

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.89051877 |
| 2 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.52522760 |
| 3 | ATP synthesis coupled proton transport (GO:0015986) | 5.52522760 |
| 4 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.17313373 |
| 5 | proteasome assembly (GO:0043248) | 4.82730158 |
| 6 | DNA deamination (GO:0045006) | 4.64491297 |
| 7 | chaperone-mediated protein transport (GO:0072321) | 4.48347598 |
| 8 | chromatin remodeling at centromere (GO:0031055) | 4.46279341 |
| 9 | CENP-A containing nucleosome assembly (GO:0034080) | 4.42791799 |
| 10 | protein neddylation (GO:0045116) | 4.42280060 |
| 11 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.34955189 |
| 12 | cullin deneddylation (GO:0010388) | 4.31788654 |
| 13 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 4.26596871 |
| 14 | protein deneddylation (GO:0000338) | 4.22320992 |
| 15 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 4.21281389 |
| 16 | ribosomal large subunit biogenesis (GO:0042273) | 4.15467615 |
| 17 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.12551406 |
| 18 | maturation of 5.8S rRNA (GO:0000460) | 4.06435164 |
| 19 | histone exchange (GO:0043486) | 4.03061448 |
| 20 | respiratory electron transport chain (GO:0022904) | 3.93819414 |
| 21 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.91392473 |
| 22 | ribosome assembly (GO:0042255) | 3.91286308 |
| 23 | electron transport chain (GO:0022900) | 3.89454851 |
| 24 | protein complex biogenesis (GO:0070271) | 3.86778303 |
| 25 | respiratory chain complex IV assembly (GO:0008535) | 3.84078314 |
| 26 | DNA double-strand break processing (GO:0000729) | 3.79583138 |
| 27 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.79420984 |
| 28 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.75770359 |
| 29 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.70167822 |
| 30 | termination of RNA polymerase III transcription (GO:0006386) | 3.70167822 |
| 31 | negative regulation of ligase activity (GO:0051352) | 3.68162221 |
| 32 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.68162221 |
| 33 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.65734539 |
| 34 | isotype switching (GO:0045190) | 3.65734539 |
| 35 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.65734539 |
| 36 | rRNA modification (GO:0000154) | 3.64768146 |
| 37 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.62234727 |
| 38 | DNA damage response, detection of DNA damage (GO:0042769) | 3.53371737 |
| 39 | cytochrome complex assembly (GO:0017004) | 3.46342108 |
| 40 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.45010832 |
| 41 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.44895273 |
| 42 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.44895273 |
| 43 | organelle disassembly (GO:1903008) | 3.44091257 |
| 44 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.41977085 |
| 45 | establishment of integrated proviral latency (GO:0075713) | 3.41365357 |
| 46 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.40425075 |
| 47 | NADH dehydrogenase complex assembly (GO:0010257) | 3.40425075 |
| 48 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.40425075 |
| 49 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.38540955 |
| 50 | DNA replication checkpoint (GO:0000076) | 3.36994453 |
| 51 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.36991905 |
| 52 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.36991905 |
| 53 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.35820433 |
| 54 | DNA ligation (GO:0006266) | 3.35663203 |
| 55 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.35416121 |
| 56 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.35416121 |
| 57 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.35416121 |
| 58 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.31044202 |
| 59 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.28276883 |
| 60 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.28276883 |
| 61 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.27493165 |
| 62 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.23107186 |
| 63 | DNA replication-independent nucleosome organization (GO:0034724) | 3.23107186 |
| 64 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.22850506 |
| 65 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.22850506 |
| 66 | pseudouridine synthesis (GO:0001522) | 3.21681316 |
| 67 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.20847368 |
| 68 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.20847368 |
| 69 | spliceosomal snRNP assembly (GO:0000387) | 3.20663941 |
| 70 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.19394866 |
| 71 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.15816676 |
| 72 | non-recombinational repair (GO:0000726) | 3.13649871 |
| 73 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.13649871 |
| 74 | kynurenine metabolic process (GO:0070189) | 3.13592877 |
| 75 | transcription from mitochondrial promoter (GO:0006390) | 3.10909933 |
| 76 | histone mRNA metabolic process (GO:0008334) | 3.08475557 |
| 77 | oxidative phosphorylation (GO:0006119) | 3.08399480 |
| 78 | positive regulation of ligase activity (GO:0051351) | 3.06475849 |
| 79 | maturation of SSU-rRNA (GO:0030490) | 3.06290744 |
| 80 | protein-cofactor linkage (GO:0018065) | 3.04553571 |
| 81 | regulation of helicase activity (GO:0051095) | 2.96664925 |
| 82 | synapsis (GO:0007129) | 2.95616623 |
| 83 | ATP biosynthetic process (GO:0006754) | 2.91665587 |
| 84 | purine deoxyribonucleoside triphosphate metabolic process (GO:0009215) | 2.88144887 |
| 85 | rRNA processing (GO:0006364) | 2.87953814 |
| 86 | tryptophan catabolic process (GO:0006569) | 2.87609686 |
| 87 | indole-containing compound catabolic process (GO:0042436) | 2.87609686 |
| 88 | indolalkylamine catabolic process (GO:0046218) | 2.87609686 |
| 89 | translation (GO:0006412) | 2.86127261 |
| 90 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.84829493 |
| 91 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.83876783 |
| 92 | inner mitochondrial membrane organization (GO:0007007) | 2.83345135 |
| 93 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.82998513 |
| 94 | rRNA metabolic process (GO:0016072) | 2.77558365 |
| 95 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.75963386 |
| 96 | tRNA processing (GO:0008033) | 2.75044740 |
| 97 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.74419854 |
| 98 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 2.74419854 |
| 99 | somatic recombination of immunoglobulin gene segments (GO:0016447) | 2.74170986 |
| 100 | replication fork processing (GO:0031297) | 2.74154957 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.01941644 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.43418543 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.02882309 |
| 4 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.31613018 |
| 5 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 3.08780105 |
| 6 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.99620783 |
| 7 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.94336464 |
| 8 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.86492110 |
| 9 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.86077793 |
| 10 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.81784037 |
| 11 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.66516667 |
| 12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.65139611 |
| 13 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.62217847 |
| 14 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.58054446 |
| 15 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.53163788 |
| 16 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.52214649 |
| 17 | VDR_22108803_ChIP-Seq_LS180_Human | 2.47004448 |
| 18 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.43386976 |
| 19 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.22107706 |
| 20 | EWS_26573619_Chip-Seq_HEK293_Human | 2.11872128 |
| 21 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.08319190 |
| 22 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.03604516 |
| 23 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.00917853 |
| 24 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.97227198 |
| 25 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.92469681 |
| 26 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.92143169 |
| 27 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.91028526 |
| 28 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.84175551 |
| 29 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.83125393 |
| 30 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.82268350 |
| 31 | FUS_26573619_Chip-Seq_HEK293_Human | 1.80868523 |
| 32 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.79851071 |
| 33 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.77732268 |
| 34 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.74499411 |
| 35 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.65676913 |
| 36 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.63657245 |
| 37 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.62993075 |
| 38 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.61259416 |
| 39 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.60409858 |
| 40 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.59042084 |
| 41 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.58129198 |
| 42 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.57915780 |
| 43 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.53771107 |
| 44 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.51613632 |
| 45 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.51601115 |
| 46 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.49670214 |
| 47 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.49569955 |
| 48 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.45194646 |
| 49 | P300_19829295_ChIP-Seq_ESCs_Human | 1.42287102 |
| 50 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.37675945 |
| 51 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.30850101 |
| 52 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.30760979 |
| 53 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.27283893 |
| 54 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.25467497 |
| 55 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.25401836 |
| 56 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.25334870 |
| 57 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.22746840 |
| 58 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.21259188 |
| 59 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.20298232 |
| 60 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.19411256 |
| 61 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.18843868 |
| 62 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.18071666 |
| 63 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.17848676 |
| 64 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.16246937 |
| 65 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.15968246 |
| 66 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.15877244 |
| 67 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.14946023 |
| 68 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.14299534 |
| 69 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.13598571 |
| 70 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.12935381 |
| 71 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.12483967 |
| 72 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.12450584 |
| 73 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.12450584 |
| 74 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.11773201 |
| 75 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.11643139 |
| 76 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.03714533 |
| 77 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.03008189 |
| 78 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.02468498 |
| 79 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.01732751 |
| 80 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.01732751 |
| 81 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.01627809 |
| 82 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.01079022 |
| 83 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.00426507 |
| 84 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.00396390 |
| 85 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.99404258 |
| 86 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.98703350 |
| 87 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.97415110 |
| 88 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.96585854 |
| 89 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.96480941 |
| 90 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.96195922 |
| 91 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.95926017 |
| 92 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.95711196 |
| 93 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.94913520 |
| 94 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.92671627 |
| 95 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.92450650 |
| 96 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.92146484 |
| 97 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.92049583 |
| 98 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.91789428 |
| 99 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.91789428 |
| 100 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.90559683 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003806_abnormal_nucleotide_metabolis | 4.29092303 |
| 2 | MP0010094_abnormal_chromosome_stability | 3.63952541 |
| 3 | MP0008058_abnormal_DNA_repair | 3.55392180 |
| 4 | MP0008877_abnormal_DNA_methylation | 3.14758882 |
| 5 | MP0004957_abnormal_blastocyst_morpholog | 2.93127249 |
| 6 | MP0006072_abnormal_retinal_apoptosis | 2.85728078 |
| 7 | MP0003693_abnormal_embryo_hatching | 2.61870610 |
| 8 | MP0008875_abnormal_xenobiotic_pharmacok | 2.38826360 |
| 9 | MP0002102_abnormal_ear_morphology | 2.31277035 |
| 10 | MP0005084_abnormal_gallbladder_morpholo | 2.19863503 |
| 11 | MP0001529_abnormal_vocalization | 2.12050880 |
| 12 | MP0002736_abnormal_nociception_after | 2.09974835 |
| 13 | MP0006036_abnormal_mitochondrial_physio | 2.06563557 |
| 14 | MP0008007_abnormal_cellular_replicative | 2.05061638 |
| 15 | MP0003718_maternal_effect | 2.04791828 |
| 16 | MP0001293_anophthalmia | 2.01800129 |
| 17 | MP0003195_calcinosis | 1.99472607 |
| 18 | MP0003077_abnormal_cell_cycle | 1.94624849 |
| 19 | MP0003786_premature_aging | 1.89759101 |
| 20 | MP0008932_abnormal_embryonic_tissue | 1.84516147 |
| 21 | MP0006292_abnormal_olfactory_placode | 1.76586891 |
| 22 | MP0003111_abnormal_nucleus_morphology | 1.71986087 |
| 23 | MP0002938_white_spotting | 1.70611379 |
| 24 | MP0001968_abnormal_touch/_nociception | 1.70489489 |
| 25 | MP0009697_abnormal_copulation | 1.66678152 |
| 26 | MP0008872_abnormal_physiological_respon | 1.63675282 |
| 27 | MP0006035_abnormal_mitochondrial_morpho | 1.59424463 |
| 28 | MP0003186_abnormal_redox_activity | 1.56914301 |
| 29 | MP0002138_abnormal_hepatobiliary_system | 1.54421848 |
| 30 | MP0002735_abnormal_chemical_nociception | 1.49772554 |
| 31 | MP0003890_abnormal_embryonic-extraembry | 1.48575652 |
| 32 | MP0001485_abnormal_pinna_reflex | 1.46782134 |
| 33 | MP0006054_spinal_hemorrhage | 1.43242696 |
| 34 | MP0002638_abnormal_pupillary_reflex | 1.42368576 |
| 35 | MP0000372_irregular_coat_pigmentation | 1.36651015 |
| 36 | MP0005253_abnormal_eye_physiology | 1.32762554 |
| 37 | MP0001188_hyperpigmentation | 1.32358330 |
| 38 | MP0009046_muscle_twitch | 1.31063645 |
| 39 | MP0003121_genomic_imprinting | 1.29247143 |
| 40 | MP0004147_increased_porphyrin_level | 1.28628211 |
| 41 | MP0005671_abnormal_response_to | 1.27013744 |
| 42 | MP0005075_abnormal_melanosome_morpholog | 1.23501258 |
| 43 | MP0002272_abnormal_nervous_system | 1.23122668 |
| 44 | MP0002160_abnormal_reproductive_system | 1.23027329 |
| 45 | MP0004215_abnormal_myocardial_fiber | 1.21139844 |
| 46 | MP0001905_abnormal_dopamine_level | 1.18155513 |
| 47 | MP0005551_abnormal_eye_electrophysiolog | 1.17462563 |
| 48 | MP0003567_abnormal_fetal_cardiomyocyte | 1.14487704 |
| 49 | MP0004145_abnormal_muscle_electrophysio | 1.14140764 |
| 50 | MP0005646_abnormal_pituitary_gland | 1.11919007 |
| 51 | MP0003787_abnormal_imprinting | 1.11231827 |
| 52 | MP0003941_abnormal_skin_development | 1.08637446 |
| 53 | MP0001835_abnormal_antigen_presentation | 1.08262276 |
| 54 | MP0003937_abnormal_limbs/digits/tail_de | 1.07848603 |
| 55 | MP0005389_reproductive_system_phenotype | 1.07424587 |
| 56 | MP0002751_abnormal_autonomic_nervous | 1.06963832 |
| 57 | MP0003119_abnormal_digestive_system | 1.06710923 |
| 58 | MP0003011_delayed_dark_adaptation | 1.04921521 |
| 59 | MP0002837_dystrophic_cardiac_calcinosis | 1.04717062 |
| 60 | MP0002277_abnormal_respiratory_mucosa | 1.01486807 |
| 61 | MP0010386_abnormal_urinary_bladder | 1.01013049 |
| 62 | MP0008995_early_reproductive_senescence | 0.97513613 |
| 63 | MP0009764_decreased_sensitivity_to | 0.95370592 |
| 64 | MP0002148_abnormal_hypersensitivity_rea | 0.95045826 |
| 65 | MP0001984_abnormal_olfaction | 0.92808703 |
| 66 | MP0009745_abnormal_behavioral_response | 0.92096119 |
| 67 | MP0001929_abnormal_gametogenesis | 0.90322655 |
| 68 | MP0001177_atelectasis | 0.87612008 |
| 69 | MP0004142_abnormal_muscle_tone | 0.87088592 |
| 70 | MP0001764_abnormal_homeostasis | 0.86367718 |
| 71 | MP0009379_abnormal_foot_pigmentation | 0.85977905 |
| 72 | MP0002210_abnormal_sex_determination | 0.85468044 |
| 73 | MP0002282_abnormal_trachea_morphology | 0.84687792 |
| 74 | MP0000358_abnormal_cell_content/ | 0.83957452 |
| 75 | MP0003137_abnormal_impulse_conducting | 0.82053519 |
| 76 | MP0005367_renal/urinary_system_phenotyp | 0.81772909 |
| 77 | MP0000516_abnormal_urinary_system | 0.81772909 |
| 78 | MP0008873_increased_physiological_sensi | 0.81564526 |
| 79 | MP0006276_abnormal_autonomic_nervous | 0.80323470 |
| 80 | MP0004885_abnormal_endolymph | 0.78283715 |
| 81 | MP0003136_yellow_coat_color | 0.78035442 |
| 82 | MP0009785_altered_susceptibility_to | 0.77946980 |
| 83 | MP0005645_abnormal_hypothalamus_physiol | 0.77074412 |
| 84 | MP0000631_abnormal_neuroendocrine_gland | 0.76292735 |
| 85 | MP0000653_abnormal_sex_gland | 0.76288883 |
| 86 | MP0002006_tumorigenesis | 0.72988261 |
| 87 | MP0001145_abnormal_male_reproductive | 0.72109691 |
| 88 | MP0001486_abnormal_startle_reflex | 0.71058583 |
| 89 | MP0001286_abnormal_eye_development | 0.68517648 |
| 90 | MP0001970_abnormal_pain_threshold | 0.68351297 |
| 91 | MP0005391_vision/eye_phenotype | 0.67643135 |
| 92 | MP0008789_abnormal_olfactory_epithelium | 0.67445322 |
| 93 | MP0005332_abnormal_amino_acid | 0.65022142 |
| 94 | MP0003646_muscle_fatigue | 0.64902649 |
| 95 | MP0005410_abnormal_fertilization | 0.64557055 |
| 96 | MP0001119_abnormal_female_reproductive | 0.63719954 |
| 97 | MP0003880_abnormal_central_pattern | 0.62859229 |
| 98 | MP0002234_abnormal_pharynx_morphology | 0.62571216 |
| 99 | MP0002572_abnormal_emotion/affect_behav | 0.61616973 |
| 100 | MP0008775_abnormal_heart_ventricle | 0.61243237 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.39713876 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.96077269 |
| 3 | Acute encephalopathy (HP:0006846) | 4.73347086 |
| 4 | Progressive macrocephaly (HP:0004481) | 4.57015959 |
| 5 | Mitochondrial inheritance (HP:0001427) | 4.52252230 |
| 6 | Increased CSF lactate (HP:0002490) | 4.26605233 |
| 7 | 3-Methylglutaconic aciduria (HP:0003535) | 3.91638190 |
| 8 | Hepatocellular necrosis (HP:0001404) | 3.89429161 |
| 9 | Increased hepatocellular lipid droplets (HP:0006565) | 3.87701283 |
| 10 | Cerebral edema (HP:0002181) | 3.62563844 |
| 11 | Hepatic necrosis (HP:0002605) | 3.52671884 |
| 12 | Lipid accumulation in hepatocytes (HP:0006561) | 3.40453932 |
| 13 | Methylmalonic acidemia (HP:0002912) | 3.38408464 |
| 14 | Congenital, generalized hypertrichosis (HP:0004540) | 3.31749625 |
| 15 | Increased serum lactate (HP:0002151) | 3.08396541 |
| 16 | Renal Fanconi syndrome (HP:0001994) | 3.04385204 |
| 17 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.99480812 |
| 18 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.99480812 |
| 19 | Exertional dyspnea (HP:0002875) | 2.94809175 |
| 20 | Abnormality of alanine metabolism (HP:0010916) | 2.91192030 |
| 21 | Hyperalaninemia (HP:0003348) | 2.91192030 |
| 22 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.91192030 |
| 23 | Lactic acidosis (HP:0003128) | 2.88076276 |
| 24 | Leukodystrophy (HP:0002415) | 2.84861842 |
| 25 | Increased intramyocellular lipid droplets (HP:0012240) | 2.84860181 |
| 26 | Type I transferrin isoform profile (HP:0003642) | 2.80703734 |
| 27 | Hyperglycinemia (HP:0002154) | 2.76042656 |
| 28 | Abnormality of serum amino acid levels (HP:0003112) | 2.74915855 |
| 29 | Pancreatic cysts (HP:0001737) | 2.72847326 |
| 30 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.72674779 |
| 31 | Methylmalonic aciduria (HP:0012120) | 2.65664482 |
| 32 | Respiratory failure (HP:0002878) | 2.61613708 |
| 33 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.60479395 |
| 34 | Colon cancer (HP:0003003) | 2.59287938 |
| 35 | Abnormality of methionine metabolism (HP:0010901) | 2.57301544 |
| 36 | Optic disc pallor (HP:0000543) | 2.47137459 |
| 37 | Abnormality of the ileum (HP:0001549) | 2.43647582 |
| 38 | Abnormality of the labia minora (HP:0012880) | 2.43082751 |
| 39 | Abolished electroretinogram (ERG) (HP:0000550) | 2.41498336 |
| 40 | Exercise intolerance (HP:0003546) | 2.37993407 |
| 41 | Meckel diverticulum (HP:0002245) | 2.37520855 |
| 42 | Molar tooth sign on MRI (HP:0002419) | 2.37424318 |
| 43 | Abnormality of midbrain morphology (HP:0002418) | 2.37424318 |
| 44 | Lethargy (HP:0001254) | 2.35684682 |
| 45 | Nephronophthisis (HP:0000090) | 2.30847597 |
| 46 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.24980973 |
| 47 | Degeneration of anterior horn cells (HP:0002398) | 2.22577304 |
| 48 | Abnormality of the anterior horn cell (HP:0006802) | 2.22577304 |
| 49 | Respiratory difficulties (HP:0002880) | 2.22550721 |
| 50 | Type 2 muscle fiber atrophy (HP:0003554) | 2.17913730 |
| 51 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.17774929 |
| 52 | Stenosis of the external auditory canal (HP:0000402) | 2.16646111 |
| 53 | Increased muscle lipid content (HP:0009058) | 2.14643093 |
| 54 | Abnormality of renal resorption (HP:0011038) | 2.14065528 |
| 55 | Pendular nystagmus (HP:0012043) | 2.11214005 |
| 56 | Macrocytic anemia (HP:0001972) | 2.11134068 |
| 57 | Abnormality of chromosome stability (HP:0003220) | 2.11066451 |
| 58 | Pancreatic fibrosis (HP:0100732) | 2.10408496 |
| 59 | True hermaphroditism (HP:0010459) | 2.09060610 |
| 60 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.06974230 |
| 61 | Abnormal protein glycosylation (HP:0012346) | 2.05801493 |
| 62 | Abnormal glycosylation (HP:0012345) | 2.05801493 |
| 63 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.05801493 |
| 64 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.05801493 |
| 65 | Volvulus (HP:0002580) | 2.04101124 |
| 66 | Abnormality of vitamin B metabolism (HP:0004340) | 2.00148716 |
| 67 | Supernumerary spleens (HP:0009799) | 1.98954174 |
| 68 | Septo-optic dysplasia (HP:0100842) | 1.98570631 |
| 69 | Palpitations (HP:0001962) | 1.95192960 |
| 70 | Abnormality of the pons (HP:0007361) | 1.89726548 |
| 71 | Abnormality of glycine metabolism (HP:0010895) | 1.89265767 |
| 72 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.89265767 |
| 73 | Small hand (HP:0200055) | 1.84879504 |
| 74 | Abnormality of the renal medulla (HP:0100957) | 1.84127850 |
| 75 | Reduced antithrombin III activity (HP:0001976) | 1.84107962 |
| 76 | Abnormality of the preputium (HP:0100587) | 1.84066514 |
| 77 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.80195836 |
| 78 | Pancytopenia (HP:0001876) | 1.79940373 |
| 79 | Neoplasm of the adrenal gland (HP:0100631) | 1.79511575 |
| 80 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 1.79472003 |
| 81 | Testicular atrophy (HP:0000029) | 1.78774332 |
| 82 | Hypothermia (HP:0002045) | 1.77509813 |
| 83 | X-linked dominant inheritance (HP:0001423) | 1.76249066 |
| 84 | Congenital stationary night blindness (HP:0007642) | 1.74742068 |
| 85 | Delayed CNS myelination (HP:0002188) | 1.74666576 |
| 86 | Glycosuria (HP:0003076) | 1.74644512 |
| 87 | Abnormality of urine glucose concentration (HP:0011016) | 1.74644512 |
| 88 | Cleft eyelid (HP:0000625) | 1.74230037 |
| 89 | Bile duct proliferation (HP:0001408) | 1.73302361 |
| 90 | Abnormal biliary tract physiology (HP:0012439) | 1.73302361 |
| 91 | CNS demyelination (HP:0007305) | 1.72270153 |
| 92 | Abnormal lung lobation (HP:0002101) | 1.71854128 |
| 93 | Hypoplasia of the pons (HP:0012110) | 1.70777464 |
| 94 | Birth length less than 3rd percentile (HP:0003561) | 1.70344520 |
| 95 | Rectal fistula (HP:0100590) | 1.69683232 |
| 96 | Rectovaginal fistula (HP:0000143) | 1.69683232 |
| 97 | Medial flaring of the eyebrow (HP:0010747) | 1.68156192 |
| 98 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.67862903 |
| 99 | Sclerocornea (HP:0000647) | 1.67440458 |
| 100 | Posterior subcapsular cataract (HP:0007787) | 1.67355882 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ZAK | 3.23008992 |
| 2 | TSSK6 | 3.20650878 |
| 3 | MKNK2 | 3.06906951 |
| 4 | MKNK1 | 2.92204482 |
| 5 | MST4 | 2.70999232 |
| 6 | SRPK1 | 2.67262155 |
| 7 | VRK2 | 2.66317879 |
| 8 | BUB1 | 2.62934595 |
| 9 | EIF2AK3 | 2.57710711 |
| 10 | CDC7 | 2.53392349 |
| 11 | MAP4K2 | 2.51476302 |
| 12 | NUAK1 | 2.48120148 |
| 13 | BMPR1B | 2.33189840 |
| 14 | VRK1 | 2.28705514 |
| 15 | PLK3 | 2.22806403 |
| 16 | EIF2AK1 | 2.07706002 |
| 17 | TLK1 | 2.06776261 |
| 18 | STK16 | 1.96113334 |
| 19 | ACVR1B | 1.86301502 |
| 20 | NEK1 | 1.82708552 |
| 21 | TRIM28 | 1.73377260 |
| 22 | TNIK | 1.70210445 |
| 23 | TAF1 | 1.65356026 |
| 24 | TAOK3 | 1.64561472 |
| 25 | WNK3 | 1.62805419 |
| 26 | TIE1 | 1.59926252 |
| 27 | PLK4 | 1.48300728 |
| 28 | FRK | 1.34326543 |
| 29 | TTK | 1.33773753 |
| 30 | MAP3K12 | 1.31300288 |
| 31 | GRK1 | 1.30209739 |
| 32 | WEE1 | 1.28428394 |
| 33 | OXSR1 | 1.23251638 |
| 34 | ERBB3 | 1.16830599 |
| 35 | EIF2AK2 | 1.15418829 |
| 36 | PNCK | 1.15377253 |
| 37 | CSNK1G3 | 1.14219068 |
| 38 | CSNK1G2 | 1.12451197 |
| 39 | ADRBK2 | 1.11488669 |
| 40 | PASK | 1.10093191 |
| 41 | CSNK1G1 | 1.08064569 |
| 42 | PLK1 | 1.03449381 |
| 43 | ALK | 0.99661310 |
| 44 | BCKDK | 0.98935445 |
| 45 | INSRR | 0.98704334 |
| 46 | PBK | 0.94148704 |
| 47 | CDK19 | 0.90988357 |
| 48 | BRSK2 | 0.87305949 |
| 49 | BCR | 0.85296288 |
| 50 | RPS6KA5 | 0.85217260 |
| 51 | CSNK1A1L | 0.83187118 |
| 52 | KIT | 0.80241944 |
| 53 | PDK2 | 0.80200766 |
| 54 | PINK1 | 0.79505995 |
| 55 | PLK2 | 0.79305966 |
| 56 | DYRK2 | 0.77997058 |
| 57 | ATR | 0.75766826 |
| 58 | TGFBR1 | 0.75766525 |
| 59 | MAPKAPK5 | 0.72644249 |
| 60 | AURKB | 0.70943399 |
| 61 | TXK | 0.65983538 |
| 62 | DAPK1 | 0.61485322 |
| 63 | TEC | 0.60900066 |
| 64 | PHKG1 | 0.59488967 |
| 65 | PHKG2 | 0.59488967 |
| 66 | RPS6KA4 | 0.57934394 |
| 67 | STK38L | 0.56483692 |
| 68 | KDR | 0.55329706 |
| 69 | CSNK2A1 | 0.54300268 |
| 70 | CSNK2A2 | 0.53142576 |
| 71 | NME1 | 0.50394917 |
| 72 | STK39 | 0.48412666 |
| 73 | ATM | 0.47820180 |
| 74 | WNK4 | 0.47157368 |
| 75 | ARAF | 0.46657133 |
| 76 | MAP3K4 | 0.46625903 |
| 77 | PRKCG | 0.44786352 |
| 78 | BMPR2 | 0.43189654 |
| 79 | CSNK1E | 0.41114303 |
| 80 | MINK1 | 0.40238571 |
| 81 | CSNK1A1 | 0.38066272 |
| 82 | MAPK15 | 0.35997661 |
| 83 | PRKCE | 0.33966179 |
| 84 | ADRBK1 | 0.33076514 |
| 85 | IGF1R | 0.32658006 |
| 86 | MYLK | 0.30571814 |
| 87 | CSNK1D | 0.30112363 |
| 88 | MAPKAPK3 | 0.29837549 |
| 89 | CHEK1 | 0.29794888 |
| 90 | ERBB4 | 0.29600313 |
| 91 | AURKA | 0.29163065 |
| 92 | CHEK2 | 0.28288878 |
| 93 | STK3 | 0.28184410 |
| 94 | MAP2K7 | 0.28122569 |
| 95 | CDK3 | 0.27970334 |
| 96 | CASK | 0.27458135 |
| 97 | MAPK13 | 0.26301061 |
| 98 | PRKCQ | 0.26205737 |
| 99 | NME2 | 0.25640825 |
| 100 | ILK | 0.25481566 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.54588815 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.54173787 |
| 3 | Protein export_Homo sapiens_hsa03060 | 3.30683156 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 2.97623239 |
| 5 | Ribosome_Homo sapiens_hsa03010 | 2.88469783 |
| 6 | Mismatch repair_Homo sapiens_hsa03430 | 2.85670912 |
| 7 | RNA polymerase_Homo sapiens_hsa03020 | 2.53276898 |
| 8 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.51522702 |
| 9 | Asthma_Homo sapiens_hsa05310 | 2.49740679 |
| 10 | DNA replication_Homo sapiens_hsa03030 | 2.47898083 |
| 11 | Caffeine metabolism_Homo sapiens_hsa00232 | 2.30448430 |
| 12 | Homologous recombination_Homo sapiens_hsa03440 | 2.23122045 |
| 13 | Huntingtons disease_Homo sapiens_hsa05016 | 1.98998932 |
| 14 | RNA degradation_Homo sapiens_hsa03018 | 1.98928062 |
| 15 | Alzheimers disease_Homo sapiens_hsa05010 | 1.93608333 |
| 16 | Spliceosome_Homo sapiens_hsa03040 | 1.88700683 |
| 17 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.84492635 |
| 18 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.72025940 |
| 19 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.70017082 |
| 20 | RNA transport_Homo sapiens_hsa03013 | 1.67215178 |
| 21 | Basal transcription factors_Homo sapiens_hsa03022 | 1.65047432 |
| 22 | Allograft rejection_Homo sapiens_hsa05330 | 1.58334071 |
| 23 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.56096510 |
| 24 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.55787284 |
| 25 | Base excision repair_Homo sapiens_hsa03410 | 1.55482911 |
| 26 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.53088418 |
| 27 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.51221293 |
| 28 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.49522292 |
| 29 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.47725946 |
| 30 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.43732188 |
| 31 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.38858177 |
| 32 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.38250543 |
| 33 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.35143224 |
| 34 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.32282910 |
| 35 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.29143378 |
| 36 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.18552497 |
| 37 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.15895814 |
| 38 | Purine metabolism_Homo sapiens_hsa00230 | 1.13663987 |
| 39 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.12235835 |
| 40 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.08658033 |
| 41 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.07125162 |
| 42 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.06772520 |
| 43 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.06495278 |
| 44 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.02512641 |
| 45 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.00371284 |
| 46 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.97013556 |
| 47 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.94445679 |
| 48 | Phototransduction_Homo sapiens_hsa04744 | 0.93898742 |
| 49 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.82957799 |
| 50 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.81458025 |
| 51 | Cell cycle_Homo sapiens_hsa04110 | 0.79141126 |
| 52 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.76230231 |
| 53 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.75248256 |
| 54 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.72100449 |
| 55 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.70076924 |
| 56 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.67393625 |
| 57 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.64988299 |
| 58 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.64764126 |
| 59 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.64491200 |
| 60 | Peroxisome_Homo sapiens_hsa04146 | 0.62812749 |
| 61 | Metabolic pathways_Homo sapiens_hsa01100 | 0.61983422 |
| 62 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.58392391 |
| 63 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.57773914 |
| 64 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.56990300 |
| 65 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.56950444 |
| 66 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.55963547 |
| 67 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.55230902 |
| 68 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.55017453 |
| 69 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.52312435 |
| 70 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.52164750 |
| 71 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.50020957 |
| 72 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.48621051 |
| 73 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.47385975 |
| 74 | Viral myocarditis_Homo sapiens_hsa05416 | 0.46491088 |
| 75 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.46183191 |
| 76 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.45873732 |
| 77 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.43030144 |
| 78 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.42452799 |
| 79 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.41833442 |
| 80 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.40827938 |
| 81 | Nicotine addiction_Homo sapiens_hsa05033 | 0.40781527 |
| 82 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.39812232 |
| 83 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.38067289 |
| 84 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.37598361 |
| 85 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.37302968 |
| 86 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.33671968 |
| 87 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.33240952 |
| 88 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.32455879 |
| 89 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.31115050 |
| 90 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.30727059 |
| 91 | Retinol metabolism_Homo sapiens_hsa00830 | 0.30578583 |
| 92 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.29684935 |
| 93 | Carbon metabolism_Homo sapiens_hsa01200 | 0.27504324 |
| 94 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.26875556 |
| 95 | Olfactory transduction_Homo sapiens_hsa04740 | 0.26124503 |
| 96 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.25624512 |
| 97 | Legionellosis_Homo sapiens_hsa05134 | 0.24999943 |
| 98 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.23880511 |
| 99 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.21206693 |
| 100 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.20765562 |

