CADM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.81997583
2vocalization behavior (GO:0071625)5.58666015
3sodium ion export (GO:0071436)5.58092893
4locomotory exploration behavior (GO:0035641)5.47816692
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.24806018
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.23940530
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.18139152
8synaptic vesicle exocytosis (GO:0016079)5.12018659
9ionotropic glutamate receptor signaling pathway (GO:0035235)5.06052964
10regulation of glutamate receptor signaling pathway (GO:1900449)4.83183668
11protein localization to synapse (GO:0035418)4.80680160
12glutamate receptor signaling pathway (GO:0007215)4.78061120
13glutamate secretion (GO:0014047)4.75991441
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.64755139
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.61716108
16exploration behavior (GO:0035640)4.59499187
17presynaptic membrane assembly (GO:0097105)4.47108801
18regulation of synaptic vesicle exocytosis (GO:2000300)4.39444768
19neuronal action potential propagation (GO:0019227)4.37291890
20cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.36768370
21synaptic vesicle maturation (GO:0016188)4.34129863
22neuron-neuron synaptic transmission (GO:0007270)4.33253389
23synaptic transmission, glutamatergic (GO:0035249)4.33086463
24neuron recognition (GO:0008038)4.30646127
25gamma-aminobutyric acid signaling pathway (GO:0007214)4.14624262
26regulation of long-term neuronal synaptic plasticity (GO:0048169)4.11725383
27presynaptic membrane organization (GO:0097090)4.05517992
28amino acid import (GO:0043090)4.03508848
29neurotransmitter-gated ion channel clustering (GO:0072578)4.02402258
30central nervous system myelination (GO:0022010)4.01581184
31axon ensheathment in central nervous system (GO:0032291)4.01581184
32potassium ion import (GO:0010107)4.00045334
33negative regulation of synaptic transmission, GABAergic (GO:0032229)3.98330273
34potassium ion homeostasis (GO:0055075)3.92988477
35cellular sodium ion homeostasis (GO:0006883)3.91383179
36regulation of synaptic vesicle transport (GO:1902803)3.91355760
37postsynaptic membrane organization (GO:0001941)3.89144322
38neurotransmitter secretion (GO:0007269)3.87557894
39axonal fasciculation (GO:0007413)3.84953452
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.84565096
41long-term synaptic potentiation (GO:0060291)3.83957824
42membrane depolarization during action potential (GO:0086010)3.81511905
43regulation of neuronal synaptic plasticity (GO:0048168)3.81098615
44cell communication by electrical coupling (GO:0010644)3.81061026
45dendritic spine morphogenesis (GO:0060997)3.79951897
46gamma-aminobutyric acid transport (GO:0015812)3.78353867
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.75859174
48regulation of postsynaptic membrane potential (GO:0060078)3.70743894
49transmission of nerve impulse (GO:0019226)3.70276925
50synaptic vesicle docking involved in exocytosis (GO:0016081)3.70167749
51mechanosensory behavior (GO:0007638)3.70030425
52G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.69962337
53long-term memory (GO:0007616)3.69531852
54response to histamine (GO:0034776)3.69143720
55positive regulation of synapse maturation (GO:0090129)3.67418141
56neurotransmitter uptake (GO:0001504)3.65859508
57regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.62925507
58layer formation in cerebral cortex (GO:0021819)3.60590911
59regulation of synapse structural plasticity (GO:0051823)3.57475557
60regulation of synaptic transmission, glutamatergic (GO:0051966)3.54952608
61regulation of dendritic spine morphogenesis (GO:0061001)3.54655294
62startle response (GO:0001964)3.51927929
63pyrimidine nucleobase catabolic process (GO:0006208)3.51764581
64positive regulation of membrane potential (GO:0045838)3.50898391
65regulation of synaptic plasticity (GO:0048167)3.50422024
66neuronal ion channel clustering (GO:0045161)3.46458180
67cellular potassium ion homeostasis (GO:0030007)3.38855776
68positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.38841267
69positive regulation of potassium ion transmembrane transport (GO:1901381)3.33802236
70neuromuscular process controlling balance (GO:0050885)3.33542735
71neurotransmitter transport (GO:0006836)3.32519961
72membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.31565015
73behavioral defense response (GO:0002209)3.29782327
74behavioral fear response (GO:0001662)3.29782327
75regulation of vesicle fusion (GO:0031338)3.29000351
76cerebellar granule cell differentiation (GO:0021707)3.28946444
77positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.27410973
78synapse assembly (GO:0007416)3.27318429
79C4-dicarboxylate transport (GO:0015740)3.25488452
80cell communication involved in cardiac conduction (GO:0086065)3.25232196
81regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.24117260
82synaptic vesicle endocytosis (GO:0048488)3.22454974
83adult walking behavior (GO:0007628)3.22385255
84regulation of dendritic spine development (GO:0060998)3.21612233
85positive regulation of synapse assembly (GO:0051965)3.19540434
86learning (GO:0007612)3.18734622
87acidic amino acid transport (GO:0015800)3.18702158
88fear response (GO:0042596)3.17773310
89behavioral response to cocaine (GO:0048148)3.13430498
90regulation of neurotransmitter secretion (GO:0046928)3.12047481
91negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.09538216
92membrane depolarization (GO:0051899)3.09287127
93innervation (GO:0060384)3.08300699
94regulation of neurotransmitter levels (GO:0001505)3.08035652
95regulation of glutamate secretion (GO:0014048)3.06313809
96detection of calcium ion (GO:0005513)3.04688654
97positive regulation of neurotransmitter secretion (GO:0001956)3.03885713
98membrane hyperpolarization (GO:0060081)3.02798406
99negative regulation of neurotransmitter transport (GO:0051589)3.02042847
100neuromuscular process (GO:0050905)3.01807816
101serotonin metabolic process (GO:0042428)3.01519227
102positive regulation of dendritic spine development (GO:0060999)2.99502129
103dendrite morphogenesis (GO:0048813)2.98179637
104auditory behavior (GO:0031223)2.96680835
105synapse organization (GO:0050808)2.95654910
106L-amino acid import (GO:0043092)2.95428058
107regulation of synapse maturation (GO:0090128)2.95042488
108intraspecies interaction between organisms (GO:0051703)2.93461181
109social behavior (GO:0035176)2.93461181
110proline transport (GO:0015824)2.92944585
111G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.92730717
112synaptic transmission (GO:0007268)2.92237442
113positive regulation of synaptic transmission (GO:0050806)2.90490369
114positive regulation of neurotransmitter transport (GO:0051590)2.90030052
115regulation of synaptic transmission (GO:0050804)2.89785500
116long term synaptic depression (GO:0060292)2.89679892
117central nervous system projection neuron axonogenesis (GO:0021952)2.89534489
118regulation of neurotransmitter transport (GO:0051588)2.89250839
119cerebellar Purkinje cell differentiation (GO:0021702)2.89088697
120positive regulation of dendritic spine morphogenesis (GO:0061003)2.88701784
121response to auditory stimulus (GO:0010996)2.86912588
122regulation of voltage-gated calcium channel activity (GO:1901385)2.85843488
123prepulse inhibition (GO:0060134)2.85389359
124dendritic spine organization (GO:0097061)2.83046822

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.93746562
2GBX2_23144817_ChIP-Seq_PC3_Human4.20921282
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10850002
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04306943
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98706171
6* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60394036
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52685835
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52685835
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51091493
10* REST_21632747_ChIP-Seq_MESCs_Mouse2.46655476
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.46594732
12TAF15_26573619_Chip-Seq_HEK293_Human2.44901942
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44071514
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.43705481
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37897310
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32404152
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.29686215
18DROSHA_22980978_ChIP-Seq_HELA_Human2.13692937
19* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12486627
20* RARB_27405468_Chip-Seq_BRAIN_Mouse2.12366593
21* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11391304
22AR_21572438_ChIP-Seq_LNCaP_Human2.11064301
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06810999
24* EZH2_27294783_Chip-Seq_ESCs_Mouse2.05485365
25* RNF2_27304074_Chip-Seq_ESCs_Mouse2.05287213
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04657273
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.01385495
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.92105457
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91599304
30* SMAD4_21799915_ChIP-Seq_A2780_Human1.81389757
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79878034
32* P300_19829295_ChIP-Seq_ESCs_Human1.75415371
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74921379
34* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73330793
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73270953
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71200003
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.66672224
38FUS_26573619_Chip-Seq_HEK293_Human1.63193912
39* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59095737
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58832391
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.55082274
42ZNF274_21170338_ChIP-Seq_K562_Hela1.54151243
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.51751421
44* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50385816
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.49295627
46* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48181347
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46647956
48RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.44701048
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.43944289
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43336463
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43015438
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42797247
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39997436
54IGF1R_20145208_ChIP-Seq_DFB_Human1.38207285
55AR_25329375_ChIP-Seq_VCAP_Human1.37770813
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36949317
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.36160681
58VDR_22108803_ChIP-Seq_LS180_Human1.33629170
59STAT3_23295773_ChIP-Seq_U87_Human1.32814940
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26466646
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25906592
62TP53_16413492_ChIP-PET_HCT116_Human1.22415803
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.22274160
64* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22121989
65* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21623026
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21489237
67* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19290790
68* RNF2_27304074_Chip-Seq_NSC_Mouse1.19024998
69* RING1B_27294783_Chip-Seq_ESCs_Mouse1.18008042
70* TCF4_23295773_ChIP-Seq_U87_Human1.17351324
71ER_23166858_ChIP-Seq_MCF-7_Human1.16956068
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.16072879
73* PRDM14_20953172_ChIP-Seq_ESCs_Human1.13872748
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13310000
75AR_19668381_ChIP-Seq_PC3_Human1.13216638
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12719535
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12719535
78TP53_18474530_ChIP-ChIP_U2OS_Human1.12287654
79* RUNX2_22187159_ChIP-Seq_PCA_Human1.11763890
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10901346
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.09679887
82P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09543831
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07841523
84LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07759832
85AHR_22903824_ChIP-Seq_MCF-7_Human1.07419129
86JUN_21703547_ChIP-Seq_K562_Human1.06921245
87BCAT_22108803_ChIP-Seq_LS180_Human1.06644078
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06099509
89EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06031113
90* SOX9_26525672_Chip-Seq_HEART_Mouse1.05642764
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05267742
92RING1B_27294783_Chip-Seq_NPCs_Mouse1.03593066
93* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03267511
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99031406
95WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98466675
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97752090
97GATA1_26923725_Chip-Seq_HPCs_Mouse0.95275389
98RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94724420
99E2F1_18555785_Chip-Seq_ESCs_Mouse0.94515327
100CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93982594
101KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93116483
102CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92868305
103TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92848848
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92415243
105RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92360231
106* KDM2B_26808549_Chip-Seq_REH_Human0.91686802
107SMAD3_21741376_ChIP-Seq_ESCs_Human0.91274639
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90912829
109DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90281305
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90115356
111STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89279087
112SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88672185

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.83551241
2MP0003880_abnormal_central_pattern5.70474929
3MP0003635_abnormal_synaptic_transmissio4.02385085
4MP0004270_analgesia3.54684579
5MP0009745_abnormal_behavioral_response3.44799831
6MP0002063_abnormal_learning/memory/cond3.26445180
7MP0002064_seizures3.17777952
8MP0009046_muscle_twitch3.05366248
9MP0001968_abnormal_touch/_nociception2.99110503
10MP0002572_abnormal_emotion/affect_behav2.92161387
11MP0001486_abnormal_startle_reflex2.70451635
12MP0005423_abnormal_somatic_nervous2.68188217
13MP0002272_abnormal_nervous_system2.66179995
14MP0002734_abnormal_mechanical_nocicepti2.44920643
15MP0002736_abnormal_nociception_after2.43989257
16MP0001440_abnormal_grooming_behavior2.40275543
17MP0001501_abnormal_sleep_pattern2.39034808
18MP0002822_catalepsy2.33230891
19MP0002735_abnormal_chemical_nociception2.32896250
20MP0002067_abnormal_sensory_capabilities2.06170703
21MP0000778_abnormal_nervous_system2.04962778
22MP0001529_abnormal_vocalization2.04377847
23MP0003329_amyloid_beta_deposits1.97177851
24MP0002733_abnormal_thermal_nociception1.95075780
25MP0006276_abnormal_autonomic_nervous1.89378714
26MP0005386_behavior/neurological_phenoty1.86912206
27MP0004924_abnormal_behavior1.86912206
28MP0002184_abnormal_innervation1.83924329
29MP0001970_abnormal_pain_threshold1.83491635
30MP0002557_abnormal_social/conspecific_i1.76881131
31MP0001188_hyperpigmentation1.75824526
32MP0009780_abnormal_chondrocyte_physiolo1.74109871
33MP0001984_abnormal_olfaction1.70765767
34MP0001905_abnormal_dopamine_level1.63141734
35MP0008569_lethality_at_weaning1.62995979
36MP0005646_abnormal_pituitary_gland1.62780258
37MP0005551_abnormal_eye_electrophysiolog1.51048386
38MP0002882_abnormal_neuron_morphology1.45597543
39MP0000955_abnormal_spinal_cord1.44797424
40MP0004811_abnormal_neuron_physiology1.44662237
41MP0002066_abnormal_motor_capabilities/c1.41703676
42MP0004885_abnormal_endolymph1.41468416
43MP0003879_abnormal_hair_cell1.38731110
44MP0002909_abnormal_adrenal_gland1.34716067
45MP0004858_abnormal_nervous_system1.34059069
46MP0004142_abnormal_muscle_tone1.32153205
47MP0004742_abnormal_vestibular_system1.29462524
48MP0002837_dystrophic_cardiac_calcinosis1.29035654
49MP0001502_abnormal_circadian_rhythm1.28047269
50MP0005409_darkened_coat_color1.22513267
51MP0003633_abnormal_nervous_system1.19322163
52MP0005645_abnormal_hypothalamus_physiol1.18921499
53MP0003787_abnormal_imprinting1.17304866
54MP0004145_abnormal_muscle_electrophysio1.14500588
55MP0002152_abnormal_brain_morphology1.11777213
56MP0003631_nervous_system_phenotype1.09527548
57MP0002229_neurodegeneration1.08289268
58MP0004147_increased_porphyrin_level1.03572915
59MP0001963_abnormal_hearing_physiology0.99902894
60MP0008872_abnormal_physiological_respon0.99091079
61MP0000920_abnormal_myelination0.96192441
62MP0003122_maternal_imprinting0.92508640
63MP0002752_abnormal_somatic_nervous0.92023971
64MP0003632_abnormal_nervous_system0.90596444
65MP0001485_abnormal_pinna_reflex0.90385964
66MP0000631_abnormal_neuroendocrine_gland0.90218816
67MP0003634_abnormal_glial_cell0.89559615
68MP0002069_abnormal_eating/drinking_beha0.88570803
69MP0003690_abnormal_glial_cell0.88128723
70MP0010386_abnormal_urinary_bladder0.87966327
71MP0000604_amyloidosis0.86151728
72MP0002090_abnormal_vision0.84779533
73MP0004215_abnormal_myocardial_fiber0.84301484
74MP0008874_decreased_physiological_sensi0.81846218
75MP0005187_abnormal_penis_morphology0.81766669
76MP0005535_abnormal_body_temperature0.81420130
77MP0004085_abnormal_heartbeat0.80308054
78MP0001986_abnormal_taste_sensitivity0.80256889
79MP0003123_paternal_imprinting0.79965563
80MP0002876_abnormal_thyroid_physiology0.78905877
81MP0000751_myopathy0.78537164
82MP0001177_atelectasis0.78460659
83MP0004484_altered_response_of0.76270379
84MP0006072_abnormal_retinal_apoptosis0.75304677
85MP0008877_abnormal_DNA_methylation0.75008372
86MP0005394_taste/olfaction_phenotype0.75003382
87MP0005499_abnormal_olfactory_system0.75003382
88MP0003121_genomic_imprinting0.74642577
89MP0000013_abnormal_adipose_tissue0.73285008
90MP0005171_absent_coat_pigmentation0.72688712
91MP0001346_abnormal_lacrimal_gland0.70165328
92MP0005253_abnormal_eye_physiology0.68305344
93MP0001664_abnormal_digestion0.68166442
94MP0000026_abnormal_inner_ear0.66888391
95MP0005167_abnormal_blood-brain_barrier0.61611643
96MP0003137_abnormal_impulse_conducting0.59399227
97MP0005195_abnormal_posterior_eye0.57938003
98MP0001943_abnormal_respiration0.57621580
99MP0003861_abnormal_nervous_system0.57510549
100MP0000579_abnormal_nail_morphology0.57085214
101MP0001299_abnormal_eye_distance/0.55465559
102MP0004233_abnormal_muscle_weight0.54948359
103MP0001348_abnormal_lacrimal_gland0.54724287
104MP0002638_abnormal_pupillary_reflex0.54687737
105MP0004043_abnormal_pH_regulation0.54165160
106MP0000566_synostosis0.51492505
107MP0003956_abnormal_body_size0.51105149
108MP0010770_preweaning_lethality0.50687690
109MP0002082_postnatal_lethality0.50687690
110MP0006292_abnormal_olfactory_placode0.50449934
111MP0002653_abnormal_ependyma_morphology0.50224547
112MP0010769_abnormal_survival0.49917772
113MP0004130_abnormal_muscle_cell0.49888562
114MP0003938_abnormal_ear_development0.47581006
115MP0000569_abnormal_digit_pigmentation0.47289878
116MP0010768_mortality/aging0.46738596

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.29709335
2Focal seizures (HP:0007359)5.76094559
3Epileptic encephalopathy (HP:0200134)5.53210217
4Myokymia (HP:0002411)5.16405981
5Atonic seizures (HP:0010819)5.01175995
6Hyperventilation (HP:0002883)5.01089865
7Visual hallucinations (HP:0002367)4.66669961
8Febrile seizures (HP:0002373)4.63077952
9Absence seizures (HP:0002121)4.35116660
10Broad-based gait (HP:0002136)4.19075320
11Dialeptic seizures (HP:0011146)4.09430298
12Progressive cerebellar ataxia (HP:0002073)4.06070732
13Generalized tonic-clonic seizures (HP:0002069)3.79845490
14Neurofibrillary tangles (HP:0002185)3.50874156
15Hemiplegia (HP:0002301)3.48825676
16Cerebral inclusion bodies (HP:0100314)3.45729299
17Supranuclear gaze palsy (HP:0000605)3.35371034
18Poor eye contact (HP:0000817)3.27937718
19Gaze-evoked nystagmus (HP:0000640)3.27811257
20Drooling (HP:0002307)3.21565582
21Excessive salivation (HP:0003781)3.21565582
22Amblyopia (HP:0000646)3.20256273
23Dysdiadochokinesis (HP:0002075)3.16937046
24Absent speech (HP:0001344)3.06949931
25Dysmetria (HP:0001310)3.01464938
26Limb dystonia (HP:0002451)2.96702824
27Abnormal social behavior (HP:0012433)2.95423162
28Impaired social interactions (HP:0000735)2.95423162
29Truncal ataxia (HP:0002078)2.95311170
30Action tremor (HP:0002345)2.92508524
31Epileptiform EEG discharges (HP:0011182)2.81249238
32Diplopia (HP:0000651)2.77545052
33Abnormality of binocular vision (HP:0011514)2.77545052
34Progressive inability to walk (HP:0002505)2.75400800
35Tetraplegia (HP:0002445)2.73900180
36Hemiparesis (HP:0001269)2.72143490
37Inability to walk (HP:0002540)2.71301191
38Abnormal eating behavior (HP:0100738)2.68146546
39Anxiety (HP:0000739)2.64974188
40Impaired vibration sensation in the lower limbs (HP:0002166)2.64318953
41Abnormality of the corticospinal tract (HP:0002492)2.61227745
42Mutism (HP:0002300)2.59774850
43Peripheral hypomyelination (HP:0007182)2.56996753
44EEG with generalized epileptiform discharges (HP:0011198)2.55496019
45Protruding tongue (HP:0010808)2.52255126
46Scanning speech (HP:0002168)2.51287771
47Depression (HP:0000716)2.50024385
48Urinary bladder sphincter dysfunction (HP:0002839)2.45460333
49Insidious onset (HP:0003587)2.45251015
50Termporal pattern (HP:0011008)2.45251015
51Fetal akinesia sequence (HP:0001989)2.42881734
52Generalized myoclonic seizures (HP:0002123)2.41863441
53Stereotypic behavior (HP:0000733)2.41173877
54Polyphagia (HP:0002591)2.40518185
55Obstructive sleep apnea (HP:0002870)2.38542835
56Cerebral hypomyelination (HP:0006808)2.37327315
57Postural instability (HP:0002172)2.36223339
58Hypsarrhythmia (HP:0002521)2.34195490
59Ankle clonus (HP:0011448)2.31544336
60Blue irides (HP:0000635)2.31407046
61Clumsiness (HP:0002312)2.29438490
62Gait imbalance (HP:0002141)2.29317053
63Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.27415362
64Degeneration of the lateral corticospinal tracts (HP:0002314)2.27415362
65Genetic anticipation (HP:0003743)2.27102398
66Spastic gait (HP:0002064)2.27028263
67Morphological abnormality of the pyramidal tract (HP:0002062)2.26745624
68Sleep apnea (HP:0010535)2.25220630
69Pheochromocytoma (HP:0002666)2.23530520
70Bradykinesia (HP:0002067)2.22156024
71Impaired smooth pursuit (HP:0007772)2.21782266
72Status epilepticus (HP:0002133)2.20567919
73Abnormality of salivation (HP:0100755)2.18832946
74Intention tremor (HP:0002080)2.17920231
75Retinal dysplasia (HP:0007973)2.16746720
76Widely spaced teeth (HP:0000687)2.11024365
77Akinesia (HP:0002304)2.11001469
78Thickened helices (HP:0000391)2.10770095
79Urinary urgency (HP:0000012)2.10558052
80Papilledema (HP:0001085)2.08636651
81Fair hair (HP:0002286)2.07948348
82Neuronal loss in central nervous system (HP:0002529)2.05043801
83Inappropriate behavior (HP:0000719)2.03539826
84Spastic tetraparesis (HP:0001285)2.03078166
85Amyotrophic lateral sclerosis (HP:0007354)2.02882329
86Megalencephaly (HP:0001355)2.02701756
87Neuroendocrine neoplasm (HP:0100634)2.00800275
88Incomplete penetrance (HP:0003829)1.99619529
89Generalized hypopigmentation of hair (HP:0011358)1.97117671
90Craniofacial dystonia (HP:0012179)1.96189176
91Abnormality of ocular smooth pursuit (HP:0000617)1.94405345
92Prolonged QT interval (HP:0001657)1.93378324
93Gait ataxia (HP:0002066)1.92495227
94Spastic tetraplegia (HP:0002510)1.91436513
95Absent/shortened dynein arms (HP:0200106)1.90940311
96Dynein arm defect of respiratory motile cilia (HP:0012255)1.90940311
97Clonus (HP:0002169)1.90513201
98Lower limb muscle weakness (HP:0007340)1.89642703
99Annular pancreas (HP:0001734)1.89591485
100Exotropia (HP:0000577)1.88664178
101Abnormality of the lower motor neuron (HP:0002366)1.87716575
102Split foot (HP:0001839)1.87704294
103Gastroesophageal reflux (HP:0002020)1.87181681
104Torticollis (HP:0000473)1.85232834
105Aplasia involving bones of the extremities (HP:0009825)1.84781737
106Aplasia involving bones of the upper limbs (HP:0009823)1.84781737
107Aplasia of the phalanges of the hand (HP:0009802)1.84781737
108Increased circulating renin level (HP:0000848)1.84306888
109Type II lissencephaly (HP:0007260)1.82943827
110Delusions (HP:0000746)1.82557754
111Congenital primary aphakia (HP:0007707)1.81839085
112Dysmetric saccades (HP:0000641)1.80698509
113Medial flaring of the eyebrow (HP:0010747)1.79462622
114Esotropia (HP:0000565)1.78167883
115Psychosis (HP:0000709)1.77543869
116CNS hypomyelination (HP:0003429)1.77154651
117Impaired vibratory sensation (HP:0002495)1.77076714
118Syncope (HP:0001279)1.76209780
119Abnormal EKG (HP:0003115)1.75061539
120Focal dystonia (HP:0004373)1.74717519
121Specific learning disability (HP:0001328)1.74006351
122Central scotoma (HP:0000603)1.73863316
123Rigidity (HP:0002063)1.72689365
124Ventricular fibrillation (HP:0001663)1.71182469
125Hypoplasia of the corpus callosum (HP:0002079)1.67896655
126Paraplegia (HP:0010550)1.66941296
127Rapidly progressive (HP:0003678)1.66357244

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.96838658
2NTRK34.27664651
3CASK3.38423165
4MARK13.17915706
5MAP3K43.01653818
6MAP3K92.94096210
7RIPK42.87660047
8MAP2K72.72394603
9PNCK2.40672149
10MINK12.32391262
11TNIK2.22303381
12MAP3K122.16955936
13NTRK21.96326264
14DAPK21.96213382
15MAP2K41.92350560
16PLK21.87529498
17PAK61.71041985
18NTRK11.65962024
19MAPK131.58617338
20SIK21.57602080
21DAPK11.50041243
22KSR11.49031734
23KSR21.47401807
24FES1.44365772
25CDK51.44012495
26BMPR21.41606557
27CDK191.34359498
28GRK51.30089102
29CAMK2A1.26381458
30PRPF4B1.26298816
31OXSR11.22904343
32PRKCG1.21870944
33CAMK2B1.18379591
34TYRO31.17080904
35CAMKK11.12460881
36ARAF0.99786036
37CAMKK20.99047671
38PHKG20.98275373
39PHKG10.98275373
40PTK2B0.95016096
41MAP3K130.93828932
42CCNB10.93504089
43NME10.92439699
44FGR0.91409562
45UHMK10.89721212
46CSNK1G20.88877043
47STK390.87736400
48CDK180.83715739
49PRKD30.82456218
50CDK140.82178964
51CDK150.80958502
52SGK2230.79301757
53SGK4940.79301757
54DYRK20.78111798
55DYRK1A0.76645517
56MAP3K20.74543541
57CAMK40.73880489
58SGK10.73441201
59PAK30.72719659
60PKN10.72045304
61LATS20.71338903
62RAF10.71305407
63PRKCE0.70745516
64CDK11A0.70669004
65CAMK2D0.70093573
66STK380.69441521
67CAMK10.68183114
68STK110.67568083
69CSNK1A1L0.65150194
70SGK20.64640490
71RET0.64499039
72MUSK0.61236519
73CAMK1G0.60392257
74AKT30.56681194
75MARK20.56211088
76MAPK120.55077252
77MAP3K60.54789467
78SIK30.51774710
79CSNK1G10.51218543
80BCR0.50981666
81ROCK20.50162022
82CAMK2G0.49315986
83FYN0.48802858
84PRKCZ0.47730848
85CSNK1D0.46924936
86ALK0.45566404
87PDPK10.45388557
88PDK10.44724484
89WNK10.43673587
90FGFR20.42261767
91WNK30.40149222
92RPS6KA30.39325239
93CSNK1G30.39170485
94NEK60.38859402
95GRK70.38615168
96PRKCH0.37683537
97PRKCA0.36440169
98PRKACA0.36372714
99MAP4K20.36278838
100MAPK100.36259606
101PINK10.36074045
102ROCK10.35803330
103PRKCB0.35418096
104MAPKAPK50.35085108
105SGK30.34916668
106CSNK1E0.34730450
107TNK20.33925004
108RIPK10.33880432
109CSNK1A10.33608298
110MAP2K10.33258199
111ERBB20.33246053
112PRKCQ0.31837849
113WNK40.31803224
114ADRBK10.31440472
115PRKG10.31190868
116FRK0.31042581
117GSK3B0.28304135
118PRKACB0.24892095
119LIMK10.24838721

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.22280718
2Synaptic vesicle cycle_Homo sapiens_hsa047213.00779182
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.94634404
4Long-term potentiation_Homo sapiens_hsa047202.88017467
5Glutamatergic synapse_Homo sapiens_hsa047242.77307855
6GABAergic synapse_Homo sapiens_hsa047272.71457590
7Circadian entrainment_Homo sapiens_hsa047132.67560313
8Amphetamine addiction_Homo sapiens_hsa050312.64189284
9Morphine addiction_Homo sapiens_hsa050322.53308432
10Salivary secretion_Homo sapiens_hsa049702.32067693
11Olfactory transduction_Homo sapiens_hsa047402.27726539
12Dopaminergic synapse_Homo sapiens_hsa047282.27701404
13Serotonergic synapse_Homo sapiens_hsa047262.02013293
14Long-term depression_Homo sapiens_hsa047301.99610203
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.95329877
16Renin secretion_Homo sapiens_hsa049241.91939774
17Taste transduction_Homo sapiens_hsa047421.90916126
18Cholinergic synapse_Homo sapiens_hsa047251.85703738
19Collecting duct acid secretion_Homo sapiens_hsa049661.85153050
20Gastric acid secretion_Homo sapiens_hsa049711.82351832
21Insulin secretion_Homo sapiens_hsa049111.78444750
22Cocaine addiction_Homo sapiens_hsa050301.74519998
23Phototransduction_Homo sapiens_hsa047441.69000166
24Calcium signaling pathway_Homo sapiens_hsa040201.68913229
25Oxytocin signaling pathway_Homo sapiens_hsa049211.65980085
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65382914
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50247893
28Axon guidance_Homo sapiens_hsa043601.37450904
29Gap junction_Homo sapiens_hsa045401.35585384
30GnRH signaling pathway_Homo sapiens_hsa049121.34559771
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30899376
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27489036
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24542129
34cAMP signaling pathway_Homo sapiens_hsa040241.20961035
35Cardiac muscle contraction_Homo sapiens_hsa042601.15843108
36Vibrio cholerae infection_Homo sapiens_hsa051101.13700038
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05276083
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05106558
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05006216
40Estrogen signaling pathway_Homo sapiens_hsa049151.04616000
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03683947
42Alzheimers disease_Homo sapiens_hsa050101.00870996
43Oxidative phosphorylation_Homo sapiens_hsa001900.99043576
44Melanogenesis_Homo sapiens_hsa049160.98501156
45Glioma_Homo sapiens_hsa052140.95550389
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.95382756
47ErbB signaling pathway_Homo sapiens_hsa040120.93731983
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93130258
49Pancreatic secretion_Homo sapiens_hsa049720.91493591
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87929671
51Type II diabetes mellitus_Homo sapiens_hsa049300.87442828
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85184050
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79492246
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78744419
55Choline metabolism in cancer_Homo sapiens_hsa052310.77536689
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74952890
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.74610647
58Dorso-ventral axis formation_Homo sapiens_hsa043200.73536960
59Thyroid hormone synthesis_Homo sapiens_hsa049180.73069158
60Vitamin B6 metabolism_Homo sapiens_hsa007500.72817148
61Oocyte meiosis_Homo sapiens_hsa041140.72769018
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71927973
63African trypanosomiasis_Homo sapiens_hsa051430.69472245
64MAPK signaling pathway_Homo sapiens_hsa040100.65854972
65Dilated cardiomyopathy_Homo sapiens_hsa054140.63303453
66Parkinsons disease_Homo sapiens_hsa050120.62588723
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60122095
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59335724
69Ras signaling pathway_Homo sapiens_hsa040140.58847561
70VEGF signaling pathway_Homo sapiens_hsa043700.58335493
71Glucagon signaling pathway_Homo sapiens_hsa049220.53384354
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.53346490
73Alcoholism_Homo sapiens_hsa050340.50340510
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50094693
75Rap1 signaling pathway_Homo sapiens_hsa040150.48635105
76Wnt signaling pathway_Homo sapiens_hsa043100.43453120
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43330999
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41293120
79Renal cell carcinoma_Homo sapiens_hsa052110.41050161
80Nitrogen metabolism_Homo sapiens_hsa009100.40648211
81Huntingtons disease_Homo sapiens_hsa050160.40384531
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39577323
83Inositol phosphate metabolism_Homo sapiens_hsa005620.39545260
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39304025
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38579604
86Rheumatoid arthritis_Homo sapiens_hsa053230.38074744
87beta-Alanine metabolism_Homo sapiens_hsa004100.35395826
88Circadian rhythm_Homo sapiens_hsa047100.35232564
89Histidine metabolism_Homo sapiens_hsa003400.34848575
90Type I diabetes mellitus_Homo sapiens_hsa049400.34787293
91Ovarian steroidogenesis_Homo sapiens_hsa049130.33294595
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.32926838
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30937601
94Prion diseases_Homo sapiens_hsa050200.30865834
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30274093
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30253831
97Hippo signaling pathway_Homo sapiens_hsa043900.29368924
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28081202
99Bile secretion_Homo sapiens_hsa049760.27303341
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26563058
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26450945
102mTOR signaling pathway_Homo sapiens_hsa041500.24777641
103Ether lipid metabolism_Homo sapiens_hsa005650.24549683
104Mineral absorption_Homo sapiens_hsa049780.24524730
105Fatty acid biosynthesis_Homo sapiens_hsa000610.24472051
106Butanoate metabolism_Homo sapiens_hsa006500.24332163
107Tight junction_Homo sapiens_hsa045300.24199653
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23401885
109AMPK signaling pathway_Homo sapiens_hsa041520.23285556
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22329651
111Endocytosis_Homo sapiens_hsa041440.22161355
112Arginine and proline metabolism_Homo sapiens_hsa003300.22103999
113Non-small cell lung cancer_Homo sapiens_hsa052230.22099392
114Endometrial cancer_Homo sapiens_hsa052130.21908918

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »