CACNA2D1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)5.77956791
2muscle filament sliding (GO:0030049)5.77956791
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.02229912
4actin-mediated cell contraction (GO:0070252)4.92847627
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.64210365
6vocalization behavior (GO:0071625)4.57014549
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.44194605
8neuron cell-cell adhesion (GO:0007158)4.42565462
9synaptic vesicle exocytosis (GO:0016079)4.35003223
10protein localization to synapse (GO:0035418)4.23887218
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.20296951
12locomotory exploration behavior (GO:0035641)4.16529336
13synaptic vesicle maturation (GO:0016188)4.14509191
14neuronal action potential propagation (GO:0019227)4.14089752
15glutamate secretion (GO:0014047)4.12670624
16myofibril assembly (GO:0030239)4.12499886
17regulation of synaptic vesicle exocytosis (GO:2000300)4.12331097
18regulation of glutamate receptor signaling pathway (GO:1900449)4.08878806
19skeletal muscle contraction (GO:0003009)4.05807700
20regulation of skeletal muscle contraction (GO:0014819)3.98730249
21neuron recognition (GO:0008038)3.96401151
22ionotropic glutamate receptor signaling pathway (GO:0035235)3.88555566
23regulation of relaxation of muscle (GO:1901077)3.80384720
24synaptic vesicle docking involved in exocytosis (GO:0016081)3.80253928
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.79903227
26actin filament-based movement (GO:0030048)3.76955613
27cardiac myofibril assembly (GO:0055003)3.76778158
28striated muscle contraction (GO:0006941)3.75467440
29sarcomere organization (GO:0045214)3.75087057
30layer formation in cerebral cortex (GO:0021819)3.74804244
31axonal fasciculation (GO:0007413)3.72916439
32exploration behavior (GO:0035640)3.71362392
33regulation of synaptic vesicle transport (GO:1902803)3.71343347
34glutamate receptor signaling pathway (GO:0007215)3.70195084
35positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.61342470
36response to inactivity (GO:0014854)3.60984159
37positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.58560205
38regulation of neuronal synaptic plasticity (GO:0048168)3.57125717
39regulation of long-term neuronal synaptic plasticity (GO:0048169)3.53535374
40detection of calcium ion (GO:0005513)3.51403336
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.50107079
42dendritic spine morphogenesis (GO:0060997)3.48185676
43regulation of synapse structural plasticity (GO:0051823)3.44202690
44synaptic transmission, glutamatergic (GO:0035249)3.43427639
45regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.41171129
46neuron-neuron synaptic transmission (GO:0007270)3.35005560
47postsynaptic membrane organization (GO:0001941)3.33572719
48cardiac muscle contraction (GO:0060048)3.31673534
49response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.31398457
50sarcoplasmic reticulum calcium ion transport (GO:0070296)3.30749612
51activation of protein kinase A activity (GO:0034199)3.28965925
52skeletal muscle fiber development (GO:0048741)3.28666758
53neurotransmitter secretion (GO:0007269)3.25513305
54presynaptic membrane assembly (GO:0097105)3.25037844
55gamma-aminobutyric acid signaling pathway (GO:0007214)3.24177948
56regulation of excitatory postsynaptic membrane potential (GO:0060079)3.23383143
57regulation of postsynaptic membrane potential (GO:0060078)3.19743297
58plasma membrane repair (GO:0001778)3.19000394
59regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.18922320
60positive regulation of synapse maturation (GO:0090129)3.18750137
61membrane depolarization during action potential (GO:0086010)3.18400723
62presynaptic membrane organization (GO:0097090)3.17226142
63negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.16070456
64regulation of dendritic spine morphogenesis (GO:0061001)3.14080814
65regulation of cell communication by electrical coupling (GO:0010649)3.13130786
66regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.12835535
67synaptic vesicle endocytosis (GO:0048488)3.12624108
68regulation of actin filament-based movement (GO:1903115)3.12418176
69cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.11577926
70myotube cell development (GO:0014904)3.10730810
71neurotransmitter-gated ion channel clustering (GO:0072578)3.10020789
72actomyosin structure organization (GO:0031032)3.09983536
73long-term memory (GO:0007616)3.09015020
74proline transport (GO:0015824)3.05968620
75regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.05765435
76transmission of nerve impulse (GO:0019226)3.05150464
77muscle contraction (GO:0006936)3.03408527
78innervation (GO:0060384)3.02999277
79cell communication by electrical coupling (GO:0010644)3.02875099
80pyrimidine nucleobase catabolic process (GO:0006208)2.99688237
81cellular potassium ion homeostasis (GO:0030007)2.99214518
82response to muscle activity (GO:0014850)2.98182345
83regulation of vesicle fusion (GO:0031338)2.97161039
84regulation of synaptic plasticity (GO:0048167)2.96899300
85dendrite morphogenesis (GO:0048813)2.96658452
86cardiac muscle hypertrophy (GO:0003300)2.96202292
87positive regulation of synaptic transmission, GABAergic (GO:0032230)2.95492701
88regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.95411094
89behavioral defense response (GO:0002209)2.94800444
90behavioral fear response (GO:0001662)2.94800444
91regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.94670719
92regulation of membrane repolarization (GO:0060306)2.94207175
93muscle fiber development (GO:0048747)2.93874696
94chemosensory behavior (GO:0007635)2.92296194
95fear response (GO:0042596)2.89910664
96negative regulation of potassium ion transmembrane transport (GO:1901380)2.88791693
97negative regulation of cytosolic calcium ion concentration (GO:0051481)2.88218886
98regulation of synaptic transmission, glutamatergic (GO:0051966)2.88178258
99auditory behavior (GO:0031223)2.87510062
100regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.87273855
101positive regulation of potassium ion transmembrane transport (GO:1901381)2.87099192
102membrane depolarization (GO:0051899)2.86705274
103vesicle transport along microtubule (GO:0047496)2.86646743
104negative regulation of synaptic transmission, GABAergic (GO:0032229)2.86400459
105positive regulation of membrane potential (GO:0045838)2.83565115
106regulation of dendritic spine development (GO:0060998)2.82811399
107myotube differentiation (GO:0014902)2.81948954
108cell migration in hindbrain (GO:0021535)2.81923865
109cerebellar Purkinje cell differentiation (GO:0021702)2.81785829
110G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.81775731
111striated muscle hypertrophy (GO:0014897)2.81468864
112regulation of neurotransmitter secretion (GO:0046928)2.81010247
113G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.80697296
114positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.80312240
115regulation of calcium ion transmembrane transporter activity (GO:1901019)2.77636557
116regulation of calcium ion transmembrane transport (GO:1903169)2.77636557
117long-term synaptic potentiation (GO:0060291)2.76003468
118neurotransmitter transport (GO:0006836)2.74419656
119neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.74264418
120dendritic spine organization (GO:0097061)2.74122555
121organelle transport along microtubule (GO:0072384)2.72220346
122positive regulation of neurotransmitter secretion (GO:0001956)2.72118105
123positive regulation of dendritic spine development (GO:0060999)2.71703591
124synapse assembly (GO:0007416)2.71520486
125muscle system process (GO:0003012)2.70659952
126neuromuscular synaptic transmission (GO:0007274)2.69883574
127muscle cell cellular homeostasis (GO:0046716)2.69739839
128neuronal ion channel clustering (GO:0045161)2.68932074
129positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.68712528
130axon extension (GO:0048675)2.68449872
131synapse organization (GO:0050808)2.68405782
132regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.67396235
133myoblast fusion (GO:0007520)2.67257770
134regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.67113336
135learning (GO:0007612)2.66842729
136gamma-aminobutyric acid transport (GO:0015812)2.64794983
137cochlea development (GO:0090102)2.64777695
138central nervous system projection neuron axonogenesis (GO:0021952)2.64172301
139cerebellar granule cell differentiation (GO:0021707)2.60005520
140negative regulation of protein localization to cell surface (GO:2000009)2.53392591
141regulation of potassium ion transmembrane transporter activity (GO:1901016)2.47502583
142positive regulation of potassium ion transport (GO:0043268)2.45979957
143startle response (GO:0001964)2.43534937
144establishment of mitochondrion localization (GO:0051654)2.43098473
145nucleobase catabolic process (GO:0046113)2.42626725
146regulation of striated muscle contraction (GO:0006942)2.42018995
147skeletal muscle tissue development (GO:0007519)2.41381561
148regulation of sarcomere organization (GO:0060297)2.40816971
149regulation of cAMP-dependent protein kinase activity (GO:2000479)2.39603833
150creatine metabolic process (GO:0006600)2.39285120
151cell communication involved in cardiac conduction (GO:0086065)2.37355765

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.97841089
2GBX2_23144817_ChIP-Seq_PC3_Human3.73003401
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95695345
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.88470550
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87629914
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55384159
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55384159
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.53295620
9* EZH2_27304074_Chip-Seq_ESCs_Mouse2.49868983
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48825503
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45494180
12* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42539636
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41921758
14REST_21632747_ChIP-Seq_MESCs_Mouse2.36830795
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32942471
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.32055625
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28921285
18DROSHA_22980978_ChIP-Seq_HELA_Human2.09548441
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.09393369
20* RNF2_27304074_Chip-Seq_ESCs_Mouse2.05327381
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.03877109
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03077230
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90244655
24TAF15_26573619_Chip-Seq_HEK293_Human1.87609491
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.86997901
26AR_21572438_ChIP-Seq_LNCaP_Human1.86322637
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85735454
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82028780
29ZNF274_21170338_ChIP-Seq_K562_Hela1.76507666
30SMAD4_21799915_ChIP-Seq_A2780_Human1.75552545
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72348887
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69131032
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67939965
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62631175
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62242277
36* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59252512
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.52432093
38* P300_19829295_ChIP-Seq_ESCs_Human1.51570949
39NR3C1_23031785_ChIP-Seq_PC12_Mouse1.49666591
40* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48543193
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.48464529
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46451435
43* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45000269
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44171841
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42289250
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39954246
47HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.39097790
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.38779588
49* SOX2_21211035_ChIP-Seq_LN229_Gbm1.38747625
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38559373
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.38466949
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38448127
53* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38440603
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38214127
55WT1_19549856_ChIP-ChIP_CCG9911_Human1.36899916
56IGF1R_20145208_ChIP-Seq_DFB_Human1.35295222
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.33214748
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31791758
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31729785
60AR_25329375_ChIP-Seq_VCAP_Human1.31407032
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30129626
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28614091
63* STAT3_23295773_ChIP-Seq_U87_Human1.28335365
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27835729
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23922308
66FUS_26573619_Chip-Seq_HEK293_Human1.23445450
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.22011362
68VDR_22108803_ChIP-Seq_LS180_Human1.21657456
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20536365
70EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20193668
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18680587
72AR_19668381_ChIP-Seq_PC3_Human1.17073735
73* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16293113
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.16277782
75RNF2_27304074_Chip-Seq_NSC_Mouse1.15276273
76* TCF4_23295773_ChIP-Seq_U87_Human1.12112556
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.12072361
78LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12014807
79AHR_22903824_ChIP-Seq_MCF-7_Human1.11414277
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10929974
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10703578
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.10069016
83SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09914663
84TP53_20018659_ChIP-ChIP_R1E_Mouse1.09659994
85* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09022340
86* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08223231
87* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08223231
88* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07855778
89TP53_18474530_ChIP-ChIP_U2OS_Human1.07690104
90WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07086162
91ISL1_27105846_Chip-Seq_CPCs_Mouse1.06036401
92* RING1B_27294783_Chip-Seq_NPCs_Mouse1.05299466
93RUNX2_22187159_ChIP-Seq_PCA_Human1.05193833
94TP53_16413492_ChIP-PET_HCT116_Human1.05134649
95* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05078373
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04375168
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04304462
98SOX9_26525672_Chip-Seq_HEART_Mouse1.03940694
99P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03553317
100SMAD3_21741376_ChIP-Seq_HESCs_Human1.03056740
101* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02459302
102BCAT_22108803_ChIP-Seq_LS180_Human0.99643418
103* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99491078
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98812551
105STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98411404
106PRDM14_20953172_ChIP-Seq_ESCs_Human0.96763921
107* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96611947
108KDM2B_26808549_Chip-Seq_REH_Human0.96162286
109* ER_23166858_ChIP-Seq_MCF-7_Human0.95943906
110RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95694887
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95225579
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95225579
113NANOG_18555785_Chip-Seq_ESCs_Mouse0.94157263
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92482495
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92425348
116SMAD4_21741376_ChIP-Seq_HESCs_Human0.92287261
117* SMAD3_21741376_ChIP-Seq_ESCs_Human0.91766169
118JUN_21703547_ChIP-Seq_K562_Human0.91445861
119* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91207928
120* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90765139

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.15458109
2MP0003880_abnormal_central_pattern4.51366995
3MP0004270_analgesia3.90543462
4* MP0003635_abnormal_synaptic_transmissio3.46739051
5MP0002063_abnormal_learning/memory/cond2.85685373
6MP0001968_abnormal_touch/_nociception2.83008255
7* MP0009745_abnormal_behavioral_response2.76167867
8MP0002837_dystrophic_cardiac_calcinosis2.65836281
9MP0002734_abnormal_mechanical_nocicepti2.53799326
10MP0002735_abnormal_chemical_nociception2.48921411
11MP0002064_seizures2.45691799
12MP0002572_abnormal_emotion/affect_behav2.37984265
13MP0000751_myopathy2.35211166
14MP0005423_abnormal_somatic_nervous2.34702887
15MP0006276_abnormal_autonomic_nervous2.26023005
16MP0009780_abnormal_chondrocyte_physiolo2.24772647
17MP0009046_muscle_twitch2.24743285
18MP0001440_abnormal_grooming_behavior2.16722370
19MP0002272_abnormal_nervous_system2.15317259
20* MP0004145_abnormal_muscle_electrophysio2.04395388
21MP0002736_abnormal_nociception_after2.04347368
22MP0001486_abnormal_startle_reflex1.99725016
23MP0002733_abnormal_thermal_nociception1.97316984
24MP0001501_abnormal_sleep_pattern1.92651229
25MP0002909_abnormal_adrenal_gland1.87884427
26MP0002184_abnormal_innervation1.86536110
27MP0000778_abnormal_nervous_system1.85897000
28MP0001970_abnormal_pain_threshold1.83339359
29MP0002067_abnormal_sensory_capabilities1.81935448
30MP0004858_abnormal_nervous_system1.70167462
31MP0010386_abnormal_urinary_bladder1.62126609
32MP0000750_abnormal_muscle_regeneration1.60952215
33MP0005645_abnormal_hypothalamus_physiol1.54751452
34MP0003329_amyloid_beta_deposits1.54369928
35MP0002557_abnormal_social/conspecific_i1.54130675
36MP0004924_abnormal_behavior1.53916982
37MP0005386_behavior/neurological_phenoty1.53916982
38MP0005646_abnormal_pituitary_gland1.51346551
39MP0008438_abnormal_cutaneous_collagen1.49861749
40MP0004811_abnormal_neuron_physiology1.47614898
41MP0004215_abnormal_myocardial_fiber1.43441675
42MP0003122_maternal_imprinting1.43040629
43MP0000749_muscle_degeneration1.42914699
44MP0000955_abnormal_spinal_cord1.42713005
45MP0000013_abnormal_adipose_tissue1.42233686
46MP0008569_lethality_at_weaning1.40870440
47MP0001984_abnormal_olfaction1.40534317
48MP0002822_catalepsy1.39080937
49MP0002332_abnormal_exercise_endurance1.37784960
50MP0004036_abnormal_muscle_relaxation1.30234261
51MP0003646_muscle_fatigue1.28319231
52MP0004484_altered_response_of1.27065254
53MP0002882_abnormal_neuron_morphology1.26830246
54MP0002066_abnormal_motor_capabilities/c1.24471519
55MP0003879_abnormal_hair_cell1.24328483
56MP0000733_abnormal_muscle_development1.22407911
57MP0000747_muscle_weakness1.21179847
58MP0001188_hyperpigmentation1.20020967
59MP0003787_abnormal_imprinting1.17792892
60MP0004085_abnormal_heartbeat1.16276963
61MP0001529_abnormal_vocalization1.14080439
62* MP0005620_abnormal_muscle_contractility1.09997685
63MP0001502_abnormal_circadian_rhythm1.09784436
64MP0004233_abnormal_muscle_weight1.07267069
65MP0005503_abnormal_tendon_morphology1.05495032
66MP0003137_abnormal_impulse_conducting1.04602274
67MP0001299_abnormal_eye_distance/1.04429737
68MP0003633_abnormal_nervous_system1.03551592
69MP0003283_abnormal_digestive_organ1.01858683
70MP0006138_congestive_heart_failure1.00755798
71MP0004134_abnormal_chest_morphology1.00186337
72MP0002127_abnormal_cardiovascular_syste0.99675497
73MP0001905_abnormal_dopamine_level0.99097434
74MP0000759_abnormal_skeletal_muscle0.99094618
75* MP0002106_abnormal_muscle_physiology0.98939794
76MP0003121_genomic_imprinting0.98811781
77MP0004885_abnormal_endolymph0.98031676
78MP0005623_abnormal_meninges_morphology0.95225455
79MP0002234_abnormal_pharynx_morphology0.94652330
80MP0002152_abnormal_brain_morphology0.94171358
81MP0003123_paternal_imprinting0.93304016
82MP0005187_abnormal_penis_morphology0.91986566
83MP0000631_abnormal_neuroendocrine_gland0.91521049
84MP0000534_abnormal_ureter_morphology0.91381025
85* MP0005369_muscle_phenotype0.90838543
86MP0004130_abnormal_muscle_cell0.90259256
87MP0003385_abnormal_body_wall0.88933419
88MP0004142_abnormal_muscle_tone0.85079071
89MP0004087_abnormal_muscle_fiber0.84408095
90MP0003631_nervous_system_phenotype0.84356093
91MP0010630_abnormal_cardiac_muscle0.84330453
92MP0002069_abnormal_eating/drinking_beha0.84007740
93MP0008775_abnormal_heart_ventricle0.83489217
94MP0005275_abnormal_skin_tensile0.82866964
95MP0005535_abnormal_body_temperature0.80949151
96MP0004084_abnormal_cardiac_muscle0.80329281
97MP0000569_abnormal_digit_pigmentation0.79035831
98MP0006072_abnormal_retinal_apoptosis0.78381195
99MP0001544_abnormal_cardiovascular_syste0.78358810
100MP0005385_cardiovascular_system_phenoty0.78358810
101MP0002269_muscular_atrophy0.77650553
102MP0008961_abnormal_basal_metabolism0.77583726
103MP0004043_abnormal_pH_regulation0.76667635
104MP0002971_abnormal_brown_adipose0.75643315
105MP0009250_abnormal_appendicular_skeleto0.75182707
106MP0002229_neurodegeneration0.73917117
107MP0002752_abnormal_somatic_nervous0.72813080
108MP0001958_emphysema0.72607824
109MP0004742_abnormal_vestibular_system0.72423339
110MP0002876_abnormal_thyroid_physiology0.71499792
111MP0004272_abnormal_basement_membrane0.70660509
112MP0005379_endocrine/exocrine_gland_phen0.68471903
113* MP0002972_abnormal_cardiac_muscle0.68275629
114MP0001963_abnormal_hearing_physiology0.67769046
115MP0004510_myositis0.67443396
116MP0003634_abnormal_glial_cell0.67015967
117MP0002108_abnormal_muscle_morphology0.65909826
118MP0002751_abnormal_autonomic_nervous0.65335820
119MP0005551_abnormal_eye_electrophysiolog0.65144738
120MP0005330_cardiomyopathy0.63180349
121MP0002638_abnormal_pupillary_reflex0.61280394
122MP0001943_abnormal_respiration0.60566313

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.37017137
2Focal seizures (HP:0007359)4.64970973
3Visual hallucinations (HP:0002367)4.39074417
4Myokymia (HP:0002411)4.22533531
5Atonic seizures (HP:0010819)4.18298983
6Epileptic encephalopathy (HP:0200134)4.07072839
7Absence seizures (HP:0002121)3.68737276
8Calcaneovalgus deformity (HP:0001848)3.68171939
9Febrile seizures (HP:0002373)3.67416332
10Exercise-induced myalgia (HP:0003738)3.62876270
11Muscle hypertrophy of the lower extremities (HP:0008968)3.60370333
12Broad-based gait (HP:0002136)3.44123439
13Deformed tarsal bones (HP:0008119)3.37174889
14Calf muscle hypertrophy (HP:0008981)3.36220373
15Hyperventilation (HP:0002883)3.35762684
16Dialeptic seizures (HP:0011146)3.34455616
17Generalized tonic-clonic seizures (HP:0002069)3.30435281
18Rimmed vacuoles (HP:0003805)3.28358067
19Ulnar deviation of the wrist (HP:0003049)3.19581814
20Progressive cerebellar ataxia (HP:0002073)3.19469026
21Amblyopia (HP:0000646)2.97193040
22Neck muscle weakness (HP:0000467)2.95735736
23Fetal akinesia sequence (HP:0001989)2.93343955
24Sudden death (HP:0001699)2.92112926
25Subaortic stenosis (HP:0001682)2.91908597
26Abnormality of the left ventricular outflow tract (HP:0011103)2.91908597
27Absent phalangeal crease (HP:0006109)2.91899571
28Myoglobinuria (HP:0002913)2.91667266
29Frequent falls (HP:0002359)2.87357782
30Action tremor (HP:0002345)2.81722305
31Supranuclear gaze palsy (HP:0000605)2.81410790
32Poor eye contact (HP:0000817)2.77382226
33Drooling (HP:0002307)2.77064345
34Excessive salivation (HP:0003781)2.77064345
35Abnormality of the calf musculature (HP:0001430)2.72811941
36Muscle fiber inclusion bodies (HP:0100299)2.70646281
37EMG: neuropathic changes (HP:0003445)2.59582072
38Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.58630132
39Ankle clonus (HP:0011448)2.57125846
40Centrally nucleated skeletal muscle fibers (HP:0003687)2.56619631
41Insidious onset (HP:0003587)2.54401873
42Termporal pattern (HP:0011008)2.54401873
43Truncal ataxia (HP:0002078)2.54149851
44Epileptiform EEG discharges (HP:0011182)2.52950156
45Pheochromocytoma (HP:0002666)2.52078848
46Myotonia (HP:0002486)2.51806142
47Anxiety (HP:0000739)2.49747047
48Mildly elevated creatine phosphokinase (HP:0008180)2.48195613
49Abnormal finger flexion creases (HP:0006143)2.46049919
50Depression (HP:0000716)2.44243516
51Rhabdomyolysis (HP:0003201)2.43318692
52Abnormal social behavior (HP:0012433)2.43308593
53Impaired social interactions (HP:0000735)2.43308593
54Cerebral inclusion bodies (HP:0100314)2.42665367
55Papilledema (HP:0001085)2.42296782
56Impaired vibration sensation in the lower limbs (HP:0002166)2.41769683
57Increased connective tissue (HP:0009025)2.40397593
58Urinary bladder sphincter dysfunction (HP:0002839)2.38965614
59EEG with generalized epileptiform discharges (HP:0011198)2.38952939
60Exercise-induced muscle cramps (HP:0003710)2.37498853
61Agitation (HP:0000713)2.36702966
62Slender build (HP:0001533)2.33780473
63Nemaline bodies (HP:0003798)2.32853289
64Hip contracture (HP:0003273)2.30456990
65Difficulty running (HP:0009046)2.28761822
66Dysdiadochokinesis (HP:0002075)2.28396696
67Gaze-evoked nystagmus (HP:0000640)2.27386965
68Type 1 muscle fiber predominance (HP:0003803)2.25744913
69Absent speech (HP:0001344)2.21840733
70Syncope (HP:0001279)2.21637790
71Neuroendocrine neoplasm (HP:0100634)2.20011096
72Hypsarrhythmia (HP:0002521)2.19906471
73Distal arthrogryposis (HP:0005684)2.19195225
74Genetic anticipation (HP:0003743)2.17572697
75Shoulder girdle muscle weakness (HP:0003547)2.16107443
76Dysmetria (HP:0001310)2.15091286
77Urinary urgency (HP:0000012)2.14774769
78Spinal rigidity (HP:0003306)2.14063403
79Abnormal eating behavior (HP:0100738)2.13806739
80Malignant hyperthermia (HP:0002047)2.13490027
81Prolonged QT interval (HP:0001657)2.12897139
82Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.12785225
83Scapular winging (HP:0003691)2.12662136
84Progressive inability to walk (HP:0002505)2.12324624
85Neurofibrillary tangles (HP:0002185)2.11456842
86EMG: myopathic abnormalities (HP:0003458)2.10635840
87Limited hip movement (HP:0008800)2.10041092
88Lower limb amyotrophy (HP:0007210)2.09228157
89Increased variability in muscle fiber diameter (HP:0003557)2.09121665
90Distal lower limb muscle weakness (HP:0009053)2.07960262
91Asymmetric septal hypertrophy (HP:0001670)2.07756643
92Muscle stiffness (HP:0003552)2.05666329
93Distal lower limb amyotrophy (HP:0008944)2.04869235
94Hyporeflexia of lower limbs (HP:0002600)2.04428318
95Abnormal EKG (HP:0003115)2.02217695
96Areflexia of lower limbs (HP:0002522)2.01486742
97Hemiparesis (HP:0001269)2.01265002
98Hepatoblastoma (HP:0002884)1.99266256
99Limb-girdle muscle atrophy (HP:0003797)1.99035874
100Exotropia (HP:0000577)1.97411332
101Hypoventilation (HP:0002791)1.95376495
102Bundle branch block (HP:0011710)1.95117512
103Lower limb muscle weakness (HP:0007340)1.93119256
104Abnormality of the calcaneus (HP:0008364)1.92799222
105Limb-girdle muscle weakness (HP:0003325)1.92769463
106Inability to walk (HP:0002540)1.92677927
107Impaired smooth pursuit (HP:0007772)1.90912307
108Metatarsus adductus (HP:0001840)1.90150788
109Mutism (HP:0002300)1.89481630
110Gowers sign (HP:0003391)1.89154579
111Abnormality of the corticospinal tract (HP:0002492)1.88872311
112Myopathic facies (HP:0002058)1.88207980
113Generalized muscle weakness (HP:0003324)1.85727098
114Type II lissencephaly (HP:0007260)1.85413577
115Postural instability (HP:0002172)1.85413092
116Ventricular fibrillation (HP:0001663)1.84466645
117Spastic gait (HP:0002064)1.83745689
118Abnormality of skeletal muscle fiber size (HP:0012084)1.83643160
119Abnormality of salivation (HP:0100755)1.83274335
120Scanning speech (HP:0002168)1.82954767
121Proximal amyotrophy (HP:0007126)1.82952255
122Protruding tongue (HP:0010808)1.82744650
123Lipoatrophy (HP:0100578)1.82664628
124Blue irides (HP:0000635)1.82309397
125Retinal dysplasia (HP:0007973)1.80375398
126Overgrowth (HP:0001548)1.79923219
127Ventricular tachycardia (HP:0004756)1.79399215
128Hyperkalemia (HP:0002153)1.79322392
129Muscle fiber splitting (HP:0003555)1.78710424
130Rapidly progressive (HP:0003678)1.78530692
131Stereotypic behavior (HP:0000733)1.78438720
132Aplasia/Hypoplasia of the brainstem (HP:0007362)1.78352158
133Hypoplasia of the brainstem (HP:0002365)1.78352158
134Abnormality of the ischium (HP:0003174)1.77235173
135Heart block (HP:0012722)1.76935991
136Abnormality of the shoulder girdle musculature (HP:0001435)1.75766393
137Abnormality of the foot musculature (HP:0001436)1.75556405
138Primary atrial arrhythmia (HP:0001692)1.74876428
139Dilated cardiomyopathy (HP:0001644)1.74028577
140Abnormality of the hip-girdle musculature (HP:0001445)1.71293085
141Abnormality of the musculature of the pelvis (HP:0001469)1.71293085
142Round ear (HP:0100830)1.70717349
143Limb dystonia (HP:0002451)1.70315742
144Abnormality of binocular vision (HP:0011514)1.70276832
145Atrial fibrillation (HP:0005110)1.69837135
146Breech presentation (HP:0001623)1.67942701
147Steppage gait (HP:0003376)1.66878507
148Difficulty climbing stairs (HP:0003551)1.65910347
149Muscular dystrophy (HP:0003560)1.64132603
150Infantile muscular hypotonia (HP:0008947)1.62833378
151Abnormal atrioventricular conduction (HP:0005150)1.62692842
152Ulnar deviation of finger (HP:0009465)1.60892432
153Foot dorsiflexor weakness (HP:0009027)1.58705115
154Waddling gait (HP:0002515)1.56492868

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.54758124
2EPHA43.75384005
3MARK13.37871122
4MAP3K93.11146819
5MAP3K42.76310559
6CASK2.49250453
7MINK12.39731685
8MAP2K72.34461467
9PHKG22.13662202
10PHKG12.13662202
11KSR22.05248439
12DAPK22.02094184
13NTRK12.00410505
14MAP2K41.96488190
15PAK61.87201668
16PNCK1.84640670
17RIPK41.81270543
18KSR11.80772185
19NTRK21.72891457
20PLK21.72659795
21MAP3K121.69857318
22MAPK131.55296847
23OBSCN1.46792524
24MAP3K21.45112286
25PRKD31.40061219
26CDK51.37305113
27TNIK1.34900433
28GRK51.32510650
29PIK3CG1.26080585
30SIK21.22057952
31NME11.21573701
32CAMKK11.20626782
33PAK31.15673080
34DAPK11.12702547
35CAMK2A1.12267638
36UHMK11.11664982
37CAMKK21.09046913
38PRKCG1.05509087
39LATS21.00813894
40LIMK10.99157482
41INSRR0.98510524
42BMPR20.95784501
43ARAF0.95074084
44RET0.92432533
45CAMK2B0.89196088
46ERBB30.86659423
47PKN10.86252548
48PTK2B0.85853403
49DMPK0.84422944
50MAP3K130.83826600
51FER0.82188569
52WNK30.81561354
53STK380.80201077
54CAMK1G0.76321140
55PRKCE0.75938356
56SGK10.75667136
57RIPK10.75658440
58CAMK2D0.74968145
59PRPF4B0.74263535
60DYRK20.74246528
61MOS0.74187521
62PRKAA10.73379134
63SGK30.71298745
64CSNK1G20.71266384
65TTN0.70940982
66RAF10.69761711
67CAMK40.69595140
68CDK190.68797071
69CDK140.68648688
70PRKG10.68129096
71SGK4940.67195843
72SGK2230.67195843
73TIE10.66392589
74CDK180.65988490
75DDR20.65881109
76DYRK1A0.65758897
77MUSK0.65391005
78EPHA30.65378575
79MARK20.64716602
80CAMK10.64227657
81LMTK20.64216152
82PINK10.64056526
83MAP3K10.64047749
84ROCK10.63844307
85STK110.63699756
86CDK150.62196586
87CSNK1G10.60405586
88FES0.59268648
89PRKCH0.58694025
90SGK20.57326307
91LATS10.57156805
92FGR0.56194532
93MAP2K10.55021597
94MAP3K70.54629736
95TRPM70.53697651
96PDK30.53479306
97PDK40.53479306
98NEK90.52663689
99CDC42BPA0.51789814
100AKT30.51362618
101CDK11A0.51109087
102TYRO30.50788814
103MAPK120.49787658
104PRKAA20.49665629
105CSNK1A1L0.49577809
106DYRK1B0.49258809
107CSNK1G30.49092774
108BCR0.48536999
109FRK0.47641438
110CAMK2G0.45503938
111RPS6KA30.44847867
112PDGFRA0.44795382
113OXSR10.44401576
114CCNB10.44177234
115PRKACA0.43670406
116PTK20.42483209
117ROCK20.42412069
118EPHB20.41770620
119MAP3K60.41741172
120MAPK40.41455212
121WNK10.41056381
122RPS6KA20.41034632
123WNK40.40992458
124MAPK100.40873761
125PIK3CA0.40562112
126PDPK10.39983888
127GRK70.39907944
128EEF2K0.39675087
129PAK20.39501644
130ICK0.38173528
131MYLK0.37209329
132MAPK70.36566201

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.39331157
2Long-term potentiation_Homo sapiens_hsa047202.64661191
3Synaptic vesicle cycle_Homo sapiens_hsa047212.58765624
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.56463117
5Circadian entrainment_Homo sapiens_hsa047132.54296948
6Amphetamine addiction_Homo sapiens_hsa050312.36451086
7GABAergic synapse_Homo sapiens_hsa047272.35367528
8Glutamatergic synapse_Homo sapiens_hsa047242.30865107
9Olfactory transduction_Homo sapiens_hsa047402.28864671
10Insulin secretion_Homo sapiens_hsa049112.26454573
11Morphine addiction_Homo sapiens_hsa050322.21502618
12Dopaminergic synapse_Homo sapiens_hsa047282.11340146
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00787949
14Salivary secretion_Homo sapiens_hsa049701.95354582
15Taste transduction_Homo sapiens_hsa047421.92732188
16Renin secretion_Homo sapiens_hsa049241.90480261
17Cholinergic synapse_Homo sapiens_hsa047251.80637166
18* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.76723941
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76331906
20Gastric acid secretion_Homo sapiens_hsa049711.76288139
21* Oxytocin signaling pathway_Homo sapiens_hsa049211.75348984
22Serotonergic synapse_Homo sapiens_hsa047261.74602896
23Long-term depression_Homo sapiens_hsa047301.66216737
24Calcium signaling pathway_Homo sapiens_hsa040201.65764152
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52730306
26Cocaine addiction_Homo sapiens_hsa050301.52449073
27GnRH signaling pathway_Homo sapiens_hsa049121.46974735
28* Cardiac muscle contraction_Homo sapiens_hsa042601.46428929
29Gap junction_Homo sapiens_hsa045401.35661691
30Type II diabetes mellitus_Homo sapiens_hsa049301.33867230
31Collecting duct acid secretion_Homo sapiens_hsa049661.32278030
32Axon guidance_Homo sapiens_hsa043601.30817934
33cGMP-PKG signaling pathway_Homo sapiens_hsa040221.27166329
34* Dilated cardiomyopathy_Homo sapiens_hsa054141.25554553
35cAMP signaling pathway_Homo sapiens_hsa040241.24395170
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21547663
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17925624
38Estrogen signaling pathway_Homo sapiens_hsa049151.17361164
39Vascular smooth muscle contraction_Homo sapiens_hsa042701.12746999
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11332147
41Melanogenesis_Homo sapiens_hsa049161.08386631
42Glioma_Homo sapiens_hsa052141.08260558
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04800374
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03754908
45Vibrio cholerae infection_Homo sapiens_hsa051101.02593987
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02288169
47* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97262801
48* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.96833173
49Glucagon signaling pathway_Homo sapiens_hsa049220.96058639
50Focal adhesion_Homo sapiens_hsa045100.95426611
51ECM-receptor interaction_Homo sapiens_hsa045120.95162263
52ErbB signaling pathway_Homo sapiens_hsa040120.94352562
53Dorso-ventral axis formation_Homo sapiens_hsa043200.94078741
54Alzheimers disease_Homo sapiens_hsa050100.93348902
55Pancreatic secretion_Homo sapiens_hsa049720.92710105
56Circadian rhythm_Homo sapiens_hsa047100.87351709
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85470895
58Oocyte meiosis_Homo sapiens_hsa041140.82658522
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82037862
60Phototransduction_Homo sapiens_hsa047440.76109338
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75281206
62Thyroid hormone synthesis_Homo sapiens_hsa049180.72887238
63Oxidative phosphorylation_Homo sapiens_hsa001900.72511152
64* MAPK signaling pathway_Homo sapiens_hsa040100.72453965
65Hippo signaling pathway_Homo sapiens_hsa043900.72171921
66VEGF signaling pathway_Homo sapiens_hsa043700.71737489
67Adherens junction_Homo sapiens_hsa045200.71067217
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.70788008
69Insulin signaling pathway_Homo sapiens_hsa049100.69216151
70Choline metabolism in cancer_Homo sapiens_hsa052310.68603375
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64941450
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63823539
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.62898377
74Hedgehog signaling pathway_Homo sapiens_hsa043400.62293419
75Insulin resistance_Homo sapiens_hsa049310.61917925
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61796832
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61123266
78Arginine and proline metabolism_Homo sapiens_hsa003300.61097504
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60952995
80Ras signaling pathway_Homo sapiens_hsa040140.60703174
81Propanoate metabolism_Homo sapiens_hsa006400.60295035
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59604632
83Protein digestion and absorption_Homo sapiens_hsa049740.58612105
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54463127
85Parkinsons disease_Homo sapiens_hsa050120.54375220
86mTOR signaling pathway_Homo sapiens_hsa041500.54231001
87Basal cell carcinoma_Homo sapiens_hsa052170.54088564
88Renal cell carcinoma_Homo sapiens_hsa052110.54008034
89Wnt signaling pathway_Homo sapiens_hsa043100.52957036
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51988822
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51779978
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50640382
93Rap1 signaling pathway_Homo sapiens_hsa040150.49412024
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48846258
95Bile secretion_Homo sapiens_hsa049760.47722010
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.47269851
97Endometrial cancer_Homo sapiens_hsa052130.46643556
98Alcoholism_Homo sapiens_hsa050340.45673205
99FoxO signaling pathway_Homo sapiens_hsa040680.45013824
100Inositol phosphate metabolism_Homo sapiens_hsa005620.44498885
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43948879
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43865850
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.43605144
104Type I diabetes mellitus_Homo sapiens_hsa049400.42919002
105Ovarian steroidogenesis_Homo sapiens_hsa049130.42423148
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42301192
107Prion diseases_Homo sapiens_hsa050200.42296023
108Fatty acid metabolism_Homo sapiens_hsa012120.41771219
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41179668
110Pyruvate metabolism_Homo sapiens_hsa006200.38664845
111Amoebiasis_Homo sapiens_hsa051460.38064726
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37495456
113Huntingtons disease_Homo sapiens_hsa050160.37377530
114Butanoate metabolism_Homo sapiens_hsa006500.36807403
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35597557
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34082258
117Tight junction_Homo sapiens_hsa045300.32535607
118Prolactin signaling pathway_Homo sapiens_hsa049170.31888311
119AMPK signaling pathway_Homo sapiens_hsa041520.31641657
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.30263750
121Endocytosis_Homo sapiens_hsa041440.30245568
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28849887
123Non-small cell lung cancer_Homo sapiens_hsa052230.27941720

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