CAD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.55591557
2nuclear pore organization (GO:0006999)5.28745096
3nuclear pore complex assembly (GO:0051292)5.25761274
4folic acid-containing compound biosynthetic process (GO:0009396)5.05010239
5protein localization to kinetochore (GO:0034501)4.83993111
6mitotic nuclear envelope disassembly (GO:0007077)4.53049566
7IMP biosynthetic process (GO:0006188)4.52083072
8regulation of translational fidelity (GO:0006450)4.39510877
9DNA replication initiation (GO:0006270)4.30452034
10membrane disassembly (GO:0030397)4.23009430
11nuclear envelope disassembly (GO:0051081)4.23009430
12pre-miRNA processing (GO:0031054)4.20111138
13formation of translation preinitiation complex (GO:0001731)4.14005063
14DNA replication-dependent nucleosome organization (GO:0034723)4.13742632
15DNA replication-dependent nucleosome assembly (GO:0006335)4.13742632
16DNA strand elongation involved in DNA replication (GO:0006271)4.12629281
17heterochromatin organization (GO:0070828)4.10393529
18regulation of gene silencing by RNA (GO:0060966)4.05810968
19regulation of posttranscriptional gene silencing (GO:0060147)4.05810968
20regulation of gene silencing by miRNA (GO:0060964)4.05810968
21DNA duplex unwinding (GO:0032508)3.97380160
22pore complex assembly (GO:0046931)3.96169967
23DNA geometric change (GO:0032392)3.94782431
24protein localization to chromosome, centromeric region (GO:0071459)3.93186091
25DNA strand elongation (GO:0022616)3.92069948
26IMP metabolic process (GO:0046040)3.84239777
27DNA topological change (GO:0006265)3.83818988
28regulation of translational termination (GO:0006449)3.73999929
29mitotic sister chromatid segregation (GO:0000070)3.71048353
30negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.65322311
31protein complex localization (GO:0031503)3.64476833
32proline biosynthetic process (GO:0006561)3.62825893
33sister chromatid segregation (GO:0000819)3.61043457
34chromosome condensation (GO:0030261)3.52689015
35maturation of SSU-rRNA (GO:0030490)3.51909806
36regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.51525560
37telomere maintenance via semi-conservative replication (GO:0032201)3.50247206
38negative regulation of histone methylation (GO:0031061)3.50059751
39chromatin assembly (GO:0031497)3.49940369
40regulation of histone H3-K9 methylation (GO:0051570)3.48204635
41protein-DNA complex disassembly (GO:0032986)3.43588763
42nucleosome disassembly (GO:0006337)3.43588763
43spliceosomal tri-snRNP complex assembly (GO:0000244)3.42817783
44mitotic chromosome condensation (GO:0007076)3.40744547
45dosage compensation (GO:0007549)3.39998907
46peptidyl-arginine omega-N-methylation (GO:0035247)3.39090448
47establishment of integrated proviral latency (GO:0075713)3.39070630
48positive regulation of chromosome segregation (GO:0051984)3.38598455
49DNA replication checkpoint (GO:0000076)3.37520351
50cellular protein complex localization (GO:0034629)3.34625745
51nuclear envelope organization (GO:0006998)3.33778476
52ribosomal small subunit biogenesis (GO:0042274)3.33078651
53mitotic metaphase plate congression (GO:0007080)3.32376824
54regulation of mammary gland epithelial cell proliferation (GO:0033599)3.30407796
55purine nucleobase biosynthetic process (GO:0009113)3.30391475
56ribosome assembly (GO:0042255)3.29942122
57* nucleobase biosynthetic process (GO:0046112)3.28867158
58negative regulation of RNA splicing (GO:0033119)3.28845446
59regulation of spindle organization (GO:0090224)3.23964457
60ribosome biogenesis (GO:0042254)3.22782618
61negative regulation of mRNA processing (GO:0050686)3.20814296
62DNA synthesis involved in DNA repair (GO:0000731)3.16553785
63negative regulation of mRNA metabolic process (GO:1903312)3.16390373
64mitotic sister chromatid cohesion (GO:0007064)3.15947969
65histone H2A monoubiquitination (GO:0035518)3.13066998
66protein export from nucleus (GO:0006611)3.11534086
67L-serine metabolic process (GO:0006563)3.11112422
68regulation of nucleobase-containing compound transport (GO:0032239)3.10865925
69regulation of RNA export from nucleus (GO:0046831)3.08975916
70mitotic recombination (GO:0006312)3.08651545
71telomere maintenance via recombination (GO:0000722)3.07854747
72DNA conformation change (GO:0071103)3.05599155
73COPI coating of Golgi vesicle (GO:0048205)3.03712743
74Golgi transport vesicle coating (GO:0048200)3.03712743
75translational initiation (GO:0006413)3.02185636
76regulation of mitotic spindle organization (GO:0060236)3.02016867
77DNA packaging (GO:0006323)3.01593144
78somatic diversification of immune receptors via somatic mutation (GO:0002566)3.00002320
79somatic hypermutation of immunoglobulin genes (GO:0016446)3.00002320
80regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.99689467
81translesion synthesis (GO:0019985)2.99461877
82viral transcription (GO:0019083)2.98659142
83translational termination (GO:0006415)2.98420398
84regulation of sister chromatid cohesion (GO:0007063)2.98030736
85rRNA transcription (GO:0009303)2.97641997
86chromatin assembly or disassembly (GO:0006333)2.96966603
87mRNA transport (GO:0051028)2.95718984
88positive regulation of DNA-dependent DNA replication (GO:2000105)2.95129385
89metaphase plate congression (GO:0051310)2.94915348
90RNA stabilization (GO:0043489)2.94592641
91mRNA stabilization (GO:0048255)2.94592641
92telomere maintenance via telomere lengthening (GO:0010833)2.94417348
93nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.91968554
94ribonucleoprotein complex biogenesis (GO:0022613)2.91918366
95histone arginine methylation (GO:0034969)2.91786389
96viral mRNA export from host cell nucleus (GO:0046784)2.91542014
97regulation of DNA damage checkpoint (GO:2000001)2.91246854
98ribosomal small subunit assembly (GO:0000028)2.90893200
99regulation of histone H3-K27 methylation (GO:0061085)2.89757662
100peptidyl-arginine N-methylation (GO:0035246)2.89531471
101peptidyl-arginine methylation (GO:0018216)2.89531471
102protein localization to chromosome (GO:0034502)2.89238980
103mRNA splicing, via spliceosome (GO:0000398)2.88575674
104RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.88575674
105RNA splicing, via transesterification reactions (GO:0000375)2.88180503
106nucleotide-excision repair, DNA gap filling (GO:0006297)2.86985100
107tetrahydrofolate metabolic process (GO:0046653)2.84101406
108histone H4-K12 acetylation (GO:0043983)2.81812127
109snRNA processing (GO:0016180)2.81537724
110translational elongation (GO:0006414)2.81504181
111regulation of gene silencing (GO:0060968)2.80358466
112snRNA metabolic process (GO:0016073)2.80233218
113regulation of chromosome segregation (GO:0051983)2.78933430
114ribosomal large subunit biogenesis (GO:0042273)2.76799417
115paraxial mesoderm development (GO:0048339)2.76650080
116double-strand break repair via nonhomologous end joining (GO:0006303)2.75030136
117non-recombinational repair (GO:0000726)2.75030136
118planar cell polarity pathway involved in neural tube closure (GO:0090179)2.74991943
119regulation of translational elongation (GO:0006448)2.74540499
120regulation of helicase activity (GO:0051095)2.73198267
121mitotic G1 DNA damage checkpoint (GO:0031571)2.71872617
122rRNA processing (GO:0006364)2.71664437
123nucleic acid transport (GO:0050657)2.71295424
124RNA transport (GO:0050658)2.71295424
125establishment of RNA localization (GO:0051236)2.71295424
126alternative mRNA splicing, via spliceosome (GO:0000380)2.70489610
127glucocorticoid receptor signaling pathway (GO:0042921)2.67567784
128tRNA aminoacylation for protein translation (GO:0006418)2.62463003
129apoptotic process involved in morphogenesis (GO:0060561)2.62159180
130negative regulation of DNA repair (GO:0045738)2.62063620
131positive regulation of cell cycle checkpoint (GO:1901978)2.60108979
132folic acid metabolic process (GO:0046655)2.59905350
133V(D)J recombination (GO:0033151)2.59015334
134regulation of chromatin binding (GO:0035561)2.58717853

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.26135391
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.45957530
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.95002971
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.47021903
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.41089361
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.01155665
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90333664
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.87750488
9MYC_22102868_ChIP-Seq_BL_Human2.67951543
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55103708
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.30652012
12NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13522797
13XRN2_22483619_ChIP-Seq_HELA_Human2.12789023
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.07541295
15* E2F1_21310950_ChIP-Seq_MCF-7_Human2.00300039
16AR_21909140_ChIP-Seq_LNCAP_Human1.97787067
17ETS1_20019798_ChIP-Seq_JURKAT_Human1.91853904
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.88795865
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.87700870
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85188638
21POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80313188
22MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79854002
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76940164
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74723989
25NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74307808
26CIITA_25753668_ChIP-Seq_RAJI_Human1.71632091
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.70555133
28* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.68758069
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.62763236
30STAT3_1855785_ChIP-Seq_MESCs_Mouse1.60052977
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55820393
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.55479783
33VDR_23849224_ChIP-Seq_CD4+_Human1.53206667
34VDR_21846776_ChIP-Seq_THP-1_Human1.52835049
35TTF2_22483619_ChIP-Seq_HELA_Human1.51730525
36KDM5A_27292631_Chip-Seq_BREAST_Human1.51691337
37ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50439281
38FOXP3_21729870_ChIP-Seq_TREG_Human1.49851738
39* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48767796
40GABP_19822575_ChIP-Seq_HepG2_Human1.45637949
41KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.45623718
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.45623718
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.45623718
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.42946383
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.41591017
46KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.40943496
47DCP1A_22483619_ChIP-Seq_HELA_Human1.40343962
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39618926
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.38114694
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37649586
51KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36637744
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35551758
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34179160
54DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33279920
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33085180
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32194883
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30425090
58RACK7_27058665_Chip-Seq_MCF-7_Human1.30074824
59LXR_22292898_ChIP-Seq_THP-1_Human1.27249469
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25865731
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24603112
62TFEB_21752829_ChIP-Seq_HELA_Human1.24339513
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23129345
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22413983
65* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20607862
66TCF3_18692474_ChIP-Seq_MEFs_Mouse1.19549526
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19362764
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19012865
69HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16206181
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15632650
71ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14039798
72TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13359460
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10431068
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10365844
75NANOG_21062744_ChIP-ChIP_HESCs_Human1.10364390
76ZNF263_19887448_ChIP-Seq_K562_Human1.08652811
77* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07579281
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07189440
79NCOR1_26117541_ChIP-Seq_K562_Human1.06402650
80* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06216695
81CLOCK_20551151_ChIP-Seq_293T_Human1.05646822
82P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05180615
83ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05006925
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04693534
85ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04171686
86TCF7_22412390_ChIP-Seq_EML_Mouse1.04056386
87CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03859523
88TP63_17297297_ChIP-ChIP_HaCaT_Human1.02843020
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02356123
90* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01460237
91ELK1_19687146_ChIP-ChIP_HELA_Human1.01122552
92NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00913204
93SALL1_21062744_ChIP-ChIP_HESCs_Human1.00781405
94KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00620191
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99849899
96KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99110221
97TCF3_18692474_ChIP-Seq_MESCs_Mouse0.97179038
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96748926
99TET1_21451524_ChIP-Seq_MESCs_Mouse0.96381703
100CHD1_26751641_Chip-Seq_LNCaP_Human0.95625614
101SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.94846213
102YY1_21170310_ChIP-Seq_MESCs_Mouse0.94525306
103NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94393066
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93510082
105ATF3_27146783_Chip-Seq_COLON_Human0.92867913
106ELK3_25401928_ChIP-Seq_HUVEC_Human0.92697524
107SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92332189
108KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92253009
109UTX_26944678_Chip-Seq_JUKART_Human0.91319036
110PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.90698837
111* NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.90526038
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.90282151
113HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88889601
114PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88875600
115PKCTHETA_26484144_Chip-Seq_BREAST_Human0.88700471
116UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88545024
117FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88368475
118RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88278379
119* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87735126
120KDM2B_26808549_Chip-Seq_DND41_Human0.87503626
121ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86334637
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86002620
123* P68_20966046_ChIP-Seq_HELA_Human0.83705262
124WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.82955580

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.95616223
2MP0003693_abnormal_embryo_hatching3.89064368
3MP0010094_abnormal_chromosome_stability3.86463376
4MP0004957_abnormal_blastocyst_morpholog3.81338399
5MP0008057_abnormal_DNA_replication3.63572695
6MP0010352_gastrointestinal_tract_polyps3.43786232
7MP0003077_abnormal_cell_cycle3.35800762
8MP0001730_embryonic_growth_arrest2.61945581
9MP0003705_abnormal_hypodermis_morpholog2.42944089
10MP0005076_abnormal_cell_differentiation2.42914770
11MP0000350_abnormal_cell_proliferation2.36459908
12MP0003123_paternal_imprinting2.31512964
13MP0010307_abnormal_tumor_latency2.27709676
14MP0008058_abnormal_DNA_repair2.24086139
15MP0008007_abnormal_cellular_replicative2.23963893
16MP0002396_abnormal_hematopoietic_system2.20117729
17MP0005380_embryogenesis_phenotype2.08614917
18MP0001672_abnormal_embryogenesis/_devel2.08614917
19MP0008932_abnormal_embryonic_tissue2.04512082
20MP0004197_abnormal_fetal_growth/weight/1.98806072
21MP0002084_abnormal_developmental_patter1.97044614
22MP0001697_abnormal_embryo_size1.94047555
23MP0003984_embryonic_growth_retardation1.92311889
24MP0002088_abnormal_embryonic_growth/wei1.90268862
25MP0002085_abnormal_embryonic_tissue1.88922934
26MP0010030_abnormal_orbit_morphology1.83292562
27MP0002086_abnormal_extraembryonic_tissu1.82472983
28MP0002080_prenatal_lethality1.75730557
29MP0003890_abnormal_embryonic-extraembry1.67030470
30MP0000537_abnormal_urethra_morphology1.66588478
31MP0000490_abnormal_crypts_of1.60289717
32MP0004808_abnormal_hematopoietic_stem1.56303013
33MP0008877_abnormal_DNA_methylation1.49755752
34MP0003121_genomic_imprinting1.46691802
35MP0001661_extended_life_span1.46534789
36MP0003786_premature_aging1.46317579
37MP0005451_abnormal_body_composition1.42381258
38MP0000566_synostosis1.42132350
39MP0003119_abnormal_digestive_system1.41277276
40MP0000678_abnormal_parathyroid_gland1.40098304
41MP0003567_abnormal_fetal_cardiomyocyte1.40008343
42MP0003566_abnormal_cell_adhesion1.36540408
43MP0009278_abnormal_bone_marrow1.32230476
44MP0008438_abnormal_cutaneous_collagen1.32023069
45MP0001293_anophthalmia1.31420675
46MP0002877_abnormal_melanocyte_morpholog1.31333055
47MP0000313_abnormal_cell_death1.31017981
48MP0002019_abnormal_tumor_incidence1.28371104
49MP0001849_ear_inflammation1.27255721
50MP0004272_abnormal_basement_membrane1.26363219
51MP0009053_abnormal_anal_canal1.24120959
52MP0004858_abnormal_nervous_system1.23734366
53MP0002796_impaired_skin_barrier1.23681087
54MP0001348_abnormal_lacrimal_gland1.22350859
55MP0000579_abnormal_nail_morphology1.18276975
56MP0005257_abnormal_intraocular_pressure1.16151173
57MP0002653_abnormal_ependyma_morphology1.15544710
58MP0000703_abnormal_thymus_morphology1.13633243
59MP0009672_abnormal_birth_weight1.13370462
60MP0000428_abnormal_craniofacial_morphol1.12569419
61MP0002060_abnormal_skin_morphology1.12458760
62MP0005023_abnormal_wound_healing1.11476437
63MP0003315_abnormal_perineum_morphology1.10020724
64MP0002009_preneoplasia1.07996472
65MP0001915_intracranial_hemorrhage1.07186285
66MP0003385_abnormal_body_wall1.07150105
67MP0005397_hematopoietic_system_phenotyp1.06410345
68MP0001545_abnormal_hematopoietic_system1.06410345
69MP0003942_abnormal_urinary_system1.05857490
70MP0002111_abnormal_tail_morphology1.05590372
71MP0002249_abnormal_larynx_morphology1.03849787
72MP0000733_abnormal_muscle_development1.03775538
73MP0003763_abnormal_thymus_physiology1.01012231
74MP0003283_abnormal_digestive_organ1.00982491
75MP0009703_decreased_birth_body0.99533688
76MP0009333_abnormal_splenocyte_physiolog0.98522813
77MP0002697_abnormal_eye_size0.98268020
78MP0000003_abnormal_adipose_tissue0.98112981
79MP0009697_abnormal_copulation0.97575600
80MP0004264_abnormal_extraembryonic_tissu0.96543273
81MP0010234_abnormal_vibrissa_follicle0.94842443
82MP0002092_abnormal_eye_morphology0.94467441
83MP0003453_abnormal_keratinocyte_physiol0.93137296
84MP0001346_abnormal_lacrimal_gland0.92117957
85MP0006054_spinal_hemorrhage0.91703070
86MP0002925_abnormal_cardiovascular_devel0.88970068
87MP0003718_maternal_effect0.88080020
88MP0004133_heterotaxia0.86994326
89MP0003937_abnormal_limbs/digits/tail_de0.85848123
90MP0003115_abnormal_respiratory_system0.84757057
91MP0002722_abnormal_immune_system0.84634488
92MP0002398_abnormal_bone_marrow0.84485377
93MP0005621_abnormal_cell_physiology0.83940977
94MP0000762_abnormal_tongue_morphology0.83216501
95MP0000432_abnormal_head_morphology0.82298581
96MP0000477_abnormal_intestine_morphology0.81263017
97MP0004185_abnormal_adipocyte_glucose0.81142641
98MP0005384_cellular_phenotype0.80837471
99MP0002210_abnormal_sex_determination0.79795077
100MP0003935_abnormal_craniofacial_develop0.79688347
101MP0001145_abnormal_male_reproductive0.79581912
102MP0008260_abnormal_autophagy0.76746810
103MP0008770_decreased_survivor_rate0.76501146
104MP0004233_abnormal_muscle_weight0.76119266
105MP0003806_abnormal_nucleotide_metabolis0.75539001
106MP0005409_darkened_coat_color0.75272727
107MP0001216_abnormal_epidermal_layer0.74667819
108MP0010630_abnormal_cardiac_muscle0.74155910
109MP0003941_abnormal_skin_development0.73830877
110MP0003943_abnormal_hepatobiliary_system0.73559214
111MP0005666_abnormal_adipose_tissue0.73341891
112MP0000858_altered_metastatic_potential0.73165610
113MP0000689_abnormal_spleen_morphology0.72974403
114MP0000467_abnormal_esophagus_morphology0.71993396
115MP0001286_abnormal_eye_development0.70931098
116MP0002254_reproductive_system_inflammat0.70483165
117MP0003300_gastrointestinal_ulcer0.69991279
118MP0000358_abnormal_cell_content/0.69416012
119MP0002098_abnormal_vibrissa_morphology0.67451045
120MP0005623_abnormal_meninges_morphology0.66591171
121MP0003861_abnormal_nervous_system0.66358317
122MP0000266_abnormal_heart_morphology0.64634484
123MP0002932_abnormal_joint_morphology0.63665114
124MP0005501_abnormal_skin_physiology0.60145002
125MP0002114_abnormal_axial_skeleton0.59740305
126MP0000653_abnormal_sex_gland0.59413388
127MP0002429_abnormal_blood_cell0.58411197
128MP0002089_abnormal_postnatal_growth/wei0.56061923
129MP0001784_abnormal_fluid_regulation0.55446131
130MP0001929_abnormal_gametogenesis0.54105319
131MP0002075_abnormal_coat/hair_pigmentati0.52230680
132MP0000371_diluted_coat_color0.51413386

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.30945565
2Selective tooth agenesis (HP:0001592)3.58257012
3Medulloblastoma (HP:0002885)3.28395296
4Abnormality of the astrocytes (HP:0100707)3.19588568
5Astrocytoma (HP:0009592)3.19588568
6Colon cancer (HP:0003003)3.03384849
7Deviation of the thumb (HP:0009603)2.95494404
8Proximal placement of thumb (HP:0009623)2.91559751
9Reticulocytopenia (HP:0001896)2.79493395
10Basal cell carcinoma (HP:0002671)2.77793036
11Missing ribs (HP:0000921)2.77118755
12Insomnia (HP:0100785)2.75335781
13Rhabdomyosarcoma (HP:0002859)2.70021664
14Neoplasm of the oral cavity (HP:0100649)2.69770035
15Birth length less than 3rd percentile (HP:0003561)2.69148066
16Abnormality of the anterior horn cell (HP:0006802)2.64963453
17Degeneration of anterior horn cells (HP:0002398)2.64963453
18Glioma (HP:0009733)2.59715021
19Chromsome breakage (HP:0040012)2.57183749
20Abnormal number of incisors (HP:0011064)2.57122487
21Progressive muscle weakness (HP:0003323)2.56535673
22Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.56502522
23Short 4th metacarpal (HP:0010044)2.56502522
24Neoplasm of striated muscle (HP:0009728)2.54292546
25Increased nuchal translucency (HP:0010880)2.49660554
26Abnormality of the labia minora (HP:0012880)2.48094883
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.41692379
28Urethral obstruction (HP:0000796)2.38968759
29Patellar aplasia (HP:0006443)2.35893599
30Ankyloglossia (HP:0010296)2.35299567
31Disproportionate tall stature (HP:0001519)2.33793622
32Premature rupture of membranes (HP:0001788)2.33463403
33Broad face (HP:0000283)2.32685548
34High anterior hairline (HP:0009890)2.29443024
35Abnormality of cells of the erythroid lineage (HP:0012130)2.28430534
36Abnormality of oral frenula (HP:0000190)2.27336615
37Microvesicular hepatic steatosis (HP:0001414)2.26741286
38Impulsivity (HP:0100710)2.26447687
39Hyperacusis (HP:0010780)2.26209011
40Overriding aorta (HP:0002623)2.24928966
41Absent radius (HP:0003974)2.24753933
42Elfin facies (HP:0004428)2.22238453
43Asymmetry of the thorax (HP:0001555)2.21728998
44Prominent nose (HP:0000448)2.21635533
45Agnosia (HP:0010524)2.21037584
46Facial hemangioma (HP:0000329)2.20990098
47Aplasia/hypoplasia of the humerus (HP:0006507)2.20444841
4811 pairs of ribs (HP:0000878)2.20199686
49Abnormality of the calcaneus (HP:0008364)2.18938363
50Trismus (HP:0000211)2.18880078
51Aplasia/Hypoplasia of the patella (HP:0006498)2.18413038
52Absent thumb (HP:0009777)2.18213385
53Long palpebral fissure (HP:0000637)2.18007895
54Rib fusion (HP:0000902)2.17391943
55Short humerus (HP:0005792)2.15771974
56High pitched voice (HP:0001620)2.15470916
57Breast hypoplasia (HP:0003187)2.14806358
58Pseudobulbar signs (HP:0002200)2.13088837
59Broad distal phalanx of finger (HP:0009836)2.12722339
60Atresia of the external auditory canal (HP:0000413)2.11345580
61Neoplasm of the pancreas (HP:0002894)2.07858169
62Abnormal number of erythroid precursors (HP:0012131)2.07536238
63Abnormality of chromosome stability (HP:0003220)2.07455336
64Abnormality of the distal phalanx of the thumb (HP:0009617)2.07306127
65Dysmetric saccades (HP:0000641)2.07245853
66Aplasia involving forearm bones (HP:0009822)2.06922397
67Absent forearm bone (HP:0003953)2.06922397
68Skin tags (HP:0010609)2.06564066
69Volvulus (HP:0002580)2.06136473
70Shallow orbits (HP:0000586)2.04332987
71Ectopic kidney (HP:0000086)2.04156685
72Long eyelashes (HP:0000527)2.04067949
73Squamous cell carcinoma (HP:0002860)2.02902198
74Cafe-au-lait spot (HP:0000957)2.02582782
75Renal duplication (HP:0000075)2.02185801
76Abnormality of cochlea (HP:0000375)2.01697812
77Myelodysplasia (HP:0002863)2.01325920
78Gastrointestinal carcinoma (HP:0002672)2.00887090
79Malignant gastrointestinal tract tumors (HP:0006749)2.00887090
80Abnormality of reticulocytes (HP:0004312)1.99304686
81Skull defect (HP:0001362)1.99105215
82Amaurosis fugax (HP:0100576)1.96579432
83Pointed chin (HP:0000307)1.95751586
84Duplication of thumb phalanx (HP:0009942)1.95384008
85Preauricular skin tag (HP:0000384)1.95294222
86Meckel diverticulum (HP:0002245)1.94040243
87Biliary tract neoplasm (HP:0100574)1.93996443
88Oral leukoplakia (HP:0002745)1.92440911
89Progressive external ophthalmoplegia (HP:0000590)1.92194677
90Multiple enchondromatosis (HP:0005701)1.90157130
91Premature skin wrinkling (HP:0100678)1.89907625
92Patellar dislocation (HP:0002999)1.89802647
93Abnormality of the ileum (HP:0001549)1.89727172
94Increased density of long bones (HP:0006392)1.89078117
95Overlapping toe (HP:0001845)1.88534648
96Adenoma sebaceum (HP:0009720)1.86290901
97Angiofibromas (HP:0010615)1.86290901
98Broad palm (HP:0001169)1.85535657
99Biconcave vertebral bodies (HP:0004586)1.84390001
100Spinal muscular atrophy (HP:0007269)1.84299869
101Cholecystitis (HP:0001082)1.83645411
102Abnormal gallbladder physiology (HP:0012438)1.83645411
103Renovascular hypertension (HP:0100817)1.83600858
104Poikiloderma (HP:0001029)1.83538113
105Aplasia/Hypoplasia of the uvula (HP:0010293)1.83508700
106Ankle contracture (HP:0006466)1.82462690
107Esophageal atresia (HP:0002032)1.82379273
108Carpal bone hypoplasia (HP:0001498)1.82192538
109Ulnar bowing (HP:0003031)1.81067786
110Deep philtrum (HP:0002002)1.80675157
111Abdominal situs inversus (HP:0003363)1.79347326
112Abnormality of abdominal situs (HP:0011620)1.79347326
113Supernumerary ribs (HP:0005815)1.79329212
114Broad thumb (HP:0011304)1.78183746
115Aplasia/Hypoplasia of the sternum (HP:0006714)1.77609244
116Abnormality of the 4th metacarpal (HP:0010012)1.77417409
117Deep palmar crease (HP:0006191)1.76940393
118Cutaneous melanoma (HP:0012056)1.76922224
119Spastic diplegia (HP:0001264)1.76672208
120Achilles tendon contracture (HP:0001771)1.75895397
121Rough bone trabeculation (HP:0100670)1.75607131
122Tracheoesophageal fistula (HP:0002575)1.75418479
123Abnormality of the fingertips (HP:0001211)1.75290931
124Abnormality of the preputium (HP:0100587)1.75081193
125Supernumerary bones of the axial skeleton (HP:0009144)1.74933549
126Natal tooth (HP:0000695)1.74041552
127Nephroblastoma (Wilms tumor) (HP:0002667)1.73679084
128Genu recurvatum (HP:0002816)1.72647373
129Reticulocytosis (HP:0001923)1.72096171
130Flat cornea (HP:0007720)1.71830100
131Septate vagina (HP:0001153)1.71625996
132Sandal gap (HP:0001852)1.70882634
133Small intestinal stenosis (HP:0012848)1.70704338
134Duodenal stenosis (HP:0100867)1.70704338
135Trigonocephaly (HP:0000243)1.70380436
136Protrusio acetabuli (HP:0003179)1.69766260
137Atrophy/Degeneration involving motor neurons (HP:0007373)1.68715547
138Hand muscle atrophy (HP:0009130)1.68592951
139Hypoplasia of the capital femoral epiphysis (HP:0003090)1.68531695
140Abnormality of the carotid arteries (HP:0005344)1.68459576
141Advanced eruption of teeth (HP:0006288)1.68069310
142Heterotopia (HP:0002282)1.68010038
143Supernumerary spleens (HP:0009799)1.67483843
144Abnormality of the salivary glands (HP:0010286)1.63659893
145Arnold-Chiari malformation (HP:0002308)1.63165070
146Choanal atresia (HP:0000453)1.61853087
147Distal upper limb amyotrophy (HP:0007149)1.61511160
148Upper limb amyotrophy (HP:0009129)1.61511160
149Obsessive-compulsive behavior (HP:0000722)1.60704094
150Increased connective tissue (HP:0009025)1.59661429
151Glossoptosis (HP:0000162)1.57832471
152Horseshoe kidney (HP:0000085)1.57647962
153Flat acetabular roof (HP:0003180)1.57613302
154Turricephaly (HP:0000262)1.57381239
155Relative macrocephaly (HP:0004482)1.56532186
156Abnormality of the umbilical cord (HP:0010881)1.56210519
157Embryonal renal neoplasm (HP:0011794)1.56011336
158Spinal cord lesions (HP:0100561)1.55883848
159Syringomyelia (HP:0003396)1.55883848
160Dislocated radial head (HP:0003083)1.55580389
161Distal lower limb amyotrophy (HP:0008944)1.55120169

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.53780797
2CDK124.31763215
3EEF2K4.03092046
4CDC74.03041829
5WEE12.80700965
6NEK22.62492513
7BUB12.54338223
8TSSK62.47757308
9MAP3K102.46152885
10PASK2.43473256
11PKN22.42303373
12TTK2.12438574
13RPS6KB22.10399690
14TRIB32.08728012
15SCYL21.95470933
16EPHA21.91506141
17CDK71.82198320
18IRAK31.82083723
19CDK41.74527088
20NEK11.68955625
21BRD41.68484963
22PRPF4B1.58956424
23STK101.56451599
24ATR1.55908817
25MST1R1.55665290
26ALK1.54431728
27FGFR41.54357816
28VRK21.54076267
29MAP3K81.52485007
30PLK11.48974559
31CHEK11.43755580
32TAF11.40151788
33MTOR1.37056425
34ICK1.32261534
35AURKB1.31530031
36TGFBR11.29338459
37MAP4K11.27245745
38SRPK11.26653645
39MKNK11.26126089
40PAK41.24514124
41CHEK21.23025942
42TTN1.17039127
43RPS6KA41.16966628
44FLT31.13888938
45PBK1.08938863
46CDK61.08029972
47TESK21.06528136
48BRSK21.04670872
49TLK11.03384407
50PLK31.03102782
51EIF2AK11.01548606
52CDK21.00898681
53PIM10.98662011
54CDK80.98072552
55ATM0.97800088
56LRRK20.97033895
57PAK20.95891445
58STK40.95774970
59LATS10.93181490
60CAMK1G0.93107692
61NME20.92296407
62AURKA0.92086612
63PDGFRA0.89701255
64MKNK20.87980260
65STK30.86673191
66BMX0.85135309
67PTK60.85115326
68ACVR1B0.83892371
69PTK20.80070031
70DYRK30.78464897
71MAPK110.75449220
72NME10.74103280
73JAK30.73325604
74MAP2K30.72137121
75LATS20.69303116
76FGFR10.68227304
77CDK10.67902836
78GRK60.63729782
79AKT20.63724541
80BRAF0.63392360
81CSNK2A20.61784132
82PNCK0.61208294
83PRKD30.60876793
84CSNK1E0.59609731
85NTRK10.59162236
86KSR20.58918982
87VRK10.58440339
88PAK10.58079770
89MAP3K90.56890166
90PLK40.55985289
91BRSK10.55163911
92EIF2AK30.54941522
93MELK0.54072035
94CSNK1D0.51869709
95PRKDC0.51196943
96CDK90.50373605
97PRKCI0.49558739
98CAMK1D0.46469325
99MAP3K130.45266941
100MAP2K20.44940031
101MAPK140.44363246
102MAP3K110.43234838
103ZAP700.43107034
104PIM20.42087676
105CHUK0.41008920
106RAF10.40757989
107RPS6KA10.40045706
108SIK10.39921711
109MET0.39295294
110ERN10.39186391
111CLK10.38847611
112MAPKAPK30.38693226
113LMTK20.37982242
114TYRO30.37852299
115EIF2AK20.37321028
116MAP3K30.37150597
117CDK11A0.36510105
118BTK0.36489137
119* MAPK10.36081131
120AKT10.36063564
121CSNK2A10.35734540
122RPS6KL10.35310813
123TAOK20.35175071
124RIPK10.35034724
125ERBB40.34350963
126CDK150.32590255
127GSK3B0.31018146
128RPS6KC10.30706524
129ILK0.29132486

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.51532733
2Mismatch repair_Homo sapiens_hsa034303.83816515
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.56727817
4One carbon pool by folate_Homo sapiens_hsa006703.43397247
5RNA transport_Homo sapiens_hsa030133.39185331
6Spliceosome_Homo sapiens_hsa030403.22236576
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.92036607
8Base excision repair_Homo sapiens_hsa034102.77610313
9Cell cycle_Homo sapiens_hsa041102.70985814
10Nucleotide excision repair_Homo sapiens_hsa034202.47857955
11Homologous recombination_Homo sapiens_hsa034402.26503768
12mRNA surveillance pathway_Homo sapiens_hsa030152.21863401
13Ribosome_Homo sapiens_hsa030102.21839805
14RNA polymerase_Homo sapiens_hsa030202.06324365
15Fanconi anemia pathway_Homo sapiens_hsa034601.76667547
16Non-homologous end-joining_Homo sapiens_hsa034501.69712567
17RNA degradation_Homo sapiens_hsa030181.67556268
18p53 signaling pathway_Homo sapiens_hsa041151.62274737
19* Pyrimidine metabolism_Homo sapiens_hsa002401.48777988
20Viral carcinogenesis_Homo sapiens_hsa052031.42609545
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.40001746
22Systemic lupus erythematosus_Homo sapiens_hsa053221.29886691
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24824767
24MicroRNAs in cancer_Homo sapiens_hsa052061.21815297
25Proteasome_Homo sapiens_hsa030501.20151473
26Vitamin B6 metabolism_Homo sapiens_hsa007501.19586968
27HTLV-I infection_Homo sapiens_hsa051661.17314219
28Basal transcription factors_Homo sapiens_hsa030221.17253482
29Selenocompound metabolism_Homo sapiens_hsa004501.16151347
30Epstein-Barr virus infection_Homo sapiens_hsa051691.15265545
31Chronic myeloid leukemia_Homo sapiens_hsa052201.09682844
32Antigen processing and presentation_Homo sapiens_hsa046121.09014629
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07818569
34Thyroid cancer_Homo sapiens_hsa052161.07517121
35Small cell lung cancer_Homo sapiens_hsa052221.06919845
36Biosynthesis of amino acids_Homo sapiens_hsa012301.06597805
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03967453
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.03064887
39Notch signaling pathway_Homo sapiens_hsa043301.01780731
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.99294710
41Basal cell carcinoma_Homo sapiens_hsa052170.96166344
42Herpes simplex infection_Homo sapiens_hsa051680.95979835
43Central carbon metabolism in cancer_Homo sapiens_hsa052300.94299666
44mTOR signaling pathway_Homo sapiens_hsa041500.93191711
45Hippo signaling pathway_Homo sapiens_hsa043900.91770981
46Lysine degradation_Homo sapiens_hsa003100.89897240
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87719559
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87556157
49Oocyte meiosis_Homo sapiens_hsa041140.86499463
50Glioma_Homo sapiens_hsa052140.86276838
51Bladder cancer_Homo sapiens_hsa052190.85020413
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84068669
53Galactose metabolism_Homo sapiens_hsa000520.80769401
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79574064
55Adherens junction_Homo sapiens_hsa045200.78332628
56Colorectal cancer_Homo sapiens_hsa052100.78267033
57Acute myeloid leukemia_Homo sapiens_hsa052210.77311313
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.75545814
59TGF-beta signaling pathway_Homo sapiens_hsa043500.74208810
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69036871
61Purine metabolism_Homo sapiens_hsa002300.66831273
62ErbB signaling pathway_Homo sapiens_hsa040120.66593127
63Pentose phosphate pathway_Homo sapiens_hsa000300.66081852
64Viral myocarditis_Homo sapiens_hsa054160.65952804
65Hedgehog signaling pathway_Homo sapiens_hsa043400.64551808
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62758786
67Apoptosis_Homo sapiens_hsa042100.62532486
68Legionellosis_Homo sapiens_hsa051340.62427339
69Pyruvate metabolism_Homo sapiens_hsa006200.62272093
70Insulin signaling pathway_Homo sapiens_hsa049100.61816002
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61198179
72Non-small cell lung cancer_Homo sapiens_hsa052230.61098669
73Proteoglycans in cancer_Homo sapiens_hsa052050.60011238
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58468059
75Prostate cancer_Homo sapiens_hsa052150.56820565
76Hepatitis B_Homo sapiens_hsa051610.56766384
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56505294
78Pathways in cancer_Homo sapiens_hsa052000.54489557
79HIF-1 signaling pathway_Homo sapiens_hsa040660.54396804
80ECM-receptor interaction_Homo sapiens_hsa045120.52572708
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51008601
82Alcoholism_Homo sapiens_hsa050340.50919115
83Endometrial cancer_Homo sapiens_hsa052130.48741096
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48171656
85Prion diseases_Homo sapiens_hsa050200.47723416
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.47599207
87Primary immunodeficiency_Homo sapiens_hsa053400.46874412
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45510207
89N-Glycan biosynthesis_Homo sapiens_hsa005100.43562405
90Other glycan degradation_Homo sapiens_hsa005110.43222695
91Measles_Homo sapiens_hsa051620.43074175
92Inositol phosphate metabolism_Homo sapiens_hsa005620.41720553
93Steroid biosynthesis_Homo sapiens_hsa001000.40357078
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40073600
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.38838000
96Pancreatic cancer_Homo sapiens_hsa052120.38613504
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.38362091
98Tight junction_Homo sapiens_hsa045300.37990830
99Carbon metabolism_Homo sapiens_hsa012000.37960470
100Arginine biosynthesis_Homo sapiens_hsa002200.37367692
101Wnt signaling pathway_Homo sapiens_hsa043100.36127073
102Shigellosis_Homo sapiens_hsa051310.35979427
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35812414
104T cell receptor signaling pathway_Homo sapiens_hsa046600.35267925
105Focal adhesion_Homo sapiens_hsa045100.35133607
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34333432
107Fructose and mannose metabolism_Homo sapiens_hsa000510.33698510
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32806751
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31690182
110Sulfur relay system_Homo sapiens_hsa041220.31225089
111B cell receptor signaling pathway_Homo sapiens_hsa046620.30267025
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.30175414
113Melanoma_Homo sapiens_hsa052180.29388570
114VEGF signaling pathway_Homo sapiens_hsa043700.29077957
115AMPK signaling pathway_Homo sapiens_hsa041520.29012653
116Renal cell carcinoma_Homo sapiens_hsa052110.27008596
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26501649
118Influenza A_Homo sapiens_hsa051640.26381887
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25574611
120Toxoplasmosis_Homo sapiens_hsa051450.24566003
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24139760

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