CADM4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.98931302
2locomotory exploration behavior (GO:0035641)5.76685759
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.41351976
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.13535351
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.11707569
6layer formation in cerebral cortex (GO:0021819)5.03726099
7vocalization behavior (GO:0071625)4.78836163
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.77512718
9glutamate secretion (GO:0014047)4.66532854
10synaptic vesicle exocytosis (GO:0016079)4.63699500
11regulation of synaptic vesicle exocytosis (GO:2000300)4.62591914
12dendritic spine morphogenesis (GO:0060997)4.42805842
13neuronal action potential propagation (GO:0019227)4.41229410
14neuron cell-cell adhesion (GO:0007158)4.33110703
15regulation of glutamate receptor signaling pathway (GO:1900449)4.28405752
16protein localization to synapse (GO:0035418)4.27813444
17gamma-aminobutyric acid transport (GO:0015812)4.23283534
18exploration behavior (GO:0035640)4.22541314
19regulation of synapse structural plasticity (GO:0051823)4.18641949
20synaptic vesicle docking involved in exocytosis (GO:0016081)4.14184784
21regulation of neuronal synaptic plasticity (GO:0048168)4.07383323
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.04090087
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.01427265
24regulation of synaptic vesicle transport (GO:1902803)3.97498824
25neurotransmitter secretion (GO:0007269)3.96225294
26glycine transport (GO:0015816)3.88652588
27potassium ion homeostasis (GO:0055075)3.87705806
28central nervous system myelination (GO:0022010)3.86838187
29axon ensheathment in central nervous system (GO:0032291)3.86838187
30dendrite morphogenesis (GO:0048813)3.78429154
31sodium ion export (GO:0071436)3.68060476
32synaptic transmission, glutamatergic (GO:0035249)3.66790288
33cellular potassium ion homeostasis (GO:0030007)3.66505301
34neuron recognition (GO:0008038)3.64045209
35neuromuscular process controlling balance (GO:0050885)3.59060664
36neurotransmitter-gated ion channel clustering (GO:0072578)3.58170183
37regulation of dendritic spine morphogenesis (GO:0061001)3.54656388
38transmission of nerve impulse (GO:0019226)3.51538935
39neuronal ion channel clustering (GO:0045161)3.49932705
40proline transport (GO:0015824)3.49629489
41glutamate receptor signaling pathway (GO:0007215)3.49531412
42cell migration in hindbrain (GO:0021535)3.47303425
43L-amino acid import (GO:0043092)3.45932821
44positive regulation of membrane potential (GO:0045838)3.45687657
45long-term memory (GO:0007616)3.43388476
46axonal fasciculation (GO:0007413)3.41990124
47neuron-neuron synaptic transmission (GO:0007270)3.39298194
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.37499639
49cellular sodium ion homeostasis (GO:0006883)3.34137359
50auditory behavior (GO:0031223)3.33680303
51negative regulation of synaptic transmission, GABAergic (GO:0032229)3.25765839
52neurotransmitter transport (GO:0006836)3.25715549
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.23548666
54activation of protein kinase A activity (GO:0034199)3.20912572
55postsynaptic membrane organization (GO:0001941)3.18099766
56cerebellar granule cell differentiation (GO:0021707)3.16124961
57regulation of synapse maturation (GO:0090128)3.15362677
58regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.13593132
59regulation of synaptic plasticity (GO:0048167)3.13151688
60positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.13035854
61adult walking behavior (GO:0007628)3.12504748
62pyrimidine nucleobase catabolic process (GO:0006208)3.11870878
63prepulse inhibition (GO:0060134)3.11353060
64response to auditory stimulus (GO:0010996)3.09963660
65mechanosensory behavior (GO:0007638)3.08821420
66dendritic spine organization (GO:0097061)3.05662983
67positive regulation of synapse maturation (GO:0090129)3.05489427
68regulation of postsynaptic membrane potential (GO:0060078)3.05286552
69regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.05046862
70positive regulation of synapse assembly (GO:0051965)3.03935421
71positive regulation of synaptic transmission, GABAergic (GO:0032230)3.02261676
72regulation of neurotransmitter secretion (GO:0046928)3.01909862
73potassium ion import (GO:0010107)2.99979481
74regulation of dendritic spine development (GO:0060998)2.99896581
75presynaptic membrane organization (GO:0097090)2.99616448
76axon ensheathment (GO:0008366)2.99200663
77ensheathment of neurons (GO:0007272)2.99200663
78regulation of neurotransmitter levels (GO:0001505)2.98320650
79cerebellar Purkinje cell layer development (GO:0021680)2.97870853
80positive regulation of dendritic spine development (GO:0060999)2.97104186
81regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.97073471
82regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.96206118
83positive regulation of dendritic spine morphogenesis (GO:0061003)2.96076298
84cell communication by electrical coupling (GO:0010644)2.95856161
85regulation of vesicle fusion (GO:0031338)2.95816043
86cytoskeletal anchoring at plasma membrane (GO:0007016)2.95676581
87cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.94250722
88myelination (GO:0042552)2.92522005
89synaptic vesicle endocytosis (GO:0048488)2.91868838
90presynaptic membrane assembly (GO:0097105)2.90480844
91cerebellar Purkinje cell differentiation (GO:0021702)2.90085459
92negative regulation of axonogenesis (GO:0050771)2.89442928
93establishment of mitochondrion localization (GO:0051654)2.89307131
94membrane hyperpolarization (GO:0060081)2.88848100
95mitochondrion transport along microtubule (GO:0047497)2.87874912
96establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.87874912
97neuromuscular process controlling posture (GO:0050884)2.86809036
98regulation of synaptic transmission, glutamatergic (GO:0051966)2.85541779
99organelle transport along microtubule (GO:0072384)2.85413901
100regulation of neurotransmitter transport (GO:0051588)2.85235877
101positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.84990972
102mating behavior (GO:0007617)2.84346503
103long-term synaptic potentiation (GO:0060291)2.83970375
104vesicle transport along microtubule (GO:0047496)2.83481212
105G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.83130455
106regulation of voltage-gated calcium channel activity (GO:1901385)2.82942076
107neuromuscular process (GO:0050905)2.82144687
108astrocyte development (GO:0014002)2.81976551
109peptidyl-tyrosine autophosphorylation (GO:0038083)2.81615536
110positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.81304789
111astrocyte differentiation (GO:0048708)2.80141157
112amino acid import (GO:0043090)2.80015163
113synapse organization (GO:0050808)2.79989829
114cell differentiation in hindbrain (GO:0021533)2.79582329
115establishment of nucleus localization (GO:0040023)2.79457456
116synapse assembly (GO:0007416)2.78209235
117clathrin coat assembly (GO:0048268)2.78063721
118regulation of respiratory system process (GO:0044065)2.76661236
119regulation of ARF protein signal transduction (GO:0032012)2.75674871
120positive regulation of dendrite development (GO:1900006)2.75106366
121membrane assembly (GO:0071709)2.74447342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.08692046
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04678040
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.00315917
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.99799894
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.82649999
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.82649999
7GBX2_23144817_ChIP-Seq_PC3_Human2.65341799
8DROSHA_22980978_ChIP-Seq_HELA_Human2.65207260
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61062115
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.59188802
11* RARB_27405468_Chip-Seq_BRAIN_Mouse2.55344427
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.54769152
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.54296815
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48433369
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47576221
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47299326
17REST_21632747_ChIP-Seq_MESCs_Mouse2.47081420
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.42265518
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.38939873
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.33532457
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.27021493
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.24772663
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.21911854
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.15770178
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.08132853
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.01111196
27RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.98090946
28AR_21572438_ChIP-Seq_LNCaP_Human1.96613632
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88465876
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85637925
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82062117
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.80481232
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57153563
34KDM2B_26808549_Chip-Seq_K562_Human1.49773372
35RING1B_27294783_Chip-Seq_ESCs_Mouse1.48295997
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.47922286
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.46569923
38ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44701274
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40776121
40* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36444036
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34904733
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34031620
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32966052
44RING1B_27294783_Chip-Seq_NPCs_Mouse1.32817991
45RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29517325
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28983965
47LXR_22292898_ChIP-Seq_THP-1_Human1.28631588
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27278502
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25684906
50EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22572858
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20632740
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20162013
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18575175
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.17031746
55SMAD4_21799915_ChIP-Seq_A2780_Human1.16258998
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15770227
57TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12900308
58AR_19668381_ChIP-Seq_PC3_Human1.12881700
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12758435
60RNF2_27304074_Chip-Seq_NSC_Mouse1.11865196
61ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11614496
62GATA1_26923725_Chip-Seq_HPCs_Mouse1.11519027
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10790753
64ZNF274_21170338_ChIP-Seq_K562_Hela1.10706956
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09566666
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07282165
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.06798829
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05040461
69EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04918525
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.04422815
71* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04320627
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03458731
73OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02311576
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01848001
75STAT3_23295773_ChIP-Seq_U87_Human1.00144186
76AHR_22903824_ChIP-Seq_MCF-7_Human0.99081448
77TET1_21490601_ChIP-Seq_MESCs_Mouse0.98820807
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98473231
79ARNT_22903824_ChIP-Seq_MCF-7_Human0.98252254
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97915455
81CTCF_27219007_Chip-Seq_Bcells_Human0.97573026
82KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96417863
83POU5F1_16518401_ChIP-PET_MESCs_Mouse0.96357746
84YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95329878
85SMAD4_21741376_ChIP-Seq_HESCs_Human0.95312048
86ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94652900
87SMC4_20622854_ChIP-Seq_HELA_Human0.93993531
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93174928
89SMAD3_21741376_ChIP-Seq_ESCs_Human0.92770903
90ESR2_21235772_ChIP-Seq_MCF-7_Human0.91471726
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88837497
92TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87853203
93* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87780633
94ISL1_27105846_Chip-Seq_CPCs_Mouse0.87246299
95KDM2B_26808549_Chip-Seq_DND41_Human0.87189121
96TP53_20018659_ChIP-ChIP_R1E_Mouse0.86815582
97* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86734947
98* RUNX1_26923725_Chip-Seq_HPCs_Mouse0.86543924
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86496913
100SMAD3_21741376_ChIP-Seq_HESCs_Human0.86444494
101AR_25329375_ChIP-Seq_VCAP_Human0.85643480
102TAF15_26573619_Chip-Seq_HEK293_Human0.84836739
103ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84661296
104* TP53_23651856_ChIP-Seq_MEFs_Mouse0.84438892
105ESR1_20079471_ChIP-ChIP_T-47D_Human0.84230983
106KDM2B_26808549_Chip-Seq_JURKAT_Human0.83784514
107CREB1_26743006_Chip-Seq_LNCaP_Human0.83352889
108TCF4_23295773_ChIP-Seq_U87_Human0.83186923
109TRIM28_21343339_ChIP-Seq_HEK293_Human0.82818851
110SRY_22984422_ChIP-ChIP_TESTIS_Rat0.82273533
111P300_19829295_ChIP-Seq_ESCs_Human0.82158551
112SOX3_22085726_ChIP-Seq_NPCs_Mouse0.82137352
113PIAS1_25552417_ChIP-Seq_VCAP_Human0.82002758
114CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81881757
115SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.81726878
116NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81633335
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81422200
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80703447
119OCT4_19829295_ChIP-Seq_ESCs_Human0.79440442
120EP300_21415370_ChIP-Seq_HL-1_Mouse0.79260641
121DPY_21335234_ChIP-Seq_ESCs_Mouse0.79008966
122SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.78316397
123PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78045071
124* KLF4_19829295_ChIP-Seq_ESCs_Human0.77991349
125* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.74114795
126MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.73986165
127ESR1_15608294_ChIP-ChIP_MCF-7_Human0.73279324
128PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.71879204
129STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.70816956

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.27416134
2MP0003880_abnormal_central_pattern4.20877330
3MP0004270_analgesia4.00551748
4MP0003635_abnormal_synaptic_transmissio3.90168301
5MP0005423_abnormal_somatic_nervous3.12978125
6MP0009745_abnormal_behavioral_response3.08362615
7MP0002063_abnormal_learning/memory/cond3.05201669
8MP0002064_seizures3.04855673
9MP0009046_muscle_twitch2.85466915
10MP0002734_abnormal_mechanical_nocicepti2.71423858
11MP0001486_abnormal_startle_reflex2.68421305
12MP0001968_abnormal_touch/_nociception2.61786034
13MP0002272_abnormal_nervous_system2.61506003
14MP0004885_abnormal_endolymph2.51523519
15MP0002572_abnormal_emotion/affect_behav2.46142106
16MP0003329_amyloid_beta_deposits2.42523097
17MP0000778_abnormal_nervous_system2.36223760
18MP0000920_abnormal_myelination2.35818062
19MP0002822_catalepsy2.20961952
20MP0008569_lethality_at_weaning2.12983535
21MP0004858_abnormal_nervous_system2.12648905
22MP0002733_abnormal_thermal_nociception2.07230477
23MP0009780_abnormal_chondrocyte_physiolo2.00431828
24MP0001440_abnormal_grooming_behavior1.94169108
25MP0001970_abnormal_pain_threshold1.91384217
26MP0000955_abnormal_spinal_cord1.90189428
27MP0002067_abnormal_sensory_capabilities1.87420637
28MP0004811_abnormal_neuron_physiology1.84781706
29MP0002736_abnormal_nociception_after1.75611801
30MP0002184_abnormal_innervation1.75144595
31MP0003690_abnormal_glial_cell1.69192864
32MP0002735_abnormal_chemical_nociception1.69019848
33MP0001501_abnormal_sleep_pattern1.68240816
34MP0003634_abnormal_glial_cell1.68142012
35MP0002557_abnormal_social/conspecific_i1.63569132
36MP0002882_abnormal_neuron_morphology1.60108539
37MP0000566_synostosis1.57642532
38MP0005386_behavior/neurological_phenoty1.57347111
39MP0004924_abnormal_behavior1.57347111
40MP0004142_abnormal_muscle_tone1.56348060
41MP0002066_abnormal_motor_capabilities/c1.52978989
42MP0003633_abnormal_nervous_system1.48714215
43MP0003123_paternal_imprinting1.48152720
44MP0003631_nervous_system_phenotype1.39592390
45MP0002909_abnormal_adrenal_gland1.38310338
46MP0003632_abnormal_nervous_system1.35615779
47MP0004742_abnormal_vestibular_system1.33384867
48MP0005623_abnormal_meninges_morphology1.31596330
49MP0000579_abnormal_nail_morphology1.28707596
50MP0003879_abnormal_hair_cell1.26776991
51MP0002152_abnormal_brain_morphology1.25877277
52MP0002229_neurodegeneration1.22112243
53MP0000751_myopathy1.18366934
54MP0001905_abnormal_dopamine_level1.14979325
55MP0009379_abnormal_foot_pigmentation1.13610679
56MP0000604_amyloidosis1.12642272
57MP0005646_abnormal_pituitary_gland1.12101115
58MP0003283_abnormal_digestive_organ1.11835838
59MP0002249_abnormal_larynx_morphology1.10172307
60MP0001529_abnormal_vocalization1.10157542
61MP0001502_abnormal_circadian_rhythm1.08525267
62MP0001485_abnormal_pinna_reflex1.07807022
63MP0001984_abnormal_olfaction1.03281142
64MP0006276_abnormal_autonomic_nervous1.00528935
65MP0001177_atelectasis0.98757861
66MP0005645_abnormal_hypothalamus_physiol0.98161243
67MP0002638_abnormal_pupillary_reflex0.97707473
68MP0004145_abnormal_muscle_electrophysio0.95711562
69MP0001299_abnormal_eye_distance/0.95699965
70MP0001963_abnormal_hearing_physiology0.93704773
71MP0001188_hyperpigmentation0.91029824
72MP0002752_abnormal_somatic_nervous0.90530411
73MP0003938_abnormal_ear_development0.88386546
74MP0003787_abnormal_imprinting0.88337300
75MP0005167_abnormal_blood-brain_barrier0.88303097
76MP0000747_muscle_weakness0.87544822
77MP0000013_abnormal_adipose_tissue0.86940957
78MP0003075_altered_response_to0.86490261
79MP0002069_abnormal_eating/drinking_beha0.85414781
80MP0003121_genomic_imprinting0.84706581
81MP0001346_abnormal_lacrimal_gland0.84629169
82MP0000537_abnormal_urethra_morphology0.84491637
83MP0005551_abnormal_eye_electrophysiolog0.83376378
84MP0005171_absent_coat_pigmentation0.83041740
85MP0003137_abnormal_impulse_conducting0.79872560
86MP0002653_abnormal_ependyma_morphology0.79506506
87MP0003861_abnormal_nervous_system0.78237215
88MP0001348_abnormal_lacrimal_gland0.76393952
89MP0002090_abnormal_vision0.76042273
90MP0004043_abnormal_pH_regulation0.75389753
91MP0004085_abnormal_heartbeat0.74392841
92MP0004233_abnormal_muscle_weight0.74288950
93MP0000631_abnormal_neuroendocrine_gland0.74151963
94MP0008961_abnormal_basal_metabolism0.74075549
95MP0003119_abnormal_digestive_system0.72246237
96MP0008874_decreased_physiological_sensi0.72033563
97MP0005409_darkened_coat_color0.71049316
98MP0004133_heterotaxia0.68872737
99MP0002081_perinatal_lethality0.66323610
100MP0000569_abnormal_digit_pigmentation0.64664558
101MP0001943_abnormal_respiration0.64090664
102MP0005499_abnormal_olfactory_system0.63080694
103MP0005394_taste/olfaction_phenotype0.63080694
104MP0008872_abnormal_physiological_respon0.62498903
105MP0000762_abnormal_tongue_morphology0.62275227
106MP0000462_abnormal_digestive_system0.61954303
107MP0000049_abnormal_middle_ear0.61482074
108MP0003136_yellow_coat_color0.61224348
109MP0010769_abnormal_survival0.58656734
110MP0005187_abnormal_penis_morphology0.58450617
111MP0003122_maternal_imprinting0.58369961
112MP0000534_abnormal_ureter_morphology0.58361156
113MP0000026_abnormal_inner_ear0.55606716
114MP0010770_preweaning_lethality0.55285447
115MP0002082_postnatal_lethality0.55285447
116MP0002089_abnormal_postnatal_growth/wei0.54378340
117MP0010768_mortality/aging0.53836440

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.26231335
2Action tremor (HP:0002345)5.22997734
3Focal motor seizures (HP:0011153)4.95490816
4Termporal pattern (HP:0011008)4.56640814
5Insidious onset (HP:0003587)4.56640814
6Supranuclear gaze palsy (HP:0000605)4.31558667
7Ankle clonus (HP:0011448)4.22826752
8Focal seizures (HP:0007359)4.22740797
9Visual hallucinations (HP:0002367)4.14001508
10Neurofibrillary tangles (HP:0002185)3.91827410
11Peripheral hypomyelination (HP:0007182)3.55029062
12Abnormality of the corticospinal tract (HP:0002492)3.49434196
13Progressive cerebellar ataxia (HP:0002073)3.46268485
14Epileptic encephalopathy (HP:0200134)3.44574224
15Cerebral inclusion bodies (HP:0100314)3.39378958
16Megalencephaly (HP:0001355)3.30219917
17Ulnar claw (HP:0001178)3.23452349
18Intention tremor (HP:0002080)3.20767415
19Spastic gait (HP:0002064)3.19420064
20Mutism (HP:0002300)3.18814265
21Atonic seizures (HP:0010819)3.13721251
22Dysmetria (HP:0001310)3.11225642
23Urinary urgency (HP:0000012)3.06264126
24Onion bulb formation (HP:0003383)3.00905275
25Urinary bladder sphincter dysfunction (HP:0002839)2.99825469
26Turricephaly (HP:0000262)2.95333825
27Postural instability (HP:0002172)2.86341191
28Degeneration of the lateral corticospinal tracts (HP:0002314)2.82474348
29Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.82474348
30Impaired vibration sensation in the lower limbs (HP:0002166)2.81282667
31Depression (HP:0000716)2.81084435
32Broad-based gait (HP:0002136)2.79408186
33Dysdiadochokinesis (HP:0002075)2.76764679
34Sleep apnea (HP:0010535)2.74710214
35Absence seizures (HP:0002121)2.72618041
36Generalized tonic-clonic seizures (HP:0002069)2.70042030
37Poor eye contact (HP:0000817)2.69964377
38Segmental peripheral demyelination/remyelination (HP:0003481)2.66974989
39Torticollis (HP:0000473)2.66648195
40Papilledema (HP:0001085)2.66381762
41Abnormal eating behavior (HP:0100738)2.62965593
42Split foot (HP:0001839)2.61722147
43Hyperacusis (HP:0010780)2.60775792
44Hemiparesis (HP:0001269)2.59449603
45Insomnia (HP:0100785)2.54035404
46Scanning speech (HP:0002168)2.53629926
47Anxiety (HP:0000739)2.53544051
48Impaired social interactions (HP:0000735)2.53394832
49Abnormal social behavior (HP:0012433)2.53394832
50Bronchomalacia (HP:0002780)2.52837017
51Dialeptic seizures (HP:0011146)2.52260735
52Akinesia (HP:0002304)2.51654601
53Limb dystonia (HP:0002451)2.50249488
54Hammertoe (HP:0001765)2.49912471
55Lower limb muscle weakness (HP:0007340)2.46869500
56Genetic anticipation (HP:0003743)2.44974536
57Gaze-evoked nystagmus (HP:0000640)2.44635033
58Febrile seizures (HP:0002373)2.43741023
59Truncal ataxia (HP:0002078)2.40840623
60Abnormality of the lower motor neuron (HP:0002366)2.40542130
61Postural tremor (HP:0002174)2.40193547
62Focal dystonia (HP:0004373)2.36852782
63Clonus (HP:0002169)2.34684989
64Abnormality of binocular vision (HP:0011514)2.34556617
65Diplopia (HP:0000651)2.34556617
66Pheochromocytoma (HP:0002666)2.33172691
67Excessive salivation (HP:0003781)2.30560154
68Drooling (HP:0002307)2.30560154
69Hemiplegia (HP:0002301)2.27448469
70Elfin facies (HP:0004428)2.24955413
71Progressive inability to walk (HP:0002505)2.22121427
72Shallow orbits (HP:0000586)2.18977183
73Craniofacial dystonia (HP:0012179)2.15680965
74Amyotrophic lateral sclerosis (HP:0007354)2.14574251
75Abnormality of the diencephalon (HP:0010662)2.14350172
76Polyphagia (HP:0002591)2.13125861
77Alacrima (HP:0000522)2.13010982
78Ventricular fibrillation (HP:0001663)2.12288414
79Obstructive sleep apnea (HP:0002870)2.11973306
80Partial duplication of thumb phalanx (HP:0009944)2.10591165
81Decreased motor nerve conduction velocity (HP:0003431)2.08197319
82Aplasia involving bones of the extremities (HP:0009825)2.07783429
83Aplasia involving bones of the upper limbs (HP:0009823)2.07783429
84Aplasia of the phalanges of the hand (HP:0009802)2.07783429
85Fetal akinesia sequence (HP:0001989)2.05685209
86Stereotypic behavior (HP:0000733)2.04430626
87Morphological abnormality of the inner ear (HP:0011390)2.03595253
88Amblyopia (HP:0000646)2.03197147
89Foot dorsiflexor weakness (HP:0009027)2.03066741
90Annular pancreas (HP:0001734)2.00601052
91Spastic tetraparesis (HP:0001285)1.99585392
92Morphological abnormality of the pyramidal tract (HP:0002062)1.98816218
93Bradykinesia (HP:0002067)1.98228381
94Pointed chin (HP:0000307)1.96473715
95Neuronal loss in central nervous system (HP:0002529)1.94855416
96Renovascular hypertension (HP:0100817)1.92548748
97Rapidly progressive (HP:0003678)1.91999727
98Overriding aorta (HP:0002623)1.91646338
99Epileptiform EEG discharges (HP:0011182)1.91645556
100Steppage gait (HP:0003376)1.91416166
101Lower limb asymmetry (HP:0100559)1.91067037
102Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.90004523
103Abnormality of the foot musculature (HP:0001436)1.89742478
104Status epilepticus (HP:0002133)1.88557840
105Bundle branch block (HP:0011710)1.87964291
106Neuroendocrine neoplasm (HP:0100634)1.85998418
107Distal sensory impairment (HP:0002936)1.85915399
108Partial duplication of the phalanx of hand (HP:0009999)1.85415545
109Apathy (HP:0000741)1.85092391
110Tetraplegia (HP:0002445)1.83786467
111Renal duplication (HP:0000075)1.82668160
112Hyperventilation (HP:0002883)1.82606917
113Gait ataxia (HP:0002066)1.82159973
114Cerebral hypomyelination (HP:0006808)1.81427200
115Hypsarrhythmia (HP:0002521)1.80816900
116Abnormality of saccadic eye movements (HP:0000570)1.80338098
117Abnormal auditory evoked potentials (HP:0006958)1.80291722
118Impaired smooth pursuit (HP:0007772)1.80109408
119EEG with generalized epileptiform discharges (HP:0011198)1.80016762
120Rigidity (HP:0002063)1.79963093
121Diminished motivation (HP:0000745)1.78840358
122Cutaneous finger syndactyly (HP:0010554)1.76865124
123Anomalous pulmonary venous return (HP:0010772)1.73275764
124Arnold-Chiari malformation (HP:0002308)1.69780973
125Coronal craniosynostosis (HP:0004440)1.69507315
126Thickened helices (HP:0000391)1.69455898
127Septo-optic dysplasia (HP:0100842)1.68945839
128Cutaneous syndactyly (HP:0012725)1.66576827

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.27701874
2MAP3K93.58409358
3EPHA43.34321381
4NTRK33.06772229
5PAK62.73269725
6MINK12.36646099
7PRKD32.30086436
8NTRK22.19552241
9MAP3K42.18163418
10DAPK22.15114279
11NTRK12.13919316
12KSR22.09772815
13TYRO31.99353175
14CAMKK11.82400754
15STK391.81490396
16UHMK11.80201839
17PHKG11.68846763
18PHKG21.68846763
19CDK51.61852510
20OXSR11.58106061
21CDK191.46359419
22MAP2K71.42948872
23TNIK1.38759374
24KSR11.36418810
25MAPK151.31677047
26MAPK131.25525648
27ICK1.24914889
28PKN11.22061042
29LIMK11.20999070
30MAP3K21.20840682
31PRPF4B1.20089431
32MAP2K41.19505298
33TRIB31.14097944
34LATS21.11882735
35CDK151.11168307
36SIK21.10778758
37CSNK1G21.10017967
38CDK141.09765574
39TAOK11.09328177
40PNCK1.09176271
41ALK1.08046416
42CDK181.07303398
43STK381.07051963
44RET1.05901294
45LMTK21.04410833
46MARK21.03007619
47WNK11.01603108
48SGK2231.01301427
49SGK4941.01301427
50STK111.00804180
51PAK30.99715043
52CDK11A0.98471679
53PRKCG0.95277780
54EPHB20.94910616
55PLK20.94112118
56FGFR20.93796675
57PRKCH0.93543511
58WNK40.91029896
59GRK50.89140953
60SGK20.88519774
61FES0.87151474
62CAMK2B0.86455937
63CASK0.80959257
64ROCK20.80816092
65CAMK2A0.80324922
66SGK30.77340757
67PINK10.76456612
68CSNK1G30.75718656
69NEK60.74727856
70DDR20.73972690
71CSNK1A1L0.73708785
72ARAF0.72174013
73DAPK10.72134890
74CAMKK20.71955769
75CAMK1G0.67542477
76ERBB20.67001497
77FYN0.66035398
78PDPK10.65573310
79CAMK10.63701870
80PRKCZ0.62871076
81RIPK10.62834920
82DYRK20.61315472
83FGR0.60339803
84DYRK1A0.59859156
85RIPK40.59347805
86MAP3K130.59018351
87MAPK120.58054040
88CAMK2D0.57977413
89BRSK10.57679754
90CAMK2G0.55663232
91SGK10.54788866
92PDK10.54749758
93EPHB10.53889018
94BCR0.52743853
95EPHA30.51170483
96DAPK30.50467578
97SCYL20.49536219
98BMX0.49498660
99MAPKAPK50.48870977
100RPS6KA30.47323137
101CDC42BPA0.47111373
102PRKD10.46719286
103PRKCE0.46659956
104RPS6KA20.46245588
105DYRK1B0.45407986
106DMPK0.45243835
107PDGFRA0.45010427
108ROCK10.44758127
109CSNK1G10.44588467
110MAPK100.43042644
111CAMK40.42277781
112PTK20.41562318
113RAF10.41312625
114BRAF0.40065121
115CAMK1D0.38090147
116MOS0.37259521
117PDGFRB0.34779496
118EEF2K0.32971172
119TESK10.31355642
120CSNK1E0.29267487
121PAK20.28377009
122FGFR40.27991101

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.89994821
2Nicotine addiction_Homo sapiens_hsa050332.83824576
3GABAergic synapse_Homo sapiens_hsa047272.57719008
4Glutamatergic synapse_Homo sapiens_hsa047242.46547615
5Circadian entrainment_Homo sapiens_hsa047132.39757197
6Olfactory transduction_Homo sapiens_hsa047402.38857546
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.24785234
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22658689
9Morphine addiction_Homo sapiens_hsa050322.20944670
10Long-term potentiation_Homo sapiens_hsa047202.18278894
11Nitrogen metabolism_Homo sapiens_hsa009102.12417365
12Dopaminergic synapse_Homo sapiens_hsa047281.96853803
13Salivary secretion_Homo sapiens_hsa049701.93688832
14Amphetamine addiction_Homo sapiens_hsa050311.93201919
15Gastric acid secretion_Homo sapiens_hsa049711.88357644
16Cholinergic synapse_Homo sapiens_hsa047251.83276433
17Axon guidance_Homo sapiens_hsa043601.78634497
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.72103696
19Insulin secretion_Homo sapiens_hsa049111.66067235
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65708483
21Long-term depression_Homo sapiens_hsa047301.63570814
22Cocaine addiction_Homo sapiens_hsa050301.58900119
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.56430015
24Gap junction_Homo sapiens_hsa045401.47742584
25Oxytocin signaling pathway_Homo sapiens_hsa049211.46216707
26Renin secretion_Homo sapiens_hsa049241.43066861
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41264878
28Serotonergic synapse_Homo sapiens_hsa047261.40421285
29GnRH signaling pathway_Homo sapiens_hsa049121.33306368
30Taste transduction_Homo sapiens_hsa047421.30793110
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22975290
32Glioma_Homo sapiens_hsa052141.20840576
33Calcium signaling pathway_Homo sapiens_hsa040201.19602232
34ErbB signaling pathway_Homo sapiens_hsa040121.18436887
35Vitamin B6 metabolism_Homo sapiens_hsa007501.17666473
36Estrogen signaling pathway_Homo sapiens_hsa049151.16244909
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16221135
38cAMP signaling pathway_Homo sapiens_hsa040241.15690366
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11644600
40Dorso-ventral axis formation_Homo sapiens_hsa043201.09000064
41Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.08492825
42Type II diabetes mellitus_Homo sapiens_hsa049301.08472708
43Phospholipase D signaling pathway_Homo sapiens_hsa040721.05233958
44Melanogenesis_Homo sapiens_hsa049161.02075735
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97546133
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97069666
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94223029
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93926490
49Notch signaling pathway_Homo sapiens_hsa043300.92527834
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91527314
51cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87359283
52Renal cell carcinoma_Homo sapiens_hsa052110.86730554
53Collecting duct acid secretion_Homo sapiens_hsa049660.85478855
54Dilated cardiomyopathy_Homo sapiens_hsa054140.85291446
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.84749494
56Cardiac muscle contraction_Homo sapiens_hsa042600.82510618
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79552666
58Sphingolipid signaling pathway_Homo sapiens_hsa040710.78239838
59Endocytosis_Homo sapiens_hsa041440.77756729
60Pancreatic secretion_Homo sapiens_hsa049720.77138651
61Choline metabolism in cancer_Homo sapiens_hsa052310.76683891
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75488625
63Basal cell carcinoma_Homo sapiens_hsa052170.75310110
64Oocyte meiosis_Homo sapiens_hsa041140.72998778
65Ras signaling pathway_Homo sapiens_hsa040140.71628946
66Thyroid hormone synthesis_Homo sapiens_hsa049180.71161890
67VEGF signaling pathway_Homo sapiens_hsa043700.70964964
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69671846
69Endometrial cancer_Homo sapiens_hsa052130.69377084
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.69322732
71MAPK signaling pathway_Homo sapiens_hsa040100.69307455
72Bile secretion_Homo sapiens_hsa049760.68628761
73Vibrio cholerae infection_Homo sapiens_hsa051100.68220301
74Tight junction_Homo sapiens_hsa045300.66277407
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64923440
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64272026
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63771655
78Rap1 signaling pathway_Homo sapiens_hsa040150.63342821
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62484271
80Inositol phosphate metabolism_Homo sapiens_hsa005620.62143118
81Prion diseases_Homo sapiens_hsa050200.61245249
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60559663
83Alcoholism_Homo sapiens_hsa050340.56377710
84Butanoate metabolism_Homo sapiens_hsa006500.56145145
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55083064
86Phototransduction_Homo sapiens_hsa047440.54503317
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54123724
88mTOR signaling pathway_Homo sapiens_hsa041500.52998134
89Arginine and proline metabolism_Homo sapiens_hsa003300.51508092
90Non-small cell lung cancer_Homo sapiens_hsa052230.51081185
91ECM-receptor interaction_Homo sapiens_hsa045120.49829189
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49770002
93Fatty acid biosynthesis_Homo sapiens_hsa000610.49378709
94Wnt signaling pathway_Homo sapiens_hsa043100.48928419
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45880658
96Hedgehog signaling pathway_Homo sapiens_hsa043400.45094945
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42271643
98AMPK signaling pathway_Homo sapiens_hsa041520.42015815
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41857997
100Histidine metabolism_Homo sapiens_hsa003400.41651811
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41480105
102Ovarian steroidogenesis_Homo sapiens_hsa049130.41095583
103Adherens junction_Homo sapiens_hsa045200.41094155
104Glucagon signaling pathway_Homo sapiens_hsa049220.41065577
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40449517
106Chemokine signaling pathway_Homo sapiens_hsa040620.40274713
107Ether lipid metabolism_Homo sapiens_hsa005650.40089047
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40020233
109Focal adhesion_Homo sapiens_hsa045100.38843290
110Protein digestion and absorption_Homo sapiens_hsa049740.38331026
111Colorectal cancer_Homo sapiens_hsa052100.37510359
112Hippo signaling pathway_Homo sapiens_hsa043900.37430297
113Insulin signaling pathway_Homo sapiens_hsa049100.37208658
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37073274

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