa005310.30106854
146* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29565316
147Endocytosis_Homo sapiens_hsa041440.29401690
148Endometrial cancer_Homo sapiens_hsa052130.28914277
149ABC transporters_Homo sapiens_hsa020100.27530639

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