CADPS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.85347630
2synaptic vesicle exocytosis (GO:0016079)5.54529675
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.46837142
4glutamate secretion (GO:0014047)5.35078156
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.14541213
6neuron cell-cell adhesion (GO:0007158)5.12054081
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.90440217
8locomotory exploration behavior (GO:0035641)4.89043940
9ionotropic glutamate receptor signaling pathway (GO:0035235)4.81620361
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.72218591
11neuronal action potential propagation (GO:0019227)4.67529972
12positive regulation of synapse maturation (GO:0090129)4.60108003
13glutamate receptor signaling pathway (GO:0007215)4.56895819
14neurotransmitter secretion (GO:0007269)4.55722871
15cellular sodium ion homeostasis (GO:0006883)4.55064525
16regulation of synaptic vesicle exocytosis (GO:2000300)4.52838634
17synaptic vesicle maturation (GO:0016188)4.49732324
18protein localization to synapse (GO:0035418)4.43882396
19cerebellar granule cell differentiation (GO:0021707)4.36646498
20gamma-aminobutyric acid transport (GO:0015812)4.26288327
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.21254102
22synaptic transmission, glutamatergic (GO:0035249)4.21013956
23regulation of glutamate receptor signaling pathway (GO:1900449)4.18374067
24neuron-neuron synaptic transmission (GO:0007270)4.16044702
25L-amino acid import (GO:0043092)4.14587674
26synaptic vesicle docking involved in exocytosis (GO:0016081)4.14054079
27cellular potassium ion homeostasis (GO:0030007)4.10297506
28cell communication by electrical coupling (GO:0010644)4.09162410
29regulation of synaptic vesicle transport (GO:1902803)4.07522254
30mating behavior (GO:0007617)4.07480388
31gamma-aminobutyric acid signaling pathway (GO:0007214)4.06511334
32cerebellar Purkinje cell differentiation (GO:0021702)3.96014275
33exploration behavior (GO:0035640)3.93579771
34G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.91802403
35potassium ion import (GO:0010107)3.89592022
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.88521484
37long-term memory (GO:0007616)3.87558071
38potassium ion homeostasis (GO:0055075)3.86704260
39neurotransmitter transport (GO:0006836)3.83070502
40positive regulation of dendritic spine morphogenesis (GO:0061003)3.81407816
41regulation of neuronal synaptic plasticity (GO:0048168)3.80807704
42neurotransmitter-gated ion channel clustering (GO:0072578)3.79192561
43regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.77983903
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.75990185
45regulation of postsynaptic membrane potential (GO:0060078)3.74116288
46negative regulation of synaptic transmission, GABAergic (GO:0032229)3.72940339
47synaptic vesicle endocytosis (GO:0048488)3.72190584
48axon ensheathment in central nervous system (GO:0032291)3.70484130
49central nervous system myelination (GO:0022010)3.70484130
50behavioral response to cocaine (GO:0048148)3.70401658
51amino acid import (GO:0043090)3.68314912
52regulation of neurotransmitter levels (GO:0001505)3.68238226
53layer formation in cerebral cortex (GO:0021819)3.67777753
54neuron recognition (GO:0008038)3.67515121
55regulation of synapse maturation (GO:0090128)3.57510207
56positive regulation of membrane potential (GO:0045838)3.49825827
57long-term synaptic potentiation (GO:0060291)3.49395671
58positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.45531313
59cell communication involved in cardiac conduction (GO:0086065)3.43643294
60positive regulation of dendritic spine development (GO:0060999)3.42761802
61regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.41135984
62axonal fasciculation (GO:0007413)3.39468967
63sodium ion export (GO:0071436)3.36757021
64cytoskeletal anchoring at plasma membrane (GO:0007016)3.33745070
65transmission of nerve impulse (GO:0019226)3.33260504
66neuronal ion channel clustering (GO:0045161)3.33065704
67regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.32321244
68proline transport (GO:0015824)3.32117548
69response to histamine (GO:0034776)3.30971878
70regulation of vesicle fusion (GO:0031338)3.29491564
71regulation of synaptic plasticity (GO:0048167)3.27704269
72cell differentiation in hindbrain (GO:0021533)3.25451160
73membrane depolarization (GO:0051899)3.23713159
74dopamine biosynthetic process (GO:0042416)3.23511807
75synapse assembly (GO:0007416)3.21641342
76dendritic spine morphogenesis (GO:0060997)3.20677931
77regulation of neurotransmitter secretion (GO:0046928)3.16857265
78regulation of synaptic transmission, glutamatergic (GO:0051966)3.14238808
79regulation of synapse structural plasticity (GO:0051823)3.13632338
80innervation (GO:0060384)3.12013562
81social behavior (GO:0035176)3.11539368
82intraspecies interaction between organisms (GO:0051703)3.11539368
83negative regulation of dendrite morphogenesis (GO:0050774)3.11012309
84prepulse inhibition (GO:0060134)3.10209879
85cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.09734943
86presynaptic membrane assembly (GO:0097105)3.08264840
87membrane depolarization during action potential (GO:0086010)3.08171599
88presynaptic membrane organization (GO:0097090)3.05527184
89auditory behavior (GO:0031223)3.04951988
90regulation of ARF protein signal transduction (GO:0032012)3.04854058
91neuromuscular process controlling posture (GO:0050884)3.03486156
92positive regulation of synapse assembly (GO:0051965)3.02570292
93response to pheromone (GO:0019236)3.02427854
94activation of protein kinase A activity (GO:0034199)3.00556880
95regulation of dendritic spine morphogenesis (GO:0061001)2.99122403
96sodium ion homeostasis (GO:0055078)2.98913149
97membrane hyperpolarization (GO:0060081)2.97605830
98positive regulation of neurotransmitter secretion (GO:0001956)2.97137379
99synaptic vesicle transport (GO:0048489)2.96881564
100establishment of synaptic vesicle localization (GO:0097480)2.96881564
101negative regulation of neurotransmitter transport (GO:0051589)2.96842909
102detection of calcium ion (GO:0005513)2.93647688
103regulation of neurotransmitter transport (GO:0051588)2.93378083
104synaptic transmission (GO:0007268)2.93316710
105long term synaptic depression (GO:0060292)2.92898809
106dopamine transport (GO:0015872)2.92713160
107response to insecticide (GO:0017085)2.90389308
108neuromuscular process controlling balance (GO:0050885)2.89888950
109negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.89753380
110regulation of dendritic spine development (GO:0060998)2.89711736
111learning (GO:0007612)2.88960326
112postsynaptic membrane organization (GO:0001941)2.88009423
113neurotransmitter uptake (GO:0001504)2.86073860
114fear response (GO:0042596)2.85742326
115behavioral fear response (GO:0001662)2.85343856
116behavioral defense response (GO:0002209)2.85343856
117regulation of voltage-gated calcium channel activity (GO:1901385)2.85095237
118mechanosensory behavior (GO:0007638)2.83858473
119regulation of glutamate secretion (GO:0014048)2.83822010
120cochlea development (GO:0090102)2.75709873
121positive regulation of dendrite development (GO:1900006)2.69172086
122cerebellar Purkinje cell layer development (GO:0021680)2.67476341
123serotonin metabolic process (GO:0042428)2.62727931
124positive regulation of neurotransmitter transport (GO:0051590)2.62232259
125C4-dicarboxylate transport (GO:0015740)2.56634553
126regulation of sodium ion transmembrane transporter activity (GO:2000649)2.56342615
127neuromuscular process (GO:0050905)2.56174705
128acidic amino acid transport (GO:0015800)2.55022928
129signal release (GO:0023061)2.54412143

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.17310825
2* GBX2_23144817_ChIP-Seq_PC3_Human3.49299765
3* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06913504
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99199426
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86860286
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59393511
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59393511
8* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56056141
9REST_21632747_ChIP-Seq_MESCs_Mouse2.49758372
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45002344
11* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41125707
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40708703
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40251784
14TAF15_26573619_Chip-Seq_HEK293_Human2.35491694
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34370676
16DROSHA_22980978_ChIP-Seq_HELA_Human2.28353216
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.25391390
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.19696176
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.08247718
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.04048868
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03750774
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96009480
23REST_18959480_ChIP-ChIP_MESCs_Mouse1.95834811
24* RNF2_27304074_Chip-Seq_ESCs_Mouse1.95273250
25RARB_27405468_Chip-Seq_BRAIN_Mouse1.92487443
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84842212
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82858353
28SMAD4_21799915_ChIP-Seq_A2780_Human1.82158385
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75136152
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73358915
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70872924
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68860746
33ZNF274_21170338_ChIP-Seq_K562_Hela1.64957596
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62961022
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.61113408
36P300_19829295_ChIP-Seq_ESCs_Human1.61011335
37AR_21572438_ChIP-Seq_LNCaP_Human1.59128630
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.53713130
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51972720
40* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.50106233
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.49698729
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48381816
43RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.45797981
44EP300_21415370_ChIP-Seq_HL-1_Mouse1.44277928
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42846995
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.42096179
47* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41296835
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.40941709
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37449348
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.37379898
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36184364
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35852692
53* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.35136314
54AR_25329375_ChIP-Seq_VCAP_Human1.34471818
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33397180
56* SOX2_21211035_ChIP-Seq_LN229_Gbm1.33022193
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31730446
58* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31133891
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30829372
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.30828358
61* STAT3_23295773_ChIP-Seq_U87_Human1.29877939
62* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29748617
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27298489
64* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25984588
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25397593
66TP53_16413492_ChIP-PET_HCT116_Human1.24451046
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23604115
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.23404400
69BCAT_22108803_ChIP-Seq_LS180_Human1.22871850
70AHR_22903824_ChIP-Seq_MCF-7_Human1.22659285
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21989916
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.21257631
73* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20367841
74* TCF4_23295773_ChIP-Seq_U87_Human1.16574901
75* AR_19668381_ChIP-Seq_PC3_Human1.16024394
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15086882
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13511668
78ESR1_21235772_ChIP-Seq_MCF-7_Human1.13384459
79RUNX2_22187159_ChIP-Seq_PCA_Human1.12417407
80* RING1B_27294783_Chip-Seq_ESCs_Mouse1.12174667
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11845439
82FUS_26573619_Chip-Seq_HEK293_Human1.11471246
83IGF1R_20145208_ChIP-Seq_DFB_Human1.10213915
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09114458
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08829147
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08674130
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08422322
88RNF2_27304074_Chip-Seq_NSC_Mouse1.07803864
89FOXA2_19822575_ChIP-Seq_HepG2_Human1.06988815
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06670842
91TP53_18474530_ChIP-ChIP_U2OS_Human1.06609642
92SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04395228
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04216680
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04216680
95ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03548843
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03526350
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02941441
98KDM2B_26808549_Chip-Seq_K562_Human1.02771015
99GATA1_26923725_Chip-Seq_HPCs_Mouse1.02134031
100RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02073924
101* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00979135
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00822823
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.00532402
104PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00039985
105ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99191197
106* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99138754
107ISL1_27105846_Chip-Seq_CPCs_Mouse0.98844640
108PRDM14_20953172_ChIP-Seq_ESCs_Human0.98128820
109LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98091253
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97499981
111YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96797726
112SMAD3_21741376_ChIP-Seq_HESCs_Human0.96651493
113ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96505545
114ESR1_20079471_ChIP-ChIP_T-47D_Human0.95661486
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95590683
116ER_23166858_ChIP-Seq_MCF-7_Human0.95571981
117NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95272588
118SOX9_26525672_Chip-Seq_HEART_Mouse0.94606662
119TET1_21490601_ChIP-Seq_MESCs_Mouse0.93390329
120RING1B_27294783_Chip-Seq_NPCs_Mouse0.93017000
121SMAD3_21741376_ChIP-Seq_ESCs_Human0.92667608
122KDM2B_26808549_Chip-Seq_REH_Human0.91494748
123TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91247683
124RXR_22108803_ChIP-Seq_LS180_Human0.91055293
125SMAD4_21741376_ChIP-Seq_EPCs_Human0.90538170
126P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89727565
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89083646
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89062069
129SMAD4_21741376_ChIP-Seq_HESCs_Human0.88872129

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.77974130
2MP0003880_abnormal_central_pattern4.80133676
3* MP0003635_abnormal_synaptic_transmissio4.07137995
4MP0009046_muscle_twitch3.53908634
5MP0009745_abnormal_behavioral_response3.34049787
6MP0004270_analgesia3.30896235
7MP0002064_seizures3.14225806
8* MP0002063_abnormal_learning/memory/cond3.13911200
9MP0001968_abnormal_touch/_nociception2.90586874
10* MP0002572_abnormal_emotion/affect_behav2.74535669
11MP0002272_abnormal_nervous_system2.70843986
12MP0002736_abnormal_nociception_after2.48765821
13MP0001486_abnormal_startle_reflex2.47532400
14MP0002734_abnormal_mechanical_nocicepti2.44339836
15MP0005423_abnormal_somatic_nervous2.38838029
16MP0001440_abnormal_grooming_behavior2.38741194
17MP0002735_abnormal_chemical_nociception2.26608847
18* MP0001501_abnormal_sleep_pattern2.20803898
19* MP0002067_abnormal_sensory_capabilities2.19724183
20MP0003123_paternal_imprinting2.13853442
21MP0002184_abnormal_innervation2.11594771
22MP0008569_lethality_at_weaning2.11070734
23MP0001984_abnormal_olfaction2.01099607
24MP0002822_catalepsy2.00788579
25MP0006276_abnormal_autonomic_nervous1.96678118
26MP0003329_amyloid_beta_deposits1.90871954
27MP0005386_behavior/neurological_phenoty1.86020232
28MP0004924_abnormal_behavior1.86020232
29* MP0002557_abnormal_social/conspecific_i1.85499805
30MP0003879_abnormal_hair_cell1.84672883
31MP0002733_abnormal_thermal_nociception1.79347798
32MP0009780_abnormal_chondrocyte_physiolo1.76748320
33MP0001970_abnormal_pain_threshold1.69689342
34MP0001905_abnormal_dopamine_level1.68344634
35MP0000566_synostosis1.65888912
36MP0002909_abnormal_adrenal_gland1.65208961
37MP0000778_abnormal_nervous_system1.65089766
38MP0001188_hyperpigmentation1.63107498
39MP0005645_abnormal_hypothalamus_physiol1.51215232
40MP0005646_abnormal_pituitary_gland1.47964564
41* MP0004811_abnormal_neuron_physiology1.47930192
42MP0004858_abnormal_nervous_system1.44183629
43* MP0002066_abnormal_motor_capabilities/c1.40515868
44MP0002837_dystrophic_cardiac_calcinosis1.40144232
45MP0004145_abnormal_muscle_electrophysio1.40046188
46MP0004885_abnormal_endolymph1.39719029
47MP0001529_abnormal_vocalization1.36689254
48MP0000955_abnormal_spinal_cord1.34937654
49MP0008872_abnormal_physiological_respon1.33709242
50* MP0002882_abnormal_neuron_morphology1.29209008
51MP0003633_abnormal_nervous_system1.25116730
52MP0004142_abnormal_muscle_tone1.22696851
53MP0002139_abnormal_hepatobiliary_system1.19334039
54MP0003631_nervous_system_phenotype1.18379047
55MP0003787_abnormal_imprinting1.17178323
56MP0002876_abnormal_thyroid_physiology1.16394496
57* MP0001502_abnormal_circadian_rhythm1.14952228
58MP0005499_abnormal_olfactory_system1.13407541
59MP0005394_taste/olfaction_phenotype1.13407541
60MP0005187_abnormal_penis_morphology1.11640388
61MP0003632_abnormal_nervous_system1.08592137
62MP0010234_abnormal_vibrissa_follicle1.04887200
63* MP0002152_abnormal_brain_morphology1.04738731
64MP0001485_abnormal_pinna_reflex1.03620337
65MP0010386_abnormal_urinary_bladder1.03617894
66MP0001346_abnormal_lacrimal_gland1.02017936
67MP0002229_neurodegeneration1.01966340
68MP0005535_abnormal_body_temperature1.01183563
69MP0001963_abnormal_hearing_physiology1.00325346
70* MP0004742_abnormal_vestibular_system0.97612428
71MP0002069_abnormal_eating/drinking_beha0.97024505
72MP0005551_abnormal_eye_electrophysiolog0.95004521
73MP0000604_amyloidosis0.94735431
74MP0001299_abnormal_eye_distance/0.94517337
75MP0000579_abnormal_nail_morphology0.93572295
76MP0008874_decreased_physiological_sensi0.93444475
77MP0005409_darkened_coat_color0.91534656
78MP0003121_genomic_imprinting0.89566508
79MP0003122_maternal_imprinting0.88584882
80MP0000631_abnormal_neuroendocrine_gland0.86710279
81MP0001664_abnormal_digestion0.86118632
82MP0005167_abnormal_blood-brain_barrier0.82227484
83MP0000013_abnormal_adipose_tissue0.80058748
84MP0001177_atelectasis0.79740866
85MP0005623_abnormal_meninges_morphology0.79150231
86MP0004484_altered_response_of0.78440390
87MP0003890_abnormal_embryonic-extraembry0.77345945
88MP0008877_abnormal_DNA_methylation0.76534405
89MP0002752_abnormal_somatic_nervous0.74437874
90MP0010368_abnormal_lymphatic_system0.74437275
91MP0003690_abnormal_glial_cell0.73909924
92MP0004085_abnormal_heartbeat0.73420243
93MP0004215_abnormal_myocardial_fiber0.72824871
94MP0000569_abnormal_digit_pigmentation0.66381804
95MP0010678_abnormal_skin_adnexa0.66148552
96MP0002160_abnormal_reproductive_system0.66135627
97* MP0003861_abnormal_nervous_system0.65380473
98MP0000537_abnormal_urethra_morphology0.64114341
99MP0000026_abnormal_inner_ear0.63322720
100MP0008789_abnormal_olfactory_epithelium0.63226154
101MP0001348_abnormal_lacrimal_gland0.62821978
102MP0003941_abnormal_skin_development0.62093924
103MP0002089_abnormal_postnatal_growth/wei0.61514036
104MP0004043_abnormal_pH_regulation0.61296811
105MP0002638_abnormal_pupillary_reflex0.61009058
106MP0008875_abnormal_xenobiotic_pharmacok0.60287014
107MP0000751_myopathy0.60043556
108MP0004147_increased_porphyrin_level0.59936966
109MP0000462_abnormal_digestive_system0.57157065
110MP0002249_abnormal_larynx_morphology0.56797431
111MP0003634_abnormal_glial_cell0.56556734
112MP0003283_abnormal_digestive_organ0.56421143
113MP0000534_abnormal_ureter_morphology0.55544085
114MP0000920_abnormal_myelination0.55328405
115MP0001943_abnormal_respiration0.54667450
116MP0010768_mortality/aging0.53900736
117MP0002090_abnormal_vision0.53585111
118MP0005083_abnormal_biliary_tract0.52614837
119MP0001765_abnormal_ion_homeostasis0.51816191
120MP0003868_abnormal_feces_composition0.51444123
121MP0003045_fibrosis0.51440594
122MP0010770_preweaning_lethality0.51415817
123MP0002082_postnatal_lethality0.51415817
124MP0010769_abnormal_survival0.51135855
125MP0000639_abnormal_adrenal_gland0.49359316
126* MP0003956_abnormal_body_size0.49035156

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.57066948
2Visual hallucinations (HP:0002367)6.17980919
3Focal seizures (HP:0007359)5.85453072
4Progressive cerebellar ataxia (HP:0002073)5.47366642
5Atonic seizures (HP:0010819)5.41093213
6Myokymia (HP:0002411)5.16214180
7Febrile seizures (HP:0002373)4.94549037
8Action tremor (HP:0002345)4.81127898
9Epileptic encephalopathy (HP:0200134)4.71475768
10Absence seizures (HP:0002121)4.69697222
11Hyperventilation (HP:0002883)4.37504796
12Dialeptic seizures (HP:0011146)4.17470436
13Gaze-evoked nystagmus (HP:0000640)4.12760599
14Generalized tonic-clonic seizures (HP:0002069)4.00691231
15Limb dystonia (HP:0002451)3.81265734
16Broad-based gait (HP:0002136)3.77242470
17Truncal ataxia (HP:0002078)3.60855641
18Scanning speech (HP:0002168)3.49650514
19Impaired smooth pursuit (HP:0007772)3.41508815
20Cerebral inclusion bodies (HP:0100314)3.39340755
21Dysdiadochokinesis (HP:0002075)3.37659499
22Poor eye contact (HP:0000817)3.22286899
23Dysmetria (HP:0001310)3.13847761
24Abnormality of ocular smooth pursuit (HP:0000617)3.12315559
25Impaired social interactions (HP:0000735)3.03494857
26Abnormal social behavior (HP:0012433)3.03494857
27Status epilepticus (HP:0002133)3.02777835
28Anxiety (HP:0000739)3.00305704
29Supranuclear gaze palsy (HP:0000605)2.97035756
30Obstructive sleep apnea (HP:0002870)2.93403055
31Depression (HP:0000716)2.91368773
32Dysmetric saccades (HP:0000641)2.87083915
33Drooling (HP:0002307)2.83446575
34Excessive salivation (HP:0003781)2.83446575
35Bronchomalacia (HP:0002780)2.82286104
36Pheochromocytoma (HP:0002666)2.81337676
37Intention tremor (HP:0002080)2.80885217
38Genetic anticipation (HP:0003743)2.78273632
39Neurofibrillary tangles (HP:0002185)2.75757511
40Amblyopia (HP:0000646)2.73133048
41Hemiparesis (HP:0001269)2.61825624
42Postural instability (HP:0002172)2.61804971
43Diplopia (HP:0000651)2.59272961
44Abnormality of binocular vision (HP:0011514)2.59272961
45Annular pancreas (HP:0001734)2.58507585
46Impaired vibration sensation in the lower limbs (HP:0002166)2.54594091
47Agitation (HP:0000713)2.52348399
48Hemiplegia (HP:0002301)2.51742441
49Aplasia involving bones of the upper limbs (HP:0009823)2.48966871
50Aplasia of the phalanges of the hand (HP:0009802)2.48966871
51Aplasia involving bones of the extremities (HP:0009825)2.48966871
52Abnormality of the lower motor neuron (HP:0002366)2.48390668
53Bradykinesia (HP:0002067)2.47694054
54Epileptiform EEG discharges (HP:0011182)2.46819423
55Absent speech (HP:0001344)2.44961878
56Postural tremor (HP:0002174)2.42847884
57Cerebral hypomyelination (HP:0006808)2.42477102
58Progressive inability to walk (HP:0002505)2.37776038
59Abnormal eating behavior (HP:0100738)2.36790604
60Neuroendocrine neoplasm (HP:0100634)2.36687642
61Protruding tongue (HP:0010808)2.32939430
62EEG with generalized epileptiform discharges (HP:0011198)2.30975617
63Lower limb muscle weakness (HP:0007340)2.29503309
64Degeneration of the lateral corticospinal tracts (HP:0002314)2.28163116
65Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.28163116
66Abnormality of the corticospinal tract (HP:0002492)2.27897690
67Gait ataxia (HP:0002066)2.23205767
68Akinesia (HP:0002304)2.22738485
69Sleep apnea (HP:0010535)2.21914840
70Urinary bladder sphincter dysfunction (HP:0002839)2.20625776
71Termporal pattern (HP:0011008)2.16186915
72Insidious onset (HP:0003587)2.16186915
73Generalized myoclonic seizures (HP:0002123)2.15725878
74Psychosis (HP:0000709)2.14436072
75Bundle branch block (HP:0011710)2.14407156
76Stereotypic behavior (HP:0000733)2.11153183
77Horizontal nystagmus (HP:0000666)2.10933093
78Hypsarrhythmia (HP:0002521)2.10871888
79Spastic gait (HP:0002064)2.09644203
80Mutism (HP:0002300)2.07735910
81Fetal akinesia sequence (HP:0001989)2.07723772
82Ankle clonus (HP:0011448)2.07321226
83Blue irides (HP:0000635)2.05644429
84Ventricular fibrillation (HP:0001663)2.04468289
85Hyperaldosteronism (HP:0000859)2.03956407
86Morphological abnormality of the pyramidal tract (HP:0002062)2.02223701
87Limb ataxia (HP:0002070)2.01830039
88Inability to walk (HP:0002540)2.01424096
89Hepatoblastoma (HP:0002884)2.00686165
90Increased circulating renin level (HP:0000848)1.97165926
91Tetraplegia (HP:0002445)1.96374409
92Impaired vibratory sensation (HP:0002495)1.93762925
93Rigidity (HP:0002063)1.92795119
94Alacrima (HP:0000522)1.91586675
95Delusions (HP:0000746)1.91549132
96Clonus (HP:0002169)1.90399814
97Abnormality of salivation (HP:0100755)1.89340410
98Dyskinesia (HP:0100660)1.89283327
99Focal dystonia (HP:0004373)1.88318396
100Incomplete penetrance (HP:0003829)1.87741436
101Shallow orbits (HP:0000586)1.87502415
102Craniofacial dystonia (HP:0012179)1.85811188
103Abnormality of saccadic eye movements (HP:0000570)1.85801325
104Renal salt wasting (HP:0000127)1.85166699
105Failure to thrive in infancy (HP:0001531)1.84674204
106CNS hypomyelination (HP:0003429)1.82586322
107Amyotrophic lateral sclerosis (HP:0007354)1.81974732
108Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.81928043
109Insomnia (HP:0100785)1.81670979
110Torticollis (HP:0000473)1.81506911
111Overgrowth (HP:0001548)1.78912131
112Generalized hypopigmentation of hair (HP:0011358)1.78410623
113Fair hair (HP:0002286)1.77088525
114Choreoathetosis (HP:0001266)1.75045646
115Urinary urgency (HP:0000012)1.74703826
116Retinal dysplasia (HP:0007973)1.73250400
117Gastroesophageal reflux (HP:0002020)1.72480352
118Papilledema (HP:0001085)1.72099758
119Cerebral hemorrhage (HP:0001342)1.70789635
120Lower limb asymmetry (HP:0100559)1.70126868
121Gait imbalance (HP:0002141)1.69447312
122Hypoventilation (HP:0002791)1.68800399
123Neuronal loss in central nervous system (HP:0002529)1.68632265
124Rapidly progressive (HP:0003678)1.68254789
125Thickened helices (HP:0000391)1.68029425
126Genital tract atresia (HP:0001827)1.67338221
127Spastic tetraparesis (HP:0001285)1.66803352
128Hyperactive renin-angiotensin system (HP:0000841)1.66762120
129Spinal cord compression (HP:0002176)1.65730687
130Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.65041554
131Turricephaly (HP:0000262)1.64921399
132Papillary thyroid carcinoma (HP:0002895)1.63599406
133Megalencephaly (HP:0001355)1.61924303
134Heart block (HP:0012722)1.60652969

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.99265791
2MAP3K43.52332996
3EPHA43.37268203
4MAP2K73.13968174
5MAP3K93.06792245
6MAP3K122.94314539
7MAP2K42.78091905
8DAPK22.58252286
9MINK12.57658469
10CASK2.46346551
11RIPK42.35926068
12PNCK2.10748375
13MARK12.02002851
14GRK51.98659145
15PLK21.93356753
16NTRK21.87951599
17CAMKK21.75533994
18PAK61.69647161
19KSR21.66735487
20CDK191.57111313
21NTRK11.52273453
22CAMKK11.52018524
23AKT31.48268808
24DAPK11.46709904
25KSR11.41914887
26CDK51.33789561
27BMPR21.33376071
28OXSR11.31703018
29MAPKAPK51.30138097
30STK381.28766936
31EEF2K1.28110777
32ARAF1.27784024
33CAMK2A1.23896722
34PRKCG1.22081200
35CAMK2B1.19866056
36SIK21.15699341
37PTK2B1.13245742
38PRPF4B1.12887349
39MAP3K21.11457588
40TNIK1.08628447
41SGK21.06895109
42MAPK131.06496991
43SGK2231.04526194
44SGK4941.04526194
45NEK61.03989199
46MAP3K131.02023142
47CSNK1G21.00165448
48STK38L0.98922779
49STK390.96127809
50NME10.95507547
51RET0.95220316
52FGR0.94454758
53RIPK10.93539475
54CAMK10.88944000
55UHMK10.86381631
56WNK10.86110977
57CAMK2D0.85707624
58DYRK1A0.84492768
59CAMK2G0.82383256
60FRK0.81753111
61MET0.81063330
62CDK180.78760929
63SGK30.77031690
64BRSK10.77003593
65CDK150.76077987
66STK110.74025015
67MARK20.73954389
68TYRO30.72954412
69PDGFRA0.72580636
70CDK140.72555467
71CAMK1G0.72063263
72GRK60.71377980
73PRKD30.71312184
74FES0.70796668
75PHKG20.68451539
76PHKG10.68451539
77ALK0.68450971
78MAP3K60.67950361
79SGK10.67932851
80TIE10.67194025
81LMTK20.66996795
82LATS20.66639765
83TSSK60.65839981
84CDK11A0.65109151
85PINK10.63564164
86MAPK100.63355101
87MST1R0.62613697
88RAF10.60561145
89FER0.60066885
90PRKCH0.58396290
91PTK20.57946373
92PAK30.57051630
93CSNK1G30.54757445
94PDK10.52434874
95LATS10.51363108
96PRKCE0.50414616
97MAP3K10.49615438
98CAMK40.48711815
99FGFR10.48621769
100ERBB20.48139429
101CSNK1E0.47833463
102BCR0.47118797
103PIK3CA0.47079442
104DMPK0.46562030
105PKN10.46483502
106PRKCZ0.45845233
107ROCK10.44894502
108WNK40.44799140
109ROCK20.44778276
110FGFR20.44513704
111SIK30.43805331
112FGFR30.42782556
113STK240.42680744
114PDPK10.41287427
115RPS6KA30.40529529
116FYN0.40423475
117TNK20.40292833
118MAP2K10.39715898
119DAPK30.37936262
120CAMK1D0.37727025
121SCYL20.37506041
122ERBB30.37327800
123BRAF0.35852103
124PRKACA0.35425554
125PRKG10.34850560

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.18107731
2Synaptic vesicle cycle_Homo sapiens_hsa047213.22846924
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.85392261
4Long-term potentiation_Homo sapiens_hsa047202.79283146
5Glutamatergic synapse_Homo sapiens_hsa047242.70027654
6Amphetamine addiction_Homo sapiens_hsa050312.66235475
7GABAergic synapse_Homo sapiens_hsa047272.61574184
8Circadian entrainment_Homo sapiens_hsa047132.59659480
9Morphine addiction_Homo sapiens_hsa050322.30385648
10Olfactory transduction_Homo sapiens_hsa047402.28627050
11Salivary secretion_Homo sapiens_hsa049702.25976344
12Taste transduction_Homo sapiens_hsa047422.23082406
13Dopaminergic synapse_Homo sapiens_hsa047282.20579728
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.08391622
15Long-term depression_Homo sapiens_hsa047302.02328832
16Insulin secretion_Homo sapiens_hsa049111.93864142
17Vitamin B6 metabolism_Homo sapiens_hsa007501.84786566
18Serotonergic synapse_Homo sapiens_hsa047261.83758579
19Gastric acid secretion_Homo sapiens_hsa049711.79963470
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72529756
21Cholinergic synapse_Homo sapiens_hsa047251.70065845
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.68036135
23Cocaine addiction_Homo sapiens_hsa050301.66184312
24Collecting duct acid secretion_Homo sapiens_hsa049661.64560734
25Renin secretion_Homo sapiens_hsa049241.62560045
26Calcium signaling pathway_Homo sapiens_hsa040201.52982252
27Oxytocin signaling pathway_Homo sapiens_hsa049211.40790597
28GnRH signaling pathway_Homo sapiens_hsa049121.40203398
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39159630
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35561171
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30276190
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21865411
33Histidine metabolism_Homo sapiens_hsa003401.21569068
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18670304
35cAMP signaling pathway_Homo sapiens_hsa040241.12731491
36Gap junction_Homo sapiens_hsa045401.11991734
37Type II diabetes mellitus_Homo sapiens_hsa049301.10000323
38Pancreatic secretion_Homo sapiens_hsa049721.09059759
39Estrogen signaling pathway_Homo sapiens_hsa049151.07427825
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07282883
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06096800
42Arginine and proline metabolism_Homo sapiens_hsa003301.04436070
43Nitrogen metabolism_Homo sapiens_hsa009101.04396580
44Thyroid hormone synthesis_Homo sapiens_hsa049181.02027011
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00640332
46Vibrio cholerae infection_Homo sapiens_hsa051100.95560974
47Cardiac muscle contraction_Homo sapiens_hsa042600.95287984
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93024450
49Bile secretion_Homo sapiens_hsa049760.90332325
50Melanogenesis_Homo sapiens_hsa049160.88322701
51Tight junction_Homo sapiens_hsa045300.86267760
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84231316
53Alzheimers disease_Homo sapiens_hsa050100.82933564
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81945237
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.81865564
56Protein digestion and absorption_Homo sapiens_hsa049740.78624098
57Axon guidance_Homo sapiens_hsa043600.77315090
58Glioma_Homo sapiens_hsa052140.76928407
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76048223
60ErbB signaling pathway_Homo sapiens_hsa040120.74347341
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74263400
62Dorso-ventral axis formation_Homo sapiens_hsa043200.70604174
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69844280
64Inositol phosphate metabolism_Homo sapiens_hsa005620.68900535
65Phenylalanine metabolism_Homo sapiens_hsa003600.68144480
66Oxidative phosphorylation_Homo sapiens_hsa001900.66974005
67Hippo signaling pathway_Homo sapiens_hsa043900.66129579
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65651609
69Choline metabolism in cancer_Homo sapiens_hsa052310.65295816
70ECM-receptor interaction_Homo sapiens_hsa045120.65277509
71Phototransduction_Homo sapiens_hsa047440.64920004
72Adherens junction_Homo sapiens_hsa045200.61861991
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.60376788
74Glucagon signaling pathway_Homo sapiens_hsa049220.60152512
75Arginine biosynthesis_Homo sapiens_hsa002200.59931145
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59740780
77Oocyte meiosis_Homo sapiens_hsa041140.57029683
78beta-Alanine metabolism_Homo sapiens_hsa004100.56722791
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54334124
80African trypanosomiasis_Homo sapiens_hsa051430.53416860
81Butanoate metabolism_Homo sapiens_hsa006500.50682251
82MAPK signaling pathway_Homo sapiens_hsa040100.49634137
83Parkinsons disease_Homo sapiens_hsa050120.47201471
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47149560
85ABC transporters_Homo sapiens_hsa020100.44112558
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42480945
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42318076
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42291464
89Tyrosine metabolism_Homo sapiens_hsa003500.41433503
90VEGF signaling pathway_Homo sapiens_hsa043700.40828244
91Circadian rhythm_Homo sapiens_hsa047100.38514969
92Dilated cardiomyopathy_Homo sapiens_hsa054140.37093470
93Complement and coagulation cascades_Homo sapiens_hsa046100.36996253
94Endometrial cancer_Homo sapiens_hsa052130.36907915
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36573142
96Ovarian steroidogenesis_Homo sapiens_hsa049130.35499071
97AMPK signaling pathway_Homo sapiens_hsa041520.34925603
98Ras signaling pathway_Homo sapiens_hsa040140.34508974
99Alcoholism_Homo sapiens_hsa050340.34025148
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33694020
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.32217748
102Mineral absorption_Homo sapiens_hsa049780.31765595
103Rap1 signaling pathway_Homo sapiens_hsa040150.31764146
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30895632
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30860010
106Prion diseases_Homo sapiens_hsa050200.30843488
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.29411925
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.28651176
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27978242
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.27773645
111Focal adhesion_Homo sapiens_hsa045100.26678770
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26159407
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26028622
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25018626
115Fatty acid biosynthesis_Homo sapiens_hsa000610.23474608
116Huntingtons disease_Homo sapiens_hsa050160.23461090
117Insulin signaling pathway_Homo sapiens_hsa049100.23261446
118mTOR signaling pathway_Homo sapiens_hsa041500.22884541
119Glycerolipid metabolism_Homo sapiens_hsa005610.22834381
120Pyruvate metabolism_Homo sapiens_hsa006200.19747070
121Wnt signaling pathway_Homo sapiens_hsa043100.19711590

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