CACNA2D2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1surfactant homeostasis (GO:0043129)7.36108076
2chemical homeostasis within a tissue (GO:0048875)6.30711147
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.79618383
4vocalization behavior (GO:0071625)5.54332546
5locomotory exploration behavior (GO:0035641)5.53296366
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.47434069
7synaptic vesicle maturation (GO:0016188)5.34807231
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.17653216
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.98130382
10synaptic vesicle exocytosis (GO:0016079)4.79323853
11ionotropic glutamate receptor signaling pathway (GO:0035235)4.75440110
12gamma-aminobutyric acid transport (GO:0015812)4.74820241
13neurotransmitter secretion (GO:0007269)4.63073763
14neuron cell-cell adhesion (GO:0007158)4.63073105
15regulation of glutamate receptor signaling pathway (GO:1900449)4.58516088
16regulation of synaptic vesicle exocytosis (GO:2000300)4.58039215
17layer formation in cerebral cortex (GO:0021819)4.41424611
18dendritic spine morphogenesis (GO:0060997)4.36978530
19neuronal action potential propagation (GO:0019227)4.36099119
20protein localization to synapse (GO:0035418)4.30400522
21glutamate receptor signaling pathway (GO:0007215)4.24173230
22glutamate secretion (GO:0014047)4.22908786
23cerebellar Purkinje cell differentiation (GO:0021702)4.20696165
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.19877774
25exploration behavior (GO:0035640)4.16442234
26synaptic transmission, glutamatergic (GO:0035249)4.09205644
27sodium ion export (GO:0071436)4.07351485
28cellular potassium ion homeostasis (GO:0030007)4.07156188
29regulation of synaptic vesicle transport (GO:1902803)4.01321866
30regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.00083542
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.99035454
32regulation of synapse structural plasticity (GO:0051823)3.98360987
33prepulse inhibition (GO:0060134)3.96456910
34neuron-neuron synaptic transmission (GO:0007270)3.93101833
35auditory behavior (GO:0031223)3.89031874
36neurotransmitter transport (GO:0006836)3.88119205
37negative regulation of protein oligomerization (GO:0032460)3.86501253
38synaptic vesicle docking involved in exocytosis (GO:0016081)3.84464839
39transmission of nerve impulse (GO:0019226)3.83663196
40regulation of neuronal synaptic plasticity (GO:0048168)3.81760795
41long-term memory (GO:0007616)3.78266712
42proline transport (GO:0015824)3.77120486
43neuromuscular process controlling posture (GO:0050884)3.75768962
44cellular response to nitric oxide (GO:0071732)3.75332682
45positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.74931549
46positive regulation of synaptic transmission, GABAergic (GO:0032230)3.72130576
47cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.70175084
48glycine transport (GO:0015816)3.69645348
49response to pheromone (GO:0019236)3.68953293
50neuron recognition (GO:0008038)3.61311236
51positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.61102678
52regulation of neurotransmitter levels (GO:0001505)3.61066957
53regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.58376604
54response to auditory stimulus (GO:0010996)3.57080413
55G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.53834761
56cell communication by electrical coupling (GO:0010644)3.53284868
57protein import into peroxisome matrix (GO:0016558)3.51899660
58membrane depolarization during action potential (GO:0086010)3.51575675
59regulation of excitatory postsynaptic membrane potential (GO:0060079)3.51481815
60membrane hyperpolarization (GO:0060081)3.50767597
61positive regulation of membrane potential (GO:0045838)3.49281028
62neurotransmitter-gated ion channel clustering (GO:0072578)3.49132857
63neuromuscular process controlling balance (GO:0050885)3.47728395
64presynaptic membrane assembly (GO:0097105)3.46217961
65gamma-aminobutyric acid signaling pathway (GO:0007214)3.45986250
66activation of protein kinase A activity (GO:0034199)3.45209968
67neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.44863878
68presynaptic membrane organization (GO:0097090)3.43243707
69regulation of postsynaptic membrane potential (GO:0060078)3.41255737
70histone H4-K12 acetylation (GO:0043983)3.40777763
71regulation of gene silencing by RNA (GO:0060966)3.39825997
72regulation of posttranscriptional gene silencing (GO:0060147)3.39825997
73regulation of gene silencing by miRNA (GO:0060964)3.39825997
74mating behavior (GO:0007617)3.39692019
75peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.37838170
76respiratory gaseous exchange (GO:0007585)3.37148268
77positive regulation of potassium ion transmembrane transport (GO:1901381)3.31358360
78axonal fasciculation (GO:0007413)3.29825756
79regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.29584449
80cerebellar granule cell differentiation (GO:0021707)3.28764345
81negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.26166153
82dendrite morphogenesis (GO:0048813)3.25670028
83regulation of synaptic transmission, glutamatergic (GO:0051966)3.24770279
84innervation (GO:0060384)3.22386050
85negative regulation of cytosolic calcium ion concentration (GO:0051481)3.20862178
86regulation of vesicle fusion (GO:0031338)3.20857709
87membrane depolarization (GO:0051899)3.20786477
88neuronal ion channel clustering (GO:0045161)3.20335666
89regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.19293327
90response to histamine (GO:0034776)3.18977373
91postsynaptic membrane organization (GO:0001941)3.18741437
92synaptic vesicle endocytosis (GO:0048488)3.17314776
93synapse assembly (GO:0007416)3.16182584
94positive regulation of synapse maturation (GO:0090129)3.16090540
95regulation of neurotransmitter secretion (GO:0046928)3.13290341
96regulation of dendritic spine morphogenesis (GO:0061001)3.13146812
97negative regulation of synaptic transmission, GABAergic (GO:0032229)3.12715934
98establishment of nucleus localization (GO:0040023)3.12421929
99positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.11365442
100pyrimidine nucleobase catabolic process (GO:0006208)3.11165837
101adult walking behavior (GO:0007628)3.11155697
102cell differentiation in hindbrain (GO:0021533)3.09017918
103potassium ion homeostasis (GO:0055075)3.08211889
104mechanosensory behavior (GO:0007638)3.06647707
105positive regulation of synapse assembly (GO:0051965)3.05766919
106intraspecies interaction between organisms (GO:0051703)3.01962478
107social behavior (GO:0035176)3.01962478
108regulation of synaptic transmission, GABAergic (GO:0032228)3.00256548
109regulation of neurotransmitter transport (GO:0051588)2.98990360
110regulation of respiratory gaseous exchange (GO:0043576)2.97405629
111potassium ion import (GO:0010107)2.96670715
112behavioral response to cocaine (GO:0048148)2.95703560
113striatum development (GO:0021756)2.94481798
114learning (GO:0007612)2.92816188
115dopamine receptor signaling pathway (GO:0007212)2.92714001
116cell migration in hindbrain (GO:0021535)2.92431182
117cellular sodium ion homeostasis (GO:0006883)2.92274763
118regulation of synaptic plasticity (GO:0048167)2.91236583
119neuromuscular process (GO:0050905)2.89801736
120establishment of mitochondrion localization (GO:0051654)2.87924008
121establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.86655652
122mitochondrion transport along microtubule (GO:0047497)2.86655652
123chemosensory behavior (GO:0007635)2.83336991
124collecting duct development (GO:0072044)2.69980313
125adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.67646980
126cochlea development (GO:0090102)2.66132115
127cerebellar Purkinje cell layer development (GO:0021680)2.64564798
128short-term memory (GO:0007614)2.63839295
129camera-type eye morphogenesis (GO:0048593)2.60688647
130neuron maturation (GO:0042551)2.51283270
131apical protein localization (GO:0045176)2.49587437
132* synapse organization (GO:0050808)2.49405229
133lung-associated mesenchyme development (GO:0060484)2.48472586
134nucleobase catabolic process (GO:0046113)2.45927430
135neuron remodeling (GO:0016322)2.45733563
136cell-cell junction maintenance (GO:0045217)2.45270782
137dendritic spine organization (GO:0097061)2.45134678
138organelle transport along microtubule (GO:0072384)2.44604121
139cellular response to reactive nitrogen species (GO:1902170)2.44470390
140nodal signaling pathway (GO:0038092)2.41790298
141regulation of respiratory system process (GO:0044065)2.41585743

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.00619067
2GBX2_23144817_ChIP-Seq_PC3_Human3.17599501
3* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12609621
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10551073
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10188153
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.81366634
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.81366634
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.76523588
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.71422014
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.66043784
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.58233618
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56619914
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55700001
14DROSHA_22980978_ChIP-Seq_HELA_Human2.53407611
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53023686
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49113776
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.45981970
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.43115240
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.40374016
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.38727422
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.35814180
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32583785
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25583660
24* REST_18959480_ChIP-ChIP_MESCs_Mouse2.24028463
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.22812300
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.20100776
27STAT6_21828071_ChIP-Seq_BEAS2B_Human2.12867979
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03564055
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.95318347
30* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93180274
31SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.88017035
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.79826976
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79250678
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76868910
35AR_21572438_ChIP-Seq_LNCaP_Human1.76169751
36TAF15_26573619_Chip-Seq_HEK293_Human1.64226327
37ZNF274_21170338_ChIP-Seq_K562_Hela1.60424550
38SMAD4_21799915_ChIP-Seq_A2780_Human1.57092864
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52933010
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47786215
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45579523
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44844095
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42315481
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.42240235
45RING1B_27294783_Chip-Seq_ESCs_Mouse1.38806362
46ZFP281_27345836_Chip-Seq_ESCs_Mouse1.36112179
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.35585051
48* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30638545
49SOX2_21211035_ChIP-Seq_LN229_Gbm1.29863069
50RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29285746
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28368578
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27148137
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26436459
54AR_19668381_ChIP-Seq_PC3_Human1.24868044
55ISL1_27105846_Chip-Seq_CPCs_Mouse1.24563202
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.24356995
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24207009
58DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24140286
59P300_19829295_ChIP-Seq_ESCs_Human1.23923162
60TP53_20018659_ChIP-ChIP_R1E_Mouse1.21452571
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20200103
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18461146
63* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18325580
64RNF2_27304074_Chip-Seq_NSC_Mouse1.17696161
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.17007384
66KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.14827011
67KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.14827011
68KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.14827011
69* STAT3_23295773_ChIP-Seq_U87_Human1.13926195
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13316855
71AR_25329375_ChIP-Seq_VCAP_Human1.13156038
72STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11397988
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10199713
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10179466
75* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10074466
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09105481
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.08970024
78KDM2B_26808549_Chip-Seq_K562_Human1.08724212
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.08691651
80* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07792713
81* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07393678
82KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04851553
83P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03602243
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02774612
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02769989
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02595932
87* TCF4_23295773_ChIP-Seq_U87_Human1.01753756
88IGF1R_20145208_ChIP-Seq_DFB_Human1.01265463
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99242705
90* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99207285
91YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98279006
92GATA1_26923725_Chip-Seq_HPCs_Mouse0.98213053
93* RUNX2_22187159_ChIP-Seq_PCA_Human0.98194882
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96905681
95SMAD3_21741376_ChIP-Seq_ESCs_Human0.96787446
96ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96606312
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96320446
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96186089
99DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95760603
100* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95324906
101PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.95298992
102LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93872123
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93375331
104NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.93168165
105WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92693284
106SMAD4_21741376_ChIP-Seq_HESCs_Human0.92357018
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91302281
108ARNT_22903824_ChIP-Seq_MCF-7_Human0.90013967
109AHR_22903824_ChIP-Seq_MCF-7_Human0.89630447
110NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.89587076
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88118860
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88118860
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87973577
114POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.87304166
115RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87068599
116TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.87003309
117EP300_21415370_ChIP-Seq_HL-1_Mouse0.85764340
118* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85412338
119* CTCF_27219007_Chip-Seq_Bcells_Human0.84745335
120POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84196722
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84054323
122ER_23166858_ChIP-Seq_MCF-7_Human0.83626411
123STAT3_18555785_ChIP-Seq_MESCs_Mouse0.83542270
124OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83024192
125BCAT_22108803_ChIP-Seq_LS180_Human0.82782220
126SMAD3_21741376_ChIP-Seq_HESCs_Human0.82179473
127TET1_21490601_ChIP-Seq_MESCs_Mouse0.81013709
128CREB1_26743006_Chip-Seq_LNCaP_Human0.76603912
129OCT4_19829295_ChIP-Seq_ESCs_Human0.75118279

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.37026895
2MP0003880_abnormal_central_pattern4.37979884
3MP0004782_abnormal_surfactant_physiolog3.96844957
4* MP0003635_abnormal_synaptic_transmissio3.93052966
5MP0005423_abnormal_somatic_nervous3.48585059
6* MP0009046_muscle_twitch3.46045879
7MP0002254_reproductive_system_inflammat3.44866390
8* MP0009745_abnormal_behavioral_response3.33412732
9MP0004270_analgesia3.07657224
10* MP0002064_seizures3.07052534
11MP0002063_abnormal_learning/memory/cond3.03800240
12MP0002822_catalepsy2.98443975
13MP0001968_abnormal_touch/_nociception2.92783598
14MP0002572_abnormal_emotion/affect_behav2.72001007
15MP0000566_synostosis2.66332831
16MP0001486_abnormal_startle_reflex2.65809345
17* MP0002272_abnormal_nervous_system2.63228513
18MP0002734_abnormal_mechanical_nocicepti2.58338486
19MP0008995_early_reproductive_senescence2.27310507
20MP0001501_abnormal_sleep_pattern2.19516924
21MP0003122_maternal_imprinting2.18338194
22MP0001440_abnormal_grooming_behavior2.14599019
23MP0006276_abnormal_autonomic_nervous2.13657408
24MP0002736_abnormal_nociception_after2.13028765
25MP0008569_lethality_at_weaning2.07778109
26MP0002733_abnormal_thermal_nociception2.07057139
27* MP0002067_abnormal_sensory_capabilities2.06215639
28MP0002735_abnormal_chemical_nociception2.02906650
29MP0001958_emphysema2.01159201
30MP0002184_abnormal_innervation1.98165900
31MP0001970_abnormal_pain_threshold1.96798198
32MP0005386_behavior/neurological_phenoty1.90561858
33MP0004924_abnormal_behavior1.90561858
34MP0005646_abnormal_pituitary_gland1.87432374
35MP0008877_abnormal_DNA_methylation1.85990382
36MP0001529_abnormal_vocalization1.83408208
37MP0000778_abnormal_nervous_system1.83365667
38MP0004133_heterotaxia1.82254608
39* MP0002557_abnormal_social/conspecific_i1.80323192
40MP0002909_abnormal_adrenal_gland1.75642726
41MP0004142_abnormal_muscle_tone1.66213087
42MP0001984_abnormal_olfaction1.64641998
43MP0001346_abnormal_lacrimal_gland1.63156866
44MP0005645_abnormal_hypothalamus_physiol1.59443731
45* MP0004811_abnormal_neuron_physiology1.58779656
46MP0004885_abnormal_endolymph1.51001418
47MP0003329_amyloid_beta_deposits1.49000135
48MP0004858_abnormal_nervous_system1.48211603
49* MP0000955_abnormal_spinal_cord1.44563884
50* MP0002882_abnormal_neuron_morphology1.44516475
51* MP0002066_abnormal_motor_capabilities/c1.44261540
52MP0003890_abnormal_embryonic-extraembry1.43135735
53MP0004145_abnormal_muscle_electrophysio1.40607990
54MP0008004_abnormal_stomach_pH1.40455808
55MP0003136_yellow_coat_color1.35815924
56MP0001348_abnormal_lacrimal_gland1.35432255
57MP0001502_abnormal_circadian_rhythm1.34243570
58MP0001905_abnormal_dopamine_level1.33841222
59MP0009780_abnormal_chondrocyte_physiolo1.31982303
60MP0005551_abnormal_eye_electrophysiolog1.28358738
61MP0003787_abnormal_imprinting1.28078095
62MP0000751_myopathy1.25816410
63MP0001188_hyperpigmentation1.25808954
64MP0002638_abnormal_pupillary_reflex1.18543021
65MP0004742_abnormal_vestibular_system1.15937781
66* MP0002152_abnormal_brain_morphology1.15703001
67MP0003633_abnormal_nervous_system1.15555940
68MP0006082_CNS_inflammation1.15039063
69MP0003879_abnormal_hair_cell1.14931061
70MP0008872_abnormal_physiological_respon1.13802750
71MP0003137_abnormal_impulse_conducting1.13777412
72MP0003119_abnormal_digestive_system1.13256773
73MP0005388_respiratory_system_phenotype1.12515900
74MP0002133_abnormal_respiratory_system1.12515900
75MP0003878_abnormal_ear_physiology1.11409394
76MP0005377_hearing/vestibular/ear_phenot1.11409394
77MP0006072_abnormal_retinal_apoptosis1.07390106
78MP0001986_abnormal_taste_sensitivity1.07091916
79* MP0002229_neurodegeneration1.06966291
80MP0005394_taste/olfaction_phenotype1.05022915
81MP0005499_abnormal_olfactory_system1.05022915
82* MP0004085_abnormal_heartbeat1.03737153
83MP0000569_abnormal_digit_pigmentation1.02781868
84MP0004215_abnormal_myocardial_fiber1.02575659
85MP0003631_nervous_system_phenotype1.02032544
86MP0003938_abnormal_ear_development1.01696369
87MP0003283_abnormal_digestive_organ1.01674444
88MP0010030_abnormal_orbit_morphology1.01056449
89MP0003121_genomic_imprinting0.91699742
90MP0001944_abnormal_pancreas_morphology0.89083153
91MP0005409_darkened_coat_color0.88971616
92MP0003632_abnormal_nervous_system0.86409466
93* MP0002752_abnormal_somatic_nervous0.86408084
94* MP0002069_abnormal_eating/drinking_beha0.85437248
95MP0003115_abnormal_respiratory_system0.82947048
96MP0000013_abnormal_adipose_tissue0.82847386
97* MP0003634_abnormal_glial_cell0.82613515
98MP0001177_atelectasis0.81415423
99MP0001963_abnormal_hearing_physiology0.78872785
100MP0000534_abnormal_ureter_morphology0.77250099
101MP0002653_abnormal_ependyma_morphology0.77225617
102MP0001485_abnormal_pinna_reflex0.77166273
103MP0008874_decreased_physiological_sensi0.76075901
104MP0005253_abnormal_eye_physiology0.75555417
105* MP0000631_abnormal_neuroendocrine_gland0.74893660
106MP0003123_paternal_imprinting0.74864305
107MP0005448_abnormal_energy_balance0.74514224
108MP0000537_abnormal_urethra_morphology0.74237274
109MP0000462_abnormal_digestive_system0.73168302
110MP0005535_abnormal_body_temperature0.72643827
111MP0002295_abnormal_pulmonary_circulatio0.72260799
112MP0001299_abnormal_eye_distance/0.71644780
113MP0000026_abnormal_inner_ear0.71564916
114MP0004233_abnormal_muscle_weight0.70796881
115MP0005595_abnormal_vascular_smooth0.70641218
116MP0008961_abnormal_basal_metabolism0.69903740
117MP0005623_abnormal_meninges_morphology0.68536186
118MP0002837_dystrophic_cardiac_calcinosis0.68164879
119MP0003942_abnormal_urinary_system0.67576368
120MP0010386_abnormal_urinary_bladder0.65704506
121* MP0000920_abnormal_myelination0.64878104
122MP0002090_abnormal_vision0.64465362
123MP0001943_abnormal_respiration0.64240920
124* MP0003690_abnormal_glial_cell0.62758388
125* MP0003861_abnormal_nervous_system0.62410577
126* MP0010769_abnormal_survival0.58863574
127* MP0010770_preweaning_lethality0.58160952
128* MP0002082_postnatal_lethality0.58160952
129MP0004484_altered_response_of0.57486283
130MP0006292_abnormal_olfactory_placode0.56371422
131* MP0010768_mortality/aging0.55499966
132MP0001664_abnormal_digestion0.53830902

Predicted human phenotypes

RankGene SetZ-score
1Interstitial pulmonary disease (HP:0006530)6.97195921
2Focal motor seizures (HP:0011153)6.66886878
3Myokymia (HP:0002411)6.26376176
4Focal seizures (HP:0007359)5.56297141
5Visual hallucinations (HP:0002367)5.28363802
6Progressive cerebellar ataxia (HP:0002073)4.72769329
7Action tremor (HP:0002345)4.51380814
8Atonic seizures (HP:0010819)4.18272190
9Febrile seizures (HP:0002373)4.16058136
10Absence seizures (HP:0002121)3.89678218
11Epileptic encephalopathy (HP:0200134)3.80586331
12Generalized tonic-clonic seizures (HP:0002069)3.76633962
13Tachypnea (HP:0002789)3.74245253
14Broad-based gait (HP:0002136)3.53664743
15Dialeptic seizures (HP:0011146)3.44666665
16Supranuclear gaze palsy (HP:0000605)3.36145308
17Ankle clonus (HP:0011448)3.34933871
18Dysdiadochokinesis (HP:0002075)3.34061976
19Gaze-evoked nystagmus (HP:0000640)3.32097431
20Limb dystonia (HP:0002451)3.28772215
21Mutism (HP:0002300)3.27900629
22Respiratory distress (HP:0002098)3.27206777
23Anxiety (HP:0000739)3.20500300
24Truncal ataxia (HP:0002078)3.15739947
25Depression (HP:0000716)3.12851763
26Hemiparesis (HP:0001269)3.11767631
27Abnormality of calcium-phosphate metabolism (HP:0100530)3.11412172
28Poor eye contact (HP:0000817)3.11176456
29Bronchomalacia (HP:0002780)3.09931880
30Hepatoblastoma (HP:0002884)3.03124994
31Abnormality of the fingertips (HP:0001211)3.01491271
32Dysmetria (HP:0001310)2.94150079
33Impaired vibration sensation in the lower limbs (HP:0002166)2.90417647
34Progressive inability to walk (HP:0002505)2.90114845
35Abnormal eating behavior (HP:0100738)2.88552768
36Abnormal social behavior (HP:0012433)2.88064836
37Impaired social interactions (HP:0000735)2.88064836
38Hemiplegia (HP:0002301)2.86920574
39Ventricular fibrillation (HP:0001663)2.85817363
40Scanning speech (HP:0002168)2.84791112
41Genetic anticipation (HP:0003743)2.82253180
42Urinary bladder sphincter dysfunction (HP:0002839)2.80206492
43Abnormality of binocular vision (HP:0011514)2.79585011
44Diplopia (HP:0000651)2.79585011
45Postural instability (HP:0002172)2.77642050
46Hypercortisolism (HP:0001578)2.72312328
47Impaired smooth pursuit (HP:0007772)2.69325718
48Sleep apnea (HP:0010535)2.69298641
49Tubulointerstitial fibrosis (HP:0005576)2.68733890
50Obstructive sleep apnea (HP:0002870)2.68732371
51Agitation (HP:0000713)2.67122243
52Pheochromocytoma (HP:0002666)2.66881692
53Septo-optic dysplasia (HP:0100842)2.64214758
54Turricephaly (HP:0000262)2.63073763
55Intention tremor (HP:0002080)2.60489068
56Prolonged QT interval (HP:0001657)2.56430957
57Drooling (HP:0002307)2.56165484
58Excessive salivation (HP:0003781)2.56165484
59Spastic gait (HP:0002064)2.49327685
60Dysmetric saccades (HP:0000641)2.47874285
61Torticollis (HP:0000473)2.47852758
62Abnormality of ocular smooth pursuit (HP:0000617)2.47088202
63Papilledema (HP:0001085)2.46391438
64Urinary urgency (HP:0000012)2.44838382
65Abnormal EKG (HP:0003115)2.42089622
66Abnormality of the corticospinal tract (HP:0002492)2.39410129
67Abnormality of the lower motor neuron (HP:0002366)2.33748769
68Focal dystonia (HP:0004373)2.29751495
69Amblyopia (HP:0000646)2.28873626
70Status epilepticus (HP:0002133)2.28352162
71Neuroendocrine neoplasm (HP:0100634)2.28132736
72Bradykinesia (HP:0002067)2.25113551
73Postural tremor (HP:0002174)2.23777229
74Brushfield spots (HP:0001088)2.22330166
75Asplenia (HP:0001746)2.21904490
76Amyotrophic lateral sclerosis (HP:0007354)2.21728648
77Cutaneous finger syndactyly (HP:0010554)2.21506028
78Abnormality of the labia minora (HP:0012880)2.20933623
79Abdominal situs inversus (HP:0003363)2.20260019
80Abnormality of abdominal situs (HP:0011620)2.20260019
81Polyphagia (HP:0002591)2.19152001
82Megalencephaly (HP:0001355)2.18734131
83Thickened helices (HP:0000391)2.17219893
84Lower limb muscle weakness (HP:0007340)2.17193342
85Tetraplegia (HP:0002445)2.17192020
86Partial duplication of thumb phalanx (HP:0009944)2.14321446
87Aqueductal stenosis (HP:0002410)2.13750490
88Aplasia/Hypoplasia of the spleen (HP:0010451)2.12671536
89Stereotypic behavior (HP:0000733)2.12031873
90Shawl scrotum (HP:0000049)2.08383959
91Craniofacial dystonia (HP:0012179)2.07566904
92Psychosis (HP:0000709)2.07413602
93Cutaneous syndactyly (HP:0012725)2.06741712
94Neuronal loss in central nervous system (HP:0002529)2.06719488
95Neurofibrillary tangles (HP:0002185)2.05820058
96Insomnia (HP:0100785)2.03467952
97Osteomalacia (HP:0002749)2.00813475
98Failure to thrive in infancy (HP:0001531)1.99638656
99Incomplete penetrance (HP:0003829)1.99472504
100Midline defect of the nose (HP:0004122)1.99391053
101Termporal pattern (HP:0011008)1.98699472
102Insidious onset (HP:0003587)1.98699472
103Abnormality of saccadic eye movements (HP:0000570)1.97960498
104Syncope (HP:0001279)1.97470149
105Pointed chin (HP:0000307)1.96618104
106Adrenal overactivity (HP:0002717)1.95160479
107Fetal akinesia sequence (HP:0001989)1.94247679
108Restlessness (HP:0000711)1.93712658
109Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.92363579
110Specific learning disability (HP:0001328)1.91808902
111Optic nerve hypoplasia (HP:0000609)1.91312254
112EEG with generalized epileptiform discharges (HP:0011198)1.89673700
113Clonus (HP:0002169)1.89384864
114Enlarged penis (HP:0000040)1.88405914
115Annular pancreas (HP:0001734)1.87091725
116Epileptiform EEG discharges (HP:0011182)1.86539416
117Hyperventilation (HP:0002883)1.85541628
118Cerebral inclusion bodies (HP:0100314)1.85375322
119Abnormality of the aortic arch (HP:0012303)1.85374664
120Morphological abnormality of the pyramidal tract (HP:0002062)1.85339869
121Hypsarrhythmia (HP:0002521)1.83215183
122Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.82278160
123Short 4th metacarpal (HP:0010044)1.82278160
124High anterior hairline (HP:0009890)1.81655667
125Gait ataxia (HP:0002066)1.81237057
126Sudden death (HP:0001699)1.81196623
127Hypoventilation (HP:0002791)1.80637966
128Lower limb amyotrophy (HP:0007210)1.79038893
129Maternal diabetes (HP:0009800)1.78943022
130Growth hormone excess (HP:0000845)1.77922201
131Flat occiput (HP:0005469)1.77650114
132Horizontal nystagmus (HP:0000666)1.77468882
133Neoplasm of the heart (HP:0100544)1.76366887
134Impaired vibratory sensation (HP:0002495)1.75442045
135Aplasia involving bones of the extremities (HP:0009825)1.75321481
136Aplasia involving bones of the upper limbs (HP:0009823)1.75321481
137Aplasia of the phalanges of the hand (HP:0009802)1.75321481
138Central scotoma (HP:0000603)1.75195058
139Tracheomalacia (HP:0002779)1.74985138
140Partial duplication of the phalanx of hand (HP:0009999)1.73948404
141Sporadic (HP:0003745)1.73475177
142Coronal craniosynostosis (HP:0004440)1.73107644
143Trigonocephaly (HP:0000243)1.70522135
144Choanal stenosis (HP:0000452)1.69971750
145Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69955514
146Broad metatarsal (HP:0001783)1.68585725
147Alveolar cell carcinoma (HP:0006519)1.67384616
148Bicornuate uterus (HP:0000813)1.66322236
149Preaxial foot polydactyly (HP:0001841)1.65603184
150Neoplasm of the tracheobronchial system (HP:0100552)1.65255952
151Hypoglycemic seizures (HP:0002173)1.64421497
152Abnormality of the dental pulp (HP:0006479)1.62896655
153Absent septum pellucidum (HP:0001331)1.61310209
154Mixed hearing impairment (HP:0000410)1.59660288
155Intestinal atresia (HP:0011100)1.59383789
156Taurodontia (HP:0000679)1.59067936

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.33167730
2PASK3.85458528
3MAP3K93.69155055
4MARK13.67173771
5MAP3K43.16806705
6EPHA43.07546171
7NTRK22.93331134
8MINK12.74498042
9FGFR22.56651548
10MAP2K72.49546951
11PAK62.19588797
12MAP2K42.00533969
13PNCK1.96323191
14TNIK1.92949677
15MAP3K121.85041327
16NTRK11.83215253
17CAMKK11.70142633
18MAPK131.69439713
19DAPK21.68256171
20DYRK21.66060135
21SIK21.58070667
22CDK51.53113044
23UHMK11.51428627
24PHKG21.49962405
25PHKG11.49962405
26STK381.45612120
27PRKD31.44426162
28KSR21.39564674
29CASK1.39147969
30MAP3K71.32228063
31GRK51.30186819
32CAMKK21.26784531
33RIPK41.23483970
34FES1.21066033
35PRKCG1.20108593
36WNK11.17864524
37TYRO31.15588915
38KSR11.14493852
39CDC42BPA1.07547584
40SGK2231.04473540
41SGK4941.04473540
42LATS21.03849825
43EEF2K0.99515651
44STK110.99335653
45CAMK2A0.98469116
46LMTK20.98047157
47CDK190.97177366
48FGFR40.93541449
49PRKCH0.93462707
50MAPK150.92636601
51CDK150.92518989
52PRPF4B0.92265605
53CDK180.91861637
54PLK20.90935580
55CDK140.90588969
56CAMK10.90558226
57RIPK10.90493553
58TNK20.90488906
59ALK0.90228811
60RET0.86415316
61CAMK1G0.86233407
62SGK20.85492512
63PAK30.85105172
64MAPK120.82498563
65OBSCN0.81656525
66CSNK1G20.81281813
67ARAF0.81229834
68FGFR10.80273153
69DYRK1A0.80272135
70DAPK10.80268617
71CDK11A0.80078157
72CAMK1D0.79140235
73NLK0.74049086
74PINK10.73505808
75CAMK2B0.73324737
76MARK20.73216004
77ITK0.73068542
78SGK30.72866079
79MAP3K130.71219229
80SGK10.70555930
81TAOK10.69225581
82TIE10.68678766
83HIPK20.67835125
84EPHB20.67327955
85LIMK10.64210848
86MAP3K20.64038449
87TRIB30.62166009
88CDK30.61883763
89CAMK2D0.61460014
90CDK120.60403884
91RPS6KA30.59978333
92EPHA30.59871942
93OXSR10.59369228
94CAMK2G0.57526964
95PRKCZ0.55383873
96FGFR30.54845386
97NEK60.54199123
98FYN0.53297089
99RPS6KC10.52290213
100RPS6KL10.52290213
101RPS6KA60.51783000
102ROCK20.51717181
103FGR0.51456331
104CAMK40.50484145
105PRKCE0.49819414
106MAPK70.49298984
107MAPK100.48547498
108WNK30.48325152
109ADRBK10.47576755
110DYRK1B0.47431846
111ROCK10.46431110
112PKN10.46235693
113GRK70.45833022
114PRKG10.45827659
115ERBB30.45139944
116BCR0.44945380
117EPHB10.42507883
118PRKACA0.42182707
119PRKCB0.42099219
120RPS6KA20.41958047
121BMX0.40191928
122NEK10.40173260
123MAPKAPK50.39998170
124CSNK1G30.39489085
125PDK10.39156774
126GSK3B0.39072866
127MAP3K100.39056185
128INSRR0.38264935
129ERBB20.38159547
130MAP3K60.37554670
131PDPK10.37492663
132PRKDC0.36933573
133ICK0.36494597
134CSNK1D0.36474430
135CSNK1E0.36168905

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.11774522
2Synaptic vesicle cycle_Homo sapiens_hsa047213.11027859
3GABAergic synapse_Homo sapiens_hsa047272.98683142
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.72773529
5Olfactory transduction_Homo sapiens_hsa047402.69439419
6Circadian entrainment_Homo sapiens_hsa047132.65044322
7Glutamatergic synapse_Homo sapiens_hsa047242.62293824
8Morphine addiction_Homo sapiens_hsa050322.59970707
9Long-term potentiation_Homo sapiens_hsa047202.43246091
10Amphetamine addiction_Homo sapiens_hsa050312.27563870
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.20700817
12Dopaminergic synapse_Homo sapiens_hsa047282.14567665
13Salivary secretion_Homo sapiens_hsa049702.05967574
14Taste transduction_Homo sapiens_hsa047422.01278013
15Insulin secretion_Homo sapiens_hsa049111.94901181
16Cocaine addiction_Homo sapiens_hsa050301.94270523
17Long-term depression_Homo sapiens_hsa047301.87960139
18Gastric acid secretion_Homo sapiens_hsa049711.87444512
19Cholinergic synapse_Homo sapiens_hsa047251.87115838
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.82910830
21* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.75323783
22Serotonergic synapse_Homo sapiens_hsa047261.74917197
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71126623
24* Cardiac muscle contraction_Homo sapiens_hsa042601.68957330
25Renin secretion_Homo sapiens_hsa049241.60036724
26Basal cell carcinoma_Homo sapiens_hsa052171.59999187
27Calcium signaling pathway_Homo sapiens_hsa040201.56621478
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50988529
29* Oxytocin signaling pathway_Homo sapiens_hsa049211.48478748
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.46621965
31Phototransduction_Homo sapiens_hsa047441.45306829
32Tight junction_Homo sapiens_hsa045301.41448323
33Gap junction_Homo sapiens_hsa045401.37667585
34GnRH signaling pathway_Homo sapiens_hsa049121.35158335
35Type II diabetes mellitus_Homo sapiens_hsa049301.25851769
36Notch signaling pathway_Homo sapiens_hsa043301.24928421
37cAMP signaling pathway_Homo sapiens_hsa040241.23304401
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23227562
39Hippo signaling pathway_Homo sapiens_hsa043901.21090161
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20483676
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16510786
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16238154
43Estrogen signaling pathway_Homo sapiens_hsa049151.13298195
44Axon guidance_Homo sapiens_hsa043601.12339141
45Collecting duct acid secretion_Homo sapiens_hsa049661.12165085
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02995936
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99457437
48* Dilated cardiomyopathy_Homo sapiens_hsa054140.97119702
49Melanogenesis_Homo sapiens_hsa049160.96390320
50Pancreatic secretion_Homo sapiens_hsa049720.92329538
51ErbB signaling pathway_Homo sapiens_hsa040120.91590302
52Mineral absorption_Homo sapiens_hsa049780.88267776
53Ether lipid metabolism_Homo sapiens_hsa005650.87018023
54Nitrogen metabolism_Homo sapiens_hsa009100.86869150
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.86676854
56Parkinsons disease_Homo sapiens_hsa050120.86301565
57Alzheimers disease_Homo sapiens_hsa050100.85449091
58Thyroid hormone synthesis_Homo sapiens_hsa049180.85133525
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82422975
60Glioma_Homo sapiens_hsa052140.81391512
61Dorso-ventral axis formation_Homo sapiens_hsa043200.80871675
62Oocyte meiosis_Homo sapiens_hsa041140.79953055
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.79801599
64Oxidative phosphorylation_Homo sapiens_hsa001900.79226844
65Adherens junction_Homo sapiens_hsa045200.79179920
66Folate biosynthesis_Homo sapiens_hsa007900.78059581
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77887656
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68407655
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67235848
70Vibrio cholerae infection_Homo sapiens_hsa051100.64818629
71* MAPK signaling pathway_Homo sapiens_hsa040100.62725761
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62594140
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61556710
74Selenocompound metabolism_Homo sapiens_hsa004500.60727350
75ABC transporters_Homo sapiens_hsa020100.59163977
76Choline metabolism in cancer_Homo sapiens_hsa052310.59102551
77Protein digestion and absorption_Homo sapiens_hsa049740.59061053
78Bile secretion_Homo sapiens_hsa049760.58011182
79Alcoholism_Homo sapiens_hsa050340.58007360
80* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57693931
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56898107
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55641620
83Huntingtons disease_Homo sapiens_hsa050160.55607521
84* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54920475
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53847890
86Type I diabetes mellitus_Homo sapiens_hsa049400.53789535
87Glucagon signaling pathway_Homo sapiens_hsa049220.51680934
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.51579283
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50107795
90Linoleic acid metabolism_Homo sapiens_hsa005910.49856960
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49767530
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49410158
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48404290
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46730414
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46430614
96Circadian rhythm_Homo sapiens_hsa047100.45917761
97Rap1 signaling pathway_Homo sapiens_hsa040150.45846726
98Renal cell carcinoma_Homo sapiens_hsa052110.45539154
99mTOR signaling pathway_Homo sapiens_hsa041500.45367187
100Ras signaling pathway_Homo sapiens_hsa040140.43831925
101Inositol phosphate metabolism_Homo sapiens_hsa005620.42918891
102Regulation of autophagy_Homo sapiens_hsa041400.42400844
103Vitamin B6 metabolism_Homo sapiens_hsa007500.41769806
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41343917
105Insulin signaling pathway_Homo sapiens_hsa049100.40624867
106ECM-receptor interaction_Homo sapiens_hsa045120.39617622
107Colorectal cancer_Homo sapiens_hsa052100.39520713
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39505877
109Ovarian steroidogenesis_Homo sapiens_hsa049130.38673964
110Endometrial cancer_Homo sapiens_hsa052130.38665412
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.38463414
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38189436
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38053903
114Prolactin signaling pathway_Homo sapiens_hsa049170.37872395
115Wnt signaling pathway_Homo sapiens_hsa043100.37038724
116Hedgehog signaling pathway_Homo sapiens_hsa043400.36482110
117Non-small cell lung cancer_Homo sapiens_hsa052230.33831067
118VEGF signaling pathway_Homo sapiens_hsa043700.32773326
119Prion diseases_Homo sapiens_hsa050200.32365181
120Endocytosis_Homo sapiens_hsa041440.31286918
121Butanoate metabolism_Homo sapiens_hsa006500.27520920
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.26344832

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