CACYBPP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.89051877
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.52522760
3ATP synthesis coupled proton transport (GO:0015986)5.52522760
4establishment of protein localization to mitochondrial membrane (GO:0090151)5.17313373
5proteasome assembly (GO:0043248)4.82730158
6DNA deamination (GO:0045006)4.64491297
7chaperone-mediated protein transport (GO:0072321)4.48347598
8chromatin remodeling at centromere (GO:0031055)4.46279341
9CENP-A containing nucleosome assembly (GO:0034080)4.42791799
10protein neddylation (GO:0045116)4.42280060
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.34955189
12cullin deneddylation (GO:0010388)4.31788654
13nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.26596871
14protein deneddylation (GO:0000338)4.22320992
15exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.21281389
16ribosomal large subunit biogenesis (GO:0042273)4.15467615
17negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.12551406
18maturation of 5.8S rRNA (GO:0000460)4.06435164
19histone exchange (GO:0043486)4.03061448
20respiratory electron transport chain (GO:0022904)3.93819414
21mitochondrial respiratory chain complex assembly (GO:0033108)3.91392473
22ribosome assembly (GO:0042255)3.91286308
23electron transport chain (GO:0022900)3.89454851
24protein complex biogenesis (GO:0070271)3.86778303
25respiratory chain complex IV assembly (GO:0008535)3.84078314
26DNA double-strand break processing (GO:0000729)3.79583138
27regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.79420984
28positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.75770359
29transcription elongation from RNA polymerase III promoter (GO:0006385)3.70167822
30termination of RNA polymerase III transcription (GO:0006386)3.70167822
31negative regulation of ligase activity (GO:0051352)3.68162221
32negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.68162221
33somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.65734539
34isotype switching (GO:0045190)3.65734539
35somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.65734539
36rRNA modification (GO:0000154)3.64768146
37regulation of cellular amino acid metabolic process (GO:0006521)3.62234727
38DNA damage response, detection of DNA damage (GO:0042769)3.53371737
39cytochrome complex assembly (GO:0017004)3.46342108
40anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.45010832
41DNA replication-dependent nucleosome organization (GO:0034723)3.44895273
42DNA replication-dependent nucleosome assembly (GO:0006335)3.44895273
43organelle disassembly (GO:1903008)3.44091257
44water-soluble vitamin biosynthetic process (GO:0042364)3.41977085
45establishment of integrated proviral latency (GO:0075713)3.41365357
46mitochondrial respiratory chain complex I assembly (GO:0032981)3.40425075
47NADH dehydrogenase complex assembly (GO:0010257)3.40425075
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40425075
49RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.38540955
50DNA replication checkpoint (GO:0000076)3.36994453
51regulation of mitotic spindle checkpoint (GO:1903504)3.36991905
52regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.36991905
53DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.35820433
54DNA ligation (GO:0006266)3.35663203
55signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.35416121
56signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.35416121
57signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.35416121
58negative regulation of DNA-dependent DNA replication (GO:2000104)3.31044202
59intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.28276883
60signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.28276883
61DNA catabolic process, exonucleolytic (GO:0000738)3.27493165
62DNA replication-independent nucleosome assembly (GO:0006336)3.23107186
63DNA replication-independent nucleosome organization (GO:0034724)3.23107186
64RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.22850506
65tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.22850506
66pseudouridine synthesis (GO:0001522)3.21681316
67signal transduction involved in DNA integrity checkpoint (GO:0072401)3.20847368
68signal transduction involved in DNA damage checkpoint (GO:0072422)3.20847368
69spliceosomal snRNP assembly (GO:0000387)3.20663941
70positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.19394866
71signal transduction involved in cell cycle checkpoint (GO:0072395)3.15816676
72non-recombinational repair (GO:0000726)3.13649871
73double-strand break repair via nonhomologous end joining (GO:0006303)3.13649871
74kynurenine metabolic process (GO:0070189)3.13592877
75transcription from mitochondrial promoter (GO:0006390)3.10909933
76histone mRNA metabolic process (GO:0008334)3.08475557
77oxidative phosphorylation (GO:0006119)3.08399480
78positive regulation of ligase activity (GO:0051351)3.06475849
79maturation of SSU-rRNA (GO:0030490)3.06290744
80protein-cofactor linkage (GO:0018065)3.04553571
81regulation of helicase activity (GO:0051095)2.96664925
82synapsis (GO:0007129)2.95616623
83ATP biosynthetic process (GO:0006754)2.91665587
84purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.88144887
85rRNA processing (GO:0006364)2.87953814
86tryptophan catabolic process (GO:0006569)2.87609686
87indole-containing compound catabolic process (GO:0042436)2.87609686
88indolalkylamine catabolic process (GO:0046218)2.87609686
89translation (GO:0006412)2.86127261
90purine nucleoside triphosphate biosynthetic process (GO:0009145)2.84829493
91telomere maintenance via semi-conservative replication (GO:0032201)2.83876783
92inner mitochondrial membrane organization (GO:0007007)2.83345135
93regulation of ubiquitin-protein transferase activity (GO:0051438)2.82998513
94rRNA metabolic process (GO:0016072)2.77558365
95antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.75963386
96tRNA processing (GO:0008033)2.75044740
97somatic hypermutation of immunoglobulin genes (GO:0016446)2.74419854
98somatic diversification of immune receptors via somatic mutation (GO:0002566)2.74419854
99somatic recombination of immunoglobulin gene segments (GO:0016447)2.74170986
100replication fork processing (GO:0031297)2.74154957

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.01941644
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.43418543
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.02882309
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.31613018
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.08780105
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.99620783
7E2F7_22180533_ChIP-Seq_HELA_Human2.94336464
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.86492110
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.86077793
10ELK1_19687146_ChIP-ChIP_HELA_Human2.81784037
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.66516667
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.65139611
13VDR_23849224_ChIP-Seq_CD4+_Human2.62217847
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.58054446
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.53163788
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52214649
17VDR_22108803_ChIP-Seq_LS180_Human2.47004448
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.43386976
19FOXP3_21729870_ChIP-Seq_TREG_Human2.22107706
20EWS_26573619_Chip-Seq_HEK293_Human2.11872128
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08319190
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.03604516
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.00917853
24ZNF274_21170338_ChIP-Seq_K562_Hela1.97227198
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92469681
26MYC_19030024_ChIP-ChIP_MESCs_Mouse1.92143169
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91028526
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.84175551
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.83125393
30MYC_18940864_ChIP-ChIP_HL60_Human1.82268350
31FUS_26573619_Chip-Seq_HEK293_Human1.80868523
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.79851071
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77732268
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.74499411
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.65676913
36TAF15_26573619_Chip-Seq_HEK293_Human1.63657245
37IGF1R_20145208_ChIP-Seq_DFB_Human1.62993075
38TTF2_22483619_ChIP-Seq_HELA_Human1.61259416
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60409858
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59042084
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58129198
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.57915780
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.53771107
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.51613632
45DCP1A_22483619_ChIP-Seq_HELA_Human1.51601115
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49670214
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.49569955
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45194646
49P300_19829295_ChIP-Seq_ESCs_Human1.42287102
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37675945
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.30850101
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30760979
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27283893
54GABP_19822575_ChIP-Seq_HepG2_Human1.25467497
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25401836
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25334870
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22746840
58IRF1_19129219_ChIP-ChIP_H3396_Human1.21259188
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20298232
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19411256
61NANOG_16153702_ChIP-ChIP_HESCs_Human1.18843868
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18071666
63ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17848676
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16246937
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15968246
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15877244
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14946023
68AR_21909140_ChIP-Seq_LNCAP_Human1.14299534
69YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13598571
70GBX2_23144817_ChIP-Seq_PC3_Human1.12935381
71IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12483967
72SOX2_19829295_ChIP-Seq_ESCs_Human1.12450584
73NANOG_19829295_ChIP-Seq_ESCs_Human1.12450584
74KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11773201
75TP53_22573176_ChIP-Seq_HFKS_Human1.11643139
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.03714533
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03008189
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02468498
79FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01732751
80FOXA1_25329375_ChIP-Seq_VCAP_Human1.01732751
81AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01627809
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01079022
83XRN2_22483619_ChIP-Seq_HELA_Human1.00426507
84SOX2_16153702_ChIP-ChIP_HESCs_Human1.00396390
85PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99404258
86ELK1_22589737_ChIP-Seq_MCF10A_Human0.98703350
87CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97415110
88EZH2_27294783_Chip-Seq_NPCs_Mouse0.96585854
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96480941
90NOTCH1_21737748_ChIP-Seq_TLL_Human0.96195922
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95926017
92CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95711196
93MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94913520
94POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92671627
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92450650
96SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92146484
97ER_23166858_ChIP-Seq_MCF-7_Human0.92049583
98CBP_20019798_ChIP-Seq_JUKART_Human0.91789428
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91789428
100GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90559683

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.29092303
2MP0010094_abnormal_chromosome_stability3.63952541
3MP0008058_abnormal_DNA_repair3.55392180
4MP0008877_abnormal_DNA_methylation3.14758882
5MP0004957_abnormal_blastocyst_morpholog2.93127249
6MP0006072_abnormal_retinal_apoptosis2.85728078
7MP0003693_abnormal_embryo_hatching2.61870610
8MP0008875_abnormal_xenobiotic_pharmacok2.38826360
9MP0002102_abnormal_ear_morphology2.31277035
10MP0005084_abnormal_gallbladder_morpholo2.19863503
11MP0001529_abnormal_vocalization2.12050880
12MP0002736_abnormal_nociception_after2.09974835
13MP0006036_abnormal_mitochondrial_physio2.06563557
14MP0008007_abnormal_cellular_replicative2.05061638
15MP0003718_maternal_effect2.04791828
16MP0001293_anophthalmia2.01800129
17MP0003195_calcinosis1.99472607
18MP0003077_abnormal_cell_cycle1.94624849
19MP0003786_premature_aging1.89759101
20MP0008932_abnormal_embryonic_tissue1.84516147
21MP0006292_abnormal_olfactory_placode1.76586891
22MP0003111_abnormal_nucleus_morphology1.71986087
23MP0002938_white_spotting1.70611379
24MP0001968_abnormal_touch/_nociception1.70489489
25MP0009697_abnormal_copulation1.66678152
26MP0008872_abnormal_physiological_respon1.63675282
27MP0006035_abnormal_mitochondrial_morpho1.59424463
28MP0003186_abnormal_redox_activity1.56914301
29MP0002138_abnormal_hepatobiliary_system1.54421848
30MP0002735_abnormal_chemical_nociception1.49772554
31MP0003890_abnormal_embryonic-extraembry1.48575652
32MP0001485_abnormal_pinna_reflex1.46782134
33MP0006054_spinal_hemorrhage1.43242696
34MP0002638_abnormal_pupillary_reflex1.42368576
35MP0000372_irregular_coat_pigmentation1.36651015
36MP0005253_abnormal_eye_physiology1.32762554
37MP0001188_hyperpigmentation1.32358330
38MP0009046_muscle_twitch1.31063645
39MP0003121_genomic_imprinting1.29247143
40MP0004147_increased_porphyrin_level1.28628211
41MP0005671_abnormal_response_to1.27013744
42MP0005075_abnormal_melanosome_morpholog1.23501258
43MP0002272_abnormal_nervous_system1.23122668
44MP0002160_abnormal_reproductive_system1.23027329
45MP0004215_abnormal_myocardial_fiber1.21139844
46MP0001905_abnormal_dopamine_level1.18155513
47MP0005551_abnormal_eye_electrophysiolog1.17462563
48MP0003567_abnormal_fetal_cardiomyocyte1.14487704
49MP0004145_abnormal_muscle_electrophysio1.14140764
50MP0005646_abnormal_pituitary_gland1.11919007
51MP0003787_abnormal_imprinting1.11231827
52MP0003941_abnormal_skin_development1.08637446
53MP0001835_abnormal_antigen_presentation1.08262276
54MP0003937_abnormal_limbs/digits/tail_de1.07848603
55MP0005389_reproductive_system_phenotype1.07424587
56MP0002751_abnormal_autonomic_nervous1.06963832
57MP0003119_abnormal_digestive_system1.06710923
58MP0003011_delayed_dark_adaptation1.04921521
59MP0002837_dystrophic_cardiac_calcinosis1.04717062
60MP0002277_abnormal_respiratory_mucosa1.01486807
61MP0010386_abnormal_urinary_bladder1.01013049
62MP0008995_early_reproductive_senescence0.97513613
63MP0009764_decreased_sensitivity_to0.95370592
64MP0002148_abnormal_hypersensitivity_rea0.95045826
65MP0001984_abnormal_olfaction0.92808703
66MP0009745_abnormal_behavioral_response0.92096119
67MP0001929_abnormal_gametogenesis0.90322655
68MP0001177_atelectasis0.87612008
69MP0004142_abnormal_muscle_tone0.87088592
70MP0001764_abnormal_homeostasis0.86367718
71MP0009379_abnormal_foot_pigmentation0.85977905
72MP0002210_abnormal_sex_determination0.85468044
73MP0002282_abnormal_trachea_morphology0.84687792
74MP0000358_abnormal_cell_content/0.83957452
75MP0003137_abnormal_impulse_conducting0.82053519
76MP0005367_renal/urinary_system_phenotyp0.81772909
77MP0000516_abnormal_urinary_system0.81772909
78MP0008873_increased_physiological_sensi0.81564526
79MP0006276_abnormal_autonomic_nervous0.80323470
80MP0004885_abnormal_endolymph0.78283715
81MP0003136_yellow_coat_color0.78035442
82MP0009785_altered_susceptibility_to0.77946980
83MP0005645_abnormal_hypothalamus_physiol0.77074412
84MP0000631_abnormal_neuroendocrine_gland0.76292735
85MP0000653_abnormal_sex_gland0.76288883
86MP0002006_tumorigenesis0.72988261
87MP0001145_abnormal_male_reproductive0.72109691
88MP0001486_abnormal_startle_reflex0.71058583
89MP0001286_abnormal_eye_development0.68517648
90MP0001970_abnormal_pain_threshold0.68351297
91MP0005391_vision/eye_phenotype0.67643135
92MP0008789_abnormal_olfactory_epithelium0.67445322
93MP0005332_abnormal_amino_acid0.65022142
94MP0003646_muscle_fatigue0.64902649
95MP0005410_abnormal_fertilization0.64557055
96MP0001119_abnormal_female_reproductive0.63719954
97MP0003880_abnormal_central_pattern0.62859229
98MP0002234_abnormal_pharynx_morphology0.62571216
99MP0002572_abnormal_emotion/affect_behav0.61616973
100MP0008775_abnormal_heart_ventricle0.61243237

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.39713876
2Abnormal mitochondria in muscle tissue (HP:0008316)4.96077269
3Acute encephalopathy (HP:0006846)4.73347086
4Progressive macrocephaly (HP:0004481)4.57015959
5Mitochondrial inheritance (HP:0001427)4.52252230
6Increased CSF lactate (HP:0002490)4.26605233
73-Methylglutaconic aciduria (HP:0003535)3.91638190
8Hepatocellular necrosis (HP:0001404)3.89429161
9Increased hepatocellular lipid droplets (HP:0006565)3.87701283
10Cerebral edema (HP:0002181)3.62563844
11Hepatic necrosis (HP:0002605)3.52671884
12Lipid accumulation in hepatocytes (HP:0006561)3.40453932
13Methylmalonic acidemia (HP:0002912)3.38408464
14Congenital, generalized hypertrichosis (HP:0004540)3.31749625
15Increased serum lactate (HP:0002151)3.08396541
16Renal Fanconi syndrome (HP:0001994)3.04385204
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.99480812
18Decreased activity of mitochondrial respiratory chain (HP:0008972)2.99480812
19Exertional dyspnea (HP:0002875)2.94809175
20Abnormality of alanine metabolism (HP:0010916)2.91192030
21Hyperalaninemia (HP:0003348)2.91192030
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.91192030
23Lactic acidosis (HP:0003128)2.88076276
24Leukodystrophy (HP:0002415)2.84861842
25Increased intramyocellular lipid droplets (HP:0012240)2.84860181
26Type I transferrin isoform profile (HP:0003642)2.80703734
27Hyperglycinemia (HP:0002154)2.76042656
28Abnormality of serum amino acid levels (HP:0003112)2.74915855
29Pancreatic cysts (HP:0001737)2.72847326
30Abnormality of aspartate family amino acid metabolism (HP:0010899)2.72674779
31Methylmalonic aciduria (HP:0012120)2.65664482
32Respiratory failure (HP:0002878)2.61613708
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.60479395
34Colon cancer (HP:0003003)2.59287938
35Abnormality of methionine metabolism (HP:0010901)2.57301544
36Optic disc pallor (HP:0000543)2.47137459
37Abnormality of the ileum (HP:0001549)2.43647582
38Abnormality of the labia minora (HP:0012880)2.43082751
39Abolished electroretinogram (ERG) (HP:0000550)2.41498336
40Exercise intolerance (HP:0003546)2.37993407
41Meckel diverticulum (HP:0002245)2.37520855
42Molar tooth sign on MRI (HP:0002419)2.37424318
43Abnormality of midbrain morphology (HP:0002418)2.37424318
44Lethargy (HP:0001254)2.35684682
45Nephronophthisis (HP:0000090)2.30847597
46Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.24980973
47Degeneration of anterior horn cells (HP:0002398)2.22577304
48Abnormality of the anterior horn cell (HP:0006802)2.22577304
49Respiratory difficulties (HP:0002880)2.22550721
50Type 2 muscle fiber atrophy (HP:0003554)2.17913730
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.17774929
52Stenosis of the external auditory canal (HP:0000402)2.16646111
53Increased muscle lipid content (HP:0009058)2.14643093
54Abnormality of renal resorption (HP:0011038)2.14065528
55Pendular nystagmus (HP:0012043)2.11214005
56Macrocytic anemia (HP:0001972)2.11134068
57Abnormality of chromosome stability (HP:0003220)2.11066451
58Pancreatic fibrosis (HP:0100732)2.10408496
59True hermaphroditism (HP:0010459)2.09060610
60Abnormality of the vitamin B12 metabolism (HP:0004341)2.06974230
61Abnormal protein glycosylation (HP:0012346)2.05801493
62Abnormal glycosylation (HP:0012345)2.05801493
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.05801493
64Abnormal protein N-linked glycosylation (HP:0012347)2.05801493
65Volvulus (HP:0002580)2.04101124
66Abnormality of vitamin B metabolism (HP:0004340)2.00148716
67Supernumerary spleens (HP:0009799)1.98954174
68Septo-optic dysplasia (HP:0100842)1.98570631
69Palpitations (HP:0001962)1.95192960
70Abnormality of the pons (HP:0007361)1.89726548
71Abnormality of glycine metabolism (HP:0010895)1.89265767
72Abnormality of serine family amino acid metabolism (HP:0010894)1.89265767
73Small hand (HP:0200055)1.84879504
74Abnormality of the renal medulla (HP:0100957)1.84127850
75Reduced antithrombin III activity (HP:0001976)1.84107962
76Abnormality of the preputium (HP:0100587)1.84066514
77Aplasia/hypoplasia of the uterus (HP:0008684)1.80195836
78Pancytopenia (HP:0001876)1.79940373
79Neoplasm of the adrenal gland (HP:0100631)1.79511575
80Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.79472003
81Testicular atrophy (HP:0000029)1.78774332
82Hypothermia (HP:0002045)1.77509813
83X-linked dominant inheritance (HP:0001423)1.76249066
84Congenital stationary night blindness (HP:0007642)1.74742068
85Delayed CNS myelination (HP:0002188)1.74666576
86Glycosuria (HP:0003076)1.74644512
87Abnormality of urine glucose concentration (HP:0011016)1.74644512
88Cleft eyelid (HP:0000625)1.74230037
89Bile duct proliferation (HP:0001408)1.73302361
90Abnormal biliary tract physiology (HP:0012439)1.73302361
91CNS demyelination (HP:0007305)1.72270153
92Abnormal lung lobation (HP:0002101)1.71854128
93Hypoplasia of the pons (HP:0012110)1.70777464
94Birth length less than 3rd percentile (HP:0003561)1.70344520
95Rectal fistula (HP:0100590)1.69683232
96Rectovaginal fistula (HP:0000143)1.69683232
97Medial flaring of the eyebrow (HP:0010747)1.68156192
98Chromosomal breakage induced by crosslinking agents (HP:0003221)1.67862903
99Sclerocornea (HP:0000647)1.67440458
100Posterior subcapsular cataract (HP:0007787)1.67355882

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.23008992
2TSSK63.20650878
3MKNK23.06906951
4MKNK12.92204482
5MST42.70999232
6SRPK12.67262155
7VRK22.66317879
8BUB12.62934595
9EIF2AK32.57710711
10CDC72.53392349
11MAP4K22.51476302
12NUAK12.48120148
13BMPR1B2.33189840
14VRK12.28705514
15PLK32.22806403
16EIF2AK12.07706002
17TLK12.06776261
18STK161.96113334
19ACVR1B1.86301502
20NEK11.82708552
21TRIM281.73377260
22TNIK1.70210445
23TAF11.65356026
24TAOK31.64561472
25WNK31.62805419
26TIE11.59926252
27PLK41.48300728
28FRK1.34326543
29TTK1.33773753
30MAP3K121.31300288
31GRK11.30209739
32WEE11.28428394
33OXSR11.23251638
34ERBB31.16830599
35EIF2AK21.15418829
36PNCK1.15377253
37CSNK1G31.14219068
38CSNK1G21.12451197
39ADRBK21.11488669
40PASK1.10093191
41CSNK1G11.08064569
42PLK11.03449381
43ALK0.99661310
44BCKDK0.98935445
45INSRR0.98704334
46PBK0.94148704
47CDK190.90988357
48BRSK20.87305949
49BCR0.85296288
50RPS6KA50.85217260
51CSNK1A1L0.83187118
52KIT0.80241944
53PDK20.80200766
54PINK10.79505995
55PLK20.79305966
56DYRK20.77997058
57ATR0.75766826
58TGFBR10.75766525
59MAPKAPK50.72644249
60AURKB0.70943399
61TXK0.65983538
62DAPK10.61485322
63TEC0.60900066
64PHKG10.59488967
65PHKG20.59488967
66RPS6KA40.57934394
67STK38L0.56483692
68KDR0.55329706
69CSNK2A10.54300268
70CSNK2A20.53142576
71NME10.50394917
72STK390.48412666
73ATM0.47820180
74WNK40.47157368
75ARAF0.46657133
76MAP3K40.46625903
77PRKCG0.44786352
78BMPR20.43189654
79CSNK1E0.41114303
80MINK10.40238571
81CSNK1A10.38066272
82MAPK150.35997661
83PRKCE0.33966179
84ADRBK10.33076514
85IGF1R0.32658006
86MYLK0.30571814
87CSNK1D0.30112363
88MAPKAPK30.29837549
89CHEK10.29794888
90ERBB40.29600313
91AURKA0.29163065
92CHEK20.28288878
93STK30.28184410
94MAP2K70.28122569
95CDK30.27970334
96CASK0.27458135
97MAPK130.26301061
98PRKCQ0.26205737
99NME20.25640825
100ILK0.25481566

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.54588815
2Oxidative phosphorylation_Homo sapiens_hsa001903.54173787
3Protein export_Homo sapiens_hsa030603.30683156
4Parkinsons disease_Homo sapiens_hsa050122.97623239
5Ribosome_Homo sapiens_hsa030102.88469783
6Mismatch repair_Homo sapiens_hsa034302.85670912
7RNA polymerase_Homo sapiens_hsa030202.53276898
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.51522702
9Asthma_Homo sapiens_hsa053102.49740679
10DNA replication_Homo sapiens_hsa030302.47898083
11Caffeine metabolism_Homo sapiens_hsa002322.30448430
12Homologous recombination_Homo sapiens_hsa034402.23122045
13Huntingtons disease_Homo sapiens_hsa050161.98998932
14RNA degradation_Homo sapiens_hsa030181.98928062
15Alzheimers disease_Homo sapiens_hsa050101.93608333
16Spliceosome_Homo sapiens_hsa030401.88700683
17Non-homologous end-joining_Homo sapiens_hsa034501.84492635
18Nucleotide excision repair_Homo sapiens_hsa034201.72025940
19One carbon pool by folate_Homo sapiens_hsa006701.70017082
20RNA transport_Homo sapiens_hsa030131.67215178
21Basal transcription factors_Homo sapiens_hsa030221.65047432
22Allograft rejection_Homo sapiens_hsa053301.58334071
23Fanconi anemia pathway_Homo sapiens_hsa034601.56096510
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.55787284
25Base excision repair_Homo sapiens_hsa034101.55482911
26Propanoate metabolism_Homo sapiens_hsa006401.53088418
27Autoimmune thyroid disease_Homo sapiens_hsa053201.51221293
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.49522292
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47725946
30Type I diabetes mellitus_Homo sapiens_hsa049401.43732188
31Graft-versus-host disease_Homo sapiens_hsa053321.38858177
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38250543
33Pyrimidine metabolism_Homo sapiens_hsa002401.35143224
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32282910
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29143378
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18552497
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15895814
38Purine metabolism_Homo sapiens_hsa002301.13663987
39Cardiac muscle contraction_Homo sapiens_hsa042601.12235835
40Systemic lupus erythematosus_Homo sapiens_hsa053221.08658033
41Antigen processing and presentation_Homo sapiens_hsa046121.07125162
42Fatty acid elongation_Homo sapiens_hsa000621.06772520
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06495278
44Pyruvate metabolism_Homo sapiens_hsa006201.02512641
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.00371284
46Rheumatoid arthritis_Homo sapiens_hsa053230.97013556
47Tryptophan metabolism_Homo sapiens_hsa003800.94445679
48Phototransduction_Homo sapiens_hsa047440.93898742
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82957799
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81458025
51Cell cycle_Homo sapiens_hsa041100.79141126
52Selenocompound metabolism_Homo sapiens_hsa004500.76230231
53Nitrogen metabolism_Homo sapiens_hsa009100.75248256
54Steroid biosynthesis_Homo sapiens_hsa001000.72100449
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70076924
56Sulfur metabolism_Homo sapiens_hsa009200.67393625
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64988299
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.64764126
59Linoleic acid metabolism_Homo sapiens_hsa005910.64491200
60Peroxisome_Homo sapiens_hsa041460.62812749
61Metabolic pathways_Homo sapiens_hsa011000.61983422
62Glutathione metabolism_Homo sapiens_hsa004800.58392391
63Regulation of autophagy_Homo sapiens_hsa041400.57773914
64Chemical carcinogenesis_Homo sapiens_hsa052040.56990300
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56950444
66Oocyte meiosis_Homo sapiens_hsa041140.55963547
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55230902
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55017453
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52312435
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52164750
71Butanoate metabolism_Homo sapiens_hsa006500.50020957
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48621051
73Epstein-Barr virus infection_Homo sapiens_hsa051690.47385975
74Viral myocarditis_Homo sapiens_hsa054160.46491088
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46183191
76Arachidonic acid metabolism_Homo sapiens_hsa005900.45873732
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43030144
78Folate biosynthesis_Homo sapiens_hsa007900.42452799
79mRNA surveillance pathway_Homo sapiens_hsa030150.41833442
80Ether lipid metabolism_Homo sapiens_hsa005650.40827938
81Nicotine addiction_Homo sapiens_hsa050330.40781527
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39812232
83Collecting duct acid secretion_Homo sapiens_hsa049660.38067289
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.37598361
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37302968
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33671968
87Staphylococcus aureus infection_Homo sapiens_hsa051500.33240952
88beta-Alanine metabolism_Homo sapiens_hsa004100.32455879
89p53 signaling pathway_Homo sapiens_hsa041150.31115050
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30727059
91Retinol metabolism_Homo sapiens_hsa008300.30578583
92Herpes simplex infection_Homo sapiens_hsa051680.29684935
93Carbon metabolism_Homo sapiens_hsa012000.27504324
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26875556
95Olfactory transduction_Homo sapiens_hsa047400.26124503
96Vitamin B6 metabolism_Homo sapiens_hsa007500.25624512
97Legionellosis_Homo sapiens_hsa051340.24999943
98Fatty acid degradation_Homo sapiens_hsa000710.23880511
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.21206693
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20765562

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