CACNB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.98391670
2cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.81701472
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.78236607
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.62362013
5regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.61361929
6regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.46284878
7cellular ketone body metabolic process (GO:0046950)4.37914361
8membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.37903960
9locomotory exploration behavior (GO:0035641)4.25614912
10vocalization behavior (GO:0071625)4.22522279
11cell communication by electrical coupling (GO:0010644)4.21681884
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.20831641
13negative regulation of cytosolic calcium ion concentration (GO:0051481)4.19316029
14synaptic vesicle maturation (GO:0016188)4.17872594
15regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.07041891
16regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.04800626
17synaptic vesicle exocytosis (GO:0016079)3.98693007
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.96797659
19protein localization to synapse (GO:0035418)3.96343952
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.96249516
21regulation of glutamate receptor signaling pathway (GO:1900449)3.93285130
22rhodopsin mediated signaling pathway (GO:0016056)3.90336771
23positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.90172619
24regulation of rhodopsin mediated signaling pathway (GO:0022400)3.88902711
25detection of calcium ion (GO:0005513)3.86445533
26inositol phosphate catabolic process (GO:0071545)3.85311898
27ketone body metabolic process (GO:1902224)3.84458165
28ionotropic glutamate receptor signaling pathway (GO:0035235)3.77543234
29water-soluble vitamin biosynthetic process (GO:0042364)3.75121538
30regulation of synaptic vesicle exocytosis (GO:2000300)3.66349780
31cell communication involved in cardiac conduction (GO:0086065)3.63432749
32glutamate secretion (GO:0014047)3.63385003
33regulation of synapse structural plasticity (GO:0051823)3.63284872
34retinal cone cell development (GO:0046549)3.57244126
35cellular potassium ion homeostasis (GO:0030007)3.55197356
36glutamate receptor signaling pathway (GO:0007215)3.55075371
37cardiac myofibril assembly (GO:0055003)3.54758152
38regulation of membrane repolarization (GO:0060306)3.52782334
39glycerophospholipid catabolic process (GO:0046475)3.51028062
40regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.49202294
41positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.48115355
42neuron-neuron synaptic transmission (GO:0007270)3.47852914
43regulation of voltage-gated calcium channel activity (GO:1901385)3.46761221
44synaptic transmission, glutamatergic (GO:0035249)3.44051062
45striatum development (GO:0021756)3.43480374
46regulation of synaptic vesicle transport (GO:1902803)3.38648066
47response to histamine (GO:0034776)3.37045943
48regulation of excitatory postsynaptic membrane potential (GO:0060079)3.36193631
49neurotransmitter-gated ion channel clustering (GO:0072578)3.35690439
50respiratory chain complex IV assembly (GO:0008535)3.33848147
51membrane depolarization during action potential (GO:0086010)3.33027306
52neuron cell-cell adhesion (GO:0007158)3.32530195
53regulation of postsynaptic membrane potential (GO:0060078)3.32303653
54regulation of cell communication by electrical coupling (GO:0010649)3.31918724
55insulin secretion (GO:0030073)3.31105793
56positive regulation of potassium ion transmembrane transport (GO:1901381)3.28487445
57cardiac muscle contraction (GO:0060048)3.26865290
58G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.25873422
59neurotransmitter secretion (GO:0007269)3.25781748
60sodium ion export (GO:0071436)3.24757115
61exploration behavior (GO:0035640)3.23508449
62long-term memory (GO:0007616)3.22629787
63potassium ion export (GO:0071435)3.20955167
64regulation of calcium ion transmembrane transport (GO:1903169)3.19207579
65regulation of calcium ion transmembrane transporter activity (GO:1901019)3.19207579
66inositol phosphate dephosphorylation (GO:0046855)3.19077364
67phosphorylated carbohydrate dephosphorylation (GO:0046838)3.19077364
68regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.17233888
69neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.17158721
70epithelial cell fate commitment (GO:0072148)3.16991211
71positive regulation of neurotransmitter transport (GO:0051590)3.16837058
72positive regulation of membrane potential (GO:0045838)3.16800912
73regulation of long-term neuronal synaptic plasticity (GO:0048169)3.15854296
74proline transport (GO:0015824)3.15484321
75regulation of neuronal synaptic plasticity (GO:0048168)3.11367919
76cardiac conduction (GO:0061337)3.11049900
77positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.08975700
78membrane hyperpolarization (GO:0060081)3.08850674
79cerebellar Purkinje cell differentiation (GO:0021702)3.08481157
80presynaptic membrane assembly (GO:0097105)3.08304882
81cytochrome complex assembly (GO:0017004)3.05992603
82negative regulation of potassium ion transmembrane transport (GO:1901380)3.04237751
83detection of light stimulus involved in visual perception (GO:0050908)3.03223841
84detection of light stimulus involved in sensory perception (GO:0050962)3.03223841
85response to pheromone (GO:0019236)3.02997649
86positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.02575674
87positive regulation of synapse maturation (GO:0090129)3.02229447
88relaxation of cardiac muscle (GO:0055119)3.01307588
89photoreceptor cell development (GO:0042461)2.99522247
90neuronal action potential propagation (GO:0019227)2.99179193
91regulation of neurotransmitter uptake (GO:0051580)2.98976513
92positive regulation of neurotransmitter secretion (GO:0001956)2.98485379
93C4-dicarboxylate transport (GO:0015740)2.97409692
94presynaptic membrane organization (GO:0097090)2.97074685
95potassium ion import (GO:0010107)2.96498340
96regulation of heart rate by cardiac conduction (GO:0086091)2.96476632
97polyol catabolic process (GO:0046174)2.96106143
98membrane repolarization (GO:0086009)2.95483723
99dendritic spine morphogenesis (GO:0060997)2.95272401
100behavioral response to cocaine (GO:0048148)2.94884965
101sarcoplasmic reticulum calcium ion transport (GO:0070296)2.93091858
102negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.92275432
103membrane depolarization (GO:0051899)2.91848645
104behavioral defense response (GO:0002209)2.91536301
105behavioral fear response (GO:0001662)2.91536301
106membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.91123344
107gamma-aminobutyric acid signaling pathway (GO:0007214)2.91063571
108regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.90456021
109regulation of dendritic spine morphogenesis (GO:0061001)2.90436333
110synaptic vesicle endocytosis (GO:0048488)2.89952166
111eye photoreceptor cell development (GO:0042462)2.89316158
112innervation (GO:0060384)2.88266721
113potassium ion homeostasis (GO:0055075)2.88169136
114activation of protein kinase A activity (GO:0034199)2.87353537
115photoreceptor cell maintenance (GO:0045494)2.86452954
116chemosensory behavior (GO:0007635)2.86397895
117regulation of synaptic transmission, glutamatergic (GO:0051966)2.85526683
118regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.85417641
119multicellular organismal signaling (GO:0035637)2.84535598
120gamma-aminobutyric acid transport (GO:0015812)2.84475543
121myofibril assembly (GO:0030239)2.83902729
122startle response (GO:0001964)2.83128842
123establishment of protein localization to Golgi (GO:0072600)2.81158070
124regulation of protein glycosylation (GO:0060049)2.77994786
125aggressive behavior (GO:0002118)2.77737487
126protein targeting to Golgi (GO:0000042)2.75577994
127endocrine pancreas development (GO:0031018)2.75482573
128regulation of acyl-CoA biosynthetic process (GO:0050812)2.74479357
129regulation of type B pancreatic cell apoptotic process (GO:2000674)2.73582147
130neuronal action potential (GO:0019228)2.72021001
131auditory receptor cell differentiation (GO:0042491)2.70423238
132action potential (GO:0001508)2.69991000
133negative regulation of response to food (GO:0032096)2.68441307
134negative regulation of appetite (GO:0032099)2.68441307
135alanine transport (GO:0032328)2.66772394
136nitric oxide mediated signal transduction (GO:0007263)2.65910056
137renal tubule morphogenesis (GO:0061333)2.65041029
138retrograde transport, vesicle recycling within Golgi (GO:0000301)2.63279017
139positive regulation of meiosis (GO:0045836)2.63126394
140behavioral response to nicotine (GO:0035095)2.61898788
141protein prenylation (GO:0018342)2.61742650
142prenylation (GO:0097354)2.61742650
143negative regulation of execution phase of apoptosis (GO:1900118)2.61510271
144protein complex biogenesis (GO:0070271)2.61322281
145peptide hormone processing (GO:0016486)2.59386941
146regulation of hexokinase activity (GO:1903299)2.58160579
147regulation of glucokinase activity (GO:0033131)2.58160579
148atrial cardiac muscle cell action potential (GO:0086014)2.58026154
149auditory behavior (GO:0031223)2.57272511
150dentate gyrus development (GO:0021542)2.56334240
151detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.56305771
152positive regulation of histone H3-K4 methylation (GO:0051571)2.56268743
153inositol phosphate-mediated signaling (GO:0048016)2.54711464
154vascular smooth muscle contraction (GO:0014829)2.51944738
155neuromuscular process controlling posture (GO:0050884)2.50665347
156protein K6-linked ubiquitination (GO:0085020)2.48067256
157negative regulation of dendrite development (GO:2000171)2.46922608
158axoneme assembly (GO:0035082)2.46383456
159serotonin metabolic process (GO:0042428)2.45983046
160regulation of cilium movement (GO:0003352)2.45914974
161kidney morphogenesis (GO:0060993)2.44272824
162positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.43711922
163protein polyglutamylation (GO:0018095)2.43029152
164positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.42085358
165positive regulation of meiotic cell cycle (GO:0051446)2.41931348
166nephron tubule morphogenesis (GO:0072078)2.41261020
167nephron epithelium morphogenesis (GO:0072088)2.41261020
168fucose catabolic process (GO:0019317)2.39749015
169L-fucose metabolic process (GO:0042354)2.39749015
170L-fucose catabolic process (GO:0042355)2.39749015
171reflex (GO:0060004)2.39634634
172positive regulation of insulin secretion (GO:0032024)2.39208190
173xenobiotic catabolic process (GO:0042178)2.37916881
174positive regulation of vascular permeability (GO:0043117)2.37368685
175negative regulation of hormone biosynthetic process (GO:0032353)2.37297122
176mechanosensory behavior (GO:0007638)2.37004709

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.54232472
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.24249682
3GBX2_23144817_ChIP-Seq_PC3_Human3.85679700
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.75541749
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.74563971
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.61501447
7DROSHA_22980978_ChIP-Seq_HELA_Human2.50862191
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.34237094
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.34237094
10* RARB_27405468_Chip-Seq_BRAIN_Mouse2.29880220
11REST_21632747_ChIP-Seq_MESCs_Mouse2.29626927
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28130724
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26296720
14* EZH2_27304074_Chip-Seq_ESCs_Mouse2.23588233
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21582253
16* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20399091
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18240788
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15285275
19* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.12324210
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07708511
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.05875831
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98740780
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.96676654
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.94188947
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93429486
26* RNF2_27304074_Chip-Seq_ESCs_Mouse1.90986481
27* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88787444
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87215832
29* SMAD4_21799915_ChIP-Seq_A2780_Human1.85370652
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.84497076
31EWS_26573619_Chip-Seq_HEK293_Human1.84147487
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.83417213
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72746345
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.70645317
35* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68281552
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67524261
37TAF15_26573619_Chip-Seq_HEK293_Human1.66292227
38* EP300_21415370_ChIP-Seq_HL-1_Mouse1.63367231
39AR_21572438_ChIP-Seq_LNCaP_Human1.62772375
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57411522
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.51860093
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50472944
43EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.49943085
44ZNF274_21170338_ChIP-Seq_K562_Hela1.47039267
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.45035284
46P300_19829295_ChIP-Seq_ESCs_Human1.43877268
47STAT3_23295773_ChIP-Seq_U87_Human1.43241217
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41593698
49* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41347719
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41059533
51* SOX2_21211035_ChIP-Seq_LN229_Gbm1.40771327
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40732057
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.38681751
54CBP_20019798_ChIP-Seq_JUKART_Human1.37369306
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37369306
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.37182778
57* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35324555
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.34789576
59* AR_19668381_ChIP-Seq_PC3_Human1.33575811
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33133574
61RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31655384
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.31190630
63* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30053947
64IGF1R_20145208_ChIP-Seq_DFB_Human1.29922065
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.29375464
66* TCF4_23295773_ChIP-Seq_U87_Human1.28187400
67RNF2_27304074_Chip-Seq_NSC_Mouse1.27419571
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25353168
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25329641
70* TCF4_22108803_ChIP-Seq_LS180_Human1.24513581
71TP53_22573176_ChIP-Seq_HFKS_Human1.23292244
72AR_25329375_ChIP-Seq_VCAP_Human1.22342421
73* P53_22387025_ChIP-Seq_ESCs_Mouse1.22074856
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21717018
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20459036
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20313959
77HTT_18923047_ChIP-ChIP_STHdh_Human1.20292337
78* CDX2_22108803_ChIP-Seq_LS180_Human1.19959200
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.19862223
80WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17773785
81SMAD3_21741376_ChIP-Seq_HESCs_Human1.17649172
82P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17593438
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17122665
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16926235
85* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16334071
86RING1B_27294783_Chip-Seq_ESCs_Mouse1.16299353
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.15945582
88MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14959583
89* SOX2_19829295_ChIP-Seq_ESCs_Human1.14685652
90* NANOG_19829295_ChIP-Seq_ESCs_Human1.14685652
91ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14340999
92YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13241180
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12374158
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12093923
95* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12046151
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11607338
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11417990
98* E2F1_18555785_Chip-Seq_ESCs_Mouse1.10992651
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10930386
100TAL1_26923725_Chip-Seq_HPCs_Mouse1.10212056
101SMAD4_21741376_ChIP-Seq_EPCs_Human1.10164731
102TP53_16413492_ChIP-PET_HCT116_Human1.10062248
103FUS_26573619_Chip-Seq_HEK293_Human1.09519967
104AHR_22903824_ChIP-Seq_MCF-7_Human1.09137660
105* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08494382
106ARNT_22903824_ChIP-Seq_MCF-7_Human1.08485767
107* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08022018
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07466828
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07338011
110VDR_22108803_ChIP-Seq_LS180_Human1.06548969
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05972115
112* CMYC_18555785_Chip-Seq_ESCs_Mouse1.05879764
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05636339
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05189235
115* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05141725
116* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04111041
117* STAT3_18555785_Chip-Seq_ESCs_Mouse1.03292161
118HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02982761
119* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02941009
120SMAD4_21741376_ChIP-Seq_HESCs_Human1.02274394
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02127702
122RUNX2_22187159_ChIP-Seq_PCA_Human1.01825480
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01114118
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01114118
125* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01111677
126CRX_20693478_ChIP-Seq_RETINA_Mouse1.00897697
127* SOX2_18555785_Chip-Seq_ESCs_Mouse1.00677840
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00580425
129* BCAT_22108803_ChIP-Seq_LS180_Human1.00450232
130TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00181497
131NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98936876
132* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98821157
133RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98082716
134* PRDM14_20953172_ChIP-Seq_ESCs_Human0.97636826
135* NANOG_18555785_Chip-Seq_ESCs_Mouse0.97432625
136VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95521586
137LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94744854
138* RING1B_27294783_Chip-Seq_NPCs_Mouse0.94280662
139SMAD3_21741376_ChIP-Seq_ESCs_Human0.93038792
140ER_23166858_ChIP-Seq_MCF-7_Human0.92171897

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.65931314
2MP0003880_abnormal_central_pattern3.75183358
3MP0002837_dystrophic_cardiac_calcinosis3.27748008
4* MP0005551_abnormal_eye_electrophysiolog3.26699909
5MP0003635_abnormal_synaptic_transmissio3.17628849
6* MP0004215_abnormal_myocardial_fiber2.77110596
7MP0009745_abnormal_behavioral_response2.71281585
8MP0002822_catalepsy2.69816660
9MP0000751_myopathy2.60923388
10MP0004084_abnormal_cardiac_muscle2.55624815
11MP0005379_endocrine/exocrine_gland_phen2.55301984
12MP0002063_abnormal_learning/memory/cond2.52062893
13MP0004270_analgesia2.49645979
14MP0002064_seizures2.45168912
15MP0009046_muscle_twitch2.39991934
16MP0003646_muscle_fatigue2.34327363
17MP0003195_calcinosis2.31888517
18MP0006072_abnormal_retinal_apoptosis2.31814471
19MP0005423_abnormal_somatic_nervous2.31769091
20MP0003283_abnormal_digestive_organ2.30835692
21MP0008877_abnormal_DNA_methylation2.23095761
22MP0002572_abnormal_emotion/affect_behav2.22180304
23MP0001968_abnormal_touch/_nociception2.22090721
24MP0002272_abnormal_nervous_system2.20287318
25MP0001486_abnormal_startle_reflex2.19831146
26MP0004145_abnormal_muscle_electrophysio2.16111683
27MP0004036_abnormal_muscle_relaxation2.12204239
28MP0002909_abnormal_adrenal_gland1.97779475
29* MP0005253_abnormal_eye_physiology1.89885183
30MP0002163_abnormal_gland_morphology1.86568295
31MP0003137_abnormal_impulse_conducting1.85371323
32MP0009780_abnormal_chondrocyte_physiolo1.83502648
33* MP0004085_abnormal_heartbeat1.83502239
34MP0002734_abnormal_mechanical_nocicepti1.82235855
35MP0001501_abnormal_sleep_pattern1.76342879
36MP0002067_abnormal_sensory_capabilities1.68136772
37MP0005646_abnormal_pituitary_gland1.66839191
38MP0000749_muscle_degeneration1.66273799
39MP0005330_cardiomyopathy1.65655768
40MP0001944_abnormal_pancreas_morphology1.64962438
41MP0002735_abnormal_chemical_nociception1.61818829
42MP0002736_abnormal_nociception_after1.61578199
43MP0001984_abnormal_olfaction1.60740583
44MP0004924_abnormal_behavior1.59749894
45MP0005386_behavior/neurological_phenoty1.59749894
46MP0004484_altered_response_of1.57721582
47MP0004233_abnormal_muscle_weight1.57638088
48MP0005620_abnormal_muscle_contractility1.53403697
49MP0002972_abnormal_cardiac_muscle1.53209058
50MP0004510_myositis1.52478918
51MP0008569_lethality_at_weaning1.49879308
52MP0002693_abnormal_pancreas_physiology1.48806390
53MP0001502_abnormal_circadian_rhythm1.48134288
54MP0001440_abnormal_grooming_behavior1.48049757
55MP0003011_delayed_dark_adaptation1.46657034
56MP0002876_abnormal_thyroid_physiology1.44659852
57MP0002090_abnormal_vision1.40859079
58* MP0002229_neurodegeneration1.36818539
59MP0002102_abnormal_ear_morphology1.35829370
60MP0003879_abnormal_hair_cell1.35447862
61MP0008775_abnormal_heart_ventricle1.33839977
62MP0003121_genomic_imprinting1.33612468
63MP0001970_abnormal_pain_threshold1.32992465
64MP0002184_abnormal_innervation1.31050876
65MP0002557_abnormal_social/conspecific_i1.30146002
66MP0010329_abnormal_lipoprotein_level1.29910644
67MP0003787_abnormal_imprinting1.26432400
68* MP0002882_abnormal_neuron_morphology1.26113464
69MP0005220_abnormal_exocrine_pancreas1.25705587
70MP0001529_abnormal_vocalization1.25125742
71MP0004087_abnormal_muscle_fiber1.22020523
72MP0001188_hyperpigmentation1.20740050
73MP0003950_abnormal_plasma_membrane1.19705287
74MP0005332_abnormal_amino_acid1.19200062
75MP0002254_reproductive_system_inflammat1.17998196
76MP0002638_abnormal_pupillary_reflex1.17956455
77MP0003122_maternal_imprinting1.16753475
78MP0001485_abnormal_pinna_reflex1.16562559
79MP0002733_abnormal_thermal_nociception1.15620235
80MP0006276_abnormal_autonomic_nervous1.14569108
81MP0000003_abnormal_adipose_tissue1.11944009
82MP0001765_abnormal_ion_homeostasis1.11568952
83MP0005174_abnormal_tail_pigmentation1.10944347
84MP0000569_abnormal_digit_pigmentation1.09422653
85MP0004811_abnormal_neuron_physiology1.09320039
86MP0000013_abnormal_adipose_tissue1.08020769
87* MP0005195_abnormal_posterior_eye1.06633256
88MP0002078_abnormal_glucose_homeostasis1.05861612
89MP0002066_abnormal_motor_capabilities/c1.05289941
90MP0004130_abnormal_muscle_cell1.04796234
91MP0005084_abnormal_gallbladder_morpholo1.04121760
92MP0001986_abnormal_taste_sensitivity1.02691198
93MP0005636_abnormal_mineral_homeostasis1.02573160
94MP0005448_abnormal_energy_balance1.01222808
95MP0000639_abnormal_adrenal_gland1.00842831
96MP0002106_abnormal_muscle_physiology1.00838738
97MP0006138_congestive_heart_failure0.99602811
98MP0001756_abnormal_urination0.98700789
99MP0002234_abnormal_pharynx_morphology0.98259662
100MP0010386_abnormal_urinary_bladder0.97467857
101MP0004019_abnormal_vitamin_homeostasis0.97158692
102MP0004142_abnormal_muscle_tone0.97056034
103MP0004043_abnormal_pH_regulation0.96212762
104* MP0002752_abnormal_somatic_nervous0.96063388
105MP0002269_muscular_atrophy0.95400245
106MP0000747_muscle_weakness0.94916076
107MP0003633_abnormal_nervous_system0.94749023
108MP0000778_abnormal_nervous_system0.94634113
109MP0000955_abnormal_spinal_cord0.93121869
110MP0002928_abnormal_bile_duct0.92633319
111MP0000427_abnormal_hair_cycle0.91913535
112MP0008872_abnormal_physiological_respon0.91575505
113MP0000230_abnormal_systemic_arterial0.91549841
114MP0002938_white_spotting0.90935766
115* MP0005385_cardiovascular_system_phenoty0.88577013
116* MP0001544_abnormal_cardiovascular_syste0.88577013
117MP0003953_abnormal_hormone_level0.87643571
118MP0004885_abnormal_endolymph0.87478600
119MP0005645_abnormal_hypothalamus_physiol0.86109637
120MP0005187_abnormal_penis_morphology0.84421140
121MP0010630_abnormal_cardiac_muscle0.83593695
122MP0005369_muscle_phenotype0.83558335
123MP0006036_abnormal_mitochondrial_physio0.83424704
124MP0000383_abnormal_hair_follicle0.83379070
125MP0003252_abnormal_bile_duct0.83149073
126MP0010678_abnormal_skin_adnexa0.82417832
127MP0004133_heterotaxia0.82210761
128MP0002139_abnormal_hepatobiliary_system0.82085799
129MP0000759_abnormal_skeletal_muscle0.81766938
130MP0002069_abnormal_eating/drinking_beha0.80269621
131MP0005367_renal/urinary_system_phenotyp0.80265654
132MP0000516_abnormal_urinary_system0.80265654
133MP0001905_abnormal_dopamine_level0.80146256
134MP0003631_nervous_system_phenotype0.77100696
135MP0005409_darkened_coat_color0.76096932
136MP0000631_abnormal_neuroendocrine_gland0.75727689
137MP0005535_abnormal_body_temperature0.74327115
138MP0002332_abnormal_exercise_endurance0.72502966
139MP0008874_decreased_physiological_sensi0.71168436
140* MP0002127_abnormal_cardiovascular_syste0.71099509
141* MP0002152_abnormal_brain_morphology0.70612209
142MP0008961_abnormal_basal_metabolism0.70480776
143MP0001963_abnormal_hearing_physiology0.70236554

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)6.17172224
2Focal motor seizures (HP:0011153)5.76813150
3Central scotoma (HP:0000603)5.27086025
4Sudden death (HP:0001699)4.80733478
5Bony spicule pigmentary retinopathy (HP:0007737)4.67072379
6* Atrial fibrillation (HP:0005110)4.14782727
7Febrile seizures (HP:0002373)4.13606888
8Prolonged QT interval (HP:0001657)4.13580956
9Epileptic encephalopathy (HP:0200134)4.05472826
10Scotoma (HP:0000575)4.05115841
11Focal seizures (HP:0007359)4.01933680
12Abnormality of macular pigmentation (HP:0008002)3.99104431
13* Primary atrial arrhythmia (HP:0001692)3.95859656
14Myokymia (HP:0002411)3.89334021
15Abnormal rod and cone electroretinograms (HP:0008323)3.85010308
16* Syncope (HP:0001279)3.79561143
17* Supraventricular tachycardia (HP:0004755)3.73791674
18Visual hallucinations (HP:0002367)3.72269315
19Absent rod-and cone-mediated responses on ERG (HP:0007688)3.69704563
20Intestinal atresia (HP:0011100)3.67491889
21* Supraventricular arrhythmia (HP:0005115)3.62110075
22Hemiparesis (HP:0001269)3.51510971
23Dyschromatopsia (HP:0007641)3.51369607
24Ventricular fibrillation (HP:0001663)3.44293953
25Renal cortical cysts (HP:0000803)3.35003679
26Calf muscle hypertrophy (HP:0008981)3.32436900
27Absence seizures (HP:0002121)3.32238275
28Progressive cerebellar ataxia (HP:0002073)3.29644984
29Atonic seizures (HP:0010819)3.26952589
30Medial flaring of the eyebrow (HP:0010747)3.20730194
31Bundle branch block (HP:0011710)3.20432079
32Hypothermia (HP:0002045)3.14738245
33* Abnormal EKG (HP:0003115)3.07126466
34Dysmetric saccades (HP:0000641)3.05882423
35True hermaphroditism (HP:0010459)3.05690269
36Abnormality of the renal cortex (HP:0011035)3.04042468
37Abnormality of the calf musculature (HP:0001430)3.03629242
38Attenuation of retinal blood vessels (HP:0007843)3.02850317
39Pancreatic fibrosis (HP:0100732)3.01452814
40Generalized tonic-clonic seizures (HP:0002069)3.01222785
41Broad-based gait (HP:0002136)3.00783097
42Dialeptic seizures (HP:0011146)2.99994917
43Muscle hypertrophy of the lower extremities (HP:0008968)2.98773998
44Dysdiadochokinesis (HP:0002075)2.97195878
45Exercise-induced myalgia (HP:0003738)2.94133267
46Pancreatic cysts (HP:0001737)2.92186850
47Gaze-evoked nystagmus (HP:0000640)2.91269898
48Ventricular tachycardia (HP:0004756)2.83132912
49Decreased central vision (HP:0007663)2.80743742
50Hyperventilation (HP:0002883)2.80624329
51Truncal ataxia (HP:0002078)2.77587920
52Large for gestational age (HP:0001520)2.77360938
53Ventricular arrhythmia (HP:0004308)2.76822942
54Hypoglycemic seizures (HP:0002173)2.73012979
55Type II lissencephaly (HP:0007260)2.72354444
56Pigmentary retinal degeneration (HP:0001146)2.72178578
57Hypoglycemic coma (HP:0001325)2.70685965
58Left ventricular hypertrophy (HP:0001712)2.67930913
59Chorioretinal atrophy (HP:0000533)2.67211643
60Abnormality of vitamin B metabolism (HP:0004340)2.66773765
61Polydipsia (HP:0001959)2.66336477
62Abnormal drinking behavior (HP:0030082)2.66336477
63Double outlet right ventricle (HP:0001719)2.66209954
64Congenital malformation of the right heart (HP:0011723)2.66209954
65Molar tooth sign on MRI (HP:0002419)2.64135387
66Abnormality of midbrain morphology (HP:0002418)2.64135387
67Ketoacidosis (HP:0001993)2.63796075
68Poor eye contact (HP:0000817)2.59672010
69Nephronophthisis (HP:0000090)2.57521263
70Methylmalonic acidemia (HP:0002912)2.54945523
71Depression (HP:0000716)2.54586024
72Genetic anticipation (HP:0003743)2.54482544
73Generalized aminoaciduria (HP:0002909)2.53129125
74Progressive macrocephaly (HP:0004481)2.48247891
75Heart block (HP:0012722)2.47200039
76Abnormal social behavior (HP:0012433)2.41111314
77Impaired social interactions (HP:0000735)2.41111314
78Pendular nystagmus (HP:0012043)2.41085071
79Action tremor (HP:0002345)2.40644813
80Anxiety (HP:0000739)2.39141401
81Type II diabetes mellitus (HP:0005978)2.37029800
82Hyperglycemia (HP:0003074)2.36152742
83Urinary bladder sphincter dysfunction (HP:0002839)2.35741042
84Agitation (HP:0000713)2.33211157
85Abnormality of urine glucose concentration (HP:0011016)2.29934947
86Glycosuria (HP:0003076)2.29934947
87Congenital primary aphakia (HP:0007707)2.28428809
88Decreased circulating renin level (HP:0003351)2.27412835
89Postural instability (HP:0002172)2.25850459
90Atrioventricular block (HP:0001678)2.25582934
91Hyperinsulinemic hypoglycemia (HP:0000825)2.24751207
92Acute necrotizing encephalopathy (HP:0006965)2.23027243
93Abnormal atrioventricular conduction (HP:0005150)2.22872343
94Exercise-induced muscle cramps (HP:0003710)2.21671755
95Severe visual impairment (HP:0001141)2.21543980
96Abnormality of the renal medulla (HP:0100957)2.20164075
97Lipoatrophy (HP:0100578)2.15992640
98Photophobia (HP:0000613)2.15854460
99Dysmetria (HP:0001310)2.14985906
100Hepatic necrosis (HP:0002605)2.14183995
101Abolished electroretinogram (ERG) (HP:0000550)2.13250041
102Excessive salivation (HP:0003781)2.12596949
103Drooling (HP:0002307)2.12596949
104Ketosis (HP:0001946)2.12398058
105Abnormality of the left ventricular outflow tract (HP:0011103)2.11151846
106Subaortic stenosis (HP:0001682)2.11151846
107Choroideremia (HP:0001139)2.10407447
108Pheochromocytoma (HP:0002666)2.09754693
109Abnormality of aromatic amino acid family metabolism (HP:0004338)2.08459821
110Mitochondrial inheritance (HP:0001427)2.07545009
111Furrowed tongue (HP:0000221)2.06145865
112Abnormal hair whorl (HP:0010721)2.05581231
113Nephrogenic diabetes insipidus (HP:0009806)2.04480594
114Palpitations (HP:0001962)2.03128534
115Impaired smooth pursuit (HP:0007772)2.02578571
116Epileptiform EEG discharges (HP:0011182)2.01924308
117Methylmalonic aciduria (HP:0012120)2.01377690
118Abnormality of vitamin metabolism (HP:0100508)2.00638588
119Impaired vibration sensation in the lower limbs (HP:0002166)1.99674272
120Polyuria (HP:0000103)1.97008454
121Retinitis pigmentosa (HP:0000510)1.95986170
122Acute encephalopathy (HP:0006846)1.95920869
123Renal Fanconi syndrome (HP:0001994)1.94971030
124Increased CSF lactate (HP:0002490)1.94412974
125Right ventricular cardiomyopathy (HP:0011663)1.94177709
126Tongue fasciculations (HP:0001308)1.93281681
127Decreased electroretinogram (ERG) amplitude (HP:0000654)1.93147267
128Congenital hepatic fibrosis (HP:0002612)1.92995542
129Bradycardia (HP:0001662)1.92624081
130Genital tract atresia (HP:0001827)1.91727229
131Scanning speech (HP:0002168)1.91624300
132Gastrointestinal atresia (HP:0002589)1.89868815
133EEG with generalized epileptiform discharges (HP:0011198)1.89516512
134Hypomagnesemia (HP:0002917)1.88655441
135Abnormality of renal resorption (HP:0011038)1.87098020
136Inability to walk (HP:0002540)1.85692495
137Insulin-resistant diabetes mellitus (HP:0000831)1.85412388
138Aqueductal stenosis (HP:0002410)1.84235815
139Hepatocellular necrosis (HP:0001404)1.84094854
140Cystic liver disease (HP:0006706)1.83755634
141Dilated cardiomyopathy (HP:0001644)1.83103112
142Neoplasm of the adrenal cortex (HP:0100641)1.82354802
143EMG: myopathic abnormalities (HP:0003458)1.81402081
144Myoglobinuria (HP:0002913)1.81000295
145Hypoalbuminemia (HP:0003073)1.79560414
146Abnormal albumin level (HP:0012116)1.79560414
147Vaginal atresia (HP:0000148)1.79508943
148Bradykinesia (HP:0002067)1.78870473
149Neuroendocrine neoplasm (HP:0100634)1.77980170
150Optic disc pallor (HP:0000543)1.77488073
151Abnormality of calcium-phosphate metabolism (HP:0100530)1.77474348
152Enlarged penis (HP:0000040)1.77397351
153Increased corneal curvature (HP:0100692)1.77382472
154Keratoconus (HP:0000563)1.77382472
155Congenital sensorineural hearing impairment (HP:0008527)1.77378308
156Protruding tongue (HP:0010808)1.77303606
157Cerebellar dysplasia (HP:0007033)1.76862434
158Progressive inability to walk (HP:0002505)1.76508983
159Lower limb amyotrophy (HP:0007210)1.75914080
160Failure to thrive in infancy (HP:0001531)1.75746373
161Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.75615634
162Hyperalaninemia (HP:0003348)1.75615634
163Supranuclear gaze palsy (HP:0000605)1.75511638
164Constricted visual fields (HP:0001133)1.75194895
165Absent speech (HP:0001344)1.74913835
166Gait imbalance (HP:0002141)1.74776067
167Ankle clonus (HP:0011448)1.72876278
168Abnormality of ocular smooth pursuit (HP:0000617)1.72015414
169Hyporeflexia of lower limbs (HP:0002600)1.71360830

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.12185838
2NTRK34.38066882
3BMPR1B4.21799044
4EPHA44.17510418
5MAP3K42.84119022
6MAP3K92.62985497
7MAP2K72.23134613
8TAOK32.19804837
9FGFR22.11367961
10PRKD32.11297096
11MAP4K22.08415596
12TNIK1.96936062
13INSRR1.88340519
14ADRBK21.86581735
15MINK11.75234276
16PHKG21.74976796
17PHKG11.74976796
18PINK11.73560388
19ACVR1B1.71442748
20OBSCN1.70841035
21MUSK1.70575991
22PAK61.70063734
23NUAK11.70047781
24STK381.69974849
25DAPK21.63284004
26MARK11.63251134
27CASK1.63022121
28KSR21.62548192
29LMTK21.60259751
30DMPK1.59097141
31MAP2K41.57494662
32MKNK21.55038114
33RIPK41.53110319
34MST41.49344663
35NTRK21.47517280
36MYLK1.45749301
37CAMKK11.39739498
38CAMK2A1.36605506
39CAMK11.32345245
40KSR11.30792091
41CAMKK21.28650654
42OXSR11.27412151
43PRPF4B1.27399295
44GRK11.24749275
45CDK51.24248930
46SIK21.19476292
47FES1.18165801
48WNK11.16990507
49CDC42BPA1.16844899
50MAP3K131.15932228
51FLT31.15059875
52* CAMK2D1.13902868
53STK391.12552008
54MAP2K61.12469638
55MAPK131.12427856
56PAK31.12376073
57GRK51.10432912
58GRK71.07831889
59SGK21.06505706
60STK38L1.06227916
61DAPK11.00269028
62SGK2230.99106425
63SGK4940.99106425
64CAMK1G0.98062364
65PLK20.97199731
66AKT30.93694908
67CSNK1G10.92953366
68FGFR30.92509727
69PRKCH0.91487040
70NTRK10.91022884
71SGK30.90598231
72SGK10.88591079
73CSNK1G30.88250951
74UHMK10.87755528
75PRKCG0.87123405
76MAP3K70.86343330
77CAMK2B0.86249764
78CSNK1G20.86017623
79STK240.85767802
80IRAK10.85745427
81MAP3K120.83625482
82PTK2B0.81798616
83NEK10.81756874
84CAMK40.77263790
85STK110.76779914
86ERBB30.76368242
87ZAK0.76358757
88PNCK0.75747493
89PRKG20.75203821
90TTN0.73877450
91PIK3CA0.73806285
92PRKCE0.71735878
93MAP3K20.70942350
94WNK40.70019098
95RET0.69681408
96RAF10.68375232
97EIF2AK30.64090058
98RPS6KA30.62883805
99PDK40.62821770
100PDK30.62821770
101NLK0.62539706
102ARAF0.61837332
103WNK30.60938437
104DYRK1A0.60389913
105MAP3K10.60017812
106CSNK1A1L0.59879119
107MAP3K60.58705884
108MARK20.57354794
109FER0.57336137
110PDK10.56613713
111TNK20.56163085
112PRKD10.55283710
113BMPR20.54222879
114ADRBK10.53650744
115PRKAA10.53159669
116CDK30.52424741
117* PRKACA0.50682267
118PRKD20.50492585
119TRIM280.50474848
120MAPK120.49676846
121CAMK2G0.49140550
122STK160.48586763
123ROCK10.47728539
124CAMK1D0.46338605
125PLK30.46232565
126PRKG10.45734234
127PDPK10.44934674
128STK30.44674885
129MAPK100.44612472
130HIPK20.44242722
131CSNK1D0.43403055
132CDK180.42913975
133YES10.42813712
134CDK150.42615464
135PRKCI0.41221485
136MKNK10.40841870
137MAPKAPK30.40174486
138PKN10.39721830
139CSNK1A10.39619506
140PRKCA0.38887878
141TIE10.38040903
142PRKCQ0.37638343
143TEC0.36869370
144PRKACB0.36744989
145TRPM70.36645835
146PRKAA20.35839313
147KIT0.33586810
148VRK10.33218183
149BRSK20.33183012

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.53514916
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.08130466
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.37434653
4Nicotine addiction_Homo sapiens_hsa050333.30803262
5Butanoate metabolism_Homo sapiens_hsa006502.84014211
6Olfactory transduction_Homo sapiens_hsa047402.73251182
7Circadian entrainment_Homo sapiens_hsa047132.68180465
8GABAergic synapse_Homo sapiens_hsa047272.56796396
9Synaptic vesicle cycle_Homo sapiens_hsa047212.55040398
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.54534802
11Morphine addiction_Homo sapiens_hsa050322.46110800
12Glutamatergic synapse_Homo sapiens_hsa047242.34720592
13Long-term potentiation_Homo sapiens_hsa047202.26372606
14Insulin secretion_Homo sapiens_hsa049112.23961031
15Vitamin B6 metabolism_Homo sapiens_hsa007502.19778797
16Amphetamine addiction_Homo sapiens_hsa050312.16308765
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.04806610
18* Cardiac muscle contraction_Homo sapiens_hsa042602.04687910
19Protein export_Homo sapiens_hsa030602.01812268
20Dopaminergic synapse_Homo sapiens_hsa047281.98076622
21* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.90855911
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.90415138
23* Dilated cardiomyopathy_Homo sapiens_hsa054141.87723742
24Salivary secretion_Homo sapiens_hsa049701.86690648
25Cholinergic synapse_Homo sapiens_hsa047251.85285638
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78413468
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77036752
28Calcium signaling pathway_Homo sapiens_hsa040201.76577902
29Taste transduction_Homo sapiens_hsa047421.75657099
30Renin secretion_Homo sapiens_hsa049241.75514246
31Propanoate metabolism_Homo sapiens_hsa006401.73872331
32* Oxytocin signaling pathway_Homo sapiens_hsa049211.65555331
33Serotonergic synapse_Homo sapiens_hsa047261.64913500
34Gastric acid secretion_Homo sapiens_hsa049711.55229064
35Type II diabetes mellitus_Homo sapiens_hsa049301.54800133
36* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.53241545
37Cocaine addiction_Homo sapiens_hsa050301.50456830
38Nitrogen metabolism_Homo sapiens_hsa009101.49584385
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49334245
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.46276850
41cAMP signaling pathway_Homo sapiens_hsa040241.40961747
42Ether lipid metabolism_Homo sapiens_hsa005651.35199795
43Long-term depression_Homo sapiens_hsa047301.31536697
44Linoleic acid metabolism_Homo sapiens_hsa005911.29135035
45GnRH signaling pathway_Homo sapiens_hsa049121.27107757
46Peroxisome_Homo sapiens_hsa041461.24771277
47Tryptophan metabolism_Homo sapiens_hsa003801.23448727
48Selenocompound metabolism_Homo sapiens_hsa004501.19708762
49* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.18863964
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17508367
51Circadian rhythm_Homo sapiens_hsa047101.14749300
52beta-Alanine metabolism_Homo sapiens_hsa004101.14124814
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13713770
54Vascular smooth muscle contraction_Homo sapiens_hsa042701.13539476
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12986308
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12186328
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08053633
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.06709472
59Gap junction_Homo sapiens_hsa045401.04495311
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04019792
61Folate biosynthesis_Homo sapiens_hsa007901.03697779
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01728794
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97260543
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91938961
65Fatty acid elongation_Homo sapiens_hsa000620.91865154
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91370277
67Collecting duct acid secretion_Homo sapiens_hsa049660.89420956
68Pancreatic secretion_Homo sapiens_hsa049720.88358223
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87764670
70Sulfur metabolism_Homo sapiens_hsa009200.87559503
71Regulation of autophagy_Homo sapiens_hsa041400.85639866
72Glucagon signaling pathway_Homo sapiens_hsa049220.85079687
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.84642306
74Sphingolipid metabolism_Homo sapiens_hsa006000.84240756
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83260190
76Mineral absorption_Homo sapiens_hsa049780.82517668
77Estrogen signaling pathway_Homo sapiens_hsa049150.82110900
78Fatty acid metabolism_Homo sapiens_hsa012120.80312341
79Fatty acid degradation_Homo sapiens_hsa000710.79965537
80Alzheimers disease_Homo sapiens_hsa050100.77935376
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76772785
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76629556
83Glioma_Homo sapiens_hsa052140.73477491
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72996246
85Melanogenesis_Homo sapiens_hsa049160.72824647
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72241157
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70114735
88ErbB signaling pathway_Homo sapiens_hsa040120.69725691
89ABC transporters_Homo sapiens_hsa020100.69666770
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.68433570
91Arachidonic acid metabolism_Homo sapiens_hsa005900.67922184
92Caffeine metabolism_Homo sapiens_hsa002320.66794846
93Dorso-ventral axis formation_Homo sapiens_hsa043200.66458727
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.65979955
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65697946
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65404386
97Inositol phosphate metabolism_Homo sapiens_hsa005620.65401609
98Axon guidance_Homo sapiens_hsa043600.64906140
99Chemical carcinogenesis_Homo sapiens_hsa052040.64243194
100Parkinsons disease_Homo sapiens_hsa050120.62190363
101Retinol metabolism_Homo sapiens_hsa008300.62086552
102Oxidative phosphorylation_Homo sapiens_hsa001900.61345326
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60929337
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60868873
105Thyroid hormone synthesis_Homo sapiens_hsa049180.60549430
106Vibrio cholerae infection_Homo sapiens_hsa051100.59797807
107Choline metabolism in cancer_Homo sapiens_hsa052310.59212003
108Ovarian steroidogenesis_Homo sapiens_hsa049130.59149250
109* MAPK signaling pathway_Homo sapiens_hsa040100.57739954
110RNA degradation_Homo sapiens_hsa030180.56096255
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54157084
112Metabolic pathways_Homo sapiens_hsa011000.53961420
113Oocyte meiosis_Homo sapiens_hsa041140.53520091
114mTOR signaling pathway_Homo sapiens_hsa041500.53199631
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52645253
116Histidine metabolism_Homo sapiens_hsa003400.52365837
117Basal transcription factors_Homo sapiens_hsa030220.52254550
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51515132
119Insulin signaling pathway_Homo sapiens_hsa049100.50105910
120Glycerolipid metabolism_Homo sapiens_hsa005610.49176240
121Ras signaling pathway_Homo sapiens_hsa040140.45426384
1222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44392143
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44338085
124Arginine biosynthesis_Homo sapiens_hsa002200.42935663
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42503672
126Rap1 signaling pathway_Homo sapiens_hsa040150.39635901
127VEGF signaling pathway_Homo sapiens_hsa043700.38930473
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37185714
129Huntingtons disease_Homo sapiens_hsa050160.35708576
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35367273
131Type I diabetes mellitus_Homo sapiens_hsa049400.35208451
132Alcoholism_Homo sapiens_hsa050340.31655437
133Wnt signaling pathway_Homo sapiens_hsa043100.31221790
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.30737206
135HIF-1 signaling pathway_Homo sapiens_hsa040660.30481357
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30176677
137AMPK signaling pathway_Homo sapiens_hsa041520.28955264
138Insulin resistance_Homo sapiens_hsa049310.26947238
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.25742548
140Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24600508
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.24081896
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23824284
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23807932
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23485336
145Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23396155
146Renal cell carcinoma_Homo sapiens_hsa052110.23246430
147Non-small cell lung cancer_Homo sapiens_hsa052230.23085210
148Endometrial cancer_Homo sapiens_hsa052130.22282802
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.22018630

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