CACNA2D3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.93507834
2vocalization behavior (GO:0071625)5.69315976
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.68150631
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.37304745
5synaptic vesicle exocytosis (GO:0016079)5.23686395
6locomotory exploration behavior (GO:0035641)5.20799401
7synaptic vesicle maturation (GO:0016188)5.19866793
8regulation of glutamate receptor signaling pathway (GO:1900449)5.02707284
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.96711844
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.89858053
11protein localization to synapse (GO:0035418)4.89787381
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.88825210
13regulation of cell communication by electrical coupling (GO:0010649)4.83548873
14neuron cell-cell adhesion (GO:0007158)4.74278109
15regulation of synapse structural plasticity (GO:0051823)4.70418346
16regulation of synaptic vesicle exocytosis (GO:2000300)4.65229706
17regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.60933032
18sarcoplasmic reticulum calcium ion transport (GO:0070296)4.58479288
19L-amino acid import (GO:0043092)4.58047707
20glutamate secretion (GO:0014047)4.57578190
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.53797377
22synaptic vesicle docking involved in exocytosis (GO:0016081)4.46850607
23neuron-neuron synaptic transmission (GO:0007270)4.46379882
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.45131611
25neurotransmitter-gated ion channel clustering (GO:0072578)4.42480256
26neuronal action potential propagation (GO:0019227)4.42416528
27regulation of neuronal synaptic plasticity (GO:0048168)4.38435413
28glutamate receptor signaling pathway (GO:0007215)4.38285550
29synaptic transmission, glutamatergic (GO:0035249)4.37090150
30neurotransmitter secretion (GO:0007269)4.36028486
31regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.34338693
32exploration behavior (GO:0035640)4.31589978
33regulation of synaptic vesicle transport (GO:1902803)4.16725087
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.12666428
35muscle filament sliding (GO:0030049)4.07310114
36actin-myosin filament sliding (GO:0033275)4.07310114
37regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.04166400
38prepulse inhibition (GO:0060134)4.04091460
39regulation of excitatory postsynaptic membrane potential (GO:0060079)4.03206588
40cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.02695784
41long-term memory (GO:0007616)3.97373893
42synaptic transmission, dopaminergic (GO:0001963)3.97298529
43regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.92060165
44sodium ion export (GO:0071436)3.91425601
45positive regulation of synapse maturation (GO:0090129)3.91119394
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.89706140
47dendritic spine morphogenesis (GO:0060997)3.88197178
48regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.84598804
49regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.82612633
50potassium ion homeostasis (GO:0055075)3.82378953
51regulation of postsynaptic membrane potential (GO:0060078)3.81924382
52regulation of dendritic spine morphogenesis (GO:0061001)3.81900805
53positive regulation of membrane potential (GO:0045838)3.81857866
54positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.81024970
55layer formation in cerebral cortex (GO:0021819)3.79623713
56positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.77922964
57striatum development (GO:0021756)3.75222401
58regulation of relaxation of muscle (GO:1901077)3.74276010
59amino acid import (GO:0043090)3.72378801
60detection of calcium ion (GO:0005513)3.71728802
61regulation of synaptic transmission, glutamatergic (GO:0051966)3.70135217
62behavioral response to cocaine (GO:0048148)3.69171526
63long-term synaptic potentiation (GO:0060291)3.68840445
64positive regulation of neurotransmitter transport (GO:0051590)3.67373743
65auditory behavior (GO:0031223)3.66333867
66transmission of nerve impulse (GO:0019226)3.65490764
67regulation of synaptic plasticity (GO:0048167)3.65430595
68negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.61400503
69positive regulation of synaptic transmission, GABAergic (GO:0032230)3.60990076
70gamma-aminobutyric acid transport (GO:0015812)3.60139922
71response to histamine (GO:0034776)3.59529051
72gamma-aminobutyric acid signaling pathway (GO:0007214)3.59020501
73cerebellar granule cell differentiation (GO:0021707)3.58111406
74neuron recognition (GO:0008038)3.57735111
75behavioral fear response (GO:0001662)3.57632588
76behavioral defense response (GO:0002209)3.57632588
77positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.54986891
78G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.54308722
79neurotransmitter transport (GO:0006836)3.53411459
80regulation of glutamate secretion (GO:0014048)3.50581589
81response to auditory stimulus (GO:0010996)3.46863014
82positive regulation of neurotransmitter secretion (GO:0001956)3.45345672
83negative regulation of synaptic transmission, GABAergic (GO:0032229)3.45149482
84regulation of female receptivity (GO:0045924)3.43945040
85neuromuscular synaptic transmission (GO:0007274)3.42745994
86cellular potassium ion homeostasis (GO:0030007)3.42396547
87response to amphetamine (GO:0001975)3.42366041
88striated muscle contraction (GO:0006941)3.41384520
89cardiac muscle contraction (GO:0060048)3.40368000
90positive regulation of vesicle fusion (GO:0031340)3.38737784
91cell communication by electrical coupling (GO:0010644)3.38400294
92neuromuscular process controlling balance (GO:0050885)3.37308350
93regulation of neurotransmitter levels (GO:0001505)3.35921882
94potassium ion import (GO:0010107)3.34384801
95fear response (GO:0042596)3.33871048
96G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.32397982
97activation of protein kinase A activity (GO:0034199)3.31641819
98adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.30626339
99cell communication involved in cardiac conduction (GO:0086065)3.30436391
100synaptic vesicle endocytosis (GO:0048488)3.29669377
101membrane hyperpolarization (GO:0060081)3.29134963
102learning (GO:0007612)3.28389850
103presynaptic membrane assembly (GO:0097105)3.28237073
104regulation of neurotransmitter secretion (GO:0046928)3.27898181
105membrane depolarization (GO:0051899)3.26972047
106regulation of membrane repolarization (GO:0060306)3.25538023
107regulation of actin filament-based movement (GO:1903115)3.23828349
108postsynaptic membrane organization (GO:0001941)3.23597765
109mating behavior (GO:0007617)3.21365115
110regulation of vesicle fusion (GO:0031338)3.21292227
111regulation of neurotransmitter transport (GO:0051588)3.21161817
112regulation of calcium ion transmembrane transporter activity (GO:1901019)3.21115136
113regulation of calcium ion transmembrane transport (GO:1903169)3.21115136
114regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.21081080
115regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.21081080
116female mating behavior (GO:0060180)3.18541781
117skeletal muscle contraction (GO:0003009)3.18060449
118proline transport (GO:0015824)3.17271813
119presynaptic membrane organization (GO:0097090)3.17224163
120actin-mediated cell contraction (GO:0070252)3.17100651
121startle response (GO:0001964)3.16751558
122axonal fasciculation (GO:0007413)3.15577306
123dopamine receptor signaling pathway (GO:0007212)3.14770410
124positive regulation of synaptic transmission (GO:0050806)3.14723370
125neuronal ion channel clustering (GO:0045161)3.14519405
126regulation of dendritic spine development (GO:0060998)3.13823138
127synapse assembly (GO:0007416)3.13304593
128membrane depolarization during action potential (GO:0086010)3.12806401
129neuromuscular process (GO:0050905)3.11671879
130regulation of voltage-gated calcium channel activity (GO:1901385)3.11376945
131regulation of synapse maturation (GO:0090128)3.09977987
132synaptic transmission (GO:0007268)3.08127322
133positive regulation of dendritic spine morphogenesis (GO:0061003)3.08089141
134cerebellar Purkinje cell differentiation (GO:0021702)3.06475794
135neurotransmitter uptake (GO:0001504)3.06455575
136negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.05208294
137negative regulation of calcium ion transmembrane transport (GO:1903170)3.05208294
138cardiac muscle hypertrophy (GO:0003300)2.98359148
139neuromuscular process controlling posture (GO:0050884)2.96680524
140regulation of skeletal muscle contraction (GO:0014819)2.86754729
141negative regulation of dendrite morphogenesis (GO:0050774)2.84564257
142striated muscle hypertrophy (GO:0014897)2.82703954
143negative regulation of cytosolic calcium ion concentration (GO:0051481)2.79915308
144positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.79672651
145myofibril assembly (GO:0030239)2.79241224

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.90743728
2* GBX2_23144817_ChIP-Seq_PC3_Human3.76897536
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.24492881
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.22399179
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.17407780
6* RARB_27405468_Chip-Seq_BRAIN_Mouse2.83011761
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75177276
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75177276
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.73685792
10REST_21632747_ChIP-Seq_MESCs_Mouse2.73117405
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.72138545
12* EZH2_27304074_Chip-Seq_ESCs_Mouse2.57743291
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54514388
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53557057
15* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52663784
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.52581077
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.32315765
18* DROSHA_22980978_ChIP-Seq_HELA_Human2.31199901
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29306029
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.23428715
21* REST_18959480_ChIP-ChIP_MESCs_Mouse2.22722721
22* RNF2_27304074_Chip-Seq_ESCs_Mouse2.19597550
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.11256102
24TAF15_26573619_Chip-Seq_HEK293_Human2.10588150
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03718858
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.02303284
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97536092
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96789449
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.92834942
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.92388173
31AR_21572438_ChIP-Seq_LNCaP_Human1.86782284
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85213256
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83543270
34* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70527116
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.69196085
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65028046
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62020676
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.56443179
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53197982
40P300_19829295_ChIP-Seq_ESCs_Human1.51581415
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51567608
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47219898
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41494518
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.40891588
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37081736
46* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36767213
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.34057345
48* SOX2_21211035_ChIP-Seq_LN229_Gbm1.32496854
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30452331
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.29742941
51ZNF274_21170338_ChIP-Seq_K562_Hela1.28875416
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27726742
53* AR_25329375_ChIP-Seq_VCAP_Human1.27643248
54* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25316310
55* STAT3_23295773_ChIP-Seq_U87_Human1.23998177
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.23216457
57RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22785707
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20808403
59* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19339645
60P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18850659
61* PIAS1_25552417_ChIP-Seq_VCAP_Human1.18190485
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17998120
63* AR_19668381_ChIP-Seq_PC3_Human1.17864258
64RNF2_27304074_Chip-Seq_NSC_Mouse1.16032983
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15033719
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12671841
67FUS_26573619_Chip-Seq_HEK293_Human1.11046560
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11046551
69* TCF4_23295773_ChIP-Seq_U87_Human1.09867889
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09837727
71MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08355412
72* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08318226
73* RING1B_27294783_Chip-Seq_NPCs_Mouse1.07603659
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07234547
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.06005294
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05531225
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05026956
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.04888435
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04802730
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04005866
81CBP_20019798_ChIP-Seq_JUKART_Human1.04005866
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03245275
83AHR_22903824_ChIP-Seq_MCF-7_Human1.02510545
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02507640
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02155528
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01217717
87IGF1R_20145208_ChIP-Seq_DFB_Human1.01167067
88* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01033594
89* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00980890
90* RUNX2_22187159_ChIP-Seq_PCA_Human1.00964658
91VDR_22108803_ChIP-Seq_LS180_Human0.98459139
92FLI1_27457419_Chip-Seq_LIVER_Mouse0.97895319
93NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97779757
94EP300_21415370_ChIP-Seq_HL-1_Mouse0.97581651
95SMAD3_21741376_ChIP-Seq_HESCs_Human0.94695799
96JUN_21703547_ChIP-Seq_K562_Human0.93653882
97TP53_16413492_ChIP-PET_HCT116_Human0.93541919
98RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93219365
99ER_23166858_ChIP-Seq_MCF-7_Human0.93139757
100BCAT_22108803_ChIP-Seq_LS180_Human0.92843542
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92471362
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92434040
103SMAD3_21741376_ChIP-Seq_ESCs_Human0.92179322
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90372357
105SMAD4_21741376_ChIP-Seq_HESCs_Human0.89749320
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89499440
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89499440
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89411509
109KDM2B_26808549_Chip-Seq_REH_Human0.89069917
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88911784
111* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88730241
112CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88069398
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87944336
114CTCF_27219007_Chip-Seq_Bcells_Human0.86428189
115NANOG_18555785_Chip-Seq_ESCs_Mouse0.83493503
116TP53_20018659_ChIP-ChIP_R1E_Mouse0.82635157
117E2F1_18555785_Chip-Seq_ESCs_Mouse0.80559358

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.23882593
2MP0003880_abnormal_central_pattern5.20491920
3MP0002822_catalepsy4.68919871
4MP0003635_abnormal_synaptic_transmissio4.21904536
5MP0009745_abnormal_behavioral_response3.65878644
6MP0004270_analgesia3.48105509
7MP0002063_abnormal_learning/memory/cond3.47633132
8MP0002064_seizures3.20172510
9MP0009046_muscle_twitch3.09973866
10MP0001968_abnormal_touch/_nociception2.97460231
11* MP0002572_abnormal_emotion/affect_behav2.90821131
12MP0003646_muscle_fatigue2.80497828
13MP0005423_abnormal_somatic_nervous2.69841922
14MP0002272_abnormal_nervous_system2.68176092
15* MP0001486_abnormal_startle_reflex2.55458391
16MP0002734_abnormal_mechanical_nocicepti2.51419312
17MP0001501_abnormal_sleep_pattern2.39666673
18MP0002736_abnormal_nociception_after2.33573003
19MP0001529_abnormal_vocalization2.30622547
20MP0000749_muscle_degeneration2.23107854
21MP0002735_abnormal_chemical_nociception2.16599927
22MP0001440_abnormal_grooming_behavior2.09935500
23MP0002909_abnormal_adrenal_gland1.96157422
24MP0002067_abnormal_sensory_capabilities1.94899696
25MP0001970_abnormal_pain_threshold1.93665218
26MP0002733_abnormal_thermal_nociception1.93191627
27MP0004036_abnormal_muscle_relaxation1.89092214
28MP0005386_behavior/neurological_phenoty1.86900815
29MP0004924_abnormal_behavior1.86900815
30MP0005646_abnormal_pituitary_gland1.78352452
31MP0006276_abnormal_autonomic_nervous1.75783147
32MP0002184_abnormal_innervation1.75439462
33MP0002557_abnormal_social/conspecific_i1.74321855
34MP0001984_abnormal_olfaction1.71114268
35MP0009780_abnormal_chondrocyte_physiolo1.70513512
36MP0008569_lethality_at_weaning1.69950713
37MP0003329_amyloid_beta_deposits1.69732120
38MP0004084_abnormal_cardiac_muscle1.69171698
39MP0000747_muscle_weakness1.67135333
40MP0004811_abnormal_neuron_physiology1.66466487
41MP0000778_abnormal_nervous_system1.58268390
42MP0003879_abnormal_hair_cell1.58056009
43MP0001905_abnormal_dopamine_level1.50000302
44MP0001188_hyperpigmentation1.46258366
45MP0000955_abnormal_spinal_cord1.44825751
46MP0003787_abnormal_imprinting1.44455457
47MP0004858_abnormal_nervous_system1.43578745
48* MP0002066_abnormal_motor_capabilities/c1.38476695
49MP0000759_abnormal_skeletal_muscle1.38443147
50MP0004130_abnormal_muscle_cell1.36628736
51MP0002882_abnormal_neuron_morphology1.35989262
52MP0004087_abnormal_muscle_fiber1.34276637
53MP0005620_abnormal_muscle_contractility1.30846532
54MP0002106_abnormal_muscle_physiology1.29961598
55MP0002269_muscular_atrophy1.29203139
56MP0002332_abnormal_exercise_endurance1.29156215
57MP0006036_abnormal_mitochondrial_physio1.27569364
58MP0003633_abnormal_nervous_system1.21252771
59MP0004147_increased_porphyrin_level1.20809420
60MP0005645_abnormal_hypothalamus_physiol1.20316049
61MP0001502_abnormal_circadian_rhythm1.20287808
62MP0004885_abnormal_endolymph1.18330526
63MP0008872_abnormal_physiological_respon1.14711446
64MP0004142_abnormal_muscle_tone1.12961125
65MP0005551_abnormal_eye_electrophysiolog1.11687027
66MP0005369_muscle_phenotype1.11140540
67MP0003122_maternal_imprinting1.09599785
68MP0005409_darkened_coat_color1.08335561
69MP0001986_abnormal_taste_sensitivity1.08142512
70MP0000013_abnormal_adipose_tissue1.07689502
71MP0010386_abnormal_urinary_bladder1.06422492
72MP0003631_nervous_system_phenotype1.05311410
73MP0002152_abnormal_brain_morphology1.02984037
74MP0008874_decreased_physiological_sensi1.01424253
75MP0000751_myopathy0.98935145
76MP0002972_abnormal_cardiac_muscle0.98865613
77MP0001177_atelectasis0.97937293
78MP0002069_abnormal_eating/drinking_beha0.96475930
79MP0004085_abnormal_heartbeat0.95834220
80MP0002229_neurodegeneration0.93348091
81MP0005330_cardiomyopathy0.89545205
82MP0005535_abnormal_body_temperature0.88945342
83MP0004510_myositis0.88704303
84MP0004742_abnormal_vestibular_system0.87137790
85MP0005394_taste/olfaction_phenotype0.86154148
86MP0005499_abnormal_olfactory_system0.86154148
87MP0000569_abnormal_digit_pigmentation0.85390294
88MP0002837_dystrophic_cardiac_calcinosis0.84397819
89MP0002090_abnormal_vision0.84261600
90MP0001963_abnormal_hearing_physiology0.76380449
91MP0002752_abnormal_somatic_nervous0.75064728
92MP0003075_altered_response_to0.74964224
93MP0005410_abnormal_fertilization0.74280866
94MP0008961_abnormal_basal_metabolism0.74257794
95MP0000631_abnormal_neuroendocrine_gland0.73644543
96MP0000604_amyloidosis0.73368267
97MP0001664_abnormal_digestion0.72669847
98MP0003632_abnormal_nervous_system0.72354100
99MP0004145_abnormal_muscle_electrophysio0.71195753
100MP0000750_abnormal_muscle_regeneration0.70993867
101MP0001346_abnormal_lacrimal_gland0.69478596
102MP0005166_decreased_susceptibility_to0.69260845
103MP0003634_abnormal_glial_cell0.67528382
104MP0002876_abnormal_thyroid_physiology0.67364530
105MP0002638_abnormal_pupillary_reflex0.66721895
106MP0004215_abnormal_myocardial_fiber0.66344217
107MP0005167_abnormal_blood-brain_barrier0.63302612
108MP0001544_abnormal_cardiovascular_syste0.61953837
109MP0005385_cardiovascular_system_phenoty0.61953837
110MP0000920_abnormal_myelination0.61668753
111MP0003137_abnormal_impulse_conducting0.61657412
112MP0004484_altered_response_of0.61434987
113MP0003690_abnormal_glial_cell0.61319358
114MP0001485_abnormal_pinna_reflex0.60908331
115MP0004233_abnormal_muscle_weight0.58472564
116MP0002102_abnormal_ear_morphology0.57876461
117MP0001943_abnormal_respiration0.56314811
118MP0003283_abnormal_digestive_organ0.55127463
119MP0010769_abnormal_survival0.48647911
120MP0010770_preweaning_lethality0.48153409
121MP0002082_postnatal_lethality0.48153409
122MP0003956_abnormal_body_size0.47532046
123MP0003861_abnormal_nervous_system0.47420324
124MP0005187_abnormal_penis_morphology0.45749049
125MP0000026_abnormal_inner_ear0.45681853
126MP0010768_mortality/aging0.45532352

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.37901148
2Myokymia (HP:0002411)7.54296616
3Focal seizures (HP:0007359)6.00187861
4Muscle fiber inclusion bodies (HP:0100299)5.50208781
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.28248916
6Nemaline bodies (HP:0003798)5.23835498
7Visual hallucinations (HP:0002367)4.98007728
8Epileptic encephalopathy (HP:0200134)4.93204166
9Atonic seizures (HP:0010819)4.83089919
10Febrile seizures (HP:0002373)4.74452868
11Absence seizures (HP:0002121)4.44837376
12Progressive cerebellar ataxia (HP:0002073)4.26959965
13Exercise-induced myalgia (HP:0003738)4.19425306
14Dialeptic seizures (HP:0011146)4.08311779
15Exercise-induced muscle cramps (HP:0003710)4.07755840
16Generalized tonic-clonic seizures (HP:0002069)4.01245527
17Broad-based gait (HP:0002136)3.83677018
18Sudden death (HP:0001699)3.80892848
19Type 1 muscle fiber predominance (HP:0003803)3.80635648
20Muscle hypertrophy of the lower extremities (HP:0008968)3.76085851
21Action tremor (HP:0002345)3.71944444
22Hyperventilation (HP:0002883)3.68604738
23Bundle branch block (HP:0011710)3.66301831
24EMG: myopathic abnormalities (HP:0003458)3.54169618
25Poor eye contact (HP:0000817)3.51824614
26Calf muscle hypertrophy (HP:0008981)3.51376374
27Hyporeflexia of lower limbs (HP:0002600)3.49735980
28Gaze-evoked nystagmus (HP:0000640)3.41262141
29Impaired vibration sensation in the lower limbs (HP:0002166)3.38579982
30Anxiety (HP:0000739)3.34287796
31Dysdiadochokinesis (HP:0002075)3.31893385
32Muscle fiber splitting (HP:0003555)3.29943797
33Depression (HP:0000716)3.27288459
34Impaired social interactions (HP:0000735)3.20242571
35Abnormal social behavior (HP:0012433)3.20242571
36Amblyopia (HP:0000646)3.20174154
37Truncal ataxia (HP:0002078)3.16633846
38Supranuclear gaze palsy (HP:0000605)3.11518249
39Ankle clonus (HP:0011448)3.11170575
40Dysmetria (HP:0001310)3.11051449
41Torticollis (HP:0000473)2.99049723
42Urinary bladder sphincter dysfunction (HP:0002839)2.97554596
43Distal arthrogryposis (HP:0005684)2.93299559
44Abnormal eating behavior (HP:0100738)2.93165969
45Rimmed vacuoles (HP:0003805)2.91366232
46Heart block (HP:0012722)2.87315819
47Frequent falls (HP:0002359)2.85649267
48Limb dystonia (HP:0002451)2.85628631
49Scanning speech (HP:0002168)2.85324045
50Postural instability (HP:0002172)2.83585348
51Centrally nucleated skeletal muscle fibers (HP:0003687)2.81995092
52Abnormality of the calf musculature (HP:0001430)2.78469821
53Progressive inability to walk (HP:0002505)2.76875533
54Myotonia (HP:0002486)2.76683780
55Subaortic stenosis (HP:0001682)2.76300222
56Abnormality of the left ventricular outflow tract (HP:0011103)2.76300222
57Excessive salivation (HP:0003781)2.75212975
58Drooling (HP:0002307)2.75212975
59Focal dystonia (HP:0004373)2.72068442
60Mutism (HP:0002300)2.68774220
61Myopathic facies (HP:0002058)2.67581934
62Urinary urgency (HP:0000012)2.66273230
63Difficulty running (HP:0009046)2.65197310
64Impaired smooth pursuit (HP:0007772)2.65060336
65Stereotypic behavior (HP:0000733)2.64836504
66Calcaneovalgus deformity (HP:0001848)2.60191236
67Cerebral hypomyelination (HP:0006808)2.57133097
68Annular pancreas (HP:0001734)2.56127384
69Muscle stiffness (HP:0003552)2.53578584
70Craniofacial dystonia (HP:0012179)2.52101369
71Epileptiform EEG discharges (HP:0011182)2.51482798
72Abnormal atrioventricular conduction (HP:0005150)2.51472991
73Bradykinesia (HP:0002067)2.51433004
74Papilledema (HP:0001085)2.51190427
75Resting tremor (HP:0002322)2.48465654
76Primary atrial arrhythmia (HP:0001692)2.47296107
77Spastic gait (HP:0002064)2.46385492
78Genetic anticipation (HP:0003743)2.45934215
79Atrial fibrillation (HP:0005110)2.45292870
80Hemiparesis (HP:0001269)2.42685858
81Dysmetric saccades (HP:0000641)2.42221555
82Syncope (HP:0001279)2.39321999
83Cerebral inclusion bodies (HP:0100314)2.37774431
84Supraventricular tachycardia (HP:0004755)2.36510085
85Abnormality of the lower motor neuron (HP:0002366)2.36227241
86Inability to walk (HP:0002540)2.35837506
87Deformed tarsal bones (HP:0008119)2.35461345
88EEG with generalized epileptiform discharges (HP:0011198)2.34090916
89Atrioventricular block (HP:0001678)2.33564020
90Absent speech (HP:0001344)2.33415944
91Asymmetric septal hypertrophy (HP:0001670)2.31953642
92Termporal pattern (HP:0011008)2.29471947
93Insidious onset (HP:0003587)2.29471947
94Abnormality of ocular smooth pursuit (HP:0000617)2.28702360
95Status epilepticus (HP:0002133)2.27230117
96Supraventricular arrhythmia (HP:0005115)2.26286880
97Fetal akinesia sequence (HP:0001989)2.24864275
98Impaired vibratory sensation (HP:0002495)2.23305931
99Neurofibrillary tangles (HP:0002185)2.23279026
100Neck muscle weakness (HP:0000467)2.20947978
101Tetraplegia (HP:0002445)2.20499173
102Abnormality of skeletal muscle fiber size (HP:0012084)2.19842258
103Myoglobinuria (HP:0002913)2.18594096
104Abnormality of binocular vision (HP:0011514)2.18047937
105Diplopia (HP:0000651)2.18047937
106EMG: neuropathic changes (HP:0003445)2.17783845
107Round ear (HP:0100830)2.15641917
108Hypsarrhythmia (HP:0002521)2.15024972
109Ventricular fibrillation (HP:0001663)2.14682527
110Polyphagia (HP:0002591)2.12760645
111Intention tremor (HP:0002080)2.12582696
112Pheochromocytoma (HP:0002666)2.12065399
113Incomplete penetrance (HP:0003829)2.11998481
114Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.11297220
115Protruding tongue (HP:0010808)2.09788794
116Rhabdomyolysis (HP:0003201)2.08757445
117Akinesia (HP:0002304)2.04146974
118Abnormality of the foot musculature (HP:0001436)2.03724480
119Blue irides (HP:0000635)2.03156415
120Acute necrotizing encephalopathy (HP:0006965)2.02983006
121Abnormal mitochondria in muscle tissue (HP:0008316)2.01245837
122Hemiplegia (HP:0002301)2.01202923
123Megalencephaly (HP:0001355)2.01051001
124Abnormal EKG (HP:0003115)2.00962534
125Generalized myoclonic seizures (HP:0002123)2.00895548
126Lower limb muscle weakness (HP:0007340)2.00857122
127Distal lower limb muscle weakness (HP:0009053)2.00715654
128Gait ataxia (HP:0002066)1.99091699
129Lower limb amyotrophy (HP:0007210)1.97539954
130Delusions (HP:0000746)1.96853611
131Foot dorsiflexor weakness (HP:0009027)1.95527941
132Pointed chin (HP:0000307)1.95261572
133Prolonged QT interval (HP:0001657)1.94194984
134Ankyloglossia (HP:0010296)1.88652974
135Gait imbalance (HP:0002141)1.88018770
136Abnormality of the corticospinal tract (HP:0002492)1.87508983
137Abnormality of salivation (HP:0100755)1.84298469
138Neuronal loss in central nervous system (HP:0002529)1.83601702
139Hypoventilation (HP:0002791)1.81568001
140Abnormality of saccadic eye movements (HP:0000570)1.80417213
141Neuroendocrine neoplasm (HP:0100634)1.78858592
142Lower limb asymmetry (HP:0100559)1.78104636
143Psychosis (HP:0000709)1.77369471
144Rigidity (HP:0002063)1.77174451
145Specific learning disability (HP:0001328)1.75353484
146Failure to thrive in infancy (HP:0001531)1.75069294
147Clonus (HP:0002169)1.69309135
148Retinal dysplasia (HP:0007973)1.67116441
149Inappropriate behavior (HP:0000719)1.66310026
150Agitation (HP:0000713)1.63327294

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.69741241
2NTRK34.44668241
3OBSCN4.12573881
4MAP3K93.56141058
5MAP3K43.00441564
6MINK12.66999089
7MAP2K72.56960373
8MARK12.56543868
9DAPK22.50277865
10RIPK42.48187458
11CASK2.27131852
12KSR22.16857132
13MAP3K122.01167048
14NTRK21.99161629
15KSR11.86800270
16PAK61.85450571
17NTRK11.79919406
18MAP2K41.78800253
19DAPK11.71452237
20CAMKK11.64056021
21TTN1.63052674
22PRKD31.62798353
23CDK51.56829227
24ARAF1.55401593
25TNIK1.51710931
26FES1.47762445
27PLK21.46229744
28PRPF4B1.45593550
29MAPK121.44912947
30SIK21.43683449
31PNCK1.39129581
32MAP3K131.37518548
33GRK51.34386415
34MAPK131.20585247
35PRKCG1.18811758
36STK381.17736647
37MAP3K21.14418392
38CDK191.11806586
39BMPR21.10998440
40CAMK2A1.09012976
41CAMKK21.08068353
42UHMK11.04504237
43CAMK2B0.97267563
44TYRO30.96976319
45PTK2B0.95263977
46SGK2230.94504981
47SGK4940.94504981
48RAF10.92556011
49CDK180.91956421
50PKN10.91669497
51SIK30.89602532
52PINK10.88951355
53CDK150.86530327
54TAOK10.86098249
55ERBB30.85951292
56CDK140.85725591
57CAMK10.85569770
58SGK20.81193631
59CDK11A0.74679276
60STK110.73655878
61PRKG10.72580548
62CSNK1G20.70909771
63CAMK1G0.70292986
64MYLK0.70133923
65SGK10.69964729
66RET0.68948964
67PRKCH0.68495572
68NME10.67146309
69MARK20.66219701
70PHKG20.65787730
71PHKG10.65787730
72MOS0.64281329
73PIK3CG0.64068548
74DYRK1A0.64049329
75SGK30.64046735
76OXSR10.61966692
77LATS20.60205306
78CAMK2D0.59858232
79FGR0.59745107
80MAP3K10.57135733
81MAP3K110.55306023
82PRKCE0.54180269
83TNK20.53447519
84PDK10.52985512
85BCR0.52387745
86CAMK2G0.51065098
87PRKCZ0.49986512
88PDPK10.49439001
89MAP2K10.49361694
90LMTK20.49194563
91PDK20.49057473
92BRAF0.47892707
93RPS6KA30.47648227
94PAK30.45731886
95PRKACB0.44936224
96FYN0.44880444
97AKT30.44858112
98MAPK100.42672147
99CCNB10.41720135
100MAPK70.41465887
101CAMK40.40685740
102MAPK40.40557030
103TRPM70.39255145
104NEK10.38896602
105DAPK30.38848928
106PRKCA0.38428948
107GRK70.37392945
108MUSK0.37119057
109FER0.37062317
110ROCK10.36775396
111PRKCB0.36747184
112NEK60.36488114
113ALK0.34334989
114WNK30.34112586
115PRKACA0.33536307
116BLK0.33071172
117MAP2K60.33046789
118WNK10.32906742
119ROCK20.31648299
120CSNK1E0.31226272
121MAP3K70.29959516
122JAK20.28217085

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.97095967
2Synaptic vesicle cycle_Homo sapiens_hsa047213.25404142
3Olfactory transduction_Homo sapiens_hsa047402.98494711
4GABAergic synapse_Homo sapiens_hsa047272.83436126
5Circadian entrainment_Homo sapiens_hsa047132.79300804
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.79213294
7Morphine addiction_Homo sapiens_hsa050322.72986923
8Long-term potentiation_Homo sapiens_hsa047202.72947882
9Amphetamine addiction_Homo sapiens_hsa050312.71250218
10Glutamatergic synapse_Homo sapiens_hsa047242.63463794
11Dopaminergic synapse_Homo sapiens_hsa047282.34996333
12Salivary secretion_Homo sapiens_hsa049702.20185266
13Cholinergic synapse_Homo sapiens_hsa047252.03058169
14Cocaine addiction_Homo sapiens_hsa050302.02550039
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.99234031
16Taste transduction_Homo sapiens_hsa047421.88866759
17Insulin secretion_Homo sapiens_hsa049111.88623568
18Renin secretion_Homo sapiens_hsa049241.85993948
19Serotonergic synapse_Homo sapiens_hsa047261.83580912
20Gastric acid secretion_Homo sapiens_hsa049711.81899207
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78427355
22Long-term depression_Homo sapiens_hsa047301.77323764
23Calcium signaling pathway_Homo sapiens_hsa040201.73894610
24Collecting duct acid secretion_Homo sapiens_hsa049661.67381290
25* Oxytocin signaling pathway_Homo sapiens_hsa049211.66685002
26* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59557718
27Asthma_Homo sapiens_hsa053101.50091359
28GnRH signaling pathway_Homo sapiens_hsa049121.46086752
29Gap junction_Homo sapiens_hsa045401.44584442
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33149471
31* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.31898737
32cAMP signaling pathway_Homo sapiens_hsa040241.29604044
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25870738
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25683944
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23021719
36Phototransduction_Homo sapiens_hsa047441.17536227
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11777121
38Glioma_Homo sapiens_hsa052141.07251126
39Vibrio cholerae infection_Homo sapiens_hsa051101.04169864
40Estrogen signaling pathway_Homo sapiens_hsa049151.03683666
41Huntingtons disease_Homo sapiens_hsa050161.03682810
42Axon guidance_Homo sapiens_hsa043601.03588324
43* Cardiac muscle contraction_Homo sapiens_hsa042601.02075794
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00991388
45Type II diabetes mellitus_Homo sapiens_hsa049300.96997201
46Melanogenesis_Homo sapiens_hsa049160.96700094
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96419328
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.95920571
49ErbB signaling pathway_Homo sapiens_hsa040120.94019848
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90667539
51Regulation of autophagy_Homo sapiens_hsa041400.87213222
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86826829
53Oocyte meiosis_Homo sapiens_hsa041140.85609069
54Pancreatic secretion_Homo sapiens_hsa049720.79512126
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.79059139
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76420740
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74026244
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73239597
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72166512
60Alcoholism_Homo sapiens_hsa050340.70069662
61Thyroid hormone synthesis_Homo sapiens_hsa049180.69906158
62Dorso-ventral axis formation_Homo sapiens_hsa043200.69141373
63Choline metabolism in cancer_Homo sapiens_hsa052310.68770206
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68264308
65Alzheimers disease_Homo sapiens_hsa050100.66691393
66Type I diabetes mellitus_Homo sapiens_hsa049400.65039413
67* Dilated cardiomyopathy_Homo sapiens_hsa054140.63364000
68* MAPK signaling pathway_Homo sapiens_hsa040100.62799529
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61156791
70VEGF signaling pathway_Homo sapiens_hsa043700.59113124
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58822562
72Rap1 signaling pathway_Homo sapiens_hsa040150.58262424
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56669629
74Autoimmune thyroid disease_Homo sapiens_hsa053200.55601648
75Graft-versus-host disease_Homo sapiens_hsa053320.54590174
76Ras signaling pathway_Homo sapiens_hsa040140.54399281
77Oxidative phosphorylation_Homo sapiens_hsa001900.53089905
78Viral myocarditis_Homo sapiens_hsa054160.53043420
79Glucagon signaling pathway_Homo sapiens_hsa049220.52722834
80Tuberculosis_Homo sapiens_hsa051520.52521357
81Parkinsons disease_Homo sapiens_hsa050120.51569951
82Allograft rejection_Homo sapiens_hsa053300.51481650
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.51414034
84African trypanosomiasis_Homo sapiens_hsa051430.49337762
85Inositol phosphate metabolism_Homo sapiens_hsa005620.48626232
86Non-small cell lung cancer_Homo sapiens_hsa052230.47698029
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.46077359
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45008940
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44624501
90Nitrogen metabolism_Homo sapiens_hsa009100.44621731
91Circadian rhythm_Homo sapiens_hsa047100.43541544
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43402484
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40198946
94mTOR signaling pathway_Homo sapiens_hsa041500.39318474
95Bile secretion_Homo sapiens_hsa049760.37120489
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.37102592
97Phagosome_Homo sapiens_hsa041450.36450509
98Endometrial cancer_Homo sapiens_hsa052130.36302665
99Prion diseases_Homo sapiens_hsa050200.36270378
100Wnt signaling pathway_Homo sapiens_hsa043100.35142013
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35124539
102Endocytosis_Homo sapiens_hsa041440.33585863
103beta-Alanine metabolism_Homo sapiens_hsa004100.33123751
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33094694
105Chemokine signaling pathway_Homo sapiens_hsa040620.33077289
106Renal cell carcinoma_Homo sapiens_hsa052110.32633382
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32268198
108* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31798441
109Ovarian steroidogenesis_Homo sapiens_hsa049130.31402925
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29987656
111Arginine biosynthesis_Homo sapiens_hsa002200.29654800
112Insulin signaling pathway_Homo sapiens_hsa049100.29055211
113Leishmaniasis_Homo sapiens_hsa051400.28180293
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27801978
115Rheumatoid arthritis_Homo sapiens_hsa053230.26085451
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26004286
117Arginine and proline metabolism_Homo sapiens_hsa003300.25286222
118Tight junction_Homo sapiens_hsa045300.22988268
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22870216
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19716418

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