CACNA1I

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the pore-forming alpha subunit of a voltage gated calcium channel. The encoded protein is a member of a subfamily of calcium channels referred to as is a low voltage-activated, T-type, calcium channel. The channel encoded by this protein is characterized by a slower activation and inactivation compared to other T-type calcium channels. This protein may be involved in calcium signaling in neurons. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)6.60667884
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.38066342
3synaptic vesicle maturation (GO:0016188)6.28636799
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.27173375
5vocalization behavior (GO:0071625)5.71686503
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.67467427
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.51003044
8synaptic vesicle exocytosis (GO:0016079)5.32825054
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.26281836
10regulation of synaptic vesicle exocytosis (GO:2000300)5.21215560
11glutamate secretion (GO:0014047)5.13713059
12regulation of glutamate receptor signaling pathway (GO:1900449)5.13475197
13exploration behavior (GO:0035640)4.83189700
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.82408443
15regulation of synapse structural plasticity (GO:0051823)4.80878768
16protein localization to synapse (GO:0035418)4.80527264
17regulation of long-term neuronal synaptic plasticity (GO:0048169)4.79208254
18neuronal action potential propagation (GO:0019227)4.74186450
19regulation of neuronal synaptic plasticity (GO:0048168)4.66151967
20regulation of synaptic vesicle transport (GO:1902803)4.59458907
21neurotransmitter secretion (GO:0007269)4.56845561
22cerebellar granule cell differentiation (GO:0021707)4.44646852
23layer formation in cerebral cortex (GO:0021819)4.43618535
24neurotransmitter-gated ion channel clustering (GO:0072578)4.40153101
25dendritic spine morphogenesis (GO:0060997)4.38627706
26L-amino acid import (GO:0043092)4.33506175
27synaptic transmission, glutamatergic (GO:0035249)4.32820320
28gamma-aminobutyric acid transport (GO:0015812)4.30832250
29glutamate receptor signaling pathway (GO:0007215)4.24581929
30long-term memory (GO:0007616)4.22507266
31negative regulation of cell killing (GO:0031342)4.18028687
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.18028687
33positive regulation of membrane potential (GO:0045838)4.17376465
34regulation of excitatory postsynaptic membrane potential (GO:0060079)4.13779203
35neuron-neuron synaptic transmission (GO:0007270)4.12389557
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.11239801
37regulation of dendritic spine morphogenesis (GO:0061001)4.11049112
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.08758142
39neuron cell-cell adhesion (GO:0007158)4.08488936
40cellular potassium ion homeostasis (GO:0030007)4.01854999
41prepulse inhibition (GO:0060134)3.91760636
42regulation of postsynaptic membrane potential (GO:0060078)3.91018150
43negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.87930761
44neuromuscular process controlling balance (GO:0050885)3.85373056
45sodium ion export (GO:0071436)3.83431117
46signal complex assembly (GO:0007172)3.81700614
47auditory behavior (GO:0031223)3.80254705
48regulation of synaptic plasticity (GO:0048167)3.76303778
49positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.74391912
50positive regulation of synapse maturation (GO:0090129)3.72222077
51regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.70196876
52activation of protein kinase A activity (GO:0034199)3.69766623
53G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.61717569
54negative T cell selection (GO:0043383)3.61385409
55regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.60319342
56regulation of synaptic transmission, glutamatergic (GO:0051966)3.60246110
57amino acid import (GO:0043090)3.59798381
58proline transport (GO:0015824)3.58769704
59neurotransmitter transport (GO:0006836)3.58298460
60negative thymic T cell selection (GO:0045060)3.58049041
61long-term synaptic potentiation (GO:0060291)3.56486601
62positive regulation of neurotransmitter transport (GO:0051590)3.55787993
63transmission of nerve impulse (GO:0019226)3.55331704
64positive regulation of synaptic transmission, GABAergic (GO:0032230)3.54638722
65positive regulation of neurotransmitter secretion (GO:0001956)3.53514311
66regulation of ARF protein signal transduction (GO:0032012)3.52773240
67positive regulation of Rap GTPase activity (GO:0032854)3.52279239
68regulation of neurotransmitter secretion (GO:0046928)3.52172799
69response to auditory stimulus (GO:0010996)3.48489170
70cerebellar Purkinje cell differentiation (GO:0021702)3.47902477
71positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.47462234
72negative regulation of synaptic transmission, GABAergic (GO:0032229)3.45255088
73glycine transport (GO:0015816)3.42875385
74positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.42415861
75regulation of dendritic spine development (GO:0060998)3.40883522
76regulation of neurotransmitter levels (GO:0001505)3.37446334
77regulation of synapse maturation (GO:0090128)3.33855671
78positive T cell selection (GO:0043368)3.33712362
79gamma-aminobutyric acid signaling pathway (GO:0007214)3.31862115
80neuromuscular process controlling posture (GO:0050884)3.31035489
81regulation of neurotransmitter transport (GO:0051588)3.30123533
82membrane hyperpolarization (GO:0060081)3.29430244
83regulation of Rap GTPase activity (GO:0032317)3.25933842
84* membrane depolarization (GO:0051899)3.25214788
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.24866181
86positive regulation of gamma-delta T cell activation (GO:0046645)3.24608840
87G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.23926636
88synaptic vesicle endocytosis (GO:0048488)3.22432403
89regulation of vesicle fusion (GO:0031338)3.21933622
90neuronal ion channel clustering (GO:0045161)3.21875110
91thymic T cell selection (GO:0045061)3.20210505
92response to histamine (GO:0034776)3.17751937
93negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.16943511
94cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.15684254
95regulation of voltage-gated calcium channel activity (GO:1901385)3.14903989
96neuron recognition (GO:0008038)3.13918336
97positive regulation of synaptic transmission (GO:0050806)3.11657201
98positive regulation of dendritic spine development (GO:0060999)3.11639461
99learning (GO:0007612)3.10875037
100behavioral response to cocaine (GO:0048148)3.10799554
101dendritic spine organization (GO:0097061)3.10308163
102cell differentiation in hindbrain (GO:0021533)3.09213825
103neuromuscular process (GO:0050905)3.09019510
104T cell selection (GO:0045058)3.07793180
105positive thymic T cell selection (GO:0045059)3.07552694
106potassium ion import (GO:0010107)3.07427827
107postsynaptic membrane organization (GO:0001941)3.07241116
108dendrite morphogenesis (GO:0048813)3.06834196
109* membrane depolarization during action potential (GO:0086010)3.05469297
110vesicle transport along microtubule (GO:0047496)3.04546823
111regulation of synaptic transmission (GO:0050804)3.03709686
112behavioral defense response (GO:0002209)3.03179566
113behavioral fear response (GO:0001662)3.03179566
114mechanosensory behavior (GO:0007638)3.02535911
115intraspecies interaction between organisms (GO:0051703)3.02276355
116social behavior (GO:0035176)3.02276355
117striatum development (GO:0021756)3.01557433
118long term synaptic depression (GO:0060292)3.00205114
119cell communication by electrical coupling (GO:0010644)2.98370833
120visual learning (GO:0008542)2.95545753
121positive regulation of dendritic spine morphogenesis (GO:0061003)2.94871651
122regulation of female receptivity (GO:0045924)2.94695726
123regulation of gamma-delta T cell differentiation (GO:0045586)2.93136667
124potassium ion homeostasis (GO:0055075)2.91864112
125response to interleukin-15 (GO:0070672)2.89559676
126regulation of ARF GTPase activity (GO:0032312)2.88854594
127negative regulation of inclusion body assembly (GO:0090084)2.84770167
128activated T cell proliferation (GO:0050798)2.84733491
129tolerance induction (GO:0002507)2.81954188
130negative regulation of dendrite morphogenesis (GO:0050774)2.80555566
131cytoskeletal anchoring at plasma membrane (GO:0007016)2.78641278
132leukocyte aggregation (GO:0070486)2.74203487
133regulation of exocytosis (GO:0017157)2.71198995
134central nervous system myelination (GO:0022010)2.69785442
135axon ensheathment in central nervous system (GO:0032291)2.69785442
136regulation of gamma-delta T cell activation (GO:0046643)2.65834419

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.14323914
2* RARB_27405468_Chip-Seq_BRAIN_Mouse3.15534107
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.08152886
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.05889531
5GBX2_23144817_ChIP-Seq_PC3_Human3.05777254
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05444112
7* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03338124
8* DROSHA_22980978_ChIP-Seq_HELA_Human2.83771557
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.81649510
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72733761
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72733761
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59076607
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56951282
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.56503805
15IKZF1_21737484_ChIP-ChIP_HCT116_Human2.54933709
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52709107
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.41059318
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40110167
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36918201
20* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.34625933
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.33354294
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.31962303
23* EZH2_27304074_Chip-Seq_ESCs_Mouse2.29489440
24* EZH2_27294783_Chip-Seq_ESCs_Mouse2.26169251
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.21280593
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09369907
27RUNX_20019798_ChIP-Seq_JUKART_Human2.04550654
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.02793560
29* KDM2B_26808549_Chip-Seq_DND41_Human1.97155985
30AR_21572438_ChIP-Seq_LNCaP_Human1.95146750
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85352390
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81456797
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.80811435
34TCF7_22412390_ChIP-Seq_EML_Mouse1.78013697
35LXR_22292898_ChIP-Seq_THP-1_Human1.73094904
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63242808
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.61913652
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58010624
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.56968317
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56459674
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.55548218
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.54763731
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.50937381
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46194409
45SMAD4_21799915_ChIP-Seq_A2780_Human1.45198859
46KDM2B_26808549_Chip-Seq_K562_Human1.40666568
47* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38805805
48SMC4_20622854_ChIP-Seq_HELA_Human1.38362957
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.36288832
50TAF15_26573619_Chip-Seq_HEK293_Human1.34052348
51RING1B_27294783_Chip-Seq_ESCs_Mouse1.32502184
52* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31042014
53GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29428122
54MAF_26560356_Chip-Seq_TH1_Human1.29330539
55* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27969082
56* SOX2_21211035_ChIP-Seq_LN229_Gbm1.26706709
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26039119
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25975633
59AR_19668381_ChIP-Seq_PC3_Human1.25918174
60P68_20966046_ChIP-Seq_HELA_Human1.25507958
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24363437
62* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24067935
63MAF_26560356_Chip-Seq_TH2_Human1.23706609
64* OCT4_19829295_ChIP-Seq_ESCs_Human1.23620897
65ZNF274_21170338_ChIP-Seq_K562_Hela1.23159110
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22665239
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19060026
68GATA1_19941827_ChIP-Seq_MEL_Mouse1.18668261
69UTX_26944678_Chip-Seq_JUKART_Human1.18666983
70ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17981687
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17561788
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16503417
73STAT3_23295773_ChIP-Seq_U87_Human1.14136226
74SCL_19346495_ChIP-Seq_HPC-7_Human1.13591332
75RING1B_27294783_Chip-Seq_NPCs_Mouse1.11391630
76SA1_27219007_Chip-Seq_ERYTHROID_Human1.10993223
77* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10672955
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.09836760
79* GATA1_19941826_ChIP-Seq_K562_Human1.09627524
80KLF4_19829295_ChIP-Seq_ESCs_Human1.09611147
81AR_25329375_ChIP-Seq_VCAP_Human1.07983642
82RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07300285
83SPI1_23127762_ChIP-Seq_K562_Human1.06925331
84KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06436758
85TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05606401
86MYC_22102868_ChIP-Seq_BL_Human1.05263540
87P300_19829295_ChIP-Seq_ESCs_Human1.03783108
88MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03643919
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03624504
90* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03262279
91CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03245893
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03240708
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02867341
94CREB1_26743006_Chip-Seq_LNCaP_Human1.02487281
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00883935
96* TCF4_23295773_ChIP-Seq_U87_Human1.00591281
97RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00083858
98ARNT_22903824_ChIP-Seq_MCF-7_Human0.99942402
99DPY_21335234_ChIP-Seq_ESCs_Mouse0.99907003
100AHR_22903824_ChIP-Seq_MCF-7_Human0.99322247
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99281114
102RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98728455
103MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98650122
104TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97745376
105* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97173069
106GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95823547
107TP53_16413492_ChIP-PET_HCT116_Human0.95373566
108YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95317975
109SMAD3_21741376_ChIP-Seq_HESCs_Human0.94941780
110STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.94689139
111SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94408230
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94349964
113SMAD3_21741376_ChIP-Seq_ESCs_Human0.92051473
114TET1_21490601_ChIP-Seq_MESCs_Mouse0.91980313
115ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90900214
116CTCF_27219007_Chip-Seq_Bcells_Human0.90777865
117MYB_26560356_Chip-Seq_TH2_Human0.90187558
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89971696
119FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89636364
120OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89632669
121SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89313083
122PRDM14_20953172_ChIP-Seq_ESCs_Human0.89029777
123RXR_22108803_ChIP-Seq_LS180_Human0.88855176
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88749792
125VDR_21846776_ChIP-Seq_THP-1_Human0.88747972
126SMAD4_21741376_ChIP-Seq_HESCs_Human0.88302658
127SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87736664
128KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.87375693
129TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87269631
130RUNX1_22412390_ChIP-Seq_EML_Mouse0.87136862
131SA1_27219007_Chip-Seq_Bcells_Human0.86633397
132GATA3_27048872_Chip-Seq_THYMUS_Human0.86461768
133ELF1_20517297_ChIP-Seq_JURKAT_Human0.86215681
134DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86211088
135* SMAD4_21741376_ChIP-Seq_ESCs_Human0.85865780
136BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85214095
137PIAS1_25552417_ChIP-Seq_VCAP_Human0.83987158
138TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.83712241
139NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83250160
140CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83139869
141RUNX2_22187159_ChIP-Seq_PCA_Human0.83053369
142* BCOR_27268052_Chip-Seq_Bcells_Human0.82436932
143CDX2_19796622_ChIP-Seq_MESCs_Mouse0.81960018
144SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81922824
145VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81856013
146* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.81851824
147AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81170576
148CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80953390
149CBX2_27304074_Chip-Seq_ESCs_Mouse0.80770938
150TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.79540010
151* KDM2B_26808549_Chip-Seq_JURKAT_Human0.79041225

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.24906769
2MP0003880_abnormal_central_pattern4.70538168
3MP0003635_abnormal_synaptic_transmissio4.44651625
4MP0002822_catalepsy4.12468502
5MP0004270_analgesia3.78325351
6MP0009745_abnormal_behavioral_response3.70543795
7MP0002063_abnormal_learning/memory/cond3.52016999
8MP0009046_muscle_twitch3.35578892
9MP0002064_seizures3.32334248
10MP0005423_abnormal_somatic_nervous3.04562639
11MP0001968_abnormal_touch/_nociception3.00174670
12MP0002572_abnormal_emotion/affect_behav2.92232579
13MP0001486_abnormal_startle_reflex2.76527651
14MP0002272_abnormal_nervous_system2.69064769
15MP0002734_abnormal_mechanical_nocicepti2.57540461
16MP0001501_abnormal_sleep_pattern2.31279379
17MP0008569_lethality_at_weaning2.24041266
18MP0003763_abnormal_thymus_physiology2.18816459
19MP0002909_abnormal_adrenal_gland2.11969313
20MP0002736_abnormal_nociception_after2.11734986
21MP0001440_abnormal_grooming_behavior2.06080089
22MP0009780_abnormal_chondrocyte_physiolo1.99651776
23MP0002735_abnormal_chemical_nociception1.94473017
24MP0002067_abnormal_sensory_capabilities1.92350001
25MP0002733_abnormal_thermal_nociception1.91699588
26MP0001970_abnormal_pain_threshold1.90649899
27MP0003329_amyloid_beta_deposits1.88352990
28MP0004811_abnormal_neuron_physiology1.81032030
29MP0004924_abnormal_behavior1.80998140
30MP0005386_behavior/neurological_phenoty1.80998140
31MP0003879_abnormal_hair_cell1.79142035
32MP0002557_abnormal_social/conspecific_i1.75563530
33MP0002184_abnormal_innervation1.66244593
34MP0001348_abnormal_lacrimal_gland1.57614440
35MP0005646_abnormal_pituitary_gland1.54894875
36MP0004858_abnormal_nervous_system1.54342774
37MP0004885_abnormal_endolymph1.52990795
38MP0003436_decreased_susceptibility_to1.52250764
39MP0000778_abnormal_nervous_system1.50316175
40MP0000955_abnormal_spinal_cord1.48592705
41MP0003633_abnormal_nervous_system1.47308248
42MP0001984_abnormal_olfaction1.45393481
43MP0003787_abnormal_imprinting1.44010192
44MP0002066_abnormal_motor_capabilities/c1.43359894
45MP0002882_abnormal_neuron_morphology1.33807246
46MP0004130_abnormal_muscle_cell1.33214344
47MP0001986_abnormal_taste_sensitivity1.30862631
48MP0008961_abnormal_basal_metabolism1.27903606
49MP0001529_abnormal_vocalization1.26593087
50MP0000569_abnormal_digit_pigmentation1.25101670
51MP0008874_decreased_physiological_sensi1.22105739
52MP0003631_nervous_system_phenotype1.21095193
53MP0008872_abnormal_physiological_respon1.20088501
54MP0001502_abnormal_circadian_rhythm1.17494418
55MP0005671_abnormal_response_to1.13896398
56MP0003724_increased_susceptibility_to1.13442614
57MP0004142_abnormal_muscle_tone1.12983881
58MP0005645_abnormal_hypothalamus_physiol1.11874015
59MP0003075_altered_response_to1.10679523
60MP0002152_abnormal_brain_morphology1.06627682
61MP0001177_atelectasis1.03258600
62MP0005310_abnormal_salivary_gland1.02022198
63MP0001905_abnormal_dopamine_level1.01751495
64MP0005000_abnormal_immune_tolerance1.01299057
65MP0000703_abnormal_thymus_morphology0.99884268
66MP0003690_abnormal_glial_cell0.99085669
67MP0003866_abnormal_defecation0.98379100
68MP0001800_abnormal_humoral_immune0.97259111
69MP0004510_myositis0.96201017
70MP0002229_neurodegeneration0.94745358
71MP0002069_abnormal_eating/drinking_beha0.94223690
72MP0000013_abnormal_adipose_tissue0.93975263
73MP0006276_abnormal_autonomic_nervous0.91198052
74MP0003123_paternal_imprinting0.90762883
75MP0001851_eye_inflammation0.89348919
76MP0003283_abnormal_digestive_organ0.89332637
77MP0004947_skin_inflammation0.89194601
78MP0000604_amyloidosis0.88946051
79MP0004145_abnormal_muscle_electrophysio0.88270648
80MP0002420_abnormal_adaptive_immunity0.88080646
81MP0008877_abnormal_DNA_methylation0.87907613
82MP0000920_abnormal_myelination0.87906105
83MP0005410_abnormal_fertilization0.87649354
84MP0005551_abnormal_eye_electrophysiolog0.87231695
85MP0000751_myopathy0.86360677
86MP0005409_darkened_coat_color0.86261708
87MP0001819_abnormal_immune_cell0.85898102
88MP0001188_hyperpigmentation0.85016204
89MP0005535_abnormal_body_temperature0.84730496
90MP0010234_abnormal_vibrissa_follicle0.84430384
91MP0008260_abnormal_autophagy0.83135308
92MP0002723_abnormal_immune_serum0.82733964
93MP0003632_abnormal_nervous_system0.81406569
94MP0004085_abnormal_heartbeat0.80972925
95MP0004742_abnormal_vestibular_system0.79896610
96MP0002398_abnormal_bone_marrow0.79228666
97MP0005167_abnormal_blood-brain_barrier0.77894049
98MP0002090_abnormal_vision0.75528777
99MP0003634_abnormal_glial_cell0.74646745
100MP0003878_abnormal_ear_physiology0.74518255
101MP0005377_hearing/vestibular/ear_phenot0.74518255
102MP0005394_taste/olfaction_phenotype0.72315971
103MP0005499_abnormal_olfactory_system0.72315971
104MP0001765_abnormal_ion_homeostasis0.70064903
105MP0003303_peritoneal_inflammation0.69826010
106MP0009278_abnormal_bone_marrow0.68579610
107MP0005025_abnormal_response_to0.68310755
108MP0000716_abnormal_immune_system0.67292862
109MP0001873_stomach_inflammation0.67170259
110MP0009333_abnormal_splenocyte_physiolog0.66037956
111MP0001963_abnormal_hearing_physiology0.65152389
112MP0004381_abnormal_hair_follicle0.63655377
113MP0002419_abnormal_innate_immunity0.62550697
114MP0003183_abnormal_peptide_metabolism0.62350640
115MP0003172_abnormal_lysosome_physiology0.61917920
116MP0000631_abnormal_neuroendocrine_gland0.61865924
117MP0003122_maternal_imprinting0.61174970
118MP0006082_CNS_inflammation0.59268422
119MP0002752_abnormal_somatic_nervous0.58279423
120MP0003137_abnormal_impulse_conducting0.54863505
121MP0004484_altered_response_of0.54349659
122MP0001664_abnormal_digestion0.53302479
123MP0010769_abnormal_survival0.52716585
124MP0001943_abnormal_respiration0.51711208
125MP0010386_abnormal_urinary_bladder0.51631318
126MP0004233_abnormal_muscle_weight0.51555728
127MP0005166_decreased_susceptibility_to0.50426831
128MP0003956_abnormal_body_size0.50165463
129MP0001485_abnormal_pinna_reflex0.49955627
130MP0003045_fibrosis0.49854378
131MP0010768_mortality/aging0.49344290
132MP0002082_postnatal_lethality0.48444728
133MP0010770_preweaning_lethality0.48444728
134MP0004043_abnormal_pH_regulation0.48182876

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.82714414
2Focal motor seizures (HP:0011153)7.81924979
3Focal seizures (HP:0007359)6.00923286
4Visual hallucinations (HP:0002367)5.32598509
5Epileptic encephalopathy (HP:0200134)4.73524197
6Action tremor (HP:0002345)4.50066933
7Febrile seizures (HP:0002373)4.45687578
8Atonic seizures (HP:0010819)4.36341944
9Progressive cerebellar ataxia (HP:0002073)4.22594382
10Absence seizures (HP:0002121)4.10309627
11Poor eye contact (HP:0000817)4.06939830
12Broad-based gait (HP:0002136)3.93184929
13Gaze-evoked nystagmus (HP:0000640)3.81048942
14Generalized tonic-clonic seizures (HP:0002069)3.80640928
15Abnormal social behavior (HP:0012433)3.70376416
16Impaired social interactions (HP:0000735)3.70376416
17Dialeptic seizures (HP:0011146)3.68742358
18Ankle clonus (HP:0011448)3.67473696
19Papilledema (HP:0001085)3.61722124
20Impaired vibration sensation in the lower limbs (HP:0002166)3.58195674
21Supranuclear gaze palsy (HP:0000605)3.51686205
22Dysdiadochokinesis (HP:0002075)3.51526590
23Urinary bladder sphincter dysfunction (HP:0002839)3.48868405
24Depression (HP:0000716)3.48076574
25Postural instability (HP:0002172)3.36969148
26Dysmetria (HP:0001310)3.33566577
27Slow saccadic eye movements (HP:0000514)3.30683135
28Impaired smooth pursuit (HP:0007772)3.20433440
29Anxiety (HP:0000739)3.20337945
30Truncal ataxia (HP:0002078)3.18629198
31Eczematoid dermatitis (HP:0000976)3.12692373
32Torticollis (HP:0000473)3.09521113
33Mutism (HP:0002300)3.05471027
34Urinary urgency (HP:0000012)3.01487449
35Dysmetric saccades (HP:0000641)2.98126932
36Scanning speech (HP:0002168)2.95217115
37Hemiplegia (HP:0002301)2.92481395
38Peripheral hypomyelination (HP:0007182)2.92224476
39Hyperventilation (HP:0002883)2.91977413
40Resting tremor (HP:0002322)2.88293588
41Abnormality of the lower motor neuron (HP:0002366)2.88151490
42Intention tremor (HP:0002080)2.88054419
43Annular pancreas (HP:0001734)2.87744947
44Stereotypic behavior (HP:0000733)2.82298891
45Abnormal eating behavior (HP:0100738)2.81871613
46Abnormality of ocular smooth pursuit (HP:0000617)2.81189098
47Genetic anticipation (HP:0003743)2.80613020
48Spastic gait (HP:0002064)2.78891599
49Focal dystonia (HP:0004373)2.77785661
50Amblyopia (HP:0000646)2.75300671
51Delusions (HP:0000746)2.74028838
52Abnormality of binocular vision (HP:0011514)2.63192792
53Diplopia (HP:0000651)2.63192792
54Stomatitis (HP:0010280)2.62055320
55Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.61889282
56Hemiparesis (HP:0001269)2.61403670
57Bradykinesia (HP:0002067)2.61317421
58Pustule (HP:0200039)2.57563803
59Drooling (HP:0002307)2.55500944
60Excessive salivation (HP:0003781)2.55500944
61Progressive inability to walk (HP:0002505)2.53787636
62Ventricular fibrillation (HP:0001663)2.53701282
63Craniofacial dystonia (HP:0012179)2.53138479
64Status epilepticus (HP:0002133)2.51672074
65Impaired vibratory sensation (HP:0002495)2.48361131
66Pointed chin (HP:0000307)2.44100231
67Spinal canal stenosis (HP:0003416)2.42705384
68T lymphocytopenia (HP:0005403)2.39221806
69Cerebral hypomyelination (HP:0006808)2.37276994
70Megalencephaly (HP:0001355)2.35460436
71Ankyloglossia (HP:0010296)2.31565670
72Sleep apnea (HP:0010535)2.28932975
73Epileptiform EEG discharges (HP:0011182)2.27786334
74Neurofibrillary tangles (HP:0002185)2.25585477
75Lower limb amyotrophy (HP:0007210)2.24672301
76Cerebral inclusion bodies (HP:0100314)2.20473581
77Lower limb muscle weakness (HP:0007340)2.19653863
78EEG with generalized epileptiform discharges (HP:0011198)2.19528367
79Termporal pattern (HP:0011008)2.16550653
80Insidious onset (HP:0003587)2.16550653
81Fetal akinesia sequence (HP:0001989)2.16406364
82Abnormality of the corticospinal tract (HP:0002492)2.13322758
83Clonus (HP:0002169)2.12836536
84Absent speech (HP:0001344)2.12192368
85Akinesia (HP:0002304)2.11686619
86Bundle branch block (HP:0011710)2.10092077
87Abnormality of saccadic eye movements (HP:0000570)2.09965700
88Ocular albinism (HP:0001107)2.09589574
89Myositis (HP:0100614)2.09251892
90Hypsarrhythmia (HP:0002521)2.08428164
91Elevated erythrocyte sedimentation rate (HP:0003565)2.08333443
92Inability to walk (HP:0002540)2.06857050
93Insomnia (HP:0100785)2.05009222
94Abnormality of T cell number (HP:0011839)2.02144351
95Amyotrophic lateral sclerosis (HP:0007354)2.01726517
96Incomplete penetrance (HP:0003829)2.01591469
97Obstructive sleep apnea (HP:0002870)2.01438945
98Neuronal loss in central nervous system (HP:0002529)2.00491537
99Gait ataxia (HP:0002066)2.00123317
100Inappropriate behavior (HP:0000719)1.99764814
101Abnormality of the fingertips (HP:0001211)1.98184700
102Generalized myoclonic seizures (HP:0002123)1.97902460
103Lower limb asymmetry (HP:0100559)1.93991884
104Abnormal EKG (HP:0003115)1.91891159
105Memory impairment (HP:0002354)1.91417221
106Iris hypopigmentation (HP:0007730)1.89854729
107Abnormality of the periventricular white matter (HP:0002518)1.89580229
108Rigidity (HP:0002063)1.87345335
109Limb dystonia (HP:0002451)1.85547519
110Hypochromic microcytic anemia (HP:0004840)1.85441113
111Tetraplegia (HP:0002445)1.84434190
112Diminished motivation (HP:0000745)1.83248510
113Psychosis (HP:0000709)1.81332833
114Aqueductal stenosis (HP:0002410)1.80853618
115Recurrent bacterial skin infections (HP:0005406)1.77572370
116Abnormality of salivation (HP:0100755)1.77527529
117Blue irides (HP:0000635)1.76485919
118Prolonged QT interval (HP:0001657)1.75695446
119Bowel incontinence (HP:0002607)1.74424380
120Hypochromic anemia (HP:0001931)1.72458082
121Retrobulbar optic neuritis (HP:0100654)1.70515636
122Optic neuritis (HP:0100653)1.70515636
123Increased circulating renin level (HP:0000848)1.70474853
124Agitation (HP:0000713)1.69793765
125Apathy (HP:0000741)1.69478900
126Abnormality of oral frenula (HP:0000190)1.69246812
127Global brain atrophy (HP:0002283)1.68748899
128Rapidly progressive (HP:0003678)1.67971968
129Degeneration of the lateral corticospinal tracts (HP:0002314)1.67190505
130Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.67190505
131Spastic tetraparesis (HP:0001285)1.66257193

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.29061708
2MAP3K94.25752031
3NTRK34.17370216
4DAPK23.08210967
5RIPK42.68489533
6MARK12.66089825
7MAP3K42.57453077
8MINK12.43029667
9KSR22.36987528
10PRKD32.33173225
11PAK62.31392152
12CAMKK12.21939851
13NTRK22.14217439
14MAP4K11.99045186
15MAP2K71.90626988
16SIK21.90410145
17NTRK11.88740565
18MAP3K131.83157225
19DAPK11.69819924
20CDK51.60920832
21MAP2K41.59775199
22TAOK11.53762591
23FES1.49671874
24KSR11.49394921
25STK381.48561413
26PRPF4B1.31901925
27MAP3K121.28865971
28MAP3K21.28766789
29CAMKK21.28281533
30TYRO31.22593676
31GRK51.21784699
32ARAF1.21003512
33CDK191.20690272
34JAK11.15475672
35TNIK1.14628739
36TXK1.13649492
37STK111.11981942
38MAPK131.11760445
39PRKCH1.08188228
40PRKCG1.04947838
41ZAP701.03330833
42MAP3K111.02983200
43ITK1.02307982
44PLK21.02008897
45ALK1.01078970
46UHMK11.00004622
47CAMK10.99886068
48TNK20.94954356
49SIK30.93661244
50RIPK10.92878525
51TYK20.92484436
52RAF10.91603346
53SGK2230.89276426
54SGK4940.89276426
55TAOK30.89135473
56BMPR20.89028745
57CASK0.88930918
58SGK30.85244889
59PDK10.85143104
60CDK150.85021552
61CDK180.83923349
62MARK20.83635720
63PNCK0.83445559
64SGK20.83231181
65RET0.80071112
66JAK20.79154929
67CAMK2A0.78386117
68SGK10.76484127
69CDK140.75950574
70PDPK10.74438385
71CDK11A0.74256402
72PHKG20.73976297
73PHKG10.73976297
74PINK10.73697427
75FGFR20.70470549
76HCK0.68867697
77CDC42BPA0.67853060
78LATS20.66751983
79CAMK2B0.65892409
80PTK2B0.65276976
81WNK10.62827666
82FGFR30.60404962
83MAP3K10.60154273
84BTK0.59995292
85TRIB30.58631839
86CAMK1G0.58318275
87LCK0.57988483
88FYN0.57983660
89MAP3K70.57928186
90DYRK1A0.55616861
91LMTK20.54288800
92RPS6KA30.54186213
93FGFR40.53108733
94CAMK40.52339878
95PAK30.51893608
96MAPK70.51539915
97PRKD20.51433570
98DAPK30.50662843
99CSNK1G20.49968432
100PRKCZ0.49958872
101HIPK20.48262553
102MAPK100.46518043
103CSK0.45909111
104IKBKE0.45905959
105OXSR10.45756756
106CCNB10.44866570
107CDK120.44652574
108SCYL20.44637199
109MAPK120.44280469
110PRKCQ0.43872320
111NEK60.42876767
112JAK30.42312452
113BRSK10.41718571
114MAP2K60.41589079
115MAP2K10.41115542
116SIK10.39522114
117NLK0.39473733
118DYRK1B0.38952533
119DMPK0.36910445
120PRKCB0.33577135
121GRK60.32348641
122NEK10.32121079
123FGR0.31276250
124PRKCE0.30311607
125CAMK2G0.29517805
126SYK0.27267311
127MAPK80.25777338
128CAMK2D0.25547125

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.40525047
2Synaptic vesicle cycle_Homo sapiens_hsa047213.01447982
3Olfactory transduction_Homo sapiens_hsa047402.96472071
4Long-term potentiation_Homo sapiens_hsa047202.75231915
5Glutamatergic synapse_Homo sapiens_hsa047242.65165867
6* Circadian entrainment_Homo sapiens_hsa047132.64734975
7GABAergic synapse_Homo sapiens_hsa047272.64462725
8Morphine addiction_Homo sapiens_hsa050322.60852969
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.55896728
10Amphetamine addiction_Homo sapiens_hsa050312.44026530
11Salivary secretion_Homo sapiens_hsa049702.25844977
12Dopaminergic synapse_Homo sapiens_hsa047282.15028645
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.13238336
14Cholinergic synapse_Homo sapiens_hsa047251.97862143
15Gastric acid secretion_Homo sapiens_hsa049711.97468921
16Insulin secretion_Homo sapiens_hsa049111.96683286
17* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.87595863
18Renin secretion_Homo sapiens_hsa049241.74761013
19Oxytocin signaling pathway_Homo sapiens_hsa049211.74273635
20Cocaine addiction_Homo sapiens_hsa050301.73887722
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72036551
22Long-term depression_Homo sapiens_hsa047301.68573198
23Taste transduction_Homo sapiens_hsa047421.60370212
24* Calcium signaling pathway_Homo sapiens_hsa040201.56446901
25GnRH signaling pathway_Homo sapiens_hsa049121.53880109
26T cell receptor signaling pathway_Homo sapiens_hsa046601.53046851
27Serotonergic synapse_Homo sapiens_hsa047261.45970385
28Nitrogen metabolism_Homo sapiens_hsa009101.42485646
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40972650
30Gap junction_Homo sapiens_hsa045401.37931020
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.37011655
32cAMP signaling pathway_Homo sapiens_hsa040241.32286035
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.31880317
34Type II diabetes mellitus_Homo sapiens_hsa049301.27085891
35Glioma_Homo sapiens_hsa052141.23367417
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20953597
37Estrogen signaling pathway_Homo sapiens_hsa049151.20609769
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20063064
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10683016
40ErbB signaling pathway_Homo sapiens_hsa040121.03548160
41Osteoclast differentiation_Homo sapiens_hsa043801.02389144
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99241630
43Phospholipase D signaling pathway_Homo sapiens_hsa040720.97848824
44Primary immunodeficiency_Homo sapiens_hsa053400.97543627
45Melanogenesis_Homo sapiens_hsa049160.96358296
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.94568185
47Pancreatic secretion_Homo sapiens_hsa049720.93250988
48Axon guidance_Homo sapiens_hsa043600.92199328
49Acute myeloid leukemia_Homo sapiens_hsa052210.91411550
50Dorso-ventral axis formation_Homo sapiens_hsa043200.89633422
51Collecting duct acid secretion_Homo sapiens_hsa049660.88799962
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85996078
53Oocyte meiosis_Homo sapiens_hsa041140.85116997
54Phototransduction_Homo sapiens_hsa047440.84975558
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82851523
56Thyroid hormone synthesis_Homo sapiens_hsa049180.82830539
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.77937434
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77193558
59Cardiac muscle contraction_Homo sapiens_hsa042600.76504350
60* MAPK signaling pathway_Homo sapiens_hsa040100.76482614
61Choline metabolism in cancer_Homo sapiens_hsa052310.75700073
62VEGF signaling pathway_Homo sapiens_hsa043700.75425550
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74822685
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74177232
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74167514
66Dilated cardiomyopathy_Homo sapiens_hsa054140.71777882
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71045016
68Non-small cell lung cancer_Homo sapiens_hsa052230.68070960
69mTOR signaling pathway_Homo sapiens_hsa041500.66592477
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66024142
71B cell receptor signaling pathway_Homo sapiens_hsa046620.64087773
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63963561
73Rap1 signaling pathway_Homo sapiens_hsa040150.62517365
74Chemokine signaling pathway_Homo sapiens_hsa040620.60155676
75Prolactin signaling pathway_Homo sapiens_hsa049170.59965076
76Inositol phosphate metabolism_Homo sapiens_hsa005620.58591176
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.57086996
78Glucagon signaling pathway_Homo sapiens_hsa049220.56933507
79Colorectal cancer_Homo sapiens_hsa052100.56933226
80Endocytosis_Homo sapiens_hsa041440.56603684
81Ras signaling pathway_Homo sapiens_hsa040140.55333665
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55125574
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.54943897
84Alcoholism_Homo sapiens_hsa050340.54362152
85Bile secretion_Homo sapiens_hsa049760.54193114
86Vitamin B6 metabolism_Homo sapiens_hsa007500.51536280
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51070889
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50647002
89Vibrio cholerae infection_Homo sapiens_hsa051100.50025797
90HIF-1 signaling pathway_Homo sapiens_hsa040660.49914584
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49522006
92Tuberculosis_Homo sapiens_hsa051520.48968540
93Endometrial cancer_Homo sapiens_hsa052130.48935892
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47199414
95FoxO signaling pathway_Homo sapiens_hsa040680.46931799
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.46785258
97Type I diabetes mellitus_Homo sapiens_hsa049400.46640763
98Renal cell carcinoma_Homo sapiens_hsa052110.46055867
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46004900
100Toll-like receptor signaling pathway_Homo sapiens_hsa046200.45822766
101African trypanosomiasis_Homo sapiens_hsa051430.44387021
102Chronic myeloid leukemia_Homo sapiens_hsa052200.44247578
103Regulation of autophagy_Homo sapiens_hsa041400.44179577
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44034594
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43616397
106Platelet activation_Homo sapiens_hsa046110.43448947
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41913679
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41046200
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40735577
110Circadian rhythm_Homo sapiens_hsa047100.40506336
111Insulin signaling pathway_Homo sapiens_hsa049100.40296102
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39983442
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38012666
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33838026
115Prion diseases_Homo sapiens_hsa050200.31397275
116Wnt signaling pathway_Homo sapiens_hsa043100.31243218
117Ovarian steroidogenesis_Homo sapiens_hsa049130.31038446
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28325948

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