CALB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.41895167
2central nervous system myelination (GO:0022010)7.41895167
3negative regulation of execution phase of apoptosis (GO:1900118)6.99034382
4presynaptic membrane assembly (GO:0097105)6.15383607
5cerebellar Purkinje cell layer development (GO:0021680)6.11734280
6protein heterotetramerization (GO:0051290)6.03995582
7cerebellar Purkinje cell differentiation (GO:0021702)5.80344773
8presynaptic membrane organization (GO:0097090)5.75902063
9C4-dicarboxylate transport (GO:0015740)5.73192792
10neuron cell-cell adhesion (GO:0007158)5.60129821
11response to histamine (GO:0034776)5.54072299
12prepulse inhibition (GO:0060134)5.41452481
13cellular potassium ion homeostasis (GO:0030007)5.38803936
14neurofilament cytoskeleton organization (GO:0060052)5.38252862
15postsynaptic membrane organization (GO:0001941)5.37530759
16multicellular organismal movement (GO:0050879)5.25970245
17musculoskeletal movement (GO:0050881)5.25970245
18positive regulation of potassium ion transmembrane transporter activity (GO:1901018)5.25237763
19cell differentiation in hindbrain (GO:0021533)5.06868686
20positive regulation of synaptic transmission, GABAergic (GO:0032230)5.03777949
21cellular sodium ion homeostasis (GO:0006883)5.02489404
22fructose metabolic process (GO:0006000)5.01809224
23neuronal action potential propagation (GO:0019227)4.87621237
24positive regulation of protein kinase C signaling (GO:0090037)4.81120445
25positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.69442267
26regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.66302136
27limb bud formation (GO:0060174)4.60013438
28sodium ion export (GO:0071436)4.57039409
29positive regulation of muscle hypertrophy (GO:0014742)4.50723998
30positive regulation of cardiac muscle hypertrophy (GO:0010613)4.50723998
31positive regulation of dendritic spine morphogenesis (GO:0061003)4.48170546
32inositol phosphate-mediated signaling (GO:0048016)4.39928787
33retinal cone cell development (GO:0046549)4.32074751
34regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.31918032
35behavioral response to nicotine (GO:0035095)4.26887534
36G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.16713280
37oligodendrocyte differentiation (GO:0048709)4.13129328
38negative regulation of heart rate (GO:0010459)3.95337387
39negative regulation of norepinephrine secretion (GO:0010700)3.88487083
40innervation (GO:0060384)3.88149258
41regulation of potassium ion transmembrane transporter activity (GO:1901016)3.85114235
42mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.83054715
43positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.81315521
44positive regulation of glomerulus development (GO:0090193)3.79811760
45ionotropic glutamate receptor signaling pathway (GO:0035235)3.69615385
46relaxation of smooth muscle (GO:0044557)3.65499133
47negative regulation of neurotransmitter transport (GO:0051589)3.65207037
48neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.63922024
49protein localization to synapse (GO:0035418)3.63911910
50neuron remodeling (GO:0016322)3.60387278
51vocalization behavior (GO:0071625)3.56980906
52myelination (GO:0042552)3.56820215
53positive regulation of potassium ion transmembrane transport (GO:1901381)3.56072550
54regulation of timing of cell differentiation (GO:0048505)3.55995795
55negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.54405024
56ensheathment of neurons (GO:0007272)3.53186389
57axon ensheathment (GO:0008366)3.53186389
58transmission of nerve impulse (GO:0019226)3.52763088
59regulation of potassium ion transmembrane transport (GO:1901379)3.51644307
60aggressive behavior (GO:0002118)3.49436270
61positive regulation of synapse assembly (GO:0051965)3.48349688
62dopamine biosynthetic process (GO:0042416)3.45513867
63chemosensory behavior (GO:0007635)3.44557345
64regulation of protein kinase A signaling (GO:0010738)3.40796531
65regulation of development, heterochronic (GO:0040034)3.40150464
66glutamate receptor signaling pathway (GO:0007215)3.37952608
67neuron recognition (GO:0008038)3.36244628
68positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.36101248
69cerebral cortex radially oriented cell migration (GO:0021799)3.34032225
70negative regulation of protein localization to cell surface (GO:2000009)3.29278780
71regulation of centriole replication (GO:0046599)3.28008954
72layer formation in cerebral cortex (GO:0021819)3.27115011
73regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.26087276
74GMP metabolic process (GO:0046037)3.25908256
75lateral sprouting from an epithelium (GO:0060601)3.25355517
76eyelid development in camera-type eye (GO:0061029)3.25264392
77negative regulation of neurotransmitter secretion (GO:0046929)3.24092976
78locomotory exploration behavior (GO:0035641)3.23440489
79negative regulation of catecholamine secretion (GO:0033604)3.22890753
80regulation of excitatory postsynaptic membrane potential (GO:0060079)3.22164032
81adult walking behavior (GO:0007628)3.21130967
82serotonin metabolic process (GO:0042428)3.19035163
83apical protein localization (GO:0045176)3.18934658
84nonmotile primary cilium assembly (GO:0035058)3.18164680
85negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.18002934
86gamma-aminobutyric acid signaling pathway (GO:0007214)3.17347062
87organ growth (GO:0035265)3.16574703
88eye photoreceptor cell differentiation (GO:0001754)3.16390575
89photoreceptor cell differentiation (GO:0046530)3.16390575
90potassium ion homeostasis (GO:0055075)3.16056030
91acidic amino acid transport (GO:0015800)3.15564153
92positive regulation of protein tyrosine kinase activity (GO:0061098)3.14677254
93relaxation of cardiac muscle (GO:0055119)3.13470825
94behavioral response to cocaine (GO:0048148)3.11522682
95exploration behavior (GO:0035640)3.11378046
96auditory receptor cell stereocilium organization (GO:0060088)3.07976769
97long-chain fatty acid biosynthetic process (GO:0042759)3.07859841
98regulation of protein kinase C signaling (GO:0090036)3.05214961
99amino acid import (GO:0043090)3.05065338
100regulation of postsynaptic membrane potential (GO:0060078)3.04158531
101membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.02952594
102positive regulation of amino acid transport (GO:0051957)3.02575200
103cellular response to ammonium ion (GO:0071242)3.01444612
104regulation of glutamate receptor signaling pathway (GO:1900449)3.00098033
105enteric nervous system development (GO:0048484)2.98830367
106negative regulation of synaptic transmission, GABAergic (GO:0032229)2.97178562
107membrane depolarization during action potential (GO:0086010)2.96657931
108cerebellar granule cell differentiation (GO:0021707)2.96082357
109righting reflex (GO:0060013)2.95350597
110positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.94323180
111L-glutamate transport (GO:0015813)2.94136186
112negative regulation of keratinocyte proliferation (GO:0010839)2.93864287
113relaxation of muscle (GO:0090075)2.93198538
114cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.92738824
115endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.92036045
116cellular response to electrical stimulus (GO:0071257)2.91826716
117mating behavior (GO:0007617)2.91673941
118branch elongation of an epithelium (GO:0060602)2.89640100
119otic vesicle formation (GO:0030916)2.87747437
120negative regulation of cell fate commitment (GO:0010454)2.87639281
121cell communication by electrical coupling (GO:0010644)2.87218911
122auditory behavior (GO:0031223)2.87196661
123energy coupled proton transport, down electrochemical gradient (GO:0015985)2.86468172
124ATP synthesis coupled proton transport (GO:0015986)2.86468172
125sodium ion homeostasis (GO:0055078)2.84737613
126regulation of dopamine secretion (GO:0014059)2.84446671
127melanin biosynthetic process (GO:0042438)2.84247504
128L-amino acid import (GO:0043092)2.84131179
129regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.83807113
130regulation of pigment cell differentiation (GO:0050932)2.82316559
131heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.82285445
132spermatid nucleus differentiation (GO:0007289)2.81650676
133regulation of gene silencing by RNA (GO:0060966)2.81404000
134regulation of posttranscriptional gene silencing (GO:0060147)2.81404000
135regulation of gene silencing by miRNA (GO:0060964)2.81404000
136regulation of execution phase of apoptosis (GO:1900117)2.81233878
137startle response (GO:0001964)2.80086395
138mechanosensory behavior (GO:0007638)2.80082189
139membrane depolarization (GO:0051899)2.78771957
140melanin metabolic process (GO:0006582)2.78647635
141membrane assembly (GO:0071709)2.78356593
142regulation of amine transport (GO:0051952)2.78161740
143cGMP metabolic process (GO:0046068)2.77780249
144response to ammonium ion (GO:0060359)2.77520040
145response to methylmercury (GO:0051597)2.77191975
146* retina layer formation (GO:0010842)2.76928503
147G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.76459027
148glial cell differentiation (GO:0010001)2.74461443
149substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.74054299
150substrate-independent telencephalic tangential migration (GO:0021826)2.74054299
151parturition (GO:0007567)2.73999384
152negative regulation of Ras GTPase activity (GO:0034261)2.73749740
153synaptic transmission, glutamatergic (GO:0035249)2.73458394
154import into cell (GO:0098657)2.72731920
155mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.71333383
156spinal cord motor neuron differentiation (GO:0021522)2.69853322
157regulation of collateral sprouting (GO:0048670)2.69832230
158negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.69727614
159regulation of dendritic spine morphogenesis (GO:0061001)2.69056783
160long term synaptic depression (GO:0060292)2.67751272
161cranial nerve development (GO:0021545)2.67499193
162positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.66443228
163adult behavior (GO:0030534)2.65367161
164cochlea development (GO:0090102)2.64460059
165synapse assembly (GO:0007416)2.63668962
166negative regulation of axon extension (GO:0030517)2.63513081
167regulation of respiratory system process (GO:0044065)2.63325035
168regulation of synapse assembly (GO:0051963)2.62972186
169secondary metabolite biosynthetic process (GO:0044550)2.60534673
170forebrain neuron development (GO:0021884)2.60274903
171chondroitin sulfate catabolic process (GO:0030207)2.60061088
172forebrain neuron differentiation (GO:0021879)2.56819559
173positive regulation of dendritic spine development (GO:0060999)2.56634863
174mesenchymal cell differentiation involved in renal system development (GO:2001012)2.55046502
175mesenchymal cell differentiation involved in kidney development (GO:0072161)2.55046502
176* short-term memory (GO:0007614)2.51786492
177GTP biosynthetic process (GO:0006183)2.51679938
178neuron-neuron synaptic transmission (GO:0007270)2.51669816
179axonal fasciculation (GO:0007413)2.50353447
180cranial nerve morphogenesis (GO:0021602)2.49715889
181positive regulation of membrane potential (GO:0045838)2.49269110
182regulation of glutamate secretion (GO:0014048)2.48277716
183fatty acid elongation (GO:0030497)2.48232360
184gamma-aminobutyric acid transport (GO:0015812)2.46523957

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.54921010
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.80149037
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.42867015
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.41136604
5AR_21572438_ChIP-Seq_LNCaP_Human3.14400676
6EZH2_27304074_Chip-Seq_ESCs_Mouse3.10691520
7EED_16625203_ChIP-ChIP_MESCs_Mouse3.07621130
8* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05302099
9* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02858187
10GBX2_23144817_ChIP-Seq_PC3_Human2.96072676
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.90644481
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.90644481
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.86474924
14* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.81906037
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72652435
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62683607
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.53744690
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.45699800
19PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.39974811
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.29571421
21TAF15_26573619_Chip-Seq_HEK293_Human2.27861775
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.27848667
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24848876
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.22677300
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.15776730
26RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.15043767
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10059006
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.08703369
29* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.07979134
30* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.02714106
31ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02492238
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91307925
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88547834
34EWS_26573619_Chip-Seq_HEK293_Human1.78258099
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77022426
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76344698
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73756704
38CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71295457
39NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.70558720
40RNF2_27304074_Chip-Seq_NSC_Mouse1.70536067
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67218257
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.66535626
43TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65461529
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64420262
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.63087398
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59354509
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.53492091
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52276749
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.50172372
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50040077
51ER_23166858_ChIP-Seq_MCF-7_Human1.47636534
52BCAT_22108803_ChIP-Seq_LS180_Human1.47147656
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.46187084
54IRF1_19129219_ChIP-ChIP_H3396_Human1.44898182
55TRIM28_21343339_ChIP-Seq_HEK293_Human1.44109823
56RING1B_27294783_Chip-Seq_NPCs_Mouse1.43682479
57FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.42588763
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40621874
59P300_19829295_ChIP-Seq_ESCs_Human1.38010020
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.37554593
61* REST_21632747_ChIP-Seq_MESCs_Mouse1.37349538
62* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34535595
63IGF1R_20145208_ChIP-Seq_DFB_Human1.33510197
64GATA1_26923725_Chip-Seq_HPCs_Mouse1.33210698
65TCF4_23295773_ChIP-Seq_U87_Human1.32632525
66FUS_26573619_Chip-Seq_HEK293_Human1.31977357
67STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.28549884
68* VDR_22108803_ChIP-Seq_LS180_Human1.28418826
69SOX2_16153702_ChIP-ChIP_HESCs_Human1.28200606
70KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.27217003
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.25782954
72STAT3_23295773_ChIP-Seq_U87_Human1.25717060
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23214495
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20779277
75* SMAD4_21799915_ChIP-Seq_A2780_Human1.20769733
76TP53_20018659_ChIP-ChIP_R1E_Mouse1.20358193
77ZNF274_21170338_ChIP-Seq_K562_Hela1.19772278
78SOX9_26525672_Chip-Seq_HEART_Mouse1.19723165
79NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.19219012
80CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14560788
81TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13025423
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12888467
83TBX3_20139965_ChIP-Seq_ESCs_Mouse1.12385922
84RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11847517
85PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11520440
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11416084
87* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11356467
88* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10852820
89SMAD3_21741376_ChIP-Seq_ESCs_Human1.10547330
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09370067
91CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07405986
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06935765
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06727420
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06727420
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.05670258
96E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05531986
97TCF4_22108803_ChIP-Seq_LS180_Human1.05122070
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04449097
99* REST_18959480_ChIP-ChIP_MESCs_Mouse1.03990136
100SMAD4_21741376_ChIP-Seq_HESCs_Human1.03835916
101GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03583397
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.02460517
103KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.01328790
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99989449
105POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99928947
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99344108
107DROSHA_22980978_ChIP-Seq_HELA_Human0.99062920
108HTT_18923047_ChIP-ChIP_STHdh_Human0.98821088
109NFE2_27457419_Chip-Seq_LIVER_Mouse0.98406125
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97806781
111KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97663746
112KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.97663746
113KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97663746
114* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97609614
115HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96484316
116NANOG_16518401_ChIP-PET_MESCs_Mouse0.95830427
117JUN_21703547_ChIP-Seq_K562_Human0.95265963
118RUNX2_22187159_ChIP-Seq_PCA_Human0.94840032
119* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93592689
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93182056
121CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92337653
122P53_22387025_ChIP-Seq_ESCs_Mouse0.92202606
123YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92097457
124AR_19668381_ChIP-Seq_PC3_Human0.91803272
125* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91729294
126* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91362424
127E2F1_18555785_Chip-Seq_ESCs_Mouse0.90891745
128PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90781343
129WT1_19549856_ChIP-ChIP_CCG9911_Human0.90712579
130* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90653456
131ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90287137
132TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.89618237
133P300_18555785_Chip-Seq_ESCs_Mouse0.89513800
134AR_25329375_ChIP-Seq_VCAP_Human0.89496729
135ARNT_22903824_ChIP-Seq_MCF-7_Human0.89426188
136* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89341868
137RARB_27405468_Chip-Seq_BRAIN_Mouse0.89181969
138SUZ12_18555785_Chip-Seq_ESCs_Mouse0.85335948
139LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85303655
140* TAL1_26923725_Chip-Seq_HPCs_Mouse0.84905918
141EZH2_27294783_Chip-Seq_NPCs_Mouse0.84696477
142AHR_22903824_ChIP-Seq_MCF-7_Human0.84648400

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color6.27204233
2MP0003880_abnormal_central_pattern4.46834451
3MP0005409_darkened_coat_color4.16188521
4MP0001188_hyperpigmentation3.81151141
5MP0001984_abnormal_olfaction3.79506292
6MP0004381_abnormal_hair_follicle3.75595417
7MP0006035_abnormal_mitochondrial_morpho3.35765263
8MP0010386_abnormal_urinary_bladder3.28801754
9MP0005423_abnormal_somatic_nervous3.04295508
10MP0009379_abnormal_foot_pigmentation2.32453303
11MP0001968_abnormal_touch/_nociception2.28208892
12MP0006292_abnormal_olfactory_placode2.20803886
13MP0001486_abnormal_startle_reflex2.15384365
14MP0005171_absent_coat_pigmentation2.11940217
15MP0004270_analgesia2.06939417
16MP0008877_abnormal_DNA_methylation2.01900967
17MP0002102_abnormal_ear_morphology1.96686613
18MP0004859_abnormal_synaptic_plasticity1.96283105
19MP0000778_abnormal_nervous_system1.94107278
20MP0003635_abnormal_synaptic_transmissio1.93832506
21MP0000920_abnormal_myelination1.91513502
22MP0009745_abnormal_behavioral_response1.89899784
23* MP0002272_abnormal_nervous_system1.87692695
24MP0003938_abnormal_ear_development1.85019853
25MP0002064_seizures1.81738890
26MP0009046_muscle_twitch1.75018491
27MP0004142_abnormal_muscle_tone1.70536380
28MP0003787_abnormal_imprinting1.70375021
29* MP0004742_abnormal_vestibular_system1.70305048
30MP0008875_abnormal_xenobiotic_pharmacok1.66012510
31MP0003315_abnormal_perineum_morphology1.63383109
32MP0002734_abnormal_mechanical_nocicepti1.59680298
33* MP0002067_abnormal_sensory_capabilities1.56709692
34MP0003122_maternal_imprinting1.54729486
35MP0009250_abnormal_appendicular_skeleto1.52665778
36MP0001440_abnormal_grooming_behavior1.45594485
37MP0002249_abnormal_larynx_morphology1.45258069
38MP0000566_synostosis1.43988976
39MP0000049_abnormal_middle_ear1.40735182
40MP0003879_abnormal_hair_cell1.38905905
41MP0004145_abnormal_muscle_electrophysio1.36933859
42MP0002572_abnormal_emotion/affect_behav1.35983563
43MP0004215_abnormal_myocardial_fiber1.35538753
44MP0001970_abnormal_pain_threshold1.34289960
45MP0002184_abnormal_innervation1.33911449
46MP0003890_abnormal_embryonic-extraembry1.33798052
47MP0008874_decreased_physiological_sensi1.31817304
48MP0008872_abnormal_physiological_respon1.31153010
49MP0003011_delayed_dark_adaptation1.30780182
50MP0002736_abnormal_nociception_after1.28592107
51MP0002557_abnormal_social/conspecific_i1.28283227
52MP0004885_abnormal_endolymph1.28170304
53MP0003937_abnormal_limbs/digits/tail_de1.27753047
54MP0000026_abnormal_inner_ear1.27492434
55MP0008569_lethality_at_weaning1.27480603
56MP0002063_abnormal_learning/memory/cond1.26720172
57MP0002752_abnormal_somatic_nervous1.26285720
58MP0000631_abnormal_neuroendocrine_gland1.25722954
59MP0003950_abnormal_plasma_membrane1.23198360
60MP0004043_abnormal_pH_regulation1.22886138
61MP0009697_abnormal_copulation1.22723601
62MP0001905_abnormal_dopamine_level1.22405818
63MP0006276_abnormal_autonomic_nervous1.22243987
64MP0005551_abnormal_eye_electrophysiolog1.22208326
65* MP0002882_abnormal_neuron_morphology1.20982279
66MP0001485_abnormal_pinna_reflex1.20173843
67MP0005645_abnormal_hypothalamus_physiol1.12995808
68MP0000467_abnormal_esophagus_morphology1.12095792
69MP0002177_abnormal_outer_ear1.11830915
70MP0001299_abnormal_eye_distance/1.11254025
71MP0002282_abnormal_trachea_morphology1.10208314
72MP0002733_abnormal_thermal_nociception1.09689911
73MP0004036_abnormal_muscle_relaxation1.06534909
74MP0000358_abnormal_cell_content/1.06431243
75MP0001963_abnormal_hearing_physiology1.06428008
76MP0003121_genomic_imprinting1.06346636
77MP0003123_paternal_imprinting1.06120802
78MP0002751_abnormal_autonomic_nervous1.05682955
79MP0004133_heterotaxia1.03312674
80MP0004484_altered_response_of1.03173335
81MP0002254_reproductive_system_inflammat1.03072473
82MP0001529_abnormal_vocalization1.01810933
83MP0001501_abnormal_sleep_pattern1.01176212
84MP0003634_abnormal_glial_cell1.00180326
85MP0002638_abnormal_pupillary_reflex0.99539200
86MP0003567_abnormal_fetal_cardiomyocyte0.99150639
87MP0006072_abnormal_retinal_apoptosis0.98999199
88MP0001177_atelectasis0.98524951
89MP0002735_abnormal_chemical_nociception0.98415565
90* MP0002066_abnormal_motor_capabilities/c0.98153902
91MP0004084_abnormal_cardiac_muscle0.96529170
92* MP0002152_abnormal_brain_morphology0.96294521
93MP0008260_abnormal_autophagy0.96220906
94MP0000955_abnormal_spinal_cord0.95977303
95MP0002229_neurodegeneration0.94268139
96MP0001340_abnormal_eyelid_morphology0.94168496
97MP0005620_abnormal_muscle_contractility0.93660294
98MP0000762_abnormal_tongue_morphology0.93178107
99MP0002277_abnormal_respiratory_mucosa0.92701743
100MP0003755_abnormal_palate_morphology0.92103191
101MP0000015_abnormal_ear_pigmentation0.91072988
102MP0005410_abnormal_fertilization0.89601556
103MP0005187_abnormal_penis_morphology0.89516834
104MP0004957_abnormal_blastocyst_morpholog0.89329910
105MP0004085_abnormal_heartbeat0.88924816
106MP0002233_abnormal_nose_morphology0.88574199
107MP0003385_abnormal_body_wall0.87743377
108MP0005174_abnormal_tail_pigmentation0.87517272
109MP0003941_abnormal_skin_development0.86825172
110MP0003861_abnormal_nervous_system0.85520601
111MP0000579_abnormal_nail_morphology0.84332263
112MP0003119_abnormal_digestive_system0.84251071
113MP0001346_abnormal_lacrimal_gland0.83534665
114MP0002697_abnormal_eye_size0.82601268
115MP0003718_maternal_effect0.82045540
116MP0002090_abnormal_vision0.80491049
117MP0003690_abnormal_glial_cell0.79201209
118MP0000428_abnormal_craniofacial_morphol0.79036418
119MP0001502_abnormal_circadian_rhythm0.78814420
120MP0005195_abnormal_posterior_eye0.78441507
121MP0002938_white_spotting0.77894529
122MP0000534_abnormal_ureter_morphology0.77890239
123MP0005379_endocrine/exocrine_gland_phen0.77669379
124MP0002116_abnormal_craniofacial_bone0.77129548
125MP0005623_abnormal_meninges_morphology0.76912922
126MP0005595_abnormal_vascular_smooth0.75190887
127* MP0004811_abnormal_neuron_physiology0.73460128
128MP0003693_abnormal_embryo_hatching0.71936431
129MP0004924_abnormal_behavior0.71078371
130MP0005386_behavior/neurological_phenoty0.71078371
131MP0008058_abnormal_DNA_repair0.70259589
132MP0004147_increased_porphyrin_level0.68347906
133MP0000432_abnormal_head_morphology0.67949721
134MP0000462_abnormal_digestive_system0.67874135
135MP0000013_abnormal_adipose_tissue0.67565952
136MP0002163_abnormal_gland_morphology0.64230972
137MP0000751_myopathy0.63923552
138MP0003137_abnormal_impulse_conducting0.63904720
139MP0003935_abnormal_craniofacial_develop0.63271807
140MP0005253_abnormal_eye_physiology0.62584593
141MP0008932_abnormal_embryonic_tissue0.60515182
142MP0009672_abnormal_birth_weight0.60095319
143MP0009384_cardiac_valve_regurgitation0.58959761
144MP0008770_decreased_survivor_rate0.58319052
145MP0003633_abnormal_nervous_system0.57956670
146MP0001286_abnormal_eye_development0.57643443
147MP0003303_peritoneal_inflammation0.57498536
148MP0003698_abnormal_male_reproductive0.57451541
149MP0010770_preweaning_lethality0.56495749

Predicted human phenotypes

RankGene SetZ-score
1Febrile seizures (HP:0002373)8.43950968
2Dysmetric saccades (HP:0000641)7.66286087
3Scanning speech (HP:0002168)7.29274752
4Absence seizures (HP:0002121)6.39048296
5Dysdiadochokinesis (HP:0002075)5.88009758
6Progressive cerebellar ataxia (HP:0002073)5.67010880
7Dialeptic seizures (HP:0011146)5.47729288
8Gaze-evoked nystagmus (HP:0000640)5.41602687
9Horizontal nystagmus (HP:0000666)5.26292604
10Obstructive sleep apnea (HP:0002870)5.22424624
11Abnormal sex determination (HP:0012244)4.67824301
12Sex reversal (HP:0012245)4.67824301
13Postural tremor (HP:0002174)4.55561341
14Septo-optic dysplasia (HP:0100842)4.38940301
15Abnormality of secondary sexual hair (HP:0009888)4.35997806
16Abnormality of the axillary hair (HP:0100134)4.35997806
17Truncal ataxia (HP:0002078)4.23314298
18Intention tremor (HP:0002080)4.18868881
19Impaired vibration sensation in the lower limbs (HP:0002166)4.18329297
20Impaired smooth pursuit (HP:0007772)4.06830707
21Alacrima (HP:0000522)4.04377997
22Focal motor seizures (HP:0011153)3.97871097
23Concave nail (HP:0001598)3.67384677
24Peripheral hypomyelination (HP:0007182)3.61439051
25Absent septum pellucidum (HP:0001331)3.57543343
26Decreased lacrimation (HP:0000633)3.46867238
27Sleep apnea (HP:0010535)3.34774223
28Abnormality of the septum pellucidum (HP:0007375)3.32760456
29Abnormality of ocular smooth pursuit (HP:0000617)3.31291989
30Broad-based gait (HP:0002136)3.28740178
31Generalized tonic-clonic seizures (HP:0002069)3.28073975
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.26267223
33Abnormality of saccadic eye movements (HP:0000570)3.24506269
34Absent speech (HP:0001344)3.24307675
35Optic nerve hypoplasia (HP:0000609)3.23134679
36Acute necrotizing encephalopathy (HP:0006965)3.05263721
37Split foot (HP:0001839)3.04337487
38Cerebral hypomyelination (HP:0006808)2.90661916
39Humeroradial synostosis (HP:0003041)2.82755466
40Synostosis involving the elbow (HP:0003938)2.82755466
41Limb ataxia (HP:0002070)2.76821639
42Abnormality of the labia minora (HP:0012880)2.70890735
43Chin dimple (HP:0010751)2.68916990
44Abnormal mitochondria in muscle tissue (HP:0008316)2.68380083
45Neurofibrillary tangles (HP:0002185)2.64624998
46Abnormal ciliary motility (HP:0012262)2.63848950
47Abnormal respiratory motile cilium physiology (HP:0012261)2.63326881
48Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.61104964
49Absent/shortened dynein arms (HP:0200106)2.60930152
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.60930152
51Esotropia (HP:0000565)2.60746838
52Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.59553821
53Acute encephalopathy (HP:0006846)2.58739314
54Progressive macrocephaly (HP:0004481)2.56860033
55Hemiparesis (HP:0001269)2.51762946
56Gait ataxia (HP:0002066)2.50885619
57Hypoplastic pelvis (HP:0008839)2.47313936
58Attenuation of retinal blood vessels (HP:0007843)2.46058416
59White forelock (HP:0002211)2.43241260
60Degeneration of the lateral corticospinal tracts (HP:0002314)2.42442398
61Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.42442398
62Impaired vibratory sensation (HP:0002495)2.41888195
63Morphological abnormality of the inner ear (HP:0011390)2.41576011
64Parakeratosis (HP:0001036)2.38012761
65Supernumerary spleens (HP:0009799)2.35397408
66Increased hepatocellular lipid droplets (HP:0006565)2.31955040
67Patchy hypopigmentation of hair (HP:0011365)2.29060478
68Partial duplication of the phalanx of hand (HP:0009999)2.27246356
69Status epilepticus (HP:0002133)2.26183140
70Partial duplication of thumb phalanx (HP:0009944)2.25352577
71Optic disc pallor (HP:0000543)2.24175012
72Maternal diabetes (HP:0009800)2.23427799
73Congenital malformation of the right heart (HP:0011723)2.19808453
74Double outlet right ventricle (HP:0001719)2.19808453
75Aplasia/hypoplasia of the uterus (HP:0008684)2.19009697
76Intellectual disability, moderate (HP:0002342)2.18283044
77Mitochondrial inheritance (HP:0001427)2.16605050
78Abnormal respiratory epithelium morphology (HP:0012253)2.16426465
79Abnormal respiratory motile cilium morphology (HP:0005938)2.16426465
80Generalized hypotonia (HP:0001290)2.14566272
81Dysmetria (HP:0001310)2.11781737
82Asplenia (HP:0001746)2.11679076
83Abnormal auditory evoked potentials (HP:0006958)2.10744091
84Hyperventilation (HP:0002883)2.10423550
85Myokymia (HP:0002411)2.08249935
86Congenital sensorineural hearing impairment (HP:0008527)2.08045764
87Hypoplasia of the iris (HP:0007676)2.07150969
88Increased serum pyruvate (HP:0003542)2.05956623
89Overfolded helix (HP:0000396)2.04132284
90Focal seizures (HP:0007359)2.03423365
91Short tibia (HP:0005736)2.01315740
92Mixed hearing impairment (HP:0000410)2.01061190
93Atonic seizures (HP:0010819)1.97810710
94Nephronophthisis (HP:0000090)1.96551720
95Aplasia/Hypoplasia of the spleen (HP:0010451)1.95719722
96Lipid accumulation in hepatocytes (HP:0006561)1.95167727
97Cupped ear (HP:0000378)1.94894315
98Abnormality of the phalanges of the 2nd finger (HP:0009541)1.94373170
99Hypomagnesemia (HP:0002917)1.92319556
100Sensory axonal neuropathy (HP:0003390)1.91754421
101Excessive salivation (HP:0003781)1.90661738
102Drooling (HP:0002307)1.90661738
103Abnormally folded helix (HP:0008544)1.90101635
104Confusion (HP:0001289)1.87267335
105Increased circulating renin level (HP:0000848)1.86825277
106Progressive inability to walk (HP:0002505)1.86078451
107Laryngomalacia (HP:0001601)1.85830852
108Limb dystonia (HP:0002451)1.85451897
109Long nose (HP:0003189)1.83980321
110Cerebellar atrophy (HP:0001272)1.83607787
111CNS hypomyelination (HP:0003429)1.83491620
112Cerebral edema (HP:0002181)1.83167766
113Leukodystrophy (HP:0002415)1.83143756
114Abnormality of the anterior horn cell (HP:0006802)1.82978121
115Degeneration of anterior horn cells (HP:0002398)1.82978121
116Increased CSF lactate (HP:0002490)1.82079015
117Abnormality of glycolysis (HP:0004366)1.79824741
118Fibular aplasia (HP:0002990)1.79800261
119Aplasia involving bones of the upper limbs (HP:0009823)1.79721573
120Aplasia of the phalanges of the hand (HP:0009802)1.79721573
121Aplasia involving bones of the extremities (HP:0009825)1.79721573
122Abnormality of binocular vision (HP:0011514)1.78937132
123Diplopia (HP:0000651)1.78937132
124Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78910330
125Focal dystonia (HP:0004373)1.78739265
126Action tremor (HP:0002345)1.78088789
127Metabolic alkalosis (HP:0200114)1.78045637
128Rhinitis (HP:0012384)1.77545095
129Conical tooth (HP:0000698)1.76102071
130Aplasia/Hypoplasia of the tibia (HP:0005772)1.75807388
131Esophageal atresia (HP:0002032)1.75757796
132Abnormality of the corticospinal tract (HP:0002492)1.75653019
133Thyroid-stimulating hormone excess (HP:0002925)1.74916867
134Autoamputation (HP:0001218)1.73966874
135Cutaneous finger syndactyly (HP:0010554)1.73545664
136Symphalangism affecting the phalanges of the hand (HP:0009773)1.73205275
137Delayed myelination (HP:0012448)1.72190924
138Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.71962270
139Bowel incontinence (HP:0002607)1.70627256
140Epileptic encephalopathy (HP:0200134)1.70397984
141Supranuclear gaze palsy (HP:0000605)1.69506274
142Aplasia involving forearm bones (HP:0009822)1.69058445
143Absent forearm bone (HP:0003953)1.69058445
144Abnormality of the middle phalanges of the toes (HP:0010183)1.68088164
145Amblyopia (HP:0000646)1.67654858
146Vaginal atresia (HP:0000148)1.67056897
147Dysarthria (HP:0001260)1.65282690
148Renal Fanconi syndrome (HP:0001994)1.64548139
149Epileptiform EEG discharges (HP:0011182)1.64518821
150Cutaneous syndactyly (HP:0012725)1.59490813
151Termporal pattern (HP:0011008)1.58974997
152Insidious onset (HP:0003587)1.58974997
153EEG with generalized epileptiform discharges (HP:0011198)1.57408525
154Depression (HP:0000716)1.56649800
155Inability to walk (HP:0002540)1.52125168
156Genital tract atresia (HP:0001827)1.50668088
157Slow progression (HP:0003677)1.46740420
158Hyperglycinemia (HP:0002154)1.46282257
159Urinary urgency (HP:0000012)1.44115334
160Bilateral microphthalmos (HP:0007633)1.43249947
161Morphological abnormality of the pyramidal tract (HP:0002062)1.42713472
162Spastic diplegia (HP:0001264)1.42455794
163Dysphonia (HP:0001618)1.39713878
164Abnormality of renal resorption (HP:0011038)1.39288295
165Hyperactive renin-angiotensin system (HP:0000841)1.39082773
166Bifid tongue (HP:0010297)1.38835108
167Colon cancer (HP:0003003)1.38211219
168Methylmalonic acidemia (HP:0002912)1.37289826
169Athetosis (HP:0002305)1.34907610
170X-linked dominant inheritance (HP:0001423)1.33626591
171Labial hypoplasia (HP:0000066)1.32640101
172Abnormality of serum amino acid levels (HP:0003112)1.32379713
173Urinary bladder sphincter dysfunction (HP:0002839)1.32144800
174Abnormality of alanine metabolism (HP:0010916)1.31627855
175Hyperalaninemia (HP:0003348)1.31627855
176Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.31627855
177Abnormal hair whorl (HP:0010721)1.29798662
178Absent eyebrow (HP:0002223)1.28623643
179Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.28581966
180Increased intramyocellular lipid droplets (HP:0012240)1.27714177

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK9.45877172
2MAP3K125.56754067
3MAP3K93.76414645
4TTK3.74486384
5PHKG23.72765216
6PHKG13.72765216
7MKNK23.43216852
8TLK13.34931955
9TSSK62.67853817
10STK392.39988330
11PNCK2.39742458
12PKN12.02654567
13BLK1.99906801
14OXSR11.85406112
15TAF11.84851724
16NTRK31.83964894
17PINK11.77298798
18MAPK151.73633153
19MKNK11.67950855
20WNK31.63186006
21NLK1.55838412
22FES1.50788219
23MAP3K41.49250938
24NEK11.46246501
25BUB11.45585656
26TRIM281.43512290
27MINK11.41744478
28MYLK1.39911935
29PAK41.35789577
30TNIK1.33542034
31CDC71.28776596
32CSNK1G11.27946083
33PLK31.26790277
34DYRK21.24370765
35ARAF1.23727072
36GRK11.22310981
37PAK21.19761983
38DYRK1A1.18497116
39PRKG21.16773873
40IRAK11.14698080
41IRAK21.11488821
42CAMK2B1.05352498
43PTK61.04077853
44PBK1.03916997
45DAPK11.03651303
46ZAK0.99030910
47YES10.96440554
48STK38L0.95777436
49MAPKAPK50.95051710
50UHMK10.94512380
51WNK40.94155681
52ROCK20.93766395
53NTRK20.92169573
54CLK10.90067799
55EPHA40.89265656
56FGR0.87083189
57CHEK20.86407124
58FER0.84980023
59SGK2230.83524073
60SGK4940.83524073
61CDK190.79683820
62BCR0.79606183
63PLK10.78979274
64PLK20.78390206
65MAP3K10.77771841
66GRK70.77704453
67PRKDC0.76761018
68NEK60.76589167
69MARK10.76064455
70PRPF4B0.75608897
71TESK20.73789243
72BRAF0.72831067
73GSK3A0.71425759
74DAPK30.70336553
75MAP2K70.69148082
76CAMK2A0.68788966
77PRKG10.67994692
78CDK30.67897504
79MST40.67058440
80STK160.66265076
81MAPK130.64085491
82FGFR20.63567967
83CAMK2D0.62481429
84VRK20.59872735
85CAMK2G0.59371790
86PRKAA20.59077874
87PAK10.58714160
88NTRK10.57917800
89EIF2AK30.57286632
90PLK40.57194073
91CDK50.55948921
92WNK10.55077585
93ALK0.53963585
94PRKD10.53940071
95PRKCA0.53726248
96NUAK10.52963321
97CSNK1G30.52935634
98SRPK10.52567372
99DDR20.52305545
100DYRK30.52067304
101WEE10.51835009
102TYRO30.51538087
103FGFR10.51451391
104PAK60.50817367
105NME10.50543485
106STK110.49961155
107CSNK1E0.49324767
108EPHB10.48923152
109CDK180.48849558
110HIPK20.47688132
111PRKCE0.47565703
112MAP2K20.46253584
113CAMKK20.46239995
114RPS6KA50.45888858
115DMPK0.45798991
116RPS6KA30.45700960
117CAMK1G0.45246941
118LATS10.44961616
119PASK0.44716220
120CDK150.43975569
121EIF2AK20.43686502
122TESK10.43513152
123KSR10.43494228
124PRKD20.42702710
125CSNK1G20.42093054
126ADRBK20.42077424
127GRK50.40276421
128PRKCB0.39939829
129LIMK10.39692539
130EIF2AK10.38568932
131CDK11A0.37237795
132CSNK1A10.37125161
133CSNK1A1L0.36686935
134ATM0.36233494
135CDK10.36171961
136IRAK40.35986538
137MUSK0.35732655
138MAPK100.35438797
139ATR0.34608828
140MARK20.33504242
141LATS20.32110821
142MET0.32086938
143PRKACA0.30588221
144BMPR1B0.30383305
145CAMK10.29631408
146ERBB40.29523491
147CSNK1D0.28854349
148ILK0.28480886
149PRKCG0.27387796
150FYN0.26607056
151VRK10.25323427
152CDK140.24338617
153SGK10.23308692
154TNK20.23304991
155SGK20.22998819
156PAK30.22172961

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.67268458
2Phototransduction_Homo sapiens_hsa047442.69071930
3Long-term depression_Homo sapiens_hsa047302.51761460
4Axon guidance_Homo sapiens_hsa043602.50955976
5Glutamatergic synapse_Homo sapiens_hsa047242.41724565
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.32961943
7Cell adhesion molecules (CAMs)_Homo sapiens_hsa045142.23412985
8Sphingolipid metabolism_Homo sapiens_hsa006002.07648235
9Morphine addiction_Homo sapiens_hsa050322.02584094
10GABAergic synapse_Homo sapiens_hsa047272.02147461
11Taste transduction_Homo sapiens_hsa047421.89507754
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.80900789
13Protein export_Homo sapiens_hsa030601.79666104
14Serotonergic synapse_Homo sapiens_hsa047261.79516837
15Ether lipid metabolism_Homo sapiens_hsa005651.78075526
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.75161081
17Cocaine addiction_Homo sapiens_hsa050301.72770977
18Salivary secretion_Homo sapiens_hsa049701.66008037
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65665072
20Amphetamine addiction_Homo sapiens_hsa050311.63777687
21Oxidative phosphorylation_Homo sapiens_hsa001901.62848267
22Melanogenesis_Homo sapiens_hsa049161.60035703
23Cardiac muscle contraction_Homo sapiens_hsa042601.51660443
24Circadian entrainment_Homo sapiens_hsa047131.51002844
25Pentose phosphate pathway_Homo sapiens_hsa000301.49931845
26RNA polymerase_Homo sapiens_hsa030201.46069309
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43911170
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.40525583
29Hedgehog signaling pathway_Homo sapiens_hsa043401.39173601
30Long-term potentiation_Homo sapiens_hsa047201.38920528
31Calcium signaling pathway_Homo sapiens_hsa040201.36364395
32Gastric acid secretion_Homo sapiens_hsa049711.36226383
33Dopaminergic synapse_Homo sapiens_hsa047281.31340930
34Gap junction_Homo sapiens_hsa045401.30563639
35Basal cell carcinoma_Homo sapiens_hsa052171.28753969
36Ribosome_Homo sapiens_hsa030101.26502162
37Renal cell carcinoma_Homo sapiens_hsa052111.25788897
38Renin secretion_Homo sapiens_hsa049241.22434344
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22371081
40Wnt signaling pathway_Homo sapiens_hsa043101.20762608
41Fructose and mannose metabolism_Homo sapiens_hsa000511.18302013
42GnRH signaling pathway_Homo sapiens_hsa049121.13155639
43Oocyte meiosis_Homo sapiens_hsa041141.10800139
44Alzheimers disease_Homo sapiens_hsa050101.07974783
45Fatty acid elongation_Homo sapiens_hsa000621.07881668
46ErbB signaling pathway_Homo sapiens_hsa040121.06391372
47Pyruvate metabolism_Homo sapiens_hsa006201.05784217
48Dorso-ventral axis formation_Homo sapiens_hsa043201.05259370
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04921612
50Parkinsons disease_Homo sapiens_hsa050121.03805202
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02534698
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.00377688
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98661038
54MAPK signaling pathway_Homo sapiens_hsa040100.98076366
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96715341
56Cholinergic synapse_Homo sapiens_hsa047250.96443540
57Huntingtons disease_Homo sapiens_hsa050160.95169900
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94113331
59Oxytocin signaling pathway_Homo sapiens_hsa049210.92427885
60Insulin secretion_Homo sapiens_hsa049110.90931940
61Other glycan degradation_Homo sapiens_hsa005110.89874443
62Ras signaling pathway_Homo sapiens_hsa040140.89058367
63Pancreatic secretion_Homo sapiens_hsa049720.88629214
64Olfactory transduction_Homo sapiens_hsa047400.88349597
65Biosynthesis of amino acids_Homo sapiens_hsa012300.87477298
66Linoleic acid metabolism_Homo sapiens_hsa005910.86540157
67Circadian rhythm_Homo sapiens_hsa047100.85428850
68Arachidonic acid metabolism_Homo sapiens_hsa005900.84811720
69Renin-angiotensin system_Homo sapiens_hsa046140.83036278
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.81106144
71Spliceosome_Homo sapiens_hsa030400.80722642
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79495137
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79022516
74cAMP signaling pathway_Homo sapiens_hsa040240.78653783
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78458758
76Proteasome_Homo sapiens_hsa030500.77674560
77Carbon metabolism_Homo sapiens_hsa012000.77505842
78Fanconi anemia pathway_Homo sapiens_hsa034600.76187297
79Estrogen signaling pathway_Homo sapiens_hsa049150.74466259
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.71423775
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71063854
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70044702
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69952205
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68874042
85Synaptic vesicle cycle_Homo sapiens_hsa047210.67553323
86Tight junction_Homo sapiens_hsa045300.67133908
87Sulfur relay system_Homo sapiens_hsa041220.66773741
88Autoimmune thyroid disease_Homo sapiens_hsa053200.66286334
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.64235764
90Choline metabolism in cancer_Homo sapiens_hsa052310.61421548
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60614908
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60096892
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59686671
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58606743
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58584956
96Vibrio cholerae infection_Homo sapiens_hsa051100.57821627
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57753749
98Collecting duct acid secretion_Homo sapiens_hsa049660.57330506
99Mismatch repair_Homo sapiens_hsa034300.56073538
100Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56019217
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55376673
102Alcoholism_Homo sapiens_hsa050340.54809584
103Prostate cancer_Homo sapiens_hsa052150.54346482
104Nitrogen metabolism_Homo sapiens_hsa009100.53891658
105Melanoma_Homo sapiens_hsa052180.53748936
106Dilated cardiomyopathy_Homo sapiens_hsa054140.53689809
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53524774
108Mineral absorption_Homo sapiens_hsa049780.53265431
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50553587
110MicroRNAs in cancer_Homo sapiens_hsa052060.50116492
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49439753
112Thyroid hormone synthesis_Homo sapiens_hsa049180.48489914
113Glycerolipid metabolism_Homo sapiens_hsa005610.47299083
114Selenocompound metabolism_Homo sapiens_hsa004500.46534947
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45276818
116Arginine and proline metabolism_Homo sapiens_hsa003300.43051341
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41452303
118* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40519439
119Propanoate metabolism_Homo sapiens_hsa006400.39985906
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.39630919
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36629475
122Basal transcription factors_Homo sapiens_hsa030220.36585656
123Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36356545
124RNA transport_Homo sapiens_hsa030130.35990245
125Vitamin digestion and absorption_Homo sapiens_hsa049770.35275621
126Cell cycle_Homo sapiens_hsa041100.35261934
127Histidine metabolism_Homo sapiens_hsa003400.35049529
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34669331
129Rap1 signaling pathway_Homo sapiens_hsa040150.34570191
130Glucagon signaling pathway_Homo sapiens_hsa049220.34228847
131Hippo signaling pathway_Homo sapiens_hsa043900.33994244
132Non-homologous end-joining_Homo sapiens_hsa034500.33544043
133Folate biosynthesis_Homo sapiens_hsa007900.32650278
1342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30113136
135Vitamin B6 metabolism_Homo sapiens_hsa007500.27794438
136African trypanosomiasis_Homo sapiens_hsa051430.27384998
137Metabolic pathways_Homo sapiens_hsa011000.21273681
138RNA degradation_Homo sapiens_hsa030180.19664203
139mRNA surveillance pathway_Homo sapiens_hsa030150.18691659
140Fatty acid metabolism_Homo sapiens_hsa012120.18508721
141Adherens junction_Homo sapiens_hsa045200.18332929

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