CADM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a calcium-independent cell-cell adhesion protein that can form homodimers or heterodimers with other nectin proteins. The encoded protein has both homophilic and heterophilic cell-cell adhesion activity. This gene is reported to be a tumor suppressor gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.22994265
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.21837440
3locomotory exploration behavior (GO:0035641)6.15546956
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.89892938
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.71068088
6vocalization behavior (GO:0071625)5.62638021
7synaptic vesicle exocytosis (GO:0016079)5.29071473
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.16769494
9glutamate secretion (GO:0014047)5.12479095
10regulation of synaptic vesicle exocytosis (GO:2000300)5.02358330
11neuronal action potential propagation (GO:0019227)4.89942338
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.86000671
13layer formation in cerebral cortex (GO:0021819)4.79009286
14cellular potassium ion homeostasis (GO:0030007)4.78946942
15neurotransmitter secretion (GO:0007269)4.73676734
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.73047357
17gamma-aminobutyric acid transport (GO:0015812)4.70340854
18protein localization to synapse (GO:0035418)4.65474858
19exploration behavior (GO:0035640)4.65063617
20regulation of glutamate receptor signaling pathway (GO:1900449)4.62721948
21sodium ion export (GO:0071436)4.60649671
22glutamate receptor signaling pathway (GO:0007215)4.51323720
23response to pheromone (GO:0019236)4.50942053
24L-amino acid import (GO:0043092)4.47572657
25synaptic transmission, glutamatergic (GO:0035249)4.42037068
26cerebellar granule cell differentiation (GO:0021707)4.41979290
27regulation of synaptic vesicle transport (GO:1902803)4.39495401
28cerebellar Purkinje cell differentiation (GO:0021702)4.30928676
29neuron cell-cell adhesion (GO:0007158)4.27951755
30positive regulation of synapse maturation (GO:0090129)4.27568929
31regulation of long-term neuronal synaptic plasticity (GO:0048169)4.22375239
32regulation of neuronal synaptic plasticity (GO:0048168)4.11115216
33regulation of synapse structural plasticity (GO:0051823)4.09361242
34long-term memory (GO:0007616)4.07575065
35amino acid import (GO:0043090)4.07299898
36dendritic spine morphogenesis (GO:0060997)4.06334012
37neuron-neuron synaptic transmission (GO:0007270)4.04506030
38neurotransmitter-gated ion channel clustering (GO:0072578)4.03435485
39G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.02409046
40neuronal ion channel clustering (GO:0045161)4.01207843
41positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.90241896
42axon ensheathment in central nervous system (GO:0032291)3.89457964
43central nervous system myelination (GO:0022010)3.89457964
44cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.87191228
45proline transport (GO:0015824)3.83699878
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.83345794
47neurotransmitter transport (GO:0006836)3.80995548
48positive regulation of membrane potential (GO:0045838)3.80714635
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.78421816
50regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.78087442
51neuromuscular process controlling balance (GO:0050885)3.71237199
52dendrite morphogenesis (GO:0048813)3.66556310
53gamma-aminobutyric acid signaling pathway (GO:0007214)3.63896194
54cell communication by electrical coupling (GO:0010644)3.62740173
55regulation of postsynaptic membrane potential (GO:0060078)3.62627963
56transmission of nerve impulse (GO:0019226)3.59967072
57neuromuscular process controlling posture (GO:0050884)3.59279948
58regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.56150481
59synaptic vesicle endocytosis (GO:0048488)3.52779185
60activation of protein kinase A activity (GO:0034199)3.52687009
61regulation of neurotransmitter levels (GO:0001505)3.51225146
62positive regulation of neurotransmitter transport (GO:0051590)3.50419905
63regulation of neurotransmitter secretion (GO:0046928)3.49834209
64positive regulation of neurotransmitter secretion (GO:0001956)3.49040993
65membrane depolarization during action potential (GO:0086010)3.48455830
66cell differentiation in hindbrain (GO:0021533)3.47618713
67glycine transport (GO:0015816)3.47086681
68presynaptic membrane organization (GO:0097090)3.43822631
69negative regulation of dendrite morphogenesis (GO:0050774)3.39970722
70auditory behavior (GO:0031223)3.39098532
71neuron recognition (GO:0008038)3.35752339
72prepulse inhibition (GO:0060134)3.34750164
73regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.33183628
74membrane hyperpolarization (GO:0060081)3.32226426
75presynaptic membrane assembly (GO:0097105)3.31895100
76dendritic spine organization (GO:0097061)3.31455171
77neuromuscular synaptic transmission (GO:0007274)3.30525224
78regulation of dendritic spine morphogenesis (GO:0061001)3.28628298
79regulation of synaptic plasticity (GO:0048167)3.28543814
80regulation of dendritic spine development (GO:0060998)3.28341662
81regulation of synaptic transmission, glutamatergic (GO:0051966)3.28183233
82postsynaptic membrane organization (GO:0001941)3.27194750
83membrane depolarization (GO:0051899)3.26409114
84potassium ion import (GO:0010107)3.24007722
85regulation of synapse maturation (GO:0090128)3.23879406
86regulation of vesicle fusion (GO:0031338)3.23169772
87synapse assembly (GO:0007416)3.22990702
88cell migration in hindbrain (GO:0021535)3.22416360
89potassium ion homeostasis (GO:0055075)3.21807012
90response to auditory stimulus (GO:0010996)3.21413009
91innervation (GO:0060384)3.21325537
92regulation of neurotransmitter transport (GO:0051588)3.20571313
93negative regulation of synaptic transmission, GABAergic (GO:0032229)3.20474865
94axonal fasciculation (GO:0007413)3.19354008
95regulation of synaptic transmission (GO:0050804)3.18653644
96establishment of mitochondrion localization (GO:0051654)3.17159302
97regulation of ARF protein signal transduction (GO:0032012)3.15524640
98positive regulation of potassium ion transmembrane transport (GO:1901381)3.15364899
99cellular sodium ion homeostasis (GO:0006883)3.14532467
100cytoskeletal anchoring at plasma membrane (GO:0007016)3.14240175
101neurotransmitter uptake (GO:0001504)3.13508601
102G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.13442514
103positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.12641617
104adult walking behavior (GO:0007628)3.12396350
105acidic amino acid transport (GO:0015800)3.11770589
106regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.11043031
107long-term synaptic potentiation (GO:0060291)3.07685206
108neuromuscular process (GO:0050905)3.05371066
109cerebellar Purkinje cell layer development (GO:0021680)3.05056675
110regulation of voltage-gated calcium channel activity (GO:1901385)3.04782863
111synaptic transmission (GO:0007268)3.03808750
112establishment of nucleus localization (GO:0040023)3.03714644
113positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.01042407
114positive regulation of dendritic spine development (GO:0060999)3.00919569
115positive regulation of dendritic spine morphogenesis (GO:0061003)3.00314912
116mating behavior (GO:0007617)2.99912001
117intraspecies interaction between organisms (GO:0051703)2.98232979
118social behavior (GO:0035176)2.98232979
119positive regulation of synaptic transmission, GABAergic (GO:0032230)2.97380926
120learning (GO:0007612)2.94881789
121synapse organization (GO:0050808)2.94184252

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.72463186
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.15798793
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10199101
4GBX2_23144817_ChIP-Seq_PC3_Human3.09368227
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05642037
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.81294584
7DROSHA_22980978_ChIP-Seq_HELA_Human2.81004743
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79834866
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79834866
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64382516
11* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.59011245
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55676741
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54224803
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52871595
15* RARB_27405468_Chip-Seq_BRAIN_Mouse2.47007551
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45910172
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.43003393
18* EZH2_27294783_Chip-Seq_ESCs_Mouse2.38348291
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.37334234
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.31550335
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29623642
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26918386
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.25764130
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.21191920
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.19518711
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07080729
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03258615
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.03118869
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93015960
30AR_21572438_ChIP-Seq_LNCaP_Human1.83995441
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61393921
32* ERG_21242973_ChIP-ChIP_JURKAT_Human1.58561072
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56970220
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.52710604
35ZNF274_21170338_ChIP-Seq_K562_Hela1.49037331
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38412792
37RING1B_27294783_Chip-Seq_ESCs_Mouse1.36229452
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36183570
39* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34745013
40KDM2B_26808549_Chip-Seq_K562_Human1.34616436
41DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33980023
42AR_19668381_ChIP-Seq_PC3_Human1.30729911
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29393783
44SOX2_21211035_ChIP-Seq_LN229_Gbm1.28263910
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24663211
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23504796
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21209126
48WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19403128
49TAF15_26573619_Chip-Seq_HEK293_Human1.18603304
50RING1B_27294783_Chip-Seq_NPCs_Mouse1.18138918
51STAT3_23295773_ChIP-Seq_U87_Human1.17687784
52EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16286821
53AR_25329375_ChIP-Seq_VCAP_Human1.16125734
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15063574
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.14097274
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13686875
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13432365
58GATA1_26923725_Chip-Seq_HPCs_Mouse1.12940895
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.09517571
60P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09257356
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07779138
62P300_19829295_ChIP-Seq_ESCs_Human1.07706577
63EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07249094
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.06533875
65SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04591769
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04317066
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03969169
68YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03942742
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03311445
70* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02942587
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02156744
72TCF4_23295773_ChIP-Seq_U87_Human1.02114979
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00872353
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.00480461
75KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99883762
76PIAS1_25552417_ChIP-Seq_VCAP_Human0.99504053
77TRIM28_21343339_ChIP-Seq_HEK293_Human0.99475839
78SMAD3_21741376_ChIP-Seq_ESCs_Human0.99135006
79SMAD4_21741376_ChIP-Seq_HESCs_Human0.98706763
80BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98606088
81RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98139356
82AHR_22903824_ChIP-Seq_MCF-7_Human0.97947552
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97883414
84* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97193273
85TP53_20018659_ChIP-ChIP_R1E_Mouse0.97147645
86TP53_16413492_ChIP-PET_HCT116_Human0.96182052
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95533568
88IGF1R_20145208_ChIP-Seq_DFB_Human0.94977141
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94788622
90* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94683306
91TET1_21490601_ChIP-Seq_MESCs_Mouse0.94546918
92THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94493493
93RNF2_27304074_Chip-Seq_NSC_Mouse0.91593132
94* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90454777
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90342121
96SMAD3_21741376_ChIP-Seq_HESCs_Human0.90151665
97LXR_22292898_ChIP-Seq_THP-1_Human0.89927670
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89829209
99ESR2_21235772_ChIP-Seq_MCF-7_Human0.89429146
100CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88401945
101SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87993421
102RUNX2_22187159_ChIP-Seq_PCA_Human0.87511603
103DPY_21335234_ChIP-Seq_ESCs_Mouse0.86664125
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86512370
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86071759
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86071759
107NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85677849
108TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85598393
109CTCF_27219007_Chip-Seq_Bcells_Human0.85464668
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84186685
111OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83461726
112OCT4_19829295_ChIP-Seq_ESCs_Human0.83401032
113DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83166715
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82449107
115PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82369655
116* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.81998100
117SMAD4_21741376_ChIP-Seq_EPCs_Human0.81808563
118TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.81634928
119KLF4_19829295_ChIP-Seq_ESCs_Human0.79114757
120SMC4_20622854_ChIP-Seq_HELA_Human0.77070204
121RUNX1_26923725_Chip-Seq_HPCs_Mouse0.76518005
122* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.75488260
123SRY_22984422_ChIP-ChIP_TESTIS_Rat0.75375840
124LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74900439
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.73637722

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.46714305
2MP0003635_abnormal_synaptic_transmissio4.21715895
3MP0003880_abnormal_central_pattern4.03191936
4MP0004270_analgesia3.82043191
5MP0009046_muscle_twitch3.78205572
6MP0005423_abnormal_somatic_nervous3.36143405
7MP0009745_abnormal_behavioral_response3.32649527
8MP0002063_abnormal_learning/memory/cond3.21896516
9MP0002064_seizures3.14340579
10MP0001968_abnormal_touch/_nociception3.13130879
11MP0002734_abnormal_mechanical_nocicepti2.92986266
12MP0002272_abnormal_nervous_system2.76461827
13MP0002572_abnormal_emotion/affect_behav2.73115763
14MP0001486_abnormal_startle_reflex2.56424839
15MP0002735_abnormal_chemical_nociception2.48268153
16MP0008569_lethality_at_weaning2.48166429
17MP0002736_abnormal_nociception_after2.36709607
18MP0001440_abnormal_grooming_behavior2.22776205
19MP0002067_abnormal_sensory_capabilities2.21763968
20MP0002733_abnormal_thermal_nociception2.17788738
21MP0002184_abnormal_innervation2.16853318
22MP0001501_abnormal_sleep_pattern2.15203397
23MP0001970_abnormal_pain_threshold2.05123424
24MP0003329_amyloid_beta_deposits1.99626586
25MP0004858_abnormal_nervous_system1.98333870
26MP0002822_catalepsy1.96219355
27MP0000778_abnormal_nervous_system1.86790553
28MP0004811_abnormal_neuron_physiology1.81469982
29MP0002557_abnormal_social/conspecific_i1.80094927
30MP0004924_abnormal_behavior1.79160397
31MP0005386_behavior/neurological_phenoty1.79160397
32MP0009780_abnormal_chondrocyte_physiolo1.78381430
33MP0000955_abnormal_spinal_cord1.70999547
34MP0004885_abnormal_endolymph1.68358116
35MP0002909_abnormal_adrenal_gland1.64261425
36MP0004145_abnormal_muscle_electrophysio1.63912600
37MP0003879_abnormal_hair_cell1.54159823
38MP0002882_abnormal_neuron_morphology1.53626934
39MP0002066_abnormal_motor_capabilities/c1.50854242
40MP0001984_abnormal_olfaction1.50235199
41MP0006276_abnormal_autonomic_nervous1.49239354
42MP0005551_abnormal_eye_electrophysiolog1.44043041
43MP0003633_abnormal_nervous_system1.42743700
44MP0004142_abnormal_muscle_tone1.42635442
45MP0003123_paternal_imprinting1.35154847
46MP0001502_abnormal_circadian_rhythm1.35032400
47MP0003631_nervous_system_phenotype1.26223778
48MP0000569_abnormal_digit_pigmentation1.25544721
49MP0002229_neurodegeneration1.19006747
50MP0002152_abnormal_brain_morphology1.18750645
51MP0004742_abnormal_vestibular_system1.16507990
52MP0005646_abnormal_pituitary_gland1.14960243
53MP0003632_abnormal_nervous_system1.11131679
54MP0005645_abnormal_hypothalamus_physiol1.08952224
55MP0003787_abnormal_imprinting1.05809256
56MP0008872_abnormal_physiological_respon1.05537673
57MP0000751_myopathy0.95529403
58MP0003634_abnormal_glial_cell0.94417855
59MP0003690_abnormal_glial_cell0.91663897
60MP0002069_abnormal_eating/drinking_beha0.91214051
61MP0000604_amyloidosis0.90154051
62MP0002752_abnormal_somatic_nervous0.89255767
63MP0002090_abnormal_vision0.87848658
64MP0006072_abnormal_retinal_apoptosis0.87822295
65MP0003283_abnormal_digestive_organ0.85871651
66MP0001188_hyperpigmentation0.84776634
67MP0001905_abnormal_dopamine_level0.84499552
68MP0001346_abnormal_lacrimal_gland0.84274070
69MP0005167_abnormal_blood-brain_barrier0.84127352
70MP0001177_atelectasis0.83847597
71MP0005394_taste/olfaction_phenotype0.83501062
72MP0005499_abnormal_olfactory_system0.83501062
73MP0008874_decreased_physiological_sensi0.82308150
74MP0004215_abnormal_myocardial_fiber0.82213693
75MP0003122_maternal_imprinting0.81176411
76MP0004233_abnormal_muscle_weight0.80833604
77MP0002638_abnormal_pupillary_reflex0.80762495
78* MP0000920_abnormal_myelination0.80355943
79MP0004085_abnormal_heartbeat0.79814151
80MP0003137_abnormal_impulse_conducting0.79244197
81MP0004147_increased_porphyrin_level0.78426714
82MP0001963_abnormal_hearing_physiology0.77785627
83MP0001529_abnormal_vocalization0.76434803
84MP0008961_abnormal_basal_metabolism0.75953318
85MP0001299_abnormal_eye_distance/0.73762606
86MP0005535_abnormal_body_temperature0.71855211
87MP0000013_abnormal_adipose_tissue0.71404048
88MP0004130_abnormal_muscle_cell0.70334722
89MP0010386_abnormal_urinary_bladder0.70085686
90MP0005187_abnormal_penis_morphology0.69997876
91MP0005253_abnormal_eye_physiology0.66222560
92MP0000631_abnormal_neuroendocrine_gland0.66045638
93MP0004510_myositis0.64876804
94MP0003121_genomic_imprinting0.64440987
95MP0003075_altered_response_to0.64197853
96MP0002089_abnormal_postnatal_growth/wei0.63602765
97MP0005409_darkened_coat_color0.62900670
98MP0003861_abnormal_nervous_system0.62870361
99MP0004484_altered_response_of0.62008917
100MP0001348_abnormal_lacrimal_gland0.61311030
101MP0000579_abnormal_nail_morphology0.61234820
102MP0010769_abnormal_survival0.60918325
103MP0005623_abnormal_meninges_morphology0.59346265
104MP0004043_abnormal_pH_regulation0.57862414
105MP0000026_abnormal_inner_ear0.57859399
106MP0001485_abnormal_pinna_reflex0.57632482
107MP0003172_abnormal_lysosome_physiology0.57435116
108MP0002082_postnatal_lethality0.57386286
109MP0010770_preweaning_lethality0.57386286
110MP0001986_abnormal_taste_sensitivity0.56876231
111MP0010768_mortality/aging0.56550559
112MP0001943_abnormal_respiration0.56457504
113MP0003938_abnormal_ear_development0.53362829
114MP0002249_abnormal_larynx_morphology0.50236236
115MP0003956_abnormal_body_size0.49477884
116MP0008877_abnormal_DNA_methylation0.48995814

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.54835092
2Myokymia (HP:0002411)6.54051382
3Visual hallucinations (HP:0002367)5.70708906
4Action tremor (HP:0002345)5.58789977
5Focal seizures (HP:0007359)5.57656582
6Progressive cerebellar ataxia (HP:0002073)5.47555459
7Epileptic encephalopathy (HP:0200134)4.55329480
8Febrile seizures (HP:0002373)4.39925285
9Atonic seizures (HP:0010819)4.30171597
10Gaze-evoked nystagmus (HP:0000640)4.02807840
11Absence seizures (HP:0002121)4.01411711
12Supranuclear gaze palsy (HP:0000605)3.79127426
13Broad-based gait (HP:0002136)3.72656289
14Dysdiadochokinesis (HP:0002075)3.64697986
15Generalized tonic-clonic seizures (HP:0002069)3.59876431
16Dialeptic seizures (HP:0011146)3.54634944
17Genetic anticipation (HP:0003743)3.50459115
18Mutism (HP:0002300)3.50084712
19Poor eye contact (HP:0000817)3.47108529
20Ankle clonus (HP:0011448)3.34371350
21Impaired smooth pursuit (HP:0007772)3.31919965
22Dysmetria (HP:0001310)3.30469240
23Truncal ataxia (HP:0002078)3.29000107
24Scanning speech (HP:0002168)3.27974417
25Hemiplegia (HP:0002301)3.25307353
26Depression (HP:0000716)3.23448486
27Abnormality of the lower motor neuron (HP:0002366)3.21067600
28Intention tremor (HP:0002080)3.19614972
29Abnormal social behavior (HP:0012433)3.18367067
30Impaired social interactions (HP:0000735)3.18367067
31Cerebral hypomyelination (HP:0006808)3.16295857
32Hemiparesis (HP:0001269)3.15031942
33Abnormality of binocular vision (HP:0011514)3.07386082
34Diplopia (HP:0000651)3.07386082
35Abnormality of ocular smooth pursuit (HP:0000617)3.04112302
36Dysmetric saccades (HP:0000641)3.03473995
37Urinary bladder sphincter dysfunction (HP:0002839)2.95820305
38Akinesia (HP:0002304)2.95080660
39Impaired vibration sensation in the lower limbs (HP:0002166)2.94860445
40Anxiety (HP:0000739)2.88286430
41Postural instability (HP:0002172)2.87932802
42Abnormal eating behavior (HP:0100738)2.86199406
43Abnormality of the corticospinal tract (HP:0002492)2.80615665
44Papilledema (HP:0001085)2.78455121
45Spastic gait (HP:0002064)2.67048602
46Sleep apnea (HP:0010535)2.66497556
47Amyotrophic lateral sclerosis (HP:0007354)2.61716473
48Drooling (HP:0002307)2.60853936
49Excessive salivation (HP:0003781)2.60853936
50Ventricular fibrillation (HP:0001663)2.60614167
51Status epilepticus (HP:0002133)2.54657460
52Urinary urgency (HP:0000012)2.51638103
53Delusions (HP:0000746)2.51114849
54Peripheral hypomyelination (HP:0007182)2.50107243
55Torticollis (HP:0000473)2.47492402
56Agitation (HP:0000713)2.47330690
57Neurofibrillary tangles (HP:0002185)2.45904632
58Amblyopia (HP:0000646)2.44835066
59Insidious onset (HP:0003587)2.44339488
60Termporal pattern (HP:0011008)2.44339488
61Stereotypic behavior (HP:0000733)2.42444876
62Hyperventilation (HP:0002883)2.40508498
63Annular pancreas (HP:0001734)2.40186574
64Tetraplegia (HP:0002445)2.34918257
65Cerebral inclusion bodies (HP:0100314)2.30190361
66Spastic tetraparesis (HP:0001285)2.28389952
67Focal dystonia (HP:0004373)2.27969216
68Bradykinesia (HP:0002067)2.27261099
69Megalencephaly (HP:0001355)2.26248833
70Diminished motivation (HP:0000745)2.26199484
71Postural tremor (HP:0002174)2.25761897
72Epileptiform EEG discharges (HP:0011182)2.24628700
73Progressive inability to walk (HP:0002505)2.24592272
74EEG with generalized epileptiform discharges (HP:0011198)2.23197746
75Limb dystonia (HP:0002451)2.19926231
76Pointed chin (HP:0000307)2.19198653
77Central scotoma (HP:0000603)2.17472767
78Insomnia (HP:0100785)2.16616517
79Rapidly progressive (HP:0003678)2.15659744
80Fetal akinesia sequence (HP:0001989)2.15208057
81Abnormality of saccadic eye movements (HP:0000570)2.14133171
82Hypsarrhythmia (HP:0002521)2.12426575
83Neuronal loss in central nervous system (HP:0002529)2.11360303
84Pheochromocytoma (HP:0002666)2.11162528
85Absent speech (HP:0001344)2.08915001
86Morphological abnormality of the pyramidal tract (HP:0002062)2.08224338
87Gait ataxia (HP:0002066)2.07862066
88Aplasia involving bones of the upper limbs (HP:0009823)2.07401241
89Aplasia of the phalanges of the hand (HP:0009802)2.07401241
90Aplasia involving bones of the extremities (HP:0009825)2.07401241
91Lower limb muscle weakness (HP:0007340)2.05534810
92Clonus (HP:0002169)2.04873491
93CNS hypomyelination (HP:0003429)2.03945171
94Impaired vibratory sensation (HP:0002495)2.02488749
95Degeneration of the lateral corticospinal tracts (HP:0002314)2.01083590
96Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.01083590
97Horizontal nystagmus (HP:0000666)2.01017023
98Lower limb asymmetry (HP:0100559)2.00677921
99Aqueductal stenosis (HP:0002410)1.99944504
100Craniofacial dystonia (HP:0012179)1.99251727
101Choreoathetosis (HP:0001266)1.97917703
102Inappropriate behavior (HP:0000719)1.93668236
103Obstructive sleep apnea (HP:0002870)1.91624867
104Bundle branch block (HP:0011710)1.91053722
105Incomplete penetrance (HP:0003829)1.90232458
106Turricephaly (HP:0000262)1.89317558
107Generalized myoclonic seizures (HP:0002123)1.89169647
108Spinal canal stenosis (HP:0003416)1.88545871
109Polyphagia (HP:0002591)1.86356938
110Limb ataxia (HP:0002070)1.85682384
111Bronchomalacia (HP:0002780)1.85665409
112Split foot (HP:0001839)1.85270259
113Lower limb amyotrophy (HP:0007210)1.84438813
114Psychosis (HP:0000709)1.84378962
115Abnormality of macular pigmentation (HP:0008002)1.82732327
116Apathy (HP:0000741)1.77542642
117Hammertoe (HP:0001765)1.77237883
118Congenital stationary night blindness (HP:0007642)1.73380855
119Neuroendocrine neoplasm (HP:0100634)1.72755995
120Abnormal EKG (HP:0003115)1.71717091
121Rigidity (HP:0002063)1.71150591

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.18921706
2MARK14.00951336
3MAP3K93.98571896
4MAP3K43.01983268
5MINK12.94659916
6EPHA42.87175427
7PAK62.57545803
8DAPK22.42504097
9NTRK22.34094999
10MAP2K72.31642437
11CAMKK12.25491128
12MAP2K41.95624537
13CAMKK21.94391117
14KSR21.88450314
15NTRK11.78805307
16STK381.74667508
17PRKD31.70879385
18RIPK11.60987969
19CDK51.54955564
20SIK21.53866066
21PHKG11.49317561
22PHKG21.49317561
23MAPK131.44439825
24PRPF4B1.42889715
25KSR11.42625859
26TNIK1.41383934
27PNCK1.36154682
28GRK51.33866215
29MAP3K121.33071816
30RIPK41.33015003
31CDK191.31947574
32PRKCG1.28814286
33TYRO31.22027899
34LATS21.20105151
35DAPK11.19061551
36WNK11.14277730
37CASK1.14215843
38PLK21.14049677
39UHMK11.10316316
40STK111.06035680
41MAP3K21.03963072
42CAMK11.03215088
43TAOK11.01695329
44ALK1.01562257
45RET0.99360173
46PRKCH0.98691608
47SGK2230.98273160
48SGK4940.98273160
49CDK150.98200861
50CDK180.97253063
51FES0.96775447
52LMTK20.92478688
53CDK140.91696949
54CAMK2A0.86481673
55CDK11A0.85824409
56DYRK1A0.84564061
57CAMK1G0.84526458
58PINK10.83331291
59MARK20.82998557
60SGK20.81008205
61SGK30.78704348
62CSNK1G20.72515527
63PAK30.71005322
64SGK10.68482262
65CDC42BPA0.68278164
66MAP3K130.67603825
67ARAF0.65870594
68CAMK2B0.65597771
69OXSR10.63965740
70SCYL20.63030009
71PDK10.62060273
72CAMK40.60662614
73PRKCZ0.57789185
74RPS6KA30.56221907
75FYN0.55233032
76PDPK10.54411241
77DAPK30.53580779
78CAMK2G0.50682517
79LIMK10.49927754
80BRAF0.47875516
81NEK10.46324551
82RAF10.46111869
83CAMK2D0.45530448
84MAPK100.45102972
85ERBB30.44790836
86MAPK120.43849001
87NEK60.43716035
88PKN10.42992523
89MAP3K70.42359047
90ROCK20.41874752
91PTK2B0.41228065
92DYRK20.41088152
93ERBB20.40556111
94RPS6KA20.40505542
95MOS0.39282284
96PRKCE0.39085247
97TNK20.38303752
98PRKG10.37281042
99MAP3K10.36802954
100PRKCB0.36364723
101TESK10.36187115
102MAP3K110.35702087
103BMPR20.35634523
104ROCK10.35282186
105FER0.32939466
106MAPK80.32352414
107CCNB10.31724230
108FGFR20.31040501
109BRSK10.30899091
110ICK0.30457616
111MAP3K60.30260620
112PRKCA0.29297844
113RPS6KB10.26901759
114SRC0.24906648
115MAPK40.23522878

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.86552696
2Synaptic vesicle cycle_Homo sapiens_hsa047213.21792670
3GABAergic synapse_Homo sapiens_hsa047272.75652393
4Glutamatergic synapse_Homo sapiens_hsa047242.74872558
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.71979654
6Circadian entrainment_Homo sapiens_hsa047132.71104020
7Long-term potentiation_Homo sapiens_hsa047202.63789822
8Olfactory transduction_Homo sapiens_hsa047402.46644544
9Morphine addiction_Homo sapiens_hsa050322.45114147
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.35176491
11Salivary secretion_Homo sapiens_hsa049702.23532464
12Amphetamine addiction_Homo sapiens_hsa050312.20345699
13Dopaminergic synapse_Homo sapiens_hsa047282.07444869
14Insulin secretion_Homo sapiens_hsa049111.95251193
15Cholinergic synapse_Homo sapiens_hsa047251.92122669
16Long-term depression_Homo sapiens_hsa047301.90702003
17Gastric acid secretion_Homo sapiens_hsa049711.90110007
18Taste transduction_Homo sapiens_hsa047421.88704916
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.88116130
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.74148413
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.63571258
22Oxytocin signaling pathway_Homo sapiens_hsa049211.63246027
23Renin secretion_Homo sapiens_hsa049241.56336352
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.53563556
25Serotonergic synapse_Homo sapiens_hsa047261.51623799
26Calcium signaling pathway_Homo sapiens_hsa040201.50592811
27Cocaine addiction_Homo sapiens_hsa050301.44049788
28GnRH signaling pathway_Homo sapiens_hsa049121.40884837
29Type II diabetes mellitus_Homo sapiens_hsa049301.39609712
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39163600
31Gap junction_Homo sapiens_hsa045401.33886293
32Vitamin B6 metabolism_Homo sapiens_hsa007501.30899543
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29081608
34cAMP signaling pathway_Homo sapiens_hsa040241.28834015
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24500543
36Phototransduction_Homo sapiens_hsa047441.22943135
37Estrogen signaling pathway_Homo sapiens_hsa049151.20183493
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11151876
39Axon guidance_Homo sapiens_hsa043601.10938111
40Nitrogen metabolism_Homo sapiens_hsa009101.08384834
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05873525
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04872819
43Glioma_Homo sapiens_hsa052141.03913445
44Pancreatic secretion_Homo sapiens_hsa049720.99933540
45Cardiac muscle contraction_Homo sapiens_hsa042600.97375270
46ErbB signaling pathway_Homo sapiens_hsa040120.96176382
47Melanogenesis_Homo sapiens_hsa049160.94460618
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.92181367
49Collecting duct acid secretion_Homo sapiens_hsa049660.90052506
50Thyroid hormone synthesis_Homo sapiens_hsa049180.89150534
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87536755
52Oocyte meiosis_Homo sapiens_hsa041140.86618884
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.85440617
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84948287
55Dorso-ventral axis formation_Homo sapiens_hsa043200.81086463
56Dilated cardiomyopathy_Homo sapiens_hsa054140.77612062
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76817978
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76459946
59Choline metabolism in cancer_Homo sapiens_hsa052310.73686740
60Bile secretion_Homo sapiens_hsa049760.71629660
61MAPK signaling pathway_Homo sapiens_hsa040100.70304759
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.67489707
63mTOR signaling pathway_Homo sapiens_hsa041500.63457163
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62798345
65VEGF signaling pathway_Homo sapiens_hsa043700.61754082
66Inositol phosphate metabolism_Homo sapiens_hsa005620.57414310
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.54170056
68Circadian rhythm_Homo sapiens_hsa047100.54109171
69Endometrial cancer_Homo sapiens_hsa052130.53505720
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52938520
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51871707
72Vibrio cholerae infection_Homo sapiens_hsa051100.50933350
73Glucagon signaling pathway_Homo sapiens_hsa049220.50671448
74Rap1 signaling pathway_Homo sapiens_hsa040150.50095431
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50094977
76Ras signaling pathway_Homo sapiens_hsa040140.49797070
77Endocytosis_Homo sapiens_hsa041440.49432509
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49208138
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48697556
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47539219
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47526678
82Alcoholism_Homo sapiens_hsa050340.45688266
83Renal cell carcinoma_Homo sapiens_hsa052110.44130165
84* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44038915
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42751933
86Fatty acid biosynthesis_Homo sapiens_hsa000610.41314269
87Insulin signaling pathway_Homo sapiens_hsa049100.40083419
88Non-small cell lung cancer_Homo sapiens_hsa052230.39935651
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36670649
90Wnt signaling pathway_Homo sapiens_hsa043100.36195401
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36129424
92Arginine biosynthesis_Homo sapiens_hsa002200.34677858
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34495472
94Chemokine signaling pathway_Homo sapiens_hsa040620.34192910
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34097456
96AMPK signaling pathway_Homo sapiens_hsa041520.34010774
97Ovarian steroidogenesis_Homo sapiens_hsa049130.33294786
98Arginine and proline metabolism_Homo sapiens_hsa003300.32951102
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.32684500
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32018937
101Prion diseases_Homo sapiens_hsa050200.31034946
102Tight junction_Homo sapiens_hsa045300.30971582
103Hippo signaling pathway_Homo sapiens_hsa043900.30495092
104Colorectal cancer_Homo sapiens_hsa052100.29315088
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28853429
106Mineral absorption_Homo sapiens_hsa049780.28642440
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28594386
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27282417
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26558129
110Platelet activation_Homo sapiens_hsa046110.24937597
111Alzheimers disease_Homo sapiens_hsa050100.23578471

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