CACTIN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.32566018
2mannose metabolic process (GO:0006013)5.21592660
3positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.82187813
4DNA unwinding involved in DNA replication (GO:0006268)4.70300521
5protein localization to kinetochore (GO:0034501)4.67688904
6formation of translation preinitiation complex (GO:0001731)4.27747130
7DNA replication initiation (GO:0006270)4.11543124
8positive thymic T cell selection (GO:0045059)4.06051458
9DNA strand elongation involved in DNA replication (GO:0006271)3.97720149
10folic acid-containing compound biosynthetic process (GO:0009396)3.89554010
11semaphorin-plexin signaling pathway (GO:0071526)3.85642885
12protein localization to chromosome, centromeric region (GO:0071459)3.85555390
13mitotic nuclear envelope disassembly (GO:0007077)3.84995861
14thymic T cell selection (GO:0045061)3.80007094
15viral transcription (GO:0019083)3.78869684
16negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.78365340
17DNA replication checkpoint (GO:0000076)3.76112184
18DNA strand elongation (GO:0022616)3.73584890
19heterochromatin organization (GO:0070828)3.71847009
20apoptotic process involved in morphogenesis (GO:0060561)3.69948781
21mitotic sister chromatid segregation (GO:0000070)3.68015641
22translational termination (GO:0006415)3.67819320
23response to muramyl dipeptide (GO:0032495)3.65109780
24positive regulation of histone deacetylation (GO:0031065)3.64377609
25membrane disassembly (GO:0030397)3.59332744
26nuclear envelope disassembly (GO:0051081)3.59332744
27DNA replication-dependent nucleosome organization (GO:0034723)3.54690788
28DNA replication-dependent nucleosome assembly (GO:0006335)3.54690788
29IMP biosynthetic process (GO:0006188)3.47409524
30maturation of SSU-rRNA (GO:0030490)3.45466645
31negative regulation of RNA splicing (GO:0033119)3.44267343
32regulation of translational fidelity (GO:0006450)3.43549840
33ribosomal small subunit biogenesis (GO:0042274)3.43045947
34telomere maintenance via semi-conservative replication (GO:0032201)3.42258216
35translational initiation (GO:0006413)3.41541479
36mitotic chromosome condensation (GO:0007076)3.41477696
37translational elongation (GO:0006414)3.40740760
38regulation of NFAT protein import into nucleus (GO:0051532)3.40120333
39DNA deamination (GO:0045006)3.39537777
40positive regulation of protein kinase C signaling (GO:0090037)3.38937846
41sister chromatid segregation (GO:0000819)3.38755244
42nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.37217981
43ribosomal small subunit assembly (GO:0000028)3.34737855
44negative regulation of cell size (GO:0045792)3.33617659
45cell-substrate adherens junction assembly (GO:0007045)3.32987792
46focal adhesion assembly (GO:0048041)3.32987792
47nuclear pore organization (GO:0006999)3.32705486
48adherens junction assembly (GO:0034333)3.32297651
49DNA duplex unwinding (GO:0032508)3.31233882
50ribosome biogenesis (GO:0042254)3.30018265
51modulation by virus of host process (GO:0019054)3.29486840
52UV protection (GO:0009650)3.27686138
53DNA geometric change (GO:0032392)3.26843262
54nuclear pore complex assembly (GO:0051292)3.26817866
55GDP-mannose metabolic process (GO:0019673)3.25201238
563-UTR-mediated mRNA stabilization (GO:0070935)3.25061068
57NIK/NF-kappaB signaling (GO:0038061)3.24776180
58CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.23824749
59regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.22438866
60regulation of translational termination (GO:0006449)3.21953902
61regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19057575
62negative regulation of mRNA processing (GO:0050686)3.17901048
63activation of Rac GTPase activity (GO:0032863)3.16613983
64dosage compensation (GO:0007549)3.15014773
65adenosine receptor signaling pathway (GO:0001973)3.12984261
66nucleobase biosynthetic process (GO:0046112)3.12535840
67ribonucleoprotein complex biogenesis (GO:0022613)3.10789889
68regulation of mammary gland epithelial cell proliferation (GO:0033599)3.10410053
69mitotic metaphase plate congression (GO:0007080)3.09200157
70modulation by symbiont of host cellular process (GO:0044068)3.08646701
71IMP metabolic process (GO:0046040)3.07978059
72maternal placenta development (GO:0001893)3.06559289
73planar cell polarity pathway involved in neural tube closure (GO:0090179)3.03297329
74folic acid metabolic process (GO:0046655)3.01396203
75pre-miRNA processing (GO:0031054)3.01076946
76nuclear envelope organization (GO:0006998)2.99272329
77positive regulation of protein deacetylation (GO:0090312)2.99106443
78cellular response to virus (GO:0098586)2.98303862
79mitotic G1 DNA damage checkpoint (GO:0031571)2.97068215
80peptidyl-arginine omega-N-methylation (GO:0035247)2.96734395
81activation of MAPKKK activity (GO:0000185)2.95787133
82regulation of spindle organization (GO:0090224)2.95343701
83negative regulation of histone methylation (GO:0031061)2.91261576
84negative regulation of mRNA metabolic process (GO:1903312)2.90042363
85chromatin assembly (GO:0031497)2.90036456
86viral life cycle (GO:0019058)2.89447229
87cellular protein complex disassembly (GO:0043624)2.89220190
88telomere maintenance via recombination (GO:0000722)2.88395675
89positive T cell selection (GO:0043368)2.88379019
90regulation of gene silencing by RNA (GO:0060966)2.87816908
91regulation of posttranscriptional gene silencing (GO:0060147)2.87816908
92regulation of gene silencing by miRNA (GO:0060964)2.87816908
93regulation of ARF GTPase activity (GO:0032312)2.87580167
94T cell selection (GO:0045058)2.87014398
95spliceosomal tri-snRNP complex assembly (GO:0000244)2.85846770
96mRNA stabilization (GO:0048255)2.85721499
97RNA stabilization (GO:0043489)2.85721499
98regulation of chromatin binding (GO:0035561)2.84575816
99protein complex disassembly (GO:0043241)2.84088065
100mitotic recombination (GO:0006312)2.83593226
101histone H4 deacetylation (GO:0070933)2.83093000
102regulation of histone H3-K9 methylation (GO:0051570)2.82746299
103SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.82550865
104proline biosynthetic process (GO:0006561)2.81386748
105protein insertion into membrane (GO:0051205)2.80850473
106activation of JUN kinase activity (GO:0007257)2.80726089
107regulation of interferon-beta biosynthetic process (GO:0045357)2.78927941
108positive regulation of CREB transcription factor activity (GO:0032793)2.78913265
109ribosome assembly (GO:0042255)2.78881323
110negative regulation of granulocyte differentiation (GO:0030853)2.77538656
111positive regulation of gamma-delta T cell activation (GO:0046645)2.74317406
112regulation of hippo signaling (GO:0035330)2.73648743
113protein targeting to ER (GO:0045047)2.73527804
114rRNA processing (GO:0006364)2.71328520
115positive regulation of chromosome segregation (GO:0051984)2.71188769
116histone H3-K36 demethylation (GO:0070544)2.71149865
117chromatin assembly or disassembly (GO:0006333)2.70552210
118antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.70250222
119* regulation of type I interferon-mediated signaling pathway (GO:0060338)2.69307140
120regulation of mitotic spindle organization (GO:0060236)2.69220879
121histone H3 deacetylation (GO:0070932)2.68660775
122cotranslational protein targeting to membrane (GO:0006613)2.68564089
123phosphatidylglycerol biosynthetic process (GO:0006655)2.68240607
124protein localization to chromosome (GO:0034502)2.68103753
125antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.67738743
126pentose-phosphate shunt (GO:0006098)2.67601287
127regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.67409652
128negative regulation of viral release from host cell (GO:1902187)2.66883841
129telomere maintenance via telomere lengthening (GO:0010833)2.64413524
130regulation of gamma-delta T cell differentiation (GO:0045586)2.64271404
131DNA conformation change (GO:0071103)2.64173849
132adenine nucleotide transport (GO:0051503)2.63690133
133trophectodermal cell differentiation (GO:0001829)2.63593059
134translesion synthesis (GO:0019985)2.63452850
135regulation of cytokine production involved in inflammatory response (GO:1900015)2.63328959
136rRNA metabolic process (GO:0016072)2.62748749
137nuclear-transcribed mRNA catabolic process (GO:0000956)2.62378359
138* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.61871102
139* mRNA splicing, via spliceosome (GO:0000398)2.61871102
140macromolecular complex disassembly (GO:0032984)2.61825249
141ribosomal large subunit biogenesis (GO:0042273)2.61318168
142regulation of early endosome to late endosome transport (GO:2000641)2.61108086
143atrioventricular valve morphogenesis (GO:0003181)2.60923994
144positive regulation of protein dephosphorylation (GO:0035307)2.60810883
145histone H3-K4 methylation (GO:0051568)2.60714529
146cell migration in hindbrain (GO:0021535)2.60071099
147regulation of monocyte differentiation (GO:0045655)2.59913991
148establishment of protein localization to endoplasmic reticulum (GO:0072599)2.59358546
149* RNA splicing, via transesterification reactions (GO:0000375)2.59331732
150spliceosomal snRNP assembly (GO:0000387)2.58784803
151positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.58547491
152regulation of glucose import in response to insulin stimulus (GO:2001273)2.58037500
153mitotic G1/S transition checkpoint (GO:0044819)2.57428381
154tolerance induction (GO:0002507)2.56417688
155natural killer cell differentiation (GO:0001779)2.56000261
156regulation of gamma-delta T cell activation (GO:0046643)2.55875071
157regulation of RNA export from nucleus (GO:0046831)2.54792830
158RNA catabolic process (GO:0006401)2.54763952
159regulation of protein heterodimerization activity (GO:0043497)2.53880499
160histone phosphorylation (GO:0016572)2.53108535
161intracellular estrogen receptor signaling pathway (GO:0030520)2.53056046
162metaphase plate congression (GO:0051310)2.52440053
163purine nucleobase biosynthetic process (GO:0009113)2.52079274
164modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.51435791
165modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.51435791
166positive regulation by organism of defense response of other organism involved in symbiotic interact2.51435791
167modulation by symbiont of host immune response (GO:0052553)2.51435791
168positive regulation by symbiont of host defense response (GO:0052509)2.51435791
169modulation by symbiont of host defense response (GO:0052031)2.51435791
170snRNA metabolic process (GO:0016073)2.51403652
171cell-substrate junction assembly (GO:0007044)2.50891986
172protein localization to endosome (GO:0036010)2.50785449
173negative regulation of cell killing (GO:0031342)2.50438138
174negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.50438138
175negative thymic T cell selection (GO:0045060)2.50217305
176cellular response to interleukin-4 (GO:0071353)2.49201984
177negative regulation of cAMP-mediated signaling (GO:0043951)2.48306677
178negative regulation of myotube differentiation (GO:0010832)2.47651807
179retrograde transport, endosome to Golgi (GO:0042147)2.42917194
180response to laminar fluid shear stress (GO:0034616)2.42835585
181osteoblast development (GO:0002076)2.41645864
182apoptotic process involved in development (GO:1902742)2.40711925
183positive regulation of protein homooligomerization (GO:0032464)2.37441525
184response to peptidoglycan (GO:0032494)2.37074678
185stress fiber assembly (GO:0043149)2.36463325
186germinal center formation (GO:0002467)2.36338359
187negative regulation of fatty acid transport (GO:2000192)2.36279719
188negative regulation of type 2 immune response (GO:0002829)2.36072260
189antigen processing and presentation of endogenous antigen (GO:0019883)2.34194358
190positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.34118929
191regulation of fatty acid beta-oxidation (GO:0031998)2.31774130
192granulocyte differentiation (GO:0030851)2.31168597
193endocytic recycling (GO:0032456)2.30333778
194leukocyte aggregation (GO:0070486)2.30243576

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.85971057
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.82784728
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.66557737
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.33638615
5MYC_22102868_ChIP-Seq_BL_Human3.07023094
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.54014324
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.52469137
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.52404272
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.49069055
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.47516602
11VDR_21846776_ChIP-Seq_THP-1_Human2.17409325
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.16810275
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.11516828
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.10922064
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.97649882
16XRN2_22483619_ChIP-Seq_HELA_Human1.96323788
17ETS1_20019798_ChIP-Seq_JURKAT_Human1.88723859
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85079741
19TP63_17297297_ChIP-ChIP_HaCaT_Human1.83730641
20CTCF_27219007_Chip-Seq_ERYTHROID_Human1.82740265
21TET1_21451524_ChIP-Seq_MESCs_Mouse1.81016864
22NELFA_20434984_ChIP-Seq_ESCs_Mouse1.74600816
23SA1_27219007_Chip-Seq_ERYTHROID_Human1.73156102
24KDM2B_26808549_Chip-Seq_K562_Human1.72628327
25CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.71742782
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71292843
27CIITA_25753668_ChIP-Seq_RAJI_Human1.67813181
28EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.65368495
29SMC4_20622854_ChIP-Seq_HELA_Human1.64351851
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.63404288
31BCOR_27268052_Chip-Seq_Bcells_Human1.63346636
32KDM2B_26808549_Chip-Seq_JURKAT_Human1.62947622
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.61165713
34BCL6_27268052_Chip-Seq_Bcells_Human1.56941121
35SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.56494999
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.56326848
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.56186757
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55952754
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.55932904
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55301565
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.55284480
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55072613
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54911912
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53399040
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.52830926
46AR_21909140_ChIP-Seq_LNCAP_Human1.50542747
47UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.48321521
48TCF7_22412390_ChIP-Seq_EML_Mouse1.48254293
49GABP_19822575_ChIP-Seq_HepG2_Human1.47537365
50DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47191061
51SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44391437
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.43497877
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43449394
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43273772
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42620334
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42010256
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41529398
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41487557
59PHF8_20622854_ChIP-Seq_HELA_Human1.39944362
60SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39377836
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39310458
62VDR_23849224_ChIP-Seq_CD4+_Human1.39252562
63CREB1_26743006_Chip-Seq_LNCaP_Human1.39201238
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39170837
65CTCF_27219007_Chip-Seq_Bcells_Human1.38330878
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38022597
67MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.37413073
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.36793738
69TP53_22127205_ChIP-Seq_IMR90_Human1.35981025
70E2F1_20622854_ChIP-Seq_HELA_Human1.34497621
71UTX_26944678_Chip-Seq_JUKART_Human1.33803216
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33754378
73CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.33729580
74KDM2B_26808549_Chip-Seq_DND41_Human1.33515883
75FOXP3_21729870_ChIP-Seq_TREG_Human1.32923984
76SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.32587739
77KDM5A_27292631_Chip-Seq_BREAST_Human1.32495476
78MAF_26560356_Chip-Seq_TH1_Human1.30671750
79RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29322242
80MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29288618
81KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28662476
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28004875
83TTF2_22483619_ChIP-Seq_HELA_Human1.26126732
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26057002
85RARB_24833708_ChIP-Seq_LIVER_Mouse1.25615167
86DCP1A_22483619_ChIP-Seq_HELA_Human1.25499684
87ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25276848
88SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25017002
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24519431
90RARA_24833708_ChIP-Seq_LIVER_Mouse1.23896458
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23445243
92SCL_19346495_ChIP-Seq_HPC-7_Human1.20151542
93THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19393985
94CTCF_21964334_ChIP-Seq_BJAB-B_Human1.19049803
95DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18713373
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18162096
97PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17767402
98CTCF_21964334_Chip-Seq_Bcells_Human1.17738262
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17538147
100MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17056869
101KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16859048
102ZNF263_19887448_ChIP-Seq_K562_Human1.16848277
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16472159
104CTCF_26484167_Chip-Seq_Bcells_Mouse1.16230551
105KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.16103576
106TFEB_21752829_ChIP-Seq_HELA_Human1.14477676
107CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14040196
108P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13313790
109SA1_27219007_Chip-Seq_Bcells_Human1.12523571
110LXR_22292898_ChIP-Seq_THP-1_Human1.12255183
111ATF3_27146783_Chip-Seq_COLON_Human1.12143297
112ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12058315
113ETS1_21867929_ChIP-Seq_TH2_Mouse1.11208714
114RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11176792
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09933850
116CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.09565739
117MAF_26560356_Chip-Seq_TH2_Human1.07491243
118FOXP1_21924763_ChIP-Seq_HESCs_Human1.07338784
119YY1_21170310_ChIP-Seq_MESCs_Mouse1.07233105
120GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07026394
121GATA1_19941827_ChIP-Seq_MEL_Mouse1.06838347
122SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06784583
123TP63_22573176_ChIP-Seq_HFKS_Human1.06451269
124CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06227641
125NCOR1_26117541_ChIP-Seq_K562_Human1.05425375
126MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05323111
127TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.05273047
128TP63_19390658_ChIP-ChIP_HaCaT_Human1.05266588
129ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04855338
130VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04193818
131SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03798337
132KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03705350
133TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02139560
134NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01756093
135FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01239675
136PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00781465
137RACK7_27058665_Chip-Seq_MCF-7_Human0.99695489
138GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98399518
139NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98180430
140KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98177881
141TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97663202
142TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97622025
143ELF1_20517297_ChIP-Seq_JURKAT_Human0.97470330
144E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97329587
145NANOG_21062744_ChIP-ChIP_HESCs_Human0.96562802
146VDR_24763502_ChIP-Seq_THP-1_Human0.96496557
147E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96329089
148RUNX1_22412390_ChIP-Seq_EML_Mouse0.95012751
149BRD4_27068464_Chip-Seq_AML-cells_Mouse0.95012470
150NOTCH1_21737748_ChIP-Seq_TLL_Human0.94800625
151TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94697047
152KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93752357
153MYB_26560356_Chip-Seq_TH1_Human0.93315749
154STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92623269
155KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.92554841
156KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.92554841
157KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.92554841
158P68_20966046_ChIP-Seq_HELA_Human0.92251352
159OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92013280

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.97542637
2MP0003111_abnormal_nucleus_morphology3.46423048
3MP0004957_abnormal_blastocyst_morpholog3.37092360
4MP0010352_gastrointestinal_tract_polyps3.08819696
5MP0003077_abnormal_cell_cycle3.03639414
6MP0010094_abnormal_chromosome_stability2.98594784
7MP0008057_abnormal_DNA_replication2.87587333
8MP0003705_abnormal_hypodermis_morpholog2.84177081
9MP0002396_abnormal_hematopoietic_system2.78290356
10MP0005058_abnormal_lysosome_morphology2.58794791
11MP0001730_embryonic_growth_arrest2.26396603
12MP0003453_abnormal_keratinocyte_physiol2.25305896
13MP0005451_abnormal_body_composition2.18652141
14MP0000350_abnormal_cell_proliferation2.14053456
15MP0005076_abnormal_cell_differentiation2.10499424
16MP0000751_myopathy2.09758129
17MP0004381_abnormal_hair_follicle2.03904964
18MP0003172_abnormal_lysosome_physiology2.03644675
19MP0008007_abnormal_cellular_replicative1.97406255
20MP0005171_absent_coat_pigmentation1.96232894
21MP0004858_abnormal_nervous_system1.94314938
22MP0002254_reproductive_system_inflammat1.94078735
23MP0000490_abnormal_crypts_of1.93377149
24MP0005409_darkened_coat_color1.83923408
25MP0004808_abnormal_hematopoietic_stem1.83705756
26MP0010307_abnormal_tumor_latency1.83385102
27MP0009278_abnormal_bone_marrow1.75150779
28MP0001672_abnormal_embryogenesis/_devel1.72965339
29MP0005380_embryogenesis_phenotype1.72965339
30MP0003984_embryonic_growth_retardation1.66596195
31MP0001545_abnormal_hematopoietic_system1.66172101
32MP0005397_hematopoietic_system_phenotyp1.66172101
33MP0001697_abnormal_embryo_size1.64601360
34MP0001986_abnormal_taste_sensitivity1.63981406
35MP0002088_abnormal_embryonic_growth/wei1.63499384
36MP0004130_abnormal_muscle_cell1.63401079
37MP0008058_abnormal_DNA_repair1.61037288
38MP0008932_abnormal_embryonic_tissue1.61019063
39MP0002080_prenatal_lethality1.60474750
40MP0002086_abnormal_extraembryonic_tissu1.57987544
41MP0009333_abnormal_splenocyte_physiolog1.57741180
42MP0004197_abnormal_fetal_growth/weight/1.57180173
43MP0006054_spinal_hemorrhage1.53531097
44MP0002085_abnormal_embryonic_tissue1.53506693
45MP0003763_abnormal_thymus_physiology1.52343458
46MP0000685_abnormal_immune_system1.50474123
47MP0003566_abnormal_cell_adhesion1.49852805
48MP0000678_abnormal_parathyroid_gland1.49474582
49MP0000003_abnormal_adipose_tissue1.49062717
50MP0002249_abnormal_larynx_morphology1.48982098
51MP0005023_abnormal_wound_healing1.48092305
52MP0005174_abnormal_tail_pigmentation1.47896412
53MP0002084_abnormal_developmental_patter1.46590195
54MP0002019_abnormal_tumor_incidence1.45608639
55MP0010030_abnormal_orbit_morphology1.45588886
56MP0001661_extended_life_span1.44952893
57MP0000703_abnormal_thymus_morphology1.41646615
58MP0003123_paternal_imprinting1.41293858
59MP0005083_abnormal_biliary_tract1.41009664
60MP0002398_abnormal_bone_marrow1.40461332
61MP0005666_abnormal_adipose_tissue1.38269955
62MP0002653_abnormal_ependyma_morphology1.37140764
63MP0000313_abnormal_cell_death1.36728659
64MP0002722_abnormal_immune_system1.33317012
65MP0001849_ear_inflammation1.32962474
66MP0005375_adipose_tissue_phenotype1.32062020
67MP0000689_abnormal_spleen_morphology1.26609130
68MP0003279_aneurysm1.24016016
69MP0005000_abnormal_immune_tolerance1.19693051
70MP0003786_premature_aging1.19519541
71MP0000015_abnormal_ear_pigmentation1.19064453
72MP0003303_peritoneal_inflammation1.18529611
73MP0002723_abnormal_immune_serum1.18198507
74MP0001790_abnormal_immune_system1.17099299
75MP0005387_immune_system_phenotype1.17099299
76MP0000858_altered_metastatic_potential1.12622851
77MP0000747_muscle_weakness1.11661931
78MP0005423_abnormal_somatic_nervous1.11549566
79MP0002877_abnormal_melanocyte_morpholog1.09544191
80MP0002933_joint_inflammation1.08867577
81MP0004510_myositis1.08446225
82MP0002429_abnormal_blood_cell1.08377013
83MP0005025_abnormal_response_to1.06226445
84MP0002089_abnormal_postnatal_growth/wei1.05760876
85MP0000733_abnormal_muscle_development1.04921042
86MP0008260_abnormal_autophagy1.03713303
87MP0000759_abnormal_skeletal_muscle1.03634991
88MP0009931_abnormal_skin_appearance1.03464676
89MP0003567_abnormal_fetal_cardiomyocyte1.03052893
90MP0003119_abnormal_digestive_system0.98732091
91MP0004233_abnormal_muscle_weight0.96919554
92MP0000716_abnormal_immune_system0.96643121
93MP0002419_abnormal_innate_immunity0.96156867
94MP0008770_decreased_survivor_rate0.95737596
95MP0000013_abnormal_adipose_tissue0.94880758
96MP0009840_abnormal_foam_cell0.94701164
97MP0002998_abnormal_bone_remodeling0.93503077
98MP0001915_intracranial_hemorrhage0.93271637
99MP0000477_abnormal_intestine_morphology0.92993039
100MP0001800_abnormal_humoral_immune0.92911948
101MP0002405_respiratory_system_inflammati0.91766681
102MP0000358_abnormal_cell_content/0.90248343
103MP0001835_abnormal_antigen_presentation0.90206407
104MP0005310_abnormal_salivary_gland0.88665933
105MP0008961_abnormal_basal_metabolism0.87593622
106MP0003300_gastrointestinal_ulcer0.86633006
107MP0005621_abnormal_cell_physiology0.86368951
108MP0010234_abnormal_vibrissa_follicle0.85648382
109MP0004264_abnormal_extraembryonic_tissu0.85530641
110MP0008438_abnormal_cutaneous_collagen0.85317684
111MP0001293_anophthalmia0.85064093
112MP0000767_abnormal_smooth_muscle0.85024524
113MP0002925_abnormal_cardiovascular_devel0.84926735
114MP0000465_gastrointestinal_hemorrhage0.84593245
115MP0003436_decreased_susceptibility_to0.84480788
116MP0003329_amyloid_beta_deposits0.83981381
117MP0002092_abnormal_eye_morphology0.83378456
118MP0001502_abnormal_circadian_rhythm0.81896152
119MP0005501_abnormal_skin_physiology0.80297284
120MP0003656_abnormal_erythrocyte_physiolo0.80064358
121MP0005384_cellular_phenotype0.79955462
122MP0000428_abnormal_craniofacial_morphol0.79420334
123MP0003136_yellow_coat_color0.79261017
124MP0003221_abnormal_cardiomyocyte_apopto0.78922501
125MP0000750_abnormal_muscle_regeneration0.78323974
126MP0004087_abnormal_muscle_fiber0.78215622
127MP0003646_muscle_fatigue0.77289020
128MP0000470_abnormal_stomach_morphology0.76414288
129MP0003115_abnormal_respiratory_system0.75034953
130MP0001958_emphysema0.74574717
131MP0000537_abnormal_urethra_morphology0.74471889
132MP0002420_abnormal_adaptive_immunity0.73916878
133MP0001533_abnormal_skeleton_physiology0.73700847
134MP0010155_abnormal_intestine_physiology0.73380278
135MP0001819_abnormal_immune_cell0.72408077
136MP0002452_abnormal_antigen_presenting0.72408042
137MP0009053_abnormal_anal_canal0.72390029
138MP0002111_abnormal_tail_morphology0.71829049
139MP0003448_altered_tumor_morphology0.71491591
140MP0003091_abnormal_cell_migration0.71326994
141MP0002060_abnormal_skin_morphology0.71152992
142MP0004947_skin_inflammation0.70797637
143MP0001873_stomach_inflammation0.70661624
144MP0000266_abnormal_heart_morphology0.70610595
145MP0003806_abnormal_nucleotide_metabolis0.69968957
146MP0002269_muscular_atrophy0.69668141
147MP0002970_abnormal_white_adipose0.69649689
148MP0009672_abnormal_birth_weight0.68649389
149MP0004185_abnormal_adipocyte_glucose0.68293437
150MP0002932_abnormal_joint_morphology0.66982262
151MP0010630_abnormal_cardiac_muscle0.66812465
152MP0001348_abnormal_lacrimal_gland0.66446532

Predicted human phenotypes

RankGene SetZ-score
1Thin bony cortex (HP:0002753)3.81578294
2Annular pancreas (HP:0001734)3.62825584
3Hemorrhage of the eye (HP:0011885)3.48355753
4Ependymoma (HP:0002888)3.36899360
5Testicular atrophy (HP:0000029)3.34863845
6Multiple enchondromatosis (HP:0005701)3.33452828
7Turricephaly (HP:0000262)3.26936129
8Selective tooth agenesis (HP:0001592)3.21977961
9Protrusio acetabuli (HP:0003179)3.21738697
10Hyperacusis (HP:0010780)3.05796754
11Abnormality of cells of the erythroid lineage (HP:0012130)3.03775129
12Cerebral aneurysm (HP:0004944)3.03259687
13Abnormal number of erythroid precursors (HP:0012131)2.93581639
14Basal cell carcinoma (HP:0002671)2.89827703
15Abnormality of the fingertips (HP:0001211)2.85338090
16Intestinal fistula (HP:0100819)2.82044142
17Obstructive sleep apnea (HP:0002870)2.81105508
18Broad face (HP:0000283)2.81045531
19Reticulocytopenia (HP:0001896)2.77010438
20Birth length less than 3rd percentile (HP:0003561)2.72981888
21Broad distal phalanx of finger (HP:0009836)2.69944784
22Trismus (HP:0000211)2.61472330
23Myopathic facies (HP:0002058)2.57756228
24Ulnar bowing (HP:0003031)2.52605115
25Joint stiffness (HP:0001387)2.49902413
26Mesangial abnormality (HP:0001966)2.47909381
27Ankle contracture (HP:0006466)2.47046711
28Disproportionate tall stature (HP:0001519)2.44038930
29Rectal prolapse (HP:0002035)2.42803804
30Patellar aplasia (HP:0006443)2.41932736
31Abnormality of the lower motor neuron (HP:0002366)2.41210611
32Breast hypoplasia (HP:0003187)2.40569645
33Microretrognathia (HP:0000308)2.38594189
34Genu recurvatum (HP:0002816)2.37917666
35Stridor (HP:0010307)2.36987852
36Easy fatigability (HP:0003388)2.35436075
37Medulloblastoma (HP:0002885)2.34410681
38Thrombocytosis (HP:0001894)2.33812731
39Thin ribs (HP:0000883)2.33355030
40Long palpebral fissure (HP:0000637)2.32796584
41Hand muscle atrophy (HP:0009130)2.31295558
42Increased density of long bones (HP:0006392)2.28087320
43Abnormality of the astrocytes (HP:0100707)2.27162992
44Astrocytoma (HP:0009592)2.27162992
45Aplasia/Hypoplasia of the patella (HP:0006498)2.26933583
46Colon cancer (HP:0003003)2.25886807
47Abnormality of the heme biosynthetic pathway (HP:0010472)2.25659335
48Distal lower limb amyotrophy (HP:0008944)2.24458038
49High pitched voice (HP:0001620)2.20825512
50Colitis (HP:0002583)2.20332188
51Upper limb amyotrophy (HP:0009129)2.17933461
52Distal upper limb amyotrophy (HP:0007149)2.17933461
53Emphysema (HP:0002097)2.17677577
54Pointed chin (HP:0000307)2.17488879
55Rib fusion (HP:0000902)2.15578728
56Vaginal fistula (HP:0004320)2.15248066
57Squamous cell carcinoma (HP:0002860)2.14545112
58Dislocated radial head (HP:0003083)2.13392444
59Premature rupture of membranes (HP:0001788)2.12435772
60Biconcave vertebral bodies (HP:0004586)2.10526742
61Angiofibromas (HP:0010615)2.08710039
62Adenoma sebaceum (HP:0009720)2.08710039
63Rectal fistula (HP:0100590)2.07964967
64Rectovaginal fistula (HP:0000143)2.07964967
65Eczematoid dermatitis (HP:0000976)2.07804466
66Skin tags (HP:0010609)2.07180157
67Neoplasm of striated muscle (HP:0009728)2.06321228
68Supernumerary nipples (HP:0002558)2.05123227
69Proximal placement of thumb (HP:0009623)2.04754019
70Abnormality of the radial head (HP:0003995)2.04424346
71Progressive muscle weakness (HP:0003323)2.04138276
72Deviation of the thumb (HP:0009603)2.02756980
73Prominent nose (HP:0000448)2.02063976
74Broad palm (HP:0001169)2.01834202
75Increased nuchal translucency (HP:0010880)2.01822181
76Renal duplication (HP:0000075)2.01674131
77Rhabdomyosarcoma (HP:0002859)2.01587280
78Nasal polyposis (HP:0100582)2.01462213
79Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.00237202
80Preauricular skin tag (HP:0000384)1.99278484
81Slender long bone (HP:0003100)1.98061397
82Atresia of the external auditory canal (HP:0000413)1.95196190
83Achilles tendon contracture (HP:0001771)1.94753920
84Abnormality of reticulocytes (HP:0004312)1.94292698
85Pallor (HP:0000980)1.94195844
86Increased variability in muscle fiber diameter (HP:0003557)1.93572128
87Short 4th metacarpal (HP:0010044)1.92004314
88Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.92004314
89Abnormality of the anterior horn cell (HP:0006802)1.91982875
90Degeneration of anterior horn cells (HP:0002398)1.91982875
91Missing ribs (HP:0000921)1.91833909
92Difficulty climbing stairs (HP:0003551)1.91690672
93Shallow orbits (HP:0000586)1.89533088
94Dysmetric saccades (HP:0000641)1.88599799
95Abnormality of the nasal mucosa (HP:0000433)1.88325278
96Insomnia (HP:0100785)1.87294835
97Dysostosis multiplex (HP:0000943)1.86417259
98Cellulitis (HP:0100658)1.85659487
99Progressive external ophthalmoplegia (HP:0000590)1.85007951
100Overlapping toe (HP:0001845)1.84960263
101Cervical subluxation (HP:0003308)1.84433626
102Germ cell neoplasia (HP:0100728)1.83913171
103Increased connective tissue (HP:0009025)1.83860921
104Increased neuronal autofluorescent lipopigment (HP:0002074)1.83403935
105Myelodysplasia (HP:0002863)1.82828088
106Absent thumb (HP:0009777)1.82732605
107Gastrointestinal inflammation (HP:0004386)1.82718083
108Congenital hip dislocation (HP:0001374)1.82234736
109Increased cerebral lipofuscin (HP:0011813)1.81709310
110Abnormality of the thoracic spine (HP:0100711)1.80722058
111Abnormality of mucopolysaccharide metabolism (HP:0011020)1.80467193
112Abnormality of polysaccharide metabolism (HP:0011012)1.80467193
113Abnormality of glycosaminoglycan metabolism (HP:0004371)1.80467193
114Hypertensive crisis (HP:0100735)1.80415907
115Gastrointestinal infarctions (HP:0005244)1.80308449
116Carpal bone hypoplasia (HP:0001498)1.80138036
117Delayed epiphyseal ossification (HP:0002663)1.79032300
118Cafe-au-lait spot (HP:0000957)1.79017303
119Neoplasm of the pancreas (HP:0002894)1.77622456
120Neoplasm of the oral cavity (HP:0100649)1.77606784
121Cutaneous melanoma (HP:0012056)1.77074683
122Long eyelashes (HP:0000527)1.76717106
123Premature skin wrinkling (HP:0100678)1.76707924
124Sparse lateral eyebrow (HP:0005338)1.75489250
125Aplastic anemia (HP:0001915)1.75128696
126Abnormal number of incisors (HP:0011064)1.74645852
127Mitral regurgitation (HP:0001653)1.74360182
128Bladder diverticulum (HP:0000015)1.74141084
129Peritonitis (HP:0002586)1.72464262
130Bowing of the arm (HP:0006488)1.72028661
131Bowed forearm bones (HP:0003956)1.72028661
132Macrocytic anemia (HP:0001972)1.71557672
133Abnormality of the calcaneus (HP:0008364)1.71502958
134Abnormality of the Achilles tendon (HP:0005109)1.70233695
135Short 5th finger (HP:0009237)1.70063513
136Blue sclerae (HP:0000592)1.69689816
137Spina bifida occulta (HP:0003298)1.69454584
138Mucopolysacchariduria (HP:0008155)1.69314426
139Urinary glycosaminoglycan excretion (HP:0003541)1.69314426
140Bowel diverticulosis (HP:0005222)1.69093151
141Deep palmar crease (HP:0006191)1.68168946
142Spinal cord lesions (HP:0100561)1.68126523
143Syringomyelia (HP:0003396)1.68126523
144IgM deficiency (HP:0002850)1.68008159
145Coronal craniosynostosis (HP:0004440)1.67526938
146Facial hemangioma (HP:0000329)1.67036570
147Abnormality of the peritoneum (HP:0002585)1.66858055
148Increased IgE level (HP:0003212)1.66358196
149Pustule (HP:0200039)1.66304603
150Hypertriglyceridemia (HP:0002155)1.65183640
151Abnormality of skeletal muscle fiber size (HP:0012084)1.65052961
152Polycythemia (HP:0001901)1.64481664
153Aplasia/hypoplasia of the humerus (HP:0006507)1.64146199
154Radial bowing (HP:0002986)1.63759386
155Truncus arteriosus (HP:0001660)1.63530280
156Round ear (HP:0100830)1.61272207
157Poikiloderma (HP:0001029)1.61187646
158Anteriorly placed anus (HP:0001545)1.61141407
159Persistence of primary teeth (HP:0006335)1.60785958
160Increased serum ferritin (HP:0003281)1.60711575
161Patellar dislocation (HP:0002999)1.59698885
162Amaurosis fugax (HP:0100576)1.59543939
163Atrophy/Degeneration involving motor neurons (HP:0007373)1.59477125
164Spinal rigidity (HP:0003306)1.59452706
165Glioma (HP:0009733)1.59408964
166Ragged-red muscle fibers (HP:0003200)1.58579931
167Centrally nucleated skeletal muscle fibers (HP:0003687)1.58214355
168Flared metaphyses (HP:0003015)1.58024539
169External ophthalmoplegia (HP:0000544)1.57258349
170Flattened epiphyses (HP:0003071)1.57196836
171Exercise-induced myalgia (HP:0003738)1.57181407
172Abnormality of T cells (HP:0002843)1.56847355
173Glossoptosis (HP:0000162)1.56705356
174Dilatation of the ascending aorta (HP:0005111)1.55858163

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K104.23729506
2EEF2K3.59729047
3PRPF4B3.40020707
4SMG13.30569098
5TRIB33.21976347
6CDK123.04318425
7CDC72.83239644
8NEK22.59343289
9PKN22.58120355
10BUB12.58005576
11ERN12.49814873
12WEE12.38582650
13IRAK32.28538034
14STK102.11024236
15MAP4K12.05885782
16MAP3K131.85048381
17DYRK31.82923863
18GRK61.80104535
19NME21.75154043
20MAPK151.70200990
21RPS6KB21.67570458
22SCYL21.65715374
23CDK41.64657543
24LRRK21.61813124
25TTK1.54785962
26PAK41.53941554
27CDK71.48486704
28TESK21.47249216
29ICK1.42782773
30MARK21.41579256
31MAP3K81.39873469
32RPS6KA41.36347569
33TTN1.28588201
34PLK11.28527721
35NEK11.23098529
36IRAK41.20765580
37TNK21.20135893
38PRKD31.17395844
39RPS6KA21.13881682
40CDC42BPA1.12770688
41IRAK21.12711401
42TBK11.11751587
43KDR1.09941373
44TAOK21.08369599
45AURKB1.07578396
46ALK1.07453949
47RPS6KL11.06683326
48RPS6KC11.06683326
49MAPKAPK31.06332731
50EPHA21.05465257
51MTOR1.03936109
52MAP2K31.02449709
53CHEK21.01654952
54PIM21.01399776
55TAOK11.01389610
56FLT30.99978573
57PDPK10.99366392
58CSF1R0.98823599
59ATR0.98695620
60RIPK40.97950589
61PIM10.97851981
62PDGFRA0.95531236
63ACVR1B0.95329773
64TGFBR10.95068287
65MAP3K140.94070372
66RPS6KA60.93950652
67EIF2AK10.93654715
68CHEK10.93540484
69PASK0.93358408
70JAK30.89338618
71SIK20.88531522
72MAP3K110.87963644
73LATS20.85390527
74ARAF0.85198728
75BRSK20.84198606
76AURKA0.83058335
77MAP3K10.83042848
78MAPK120.81961777
79BMX0.81879450
80PTK60.81511845
81ZAP700.81226208
82SRPK10.80952563
83TYRO30.80905489
84PAK20.79951565
85KSR20.79028451
86TLK10.78906414
87WNK40.76851201
88TSSK60.74894179
89RIPK10.71761405
90CDK20.69669924
91CDK60.67647980
92BRSK10.67176170
93PAK10.67154738
94STK40.65146590
95BTK0.64658151
96CDK190.63865899
97EPHB10.62621827
98TGFBR20.62488427
99IKBKB0.62279567
100SIK30.61784964
101PDK10.61076875
102BRAF0.60215911
103DYRK1B0.59723171
104AKT20.58105698
105SIK10.58030999
106CAMKK10.57829152
107ILK0.56577231
108TYK20.53837760
109MOS0.52691517
110MAP3K70.52391863
111HCK0.51946704
112MAPK110.51192490
113ATM0.50111697
114DDR20.49224600
115MAP2K20.49111196
116IKBKE0.47286247
117BLK0.46570555
118CAMK1D0.43640928
119PRKCH0.42641384
120MATK0.42611476
121NTRK10.42576287
122MAP2K60.42225365
123CSK0.42164808
124CHUK0.41278880
125PRKD20.37635777
126MAP3K60.37383005
127MAP3K30.37334999
128FGFR40.37136010
129RPS6KA10.36901720
130PTK20.36709051
131FES0.36392912
132PRKCI0.36171597
133RAF10.36062665
134CDK10.35784391
135KIT0.35138570
136BCKDK0.33648660
137MAPK70.33452687
138MARK30.33176338
139TRPM70.32531643
140HIPK20.32421548
141TESK10.31662005
142MST1R0.31000551
143STK30.30952768
144CSNK2A20.30702335
145ITK0.30672289
146MAPK80.30257885
147STK110.30130368

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.27984144
2Mismatch repair_Homo sapiens_hsa034303.19413569
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97730726
4Spliceosome_Homo sapiens_hsa030402.97281930
5Other glycan degradation_Homo sapiens_hsa005112.93845677
6Ribosome_Homo sapiens_hsa030102.84918695
7Base excision repair_Homo sapiens_hsa034102.80447896
8RNA transport_Homo sapiens_hsa030132.79325691
9Cell cycle_Homo sapiens_hsa041102.54445123
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.44525409
11One carbon pool by folate_Homo sapiens_hsa006702.33005930
12Nucleotide excision repair_Homo sapiens_hsa034202.00904276
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.97615239
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.93203996
15Homologous recombination_Homo sapiens_hsa034401.89028184
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.88370634
17RNA polymerase_Homo sapiens_hsa030201.78983168
18p53 signaling pathway_Homo sapiens_hsa041151.74621044
19mRNA surveillance pathway_Homo sapiens_hsa030151.71416672
20Pyrimidine metabolism_Homo sapiens_hsa002401.61738946
21Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.59160167
22Proteasome_Homo sapiens_hsa030501.38615897
23Chronic myeloid leukemia_Homo sapiens_hsa052201.37304787
24Sulfur relay system_Homo sapiens_hsa041221.36694004
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34994044
26Small cell lung cancer_Homo sapiens_hsa052221.28675325
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.27942512
28Antigen processing and presentation_Homo sapiens_hsa046121.27824546
29Viral carcinogenesis_Homo sapiens_hsa052031.27229311
30Inositol phosphate metabolism_Homo sapiens_hsa005621.25047656
31Primary immunodeficiency_Homo sapiens_hsa053401.24877243
32TNF signaling pathway_Homo sapiens_hsa046681.22985197
33RNA degradation_Homo sapiens_hsa030181.21959878
34HTLV-I infection_Homo sapiens_hsa051661.21294261
35Bladder cancer_Homo sapiens_hsa052191.19655991
36Notch signaling pathway_Homo sapiens_hsa043301.18474398
37Pentose phosphate pathway_Homo sapiens_hsa000301.15989272
38Epstein-Barr virus infection_Homo sapiens_hsa051691.14536729
39Fanconi anemia pathway_Homo sapiens_hsa034601.13301023
40Thyroid cancer_Homo sapiens_hsa052161.12815488
41Non-homologous end-joining_Homo sapiens_hsa034501.12125369
42Biosynthesis of amino acids_Homo sapiens_hsa012301.11895668
43MicroRNAs in cancer_Homo sapiens_hsa052061.11541063
44Acute myeloid leukemia_Homo sapiens_hsa052211.09894443
45Phospholipase D signaling pathway_Homo sapiens_hsa040721.09167093
46Herpes simplex infection_Homo sapiens_hsa051681.06805508
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05638769
48GnRH signaling pathway_Homo sapiens_hsa049121.02003552
49mTOR signaling pathway_Homo sapiens_hsa041501.01482358
50Apoptosis_Homo sapiens_hsa042101.00600136
51Glioma_Homo sapiens_hsa052140.99382172
52B cell receptor signaling pathway_Homo sapiens_hsa046620.95844580
53Insulin signaling pathway_Homo sapiens_hsa049100.94780619
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.92857372
55Hepatitis C_Homo sapiens_hsa051600.91579352
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91108998
57ErbB signaling pathway_Homo sapiens_hsa040120.90818477
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90758217
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89181902
60Selenocompound metabolism_Homo sapiens_hsa004500.88908829
61Renal cell carcinoma_Homo sapiens_hsa052110.88121193
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.88095190
63Influenza A_Homo sapiens_hsa051640.86583338
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.86342908
65Colorectal cancer_Homo sapiens_hsa052100.84698106
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84489659
67Prolactin signaling pathway_Homo sapiens_hsa049170.84238716
68Lysosome_Homo sapiens_hsa041420.82543116
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82214479
70Shigellosis_Homo sapiens_hsa051310.81786687
71Systemic lupus erythematosus_Homo sapiens_hsa053220.81727288
72Lysine degradation_Homo sapiens_hsa003100.81632856
73Choline metabolism in cancer_Homo sapiens_hsa052310.80845631
74Non-small cell lung cancer_Homo sapiens_hsa052230.80186554
75MAPK signaling pathway_Homo sapiens_hsa040100.80104673
76Insulin resistance_Homo sapiens_hsa049310.79732269
77VEGF signaling pathway_Homo sapiens_hsa043700.77749127
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77581658
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77134367
80Prostate cancer_Homo sapiens_hsa052150.76535026
81Endocytosis_Homo sapiens_hsa041440.76283089
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74382099
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.73563380
84Hepatitis B_Homo sapiens_hsa051610.73442209
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72983018
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.72540363
87Pancreatic cancer_Homo sapiens_hsa052120.72255182
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71641367
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71297716
90Vitamin B6 metabolism_Homo sapiens_hsa007500.70996398
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70794593
92Estrogen signaling pathway_Homo sapiens_hsa049150.70608183
93Chemokine signaling pathway_Homo sapiens_hsa040620.69011981
94Proteoglycans in cancer_Homo sapiens_hsa052050.68951659
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.68784919
96Folate biosynthesis_Homo sapiens_hsa007900.68459457
97Hippo signaling pathway_Homo sapiens_hsa043900.68301631
98Oocyte meiosis_Homo sapiens_hsa041140.68170100
99Prion diseases_Homo sapiens_hsa050200.67550141
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65987352
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65741515
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.64949995
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64920955
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64734722
105FoxO signaling pathway_Homo sapiens_hsa040680.64317151
106Basal cell carcinoma_Homo sapiens_hsa052170.64044427
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63184429
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62607495
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.60368219
110Viral myocarditis_Homo sapiens_hsa054160.59331358
111T cell receptor signaling pathway_Homo sapiens_hsa046600.59306382
112Purine metabolism_Homo sapiens_hsa002300.58061568
113Measles_Homo sapiens_hsa051620.57819188
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.57708883
115Basal transcription factors_Homo sapiens_hsa030220.57148442
116Tuberculosis_Homo sapiens_hsa051520.56904177
117Pathways in cancer_Homo sapiens_hsa052000.56553834
118Adherens junction_Homo sapiens_hsa045200.56134017
119Carbon metabolism_Homo sapiens_hsa012000.55483125
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55424574
121Dorso-ventral axis formation_Homo sapiens_hsa043200.55270536
122HIF-1 signaling pathway_Homo sapiens_hsa040660.55055985
123Legionellosis_Homo sapiens_hsa051340.54534695
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.54151771
125Fructose and mannose metabolism_Homo sapiens_hsa000510.52227725
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50101129
127Melanogenesis_Homo sapiens_hsa049160.49717404
128Galactose metabolism_Homo sapiens_hsa000520.48365210
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47958457
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47846533
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46961559
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45585175
133TGF-beta signaling pathway_Homo sapiens_hsa043500.45560104
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45233543
135Focal adhesion_Homo sapiens_hsa045100.45185652
136Leishmaniasis_Homo sapiens_hsa051400.43942816
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43345143
138Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42575182
139Toxoplasmosis_Homo sapiens_hsa051450.41780164
140Endometrial cancer_Homo sapiens_hsa052130.40742463
141Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40713952
142AMPK signaling pathway_Homo sapiens_hsa041520.39767942
143Jak-STAT signaling pathway_Homo sapiens_hsa046300.39373922
144Platelet activation_Homo sapiens_hsa046110.35948855
145Osteoclast differentiation_Homo sapiens_hsa043800.35328517

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