CACNA1F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multipass transmembrane protein that functions as an alpha-1 subunit of the voltage-dependent calcium channel, which mediates the influx of calcium ions into the cell. The encoded protein forms a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Mutations in this gene can cause X-linked eye disorders, including congenital stationary night blindness type 2A, cone-rod dystropy, and Aland Island eye disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1photoreceptor cell development (GO:0042461)8.88745947
2eye photoreceptor cell development (GO:0042462)8.65959505
3photoreceptor cell maintenance (GO:0045494)8.54331605
4response to pheromone (GO:0019236)7.63381049
5negative regulation of cytosolic calcium ion concentration (GO:0051481)6.40370204
6* detection of light stimulus (GO:0009583)6.39243783
7* detection of visible light (GO:0009584)6.37435201
8* visual perception (GO:0007601)6.20800964
9protein-chromophore linkage (GO:0018298)6.17619774
10* sensory perception of light stimulus (GO:0050953)6.16855751
11regulation of protein kinase A signaling (GO:0010738)6.13867900
12phototransduction (GO:0007602)6.10342163
13cellular potassium ion homeostasis (GO:0030007)6.07141702
14GMP metabolic process (GO:0046037)5.98895718
15phototransduction, visible light (GO:0007603)5.96965081
16regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.74963706
17potassium ion homeostasis (GO:0055075)5.53942615
18cAMP catabolic process (GO:0006198)5.50220065
19sodium ion export (GO:0071436)5.34067368
20L-fucose catabolic process (GO:0042355)5.30429147
21fucose catabolic process (GO:0019317)5.30429147
22L-fucose metabolic process (GO:0042354)5.30429147
23G-protein coupled glutamate receptor signaling pathway (GO:0007216)5.28062954
24cyclic nucleotide catabolic process (GO:0009214)5.25613794
25cellular response to light stimulus (GO:0071482)5.04076714
26eye photoreceptor cell differentiation (GO:0001754)4.90787425
27photoreceptor cell differentiation (GO:0046530)4.90787425
28nonmotile primary cilium assembly (GO:0035058)4.89017123
29establishment of protein localization to Golgi (GO:0072600)4.79650948
30positive regulation of guanylate cyclase activity (GO:0031284)4.76821671
31synaptic vesicle exocytosis (GO:0016079)4.67524655
32striatum development (GO:0021756)4.59365341
33* detection of external stimulus (GO:0009581)4.59040856
34* detection of abiotic stimulus (GO:0009582)4.51943980
35* retina development in camera-type eye (GO:0060041)4.51231932
36synaptic vesicle endocytosis (GO:0048488)4.44686073
37mating behavior (GO:0007617)4.44681842
38positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.44390117
39positive regulation of synapse maturation (GO:0090129)4.43857472
40regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.43826402
41regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.43826402
42regulation of cGMP metabolic process (GO:0030823)4.42809347
43protein targeting to Golgi (GO:0000042)4.41218205
44regulation of short-term neuronal synaptic plasticity (GO:0048172)4.33361181
45innervation (GO:0060384)4.28148274
46positive regulation of cGMP biosynthetic process (GO:0030828)4.27727327
47regulation of guanylate cyclase activity (GO:0031282)4.24521422
48protein localization to synapse (GO:0035418)4.24196848
49regulation of voltage-gated calcium channel activity (GO:1901385)4.19752186
50protein localization to Golgi apparatus (GO:0034067)4.19728417
51peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.19520421
52behavioral response to nicotine (GO:0035095)4.19443395
53DNA deamination (GO:0045006)4.12701743
54relaxation of smooth muscle (GO:0044557)4.10726194
55membrane hyperpolarization (GO:0060081)4.09768433
56proline transport (GO:0015824)4.07037605
57regulation of synaptic vesicle exocytosis (GO:2000300)4.05585745
58synaptic vesicle maturation (GO:0016188)4.04746232
59protein polyglutamylation (GO:0018095)4.04486048
60regulation of cGMP biosynthetic process (GO:0030826)3.98493528
61retrograde transport, vesicle recycling within Golgi (GO:0000301)3.96761842
62cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.96232672
63gamma-aminobutyric acid signaling pathway (GO:0007214)3.93430772
64regulation of cAMP-mediated signaling (GO:0043949)3.89141510
65regulation of cilium movement (GO:0003352)3.86983275
66meiotic chromosome segregation (GO:0045132)3.85289918
67positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.72031699
68alanine transport (GO:0032328)3.71961340
69positive regulation of cGMP metabolic process (GO:0030825)3.71213528
70negative regulation of cAMP-mediated signaling (GO:0043951)3.70835453
71potassium ion export (GO:0071435)3.61679048
72response to histamine (GO:0034776)3.55631774
73multicellular organism reproduction (GO:0032504)3.55224784
74positive regulation of sodium ion transmembrane transport (GO:1902307)3.43830047
75regulation of synapse maturation (GO:0090128)3.41992964
76indolalkylamine metabolic process (GO:0006586)3.39594534
77cellular sodium ion homeostasis (GO:0006883)3.38868552
78acrosome assembly (GO:0001675)3.37525598
79piRNA metabolic process (GO:0034587)3.37167917
80behavioral response to cocaine (GO:0048148)3.35556668
81indole-containing compound catabolic process (GO:0042436)3.33783190
82indolalkylamine catabolic process (GO:0046218)3.33783190
83tryptophan catabolic process (GO:0006569)3.33783190
84substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.32271028
85substrate-independent telencephalic tangential migration (GO:0021826)3.32271028
86synaptic vesicle docking involved in exocytosis (GO:0016081)3.30413861
87cell communication by electrical coupling (GO:0010644)3.28762757
88synaptic transmission, dopaminergic (GO:0001963)3.27032742
89regulation of synaptic vesicle transport (GO:1902803)3.26440633
90urinary tract smooth muscle contraction (GO:0014848)3.22567803
91regulation of neurotransmitter uptake (GO:0051580)3.18117344
92axoneme assembly (GO:0035082)3.17182250
93regulation of hexokinase activity (GO:1903299)3.16542136
94regulation of glucokinase activity (GO:0033131)3.16542136
95prepulse inhibition (GO:0060134)3.15767525
96preassembly of GPI anchor in ER membrane (GO:0016254)3.13646803
97auditory receptor cell stereocilium organization (GO:0060088)3.11883677
98cGMP metabolic process (GO:0046068)3.11085792
99protein localization to cilium (GO:0061512)3.10746827
100neuron development (GO:0048666)3.09635334
101nephron tubule morphogenesis (GO:0072078)3.08095617
102nephron epithelium morphogenesis (GO:0072088)3.08095617
103cellular ketone body metabolic process (GO:0046950)3.07964152
104cellular response to radiation (GO:0071478)3.07613424
105behavioral response to ethanol (GO:0048149)3.05967744
106* sensory perception (GO:0007600)3.05299325
107cytidine deamination (GO:0009972)3.04305631
108cytidine metabolic process (GO:0046087)3.04305631
109cytidine catabolic process (GO:0006216)3.04305631
110lactate metabolic process (GO:0006089)3.04018439
111positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.03878343
112sperm motility (GO:0030317)3.03388964
113kynurenine metabolic process (GO:0070189)3.03227222
114regulation of neurotransmitter secretion (GO:0046928)3.02233361
115glycine transport (GO:0015816)3.00899197
116positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.99636126
117organic cation transport (GO:0015695)2.98162237
118somite rostral/caudal axis specification (GO:0032525)2.98057126
119DNA double-strand break processing (GO:0000729)2.93936412
120glycolytic process (GO:0006096)2.93520930
121synaptic vesicle transport (GO:0048489)2.93252239
122establishment of synaptic vesicle localization (GO:0097480)2.93252239
123atrial cardiac muscle cell action potential (GO:0086014)2.92818442
124positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.90902936
125cellular potassium ion transport (GO:0071804)2.90426893
126potassium ion transmembrane transport (GO:0071805)2.90426893
127positive regulation of defense response to virus by host (GO:0002230)2.89173597
128DNA methylation involved in gamete generation (GO:0043046)2.87877176
129peristalsis (GO:0030432)2.87317440
130regulation of dopamine metabolic process (GO:0042053)2.86846338
131regulation of catecholamine metabolic process (GO:0042069)2.86846338
132regulation of neurotransmitter transport (GO:0051588)2.86304421
133ketone body metabolic process (GO:1902224)2.84609840
134fucosylation (GO:0036065)2.83567186
135tryptophan metabolic process (GO:0006568)2.83560329
136detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.83461942
137regulation of type B pancreatic cell apoptotic process (GO:2000674)2.82488217
138protein K11-linked deubiquitination (GO:0035871)2.81334335
139regulation of microtubule-based movement (GO:0060632)2.78573957
140glutamate secretion (GO:0014047)2.77764444
141long term synaptic depression (GO:0060292)2.77185595
142regulation of bile acid biosynthetic process (GO:0070857)2.76497853
143regulation of transforming growth factor beta2 production (GO:0032909)2.75017480
144potassium ion import (GO:0010107)2.74631846
145respiratory chain complex IV assembly (GO:0008535)2.74619515
146* response to light stimulus (GO:0009416)2.74444215
147pyrimidine ribonucleoside catabolic process (GO:0046133)2.73971591
148dentate gyrus development (GO:0021542)2.73706377
149coenzyme catabolic process (GO:0009109)2.72182565
150cGMP biosynthetic process (GO:0006182)2.71776274
151sphingosine metabolic process (GO:0006670)2.71760964
152regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)2.70675292
153inositol phosphate catabolic process (GO:0071545)2.64340400
154amine catabolic process (GO:0009310)2.62558307
155cellular biogenic amine catabolic process (GO:0042402)2.62558307
156epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.61814638
157adenosine metabolic process (GO:0046085)2.61753495
158negative regulation of mast cell activation (GO:0033004)2.61177878
159cilium organization (GO:0044782)2.60632069
160adaptation of signaling pathway (GO:0023058)2.60542115
161cellular response to sterol (GO:0036315)2.60100016
162phosphorylated carbohydrate dephosphorylation (GO:0046838)2.59365323
163inositol phosphate dephosphorylation (GO:0046855)2.59365323
164inner ear receptor stereocilium organization (GO:0060122)2.58122875
165epithelial cilium movement (GO:0003351)2.57623248
166diol metabolic process (GO:0034311)2.56381418
167histone H3-K4 trimethylation (GO:0080182)2.55629300
168GPI anchor metabolic process (GO:0006505)2.53964079
169cellular response to ATP (GO:0071318)2.52354679
170cilium assembly (GO:0042384)2.52099078
171sphingoid metabolic process (GO:0046519)2.51291508
172C4-dicarboxylate transport (GO:0015740)2.50801219
173neural tube formation (GO:0001841)2.50289168
174regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.49772983
175water-soluble vitamin biosynthetic process (GO:0042364)2.49537826
176neuronal action potential (GO:0019228)2.48620410
177regulation of action potential (GO:0098900)2.47906273
178cilium morphogenesis (GO:0060271)2.47835814
179dopamine transport (GO:0015872)2.46111319
180reflex (GO:0060004)2.41969903
181cornea development in camera-type eye (GO:0061303)2.41798830
182indole-containing compound metabolic process (GO:0042430)2.40034563
183* detection of light stimulus involved in visual perception (GO:0050908)11.2484050
184* detection of light stimulus involved in sensory perception (GO:0050962)11.2484050
185rhodopsin mediated signaling pathway (GO:0016056)10.6581364
186regulation of rhodopsin mediated signaling pathway (GO:0022400)10.5993731
187retinal rod cell development (GO:0046548)10.4741689
188retinal cone cell development (GO:0046549)10.2847572

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.01119791
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.69113870
3GBX2_23144817_ChIP-Seq_PC3_Human3.67192331
4ZNF274_21170338_ChIP-Seq_K562_Hela3.60003188
5DROSHA_22980978_ChIP-Seq_HELA_Human2.86718901
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.62327153
7REST_21632747_ChIP-Seq_MESCs_Mouse2.60180919
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.60112494
9EZH2_22144423_ChIP-Seq_EOC_Human2.59003646
10AR_21572438_ChIP-Seq_LNCaP_Human2.43041082
11EZH2_27294783_Chip-Seq_ESCs_Mouse2.36803012
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.33326421
13P53_22127205_ChIP-Seq_FIBROBLAST_Human2.30905875
14SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27761961
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.27023487
16* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.25648598
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.19782355
18IGF1R_20145208_ChIP-Seq_DFB_Human2.18439585
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.14712075
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.10091441
21* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse2.09367169
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.08939497
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.04802030
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.00762564
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.99861713
26MTF2_20144788_ChIP-Seq_MESCs_Mouse1.97521268
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.95563279
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.92916326
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.89216650
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.87900982
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.81069961
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78983749
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.78072022
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.78072022
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76725848
36IRF1_19129219_ChIP-ChIP_H3396_Human1.73702781
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72830408
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72122065
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71558302
40TP53_22573176_ChIP-Seq_HFKS_Human1.70935941
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66061159
42RARB_27405468_Chip-Seq_BRAIN_Mouse1.65352034
43EWS_26573619_Chip-Seq_HEK293_Human1.64545091
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63622426
45SMAD4_21799915_ChIP-Seq_A2780_Human1.60957364
46DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.58003320
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51278296
48GATA3_21878914_ChIP-Seq_MCF-7_Human1.49495666
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48989171
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.48584366
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.47584125
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47450155
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.47293017
54AR_19668381_ChIP-Seq_PC3_Human1.47280372
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47077187
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46588424
57FOXA1_21572438_ChIP-Seq_LNCaP_Human1.46171486
58SMAD3_21741376_ChIP-Seq_HESCs_Human1.44173980
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.42548672
60TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.41645464
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41521814
62FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.39856585
63ELK4_26923725_Chip-Seq_MESODERM_Mouse1.39387406
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38663585
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38477605
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37534173
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.33784137
68FUS_26573619_Chip-Seq_HEK293_Human1.33254565
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.31950419
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.31302671
71NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.29862861
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29559126
73HOXB7_26014856_ChIP-Seq_BT474_Human1.28765671
74SOX2_19829295_ChIP-Seq_ESCs_Human1.27344569
75NANOG_19829295_ChIP-Seq_ESCs_Human1.27344569
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26518849
77TCF4_22108803_ChIP-Seq_LS180_Human1.26377982
78CBP_20019798_ChIP-Seq_JUKART_Human1.25832800
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25832800
80ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25503786
81FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24376695
82FOXA1_25329375_ChIP-Seq_VCAP_Human1.24376695
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23374913
84PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.22116519
85CTCF_27219007_Chip-Seq_Bcells_Human1.22082785
86RING1B_27294783_Chip-Seq_NPCs_Mouse1.21670763
87RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21559735
88AR_25329375_ChIP-Seq_VCAP_Human1.19917822
89RING1B_27294783_Chip-Seq_ESCs_Mouse1.19306113
90STAT3_23295773_ChIP-Seq_U87_Human1.19178929
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18834625
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16768959
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16768959
94RUNX2_22187159_ChIP-Seq_PCA_Human1.15427062
95MYC_19829295_ChIP-Seq_ESCs_Human1.15425625
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15234546
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15094968
98SMAD4_21741376_ChIP-Seq_EPCs_Human1.14954296
99FLI1_21867929_ChIP-Seq_TH2_Mouse1.14651808
100TCF4_23295773_ChIP-Seq_U87_Human1.14014030
101ERA_21632823_ChIP-Seq_H3396_Human1.13714423
102TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.13292745
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13018383
104RNF2_27304074_Chip-Seq_NSC_Mouse1.12514213
105NFE2_27457419_Chip-Seq_LIVER_Mouse1.11813557
106NCOR_22424771_ChIP-Seq_293T_Human1.11432078
107YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11126458
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10095180
109SOX2_21211035_ChIP-Seq_LN229_Gbm1.09932037
110GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.09348255
111SMAD4_21741376_ChIP-Seq_HESCs_Human1.09206837
112TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08705165
113NANOG_20526341_ChIP-Seq_ESCs_Human1.07840886
114P300_19829295_ChIP-Seq_ESCs_Human1.07201368
115PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07080339
116BCAT_22108803_ChIP-Seq_LS180_Human1.06606215
117AR_20517297_ChIP-Seq_VCAP_Human1.05177882
118SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04218447
119CBP_21632823_ChIP-Seq_H3396_Human1.03813941
120EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03635330
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03350710
122AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02996234
123TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02010886
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01850025
125SMAD3_21741376_ChIP-Seq_EPCs_Human1.01720745
126TAF2_19829295_ChIP-Seq_ESCs_Human1.01309171
127EZH2_27294783_Chip-Seq_NPCs_Mouse1.01266013
128TAF15_26573619_Chip-Seq_HEK293_Human1.00800201
129IRF8_22096565_ChIP-ChIP_GC-B_Human1.00301224
130P53_21459846_ChIP-Seq_SAOS-2_Human0.99906114
131CDX2_22108803_ChIP-Seq_LS180_Human0.99497347
132VDR_22108803_ChIP-Seq_LS180_Human0.98796900
133SMAD_19615063_ChIP-ChIP_OVARY_Human0.98719374
134UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98448165
135KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98403901
136TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97415388
137DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97194507
138FOXH1_21741376_ChIP-Seq_ESCs_Human0.96997613
139TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96951628
140CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96890911
141EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96860974
142TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.96599178
143SMRT_27268052_Chip-Seq_Bcells_Human0.96148279
144EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95851690
145TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95626408
146RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95616330
147PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95404727
148CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94895689
149NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94757434
150E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.94704711
151STAT3_18555785_Chip-Seq_ESCs_Mouse0.93766301
152PRDM14_20953172_ChIP-Seq_ESCs_Human0.93571258
153P53_22387025_ChIP-Seq_ESCs_Mouse0.93287681
154EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93118080
155ER_23166858_ChIP-Seq_MCF-7_Human0.92697540
156SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.92681114
157BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91412454
158KDM2B_26808549_Chip-Seq_K562_Human0.90794458
159OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90284374
160WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88406123
161TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88104692
162SOX9_26525672_Chip-Seq_HEART_Mouse0.87589596
163SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87401703

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog8.98479082
2MP0003011_delayed_dark_adaptation6.92540531
3MP0006072_abnormal_retinal_apoptosis6.23722861
4MP0005253_abnormal_eye_physiology5.59051573
5MP0002090_abnormal_vision4.53525611
6MP0003950_abnormal_plasma_membrane4.00583265
7* MP0005195_abnormal_posterior_eye3.56743777
8MP0001984_abnormal_olfaction2.92858316
9MP0002638_abnormal_pupillary_reflex2.89288654
10MP0001324_abnormal_eye_pigmentation2.88504951
11MP0003195_calcinosis2.81059867
12MP0001502_abnormal_circadian_rhythm2.78820467
13MP0004233_abnormal_muscle_weight2.70048334
14MP0003136_yellow_coat_color2.66100110
15MP0005391_vision/eye_phenotype2.56925547
16MP0002837_dystrophic_cardiac_calcinosis2.53040625
17MP0002229_neurodegeneration2.45929455
18MP0008877_abnormal_DNA_methylation2.38912976
19MP0005423_abnormal_somatic_nervous2.19336428
20MP0006292_abnormal_olfactory_placode2.14066640
21MP0002138_abnormal_hepatobiliary_system2.12336534
22MP0002876_abnormal_thyroid_physiology1.99118936
23MP0000372_irregular_coat_pigmentation1.97834420
24MP0005248_abnormal_Harderian_gland1.93455533
25MP0004782_abnormal_surfactant_physiolog1.87147410
26* MP0002752_abnormal_somatic_nervous1.86086184
27MP0005174_abnormal_tail_pigmentation1.84926507
28MP0002102_abnormal_ear_morphology1.82492853
29MP0001346_abnormal_lacrimal_gland1.74954702
30MP0008872_abnormal_physiological_respon1.68286581
31MP0001486_abnormal_startle_reflex1.59028452
32MP0005646_abnormal_pituitary_gland1.57394002
33MP0005377_hearing/vestibular/ear_phenot1.55866309
34MP0003878_abnormal_ear_physiology1.55866309
35MP0006276_abnormal_autonomic_nervous1.52786554
36MP0005379_endocrine/exocrine_gland_phen1.52081209
37MP0005499_abnormal_olfactory_system1.50834954
38MP0005394_taste/olfaction_phenotype1.50834954
39MP0004133_heterotaxia1.48906971
40MP0008789_abnormal_olfactory_epithelium1.42385744
41MP0002163_abnormal_gland_morphology1.41512381
42* MP0002882_abnormal_neuron_morphology1.41167518
43MP0002332_abnormal_exercise_endurance1.41121942
44MP0008875_abnormal_xenobiotic_pharmacok1.40891546
45MP0005410_abnormal_fertilization1.38946281
46MP0002653_abnormal_ependyma_morphology1.37714594
47MP0004147_increased_porphyrin_level1.37597682
48MP0003880_abnormal_central_pattern1.34511725
49MP0002272_abnormal_nervous_system1.32185117
50MP0002733_abnormal_thermal_nociception1.32117183
51MP0005075_abnormal_melanosome_morpholog1.31614374
52MP0010386_abnormal_urinary_bladder1.30491530
53MP0002693_abnormal_pancreas_physiology1.30261419
54MP0005645_abnormal_hypothalamus_physiol1.29500340
55MP0004215_abnormal_myocardial_fiber1.28969252
56MP0009046_muscle_twitch1.24998746
57MP0003635_abnormal_synaptic_transmissio1.23607994
58MP0003646_muscle_fatigue1.23141937
59MP0002064_seizures1.21377291
60MP0002928_abnormal_bile_duct1.20295203
61MP0000015_abnormal_ear_pigmentation1.19158821
62MP0003786_premature_aging1.17462533
63MP0001485_abnormal_pinna_reflex1.16912682
64MP0008995_early_reproductive_senescence1.16736971
65MP0006036_abnormal_mitochondrial_physio1.16446399
66MP0001905_abnormal_dopamine_level1.13424613
67MP0004484_altered_response_of1.10835508
68MP0004145_abnormal_muscle_electrophysio1.09816649
69MP0001764_abnormal_homeostasis1.09474278
70MP0003718_maternal_effect1.09155921
71MP0002067_abnormal_sensory_capabilities1.07212283
72MP0004381_abnormal_hair_follicle1.04841171
73MP0001986_abnormal_taste_sensitivity1.04658798
74MP0002063_abnormal_learning/memory/cond1.02496797
75MP0002734_abnormal_mechanical_nocicepti1.01125482
76MP0008775_abnormal_heart_ventricle0.99575423
77MP0001765_abnormal_ion_homeostasis0.98110148
78MP0005595_abnormal_vascular_smooth0.97639691
79MP0003698_abnormal_male_reproductive0.96771296
80MP0003634_abnormal_glial_cell0.94182569
81MP0005670_abnormal_white_adipose0.91810546
82MP0000631_abnormal_neuroendocrine_gland0.90992440
83MP0004859_abnormal_synaptic_plasticity0.90975755
84MP0002735_abnormal_chemical_nociception0.90909922
85MP0004019_abnormal_vitamin_homeostasis0.90886511
86MP0009745_abnormal_behavioral_response0.90191498
87MP0003122_maternal_imprinting0.88617230
88MP0010368_abnormal_lymphatic_system0.87574683
89MP0004036_abnormal_muscle_relaxation0.86263916
90MP0004043_abnormal_pH_regulation0.86178010
91MP0005084_abnormal_gallbladder_morpholo0.86027058
92MP0005671_abnormal_response_to0.85905786
93MP0002572_abnormal_emotion/affect_behav0.85633973
94MP0000371_diluted_coat_color0.85514879
95MP0006035_abnormal_mitochondrial_morpho0.84907204
96MP0005332_abnormal_amino_acid0.84586531
97MP0003787_abnormal_imprinting0.83238757
98MP0003183_abnormal_peptide_metabolism0.81757195
99MP0001968_abnormal_touch/_nociception0.81295540
100MP0002938_white_spotting0.81133047
101MP0010030_abnormal_orbit_morphology0.80967035
102MP0000230_abnormal_systemic_arterial0.80402324
103MP0008058_abnormal_DNA_repair0.79788812
104MP0001188_hyperpigmentation0.79515726
105MP0001873_stomach_inflammation0.77709031
106MP0002254_reproductive_system_inflammat0.76145088
107MP0000383_abnormal_hair_follicle0.75165340
108MP0004742_abnormal_vestibular_system0.72948779
109MP0001944_abnormal_pancreas_morphology0.72206370
110MP0008569_lethality_at_weaning0.72109064
111MP0005636_abnormal_mineral_homeostasis0.71782809
112* MP0002184_abnormal_innervation0.69555938
113MP0004084_abnormal_cardiac_muscle0.69465854
114MP0004270_analgesia0.67643276
115MP0002127_abnormal_cardiovascular_syste0.64945156
116MP0003879_abnormal_hair_cell0.63342053
117MP0000751_myopathy0.61549009
118MP0003045_fibrosis0.61504165
119MP0005197_abnormal_uvea_morphology0.58979282
120MP0004142_abnormal_muscle_tone0.57503613
121MP0003137_abnormal_impulse_conducting0.56517347
122MP0001963_abnormal_hearing_physiology0.54678485
123MP0002557_abnormal_social/conspecific_i0.54121250
124MP0004924_abnormal_behavior0.53703668
125MP0005386_behavior/neurological_phenoty0.53703668
126MP0003172_abnormal_lysosome_physiology0.52900266
127MP0004811_abnormal_neuron_physiology0.52581490
128MP0001501_abnormal_sleep_pattern0.52255381
129MP0003633_abnormal_nervous_system0.52082378
130MP0002909_abnormal_adrenal_gland0.51999743
131MP0004085_abnormal_heartbeat0.51512878
132MP0002697_abnormal_eye_size0.49848979
133MP0004885_abnormal_endolymph0.49496951
134MP0005620_abnormal_muscle_contractility0.48082446
135MP0002152_abnormal_brain_morphology0.47564174
136MP0002066_abnormal_motor_capabilities/c0.47468706
137MP0000955_abnormal_spinal_cord0.46736198
138MP0005220_abnormal_exocrine_pancreas0.46396720
139MP0002089_abnormal_postnatal_growth/wei0.46212502
140MP0000569_abnormal_digit_pigmentation0.44896801
141MP0001529_abnormal_vocalization0.44326818
142MP0002234_abnormal_pharynx_morphology0.43165939
143MP0002069_abnormal_eating/drinking_beha0.42951746
144MP0008004_abnormal_stomach_pH0.39294063
145MP0001970_abnormal_pain_threshold0.38870677
146MP0001286_abnormal_eye_development0.38775862
147MP0001661_extended_life_span0.35351764
148MP0002736_abnormal_nociception_after0.34221297
149MP0000465_gastrointestinal_hemorrhage0.34052304
150MP0003890_abnormal_embryonic-extraembry0.33043896
151MP0003631_nervous_system_phenotype0.32737259
152MP0000026_abnormal_inner_ear0.31837913
153MP0008260_abnormal_autophagy0.31161803
154MP0002108_abnormal_muscle_morphology0.30287189

Predicted human phenotypes

RankGene SetZ-score
1Bony spicule pigmentary retinopathy (HP:0007737)9.91344835
2* Abnormal rod and cone electroretinograms (HP:0008323)8.66152940
3Absent rod-and cone-mediated responses on ERG (HP:0007688)8.64813986
4Decreased central vision (HP:0007663)7.23422259
5Pendular nystagmus (HP:0012043)7.17967538
6* Central scotoma (HP:0000603)6.85376474
7Chorioretinal atrophy (HP:0000533)6.69801903
8Attenuation of retinal blood vessels (HP:0007843)6.64180899
9* Abnormality of macular pigmentation (HP:0008002)6.56583184
10Pigmentary retinal degeneration (HP:0001146)6.48902482
11Abolished electroretinogram (ERG) (HP:0000550)5.90912335
12Increased corneal curvature (HP:0100692)5.86128258
13Keratoconus (HP:0000563)5.86128258
14* Scotoma (HP:0000575)5.75320820
15Dyschromatopsia (HP:0007641)5.34612108
16Type II diabetes mellitus (HP:0005978)4.68031183
17* Photophobia (HP:0000613)4.62791836
18Cone-rod dystrophy (HP:0000548)4.50683189
19Abnormality of the renal cortex (HP:0011035)4.14258768
20Posterior subcapsular cataract (HP:0007787)4.13571110
21Macular degeneration (HP:0000608)4.07627635
22* Severe visual impairment (HP:0001141)4.02835851
23Renal cortical cysts (HP:0000803)3.95265246
24Retinitis pigmentosa (HP:0000510)3.87522902
25Nephronophthisis (HP:0000090)3.62137051
26Constricted visual fields (HP:0001133)3.53996753
27Choroideremia (HP:0001139)3.43111866
28Epileptic encephalopathy (HP:0200134)3.41750153
29Type II lissencephaly (HP:0007260)3.41538495
30Septo-optic dysplasia (HP:0100842)3.30593591
31Vitreoretinal degeneration (HP:0000655)3.28599409
32Abnormality of the renal medulla (HP:0100957)3.15748181
33Febrile seizures (HP:0002373)3.12753345
34Tubular atrophy (HP:0000092)3.00278344
35Congenital sensorineural hearing impairment (HP:0008527)2.97181712
36Abnormal drinking behavior (HP:0030082)2.89075498
37Polydipsia (HP:0001959)2.89075498
38Gait imbalance (HP:0002141)2.82627782
39Congenital primary aphakia (HP:0007707)2.78551163
40Progressive visual loss (HP:0000529)2.74812893
41Intestinal atresia (HP:0011100)2.72781045
42Rib fusion (HP:0000902)2.67134167
43Abnormal gallbladder physiology (HP:0012438)2.59992342
44Cholecystitis (HP:0001082)2.59992342
45Decreased electroretinogram (ERG) amplitude (HP:0000654)2.58516592
46Medial flaring of the eyebrow (HP:0010747)2.56523063
47Stomatitis (HP:0010280)2.54371630
48Subcapsular cataract (HP:0000523)2.54191879
49Cerebellar dysplasia (HP:0007033)2.54126475
50Nephrogenic diabetes insipidus (HP:0009806)2.53499849
51Polyuria (HP:0000103)2.48091827
52Generalized aminoaciduria (HP:0002909)2.47235591
53Acute lymphatic leukemia (HP:0006721)2.44816907
54Severe Myopia (HP:0011003)2.44321369
55Hypoplasia of the pons (HP:0012110)2.38792223
56Gaze-evoked nystagmus (HP:0000640)2.36373716
57Hepatic necrosis (HP:0002605)2.36266356
58Ketosis (HP:0001946)2.35361228
59Oligodactyly (hands) (HP:0001180)2.31933839
60Lissencephaly (HP:0001339)2.29943080
61Abnormality of the pons (HP:0007361)2.29244749
62Proximal tubulopathy (HP:0000114)2.27588110
63Optic disc pallor (HP:0000543)2.25434150
64Chronic hepatic failure (HP:0100626)2.23158909
65Polyphagia (HP:0002591)2.18768429
66Poor coordination (HP:0002370)2.18198390
67Abnormal biliary tract physiology (HP:0012439)2.18178818
68Bile duct proliferation (HP:0001408)2.18178818
69Aplasia/Hypoplasia of the spleen (HP:0010451)2.17638092
70Hyperventilation (HP:0002883)2.17314840
71Inability to walk (HP:0002540)2.17024160
72Severe muscular hypotonia (HP:0006829)2.13879064
73Genetic anticipation (HP:0003743)2.13766688
74Broad-based gait (HP:0002136)2.11717441
75Visual hallucinations (HP:0002367)2.11688145
76Absence seizures (HP:0002121)2.11148227
77Congenital hepatic fibrosis (HP:0002612)2.07829183
78Absent speech (HP:0001344)2.07242602
79Sclerocornea (HP:0000647)2.04981176
80Wide nasal bridge (HP:0000431)2.04939320
81Hypoglycemic coma (HP:0001325)2.04129260
82Tubulointerstitial nephritis (HP:0001970)2.03490051
83Progressive inability to walk (HP:0002505)2.01317562
84Abnormal urine output (HP:0012590)2.00793316
85* Congenital stationary night blindness (HP:0007642)16.5662077
86IgG deficiency (HP:0004315)1.99037545
87Hypomagnesemia (HP:0002917)1.98973445
88Decreased circulating renin level (HP:0003351)1.96746293
89Prolonged QT interval (HP:0001657)1.95059769
90Pachygyria (HP:0001302)1.94169588
91* Aplasia/Hypoplasia of the fovea (HP:0008060)1.92757389
92* Hypoplasia of the fovea (HP:0007750)1.92757389
93Glycosuria (HP:0003076)1.91210038
94Abnormality of urine glucose concentration (HP:0011016)1.91210038
95Abnormality of the labia minora (HP:0012880)1.90732320
96Retinal dysplasia (HP:0007973)1.88711677
97Hyperglycinuria (HP:0003108)1.88214620
98Aplasia/Hypoplasia of the tibia (HP:0005772)1.86803046
99Vaginal atresia (HP:0000148)1.86096924
100Progressive cerebellar ataxia (HP:0002073)1.84765579
101Genital tract atresia (HP:0001827)1.83382358
102Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.83126460
103Stomach cancer (HP:0012126)1.80543131
104Postaxial foot polydactyly (HP:0001830)1.79099457
105Retinal atrophy (HP:0001105)1.78471727
106Asplenia (HP:0001746)1.78286672
107Patellar aplasia (HP:0006443)1.77479141
108Progressive microcephaly (HP:0000253)1.76693681
109Dialeptic seizures (HP:0011146)1.76436556
110Hemiparesis (HP:0001269)1.75326150
111Aplasia/Hypoplasia of the lens (HP:0008063)1.73893803
112Abnormality of renal excretion (HP:0011036)1.73795901
113Neoplasm of the heart (HP:0100544)1.73177412
114True hermaphroditism (HP:0010459)1.71608071
115Furrowed tongue (HP:0000221)1.71276352
116Hepatocellular necrosis (HP:0001404)1.68894097
117Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.68804444
118Anencephaly (HP:0002323)1.68375132
119Dysdiadochokinesis (HP:0002075)1.66209881
120Optic nerve hypoplasia (HP:0000609)1.65959958
121Anomalous pulmonary venous return (HP:0010772)1.65672479
122Mutism (HP:0002300)1.65496972
123Dynein arm defect of respiratory motile cilia (HP:0012255)1.65468152
124Absent/shortened dynein arms (HP:0200106)1.65468152
125Highly arched eyebrow (HP:0002553)1.65373826
126Aplasia/Hypoplasia of the patella (HP:0006498)1.65355560
127Widely spaced teeth (HP:0000687)1.65169039
128Increased CSF lactate (HP:0002490)1.64687246
129Stage 5 chronic kidney disease (HP:0003774)1.63268807
130Chorioretinal coloboma (HP:0000567)1.59854503
131Absent septum pellucidum (HP:0001331)1.59290647
132Ependymoma (HP:0002888)1.58672361
133Pancreatic fibrosis (HP:0100732)1.57953336
134Optic atrophy (HP:0000648)1.55611796
135Left ventricular hypertrophy (HP:0001712)1.50162108
136Increased neuronal autofluorescent lipopigment (HP:0002074)1.47924244
137Pancreatic cysts (HP:0001737)1.41578788
138Abnormality of the astrocytes (HP:0100707)1.41462312
139Astrocytoma (HP:0009592)1.41462312
140Aplasia/Hypoplasia of the tongue (HP:0010295)1.41408894
141Cystic liver disease (HP:0006706)1.34432497
142Abnormality of the septum pellucidum (HP:0007375)1.34107369
143Abnormality of abdominal situs (HP:0011620)1.32093326
144Abdominal situs inversus (HP:0003363)1.32093326
145* Astigmatism (HP:0000483)1.31402998
146Increased cerebral lipofuscin (HP:0011813)1.30548114
147Partial agenesis of the corpus callosum (HP:0001338)1.29016349
148Generalized tonic-clonic seizures (HP:0002069)1.28840600
149Specific learning disability (HP:0001328)1.28248898
150Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.25907070
151Polar cataract (HP:0010696)1.25819862
152Truncal ataxia (HP:0002078)1.25449908
153Decreased testicular size (HP:0008734)1.22391486
154Horizontal nystagmus (HP:0000666)1.22183280
155Abnormal pupillary function (HP:0007686)1.21830004
156EEG with generalized epileptiform discharges (HP:0011198)1.19837415
157Abnormal EKG (HP:0003115)1.19193813
158Ventricular fibrillation (HP:0001663)1.19092273
159Growth hormone deficiency (HP:0000824)1.18582397
160Unsteady gait (HP:0002317)1.16953229
161Abnormality of the lower motor neuron (HP:0002366)1.16086677
162Epileptiform EEG discharges (HP:0011182)1.14590624
163Depression (HP:0000716)1.14221689
164Supranuclear gaze palsy (HP:0000605)1.12493924
165Hypoventilation (HP:0002791)1.12014314
166Focal motor seizures (HP:0011153)1.11661673
167Molar tooth sign on MRI (HP:0002419)1.11321675
168Abnormality of midbrain morphology (HP:0002418)1.11321675
169Volvulus (HP:0002580)1.10861416
170Broad foot (HP:0001769)1.09715053

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.04413829
2GRK15.90999706
3PBK4.77311855
4PAK64.17046136
5ADRBK23.13725835
6WNK43.01306937
7NEK12.94655407
8MAP3K42.91780015
9MAP4K22.69802546
10PRPF4B2.56896791
11TXK2.43774075
12NUAK12.36472322
13WNK32.19418878
14STK382.16135248
15DYRK1A2.12604970
16PINK12.05528603
17TAOK22.04518336
18EPHA31.94382706
19MAP3K71.92784397
20NME11.87231539
21DAPK21.83641626
22MARK11.79816320
23INSRR1.76184026
24ACVR1B1.74953869
25RIPK11.73138677
26MAP3K91.70675808
27CAMK1D1.68273513
28MAP2K61.66143128
29CDK31.63986571
30BLK1.61479504
31PHKG21.61385010
32PHKG11.61385010
33IRAK21.59882854
34FES1.57237558
35MAP3K131.52075945
36AKT31.51532184
37PTK2B1.51255314
38TNK21.46753387
39CDK81.45008237
40CAMK1G1.40504875
41MINK11.34677892
42CSNK1G31.32595478
43ZAK1.31123157
44MAPK151.27070985
45CSNK1G21.22879143
46CSNK1A1L1.21096805
47CSNK1G11.18161245
48MAPK131.17686255
49PRKAA11.12873929
50SIK21.11028751
51MAP4K11.10018461
52OXSR11.09981730
53CAMK11.08947070
54MAPKAPK31.04909904
55BMPR1B1.03343490
56CAMK2D1.02247402
57SGK2231.02184462
58SGK4941.02184462
59CAMKK11.01792976
60ERBB21.00184410
61STK390.98749351
62TLK10.97878898
63IRAK10.92479896
64PLK20.91885575
65PRKD20.90937124
66PKN10.90409244
67CDK90.90322700
68LATS10.89603808
69BRD40.88201455
70STK38L0.87294777
71SYK0.87053030
72FER0.86485232
73TAOK30.81016210
74PRKCI0.79980378
75KIT0.75389620
76PRKCZ0.75094761
77ITK0.74331512
78HIPK20.73163756
79IKBKB0.72851398
80CLK10.72120552
81PRKCB0.71669355
82DYRK1B0.71213946
83CDK50.70710475
84MAPK100.70398049
85TEC0.70315794
86STK30.67232381
87MAPK120.66134740
88TNIK0.65807025
89ADRBK10.65619230
90MST40.65082668
91MAP2K70.64830694
92RPS6KA30.64796116
93BRSK20.64573073
94GRK50.63912064
95CDK140.62760592
96CAMK40.62496419
97NEK20.61493207
98IRAK40.61489527
99ROCK20.59176827
100PRKCG0.58436250
101CCNB10.58143437
102CAMKK20.57976319
103CSF1R0.57788797
104CSNK1D0.57689327
105SGK20.57647100
106PRKG10.57194812
107GSK3B0.57076830
108KSR20.56917091
109CDK150.56863023
110PRKCQ0.56125597
111MAPK70.55892795
112PLK30.55888317
113CAMK2A0.55732705
114EPHA40.55637704
115MARK20.54743865
116PRKAA20.54288425
117PRKCA0.54071630
118CDC42BPA0.53160513
119CSNK1A10.52260672
120NTRK30.51678967
121CDK180.51599367
122ATR0.50663153
123DYRK20.49936073
124PRKACG0.49293175
125MAPK90.49230425
126CDK11A0.48951948
127MAPK140.48879613
128VRK10.48816573
129LYN0.47345496
130BMX0.47237720
131PRKG20.47236849
132SGK30.47051530
133PRKACA0.46620251
134ZAP700.46344124
135RPS6KB10.46243511
136ICK0.46179844
137CASK0.45755841
138CHUK0.45214173
139TRPM70.45039934
140GRK60.44524733
141IKBKE0.44009602
142PRKACB0.43807401
143NLK0.43333488
144MUSK0.42908320
145SGK10.41284519
146CDK10.41070459
147YES10.40263068
148MAPK80.40022784
149PAK30.39588504
150MARK30.39439897
151NTRK20.39173267
152NEK60.37133464
153PRKCE0.36467400
154RPS6KA50.36183212
155PRKDC0.36015845
156MAP3K50.33685693
157PLK40.33071451
158TRIM280.33062777
159DAPK10.30082913
160GRK70.29988941
161BCKDK0.28093087

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.45528398
2Nicotine addiction_Homo sapiens_hsa050333.09977618
3* GABAergic synapse_Homo sapiens_hsa047272.71361664
4Morphine addiction_Homo sapiens_hsa050322.61688942
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.56886915
6Linoleic acid metabolism_Homo sapiens_hsa005912.50431629
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.39354681
8Primary immunodeficiency_Homo sapiens_hsa053402.19966454
9* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.16898652
10Circadian rhythm_Homo sapiens_hsa047102.15012874
11Butanoate metabolism_Homo sapiens_hsa006502.08055477
12Olfactory transduction_Homo sapiens_hsa047402.03174819
13Phototransduction_Homo sapiens_hsa0474411.8427529
14Circadian entrainment_Homo sapiens_hsa047131.96426952
15Ether lipid metabolism_Homo sapiens_hsa005651.94771231
16Fructose and mannose metabolism_Homo sapiens_hsa000511.86485299
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.69205611
18Selenocompound metabolism_Homo sapiens_hsa004501.65533818
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.63825148
20Nitrogen metabolism_Homo sapiens_hsa009101.61393048
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60007036
22Caffeine metabolism_Homo sapiens_hsa002321.54593321
23Tryptophan metabolism_Homo sapiens_hsa003801.49829579
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47577748
25Basal transcription factors_Homo sapiens_hsa030221.47070447
26Fanconi anemia pathway_Homo sapiens_hsa034601.45867269
27Homologous recombination_Homo sapiens_hsa034401.44455438
28Protein export_Homo sapiens_hsa030601.44236928
29Glutamatergic synapse_Homo sapiens_hsa047241.44103856
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.39267938
31Type I diabetes mellitus_Homo sapiens_hsa049401.37114202
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32433706
33Salivary secretion_Homo sapiens_hsa049701.28800056
34beta-Alanine metabolism_Homo sapiens_hsa004101.21445986
35* Insulin secretion_Homo sapiens_hsa049111.18237189
36Dopaminergic synapse_Homo sapiens_hsa047281.16867498
37* Cholinergic synapse_Homo sapiens_hsa047251.15044421
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13682039
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10738219
40Peroxisome_Homo sapiens_hsa041461.09789837
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06375305
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03181308
43Asthma_Homo sapiens_hsa053101.02970575
44* Oxytocin signaling pathway_Homo sapiens_hsa049211.00802285
45Pentose phosphate pathway_Homo sapiens_hsa000301.00365722
46Biosynthesis of amino acids_Homo sapiens_hsa012301.00324916
47Galactose metabolism_Homo sapiens_hsa000520.98790190
48* Serotonergic synapse_Homo sapiens_hsa047260.98556642
49Central carbon metabolism in cancer_Homo sapiens_hsa052300.98088017
50Graft-versus-host disease_Homo sapiens_hsa053320.97834864
51Arachidonic acid metabolism_Homo sapiens_hsa005900.96219577
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.95104657
53Oxidative phosphorylation_Homo sapiens_hsa001900.94152120
54Collecting duct acid secretion_Homo sapiens_hsa049660.93775789
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92640739
56* Renin secretion_Homo sapiens_hsa049240.89182766
57Autoimmune thyroid disease_Homo sapiens_hsa053200.89042977
58Allograft rejection_Homo sapiens_hsa053300.88676249
59Propanoate metabolism_Homo sapiens_hsa006400.88538203
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88367748
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87764976
62Chemical carcinogenesis_Homo sapiens_hsa052040.87034177
63ABC transporters_Homo sapiens_hsa020100.86597145
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85319472
65* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80408848
66Fatty acid biosynthesis_Homo sapiens_hsa000610.80392792
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78839740
68Ovarian steroidogenesis_Homo sapiens_hsa049130.76394671
69Taste transduction_Homo sapiens_hsa047420.75841596
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75742505
71* Cardiac muscle contraction_Homo sapiens_hsa042600.74983676
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74003690
73Mineral absorption_Homo sapiens_hsa049780.70382761
74* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69781459
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69105910
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68597994
77One carbon pool by folate_Homo sapiens_hsa006700.67592348
78Type II diabetes mellitus_Homo sapiens_hsa049300.65707992
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65386942
80* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63774876
81* Dilated cardiomyopathy_Homo sapiens_hsa054140.63547848
82* cAMP signaling pathway_Homo sapiens_hsa040240.63317020
83mTOR signaling pathway_Homo sapiens_hsa041500.61893931
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59903306
85Fat digestion and absorption_Homo sapiens_hsa049750.59627669
86T cell receptor signaling pathway_Homo sapiens_hsa046600.59330688
87Inositol phosphate metabolism_Homo sapiens_hsa005620.58676859
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58511549
89* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56974347
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.56747136
91Gap junction_Homo sapiens_hsa045400.56412867
92Dorso-ventral axis formation_Homo sapiens_hsa043200.54762706
93Cocaine addiction_Homo sapiens_hsa050300.53622737
94* Calcium signaling pathway_Homo sapiens_hsa040200.53559825
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52329517
96Parkinsons disease_Homo sapiens_hsa050120.52218930
97Metabolic pathways_Homo sapiens_hsa011000.51689852
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51445640
99* Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50782794
100Alcoholism_Homo sapiens_hsa050340.50201397
101HIF-1 signaling pathway_Homo sapiens_hsa040660.48045607
102Antigen processing and presentation_Homo sapiens_hsa046120.46047652
103Retinol metabolism_Homo sapiens_hsa008300.45719598
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45051477
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.44301918
106Fatty acid metabolism_Homo sapiens_hsa012120.44292745
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43560555
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41775334
109Carbon metabolism_Homo sapiens_hsa012000.41760941
110Purine metabolism_Homo sapiens_hsa002300.41222382
111Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39977317
112Long-term depression_Homo sapiens_hsa047300.39847892
113AMPK signaling pathway_Homo sapiens_hsa041520.39482430
114Gastric acid secretion_Homo sapiens_hsa049710.38761799
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37334269
116Bile secretion_Homo sapiens_hsa049760.36623073
117Amphetamine addiction_Homo sapiens_hsa050310.35292106
118Pancreatic secretion_Homo sapiens_hsa049720.35225072
119Lysine degradation_Homo sapiens_hsa003100.34095839
120Fatty acid elongation_Homo sapiens_hsa000620.32541141
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32286833
122Hematopoietic cell lineage_Homo sapiens_hsa046400.32204834
123* Vascular smooth muscle contraction_Homo sapiens_hsa042700.32154588
124Vibrio cholerae infection_Homo sapiens_hsa051100.31352616
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29833472
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28835787
127Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28092383
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.27369245
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.25889169
130Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24896224
131Glucagon signaling pathway_Homo sapiens_hsa049220.23811770
132Choline metabolism in cancer_Homo sapiens_hsa052310.23455923
133Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20205194
134Rheumatoid arthritis_Homo sapiens_hsa053230.19936712
135* MAPK signaling pathway_Homo sapiens_hsa040100.19660285
136Long-term potentiation_Homo sapiens_hsa047200.19150298
137Renal cell carcinoma_Homo sapiens_hsa052110.17579170
138Ras signaling pathway_Homo sapiens_hsa040140.17270699
139Lysosome_Homo sapiens_hsa041420.16565020
140Chemokine signaling pathway_Homo sapiens_hsa040620.15781529
141Thyroid hormone synthesis_Homo sapiens_hsa049180.15148588
142Endocytosis_Homo sapiens_hsa041440.12766335
143Regulation of autophagy_Homo sapiens_hsa041400.12575602
144Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.12515949
145Sphingolipid metabolism_Homo sapiens_hsa006000.11652182
146Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.11050413
147Cyanoamino acid metabolism_Homo sapiens_hsa004600.10240388
148Axon guidance_Homo sapiens_hsa043600.10005582
149Glycerolipid metabolism_Homo sapiens_hsa005610.09761630
150Colorectal cancer_Homo sapiens_hsa052100.08405386
151Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.07889667
152alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.07684385
153RNA degradation_Homo sapiens_hsa030180.07303827
154Melanoma_Homo sapiens_hsa052180.06770616
155Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.06086669
156Arginine biosynthesis_Homo sapiens_hsa002200.06031525
157Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.05887694

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