CACYBPP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)5.93301873
2positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)5.93301873
3regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033395.75481232
4negative regulation of metanephros development (GO:0072217)5.46957300
5peptidyl-histidine modification (GO:0018202)5.14101048
6regulation of interleukin-12 biosynthetic process (GO:0045075)5.02448326
7regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.98725967
8regulation of podosome assembly (GO:0071801)4.71455600
9positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.63834431
10negative regulation of interleukin-17 production (GO:0032700)4.34714840
11regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.26547667
12regulation of MHC class II biosynthetic process (GO:0045346)4.16839180
13centriole replication (GO:0007099)4.13797987
14positive regulation of interleukin-1 beta secretion (GO:0050718)4.00128360
15regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.97474970
16positive regulation of interleukin-1 secretion (GO:0050716)3.81816059
17positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.80359954
18regulation of interleukin-6 biosynthetic process (GO:0045408)3.78377205
19regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.76181007
20regulation of isotype switching to IgG isotypes (GO:0048302)3.75474506
21organelle disassembly (GO:1903008)3.70219649
22resolution of meiotic recombination intermediates (GO:0000712)3.67669003
23proteasome assembly (GO:0043248)3.65138960
24regulation of interleukin-1 beta secretion (GO:0050706)3.64053209
25rRNA modification (GO:0000154)3.63086262
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.57502913
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.57502913
28NADH dehydrogenase complex assembly (GO:0010257)3.57502913
29regulation of vitamin D biosynthetic process (GO:0060556)3.56035693
30purine nucleobase biosynthetic process (GO:0009113)3.46989668
31cullin deneddylation (GO:0010388)3.45821156
32ether lipid metabolic process (GO:0046485)3.39919018
33ribonucleoprotein complex disassembly (GO:0032988)3.39214598
34negative regulation of neurological system process (GO:0031645)3.33929264
35DNA damage response, detection of DNA damage (GO:0042769)3.31506241
36rRNA methylation (GO:0031167)3.30181254
37respiratory chain complex IV assembly (GO:0008535)3.28361352
38regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.27445164
39exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.21897209
40microtubule polymerization or depolymerization (GO:0031109)3.20155709
41positive regulation of osteoclast differentiation (GO:0045672)3.20087247
42negative regulation of growth of symbiont in host (GO:0044130)3.18418081
43negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.18418081
44modulation of growth of symbiont involved in interaction with host (GO:0044144)3.18418081
45regulation of growth of symbiont in host (GO:0044126)3.18418081
46somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.17812005
47somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.17812005
48isotype switching (GO:0045190)3.17812005
49positive regulation of interleukin-1 beta production (GO:0032731)3.17153606
50establishment of protein localization to mitochondrial membrane (GO:0090151)3.16932562
51positive regulation of chemokine biosynthetic process (GO:0045080)3.15708569
52regulation of interleukin-1 secretion (GO:0050704)3.15534898
53cellular response to gamma radiation (GO:0071480)3.13843527
54RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.11668877
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.11668877
56intra-S DNA damage checkpoint (GO:0031573)3.10673984
57negative regulation of DNA-dependent DNA replication (GO:2000104)3.10668857
58nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.09178338
59regulation of cellular amino acid metabolic process (GO:0006521)3.06634937
60regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.04265752
61nucleobase biosynthetic process (GO:0046112)3.02697300
62replication fork processing (GO:0031297)3.01607134
63positive regulation of muscle cell apoptotic process (GO:0010661)3.01214711
64protein complex biogenesis (GO:0070271)3.01154993
65negative regulation of kidney development (GO:0090185)2.98422257
66protein deneddylation (GO:0000338)2.97970836
67regulation of cytokine production involved in inflammatory response (GO:1900015)2.97580484
68regulation of smooth muscle cell apoptotic process (GO:0034391)2.97005552
69CENP-A containing nucleosome assembly (GO:0034080)2.95868575
70DNA double-strand break processing (GO:0000729)2.95750600
71regulation of interleukin-17 production (GO:0032660)2.95438413
72pseudouridine synthesis (GO:0001522)2.95411788
73DNA topological change (GO:0006265)2.95034736
74DNA ligation (GO:0006266)2.92141748
75T cell differentiation involved in immune response (GO:0002292)2.91903117
76alpha-beta T cell differentiation involved in immune response (GO:0002293)2.91903117
77alpha-beta T cell activation involved in immune response (GO:0002287)2.91903117
78reciprocal meiotic recombination (GO:0007131)2.91334540
79reciprocal DNA recombination (GO:0035825)2.91334540
80positive regulation of phosphatase activity (GO:0010922)2.90880269
81signal peptide processing (GO:0006465)2.87844800
82protein prenylation (GO:0018342)2.87567897
83prenylation (GO:0097354)2.87567897
84signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.87503620
85signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.87503620
86signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.87503620
87DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.86641914
88chromatin remodeling at centromere (GO:0031055)2.85615029
89mitochondrial respiratory chain complex assembly (GO:0033108)2.84382208
90positive regulation of isotype switching (GO:0045830)2.80743460
91positive regulation of interleukin-1 production (GO:0032732)2.80629926
92histone exchange (GO:0043486)2.80433804
93signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.79419287
94intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.79419287
95defense response to protozoan (GO:0042832)2.79387961
96RNA-dependent DNA replication (GO:0006278)2.78640164
97regulation of response to interferon-gamma (GO:0060330)2.77819230
98positive regulation of DNA recombination (GO:0045911)2.76263351
99positive regulation of interleukin-12 production (GO:0032735)2.75687763
100positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)2.74505560

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.59671493
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.38072347
3VDR_22108803_ChIP-Seq_LS180_Human3.13086646
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.07560066
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.01451188
6TAF15_26573619_Chip-Seq_HEK293_Human2.85808189
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.84087959
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.74736584
9ELK1_19687146_ChIP-ChIP_HELA_Human2.56130621
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.46210982
11EWS_26573619_Chip-Seq_HEK293_Human2.45823803
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.43956846
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.38237985
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.35597177
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.33012852
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.16716844
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.11060785
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02290617
19FUS_26573619_Chip-Seq_HEK293_Human1.99565101
20IGF1R_20145208_ChIP-Seq_DFB_Human1.98748718
21GATA1_22025678_ChIP-Seq_K562_Human1.94665713
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.93099617
23ZNF274_21170338_ChIP-Seq_K562_Hela1.89548165
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88915917
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86940181
26VDR_23849224_ChIP-Seq_CD4+_Human1.86787917
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.80505738
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.71305575
29P300_19829295_ChIP-Seq_ESCs_Human1.70263169
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.64712651
31ER_23166858_ChIP-Seq_MCF-7_Human1.60343081
32PADI4_21655091_ChIP-ChIP_MCF-7_Human1.57763999
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57368968
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52636703
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49082356
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.48841182
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.47182288
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46499727
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42809392
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42219534
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41153245
42FOXP3_21729870_ChIP-Seq_TREG_Human1.40628558
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.39432583
44SALL4_22934838_ChIP-ChIP_CD34+_Human1.38793163
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37310703
46GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34717659
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.33961246
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33373617
49IRF1_19129219_ChIP-ChIP_H3396_Human1.33304070
50GBX2_23144817_ChIP-Seq_PC3_Human1.33018597
51IRF8_21731497_ChIP-ChIP_J774_Mouse1.32152636
52KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32095656
53JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.29898704
54SOX2_19829295_ChIP-Seq_ESCs_Human1.27973735
55NANOG_19829295_ChIP-Seq_ESCs_Human1.27973735
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27274328
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25709069
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.25586160
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.25458135
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24292890
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23911041
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21415004
63MYC_18940864_ChIP-ChIP_HL60_Human1.21052954
64E2F1_18555785_Chip-Seq_ESCs_Mouse1.20237437
65AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19932338
66P53_22387025_ChIP-Seq_ESCs_Mouse1.19877139
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19351373
68MYC_18555785_ChIP-Seq_MESCs_Mouse1.19085247
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18306779
70CRX_20693478_ChIP-Seq_RETINA_Mouse1.17152814
71TCF4_22108803_ChIP-Seq_LS180_Human1.16972360
72FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16950816
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13470135
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12020070
75ETS1_20019798_ChIP-Seq_JURKAT_Human1.11997881
76STAT3_18555785_Chip-Seq_ESCs_Mouse1.11608835
77P300_18555785_Chip-Seq_ESCs_Mouse1.11579859
78EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11564128
79TP53_22573176_ChIP-Seq_HFKS_Human1.10939754
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10430876
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10264596
82SMAD4_21799915_ChIP-Seq_A2780_Human1.08549138
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.07533252
84SOX2_18555785_Chip-Seq_ESCs_Mouse1.07105898
85EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07080193
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05325904
87SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04942055
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04227603
89CMYC_18555785_Chip-Seq_ESCs_Mouse1.03542138
90KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.03033172
91OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02655036
92BP1_19119308_ChIP-ChIP_Hs578T_Human1.02536578
93FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02354683
94DCP1A_22483619_ChIP-Seq_HELA_Human1.02107733
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01103555
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.01103555
97CBP_20019798_ChIP-Seq_JUKART_Human0.99999681
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99999681
99SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98858987
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98736573

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.77096310
2MP0004782_abnormal_surfactant_physiolog4.07337921
3MP0000372_irregular_coat_pigmentation3.79044266
4MP0001873_stomach_inflammation3.71437303
5MP0001188_hyperpigmentation3.29383512
6MP0008961_abnormal_basal_metabolism2.98250472
7MP0005671_abnormal_response_to2.95417800
8MP0009785_altered_susceptibility_to2.67366074
9MP0000569_abnormal_digit_pigmentation2.54352030
10MP0004142_abnormal_muscle_tone2.34020039
11MP0010307_abnormal_tumor_latency2.27283183
12MP0005084_abnormal_gallbladder_morpholo2.17586199
13MP0002102_abnormal_ear_morphology2.16013027
14MP0002938_white_spotting2.10306011
15MP0002933_joint_inflammation2.07071465
16MP0002138_abnormal_hepatobiliary_system2.05589775
17MP0003890_abnormal_embryonic-extraembry1.95763284
18MP0009697_abnormal_copulation1.91288188
19MP0002396_abnormal_hematopoietic_system1.84415905
20MP0003186_abnormal_redox_activity1.81627796
21MP0003786_premature_aging1.76965517
22MP0008058_abnormal_DNA_repair1.75620349
23MP0002148_abnormal_hypersensitivity_rea1.65698951
24MP0005551_abnormal_eye_electrophysiolog1.65402253
25MP0002405_respiratory_system_inflammati1.62366191
26MP0006072_abnormal_retinal_apoptosis1.61391938
27MP0005410_abnormal_fertilization1.57038414
28MP0001800_abnormal_humoral_immune1.48848368
29MP0001529_abnormal_vocalization1.47304673
30MP0003077_abnormal_cell_cycle1.46651867
31MP0008877_abnormal_DNA_methylation1.45243681
32MP0005253_abnormal_eye_physiology1.42723349
33MP0003567_abnormal_fetal_cardiomyocyte1.42380929
34MP0001293_anophthalmia1.42345872
35MP0004957_abnormal_blastocyst_morpholog1.40996470
36MP0001324_abnormal_eye_pigmentation1.40685551
37MP0002876_abnormal_thyroid_physiology1.40081230
38MP0000685_abnormal_immune_system1.38344917
39MP0006292_abnormal_olfactory_placode1.31161135
40MP0004145_abnormal_muscle_electrophysio1.30649474
41MP0010094_abnormal_chromosome_stability1.25189202
42MP0003011_delayed_dark_adaptation1.22576211
43MP0000427_abnormal_hair_cycle1.21288034
44MP0006036_abnormal_mitochondrial_physio1.19742765
45MP0005000_abnormal_immune_tolerance1.18935814
46MP0008872_abnormal_physiological_respon1.16027064
47MP0008873_increased_physiological_sensi1.12445460
48MP0008875_abnormal_xenobiotic_pharmacok1.10590792
49MP0005174_abnormal_tail_pigmentation1.09614447
50MP0008569_lethality_at_weaning1.08130630
51MP0003880_abnormal_central_pattern1.07673439
52MP0000015_abnormal_ear_pigmentation1.06989072
53MP0000579_abnormal_nail_morphology1.04582832
54MP0002736_abnormal_nociception_after1.02952317
55MP0001853_heart_inflammation1.02652197
56MP0001984_abnormal_olfaction1.01889632
57MP0002928_abnormal_bile_duct0.96014130
58MP0003111_abnormal_nucleus_morphology0.91664595
59MP0002282_abnormal_trachea_morphology0.90531669
60MP0000749_muscle_degeneration0.89481178
61MP0001348_abnormal_lacrimal_gland0.89285947
62MP0001485_abnormal_pinna_reflex0.88528388
63MP0005379_endocrine/exocrine_gland_phen0.88179648
64MP0008057_abnormal_DNA_replication0.87495999
65MP0008932_abnormal_embryonic_tissue0.86753395
66MP0002751_abnormal_autonomic_nervous0.85890886
67MP0009333_abnormal_splenocyte_physiolog0.85158566
68MP0001790_abnormal_immune_system0.81547588
69MP0005387_immune_system_phenotype0.81547588
70MP0008007_abnormal_cellular_replicative0.79949141
71MP0005645_abnormal_hypothalamus_physiol0.79629475
72MP0004885_abnormal_endolymph0.79106344
73MP0003436_decreased_susceptibility_to0.78227546
74MP0003121_genomic_imprinting0.76376182
75MP0002166_altered_tumor_susceptibility0.76122467
76MP0001119_abnormal_female_reproductive0.76026800
77MP0003787_abnormal_imprinting0.75446278
78MP0002723_abnormal_immune_serum0.75351564
79MP0009764_decreased_sensitivity_to0.74201163
80MP0003252_abnormal_bile_duct0.73792737
81MP0010155_abnormal_intestine_physiology0.73506729
82MP0001929_abnormal_gametogenesis0.73325211
83MP0003941_abnormal_skin_development0.72337942
84MP0004084_abnormal_cardiac_muscle0.71705421
85MP0000653_abnormal_sex_gland0.70738738
86MP0009765_abnormal_xenobiotic_induced0.69380886
87MP0002452_abnormal_antigen_presenting0.67362853
88MP0001177_atelectasis0.67226587
89MP0000689_abnormal_spleen_morphology0.66411163
90MP0002210_abnormal_sex_determination0.65523098
91MP0002272_abnormal_nervous_system0.63445354
92MP0002420_abnormal_adaptive_immunity0.63339779
93MP0001501_abnormal_sleep_pattern0.63054791
94MP0009046_muscle_twitch0.62447307
95MP0003195_calcinosis0.62164246
96MP0002722_abnormal_immune_system0.61990779
97MP0001958_emphysema0.61223617
98MP0001819_abnormal_immune_cell0.60862993
99MP0004484_altered_response_of0.60302941
100MP0005195_abnormal_posterior_eye0.59411492

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)3.99484169
2Absent/shortened dynein arms (HP:0200106)3.99484169
3Stomatitis (HP:0010280)3.97460015
4Abnormality of the labia minora (HP:0012880)3.94712794
5Nephronophthisis (HP:0000090)3.81005151
6IgG deficiency (HP:0004315)3.26570281
7Acute necrotizing encephalopathy (HP:0006965)3.23026155
8Abnormal hair whorl (HP:0010721)3.17716779
9Abnormality of the renal medulla (HP:0100957)3.03961531
10Increased CSF lactate (HP:0002490)2.98620973
11Tubular atrophy (HP:0000092)2.96423814
12Chronic otitis media (HP:0000389)2.96405523
13Hypoplasia of the uterus (HP:0000013)2.92205482
14T lymphocytopenia (HP:0005403)2.84095016
15Mitochondrial inheritance (HP:0001427)2.84022737
16Acute encephalopathy (HP:0006846)2.83808549
17Molar tooth sign on MRI (HP:0002419)2.83264265
18Abnormality of midbrain morphology (HP:0002418)2.83264265
19Irregular epiphyses (HP:0010582)2.81718237
20Abnormality of the phalanges of the 2nd finger (HP:0009541)2.76949346
21IgA deficiency (HP:0002720)2.73995136
22Carpal bone hypoplasia (HP:0001498)2.71115517
23Muscle fiber splitting (HP:0003555)2.65562892
24Abnormality of the renal cortex (HP:0011035)2.64609885
25Flat capital femoral epiphysis (HP:0003370)2.62271315
26Progressive inability to walk (HP:0002505)2.59856681
27Abnormal mitochondria in muscle tissue (HP:0008316)2.59007218
28Progressive macrocephaly (HP:0004481)2.58946428
29Hepatocellular necrosis (HP:0001404)2.57895676
30Abolished electroretinogram (ERG) (HP:0000550)2.53574088
31Fair hair (HP:0002286)2.53454564
32Congenital stationary night blindness (HP:0007642)2.43393343
33Cerebral edema (HP:0002181)2.42982202
34Respiratory failure (HP:0002878)2.41469154
35Leukodystrophy (HP:0002415)2.39658759
36Abnormal respiratory epithelium morphology (HP:0012253)2.38830143
37Abnormal respiratory motile cilium morphology (HP:0005938)2.38830143
38Inability to walk (HP:0002540)2.36079305
39Abnormality of macular pigmentation (HP:0008002)2.34638284
40Decreased central vision (HP:0007663)2.33576799
41Weak cry (HP:0001612)2.33415087
42Hepatic necrosis (HP:0002605)2.33014237
43Abnormality of T cell number (HP:0011839)2.31650946
44Abnormality of lateral ventricle (HP:0030047)2.29654473
45Chronic sinusitis (HP:0011109)2.27086772
46Optic disc pallor (HP:0000543)2.26960574
47Clitoromegaly (HP:0000057)2.26015620
48Abnormal ciliary motility (HP:0012262)2.25701332
49Abnormal rod and cone electroretinograms (HP:0008323)2.25534394
50Flat face (HP:0012368)2.24711198
51Chronic mucocutaneous candidiasis (HP:0002728)2.22496569
52Recurrent cutaneous fungal infections (HP:0011370)2.22496569
53Abnormality of chromosome stability (HP:0003220)2.19505845
54Attenuation of retinal blood vessels (HP:0007843)2.17475178
55Type 2 muscle fiber atrophy (HP:0003554)2.16004803
56Dyschromatopsia (HP:0007641)2.15595341
57Type I transferrin isoform profile (HP:0003642)2.14203709
58Aplasia/hypoplasia of the uterus (HP:0008684)2.12888833
59Abnormality of homocysteine metabolism (HP:0010919)2.09138338
60Homocystinuria (HP:0002156)2.09138338
61Chronic hepatic failure (HP:0100626)2.09013248
62Increased serum lactate (HP:0002151)2.05364972
63Renal cortical cysts (HP:0000803)2.05326743
64Central scotoma (HP:0000603)2.04473153
65Medial flaring of the eyebrow (HP:0010747)2.04372942
66Polydipsia (HP:0001959)2.04365356
67Abnormal drinking behavior (HP:0030082)2.04365356
683-Methylglutaconic aciduria (HP:0003535)2.02637540
69Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.00657035
70Exertional dyspnea (HP:0002875)2.00007469
71Abnormality of aspartate family amino acid metabolism (HP:0010899)1.99519291
72Abnormality of the clitoris (HP:0000056)1.98067018
73Absent rod-and cone-mediated responses on ERG (HP:0007688)1.94051090
74Tubulointerstitial fibrosis (HP:0005576)1.93369799
75Constricted visual fields (HP:0001133)1.91919188
76Cone-rod dystrophy (HP:0000548)1.88601612
77Methylmalonic acidemia (HP:0002912)1.85334540
78Abnormality of the prostate (HP:0008775)1.84397606
79Generalized hypopigmentation of hair (HP:0011358)1.82747696
80Abnormality of methionine metabolism (HP:0010901)1.81708831
81Intestinal atresia (HP:0011100)1.81534915
82Retinal dysplasia (HP:0007973)1.80878311
83Abnormality of T cells (HP:0002843)1.79513502
84Anteriorly placed anus (HP:0001545)1.79231591
85Pulmonary infiltrates (HP:0002113)1.77638605
86Small hand (HP:0200055)1.77587330
87Small intestinal stenosis (HP:0012848)1.75318162
88Duodenal stenosis (HP:0100867)1.75318162
89Sloping forehead (HP:0000340)1.74770711
90Congenital, generalized hypertrichosis (HP:0004540)1.74252596
91Breast carcinoma (HP:0003002)1.72928631
92Tubulointerstitial abnormality (HP:0001969)1.72180342
93Polyuria (HP:0000103)1.71908384
94Delayed CNS myelination (HP:0002188)1.71328758
95Myelodysplasia (HP:0002863)1.68223005
96Type II lissencephaly (HP:0007260)1.67893312
97Pancreatic fibrosis (HP:0100732)1.67827908
98Hypoplasia of the fovea (HP:0007750)1.67018391
99Aplasia/Hypoplasia of the fovea (HP:0008060)1.67018391
100Cerebellar dysplasia (HP:0007033)1.66443261

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK35.30551330
2EIF2AK13.86931360
3AKT33.83554708
4BUB13.38132329
5BMPR1B3.34634587
6STK38L3.15507595
7ZAK2.57909647
8TXK2.46113723
9NUAK12.36481458
10MAP2K62.06613644
11TSSK62.01902977
12WNK31.93638329
13PKN11.91442453
14EIF2AK21.81433016
15FRK1.72365675
16MKNK11.72113415
17PLK31.66442867
18TYK21.64805822
19TLK11.59273564
20VRK11.44286151
21PNCK1.37213368
22MKNK21.36185166
23MAP3K121.35934138
24NME11.31625790
25MST41.31343661
26MAP3K41.26882904
27BMPR21.24361000
28ADRBK21.21248857
29STK31.17026373
30MET1.15480792
31TAOK31.15440102
32EPHA31.14297253
33EPHA41.11075809
34TRIM281.08500380
35STK241.07462017
36KIT1.03585934
37GRK10.99855554
38MAP2K40.98254984
39STK380.91943190
40DMPK0.86607958
41JAK30.85279235
42RPS6KA40.84062775
43PINK10.81273798
44ACVR1B0.77537334
45DYRK30.75545210
46TGFBR10.75066219
47PLK10.74807372
48FLT30.74550436
49PHKG10.72915751
50PHKG20.72915751
51MAPK150.71878176
52SGK20.70397038
53STK40.70190989
54BRAF0.67264486
55PLK20.67158855
56MINK10.67061869
57TTK0.65846480
58NEK10.62792159
59ERBB30.61323084
60CSNK1A1L0.61273480
61MUSK0.60477709
62PLK40.60234269
63WEE10.58569761
64CSNK1G10.58146299
65CDC70.57973864
66PAK30.54889702
67INSRR0.54212821
68PRKG10.52194300
69ADRBK10.52117771
70IKBKE0.51193823
71EGFR0.50863544
72CAMKK20.48789494
73TEC0.48571420
74OBSCN0.48152225
75CSNK1G30.48011152
76MAP4K20.44582377
77FGFR10.43623559
78ATR0.41449265
79MAPK130.41291229
80PASK0.41101999
81STK160.40315208
82BCR0.38246941
83FGFR20.37669289
84UHMK10.37541421
85MAP3K60.36699988
86MAP2K30.35572061
87ILK0.34447314
88AURKB0.33904614
89RPS6KA50.33421462
90FES0.32943927
91PRKCE0.32447170
92VRK20.32075647
93ATM0.31462840
94CSNK1G20.31460924
95IKBKB0.31414249
96JAK10.31338875
97IGF1R0.30952551
98CDK30.30225293
99CSNK2A10.29172944
100CSF1R0.25982136

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.96990673
2Protein export_Homo sapiens_hsa030603.88889939
3Allograft rejection_Homo sapiens_hsa053303.14947690
4Type I diabetes mellitus_Homo sapiens_hsa049402.63053348
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.50055392
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.40115433
7Graft-versus-host disease_Homo sapiens_hsa053322.34361040
8Homologous recombination_Homo sapiens_hsa034402.23786530
9Asthma_Homo sapiens_hsa053102.23580493
10Fanconi anemia pathway_Homo sapiens_hsa034602.14123290
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.13477248
12Steroid biosynthesis_Homo sapiens_hsa001002.06229515
13Autoimmune thyroid disease_Homo sapiens_hsa053202.02699968
14Basal transcription factors_Homo sapiens_hsa030221.80272619
15RNA degradation_Homo sapiens_hsa030181.76900053
16Fatty acid elongation_Homo sapiens_hsa000621.76780795
17Folate biosynthesis_Homo sapiens_hsa007901.76766958
18Propanoate metabolism_Homo sapiens_hsa006401.75655067
19Rheumatoid arthritis_Homo sapiens_hsa053231.73056213
20Oxidative phosphorylation_Homo sapiens_hsa001901.71383515
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59153269
22Non-homologous end-joining_Homo sapiens_hsa034501.56099950
23Regulation of autophagy_Homo sapiens_hsa041401.51988553
24One carbon pool by folate_Homo sapiens_hsa006701.49542035
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44011662
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41572354
27Parkinsons disease_Homo sapiens_hsa050121.40471019
28Mismatch repair_Homo sapiens_hsa034301.38702711
29Caffeine metabolism_Homo sapiens_hsa002321.35741736
30Linoleic acid metabolism_Homo sapiens_hsa005911.30529118
31RNA transport_Homo sapiens_hsa030131.14200760
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13357263
33beta-Alanine metabolism_Homo sapiens_hsa004101.13312860
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11059716
35Base excision repair_Homo sapiens_hsa034101.10486643
36Primary immunodeficiency_Homo sapiens_hsa053401.07077617
37Antigen processing and presentation_Homo sapiens_hsa046121.05806168
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05727431
39Phototransduction_Homo sapiens_hsa047441.03190015
40Viral myocarditis_Homo sapiens_hsa054161.00614207
41Hematopoietic cell lineage_Homo sapiens_hsa046401.00123251
42Butanoate metabolism_Homo sapiens_hsa006500.99956661
43Huntingtons disease_Homo sapiens_hsa050160.96303724
44Nucleotide excision repair_Homo sapiens_hsa034200.95022443
45Spliceosome_Homo sapiens_hsa030400.94266647
46Vitamin digestion and absorption_Homo sapiens_hsa049770.92437583
47Jak-STAT signaling pathway_Homo sapiens_hsa046300.91972900
48NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90921020
49Ribosome_Homo sapiens_hsa030100.90462714
50Leishmaniasis_Homo sapiens_hsa051400.88535167
51Tryptophan metabolism_Homo sapiens_hsa003800.83533954
52Herpes simplex infection_Homo sapiens_hsa051680.82344510
53Fat digestion and absorption_Homo sapiens_hsa049750.81209617
54RNA polymerase_Homo sapiens_hsa030200.78169627
55Sulfur metabolism_Homo sapiens_hsa009200.77307622
56Purine metabolism_Homo sapiens_hsa002300.76575210
57Arachidonic acid metabolism_Homo sapiens_hsa005900.75619221
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.72946326
59DNA replication_Homo sapiens_hsa030300.72592317
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70647911
61Pyrimidine metabolism_Homo sapiens_hsa002400.69865512
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69746460
63Nicotine addiction_Homo sapiens_hsa050330.69383582
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68524401
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67557397
66Systemic lupus erythematosus_Homo sapiens_hsa053220.65554427
67African trypanosomiasis_Homo sapiens_hsa051430.64493482
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64474460
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.63766595
70Measles_Homo sapiens_hsa051620.63032805
71p53 signaling pathway_Homo sapiens_hsa041150.62190012
72Ether lipid metabolism_Homo sapiens_hsa005650.61711987
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61402130
74T cell receptor signaling pathway_Homo sapiens_hsa046600.60373061
75Alzheimers disease_Homo sapiens_hsa050100.60204104
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57536239
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53428576
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52256431
79TGF-beta signaling pathway_Homo sapiens_hsa043500.50507015
80Legionellosis_Homo sapiens_hsa051340.49260166
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.45776407
82Peroxisome_Homo sapiens_hsa041460.45226911
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44908919
84Salmonella infection_Homo sapiens_hsa051320.44888006
85Cell cycle_Homo sapiens_hsa041100.44450235
86Malaria_Homo sapiens_hsa051440.42981100
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42580757
88Toxoplasmosis_Homo sapiens_hsa051450.41893445
89Circadian rhythm_Homo sapiens_hsa047100.41114211
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40743179
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.38967197
92Pyruvate metabolism_Homo sapiens_hsa006200.38580074
93Oocyte meiosis_Homo sapiens_hsa041140.37186860
94Epstein-Barr virus infection_Homo sapiens_hsa051690.37137105
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35345650
96Fatty acid metabolism_Homo sapiens_hsa012120.34284108
97mRNA surveillance pathway_Homo sapiens_hsa030150.33242784
98Retinol metabolism_Homo sapiens_hsa008300.30533351
99Metabolic pathways_Homo sapiens_hsa011000.30184581
100Cardiac muscle contraction_Homo sapiens_hsa042600.29412959

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