CACYBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.10030336
2maturation of SSU-rRNA (GO:0030490)4.81863954
3DNA strand elongation involved in DNA replication (GO:0006271)4.76329707
4DNA replication initiation (GO:0006270)4.69950959
5telomere maintenance via semi-conservative replication (GO:0032201)4.53784397
6DNA strand elongation (GO:0022616)4.51198522
7DNA unwinding involved in DNA replication (GO:0006268)4.39800328
8formation of translation preinitiation complex (GO:0001731)4.38873400
9ribosomal small subunit assembly (GO:0000028)4.34603233
10ATP synthesis coupled proton transport (GO:0015986)4.22504818
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.22504818
12nucleobase biosynthetic process (GO:0046112)4.19207505
13ribosomal large subunit biogenesis (GO:0042273)4.15549268
14DNA replication checkpoint (GO:0000076)4.14060945
15ribosome assembly (GO:0042255)4.05363310
16chromatin remodeling at centromere (GO:0031055)4.05028247
17DNA deamination (GO:0045006)4.04862831
18ribosome biogenesis (GO:0042254)4.03915625
19chaperone-mediated protein transport (GO:0072321)4.03815334
20purine nucleobase biosynthetic process (GO:0009113)4.01250971
21telomere maintenance via recombination (GO:0000722)4.00778581
22ribonucleoprotein complex biogenesis (GO:0022613)3.99664375
23CENP-A containing nucleosome assembly (GO:0034080)3.99262234
24proteasome assembly (GO:0043248)3.98123852
25IMP biosynthetic process (GO:0006188)3.94303062
26translational termination (GO:0006415)3.92465015
27viral transcription (GO:0019083)3.91200516
28ribosomal small subunit biogenesis (GO:0042274)3.90936957
29mitotic recombination (GO:0006312)3.82004598
30establishment of integrated proviral latency (GO:0075713)3.81573995
31DNA replication-dependent nucleosome assembly (GO:0006335)3.78177990
32DNA replication-dependent nucleosome organization (GO:0034723)3.78177990
33spliceosomal snRNP assembly (GO:0000387)3.77857504
34folic acid-containing compound biosynthetic process (GO:0009396)3.76470187
35negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.69924548
36telomere maintenance via telomere lengthening (GO:0010833)3.67545822
37mitotic metaphase plate congression (GO:0007080)3.67340183
38regulation of mitochondrial translation (GO:0070129)3.65314557
39cullin deneddylation (GO:0010388)3.65202683
40translational elongation (GO:0006414)3.64702257
41rRNA processing (GO:0006364)3.64174534
42mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.63600437
43translational initiation (GO:0006413)3.62647187
44DNA replication-independent nucleosome organization (GO:0034724)3.59166375
45DNA replication-independent nucleosome assembly (GO:0006336)3.59166375
46mitotic sister chromatid segregation (GO:0000070)3.58144213
47protein localization to kinetochore (GO:0034501)3.56904418
48IMP metabolic process (GO:0046040)3.55714735
49nucleotide-excision repair, DNA gap filling (GO:0006297)3.54839505
50DNA double-strand break processing (GO:0000729)3.53738492
51rRNA metabolic process (GO:0016072)3.51812356
52regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.51454004
53anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.50835257
54positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.50103573
55respiratory electron transport chain (GO:0022904)3.49845259
56mitotic nuclear envelope disassembly (GO:0007077)3.47932979
57protein deneddylation (GO:0000338)3.46907599
58oxidative phosphorylation (GO:0006119)3.46808590
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.45712883
60pseudouridine synthesis (GO:0001522)3.45473340
61positive regulation of ligase activity (GO:0051351)3.45254255
62SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.44549515
63kinetochore organization (GO:0051383)3.42070783
64nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.41448758
65electron transport chain (GO:0022900)3.40486248
66establishment of viral latency (GO:0019043)3.40355869
67establishment of protein localization to mitochondrial membrane (GO:0090151)3.40067020
68cotranslational protein targeting to membrane (GO:0006613)3.38825318
69transcription-coupled nucleotide-excision repair (GO:0006283)3.37329282
70DNA ligation (GO:0006266)3.37252188
71nuclear pore organization (GO:0006999)3.37040808
72regulation of ubiquitin-protein transferase activity (GO:0051438)3.36474129
73histone exchange (GO:0043486)3.36090121
74negative regulation of ligase activity (GO:0051352)3.35966203
75negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.35966203
76protein targeting to ER (GO:0045047)3.35427543
77nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.33358065
78DNA damage response, detection of DNA damage (GO:0042769)3.31072701
79non-recombinational repair (GO:0000726)3.30666536
80double-strand break repair via nonhomologous end joining (GO:0006303)3.30666536
81protein targeting to mitochondrion (GO:0006626)3.29916401
82mitochondrial respiratory chain complex assembly (GO:0033108)3.28856374
83spliceosomal complex assembly (GO:0000245)3.27819778
84regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.27475125
85regulation of mitotic spindle checkpoint (GO:1903504)3.27475125
86viral mRNA export from host cell nucleus (GO:0046784)3.26364669
87metaphase plate congression (GO:0051310)3.25126182
88regulation of ligase activity (GO:0051340)3.24635175
89sister chromatid segregation (GO:0000819)3.23683014
90translation (GO:0006412)3.23441056
91nuclear envelope disassembly (GO:0051081)3.23261833
92membrane disassembly (GO:0030397)3.23261833
93cell cycle G1/S phase transition (GO:0044843)3.22955223
94G1/S transition of mitotic cell cycle (GO:0000082)3.22955223
95rRNA modification (GO:0000154)3.21550942
96attachment of spindle microtubules to kinetochore (GO:0008608)3.21136912
97cellular protein complex disassembly (GO:0043624)3.20202325
98protein complex biogenesis (GO:0070271)3.19678052
99cellular component biogenesis (GO:0044085)3.19236487
100protein localization to mitochondrion (GO:0070585)3.18749767
101protein localization to endoplasmic reticulum (GO:0070972)3.18346386
102establishment of protein localization to endoplasmic reticulum (GO:0072599)3.16942213
103DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.15887811
104DNA catabolic process, exonucleolytic (GO:0000738)3.13839794
105transcription elongation from RNA polymerase III promoter (GO:0006385)3.13670611
106termination of RNA polymerase III transcription (GO:0006386)3.13670611
107kinetochore assembly (GO:0051382)3.13194628
1087-methylguanosine mRNA capping (GO:0006370)3.13098594
109deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.12892981
110signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.12481785
111intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.12481785
112positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.11371413
113viral life cycle (GO:0019058)3.11304788
114establishment of protein localization to mitochondrion (GO:0072655)3.09477617
115regulation of helicase activity (GO:0051095)3.09391973
116signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.09197780
117signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.09197780
118signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.09197780
119regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.08812085
120somatic diversification of immune receptors via somatic mutation (GO:0002566)3.08791514
121somatic hypermutation of immunoglobulin genes (GO:0016446)3.08791514
122RNA capping (GO:0036260)3.08363993
1237-methylguanosine RNA capping (GO:0009452)3.08363993
124spindle checkpoint (GO:0031577)3.07954474
125histone mRNA metabolic process (GO:0008334)3.07941850
126mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.07764047
127mitochondrial respiratory chain complex I assembly (GO:0032981)3.07764047
128NADH dehydrogenase complex assembly (GO:0010257)3.07764047
129maturation of 5.8S rRNA (GO:0000460)3.07737903
130signal transduction involved in DNA integrity checkpoint (GO:0072401)3.07300736
131signal transduction involved in DNA damage checkpoint (GO:0072422)3.07300736
132regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.06908413
133regulation of cellular amino acid metabolic process (GO:0006521)3.06373946
134nuclear pore complex assembly (GO:0051292)3.06076958
135respiratory chain complex IV assembly (GO:0008535)3.05986103
136negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.04823315
137negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.04823315
138negative regulation of mitotic sister chromatid segregation (GO:0033048)3.04823315
139negative regulation of mitotic sister chromatid separation (GO:2000816)3.04823315
140negative regulation of sister chromatid segregation (GO:0033046)3.04823315
141deoxyribonucleotide biosynthetic process (GO:0009263)3.04012992
142signal transduction involved in cell cycle checkpoint (GO:0072395)3.02800283

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.02229776
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.87303786
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.00650330
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.74105690
5* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.61241638
6* EST1_17652178_ChIP-ChIP_JURKAT_Human3.33529923
7* GABP_17652178_ChIP-ChIP_JURKAT_Human3.32964526
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.26053866
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.19363214
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.16446760
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.14278241
12MYC_18358816_ChIP-ChIP_MESCs_Mouse3.13621835
13* ETS1_20019798_ChIP-Seq_JURKAT_Human3.10346281
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.98753789
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.94079549
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.81801987
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.64086326
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.57037019
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.55877425
20XRN2_22483619_ChIP-Seq_HELA_Human2.52064344
21VDR_23849224_ChIP-Seq_CD4+_Human2.47049122
22* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.27921520
23DCP1A_22483619_ChIP-Seq_HELA_Human2.27441109
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.21699759
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18365167
26FOXP3_21729870_ChIP-Seq_TREG_Human2.12052737
27* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.11164665
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07105694
29TTF2_22483619_ChIP-Seq_HELA_Human2.04089934
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03143969
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.02231217
32GABP_19822575_ChIP-Seq_HepG2_Human2.01895359
33* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.99590377
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.98291601
35* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97260608
36AR_21909140_ChIP-Seq_LNCAP_Human1.93508127
37ELK1_19687146_ChIP-ChIP_HELA_Human1.91559446
38* E2F1_21310950_ChIP-Seq_MCF-7_Human1.89016158
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.84893576
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.79896455
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.77927476
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77566474
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.77556085
44* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.77193502
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.76158135
46* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72370395
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70670126
48* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64536682
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59619903
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.58261959
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58209120
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53306366
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.45855741
54CIITA_25753668_ChIP-Seq_RAJI_Human1.42923086
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.42079557
56KDM5A_27292631_Chip-Seq_BREAST_Human1.39777050
57* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32131311
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29266739
59* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28101537
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27482758
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27057018
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23400847
63* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21993213
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21736856
65SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.20919868
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20771266
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19236995
68* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16334406
69EWS_26573619_Chip-Seq_HEK293_Human1.15697048
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15663137
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14813196
72TFEB_21752829_ChIP-Seq_HELA_Human1.12656283
73* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10830252
74ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09199320
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.08906542
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07059147
77* MYC_18940864_ChIP-ChIP_HL60_Human1.06305589
78* CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05011656
79* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04322076
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04144511
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.02888331
82FUS_26573619_Chip-Seq_HEK293_Human1.02351216
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01803675
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01146298
85* ELK1_22589737_ChIP-Seq_MCF10A_Human1.00338289
86NANOG_16153702_ChIP-ChIP_HESCs_Human0.98158349
87* MYC_22102868_ChIP-Seq_BL_Human0.96999001
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95237178
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93912487
90POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93388546
91SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91209519
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90805876
93CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90437306
94PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89860640
95SOX2_16153702_ChIP-ChIP_HESCs_Human0.89008771
96SOX17_20123909_ChIP-Seq_XEN_Mouse0.86998807
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.86987463
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.86366150
99KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.85776165
100KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.85776165
101KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85776165
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84979237
103* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84681007
104ZNF274_21170338_ChIP-Seq_K562_Hela0.82407735
105* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81914885
106FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81841511
107TP63_19390658_ChIP-ChIP_HaCaT_Human0.80619101
108IRF1_19129219_ChIP-ChIP_H3396_Human0.80210764
109* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80186516
110CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.79985879
111ESR1_15608294_ChIP-ChIP_MCF-7_Human0.79558910
112* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.79366349
113* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79192362
114* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77848279
115VDR_22108803_ChIP-Seq_LS180_Human0.74460742
116CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.71686614
117* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.69105897
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.65885328
119RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.61135370
120ELF5_23300383_ChIP-Seq_T47D_Human0.60833539

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.80976526
2MP0004957_abnormal_blastocyst_morpholog5.15832341
3MP0010094_abnormal_chromosome_stability5.07902018
4MP0003111_abnormal_nucleus_morphology4.38131279
5MP0008057_abnormal_DNA_replication4.18082615
6* MP0003077_abnormal_cell_cycle4.07791014
7MP0008058_abnormal_DNA_repair4.03720356
8MP0003123_paternal_imprinting3.90535088
9MP0008932_abnormal_embryonic_tissue3.17148953
10MP0008007_abnormal_cellular_replicative3.08301761
11MP0008877_abnormal_DNA_methylation2.64868204
12MP0003786_premature_aging2.50462530
13MP0001730_embryonic_growth_arrest2.45870017
14* MP0000350_abnormal_cell_proliferation2.23801337
15MP0003806_abnormal_nucleotide_metabolis2.14742557
16MP0003121_genomic_imprinting1.97807756
17MP0002396_abnormal_hematopoietic_system1.94612343
18MP0010352_gastrointestinal_tract_polyps1.79821039
19MP0009379_abnormal_foot_pigmentation1.79487181
20MP0001697_abnormal_embryo_size1.76414399
21MP0000372_irregular_coat_pigmentation1.72747818
22MP0010307_abnormal_tumor_latency1.72461987
23MP0002080_prenatal_lethality1.64351694
24MP0002102_abnormal_ear_morphology1.60746755
25MP0003718_maternal_effect1.57932518
26MP0005380_embryogenesis_phenotype1.56544851
27MP0001672_abnormal_embryogenesis/_devel1.56544851
28MP0000490_abnormal_crypts_of1.52213492
29MP0002210_abnormal_sex_determination1.50786729
30MP0002085_abnormal_embryonic_tissue1.48775725
31MP0000313_abnormal_cell_death1.47659447
32MP0004133_heterotaxia1.44997271
33MP0004147_increased_porphyrin_level1.43426370
34MP0002084_abnormal_developmental_patter1.43296794
35MP0003890_abnormal_embryonic-extraembry1.43056633
36MP0006292_abnormal_olfactory_placode1.40722123
37MP0003984_embryonic_growth_retardation1.36737026
38MP0006036_abnormal_mitochondrial_physio1.35838638
39MP0001145_abnormal_male_reproductive1.34920062
40MP0002160_abnormal_reproductive_system1.33139087
41MP0002019_abnormal_tumor_incidence1.33018269
42MP0002088_abnormal_embryonic_growth/wei1.32758726
43MP0000358_abnormal_cell_content/1.32168859
44MP0003567_abnormal_fetal_cardiomyocyte1.31770427
45MP0003136_yellow_coat_color1.28067456
46MP0006035_abnormal_mitochondrial_morpho1.27264496
47MP0004197_abnormal_fetal_growth/weight/1.25316016
48MP0001293_anophthalmia1.24871685
49MP0003186_abnormal_redox_activity1.21010216
50MP0002736_abnormal_nociception_after1.19251229
51MP0002086_abnormal_extraembryonic_tissu1.18678386
52MP0003315_abnormal_perineum_morphology1.17149817
53MP0009333_abnormal_splenocyte_physiolog1.15882520
54MP0001529_abnormal_vocalization1.15267140
55MP0001929_abnormal_gametogenesis1.14472141
56MP0000537_abnormal_urethra_morphology1.13607616
57MP0000653_abnormal_sex_gland1.11227067
58MP0003880_abnormal_central_pattern1.10084960
59MP0003221_abnormal_cardiomyocyte_apopto1.09369370
60MP0004808_abnormal_hematopoietic_stem1.07334688
61MP0010030_abnormal_orbit_morphology1.06446834
62MP0005389_reproductive_system_phenotype0.97344182
63MP0002751_abnormal_autonomic_nervous0.96406635
64MP0003119_abnormal_digestive_system0.94394262
65MP0008995_early_reproductive_senescence0.94166408
66MP0003122_maternal_imprinting0.93577791
67MP0005266_abnormal_metabolism0.91576051
68MP0001188_hyperpigmentation0.86981420
69MP0005408_hypopigmentation0.86590990
70MP0001764_abnormal_homeostasis0.85761775
71MP0005384_cellular_phenotype0.85125512
72MP0004215_abnormal_myocardial_fiber0.84990352
73MP0005253_abnormal_eye_physiology0.84864330
74MP0008875_abnormal_xenobiotic_pharmacok0.82561807
75MP0009046_muscle_twitch0.80552648
76MP0002938_white_spotting0.78083601
77MP0003941_abnormal_skin_development0.77634667
78MP0005084_abnormal_gallbladder_morpholo0.77327049
79* MP0000703_abnormal_thymus_morphology0.76946431
80MP0009697_abnormal_copulation0.76314706
81MP0001119_abnormal_female_reproductive0.73833608
82MP0003698_abnormal_male_reproductive0.72347190
83MP0000858_altered_metastatic_potential0.72128993
84MP0006054_spinal_hemorrhage0.71210248
85MP0009672_abnormal_birth_weight0.70833703
86MP0005075_abnormal_melanosome_morpholog0.70807754
87MP0000647_abnormal_sebaceous_gland0.70031283
88* MP0002398_abnormal_bone_marrow0.68251819
89MP0001545_abnormal_hematopoietic_system0.67007108
90MP0005397_hematopoietic_system_phenotyp0.67007108
91MP0001905_abnormal_dopamine_level0.66695798
92MP0002090_abnormal_vision0.66074065
93MP0001919_abnormal_reproductive_system0.65700826
94* MP0002722_abnormal_immune_system0.65227609
95MP0004233_abnormal_muscle_weight0.63902894
96MP0001727_abnormal_embryo_implantation0.63652796
97MP0003763_abnormal_thymus_physiology0.63211207
98MP0000049_abnormal_middle_ear0.62882713
99MP0001881_abnormal_mammary_gland0.62353319
100MP0002234_abnormal_pharynx_morphology0.62321375
101* MP0000689_abnormal_spleen_morphology0.62062970
102MP0006072_abnormal_retinal_apoptosis0.61790900
103MP0001177_atelectasis0.61612802
104MP0002697_abnormal_eye_size0.60551433
105MP0005621_abnormal_cell_physiology0.60246396
106MP0008789_abnormal_olfactory_epithelium0.59926280
107MP0000631_abnormal_neuroendocrine_gland0.59914549
108MP0000749_muscle_degeneration0.59496344
109MP0002111_abnormal_tail_morphology0.59298773
110MP0003137_abnormal_impulse_conducting0.58794668
111MP0002075_abnormal_coat/hair_pigmentati0.58426817
112MP0002653_abnormal_ependyma_morphology0.57687480
113MP0005391_vision/eye_phenotype0.57038912
114MP0008872_abnormal_physiological_respon0.56786399
115MP0002638_abnormal_pupillary_reflex0.56367962
116MP0002161_abnormal_fertility/fecundity0.56345713
117MP0001485_abnormal_pinna_reflex0.56135764
118MP0001853_heart_inflammation0.55633368
119MP0005171_absent_coat_pigmentation0.55251654
120MP0002132_abnormal_respiratory_system0.54818592
121MP0002095_abnormal_skin_pigmentation0.54795030
122MP0009053_abnormal_anal_canal0.54687010
123MP0001186_pigmentation_phenotype0.53970172
124MP0001968_abnormal_touch/_nociception0.53889141
125* MP0002429_abnormal_blood_cell0.53033608
126MP0003861_abnormal_nervous_system0.51765879
127MP0001286_abnormal_eye_development0.49671283
128MP0009703_decreased_birth_body0.49552612
129MP0003937_abnormal_limbs/digits/tail_de0.48798392
130MP0005076_abnormal_cell_differentiation0.43095491
131MP0002114_abnormal_axial_skeleton0.42704239

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.09286734
2Abnormality of cells of the erythroid lineage (HP:0012130)4.50823419
3Reticulocytopenia (HP:0001896)4.23641503
4Abnormal number of erythroid precursors (HP:0012131)4.19559120
5Breast hypoplasia (HP:0003187)3.82273967
6Oral leukoplakia (HP:0002745)3.79727884
7Colon cancer (HP:0003003)3.60548231
8Cerebral edema (HP:0002181)3.50858515
9Abnormality of the anterior horn cell (HP:0006802)3.43674015
10Degeneration of anterior horn cells (HP:0002398)3.43674015
11Aplastic anemia (HP:0001915)3.39549566
12Cerebral hypomyelination (HP:0006808)3.31330004
13Abnormality of the labia minora (HP:0012880)3.30544505
14Medulloblastoma (HP:0002885)3.19024929
15Ependymoma (HP:0002888)3.12730678
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.10492372
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.10492372
18Carpal bone hypoplasia (HP:0001498)3.08201686
19Selective tooth agenesis (HP:0001592)3.07192815
20Chromsome breakage (HP:0040012)3.04901017
21Macrocytic anemia (HP:0001972)3.03814319
22Agnosia (HP:0010524)3.01598674
23Pallor (HP:0000980)2.89921046
24Acute necrotizing encephalopathy (HP:0006965)2.89581522
25Absent thumb (HP:0009777)2.89324933
26Lactic acidosis (HP:0003128)2.87362806
27Rough bone trabeculation (HP:0100670)2.86908943
28Abnormality of chromosome stability (HP:0003220)2.86067677
29Meckel diverticulum (HP:0002245)2.85307058
30Patellar aplasia (HP:0006443)2.84036592
31Abnormality of the preputium (HP:0100587)2.83542943
32Supernumerary spleens (HP:0009799)2.80698254
33Increased CSF lactate (HP:0002490)2.79674751
34Abnormal mitochondria in muscle tissue (HP:0008316)2.79464246
35Leukodystrophy (HP:0002415)2.79292958
36Renal Fanconi syndrome (HP:0001994)2.78793837
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.78045955
38Increased intramyocellular lipid droplets (HP:0012240)2.75230960
39Abnormality of the ileum (HP:0001549)2.72011482
40Increased serum lactate (HP:0002151)2.71604848
41Mitochondrial inheritance (HP:0001427)2.69575836
42Increased serum pyruvate (HP:0003542)2.68480420
43Abnormality of glycolysis (HP:0004366)2.68480420
44Microvesicular hepatic steatosis (HP:0001414)2.63794956
45Aplasia/Hypoplasia of the patella (HP:0006498)2.63759959
46Premature graying of hair (HP:0002216)2.61820840
4711 pairs of ribs (HP:0000878)2.59088754
48Respiratory failure (HP:0002878)2.57893137
49Hepatocellular necrosis (HP:0001404)2.55143919
503-Methylglutaconic aciduria (HP:0003535)2.54900660
51Microretrognathia (HP:0000308)2.53545128
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.49756631
53Increased hepatocellular lipid droplets (HP:0006565)2.48830654
54Rhabdomyosarcoma (HP:0002859)2.47886170
55Absent radius (HP:0003974)2.47342151
56Abnormality of methionine metabolism (HP:0010901)2.45409160
57Abnormal lung lobation (HP:0002101)2.43241768
58Horseshoe kidney (HP:0000085)2.42791563
59Abnormality of alanine metabolism (HP:0010916)2.40509803
60Neoplasm of the pancreas (HP:0002894)2.36401817
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.32937769
62Myelodysplasia (HP:0002863)2.32727510
63Atrophy/Degeneration involving motor neurons (HP:0007373)2.30621974
64Small intestinal stenosis (HP:0012848)2.30579604
65Duodenal stenosis (HP:0100867)2.30579604
66Aplasia involving forearm bones (HP:0009822)2.30318513
67Absent forearm bone (HP:0003953)2.30318513
68Trismus (HP:0000211)2.28774365
69Progressive macrocephaly (HP:0004481)2.27727691
70Abnormal protein glycosylation (HP:0012346)2.27142214
71Abnormal glycosylation (HP:0012345)2.27142214
72Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.27142214
73Abnormal protein N-linked glycosylation (HP:0012347)2.27142214
74Abnormal number of incisors (HP:0011064)2.24806718
75Reduced antithrombin III activity (HP:0001976)2.24414185
76Type I transferrin isoform profile (HP:0003642)2.22988318
77Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.21692498
78Exertional dyspnea (HP:0002875)2.20587990
79Postnatal microcephaly (HP:0005484)2.19140076
80Optic disc pallor (HP:0000543)2.19012649
81Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.18491402
82Bone marrow hypocellularity (HP:0005528)2.18415104
83Abnormality of serum amino acid levels (HP:0003112)2.16397394
84Respiratory difficulties (HP:0002880)2.14877239
85Lipid accumulation in hepatocytes (HP:0006561)2.14784625
86Acute encephalopathy (HP:0006846)2.12322524
87Lethargy (HP:0001254)2.12320298
88CNS hypomyelination (HP:0003429)2.11145741
89Increased muscle lipid content (HP:0009058)2.10859684
90Exercise intolerance (HP:0003546)2.09245998
91Basal cell carcinoma (HP:0002671)2.08277209
92Sloping forehead (HP:0000340)2.08119129
93Triphalangeal thumb (HP:0001199)2.07240313
94Shoulder girdle muscle weakness (HP:0003547)2.06788484
95Abnormal trabecular bone morphology (HP:0100671)2.04592003
96Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04119404
97Cellular immunodeficiency (HP:0005374)2.03610187
98Nephroblastoma (Wilms tumor) (HP:0002667)2.03142927
99Hepatic necrosis (HP:0002605)2.02668673
100Megaloblastic anemia (HP:0001889)2.02524432
101Cleft eyelid (HP:0000625)2.00852459
102Tracheoesophageal fistula (HP:0002575)2.00712353
103Methylmalonic acidemia (HP:0002912)1.99902885
104Multiple enchondromatosis (HP:0005701)1.99080356
105Missing ribs (HP:0000921)1.98981227
106Pancytopenia (HP:0001876)1.97855019
107Abnormality of abdominal situs (HP:0011620)1.97325765
108Abdominal situs inversus (HP:0003363)1.97325765
109Premature ovarian failure (HP:0008209)1.96097628
110Abnormality of aspartate family amino acid metabolism (HP:0010899)1.95374106
111Glossoptosis (HP:0000162)1.94806071
112Embryonal renal neoplasm (HP:0011794)1.94615641
113Atresia of the external auditory canal (HP:0000413)1.93690830
114Neoplasm of the colon (HP:0100273)1.91830678
115CNS demyelination (HP:0007305)1.90844153
116Poor head control (HP:0002421)1.90219717
117Amaurosis fugax (HP:0100576)1.89633966
118Congenital, generalized hypertrichosis (HP:0004540)1.89458551
119Abnormality of the duodenum (HP:0002246)1.89227264
120Impulsivity (HP:0100710)1.88546196
121Stenosis of the external auditory canal (HP:0000402)1.88434221
122Pelvic girdle muscle weakness (HP:0003749)1.88244653
123Volvulus (HP:0002580)1.88059647
124Angiofibromas (HP:0010615)1.87660887
125Adenoma sebaceum (HP:0009720)1.87660887
126Facial cleft (HP:0002006)1.87624367
127Testicular atrophy (HP:0000029)1.87544288
128Emotional lability (HP:0000712)1.87393031
129Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86682379
130Hyperalaninemia (HP:0003348)1.86682379
131Abnormality of placental membranes (HP:0011409)1.84406846
132Amniotic constriction ring (HP:0009775)1.84406846
133Abnormality of the carotid arteries (HP:0005344)1.83807907
134Hypoplasia of the pons (HP:0012110)1.75800588
135Abnormality of the pons (HP:0007361)1.75146929
136Neoplasm of the adrenal gland (HP:0100631)1.73297350
137Methylmalonic aciduria (HP:0012120)1.73237970
138Hyperglycinemia (HP:0002154)1.70437451
139X-linked dominant inheritance (HP:0001423)1.68635121
140Glioma (HP:0009733)1.68243102
141Increased nuchal translucency (HP:0010880)1.67097949

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.85938707
2WEE14.53053003
3EIF2AK14.09985014
4CDC73.94764944
5VRK23.07746428
6SRPK12.87641760
7TSSK62.77554661
8EIF2AK32.75314255
9STK162.59463670
10BRSK22.52429928
11ACVR1B2.37466512
12NEK12.35911435
13NME22.31301458
14TESK22.22911317
15VRK12.13907766
16PLK11.95068178
17NEK21.92033636
18TTK1.91247185
19SCYL21.81082723
20MKNK11.79439672
21PLK41.78942609
22PLK31.73070420
23TRIM281.71466043
24TLK11.70901682
25BRSK11.61194120
26PASK1.56858138
27DYRK31.54114163
28ATR1.53269196
29PNCK1.51131338
30AURKB1.42941421
31CDK71.41604265
32NUAK11.39241128
33RPS6KB21.38938299
34AURKA1.38299870
35MKNK21.37735228
36PBK1.27218084
37CCNB11.23864838
38RPS6KA41.21285136
39NME11.21097225
40CHEK21.19929813
41TAF11.19737014
42TESK11.13398510
43MAP3K81.05930952
44BMPR1B1.05156078
45TGFBR11.04590803
46CHEK11.02839912
47BRAF0.98674052
48LIMK10.98351175
49WNK30.96835586
50CDK80.96717593
51PIM20.96150126
52FLT30.93892967
53MAP4K20.91402631
54CSNK2A20.85582930
55PAK40.85581040
56CSNK1G10.83588849
57MAPKAPK50.79391330
58CSNK2A10.79215217
59ATM0.78235082
60CDK40.78030714
61EPHA20.77673916
62CSNK1G20.77395855
63EIF2AK20.74491388
64TNIK0.73916049
65MAP3K110.71818964
66DYRK20.71148599
67CDK20.69941137
68CSNK1A1L0.68185971
69PDK30.67249125
70PDK40.67249125
71MST40.64488070
72PAK10.63062873
73ZAK0.60687398
74MAP3K120.59601076
75MINK10.58468219
76ALK0.55756948
77KDR0.53886208
78CDK10.51878571
79STK40.51643459
80PRKCI0.51589599
81CDK30.51372817
82ERBB40.51111745
83CSNK1G30.51009932
84RPS6KA50.50948943
85MAPKAPK30.48364090
86DAPK10.48009717
87CLK10.46555212
88CDK120.45866206
89PIM10.44441361
90STK100.41718852
91ERBB30.40213410
92CSNK1E0.39382747
93CDK140.38572857
94YES10.37083155
95ABL20.35730263
96ARAF0.35411421
97CDK190.34809815
98MAP2K70.34478026
99BRD40.33319038
100PLK20.31904390
101PRKDC0.30762507
102BCKDK0.30225671
103BCR0.28761017
104STK30.28675476
105CDK180.27759883
106TAOK20.27574576
107CDK11A0.27449399
108TEC0.27144166
109MAP3K50.27143725
110MELK0.26543376
111PRKCG0.26251731
112UHMK10.26110185
113OXSR10.25473522
114CDK150.25380468
115PDK20.24704113
116ILK0.24211866
117TIE10.23977220
118LRRK20.22639270
119RAF10.22453102
120STK38L0.21607475
121AKT20.21090322
122MARK30.20443409

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.93294012
2Mismatch repair_Homo sapiens_hsa034304.30956827
3Proteasome_Homo sapiens_hsa030504.21995174
4Ribosome_Homo sapiens_hsa030103.97459423
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.88831738
6RNA polymerase_Homo sapiens_hsa030203.54927124
7Spliceosome_Homo sapiens_hsa030403.43812587
8RNA transport_Homo sapiens_hsa030133.11857607
9Nucleotide excision repair_Homo sapiens_hsa034202.99838479
10Homologous recombination_Homo sapiens_hsa034402.89503048
11Base excision repair_Homo sapiens_hsa034102.85614485
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.72684534
13Pyrimidine metabolism_Homo sapiens_hsa002402.64526045
14One carbon pool by folate_Homo sapiens_hsa006702.50242502
15Cell cycle_Homo sapiens_hsa041102.39985392
16Basal transcription factors_Homo sapiens_hsa030222.07759660
17Non-homologous end-joining_Homo sapiens_hsa034502.05935711
18Fanconi anemia pathway_Homo sapiens_hsa034602.00298413
19RNA degradation_Homo sapiens_hsa030181.89646670
20Parkinsons disease_Homo sapiens_hsa050121.64805219
21mRNA surveillance pathway_Homo sapiens_hsa030151.63981379
22Oxidative phosphorylation_Homo sapiens_hsa001901.53776356
23Purine metabolism_Homo sapiens_hsa002301.48610059
24Protein export_Homo sapiens_hsa030601.48456082
25Huntingtons disease_Homo sapiens_hsa050161.43452111
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39359898
27Propanoate metabolism_Homo sapiens_hsa006401.28506901
28p53 signaling pathway_Homo sapiens_hsa041151.22958390
29Fatty acid elongation_Homo sapiens_hsa000621.21492998
30Epstein-Barr virus infection_Homo sapiens_hsa051691.18974854
31Oocyte meiosis_Homo sapiens_hsa041141.07628212
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07566484
33Systemic lupus erythematosus_Homo sapiens_hsa053221.07536030
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03103357
35Caffeine metabolism_Homo sapiens_hsa002320.95442013
36Steroid biosynthesis_Homo sapiens_hsa001000.92813273
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90296460
38Folate biosynthesis_Homo sapiens_hsa007900.89974341
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86250138
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84012965
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.83524733
42Antigen processing and presentation_Homo sapiens_hsa046120.81959386
43Alzheimers disease_Homo sapiens_hsa050100.80416905
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77147212
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.74079999
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72813490
47Viral carcinogenesis_Homo sapiens_hsa052030.71513055
48Biosynthesis of amino acids_Homo sapiens_hsa012300.71393422
49Thyroid cancer_Homo sapiens_hsa052160.70447014
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68164967
51Pentose phosphate pathway_Homo sapiens_hsa000300.65897584
52Herpes simplex infection_Homo sapiens_hsa051680.64705919
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63483694
54Alcoholism_Homo sapiens_hsa050340.59949681
55Legionellosis_Homo sapiens_hsa051340.54427462
56Glutathione metabolism_Homo sapiens_hsa004800.52772516
57Selenocompound metabolism_Homo sapiens_hsa004500.51642781
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.50187111
59Carbon metabolism_Homo sapiens_hsa012000.50000014
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48419428
61N-Glycan biosynthesis_Homo sapiens_hsa005100.47238158
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46976943
63HTLV-I infection_Homo sapiens_hsa051660.45226583
64Sulfur relay system_Homo sapiens_hsa041220.45108541
65Sulfur metabolism_Homo sapiens_hsa009200.43791000
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43696111
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42528700
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41720768
69Butanoate metabolism_Homo sapiens_hsa006500.41026402
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38249501
71Peroxisome_Homo sapiens_hsa041460.37878395
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36715317
73Fatty acid metabolism_Homo sapiens_hsa012120.34219252
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33075424
75Collecting duct acid secretion_Homo sapiens_hsa049660.32567409
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32140021
77beta-Alanine metabolism_Homo sapiens_hsa004100.31961015
78Metabolic pathways_Homo sapiens_hsa011000.31177158
79Phototransduction_Homo sapiens_hsa047440.30348664
80Type I diabetes mellitus_Homo sapiens_hsa049400.30236560
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30104232
82Nitrogen metabolism_Homo sapiens_hsa009100.29836013
83Cardiac muscle contraction_Homo sapiens_hsa042600.27910251
84Tryptophan metabolism_Homo sapiens_hsa003800.24755381
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24650460
86Regulation of autophagy_Homo sapiens_hsa041400.21322785
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21211126
88Galactose metabolism_Homo sapiens_hsa000520.21101348
89Shigellosis_Homo sapiens_hsa051310.20212123
90Colorectal cancer_Homo sapiens_hsa052100.20050301
91MicroRNAs in cancer_Homo sapiens_hsa052060.16612252
92Renin-angiotensin system_Homo sapiens_hsa046140.16458387
93Fructose and mannose metabolism_Homo sapiens_hsa000510.15598919
94Nicotine addiction_Homo sapiens_hsa050330.15528963
95Apoptosis_Homo sapiens_hsa042100.15116614
96Fatty acid degradation_Homo sapiens_hsa000710.14474557
97TGF-beta signaling pathway_Homo sapiens_hsa043500.13627757
98Vibrio cholerae infection_Homo sapiens_hsa051100.13408021
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.13155666
100Pyruvate metabolism_Homo sapiens_hsa006200.11651121
101Asthma_Homo sapiens_hsa053100.11616714
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.11253467
103HIF-1 signaling pathway_Homo sapiens_hsa040660.10944805
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.10911150
105Vitamin B6 metabolism_Homo sapiens_hsa007500.10697440
106Olfactory transduction_Homo sapiens_hsa047400.09756170
107Tyrosine metabolism_Homo sapiens_hsa003500.09100668
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.08925414
109Hippo signaling pathway_Homo sapiens_hsa043900.08564057
110Bladder cancer_Homo sapiens_hsa052190.08124239
111Primary immunodeficiency_Homo sapiens_hsa053400.08096761
112Hepatitis B_Homo sapiens_hsa051610.07654212
113Chemical carcinogenesis_Homo sapiens_hsa052040.07167007
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.06095441
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.05032777
116Allograft rejection_Homo sapiens_hsa053300.04998346
117Measles_Homo sapiens_hsa051620.03411831
118Small cell lung cancer_Homo sapiens_hsa052220.02944108
119Arachidonic acid metabolism_Homo sapiens_hsa005900.02587604
120Influenza A_Homo sapiens_hsa051640.01637063
121Pathways in cancer_Homo sapiens_hsa052000.01395264
122Viral myocarditis_Homo sapiens_hsa054160.00314799
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.00087273
124Drug metabolism - cytochrome P450_Homo sapiens_hsa00982-0.0388617
125SNARE interactions in vesicular transport_Homo sapiens_hsa04130-0.0114687
126Arginine and proline metabolism_Homo sapiens_hsa00330-0.0113971
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.0102438
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.0099756
129Ascorbate and aldarate metabolism_Homo sapiens_hsa00053-0.0078823
130Melanoma_Homo sapiens_hsa05218-0.0007292

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