CACUL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)5.13630708
2response to pheromone (GO:0019236)4.50252852
3alpha-linolenic acid metabolic process (GO:0036109)4.15824055
4cell wall macromolecule catabolic process (GO:0016998)4.04524955
5negative regulation of DNA-dependent DNA replication (GO:2000104)3.96663523
6lactate metabolic process (GO:0006089)3.94983168
7regulation of glucokinase activity (GO:0033131)3.91029241
8regulation of hexokinase activity (GO:1903299)3.91029241
9urea cycle (GO:0000050)3.90034556
10urea metabolic process (GO:0019627)3.90034556
11nuclear pore complex assembly (GO:0051292)3.79251263
12dicarboxylic acid biosynthetic process (GO:0043650)3.76462294
13negative regulation of fibrinolysis (GO:0051918)3.74115451
14low-density lipoprotein particle clearance (GO:0034383)3.61595750
15cell wall macromolecule metabolic process (GO:0044036)3.60414840
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.56219933
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.55668743
18L-phenylalanine catabolic process (GO:0006559)3.55668743
19cell adhesion mediated by integrin (GO:0033627)3.51659801
20respiratory chain complex IV assembly (GO:0008535)3.51548011
21replication fork processing (GO:0031297)3.50109045
22nuclear pore organization (GO:0006999)3.49733343
23proteasome assembly (GO:0043248)3.43034401
24erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.40913228
25L-phenylalanine metabolic process (GO:0006558)3.40913228
26NLS-bearing protein import into nucleus (GO:0006607)3.39920235
27kynurenine metabolic process (GO:0070189)3.39529161
28water-soluble vitamin biosynthetic process (GO:0042364)3.39136365
29complement activation, alternative pathway (GO:0006957)3.38469483
30prenylation (GO:0097354)3.36060904
31protein prenylation (GO:0018342)3.36060904
32regulation of cholesterol homeostasis (GO:2000188)3.35950001
33cysteine metabolic process (GO:0006534)3.35038160
34platelet dense granule organization (GO:0060155)3.34338196
35protein carboxylation (GO:0018214)3.34131937
36peptidyl-glutamic acid carboxylation (GO:0017187)3.34131937
37aromatic amino acid family catabolic process (GO:0009074)3.32884071
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.32827993
39branched-chain amino acid catabolic process (GO:0009083)3.29622197
40regulation of protein activation cascade (GO:2000257)3.28415461
41positive regulation of protein autophosphorylation (GO:0031954)3.28339408
42plasma lipoprotein particle clearance (GO:0034381)3.26478833
43keratinocyte development (GO:0003334)3.25358181
44nitrogen cycle metabolic process (GO:0071941)3.25038085
45inositol phosphate catabolic process (GO:0071545)3.20850152
46protein K11-linked deubiquitination (GO:0035871)3.20183555
47regulation of cholesterol storage (GO:0010885)3.19284539
48regulation of translational termination (GO:0006449)3.18018085
49macroautophagy (GO:0016236)3.16495725
50phospholipid homeostasis (GO:0055091)3.14115552
51intraciliary transport (GO:0042073)3.11741027
52regulation of fatty acid beta-oxidation (GO:0031998)3.09868792
53regulation of complement activation (GO:0030449)3.09764398
54pre-miRNA processing (GO:0031054)3.08881483
55tryptophan metabolic process (GO:0006568)3.07408200
56tryptophan catabolic process (GO:0006569)3.06785803
57indole-containing compound catabolic process (GO:0042436)3.06785803
58indolalkylamine catabolic process (GO:0046218)3.06785803
59modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.05785734
60positive regulation by organism of defense response of other organism involved in symbiotic interact3.05785734
61modulation by symbiont of host immune response (GO:0052553)3.05785734
62positive regulation by symbiont of host defense response (GO:0052509)3.05785734
63modulation by symbiont of host defense response (GO:0052031)3.05785734
64modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.05785734
65cytochrome complex assembly (GO:0017004)3.04429477
66bile acid biosynthetic process (GO:0006699)3.03836838
67regulation of DNA endoreduplication (GO:0032875)3.03281337
68homocysteine metabolic process (GO:0050667)3.03048473
69regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.02758980
70regulation of mitotic spindle checkpoint (GO:1903504)3.02758980
71negative regulation of sterol transport (GO:0032372)3.01669320
72negative regulation of cholesterol transport (GO:0032375)3.01669320
73recombinational repair (GO:0000725)3.00087051
74double-strand break repair via homologous recombination (GO:0000724)2.99924575
75glycine metabolic process (GO:0006544)2.99804553
76cullin deneddylation (GO:0010388)2.99292521
77histone H2A acetylation (GO:0043968)2.99057749
78lysine metabolic process (GO:0006553)2.98816926
79lysine catabolic process (GO:0006554)2.98816926
80phospholipid efflux (GO:0033700)2.97675609
81serine family amino acid catabolic process (GO:0009071)2.97284853
82positive regulation of fatty acid beta-oxidation (GO:0032000)2.96035099
83protein-lipid complex assembly (GO:0065005)2.94156188
84signal peptide processing (GO:0006465)2.91805132
85high-density lipoprotein particle remodeling (GO:0034375)2.91032862
86protein K6-linked ubiquitination (GO:0085020)2.90704091
87regulation of meiosis I (GO:0060631)2.90180028
88regulation of fibrinolysis (GO:0051917)2.89814820
89glyoxylate metabolic process (GO:0046487)2.89478521
90positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.89330761
91L-alpha-amino acid transmembrane transport (GO:1902475)2.89235069
92plasma lipoprotein particle assembly (GO:0034377)2.89176869
93protein localization to endosome (GO:0036010)2.87108211
94regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.84639787
95regulation of cilium movement (GO:0003352)2.84551481
96sulfur amino acid catabolic process (GO:0000098)2.84434255
97female gonad development (GO:0008585)2.84065911
98myelin assembly (GO:0032288)2.83006939
99reverse cholesterol transport (GO:0043691)2.82350718
100cytoplasmic mRNA processing body assembly (GO:0033962)2.81473606
101synapsis (GO:0007129)2.81136378
102regulation of protein polyubiquitination (GO:1902914)2.79636750
103cilium morphogenesis (GO:0060271)2.77709294
104epithelial cell differentiation involved in prostate gland development (GO:0060742)2.77676013
105midgut development (GO:0007494)2.77018241
106germ cell migration (GO:0008354)2.76218511
107DNA catabolic process, exonucleolytic (GO:0000738)2.75399582
108somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.75002597
109isotype switching (GO:0045190)2.75002597
110somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.75002597
111protein localization to cilium (GO:0061512)2.74851277
112positive regulation of lipid catabolic process (GO:0050996)2.74281203
113negative regulation of neurological system process (GO:0031645)2.73626802
114regulation of interferon-beta biosynthetic process (GO:0045357)2.73482428
115L-fucose catabolic process (GO:0042355)2.71189860
116fucose catabolic process (GO:0019317)2.71189860
117L-fucose metabolic process (GO:0042354)2.71189860
118lipoprotein metabolic process (GO:0042157)2.70209263
119amino-acid betaine metabolic process (GO:0006577)2.69645470
120cholesterol efflux (GO:0033344)2.69345268
121apoptotic cell clearance (GO:0043277)2.68021341
122RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.67763187
123ketone body metabolic process (GO:1902224)2.66800709
124protein deneddylation (GO:0000338)2.66722372
125serine family amino acid metabolic process (GO:0009069)2.66612693
126anterograde synaptic vesicle transport (GO:0048490)2.64673623
127L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.64381536
128pore complex assembly (GO:0046931)2.63035843
129regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.62202908
130regulation of RNA export from nucleus (GO:0046831)2.62157041
131maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.60645659
132polyol catabolic process (GO:0046174)2.60146428
133bile acid metabolic process (GO:0008206)2.59770208
134heterochromatin organization (GO:0070828)2.59732317
135brain morphogenesis (GO:0048854)2.58858533
136presynaptic membrane assembly (GO:0097105)2.58788271
137regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.58229086
138cellular modified amino acid catabolic process (GO:0042219)2.57735315
139nonmotile primary cilium assembly (GO:0035058)2.56823067
140positive regulation of interferon-alpha production (GO:0032727)2.56670752
141negative regulation of lipid transport (GO:0032369)2.56429195
142tyrosine metabolic process (GO:0006570)2.56059886
143regulation of nuclear cell cycle DNA replication (GO:0033262)2.55677866
144inositol phosphate dephosphorylation (GO:0046855)2.55210470
145phosphorylated carbohydrate dephosphorylation (GO:0046838)2.55210470
146regulation of triglyceride catabolic process (GO:0010896)2.54920148
147serine family amino acid biosynthetic process (GO:0009070)2.54609170
148regulation of acyl-CoA biosynthetic process (GO:0050812)2.54585790
149resolution of meiotic recombination intermediates (GO:0000712)2.54276360
150peptidyl-cysteine modification (GO:0018198)2.52961864
151mitotic sister chromatid cohesion (GO:0007064)2.52917177
152monoubiquitinated protein deubiquitination (GO:0035520)2.52818349
153negative regulation of fatty acid biosynthetic process (GO:0045717)2.52511366
154somatic hypermutation of immunoglobulin genes (GO:0016446)2.52232525
155somatic diversification of immune receptors via somatic mutation (GO:0002566)2.52232525
156detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.52194991
157response to X-ray (GO:0010165)2.52146026
158regulation of membrane protein ectodomain proteolysis (GO:0051043)2.52084417
159positive regulation of SMAD protein import into nucleus (GO:0060391)2.51230388
160kidney morphogenesis (GO:0060993)2.51203734
161regulation of hippo signaling (GO:0035330)2.50486516
162positive regulation of glycolytic process (GO:0045821)2.50185232
163negative regulation of JUN kinase activity (GO:0043508)2.50019869
164regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.49934076
165acylglycerol homeostasis (GO:0055090)2.49749022
166triglyceride homeostasis (GO:0070328)2.49749022
167cellular ketone body metabolic process (GO:0046950)2.49717047
168chaperone-mediated protein complex assembly (GO:0051131)2.49004027
169telomere maintenance via telomerase (GO:0007004)2.48787481
170melanosome transport (GO:0032402)2.48771642
171hippo signaling (GO:0035329)2.48681984
172microtubule anchoring (GO:0034453)2.48445926
173intestinal cholesterol absorption (GO:0030299)2.48249759
174peptidyl-histidine modification (GO:0018202)2.48013880
175glutamate metabolic process (GO:0006536)2.47936837
176zinc ion transport (GO:0006829)2.44227643
177parental behavior (GO:0060746)2.43574887
178regulation of type B pancreatic cell apoptotic process (GO:2000674)2.41635563
179regulation of translation, ncRNA-mediated (GO:0045974)2.41577931
180negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.41577931
181negative regulation of translation, ncRNA-mediated (GO:0040033)2.41577931
182aldehyde catabolic process (GO:0046185)2.40775312
183lipid particle organization (GO:0034389)2.39948833
184rRNA methylation (GO:0031167)2.38918303
185photoreceptor cell maintenance (GO:0045494)2.38588143
186non-recombinational repair (GO:0000726)2.38563741
187double-strand break repair via nonhomologous end joining (GO:0006303)2.38563741
188cilium organization (GO:0044782)2.38032992
189cilium assembly (GO:0042384)2.36203777
190pigment granule transport (GO:0051904)2.35404973
191histone exchange (GO:0043486)2.35137154
192chromatin remodeling at centromere (GO:0031055)2.35112111
193regulation of telomere maintenance (GO:0032204)2.34418748
194regulation of sulfur metabolic process (GO:0042762)2.34129809
195negative regulation of telomere maintenance (GO:0032205)2.33906198
196ribosome assembly (GO:0042255)2.33839219
197attachment of spindle microtubules to kinetochore (GO:0008608)2.33700507
198branched-chain amino acid metabolic process (GO:0009081)2.32778683

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.33259102
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.25912545
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.02934407
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.91290004
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.67258946
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.42068501
7ZNF274_21170338_ChIP-Seq_K562_Hela3.02150915
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.97485761
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.86292816
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.69560151
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.68375506
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.55966043
13CLOCK_20551151_ChIP-Seq_293T_Human2.54310865
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.53910468
15E2F7_22180533_ChIP-Seq_HELA_Human2.53223067
16VDR_22108803_ChIP-Seq_LS180_Human2.50708345
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.46306573
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.44280247
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.44118762
20* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.43648731
21GBX2_23144817_ChIP-Seq_PC3_Human2.38394454
22IRF8_22096565_ChIP-ChIP_GC-B_Human2.36018858
23FUS_26573619_Chip-Seq_HEK293_Human2.34489048
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.32113883
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.20488319
26EWS_26573619_Chip-Seq_HEK293_Human2.18984380
27ELK1_19687146_ChIP-ChIP_HELA_Human2.16998326
28GABP_17652178_ChIP-ChIP_JURKAT_Human2.15607502
29P300_19829295_ChIP-Seq_ESCs_Human2.14118305
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.12404035
31TAF15_26573619_Chip-Seq_HEK293_Human2.05588848
32IGF1R_20145208_ChIP-Seq_DFB_Human2.05501386
33EST1_17652178_ChIP-ChIP_JURKAT_Human2.04031471
34PCGF2_27294783_Chip-Seq_ESCs_Mouse2.01579340
35NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.00929666
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.99199836
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95837940
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94899748
39FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.93960823
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93330217
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82407157
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.82261161
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79545469
44TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73801280
45ZNF263_19887448_ChIP-Seq_K562_Human1.73182672
46MYC_22102868_ChIP-Seq_BL_Human1.70831313
47IRF8_27001747_Chip-Seq_BMDM_Mouse1.69468933
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.68541745
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.65437359
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.64609335
51SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64268768
52SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.62081065
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.61891743
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61008656
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60778345
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59391652
57ER_23166858_ChIP-Seq_MCF-7_Human1.59174467
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.58997450
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.58636179
60SMAD4_21799915_ChIP-Seq_A2780_Human1.58383897
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56501403
62TCF7_22412390_ChIP-Seq_EML_Mouse1.54753797
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54554782
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.53670009
65E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53578921
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.53260246
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.52812209
68BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51946967
69BCAT_22108803_ChIP-Seq_LS180_Human1.51599351
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50455228
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.48769717
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.47541298
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46402877
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46393770
75RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45855181
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.45635255
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45619062
78CBP_20019798_ChIP-Seq_JUKART_Human1.45619062
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44924166
80* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.44211291
81RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42066291
82FOXA2_19822575_ChIP-Seq_HepG2_Human1.41061675
83CRX_20693478_ChIP-Seq_RETINA_Mouse1.39415007
84RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38710177
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.38508386
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37463808
87STAT3_23295773_ChIP-Seq_U87_Human1.37433711
88VDR_23849224_ChIP-Seq_CD4+_Human1.36983855
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36898300
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36266991
91TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.35989086
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.35600890
93TP63_17297297_ChIP-ChIP_HaCaT_Human1.35385789
94MYB_21317192_ChIP-Seq_ERMYB_Mouse1.35290090
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35208815
96AR_25329375_ChIP-Seq_VCAP_Human1.35180366
97P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35078985
98AR_21909140_ChIP-Seq_LNCAP_Human1.33852208
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.33335183
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32404440
101SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.32194966
102CDX2_22108803_ChIP-Seq_LS180_Human1.31081317
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30635992
104SMAD3_21741376_ChIP-Seq_EPCs_Human1.30600108
105TCF4_22108803_ChIP-Seq_LS180_Human1.30501881
106SOX2_19829295_ChIP-Seq_ESCs_Human1.30335888
107NANOG_19829295_ChIP-Seq_ESCs_Human1.30335888
108NOTCH1_21737748_ChIP-Seq_TLL_Human1.30293239
109PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29066622
110CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28607059
111FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.28309413
112RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28136918
113PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27807735
114NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.26503410
115EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26428976
116P53_22387025_ChIP-Seq_ESCs_Mouse1.26218408
117GATA6_25053715_ChIP-Seq_YYC3_Human1.26084197
118TCF4_23295773_ChIP-Seq_U87_Human1.25041774
119FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24283500
120SOX2_27498859_Chip-Seq_STOMACH_Mouse1.23151779
121KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22657844
122TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22564227
123POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22435491
124TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21195010
125SUZ12_18555785_Chip-Seq_ESCs_Mouse1.20398833
126ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.20302151
127SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.20083587
128SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.20083587
129KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19408135
130HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18941001
131P300_18555785_Chip-Seq_ESCs_Mouse1.17458860
132E2F1_18555785_Chip-Seq_ESCs_Mouse1.17226271
133OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17070835
134CMYC_18555785_Chip-Seq_ESCs_Mouse1.16543025
135STAT3_18555785_Chip-Seq_ESCs_Mouse1.16277602
136KDM2B_26808549_Chip-Seq_DND41_Human1.16202514
137GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15786306
138SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15669411
139PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15620084
140KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15477856
141FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15206995
142SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.14524289
143BRD4_25478319_ChIP-Seq_HGPS_Human1.13939889
144TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13766055
145CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13157028
146FLI1_21867929_ChIP-Seq_TH2_Mouse1.12671585
147ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12376627
148ATF3_27146783_Chip-Seq_COLON_Human1.12338379
149FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11910232
150TP53_22573176_ChIP-Seq_HFKS_Human1.10734412
151ESR1_21235772_ChIP-Seq_MCF-7_Human1.10498237
152TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09863637
153NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09367591
154MYC_18940864_ChIP-ChIP_HL60_Human1.09288339
155STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08305734
156IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07226691
157TFEB_21752829_ChIP-Seq_HELA_Human1.07164476
158MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06015855
159SOX2_18555785_Chip-Seq_ESCs_Mouse1.05959710
160IRF1_19129219_ChIP-ChIP_H3396_Human1.05455434
161EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04957448
162SMAD4_21741376_ChIP-Seq_EPCs_Human1.04677000
163RUNX2_22187159_ChIP-Seq_PCA_Human1.04657250
164PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04043297
165EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02932503
166CHD1_26751641_Chip-Seq_LNCaP_Human1.02014448
167FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01966675
168OCT4_18555785_Chip-Seq_ESCs_Mouse1.01727681
169HNF4A_19822575_ChIP-Seq_HepG2_Human1.01122909
170ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00052829
171PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99716248
172NCOR1_26117541_ChIP-Seq_K562_Human0.99671093
173TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99532185
174PU_27001747_Chip-Seq_BMDM_Mouse0.99028109
175HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98659414
176STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.98546655
177TRIM28_21343339_ChIP-Seq_HEK293_Human0.98461113
178ELK3_25401928_ChIP-Seq_HUVEC_Human0.97396815
179POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96084322
180GATA1_22025678_ChIP-Seq_K562_Human0.95150229
181UBF1/2_26484160_Chip-Seq_HMECs_Human0.94101234
182DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93969130
183NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93502508
184TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90450950
185CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89397608
186NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89122459
187TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87218616
188KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86277426
189ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86045073
190E2F1_21310950_ChIP-Seq_MCF-7_Human0.84940327
191FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.84324197
192MAF_26560356_Chip-Seq_TH1_Human0.83023319
193GATA2_21666600_ChIP-Seq_HMVEC_Human0.82807804
194GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.82720878
195GATA4_25053715_ChIP-Seq_YYC3_Human0.82376453
196KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82338374

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.56317055
2MP0005360_urolithiasis4.25034435
3MP0003705_abnormal_hypodermis_morpholog4.04984497
4MP0010234_abnormal_vibrissa_follicle3.35850209
5MP0010352_gastrointestinal_tract_polyps3.31536085
6MP0005365_abnormal_bile_salt3.23651232
7MP0005085_abnormal_gallbladder_physiolo3.19910065
8MP0008877_abnormal_DNA_methylation3.18936072
9MP0002102_abnormal_ear_morphology3.15385478
10MP0000372_irregular_coat_pigmentation2.99443737
11MP0003252_abnormal_bile_duct2.77357577
12MP0002938_white_spotting2.43686214
13MP0009840_abnormal_foam_cell2.40078497
14MP0003300_gastrointestinal_ulcer2.36309980
15MP0008058_abnormal_DNA_repair2.32613635
16MP0001984_abnormal_olfaction2.32397852
17MP0010307_abnormal_tumor_latency2.29373910
18MP0010329_abnormal_lipoprotein_level2.28383682
19MP0003787_abnormal_imprinting2.27377080
20MP0006072_abnormal_retinal_apoptosis2.24921821
21MP0000569_abnormal_digit_pigmentation2.10175530
22MP0008875_abnormal_xenobiotic_pharmacok2.07759538
23MP0005076_abnormal_cell_differentiation2.07727835
24MP0005083_abnormal_biliary_tract2.03645109
25MP0003303_peritoneal_inflammation2.00975484
26MP0002837_dystrophic_cardiac_calcinosis1.97832265
27MP0005551_abnormal_eye_electrophysiolog1.91721785
28MP0003121_genomic_imprinting1.90261226
29MP0000427_abnormal_hair_cycle1.88336885
30MP0009053_abnormal_anal_canal1.82754085
31MP0009780_abnormal_chondrocyte_physiolo1.82586464
32MP0005253_abnormal_eye_physiology1.82023040
33MP0005075_abnormal_melanosome_morpholog1.79792925
34MP0003191_abnormal_cellular_cholesterol1.79570067
35MP0010094_abnormal_chromosome_stability1.76255314
36MP0005174_abnormal_tail_pigmentation1.75071612
37MP0003566_abnormal_cell_adhesion1.70647617
38MP0003122_maternal_imprinting1.69660833
39MP0000015_abnormal_ear_pigmentation1.64680646
40MP0008057_abnormal_DNA_replication1.63354555
41MP0000609_abnormal_liver_physiology1.60094659
42MP0003880_abnormal_central_pattern1.59977588
43MP0003718_maternal_effect1.57501395
44MP0005084_abnormal_gallbladder_morpholo1.55890714
45MP0005058_abnormal_lysosome_morphology1.54656552
46MP0003011_delayed_dark_adaptation1.54336576
47MP0003806_abnormal_nucleotide_metabolis1.53487268
48MP0005623_abnormal_meninges_morphology1.51869325
49MP0001666_abnormal_nutrient_absorption1.46851361
50MP0001324_abnormal_eye_pigmentation1.43586024
51MP0003091_abnormal_cell_migration1.42308994
52MP0002138_abnormal_hepatobiliary_system1.41542001
53MP0002090_abnormal_vision1.36576036
54MP0002751_abnormal_autonomic_nervous1.31964347
55MP0008789_abnormal_olfactory_epithelium1.28475947
56MP0000598_abnormal_liver_morphology1.28435466
57MP0001915_intracranial_hemorrhage1.27711562
58MP0003786_premature_aging1.26615725
59MP0003453_abnormal_keratinocyte_physiol1.26030921
60MP0009046_muscle_twitch1.24601648
61MP0002877_abnormal_melanocyte_morpholog1.24062699
62MP0009278_abnormal_bone_marrow1.21678804
63MP0005248_abnormal_Harderian_gland1.21204675
64MP0000647_abnormal_sebaceous_gland1.20781378
65MP0004019_abnormal_vitamin_homeostasis1.20702234
66MP0005646_abnormal_pituitary_gland1.20471606
67MP0000733_abnormal_muscle_development1.19530945
68MP0001485_abnormal_pinna_reflex1.19017237
69MP0002095_abnormal_skin_pigmentation1.18633329
70MP0006292_abnormal_olfactory_placode1.18404861
71MP0005645_abnormal_hypothalamus_physiol1.18087764
72MP0005379_endocrine/exocrine_gland_phen1.17301978
73MP0005332_abnormal_amino_acid1.16599043
74MP0005023_abnormal_wound_healing1.16509995
75MP0005319_abnormal_enzyme/_coenzyme1.16407147
76MP0006036_abnormal_mitochondrial_physio1.14891625
77MP0004215_abnormal_myocardial_fiber1.13446814
78MP0003172_abnormal_lysosome_physiology1.12831169
79MP0002909_abnormal_adrenal_gland1.12155198
80MP0000604_amyloidosis1.09274101
81MP0002086_abnormal_extraembryonic_tissu1.09139108
82MP0003436_decreased_susceptibility_to1.08319215
83MP0001730_embryonic_growth_arrest1.08134615
84MP0002876_abnormal_thyroid_physiology1.08112877
85MP0002118_abnormal_lipid_homeostasis1.07954290
86MP0004197_abnormal_fetal_growth/weight/1.07730580
87MP0000631_abnormal_neuroendocrine_gland1.07611296
88MP0003567_abnormal_fetal_cardiomyocyte1.07560115
89MP0003195_calcinosis1.06764326
90MP0001929_abnormal_gametogenesis1.05250013
91MP0010678_abnormal_skin_adnexa1.04808370
92MP0005395_other_phenotype1.04371264
93MP0004043_abnormal_pH_regulation1.03684890
94MP0008438_abnormal_cutaneous_collagen1.02910411
95MP0000537_abnormal_urethra_morphology1.02677932
96MP0001545_abnormal_hematopoietic_system0.99991270
97MP0005397_hematopoietic_system_phenotyp0.99991270
98MP0004947_skin_inflammation0.98693048
99MP0000538_abnormal_urinary_bladder0.98668262
100MP0008007_abnormal_cellular_replicative0.98115289
101MP0002928_abnormal_bile_duct0.95769707
102MP0001849_ear_inflammation0.95639674
103MP0002736_abnormal_nociception_after0.95213622
104MP0002166_altered_tumor_susceptibility0.94778527
105MP0002088_abnormal_embryonic_growth/wei0.93849695
106MP0000653_abnormal_sex_gland0.92942004
107MP0004147_increased_porphyrin_level0.92768965
108MP0004130_abnormal_muscle_cell0.92628826
109MP0008872_abnormal_physiological_respon0.92574271
110MP0003868_abnormal_feces_composition0.92193833
111MP0003937_abnormal_limbs/digits/tail_de0.91786713
112MP0003186_abnormal_redox_activity0.91451316
113MP0003984_embryonic_growth_retardation0.91242947
114MP0001529_abnormal_vocalization0.90750710
115MP0002233_abnormal_nose_morphology0.90207373
116MP0001188_hyperpigmentation0.88858402
117MP0002163_abnormal_gland_morphology0.88432846
118MP0006054_spinal_hemorrhage0.88418072
119MP0004885_abnormal_endolymph0.88215265
120MP0000383_abnormal_hair_follicle0.87841930
121MP0005380_embryogenesis_phenotype0.87616118
122MP0001672_abnormal_embryogenesis/_devel0.87616118
123MP0009672_abnormal_birth_weight0.87528357
124MP0004264_abnormal_extraembryonic_tissu0.85295449
125MP0005167_abnormal_blood-brain_barrier0.84766889
126MP0002254_reproductive_system_inflammat0.84649101
127MP0002234_abnormal_pharynx_morphology0.84276564
128MP0006035_abnormal_mitochondrial_morpho0.83918025
129MP0008775_abnormal_heart_ventricle0.83851199
130MP0002638_abnormal_pupillary_reflex0.83409288
131MP0003890_abnormal_embryonic-extraembry0.83298015
132MP0008961_abnormal_basal_metabolism0.82076524
133MP0003448_altered_tumor_morphology0.81825103
134MP0001486_abnormal_startle_reflex0.81737604
135MP0002210_abnormal_sex_determination0.81680188
136MP0002168_other_aberrant_phenotype0.81494170
137MP0001944_abnormal_pancreas_morphology0.81427707
138MP0005408_hypopigmentation0.81142595
139MP0003693_abnormal_embryo_hatching0.80416281
140MP0002693_abnormal_pancreas_physiology0.79670625
141MP0001145_abnormal_male_reproductive0.79464346
142MP0001119_abnormal_female_reproductive0.79334952
143MP0004924_abnormal_behavior0.79123255
144MP0005386_behavior/neurological_phenoty0.79123255
145MP0003646_muscle_fatigue0.79092349
146MP0001986_abnormal_taste_sensitivity0.78940192
147MP0001293_anophthalmia0.78654757
148MP0003115_abnormal_respiratory_system0.78554776
149MP0000371_diluted_coat_color0.77968139
150MP0005464_abnormal_platelet_physiology0.77925261
151MP0003698_abnormal_male_reproductive0.77836185
152MP0005187_abnormal_penis_morphology0.77798917
153MP0003943_abnormal_hepatobiliary_system0.77389801
154MP0005367_renal/urinary_system_phenotyp0.76824296
155MP0000516_abnormal_urinary_system0.76824296
156MP0003136_yellow_coat_color0.75667378
157MP0009643_abnormal_urine_homeostasis0.75002106
158MP0006082_CNS_inflammation0.75000822
159MP0002557_abnormal_social/conspecific_i0.74951914
160MP0003950_abnormal_plasma_membrane0.74272569
161MP0004185_abnormal_adipocyte_glucose0.74136166
162MP0002084_abnormal_developmental_patter0.73863954
163MP0001697_abnormal_embryo_size0.72896489
164MP0009703_decreased_birth_body0.72114673
165MP0002697_abnormal_eye_size0.71969617
166MP0009697_abnormal_copulation0.71033961
167MP0010368_abnormal_lymphatic_system0.70915302
168MP0002092_abnormal_eye_morphology0.70339635
169MP0008469_abnormal_protein_level0.68625421
170MP0001881_abnormal_mammary_gland0.67949463
171MP0000350_abnormal_cell_proliferation0.67704666
172MP0002896_abnormal_bone_mineralization0.67231966
173MP0004808_abnormal_hematopoietic_stem0.66657164
174MP0002136_abnormal_kidney_physiology0.65256132
175MP0000627_abnormal_mammary_gland0.65227268
176MP0005220_abnormal_exocrine_pancreas0.62786634
177MP0009763_increased_sensitivity_to0.61664451
178MP0003690_abnormal_glial_cell0.61382711
179MP0000767_abnormal_smooth_muscle0.60939742
180MP0005621_abnormal_cell_physiology0.60513216
181MP0005166_decreased_susceptibility_to0.60441664

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.20105689
2Intrahepatic cholestasis (HP:0001406)3.90581694
3Abnormality of monocarboxylic acid metabolism (HP:0010996)3.83603402
4Xanthomatosis (HP:0000991)3.82472263
5Complement deficiency (HP:0004431)3.67543024
6Myocardial infarction (HP:0001658)3.54751999
7Intestinal atresia (HP:0011100)3.32273233
8Hypobetalipoproteinemia (HP:0003563)3.24521220
9Epidermoid cyst (HP:0200040)3.23957226
10Pancreatic cysts (HP:0001737)3.21016060
11Hypothermia (HP:0002045)3.20784365
12Abnormality of glutamine family amino acid metabolism (HP:0010902)3.11071036
13Hyperinsulinemic hypoglycemia (HP:0000825)2.97481894
14Methylmalonic acidemia (HP:0002912)2.96185081
15Abnormality of midbrain morphology (HP:0002418)2.95777629
16Molar tooth sign on MRI (HP:0002419)2.95777629
17Volvulus (HP:0002580)2.94453263
18Medial flaring of the eyebrow (HP:0010747)2.93079488
19Abnormality of complement system (HP:0005339)2.91200661
20Hypercholesterolemia (HP:0003124)2.89164113
21Pancreatic fibrosis (HP:0100732)2.86413052
22Hypolipoproteinemia (HP:0010981)2.83049737
23Abnormality of the common coagulation pathway (HP:0010990)2.82509894
24Subacute progressive viral hepatitis (HP:0006572)2.81568983
25Hematochezia (HP:0002573)2.78939793
26Hypoalphalipoproteinemia (HP:0003233)2.78390262
27Abnormality of the labia minora (HP:0012880)2.78273949
28Spastic diplegia (HP:0001264)2.77080217
29True hermaphroditism (HP:0010459)2.76373949
30Disinhibition (HP:0000734)2.72121283
31Systemic lupus erythematosus (HP:0002725)2.70823365
32Ependymoma (HP:0002888)2.67202617
33Abnormality of aromatic amino acid family metabolism (HP:0004338)2.66055434
34Esophageal varix (HP:0002040)2.65125954
35Abnormality of sulfur amino acid metabolism (HP:0004339)2.60273010
36Hand muscle atrophy (HP:0009130)2.58993775
37Nephronophthisis (HP:0000090)2.58787911
38Abnormality of chromosome stability (HP:0003220)2.58650908
39Abnormality of the renal cortex (HP:0011035)2.56540521
40Back pain (HP:0003418)2.56040767
41Upper motor neuron abnormality (HP:0002127)2.55313195
42Cortical dysplasia (HP:0002539)2.55069010
43Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.54522874
44Fat malabsorption (HP:0002630)2.52827896
45Recurrent gram-negative bacterial infections (HP:0005420)2.52706908
46Neoplasm of the adrenal gland (HP:0100631)2.50862411
47Astrocytoma (HP:0009592)2.50221050
48Abnormality of the astrocytes (HP:0100707)2.50221050
49Congenital primary aphakia (HP:0007707)2.49071148
50Ketoacidosis (HP:0001993)2.48492418
51Aqueductal stenosis (HP:0002410)2.48314680
52Cerebral aneurysm (HP:0004944)2.48165851
53Increased CSF protein (HP:0002922)2.42775063
54Gait imbalance (HP:0002141)2.41671357
55Hyperlipoproteinemia (HP:0010980)2.39750237
56Hepatocellular carcinoma (HP:0001402)2.39703882
57Glioma (HP:0009733)2.37791784
58Abnormality of proline metabolism (HP:0010907)2.37541034
59Hydroxyprolinuria (HP:0003080)2.37541034
60Skin nodule (HP:0200036)2.37072002
61Methylmalonic aciduria (HP:0012120)2.36516104
62Aplasia/Hypoplasia of the uvula (HP:0010293)2.35561593
63Abnormality of the renal medulla (HP:0100957)2.32726374
64Abnormality of the pancreatic islet cells (HP:0006476)2.30915741
65Abnormality of endocrine pancreas physiology (HP:0012093)2.30915741
66Macroorchidism (HP:0000053)2.30532303
67Pancreatic islet-cell hyperplasia (HP:0004510)2.29986949
68Distal upper limb amyotrophy (HP:0007149)2.29346443
69Upper limb amyotrophy (HP:0009129)2.29346443
70Aplasia/Hypoplasia of the fovea (HP:0008060)2.25282692
71Hypoplasia of the fovea (HP:0007750)2.25282692
72Genital tract atresia (HP:0001827)2.24489396
73Median cleft lip (HP:0000161)2.24306366
74Lymphangioma (HP:0100764)2.23367560
75Symptomatic seizures (HP:0011145)2.22777984
76Focal segmental glomerulosclerosis (HP:0000097)2.22317396
77Abnormality of vitamin B metabolism (HP:0004340)2.22128751
78Progressive macrocephaly (HP:0004481)2.21373332
79Meckel diverticulum (HP:0002245)2.20895864
80Albinism (HP:0001022)2.20810168
81Increased cerebral lipofuscin (HP:0011813)2.20577594
82Enlarged penis (HP:0000040)2.19886191
83Abnormality of the metopic suture (HP:0005556)2.19781842
84Increased mean platelet volume (HP:0011877)2.19100587
85Nephrogenic diabetes insipidus (HP:0009806)2.18234986
86Joint hemorrhage (HP:0005261)2.17717248
87Abnormality of the ileum (HP:0001549)2.16947022
88Cutaneous melanoma (HP:0012056)2.16108014
89Thyroiditis (HP:0100646)2.14752734
90Gaze-evoked nystagmus (HP:0000640)2.11514062
91Prominent metopic ridge (HP:0005487)2.11030227
92Vaginal atresia (HP:0000148)2.10935244
93Colon cancer (HP:0003003)2.10746086
94Pseudobulbar signs (HP:0002200)2.09905376
95Abnormality of the intrinsic pathway (HP:0010989)2.09308535
96Congenital stationary night blindness (HP:0007642)2.07861167
97Autoimmune thrombocytopenia (HP:0001973)2.07503941
98Hypomagnesemia (HP:0002917)2.05418554
99Large for gestational age (HP:0001520)2.03250021
100Osteolytic defects of the hand bones (HP:0009699)2.03127809
101Osteolytic defects of the phalanges of the hand (HP:0009771)2.03127809
102Progressive inability to walk (HP:0002505)2.02807990
103Mitral valve prolapse (HP:0001634)2.02795926
104Abnormality of the fovea (HP:0000493)2.01791947
105Tubular atrophy (HP:0000092)2.00990060
106Hyperglycemia (HP:0003074)2.00110264
107Abnormality of the lower motor neuron (HP:0002366)1.99621461
108Abnormality of pyrimidine metabolism (HP:0004353)1.99192327
109Tubulointerstitial nephritis (HP:0001970)1.96653489
110Asymmetry of the thorax (HP:0001555)1.96131649
111Global brain atrophy (HP:0002283)1.95851152
112Conjunctival telangiectasia (HP:0000524)1.95048291
113Renal cortical cysts (HP:0000803)1.94865382
114Mitral stenosis (HP:0001718)1.94846955
115Tongue fasciculations (HP:0001308)1.94170239
116Type II lissencephaly (HP:0007260)1.93564115
117Glomerulonephritis (HP:0000099)1.93493593
118Abnormality of the preputium (HP:0100587)1.92854349
119Bifid tongue (HP:0010297)1.92628976
120Abnormal drinking behavior (HP:0030082)1.92374665
121Polydipsia (HP:0001959)1.92374665
122Aplasia/Hypoplasia of the tongue (HP:0010295)1.91870122
123Furrowed tongue (HP:0000221)1.91725814
124Acute necrotizing encephalopathy (HP:0006965)1.90889102
125Postaxial hand polydactyly (HP:0001162)1.90548853
126Steatorrhea (HP:0002570)1.90404646
127Metaphyseal cupping (HP:0003021)1.89141082
128Glomerulosclerosis (HP:0000096)1.88402984
129Adrenal hypoplasia (HP:0000835)1.88393021
130Turricephaly (HP:0000262)1.87801065
131Abnormality of the vitamin B12 metabolism (HP:0004341)1.87393107
132Hyperammonemia (HP:0001987)1.87378558
133Acute encephalopathy (HP:0006846)1.86911348
134Nephritis (HP:0000123)1.86707336
135Abnormality of nucleobase metabolism (HP:0010932)1.86455127
136Abnormal platelet volume (HP:0011876)1.85784449
137Hamartoma of the eye (HP:0010568)1.85351923
138Sloping forehead (HP:0000340)1.85297895
139Gastrointestinal atresia (HP:0002589)1.85252082
140Breast carcinoma (HP:0003002)1.84197446
141Abnormality of the vasculature of the conjunctiva (HP:0008054)1.84097950
142Peripheral demyelination (HP:0011096)1.84004448
143Abnormality of the duodenum (HP:0002246)1.83011049
144Abnormality of the Achilles tendon (HP:0005109)1.82687419
145Aplasia/Hypoplasia of the tibia (HP:0005772)1.81804743
146Prolonged partial thromboplastin time (HP:0003645)1.81296702
147Increased CSF lactate (HP:0002490)1.80438931
148Biliary tract neoplasm (HP:0100574)1.80273792
149Abnormality of purine metabolism (HP:0004352)1.80086526
150Rhabdomyosarcoma (HP:0002859)1.79557496
151Poor coordination (HP:0002370)1.79171631
152Labial hypoplasia (HP:0000066)1.79044132
153Abnormality of aspartate family amino acid metabolism (HP:0010899)1.78639497
154Hyperventilation (HP:0002883)1.78594141
155Chronic hepatic failure (HP:0100626)1.77022248
156Small hand (HP:0200055)1.76783817
157Abolished electroretinogram (ERG) (HP:0000550)1.76153964
158Disproportionate short-trunk short stature (HP:0003521)1.75746215
159Astigmatism (HP:0000483)1.74415405
160Postaxial foot polydactyly (HP:0001830)1.73563491
161Hypoplastic female external genitalia (HP:0012815)1.72296615
162Duodenal stenosis (HP:0100867)1.70921832
163Small intestinal stenosis (HP:0012848)1.70921832
164Urinary glycosaminoglycan excretion (HP:0003541)1.69978211
165Mucopolysacchariduria (HP:0008155)1.69978211
166Preaxial hand polydactyly (HP:0001177)1.69912357
167Congenital hepatic fibrosis (HP:0002612)1.69843192
168Abnormality of methionine metabolism (HP:0010901)1.68398511
169Delayed gross motor development (HP:0002194)1.68234052
170Hypoplastic labia majora (HP:0000059)1.68154363
171Hemorrhage of the eye (HP:0011885)1.67790114
172Hypoglycemic seizures (HP:0002173)1.67111730
173Heterotopia (HP:0002282)1.67057303
174Hypoglycemic coma (HP:0001325)1.65593802
175Coarse hair (HP:0002208)1.65536243
176Dilatation of the ascending aorta (HP:0005111)1.65486747
177Hypochromic microcytic anemia (HP:0004840)1.64951334
178Micronodular cirrhosis (HP:0001413)1.64601885
179Ulnar bowing (HP:0003031)1.61683592
180Axonal loss (HP:0003447)1.60716838
181Shallow orbits (HP:0000586)1.59822207
182Arterial thrombosis (HP:0004420)1.58049821
183Sensorimotor neuropathy (HP:0007141)1.57766693
184Aneurysm (HP:0002617)1.57714103
185Ketosis (HP:0001946)1.56831614
186Neoplasm of the adrenal cortex (HP:0100641)1.56798108
187Gingival bleeding (HP:0000225)1.53558514
188Gastrointestinal carcinoma (HP:0002672)1.53528594
189Malignant gastrointestinal tract tumors (HP:0006749)1.53528594
190Termporal pattern (HP:0011008)1.53349183
191Insidious onset (HP:0003587)1.53349183
192Gout (HP:0001997)1.53264470
193Spinal cord lesions (HP:0100561)1.51829940

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.57823959
2TRIB33.50227229
3PKN23.16774117
4EIF2AK33.13091354
5WNK32.97509383
6CDK122.87848190
7MST42.72710738
8ACVR1B2.72532786
9LATS12.68679161
10MAP4K22.65413924
11SCYL22.60705667
12BMPR1B2.55347351
13MKNK22.31701761
14FRK2.31479462
15PTK62.14442640
16PLK22.11463657
17MAP3K102.07479084
18RIPK12.01079952
19EEF2K2.00279511
20TNIK1.98668304
21WEE11.82110849
22BMX1.75364605
23TTN1.73500519
24FGFR21.72646114
25BUB11.70948106
26ERN11.69832220
27STK31.68188616
28CAMK1D1.64059486
29PDGFRA1.62052022
30CDK61.58921773
31STK391.57550240
32EPHA21.57441168
33FGFR41.57319045
34EIF2AK11.49720791
35GRK11.45754480
36PAK31.45049710
37STK101.41811783
38MKNK11.38409664
39PDK31.37007446
40PDK41.37007446
41CASK1.36112470
42ZAK1.35940031
43MAP3K21.34800040
44OXSR11.34569707
45NEK91.33965641
46FGFR31.31556950
47NEK11.31467680
48MAP3K41.30954799
49ADRBK21.27489617
50ALK1.27283224
51MTOR1.27160462
52INSRR1.26137215
53PINK11.24606419
54PLK41.24544699
55BCR1.23936773
56TBK11.22829971
57SIK11.19461907
58MAPK131.17412858
59CAMK1G1.14008658
60MAP3K141.12761729
61ERBB41.12420983
62LRRK21.12238750
63NEK21.11697244
64CSNK1G11.11551997
65PDK21.10729317
66RPS6KA41.10192333
67ICK1.08831616
68PRKD31.05347099
69TYK21.03801094
70MET1.01715008
71PAK41.01085312
72PRKCE0.99129192
73MST1R0.98002295
74DYRK1B0.96671841
75JAK10.95440209
76EIF2AK20.95304125
77TAF10.95296846
78TESK10.94813546
79EPHA40.91221242
80TGFBR20.87218437
81MAP3K80.86984566
82CSNK1G20.86781122
83RET0.86587133
84PDGFRB0.86323578
85NLK0.84899772
86MAP3K120.84056570
87AKT30.83982260
88TTK0.81361732
89CSNK1G30.81136727
90CHUK0.80950829
91PBK0.80732617
92PLK10.80716161
93EGFR0.80179927
94STK160.79419555
95PTK20.76555762
96MAP3K50.76520461
97PNCK0.75600089
98BRSK20.74794854
99MAP3K30.74790142
100FGFR10.74385723
101CSNK1A1L0.73319664
102SGK30.71590322
103JAK20.70791389
104LATS20.70731855
105CAMKK10.69005569
106TRPM70.67787647
107BRD40.65941515
108KSR20.64234338
109VRK10.63347375
110TGFBR10.63192726
111ERBB30.62617182
112STK240.61796325
113PAK20.60395888
114CDK40.60313706
115FLT30.59243549
116RPS6KB20.59048993
117WNK40.58262291
118DDR20.56261410
119SRPK10.56230322
120GSK3A0.55966138
121TYRO30.55598307
122FER0.55580222
123PRKCG0.55483677
124PTK2B0.55256555
125PDK10.53675356
126MAP2K30.52700406
127STK380.51743153
128CSK0.51375908
129BRSK10.51277931
130PIM10.51166067
131YES10.51132717
132PHKG20.50306552
133PHKG10.50306552
134PDPK10.47639755
135PLK30.46347433
136SIK30.44798973
137CSNK1D0.44573276
138PASK0.43916222
139STK38L0.43713917
140MAP2K70.42895505
141MAP3K70.42632995
142CDK30.41793938
143RPS6KA10.41248817
144MAP3K110.40596704
145OBSCN0.40516979
146MAP2K40.39020397
147MUSK0.38877849
148EPHB10.37818829
149ADRBK10.36682198
150PRKCI0.36605266
151TAOK20.36597214
152CSNK1A10.36461616
153CDC70.35925456
154NTRK30.35820291
155TSSK60.35087691
156ATM0.34941884
157ATR0.34588519
158ERBB20.34534466
159NUAK10.34224776
160MAPK110.34116455
161PRKAA10.34070832
162KSR10.33510718
163CHEK10.33353194
164ABL20.33048716
165DYRK20.31799454
166CAMK2D0.30462481
167PRKAA20.30285784
168BCKDK0.30137077
169ROCK10.29613627
170IRAK10.29072249
171VRK20.27962556
172MINK10.27280979
173TEC0.26704940
174LIMK10.23305574
175CCNB10.22120937
176DAPK20.21787547
177PRKACB0.20928376
178CAMK2A0.20547095

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.92294713
2Protein export_Homo sapiens_hsa030603.55017108
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.21604479
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.11584233
5Non-homologous end-joining_Homo sapiens_hsa034502.93856794
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.90081556
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.75831709
8Proteasome_Homo sapiens_hsa030502.71979216
9Arginine biosynthesis_Homo sapiens_hsa002202.68128309
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.41933918
11Complement and coagulation cascades_Homo sapiens_hsa046102.33115082
12Homologous recombination_Homo sapiens_hsa034402.23985669
13Basal transcription factors_Homo sapiens_hsa030222.19524224
14Staphylococcus aureus infection_Homo sapiens_hsa051502.19136913
15Fanconi anemia pathway_Homo sapiens_hsa034602.14511380
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.10423905
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.99132296
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.96021777
19Fatty acid elongation_Homo sapiens_hsa000621.79165072
20Regulation of autophagy_Homo sapiens_hsa041401.75105404
21Selenocompound metabolism_Homo sapiens_hsa004501.73440601
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66162610
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.62295990
24RNA degradation_Homo sapiens_hsa030181.61799780
25Sulfur metabolism_Homo sapiens_hsa009201.61333264
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61160442
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59764817
28Phototransduction_Homo sapiens_hsa047441.59567222
29Steroid biosynthesis_Homo sapiens_hsa001001.59490730
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53435994
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.52637247
32Tryptophan metabolism_Homo sapiens_hsa003801.52117685
33PPAR signaling pathway_Homo sapiens_hsa033201.50986993
34Mismatch repair_Homo sapiens_hsa034301.50279931
35RNA polymerase_Homo sapiens_hsa030201.47667088
36Fatty acid degradation_Homo sapiens_hsa000711.47397097
37One carbon pool by folate_Homo sapiens_hsa006701.44580234
38Caffeine metabolism_Homo sapiens_hsa002321.43612348
39Lysine degradation_Homo sapiens_hsa003101.40148826
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.33548754
41Bile secretion_Homo sapiens_hsa049761.32682211
42Collecting duct acid secretion_Homo sapiens_hsa049661.31388398
43Oxidative phosphorylation_Homo sapiens_hsa001901.26626042
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25985973
45Circadian rhythm_Homo sapiens_hsa047101.25952913
46RNA transport_Homo sapiens_hsa030131.19824472
47Chronic myeloid leukemia_Homo sapiens_hsa052201.06807045
48Biosynthesis of amino acids_Homo sapiens_hsa012301.05589839
49Drug metabolism - other enzymes_Homo sapiens_hsa009831.04346161
50Fatty acid metabolism_Homo sapiens_hsa012121.03598779
51mTOR signaling pathway_Homo sapiens_hsa041501.03321924
52Ether lipid metabolism_Homo sapiens_hsa005651.03133597
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01345469
54Legionellosis_Homo sapiens_hsa051341.01036300
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99471260
56Insulin resistance_Homo sapiens_hsa049310.96253220
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95046207
58Fat digestion and absorption_Homo sapiens_hsa049750.94353885
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92724437
60Adherens junction_Homo sapiens_hsa045200.92125171
61Peroxisome_Homo sapiens_hsa041460.91858033
62Glutathione metabolism_Homo sapiens_hsa004800.91806043
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.91338060
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90301773
65Small cell lung cancer_Homo sapiens_hsa052220.89823649
66Proteoglycans in cancer_Homo sapiens_hsa052050.86890713
67Parkinsons disease_Homo sapiens_hsa050120.86550533
68Starch and sucrose metabolism_Homo sapiens_hsa005000.86082931
69Butanoate metabolism_Homo sapiens_hsa006500.81553850
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81350879
71Fatty acid biosynthesis_Homo sapiens_hsa000610.81253695
72Lysosome_Homo sapiens_hsa041420.81074788
73Oocyte meiosis_Homo sapiens_hsa041140.80627211
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.80613930
75Carbon metabolism_Homo sapiens_hsa012000.80050936
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79962488
77Insulin secretion_Homo sapiens_hsa049110.79716307
78Chemical carcinogenesis_Homo sapiens_hsa052040.79598793
79Purine metabolism_Homo sapiens_hsa002300.79582047
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.78864455
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78714658
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77819107
83Toxoplasmosis_Homo sapiens_hsa051450.76202735
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76012254
85Propanoate metabolism_Homo sapiens_hsa006400.74570563
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.74132556
87MicroRNAs in cancer_Homo sapiens_hsa052060.73984817
88Vitamin B6 metabolism_Homo sapiens_hsa007500.73779025
89Prion diseases_Homo sapiens_hsa050200.73713972
90Pyruvate metabolism_Homo sapiens_hsa006200.71680340
91p53 signaling pathway_Homo sapiens_hsa041150.71543703
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70924512
93Leishmaniasis_Homo sapiens_hsa051400.70095747
94beta-Alanine metabolism_Homo sapiens_hsa004100.69305379
95Nucleotide excision repair_Homo sapiens_hsa034200.68203526
96Linoleic acid metabolism_Homo sapiens_hsa005910.67844889
97Systemic lupus erythematosus_Homo sapiens_hsa053220.67375831
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66111538
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65765141
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65749526
101ABC transporters_Homo sapiens_hsa020100.65226730
102Viral carcinogenesis_Homo sapiens_hsa052030.64816404
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64812271
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.63554432
105Metabolic pathways_Homo sapiens_hsa011000.62999257
106Endometrial cancer_Homo sapiens_hsa052130.62865693
107Pancreatic cancer_Homo sapiens_hsa052120.62566470
108TNF signaling pathway_Homo sapiens_hsa046680.62042555
109Amoebiasis_Homo sapiens_hsa051460.61888903
110Osteoclast differentiation_Homo sapiens_hsa043800.61666971
111Antigen processing and presentation_Homo sapiens_hsa046120.61645780
112Phenylalanine metabolism_Homo sapiens_hsa003600.60318122
113Glioma_Homo sapiens_hsa052140.60167215
114Prostate cancer_Homo sapiens_hsa052150.57992027
115Glycerolipid metabolism_Homo sapiens_hsa005610.57781837
116Folate biosynthesis_Homo sapiens_hsa007900.57649990
117Apoptosis_Homo sapiens_hsa042100.57461048
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56697705
119Bladder cancer_Homo sapiens_hsa052190.55294646
120Hedgehog signaling pathway_Homo sapiens_hsa043400.54812965
121FoxO signaling pathway_Homo sapiens_hsa040680.54578598
122Focal adhesion_Homo sapiens_hsa045100.54397752
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54100480
124Pertussis_Homo sapiens_hsa051330.53836735
125Sphingolipid metabolism_Homo sapiens_hsa006000.53820427
126Dorso-ventral axis formation_Homo sapiens_hsa043200.53686762
127Huntingtons disease_Homo sapiens_hsa050160.52860981
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52556782
129Influenza A_Homo sapiens_hsa051640.51941061
130Vitamin digestion and absorption_Homo sapiens_hsa049770.51904263
131NF-kappa B signaling pathway_Homo sapiens_hsa040640.51436764
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51220632
133Prolactin signaling pathway_Homo sapiens_hsa049170.50829854
134Histidine metabolism_Homo sapiens_hsa003400.50210540
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49396480
136Cell cycle_Homo sapiens_hsa041100.49025945
137Hepatitis B_Homo sapiens_hsa051610.49011924
138Non-small cell lung cancer_Homo sapiens_hsa052230.48425421
139Pyrimidine metabolism_Homo sapiens_hsa002400.48339275
140Retinol metabolism_Homo sapiens_hsa008300.47976001
141Mineral absorption_Homo sapiens_hsa049780.47908711
142Glucagon signaling pathway_Homo sapiens_hsa049220.47723482
143B cell receptor signaling pathway_Homo sapiens_hsa046620.47722859
144AMPK signaling pathway_Homo sapiens_hsa041520.47521810
145Hippo signaling pathway_Homo sapiens_hsa043900.46782139
146Tuberculosis_Homo sapiens_hsa051520.45810753
147Renal cell carcinoma_Homo sapiens_hsa052110.45743004
148Hepatitis C_Homo sapiens_hsa051600.45711238
149Taste transduction_Homo sapiens_hsa047420.44860573
150Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44542616
151TGF-beta signaling pathway_Homo sapiens_hsa043500.44502221
152Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44288459
153Leukocyte transendothelial migration_Homo sapiens_hsa046700.44277662
154Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44041516
155Cyanoamino acid metabolism_Homo sapiens_hsa004600.43749612
156mRNA surveillance pathway_Homo sapiens_hsa030150.41917276
157SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38938085
158Nicotine addiction_Homo sapiens_hsa050330.35706051
159Olfactory transduction_Homo sapiens_hsa047400.33263643
160Serotonergic synapse_Homo sapiens_hsa047260.32394594
161Alzheimers disease_Homo sapiens_hsa050100.31450423
162DNA replication_Homo sapiens_hsa030300.30224667
163Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29969815
164Base excision repair_Homo sapiens_hsa034100.26180798
165Dopaminergic synapse_Homo sapiens_hsa047280.25292226
166N-Glycan biosynthesis_Homo sapiens_hsa005100.25142299

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