CALB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.91967768
2locomotory exploration behavior (GO:0035641)5.90566497
3synaptic vesicle maturation (GO:0016188)5.78808090
4response to pheromone (GO:0019236)5.73526598
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.46335824
6gamma-aminobutyric acid transport (GO:0015812)5.40108508
7regulation of synaptic vesicle exocytosis (GO:2000300)5.37964633
8synaptic vesicle exocytosis (GO:0016079)5.32295315
9neurotransmitter secretion (GO:0007269)5.26823163
10cerebellar granule cell differentiation (GO:0021707)5.23656021
11low-density lipoprotein particle clearance (GO:0034383)5.21513956
12vocalization behavior (GO:0071625)5.19524336
13neuronal action potential propagation (GO:0019227)5.15775041
14response to dietary excess (GO:0002021)5.11518823
15glutamate secretion (GO:0014047)4.87736967
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.85688252
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.83869225
18neuron cell-cell adhesion (GO:0007158)4.76419933
19cerebellar Purkinje cell differentiation (GO:0021702)4.72586904
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.71327929
21regulation of synaptic vesicle transport (GO:1902803)4.67659882
22cellular potassium ion homeostasis (GO:0030007)4.57081389
23regulation of glutamate receptor signaling pathway (GO:1900449)4.55649873
24glutamate receptor signaling pathway (GO:0007215)4.47244753
25neuromuscular process controlling posture (GO:0050884)4.44571273
26regulation of sequestering of triglyceride (GO:0010889)4.42736269
27synaptic transmission, glutamatergic (GO:0035249)4.42558637
28neurotransmitter transport (GO:0006836)4.30377698
29sodium ion export (GO:0071436)4.30370018
30exploration behavior (GO:0035640)4.29108568
31neuron-neuron synaptic transmission (GO:0007270)4.28697867
32regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.22654226
33G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.19593965
34triglyceride catabolic process (GO:0019433)4.14402199
35neurotransmitter-gated ion channel clustering (GO:0072578)4.13325292
36layer formation in cerebral cortex (GO:0021819)4.11366260
37positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.10883570
38gamma-aminobutyric acid signaling pathway (GO:0007214)4.02432410
39auditory behavior (GO:0031223)4.00519869
40regulation of neurotransmitter levels (GO:0001505)3.99794832
41positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.96540453
42cell differentiation in hindbrain (GO:0021533)3.95960666
43regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.95854883
44positive regulation of synapse maturation (GO:0090129)3.95339667
45synaptic vesicle docking involved in exocytosis (GO:0016081)3.94725836
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.90652231
47negative regulation of synaptic transmission, GABAergic (GO:0032229)3.89712022
48protein localization to synapse (GO:0035418)3.88683317
49regulation of cAMP-dependent protein kinase activity (GO:2000479)3.87143662
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.84790263
51collecting duct development (GO:0072044)3.84750691
52long-term memory (GO:0007616)3.79637667
53acylglycerol catabolic process (GO:0046464)3.78799028
54neutral lipid catabolic process (GO:0046461)3.78799028
55neuronal ion channel clustering (GO:0045161)3.77345627
56positive regulation of vesicle fusion (GO:0031340)3.74637566
57negative regulation of amino acid transport (GO:0051956)3.72580667
58pyrimidine nucleobase catabolic process (GO:0006208)3.68580775
59activation of protein kinase A activity (GO:0034199)3.60999759
60synaptic vesicle endocytosis (GO:0048488)3.60337741
61regulation of long-term neuronal synaptic plasticity (GO:0048169)3.55133251
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.53608589
63establishment of mitochondrion localization (GO:0051654)3.53484616
64regulation of glycogen (starch) synthase activity (GO:2000465)3.53426114
65adult walking behavior (GO:0007628)3.50943316
66proline transport (GO:0015824)3.50825889
67regulation of gonadotropin secretion (GO:0032276)3.49238601
68dendritic spine morphogenesis (GO:0060997)3.47292684
69detection of calcium ion (GO:0005513)3.46909474
70cell communication by electrical coupling (GO:0010644)3.45164283
71glycine transport (GO:0015816)3.43447111
72regulation of neurotransmitter secretion (GO:0046928)3.42667972
73neuromuscular process controlling balance (GO:0050885)3.41567515
74positive regulation of potassium ion transmembrane transport (GO:1901381)3.40313500
75regulation of neuronal synaptic plasticity (GO:0048168)3.40045275
76transmission of nerve impulse (GO:0019226)3.36424275
77cell migration in hindbrain (GO:0021535)3.34488493
78regulation of excitatory postsynaptic membrane potential (GO:0060079)3.33097062
79membrane depolarization during action potential (GO:0086010)3.32616164
80potassium ion import (GO:0010107)3.32576899
81potassium ion homeostasis (GO:0055075)3.32279328
82nucleobase catabolic process (GO:0046113)3.31457547
83regulation of synapse structural plasticity (GO:0051823)3.30395872
84positive regulation of membrane potential (GO:0045838)3.26782243
85negative regulation of microtubule polymerization (GO:0031115)3.25624479
86positive regulation of synapse assembly (GO:0051965)3.24885985
87postsynaptic membrane organization (GO:0001941)3.24676540
88regulation of neurotransmitter transport (GO:0051588)3.21165176
89regulation of synaptic transmission, glutamatergic (GO:0051966)3.20364010
90regulation of postsynaptic membrane potential (GO:0060078)3.19729300
91glycerolipid catabolic process (GO:0046503)3.18812412
92regulation of synapse maturation (GO:0090128)3.18142403
93long-term synaptic potentiation (GO:0060291)3.18070143
94synapse assembly (GO:0007416)3.15714414
95neuron recognition (GO:0008038)3.15609110
96neuromuscular synaptic transmission (GO:0007274)3.15016502
97membrane hyperpolarization (GO:0060081)3.14274201
98positive regulation of synaptic transmission, GABAergic (GO:0032230)3.13654172
99synaptic transmission (GO:0007268)3.12693086
100mating behavior (GO:0007617)3.12237225
101regulation of voltage-gated calcium channel activity (GO:1901385)3.12217499
102neuromuscular process (GO:0050905)3.11935618
103acidic amino acid transport (GO:0015800)3.11654696
104regulation of vesicle fusion (GO:0031338)3.11532212
105sympathetic nervous system development (GO:0048485)3.11416137
106cellular response to epinephrine stimulus (GO:0071872)3.09867793
107lipid particle organization (GO:0034389)3.08991261
108protein heterotrimerization (GO:0070208)3.07758706
109positive regulation of dendritic spine development (GO:0060999)3.07279771
110membrane depolarization (GO:0051899)3.05883122
111cerebellar Purkinje cell layer development (GO:0021680)3.05867214
112cellular response to catecholamine stimulus (GO:0071870)3.05594137
113cellular response to monoamine stimulus (GO:0071868)3.05594137
114axon extension (GO:0048675)3.05165221
115behavioral response to ethanol (GO:0048149)3.02065891
116response to auditory stimulus (GO:0010996)2.99383345
117CDP-diacylglycerol metabolic process (GO:0046341)2.99206514
118negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.98568582
119righting reflex (GO:0060013)2.98026550
120C4-dicarboxylate transport (GO:0015740)2.94793042
121axonal fasciculation (GO:0007413)2.94594405
122negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.93871619
123dendrite morphogenesis (GO:0048813)2.92701401
124L-glutamate transport (GO:0015813)2.92614366
125regulation of synaptic transmission, GABAergic (GO:0032228)2.91320436
126vesicle transport along microtubule (GO:0047496)2.90599596
127startle response (GO:0001964)2.90259607
128presynaptic membrane organization (GO:0097090)2.89678227
129glycosphingolipid biosynthetic process (GO:0006688)2.89626875
130social behavior (GO:0035176)2.89515976
131intraspecies interaction between organisms (GO:0051703)2.89515976
132regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88145091
133positive regulation of urine volume (GO:0035810)2.86293147
134regulation of protein kinase A signaling (GO:0010738)2.81845338
135central nervous system projection neuron axonogenesis (GO:0021952)2.81038583
136neuron projection extension (GO:1990138)2.72645313
137positive regulation of cellular response to insulin stimulus (GO:1900078)2.72010641
138mechanosensory behavior (GO:0007638)2.71632439
139dopamine receptor signaling pathway (GO:0007212)2.70737144
140positive regulation of insulin receptor signaling pathway (GO:0046628)2.69313832
141membrane assembly (GO:0071709)2.68094947
142lipid storage (GO:0019915)2.66014045
143negative regulation of response to food (GO:0032096)2.64515127
144negative regulation of appetite (GO:0032099)2.64515127
145fatty acid homeostasis (GO:0055089)2.63461169
146adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.61196767
147triglyceride biosynthetic process (GO:0019432)2.61049647
148presynaptic membrane assembly (GO:0097105)2.60676495
149regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.59702242
150clathrin coat assembly (GO:0048268)2.59476758
151CDP-diacylglycerol biosynthetic process (GO:0016024)2.59364170
152nephron tubule development (GO:0072080)2.59025497
153histone arginine methylation (GO:0034969)2.58949447
154regulation of female receptivity (GO:0045924)2.57581882
155dendritic spine organization (GO:0097061)2.54363167
156regulation of respiratory system process (GO:0044065)2.53957756
157response to monoamine (GO:0071867)2.51602931
158response to catecholamine (GO:0071869)2.51602931

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.08549995
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.47541656
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.31769087
4GBX2_23144817_ChIP-Seq_PC3_Human3.27571620
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13938400
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.93596227
7REST_21632747_ChIP-Seq_MESCs_Mouse2.92913961
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.85064575
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.85064575
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.65170825
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.62640256
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60437917
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.57607551
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57309555
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55504816
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.54425309
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54392587
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.51353220
19DROSHA_22980978_ChIP-Seq_HELA_Human2.50206936
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.40644486
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.38728924
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.33441638
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.32812401
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.32215065
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26228256
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25168692
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.13761874
28RARB_27405468_Chip-Seq_BRAIN_Mouse2.12136596
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.09706958
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90028515
31TAF15_26573619_Chip-Seq_HEK293_Human1.86587789
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.76528550
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.74029049
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69656383
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.69652588
36* SMAD4_21799915_ChIP-Seq_A2780_Human1.67708752
37ZNF274_21170338_ChIP-Seq_K562_Hela1.64962188
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63707516
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51707687
40AR_21572438_ChIP-Seq_LNCaP_Human1.51333619
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49802028
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47600563
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43175619
44RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.41596092
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38534988
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38518080
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.38266058
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35949381
49TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33188873
50OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.32967576
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.32650167
52EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29795618
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.29383184
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.29120531
55* AR_19668381_ChIP-Seq_PC3_Human1.25192151
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24996874
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24355931
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23531862
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.23244186
60TP53_20018659_ChIP-ChIP_R1E_Mouse1.22943207
61P300_19829295_ChIP-Seq_ESCs_Human1.22815332
62RNF2_27304074_Chip-Seq_NSC_Mouse1.17293760
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.17113881
64AR_25329375_ChIP-Seq_VCAP_Human1.16063039
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15741051
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.14801369
67STAT3_23295773_ChIP-Seq_U87_Human1.14646107
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13810740
69SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13526194
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10515849
71MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10504955
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09196180
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08713730
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08348338
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07965925
76KDM2B_26808549_Chip-Seq_K562_Human1.06920448
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06811434
78CTCF_27219007_Chip-Seq_Bcells_Human1.06449835
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.04938126
80CLOCK_20551151_ChIP-Seq_293T_Human1.03447797
81CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02534307
82* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02240487
83TCF4_23295773_ChIP-Seq_U87_Human1.02150516
84SMAD3_21741376_ChIP-Seq_ESCs_Human0.99757332
85CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99589403
86CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98864977
87RING1B_27294783_Chip-Seq_NPCs_Mouse0.98272668
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96683401
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95775815
90YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95342525
91WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95030196
92RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94257514
93* RUNX2_22187159_ChIP-Seq_PCA_Human0.93852963
94ARNT_22903824_ChIP-Seq_MCF-7_Human0.93479513
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93312885
96P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93150387
97* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92342130
98PIAS1_25552417_ChIP-Seq_VCAP_Human0.92273108
99AHR_22903824_ChIP-Seq_MCF-7_Human0.92202623
100TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91789296
101IGF1R_20145208_ChIP-Seq_DFB_Human0.91591700
102FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90812090
103NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90178183
104POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88987139
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88718300
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88718300
107TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88034160
108ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87348131
109GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86745770
110TET1_21490601_ChIP-Seq_MESCs_Mouse0.85502837
111ELK4_26923725_Chip-Seq_MESODERM_Mouse0.84966282
112SMC4_20622854_ChIP-Seq_HELA_Human0.84827376
113ER_23166858_ChIP-Seq_MCF-7_Human0.84819742
114CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84364757
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.83214920
116TP53_23651856_ChIP-Seq_MEFs_Mouse0.82801176
117NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.82344885
118CDX2_19796622_ChIP-Seq_MESCs_Mouse0.81688999
119POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.81615912
120TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81590839
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81473018
122CJUN_26792858_Chip-Seq_BT549_Human0.79520911
123ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.79437362
124CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.79263732
125RAD21_21589869_ChIP-Seq_MESCs_Mouse0.79029723
126SMAD4_21741376_ChIP-Seq_EPCs_Human0.78788007
127SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.77629874
128ZNF217_24962896_ChIP-Seq_MCF-7_Human0.76975740
129SOX9_26525672_Chip-Seq_HEART_Mouse0.76831536
130WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.76700848
131NFIB_24661679_ChIP-Seq_LUNG_Mouse0.76012559
132PRDM14_20953172_ChIP-Seq_ESCs_Human0.74928943

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.17330874
2MP0009046_muscle_twitch4.28443707
3MP0003880_abnormal_central_pattern3.99372709
4MP0005670_abnormal_white_adipose3.93316013
5* MP0003635_abnormal_synaptic_transmissio3.91813358
6MP0002064_seizures3.28881541
7MP0009745_abnormal_behavioral_response3.28005902
8MP0005423_abnormal_somatic_nervous3.12656901
9* MP0002272_abnormal_nervous_system2.92633825
10MP0002063_abnormal_learning/memory/cond2.90855973
11MP0004270_analgesia2.83409433
12MP0001968_abnormal_touch/_nociception2.82790329
13MP0004130_abnormal_muscle_cell2.82542385
14MP0002572_abnormal_emotion/affect_behav2.65067644
15MP0002734_abnormal_mechanical_nocicepti2.59218228
16MP0005666_abnormal_adipose_tissue2.53946550
17MP0008569_lethality_at_weaning2.48441194
18MP0001486_abnormal_startle_reflex2.44275794
19MP0002876_abnormal_thyroid_physiology2.38305452
20MP0002067_abnormal_sensory_capabilities2.36280723
21MP0001501_abnormal_sleep_pattern2.30299232
22MP0002736_abnormal_nociception_after2.30064739
23MP0002184_abnormal_innervation2.26305228
24MP0002735_abnormal_chemical_nociception2.19995488
25MP0001440_abnormal_grooming_behavior2.15422163
26MP0005375_adipose_tissue_phenotype2.11587317
27MP0002971_abnormal_brown_adipose2.06367550
28MP0003122_maternal_imprinting2.06365117
29MP0006276_abnormal_autonomic_nervous2.04739556
30MP0003787_abnormal_imprinting2.02573333
31MP0002733_abnormal_thermal_nociception1.92869743
32MP0001970_abnormal_pain_threshold1.89800512
33MP0004885_abnormal_endolymph1.89336064
34MP0001984_abnormal_olfaction1.86045099
35MP0005551_abnormal_eye_electrophysiolog1.85729223
36MP0002557_abnormal_social/conspecific_i1.84756820
37MP0004142_abnormal_muscle_tone1.82881162
38MP0005386_behavior/neurological_phenoty1.76975031
39MP0004924_abnormal_behavior1.76975031
40MP0003959_abnormal_lean_body1.74551555
41MP0003011_delayed_dark_adaptation1.71533048
42MP0002822_catalepsy1.70228038
43MP0005645_abnormal_hypothalamus_physiol1.66743960
44MP0004811_abnormal_neuron_physiology1.64108702
45MP0003329_amyloid_beta_deposits1.64068455
46MP0009780_abnormal_chondrocyte_physiolo1.63774848
47MP0000003_abnormal_adipose_tissue1.62634476
48MP0000955_abnormal_spinal_cord1.59007331
49MP0004185_abnormal_adipocyte_glucose1.56974563
50MP0004145_abnormal_muscle_electrophysio1.54960776
51MP0002882_abnormal_neuron_morphology1.54291906
52MP0000778_abnormal_nervous_system1.54159169
53MP0001502_abnormal_circadian_rhythm1.53775424
54* MP0002066_abnormal_motor_capabilities/c1.52327419
55MP0006072_abnormal_retinal_apoptosis1.50176772
56MP0002909_abnormal_adrenal_gland1.47645889
57MP0004742_abnormal_vestibular_system1.47359880
58MP0004858_abnormal_nervous_system1.47141778
59MP0003879_abnormal_hair_cell1.45366660
60MP0002229_neurodegeneration1.42228749
61MP0002638_abnormal_pupillary_reflex1.36843665
62MP0005646_abnormal_pituitary_gland1.36400164
63MP0002970_abnormal_white_adipose1.35551189
64MP0009115_abnormal_fat_cell1.29578930
65MP0005394_taste/olfaction_phenotype1.27326597
66MP0005499_abnormal_olfactory_system1.27326597
67MP0003633_abnormal_nervous_system1.26181627
68MP0005334_abnormal_fat_pad1.26112948
69MP0005448_abnormal_energy_balance1.24002991
70MP0003631_nervous_system_phenotype1.19283212
71MP0003632_abnormal_nervous_system1.18709246
72MP0005253_abnormal_eye_physiology1.16746899
73MP0002152_abnormal_brain_morphology1.15500239
74MP0000013_abnormal_adipose_tissue1.13125549
75MP0002752_abnormal_somatic_nervous1.04695903
76MP0003634_abnormal_glial_cell1.00367851
77MP0001529_abnormal_vocalization0.99835500
78MP0004233_abnormal_muscle_weight0.98595584
79MP0001879_abnormal_lymphatic_vessel0.98175508
80MP0008872_abnormal_physiological_respon0.98070803
81MP0005452_abnormal_adipose_tissue0.97711554
82MP0001963_abnormal_hearing_physiology0.97363500
83MP0001905_abnormal_dopamine_level0.96986574
84MP0010329_abnormal_lipoprotein_level0.96928982
85MP0000751_myopathy0.96078984
86MP0002069_abnormal_eating/drinking_beha0.92351510
87MP0003690_abnormal_glial_cell0.91393432
88MP0010368_abnormal_lymphatic_system0.89990024
89MP0006138_congestive_heart_failure0.87746536
90MP0001188_hyperpigmentation0.86705573
91MP0004043_abnormal_pH_regulation0.86582554
92MP0003948_abnormal_gas_homeostasis0.86371584
93MP0005503_abnormal_tendon_morphology0.84859453
94MP0004215_abnormal_myocardial_fiber0.84629565
95MP0001485_abnormal_pinna_reflex0.82665978
96MP0002090_abnormal_vision0.81987069
97MP0004147_increased_porphyrin_level0.81814881
98MP0001299_abnormal_eye_distance/0.81246595
99MP0003646_muscle_fatigue0.80036128
100MP0000920_abnormal_myelination0.79799214
101MP0003121_genomic_imprinting0.79200172
102MP0002089_abnormal_postnatal_growth/wei0.75669634
103MP0002653_abnormal_ependyma_morphology0.75300005
104MP0004085_abnormal_heartbeat0.75179847
105MP0001177_atelectasis0.74787875
106MP0003283_abnormal_digestive_organ0.73767712
107MP0002118_abnormal_lipid_homeostasis0.73549186
108MP0002332_abnormal_exercise_endurance0.73297480
109MP0008877_abnormal_DNA_methylation0.72590339
110MP0003123_paternal_imprinting0.71677859
111MP0004484_altered_response_of0.70380644
112MP0002837_dystrophic_cardiac_calcinosis0.70047811
113MP0008874_decreased_physiological_sensi0.69727473
114MP0005623_abnormal_meninges_morphology0.69239109
115MP0003137_abnormal_impulse_conducting0.67177936
116MP0002078_abnormal_glucose_homeostasis0.66082046
117MP0000604_amyloidosis0.65526289
118MP0005535_abnormal_body_temperature0.65308382
119MP0000750_abnormal_muscle_regeneration0.65091967
120MP0001881_abnormal_mammary_gland0.64823760
121MP0010386_abnormal_urinary_bladder0.64009589
122MP0005275_abnormal_skin_tensile0.63178931
123MP0002108_abnormal_muscle_morphology0.62981271
124MP0003186_abnormal_redox_activity0.62499503
125MP0005195_abnormal_posterior_eye0.60354164
126MP0001943_abnormal_respiration0.60096960
127MP0010769_abnormal_survival0.59229165
128MP0003183_abnormal_peptide_metabolism0.59199771
129MP0010770_preweaning_lethality0.59119858
130MP0000759_abnormal_skeletal_muscle0.57978981
131MP0005257_abnormal_intraocular_pressure0.56908898
132MP0003953_abnormal_hormone_level0.55522197

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.29488309
2Visual hallucinations (HP:0002367)6.00608407
3Progressive cerebellar ataxia (HP:0002073)5.63888512
4Myokymia (HP:0002411)5.46951043
5Atonic seizures (HP:0010819)5.31771867
6Focal seizures (HP:0007359)5.17365010
7Febrile seizures (HP:0002373)4.91960795
8Action tremor (HP:0002345)4.77104736
9Absence seizures (HP:0002121)4.27758856
10Epileptic encephalopathy (HP:0200134)4.17732975
11Gaze-evoked nystagmus (HP:0000640)3.98317878
12Dysdiadochokinesis (HP:0002075)3.80808110
13Acanthosis nigricans (HP:0000956)3.73638823
14Scanning speech (HP:0002168)3.65592720
15Dialeptic seizures (HP:0011146)3.65509187
16Generalized tonic-clonic seizures (HP:0002069)3.65105848
17Neurofibrillary tangles (HP:0002185)3.64600419
18Truncal ataxia (HP:0002078)3.54798819
19Cerebral inclusion bodies (HP:0100314)3.43294939
20Broad-based gait (HP:0002136)3.36574128
21Hemiplegia (HP:0002301)3.28103421
22Abnormal eating behavior (HP:0100738)3.26574776
23Supranuclear gaze palsy (HP:0000605)3.25430577
24Abnormality of the lower motor neuron (HP:0002366)3.17744959
25Dysmetric saccades (HP:0000641)3.17391266
26Genetic anticipation (HP:0003743)3.17236039
27Pheochromocytoma (HP:0002666)3.16561989
28Depression (HP:0000716)3.14497215
29Impaired smooth pursuit (HP:0007772)3.11696996
30Dysmetria (HP:0001310)3.09108611
31Supernumerary nipples (HP:0002558)3.08971409
32Failure to thrive in infancy (HP:0001531)3.04537905
33Abnormality of binocular vision (HP:0011514)3.01051169
34Diplopia (HP:0000651)3.01051169
35Intention tremor (HP:0002080)2.96641649
36Abnormality of ocular smooth pursuit (HP:0000617)2.92610841
37Mutism (HP:0002300)2.90358954
38Anxiety (HP:0000739)2.82785366
39Ankle clonus (HP:0011448)2.80423704
40Neuroendocrine neoplasm (HP:0100634)2.80078967
41Postural instability (HP:0002172)2.79638689
42Ventricular fibrillation (HP:0001663)2.77140721
43Hyperventilation (HP:0002883)2.73100542
44Hemiparesis (HP:0001269)2.70549768
45Poor eye contact (HP:0000817)2.70220300
46Agitation (HP:0000713)2.69411553
47Horizontal nystagmus (HP:0000666)2.68513310
48Status epilepticus (HP:0002133)2.66627096
49Symphalangism affecting the phalanges of the hand (HP:0009773)2.64497139
50Polyphagia (HP:0002591)2.62719110
51Impaired social interactions (HP:0000735)2.62028038
52Abnormal social behavior (HP:0012433)2.62028038
53Hypertriglyceridemia (HP:0002155)2.58748308
54Central scotoma (HP:0000603)2.58699762
55Progressive inability to walk (HP:0002505)2.57702345
56Limb dystonia (HP:0002451)2.56300668
57Impaired vibration sensation in the lower limbs (HP:0002166)2.55900537
58Postural tremor (HP:0002174)2.55031657
59Difficulty running (HP:0009046)2.54385132
60Tetraplegia (HP:0002445)2.51895821
61Long foot (HP:0001833)2.50882823
62Thyroid-stimulating hormone excess (HP:0002925)2.45882650
63Abnormality of the corticospinal tract (HP:0002492)2.45056452
64Back pain (HP:0003418)2.44876090
65Rapidly progressive (HP:0003678)2.43938428
66Abnormality of saccadic eye movements (HP:0000570)2.38447720
67Drooling (HP:0002307)2.37324754
68Excessive salivation (HP:0003781)2.37324754
69Lower limb amyotrophy (HP:0007210)2.35389067
70Abnormality of macular pigmentation (HP:0008002)2.33625254
71Turricephaly (HP:0000262)2.33027830
72Narrow nasal bridge (HP:0000446)2.32773115
73Termporal pattern (HP:0011008)2.32527549
74Insidious onset (HP:0003587)2.32527549
75Urinary bladder sphincter dysfunction (HP:0002839)2.31353304
76Spastic gait (HP:0002064)2.31192557
77Psychosis (HP:0000709)2.30051944
78Abnormal hair whorl (HP:0010721)2.29692691
79Congenital stationary night blindness (HP:0007642)2.27526465
80Insulin resistance (HP:0000855)2.25704833
81Hypoplasia of the brainstem (HP:0002365)2.25261819
82Aplasia/Hypoplasia of the brainstem (HP:0007362)2.25261819
83Broad nasal tip (HP:0000455)2.23865281
84Lower limb muscle weakness (HP:0007340)2.22729820
85Bradykinesia (HP:0002067)2.22060967
86Amyotrophic lateral sclerosis (HP:0007354)2.22004211
87Frequent falls (HP:0002359)2.21044334
88Hyperthyroidism (HP:0000836)2.20725172
89Specific learning disability (HP:0001328)2.15535828
90Gait ataxia (HP:0002066)2.14635033
91Fetal akinesia sequence (HP:0001989)2.11296198
92Distal lower limb amyotrophy (HP:0008944)2.10147762
93Morphological abnormality of the pyramidal tract (HP:0002062)2.09465175
94Neuronal loss in central nervous system (HP:0002529)2.07958843
95Limb ataxia (HP:0002070)2.06858112
96Urinary urgency (HP:0000012)2.06817252
97Neoplasm of the peripheral nervous system (HP:0100007)2.06791617
98Difficulty climbing stairs (HP:0003551)2.05662773
99Hypoventilation (HP:0002791)2.05252415
100Growth hormone excess (HP:0000845)2.04989988
101Abnormality of the labia minora (HP:0012880)2.03926949
102Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.02576781
103Gait imbalance (HP:0002141)2.00487335
104Cerebral hypomyelination (HP:0006808)2.00023377
105Diminished motivation (HP:0000745)1.97060157
106Apathy (HP:0000741)1.97009123
107Generalized hypotonia (HP:0001290)1.96072420
108Esotropia (HP:0000565)1.95929318
109Bony spicule pigmentary retinopathy (HP:0007737)1.94606549
110Insulin-resistant diabetes mellitus (HP:0000831)1.94098883
111Menstrual irregularities (HP:0000858)1.94014199
112Amblyopia (HP:0000646)1.92876839
113Epileptiform EEG discharges (HP:0011182)1.92876423
114Hypercortisolism (HP:0001578)1.92044707
115Poor suck (HP:0002033)1.91946085
116EEG with generalized epileptiform discharges (HP:0011198)1.91410517
117Absent speech (HP:0001344)1.91091414
118Neonatal onset (HP:0003623)1.90364867
119Split foot (HP:0001839)1.89335904
120Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88617552
121Scotoma (HP:0000575)1.88539435
122Shallow orbits (HP:0000586)1.88419119
123Protruding ear (HP:0000411)1.87910084
124Spinal canal stenosis (HP:0003416)1.87665226
125Abnormal rod and cone electroretinograms (HP:0008323)1.87041307
126Hypsarrhythmia (HP:0002521)1.87024546
127Upper limb amyotrophy (HP:0009129)1.86541332
128Distal upper limb amyotrophy (HP:0007149)1.86541332
129Blue irides (HP:0000635)1.86360191
130Delusions (HP:0000746)1.86262053
131Oligomenorrhea (HP:0000876)1.85823350
132Clonus (HP:0002169)1.84360833
133Aplasia involving bones of the extremities (HP:0009825)1.84213983
134Aplasia involving bones of the upper limbs (HP:0009823)1.84213983
135Aplasia of the phalanges of the hand (HP:0009802)1.84213983
136Torticollis (HP:0000473)1.82295054
137Ulnar claw (HP:0001178)1.80930261
138Delayed gross motor development (HP:0002194)1.80208144
139Spastic tetraplegia (HP:0002510)1.80117520
140Rigidity (HP:0002063)1.79582566
141Myotonia (HP:0002486)1.79219625
142Focal dystonia (HP:0004373)1.77035429
143Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.76335336
144Insomnia (HP:0100785)1.74668526
145Abnormality of the hip-girdle musculature (HP:0001445)1.72099335
146Abnormality of the musculature of the pelvis (HP:0001469)1.72099335
147Pachygyria (HP:0001302)1.68570967
148Protrusio acetabuli (HP:0003179)1.68058508
149Hammertoe (HP:0001765)1.67191197
150Shoulder girdle muscle weakness (HP:0003547)1.66100393
151Atrophic scars (HP:0001075)1.65344169
152Craniofacial dystonia (HP:0012179)1.63015534

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.88380319
2MAP3K43.46035209
3TESK12.99355830
4MINK12.98147172
5MAP2K72.96529441
6CASK2.81125253
7MAP3K122.80589285
8MARK12.78098169
9MAP3K92.77802565
10NTRK22.69631844
11MAP2K42.46509393
12EPHB22.31485481
13CAMKK22.23255761
14MAP3K62.17000569
15PAK61.98813325
16CDK191.92764886
17GRK51.89694879
18CAMKK11.89476275
19PLK21.77948828
20EPHA21.76663708
21SIK11.76250675
22STK381.74418554
23WNK11.62381411
24RIPK11.59131704
25PRKCG1.58599645
26DAPK21.55034628
27CAMK1D1.50770758
28MAPK131.42878965
29UHMK11.42553071
30SGK4941.41118790
31SGK2231.41118790
32TRIB31.40188417
33PHKG11.39338790
34PHKG21.39338790
35AKT31.38058574
36PRPF4B1.37862243
37SGK21.31527795
38SIK21.31334988
39PNCK1.30752736
40CDK51.30196509
41ERBB41.30168868
42PINK11.22963946
43DDR21.22338583
44MST1R1.17774330
45SGK31.13791430
46PRKCH1.12934419
47ARAF1.10142331
48ABL21.08508924
49DYRK21.08228160
50DAPK11.06791613
51OXSR11.05464595
52WNK31.04279485
53NTRK11.01874100
54CAMK2G0.97409901
55ALK0.95686053
56LMTK20.95568349
57CAMK2A0.94749866
58TNIK0.94232715
59TYRO30.94002480
60CDK180.93299381
61PTK20.93128578
62MARK20.92769872
63NEK10.92045672
64CAMK2B0.91726185
65CDK150.91590339
66CDK140.90548711
67LIMK10.84868944
68STK110.83843894
69KSR10.82886957
70KSR20.82648744
71DYRK1A0.82522451
72ERBB30.82446961
73CAMK10.82438644
74MAPKAPK50.81776425
75RIPK40.81384284
76CAMK2D0.80135173
77TSSK60.79666482
78CDK11A0.79396020
79ICK0.78024692
80CSNK1G20.77794517
81TNK20.75712099
82SCYL20.74893900
83SIK30.69475722
84MAPK120.67706935
85PDGFRA0.67198904
86CDC42BPA0.65704118
87RET0.65621647
88MET0.64806249
89FES0.64279489
90LATS20.64147645
91TRIM280.63769416
92TESK20.62991316
93PIM20.62881475
94CAMK1G0.61834698
95STK38L0.60341305
96PAK30.60310404
97PRKCE0.59974558
98CAMK40.59444634
99PRKD30.58277340
100PDK10.56683213
101SGK10.55218588
102RPS6KA30.55064268
103ROCK20.53243215
104MAPK40.52858598
105FER0.52686643
106BCR0.51425396
107MUSK0.50945705
108EPHB10.50753897
109PDPK10.50335096
110BRAF0.49684566
111TIE10.49467156
112PRKD20.48726319
113EPHA40.48654039
114GRK10.48628268
115RPS6KA20.47931100
116PRKCZ0.47490205
117MOS0.46789872
118CSNK1G30.46769144
119NME10.45939703
120PRKAA20.45238261
121LATS10.42551796
122PRKCB0.41905454
123MAPK100.41569249
124FYN0.41453937
125MAP4K20.41427164
126PKN10.41318245
127ADRBK10.41192911
128PRKAA10.41106417
129PRKACA0.39740280
130GRK70.39731182
131STK390.39559962
132RPS6KB10.39229666
133CSNK1A1L0.38927135
134MAP3K20.38368271
135IRAK30.35295450
136PRKACG0.32949709

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.36468582
2Synaptic vesicle cycle_Homo sapiens_hsa047213.88175153
3GABAergic synapse_Homo sapiens_hsa047273.13920837
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.86843176
5Glutamatergic synapse_Homo sapiens_hsa047242.71600157
6Circadian entrainment_Homo sapiens_hsa047132.60267572
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.56599662
8Olfactory transduction_Homo sapiens_hsa047402.51548982
9Morphine addiction_Homo sapiens_hsa050322.50622805
10Long-term potentiation_Homo sapiens_hsa047202.44254624
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26024002
12Phototransduction_Homo sapiens_hsa047442.17660570
13Long-term depression_Homo sapiens_hsa047302.15331712
14Taste transduction_Homo sapiens_hsa047422.13461994
15Collecting duct acid secretion_Homo sapiens_hsa049662.07854482
16Dopaminergic synapse_Homo sapiens_hsa047282.05408409
17Amphetamine addiction_Homo sapiens_hsa050312.02370438
18Salivary secretion_Homo sapiens_hsa049701.92560634
19PPAR signaling pathway_Homo sapiens_hsa033201.85822610
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.84951770
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.79960084
22Insulin secretion_Homo sapiens_hsa049111.75490128
23Gastric acid secretion_Homo sapiens_hsa049711.72268846
24Cholinergic synapse_Homo sapiens_hsa047251.71851324
25Glycerolipid metabolism_Homo sapiens_hsa005611.69093527
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64970699
27Serotonergic synapse_Homo sapiens_hsa047261.54989802
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.52241402
29AMPK signaling pathway_Homo sapiens_hsa041521.45679765
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45594828
31Phenylalanine metabolism_Homo sapiens_hsa003601.44928425
32Fatty acid elongation_Homo sapiens_hsa000621.41544006
33Calcium signaling pathway_Homo sapiens_hsa040201.35636035
34Cocaine addiction_Homo sapiens_hsa050301.30230070
35Vibrio cholerae infection_Homo sapiens_hsa051101.28235772
36Oxytocin signaling pathway_Homo sapiens_hsa049211.27353684
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27188437
38Renin secretion_Homo sapiens_hsa049241.25968901
39Pyruvate metabolism_Homo sapiens_hsa006201.21300244
40Gap junction_Homo sapiens_hsa045401.20924843
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15709177
42cAMP signaling pathway_Homo sapiens_hsa040241.12889778
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11233275
44Cardiac muscle contraction_Homo sapiens_hsa042601.09933815
45Type II diabetes mellitus_Homo sapiens_hsa049301.08453414
46GnRH signaling pathway_Homo sapiens_hsa049121.07616609
47beta-Alanine metabolism_Homo sapiens_hsa004101.07426918
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06853597
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03530065
50Vitamin B6 metabolism_Homo sapiens_hsa007501.02722036
51Estrogen signaling pathway_Homo sapiens_hsa049151.02256083
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98904113
53Nitrogen metabolism_Homo sapiens_hsa009100.97216477
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.95311309
55Histidine metabolism_Homo sapiens_hsa003400.94710906
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93936094
57Fatty acid metabolism_Homo sapiens_hsa012120.90266938
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86312877
59Thyroid hormone synthesis_Homo sapiens_hsa049180.84800322
60Oocyte meiosis_Homo sapiens_hsa041140.84677343
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82205941
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82035097
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81785637
64Pancreatic secretion_Homo sapiens_hsa049720.78391492
65Tryptophan metabolism_Homo sapiens_hsa003800.75748233
66Glioma_Homo sapiens_hsa052140.71570006
67Melanogenesis_Homo sapiens_hsa049160.70928050
68Type I diabetes mellitus_Homo sapiens_hsa049400.69690172
69Dilated cardiomyopathy_Homo sapiens_hsa054140.69379761
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.68092727
71ErbB signaling pathway_Homo sapiens_hsa040120.65768032
72Tyrosine metabolism_Homo sapiens_hsa003500.65365714
73Axon guidance_Homo sapiens_hsa043600.65323406
74Butanoate metabolism_Homo sapiens_hsa006500.63767318
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.63280033
76Bile secretion_Homo sapiens_hsa049760.62542001
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61807842
78Fat digestion and absorption_Homo sapiens_hsa049750.61039814
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58920337
80ECM-receptor interaction_Homo sapiens_hsa045120.58646235
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57872663
82Inositol phosphate metabolism_Homo sapiens_hsa005620.56923173
83MAPK signaling pathway_Homo sapiens_hsa040100.56702688
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.56345907
85Alcoholism_Homo sapiens_hsa050340.56070362
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50738109
87Oxidative phosphorylation_Homo sapiens_hsa001900.49675362
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49441711
89Tight junction_Homo sapiens_hsa045300.49241715
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48753272
91Renal cell carcinoma_Homo sapiens_hsa052110.47213621
92Alzheimers disease_Homo sapiens_hsa050100.46586332
93Glucagon signaling pathway_Homo sapiens_hsa049220.45328742
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43419647
95Focal adhesion_Homo sapiens_hsa045100.43227407
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.43178653
97Arginine biosynthesis_Homo sapiens_hsa002200.42778172
98mTOR signaling pathway_Homo sapiens_hsa041500.42565596
99Choline metabolism in cancer_Homo sapiens_hsa052310.42456098
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41922042
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41757830
102Fatty acid degradation_Homo sapiens_hsa000710.40417658
103Hippo signaling pathway_Homo sapiens_hsa043900.40276511
104Prion diseases_Homo sapiens_hsa050200.39424947
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38945108
106Dorso-ventral axis formation_Homo sapiens_hsa043200.38847715
107Ovarian steroidogenesis_Homo sapiens_hsa049130.38400482
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38338920
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37793867
110Endocytosis_Homo sapiens_hsa041440.37595080
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37560627
112Ras signaling pathway_Homo sapiens_hsa040140.37526569
113Phagosome_Homo sapiens_hsa041450.36780392
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.36556888
115Steroid biosynthesis_Homo sapiens_hsa001000.36345687
116Rheumatoid arthritis_Homo sapiens_hsa053230.36309572
117Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35257686
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31693881
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31661241
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31521100
121Insulin signaling pathway_Homo sapiens_hsa049100.29322911
122Rap1 signaling pathway_Homo sapiens_hsa040150.28498520
123Circadian rhythm_Homo sapiens_hsa047100.26993404
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26716010
125Parkinsons disease_Homo sapiens_hsa050120.25653433
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.24945724
127Endometrial cancer_Homo sapiens_hsa052130.24100286
128Fatty acid biosynthesis_Homo sapiens_hsa000610.23668410
129Chemokine signaling pathway_Homo sapiens_hsa040620.23581174

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