CALCB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of Cdc42 GTPase activity (GO:0043089)9.01414038
2regulation of T-helper 1 cell differentiation (GO:0045625)8.57759142
3positive regulation of antigen processing and presentation (GO:0002579)8.02935177
4positive regulation of granulocyte chemotaxis (GO:0071624)6.78872866
5regulation of antigen processing and presentation (GO:0002577)6.72656534
6positive regulation of T-helper 1 type immune response (GO:0002827)6.40905544
7imidazole-containing compound metabolic process (GO:0052803)6.23659291
8positive regulation of glycoprotein biosynthetic process (GO:0010560)6.21377550
9positive regulation of T-helper cell differentiation (GO:0045624)5.93417554
10response to nitric oxide (GO:0071731)5.93314603
11positive regulation of neutrophil chemotaxis (GO:0090023)5.65663201
12positive regulation of neutrophil migration (GO:1902624)5.65663201
13response to prostaglandin E (GO:0034695)5.57107097
14dendritic cell chemotaxis (GO:0002407)5.40842152
15positive regulation of glycoprotein metabolic process (GO:1903020)5.28543572
16synaptic vesicle maturation (GO:0016188)5.15719045
17detection of temperature stimulus involved in sensory perception of pain (GO:0050965)5.11351521
18detection of temperature stimulus involved in sensory perception (GO:0050961)5.11351521
19cellular response to ATP (GO:0071318)4.96001504
20regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)4.92247241
21chromatin remodeling at centromere (GO:0031055)4.91042444
22cellular protein complex localization (GO:0034629)4.72663081
23CENP-A containing nucleosome assembly (GO:0034080)4.70439873
24positive regulation of interleukin-1 beta secretion (GO:0050718)4.66424874
25regulation of Cdc42 GTPase activity (GO:0043088)4.65532609
26response to prostaglandin (GO:0034694)4.63602657
27detection of temperature stimulus (GO:0016048)4.62851344
28regulation of T-helper 1 type immune response (GO:0002825)4.47959775
29negative regulation of interleukin-10 production (GO:0032693)4.36591903
30positive regulation of interleukin-1 secretion (GO:0050716)4.35602291
31positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.34590947
32DNA replication checkpoint (GO:0000076)4.29587582
33dendritic cell differentiation (GO:0097028)4.28317905
34histone exchange (GO:0043486)4.23742578
35regulation of interleukin-1 beta secretion (GO:0050706)4.18029243
36regulation of T-helper cell differentiation (GO:0045622)4.16033024
37positive regulation of interleukin-1 production (GO:0032732)4.14199693
38negative regulation of muscle hypertrophy (GO:0014741)4.12373805
39regulation of neutrophil migration (GO:1902622)4.07863270
40regulation of neutrophil chemotaxis (GO:0090022)4.07863270
41positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)4.07407400
42regulation of granulocyte chemotaxis (GO:0071622)4.02406254
43regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.97264699
44regulation of mitotic spindle checkpoint (GO:1903504)3.97264699
45NIK/NF-kappaB signaling (GO:0038061)3.91366391
46bundle of His cell to Purkinje myocyte communication (GO:0086069)3.86109621
47dendritic cell migration (GO:0036336)3.80892640
48negative regulation of calcium ion transport into cytosol (GO:0010523)3.77374710
49regulation of interleukin-1 secretion (GO:0050704)3.76379469
50positive regulation of interleukin-1 beta production (GO:0032731)3.76239788
51positive regulation of NF-kappaB import into nucleus (GO:0042346)3.75600452
52transcription elongation from RNA polymerase III promoter (GO:0006385)3.69797955
53termination of RNA polymerase III transcription (GO:0006386)3.69797955
54DNA replication-independent nucleosome assembly (GO:0006336)3.66746846
55DNA replication-independent nucleosome organization (GO:0034724)3.66746846
56DNA double-strand break processing (GO:0000729)3.65679134
57oxygen transport (GO:0015671)3.63749016
58striated muscle atrophy (GO:0014891)3.60725569
59regulation of nuclear cell cycle DNA replication (GO:0033262)3.56699394
60exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.53242321
61DNA damage response, detection of DNA damage (GO:0042769)3.51801768
62peripheral nervous system neuron development (GO:0048935)3.48315602
63nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.45130332
64muscle atrophy (GO:0014889)3.44461808
65negative regulation of DNA-dependent DNA replication (GO:2000104)3.41731766
66regulation of activation of Janus kinase activity (GO:0010533)3.41650472
67positive regulation of receptor biosynthetic process (GO:0010870)3.40687378
68establishment of protein localization to mitochondrial membrane (GO:0090151)3.38056559
69proteasome assembly (GO:0043248)3.31801177
70skeletal muscle tissue regeneration (GO:0043403)3.31519310
71leukocyte tethering or rolling (GO:0050901)3.31306126
72maturation of 5.8S rRNA (GO:0000460)3.26570412
73detection of bacterium (GO:0016045)3.25437591
74single strand break repair (GO:0000012)3.24087816
75negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.23571074
76skeletal muscle adaptation (GO:0043501)3.22201091
77somatic hypermutation of immunoglobulin genes (GO:0016446)3.21230480
78somatic diversification of immune receptors via somatic mutation (GO:0002566)3.21230480
79positive regulation of growth hormone secretion (GO:0060124)3.20402114
80respiratory chain complex IV assembly (GO:0008535)3.20261864
81sympathetic nervous system development (GO:0048485)3.20234434
82positive regulation of interleukin-12 production (GO:0032735)3.19143755
83peptidyl-histidine modification (GO:0018202)3.17410224
84regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.14141524
85pseudouridine synthesis (GO:0001522)3.11284425
86myeloid dendritic cell differentiation (GO:0043011)3.11185987
87DNA strand elongation involved in DNA replication (GO:0006271)3.09424785
88chaperone-mediated protein transport (GO:0072321)3.09006694
89sequestering of actin monomers (GO:0042989)3.08737010
90nitric oxide biosynthetic process (GO:0006809)3.08277090
91regulation of lipoprotein particle clearance (GO:0010984)3.07644207
92negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.06484432
93negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.06484432
94negative regulation of mitotic sister chromatid segregation (GO:0033048)3.06484432
95negative regulation of mitotic sister chromatid separation (GO:2000816)3.06484432
96negative regulation of sister chromatid segregation (GO:0033046)3.06484432
97regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.05345747
98regulation of DNA endoreduplication (GO:0032875)3.05179434
99peptide catabolic process (GO:0043171)3.04645673
100negative regulation of chromosome segregation (GO:0051985)3.03677421
101negative regulation of dendrite morphogenesis (GO:0050774)3.02393715
102growth hormone secretion (GO:0030252)3.02250804
103DNA replication-dependent nucleosome organization (GO:0034723)3.01716330
104DNA replication-dependent nucleosome assembly (GO:0006335)3.01716330
105detection of other organism (GO:0098543)3.01345219
106synapsis (GO:0007129)3.00345494
107cytoplasmic mRNA processing body assembly (GO:0033962)2.99680212
108protein neddylation (GO:0045116)2.98849225
109spindle checkpoint (GO:0031577)2.97829626
110regulation of double-strand break repair via homologous recombination (GO:0010569)2.96381468
111glutathione biosynthetic process (GO:0006750)2.93980428
112cytokine secretion (GO:0050663)2.93447296
113regulation of natural killer cell differentiation (GO:0032823)2.91046215
114mitochondrial respiratory chain complex assembly (GO:0033108)2.90371180
115substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.89502243
116substrate-independent telencephalic tangential migration (GO:0021826)2.89502243
117DNA strand elongation (GO:0022616)2.89458164
118response to gravity (GO:0009629)2.88678684
119regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.87969333
120regulation of posttranscriptional gene silencing (GO:0060147)2.86695474
121regulation of gene silencing by miRNA (GO:0060964)2.86695474
122regulation of gene silencing by RNA (GO:0060966)2.86695474
123positive regulation of monocyte chemotaxis (GO:0090026)2.86156128
124telomere maintenance via semi-conservative replication (GO:0032201)2.86066901
125cytochrome complex assembly (GO:0017004)2.85730346
126negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.85725866
127mitotic spindle checkpoint (GO:0071174)2.85447611
128mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.85020601
129hydrogen peroxide catabolic process (GO:0042744)2.84969602
130negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.83951234
131lactate metabolic process (GO:0006089)2.83704201
132protein polyglutamylation (GO:0018095)2.81630322
133negative regulation of heart rate (GO:0010459)2.81249867
134tongue development (GO:0043586)2.81060042
135ventricular trabecula myocardium morphogenesis (GO:0003222)2.80143918
136histone H2A acetylation (GO:0043968)2.80039827
137spindle assembly checkpoint (GO:0071173)2.79896634
138nucleobase biosynthetic process (GO:0046112)2.79885642
139behavioral response to nicotine (GO:0035095)2.78713207
140mitotic spindle assembly checkpoint (GO:0007094)2.78509645
141recombinational repair (GO:0000725)2.78460526
142positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.78123146
143protein K6-linked ubiquitination (GO:0085020)2.78029683
144heterotypic cell-cell adhesion (GO:0034113)2.77854078
145purine nucleobase biosynthetic process (GO:0009113)2.76301253
146double-strand break repair via homologous recombination (GO:0000724)2.75883593
147renal absorption (GO:0070293)2.74921357
148spliceosomal snRNP assembly (GO:0000387)2.74896471
149positive regulation of cholesterol efflux (GO:0010875)2.72132122
150intermediate filament organization (GO:0045109)2.71900576
151L-serine metabolic process (GO:0006563)2.71054371
152regulation of mitotic metaphase/anaphase transition (GO:0030071)2.70533966
153regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.70533966
154response to X-ray (GO:0010165)2.70437046
155regulation of cAMP-dependent protein kinase activity (GO:2000479)2.70411849
156positive regulation of prostaglandin secretion (GO:0032308)2.69825679
157positive regulation of leukocyte migration (GO:0002687)2.69642595
158regulation of interleukin-1 production (GO:0032652)2.69566468
159mitochondrial RNA metabolic process (GO:0000959)2.69543744
160protein complex biogenesis (GO:0070271)2.69253645
161response to ATP (GO:0033198)2.68683388
162protein complex localization (GO:0031503)2.68659745
163regulation of bile acid biosynthetic process (GO:0070857)2.68268701
164kinetochore assembly (GO:0051382)2.67450828
165regulation of sister chromatid segregation (GO:0033045)2.66302443
166regulation of mitotic sister chromatid separation (GO:0010965)2.66302443
167regulation of mitotic sister chromatid segregation (GO:0033047)2.66302443
168protein localization to kinetochore (GO:0034501)2.66266505
169kinetochore organization (GO:0051383)2.66165910
170mitotic recombination (GO:0006312)2.64852648
171regulation of cardioblast proliferation (GO:0003264)2.64720853
172regulation of secondary heart field cardioblast proliferation (GO:0003266)2.64720853
173cullin deneddylation (GO:0010388)2.64298257
174regulation of prostaglandin secretion (GO:0032306)2.64109975
175positive regulation of urine volume (GO:0035810)2.63998767
176regulation of helicase activity (GO:0051095)2.63652654
177replication fork processing (GO:0031297)2.63452774
178acrosome assembly (GO:0001675)2.61987324
179rRNA processing (GO:0006364)2.59392042
180mitotic metaphase plate congression (GO:0007080)2.59134830
181telomere maintenance via recombination (GO:0000722)2.58730243
182mitotic sister chromatid segregation (GO:0000070)2.57160022
183protein-cofactor linkage (GO:0018065)2.56720124
184regulation of mitochondrial translation (GO:0070129)2.55978699
185attachment of spindle microtubules to kinetochore (GO:0008608)2.55661282
186mitotic sister chromatid cohesion (GO:0007064)2.55078110
187enteric nervous system development (GO:0048484)2.53302569
188RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.52300432
189heterochromatin organization (GO:0070828)2.51607039
190rRNA metabolic process (GO:0016072)2.50550253
191mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.50492089
192ATP-dependent chromatin remodeling (GO:0043044)2.50380814
193mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.49146388
194mitochondrial respiratory chain complex I assembly (GO:0032981)2.49146388
195NADH dehydrogenase complex assembly (GO:0010257)2.49146388
196IMP biosynthetic process (GO:0006188)2.49134485
197telomere maintenance via telomerase (GO:0007004)2.48662592
198DNA replication initiation (GO:0006270)2.47099185
199negative regulation of mitosis (GO:0045839)2.46423658
200regulation of dendritic cell antigen processing and presentation (GO:0002604)11.8136818

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.03730884
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.95004929
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.33224112
4VDR_22108803_ChIP-Seq_LS180_Human3.30603971
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.25565265
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.21456352
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.20153401
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.86799830
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.85750249
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.70760265
11ZNF274_21170338_ChIP-Seq_K562_Hela2.65328248
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.55405016
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.41779825
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.35840544
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35284083
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.33884946
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.31947074
18FUS_26573619_Chip-Seq_HEK293_Human2.31896266
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.30767616
20DROSHA_22980978_ChIP-Seq_HELA_Human2.28553763
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.23215869
22JARID2_20064375_ChIP-Seq_MESCs_Mouse2.22946053
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19338101
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.15577220
25ELK1_19687146_ChIP-ChIP_HELA_Human2.14842416
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12439604
27EWS_26573619_Chip-Seq_HEK293_Human2.07568838
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.06612220
29EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02735240
30RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02735240
31FOXM1_23109430_ChIP-Seq_U2OS_Human2.02013980
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.98201145
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.96475294
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.96362237
35* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.96329751
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.93945787
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.90134709
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87926827
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.86145752
40VDR_23849224_ChIP-Seq_CD4+_Human1.85417347
41EZH2_22144423_ChIP-Seq_EOC_Human1.83293879
42MYC_18940864_ChIP-ChIP_HL60_Human1.82466736
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81953704
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.74454002
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72326644
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70090250
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69126877
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69111367
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65669157
50* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63863053
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.62713250
52GBX2_23144817_ChIP-Seq_PC3_Human1.61737982
53FOXP3_21729870_ChIP-Seq_TREG_Human1.61436108
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60058846
55TP63_17297297_ChIP-ChIP_HaCaT_Human1.56925017
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.56567328
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.55399684
58NANOG_16153702_ChIP-ChIP_HESCs_Human1.53787289
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53695352
60EGR1_19032775_ChIP-ChIP_M12_Human1.53694192
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.48683214
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48307046
63SOX2_20726797_ChIP-Seq_SW620_Human1.47415817
64TTF2_22483619_ChIP-Seq_HELA_Human1.47152655
65BCAT_22108803_ChIP-Seq_LS180_Human1.45367661
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.45298281
67RNF2_27304074_Chip-Seq_ESCs_Mouse1.45023463
68HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44528921
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.43819171
70SOX2_16153702_ChIP-ChIP_HESCs_Human1.42524776
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41256925
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40908142
73IGF1R_20145208_ChIP-Seq_DFB_Human1.40837607
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.39895368
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39703742
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38900305
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.38331085
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.37794893
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36924144
80ETV2_25802403_ChIP-Seq_MESCs_Mouse1.36014116
81P300_19829295_ChIP-Seq_ESCs_Human1.35446406
82ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33612916
83TAF15_26573619_Chip-Seq_HEK293_Human1.33580070
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32883896
85GABP_19822575_ChIP-Seq_HepG2_Human1.32872313
86MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32169098
87IRF8_22096565_ChIP-ChIP_GC-B_Human1.31445312
88MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31367328
89AR_25329375_ChIP-Seq_VCAP_Human1.31120837
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29568265
91NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28906384
92NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28522933
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27777727
94DCP1A_22483619_ChIP-Seq_HELA_Human1.26457731
95ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26181774
96PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24302304
97XRN2_22483619_ChIP-Seq_HELA_Human1.23701174
98TCF4_18268006_ChIP-ChIP_LS174T_Human1.23361165
99* REST_21632747_ChIP-Seq_MESCs_Mouse1.22627166
100E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20540610
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19654764
102CBX2_27304074_Chip-Seq_ESCs_Mouse1.19372808
103SRF_21415370_ChIP-Seq_HL-1_Mouse1.18984202
104IRF1_19129219_ChIP-ChIP_H3396_Human1.18964792
105AHR_22903824_ChIP-Seq_MCF-7_Human1.18472051
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17784960
107RNF2_27304074_Chip-Seq_NSC_Mouse1.17599210
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17199124
109TCF4_22108803_ChIP-Seq_LS180_Human1.16782396
110MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15116760
111ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15081305
112SMAD_19615063_ChIP-ChIP_OVARY_Human1.13947748
113TP53_18474530_ChIP-ChIP_U2OS_Human1.13763673
114MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13704481
115SMAD4_21799915_ChIP-Seq_A2780_Human1.13616032
116VDR_24787735_ChIP-Seq_THP-1_Human1.12352223
117CBP_20019798_ChIP-Seq_JUKART_Human1.12206467
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12206467
119NOTCH1_21737748_ChIP-Seq_TLL_Human1.11827144
120KDM2B_26808549_Chip-Seq_REH_Human1.10789306
121CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10484417
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10272630
123NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10272630
124POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09379960
125CDX2_22108803_ChIP-Seq_LS180_Human1.09275741
126NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08965905
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06553904
128PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06412358
129ESR1_21235772_ChIP-Seq_MCF-7_Human1.05794087
130AR_21909140_ChIP-Seq_LNCAP_Human1.04848906
131EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04151490
132CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03395545
133ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01302001
134P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00220456
135CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00024015
136RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99454302
137CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99281427
138YY1_21170310_ChIP-Seq_MESCs_Mouse0.99239749
139POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99049661
140ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99015032
141SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98888097
142ESR1_20079471_ChIP-ChIP_T-47D_Human0.98770190
143TRIM28_21343339_ChIP-Seq_HEK293_Human0.98519052
144NANOG_18555785_Chip-Seq_ESCs_Mouse0.97105866
145ER_23166858_ChIP-Seq_MCF-7_Human0.96589910
146IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96506701
147STAT3_23295773_ChIP-Seq_U87_Human0.96118316
148BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95982281
149FOXO3_23340844_ChIP-Seq_DLD1_Human0.94556584
150HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94480629
151ARNT_22903824_ChIP-Seq_MCF-7_Human0.94308630
152STAT1_17558387_ChIP-Seq_HELA_Human0.93742059
153SMAD3_21741376_ChIP-Seq_EPCs_Human0.93198011
154ERG_20517297_ChIP-Seq_VCAP_Human0.92743699
155FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92629514
156MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92514406
157OCT4_20526341_ChIP-Seq_ESCs_Human0.91765471
158UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91425615
159EZH2_27294783_Chip-Seq_NPCs_Mouse0.90874147
160SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90488700
161FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90061237
162RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89394011
163KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88704936
164CMYC_18555785_Chip-Seq_ESCs_Mouse0.88653437
165SOX2_19829295_ChIP-Seq_ESCs_Human0.88375113
166NANOG_19829295_ChIP-Seq_ESCs_Human0.88375113
167AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87989912
168* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87581991
169SOX2_21211035_ChIP-Seq_LN229_Gbm0.87350280
170FOXA1_25329375_ChIP-Seq_VCAP_Human0.87187667
171FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87187667
172CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86815792
173STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.86054460
174OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85992423
175CJUN_26792858_Chip-Seq_BT549_Human0.85381901
176* CTCF_27219007_Chip-Seq_Bcells_Human0.85259537
177MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85128674
178JUN_21703547_ChIP-Seq_K562_Human0.84682511
179IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.83973395
180KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.83732994
181STAT3_18555785_ChIP-Seq_MESCs_Mouse0.83608367
182NANOG_18555785_ChIP-Seq_MESCs_Mouse0.82910144
183KDM5A_27292631_Chip-Seq_BREAST_Human0.82700956
184DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82603187

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat6.94530986
2MP0002876_abnormal_thyroid_physiology5.95191632
3MP0002735_abnormal_chemical_nociception5.56098464
4MP0000685_abnormal_immune_system4.97336636
5MP0001348_abnormal_lacrimal_gland4.37948691
6MP0005645_abnormal_hypothalamus_physiol3.78752289
7MP0001346_abnormal_lacrimal_gland3.63016571
8MP0003693_abnormal_embryo_hatching3.53032901
9MP0010094_abnormal_chromosome_stability3.35884094
10MP0008058_abnormal_DNA_repair3.34009887
11MP0005647_abnormal_sex_gland3.04944102
12MP0008877_abnormal_DNA_methylation2.98980557
13MP0004510_myositis2.90731689
14MP0001968_abnormal_touch/_nociception2.78891569
15MP0001835_abnormal_antigen_presentation2.77930114
16MP0002736_abnormal_nociception_after2.66616275
17MP0002734_abnormal_mechanical_nocicepti2.66398687
18MP0002160_abnormal_reproductive_system2.59954321
19MP0004270_analgesia2.55833530
20MP0002733_abnormal_thermal_nociception2.54032396
21MP0008932_abnormal_embryonic_tissue2.51758938
22MP0001986_abnormal_taste_sensitivity2.49419088
23MP0001873_stomach_inflammation2.40777966
24MP0003111_abnormal_nucleus_morphology2.38976791
25MP0004957_abnormal_blastocyst_morpholog2.35663875
26MP0006292_abnormal_olfactory_placode2.34620376
27MP0005310_abnormal_salivary_gland2.33641794
28MP0006276_abnormal_autonomic_nervous2.31882447
29MP0008007_abnormal_cellular_replicative2.28066903
30MP0002138_abnormal_hepatobiliary_system2.20442885
31MP0003077_abnormal_cell_cycle2.16715293
32MP0001188_hyperpigmentation2.08869680
33MP0001970_abnormal_pain_threshold2.03859332
34MP0006072_abnormal_retinal_apoptosis1.93850837
35MP0003786_premature_aging1.93415877
36MP0003718_maternal_effect1.92505834
37MP0002102_abnormal_ear_morphology1.91350054
38MP0001293_anophthalmia1.85324887
39MP0006082_CNS_inflammation1.78078969
40MP0003183_abnormal_peptide_metabolism1.72731398
41MP0003879_abnormal_hair_cell1.71183773
42MP0002638_abnormal_pupillary_reflex1.71179130
43MP0003959_abnormal_lean_body1.70549457
44MP0003937_abnormal_limbs/digits/tail_de1.69026033
45MP0004858_abnormal_nervous_system1.65779750
46MP0001529_abnormal_vocalization1.65364484
47MP0003890_abnormal_embryonic-extraembry1.64664183
48MP0003787_abnormal_imprinting1.63979284
49MP0003011_delayed_dark_adaptation1.55644047
50MP0003941_abnormal_skin_development1.54328365
51MP0003121_genomic_imprinting1.48115856
52MP0000631_abnormal_neuroendocrine_gland1.46757307
53MP0002938_white_spotting1.45911944
54MP0000049_abnormal_middle_ear1.44947859
55MP0005671_abnormal_response_to1.42756927
56MP0005499_abnormal_olfactory_system1.38068914
57MP0005394_taste/olfaction_phenotype1.38068914
58MP0006035_abnormal_mitochondrial_morpho1.35853160
59MP0005253_abnormal_eye_physiology1.34617615
60MP0002148_abnormal_hypersensitivity_rea1.33327559
61MP0001501_abnormal_sleep_pattern1.32078131
62MP0005551_abnormal_eye_electrophysiolog1.31979902
63MP0003136_yellow_coat_color1.27532054
64MP0002877_abnormal_melanocyte_morpholog1.25280674
65MP0001984_abnormal_olfaction1.24316619
66MP0001145_abnormal_male_reproductive1.20626418
67MP0008789_abnormal_olfactory_epithelium1.18886632
68MP0002277_abnormal_respiratory_mucosa1.18829604
69MP0003567_abnormal_fetal_cardiomyocyte1.15995109
70MP0002210_abnormal_sex_determination1.15982512
71MP0001730_embryonic_growth_arrest1.15563716
72MP0002697_abnormal_eye_size1.15324735
73MP0000653_abnormal_sex_gland1.15304609
74MP0001286_abnormal_eye_development1.14244982
75MP0005389_reproductive_system_phenotype1.14064406
76MP0001929_abnormal_gametogenesis1.12785374
77MP0003119_abnormal_digestive_system1.12181401
78MP0003646_muscle_fatigue1.11847100
79MP0001177_atelectasis1.11268414
80MP0004782_abnormal_surfactant_physiolog1.10407083
81MP0002234_abnormal_pharynx_morphology1.10158333
82MP0003122_maternal_imprinting1.09022822
83MP0004133_heterotaxia1.08403651
84MP0006036_abnormal_mitochondrial_physio1.07848742
85MP0009333_abnormal_splenocyte_physiolog1.07325152
86MP0002090_abnormal_vision1.06958555
87MP0001542_abnormal_bone_strength1.06359628
88MP0009745_abnormal_behavioral_response1.04575214
89MP0002272_abnormal_nervous_system1.03938784
90MP0002184_abnormal_innervation1.02975280
91MP0002084_abnormal_developmental_patter1.02796488
92MP0003698_abnormal_male_reproductive1.02368594
93MP0002085_abnormal_embryonic_tissue1.01618011
94MP0005391_vision/eye_phenotype0.98938320
95MP0010386_abnormal_urinary_bladder0.98750305
96MP0003123_paternal_imprinting0.97420793
97MP0010352_gastrointestinal_tract_polyps0.97407562
98MP0000470_abnormal_stomach_morphology0.95720285
99MP0002796_impaired_skin_barrier0.95718836
100MP0002405_respiratory_system_inflammati0.94585809
101MP0003638_abnormal_response/metabolism_0.93739254
102MP0002282_abnormal_trachea_morphology0.93133942
103MP0002233_abnormal_nose_morphology0.92524683
104MP0005187_abnormal_penis_morphology0.92096922
105MP0001919_abnormal_reproductive_system0.88934147
106MP0001486_abnormal_startle_reflex0.88264772
107MP0008874_decreased_physiological_sensi0.87667663
108MP0003137_abnormal_impulse_conducting0.85813790
109MP0002751_abnormal_autonomic_nervous0.85479771
110MP0003880_abnormal_central_pattern0.84925287
111MP0008057_abnormal_DNA_replication0.84576697
112MP0003045_fibrosis0.84172163
113MP0000350_abnormal_cell_proliferation0.83854023
114MP0009046_muscle_twitch0.81666284
115MP0001764_abnormal_homeostasis0.81634938
116MP0003755_abnormal_palate_morphology0.81585536
117MP0003186_abnormal_redox_activity0.81415756
118MP0002752_abnormal_somatic_nervous0.80814850
119MP0000516_abnormal_urinary_system0.80804975
120MP0005367_renal/urinary_system_phenotyp0.80804975
121MP0001853_heart_inflammation0.80071457
122MP0001697_abnormal_embryo_size0.79625297
123MP0009785_altered_susceptibility_to0.79412955
124MP0000538_abnormal_urinary_bladder0.79380183
125MP0002837_dystrophic_cardiac_calcinosis0.79167815
126MP0003861_abnormal_nervous_system0.78922946
127MP0004215_abnormal_myocardial_fiber0.78331460
128MP0005084_abnormal_gallbladder_morpholo0.78288627
129MP0004859_abnormal_synaptic_plasticity0.77993891
130MP0009672_abnormal_birth_weight0.77871728
131MP0001324_abnormal_eye_pigmentation0.77333636
132MP0001485_abnormal_pinna_reflex0.76350042
133MP0002111_abnormal_tail_morphology0.74344604
134MP0005000_abnormal_immune_tolerance0.74171046
135MP0000778_abnormal_nervous_system0.74120804
136MP0005503_abnormal_tendon_morphology0.74021950
137MP0003453_abnormal_keratinocyte_physiol0.72882526
138MP0001299_abnormal_eye_distance/0.72863776
139MP0003938_abnormal_ear_development0.72371997
140MP0000427_abnormal_hair_cycle0.71398361
141MP0005025_abnormal_response_to0.71211072
142MP0003868_abnormal_feces_composition0.70448081
143MP0000613_abnormal_salivary_gland0.69321058
144MP0002161_abnormal_fertility/fecundity0.69296868
145MP0001790_abnormal_immune_system0.69244494
146MP0005387_immune_system_phenotype0.69244494
147MP0001672_abnormal_embryogenesis/_devel0.69221025
148MP0005380_embryogenesis_phenotype0.69221025
149MP0009765_abnormal_xenobiotic_induced0.68384072
150MP0003300_gastrointestinal_ulcer0.68278122
151MP0000372_irregular_coat_pigmentation0.68106348
152MP0001881_abnormal_mammary_gland0.67417057
153MP0002971_abnormal_brown_adipose0.67407559
154MP0009764_decreased_sensitivity_to0.66305062
155MP0005334_abnormal_fat_pad0.66090558
156MP0002928_abnormal_bile_duct0.65845360
157MP0001800_abnormal_humoral_immune0.65172053
158MP0009115_abnormal_fat_cell0.62489950
159MP0005448_abnormal_energy_balance0.62461693
160MP0000003_abnormal_adipose_tissue0.61443967
161MP0003763_abnormal_thymus_physiology0.58859755
162MP0001756_abnormal_urination0.58626788
163MP0001845_abnormal_inflammatory_respons0.58520020
164MP0000579_abnormal_nail_morphology0.58167988
165MP0008872_abnormal_physiological_respon0.58155064
166MP0002069_abnormal_eating/drinking_beha0.57979465
167MP0003195_calcinosis0.57679453
168MP0010771_integument_phenotype0.56135837
169MP0002089_abnormal_postnatal_growth/wei0.55056668
170MP0003828_pulmonary_edema0.52906243
171MP0005275_abnormal_skin_tensile0.50805655
172MP0005464_abnormal_platelet_physiology0.50393394
173MP0002693_abnormal_pancreas_physiology0.48089469
174MP0002970_abnormal_white_adipose0.47150160
175MP0002108_abnormal_muscle_morphology0.46961631
176MP0001663_abnormal_digestive_system0.46887230
177MP0009643_abnormal_urine_homeostasis0.45627292
178MP0002723_abnormal_immune_serum0.45272738
179MP0002067_abnormal_sensory_capabilities0.45073272
180MP0001440_abnormal_grooming_behavior0.44750345
181MP0003635_abnormal_synaptic_transmissio0.43697384
182MP0005423_abnormal_somatic_nervous0.43185135
183MP0005197_abnormal_uvea_morphology0.40836279
184MP0002557_abnormal_social/conspecific_i0.40814857

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.47863414
2Recurrent cutaneous fungal infections (HP:0011370)5.38457324
3Chronic mucocutaneous candidiasis (HP:0002728)5.38457324
4Hypercortisolism (HP:0001578)5.19381046
5Increased IgE level (HP:0003212)4.97853505
6Congenital malformation of the right heart (HP:0011723)4.72891103
7Double outlet right ventricle (HP:0001719)4.72891103
8Type I diabetes mellitus (HP:0100651)4.69853016
9Keratoconjunctivitis (HP:0001096)4.66276521
10Tongue fasciculations (HP:0001308)4.62828371
11Abnormality of proline metabolism (HP:0010907)4.40367660
12Hydroxyprolinuria (HP:0003080)4.40367660
13Muscle fibrillation (HP:0010546)4.37417505
14Abnormality of calcium-phosphate metabolism (HP:0100530)3.97759741
15Aplasia/Hypoplasia of the spleen (HP:0010451)3.96650461
16Upper limb muscle weakness (HP:0003484)3.91215057
17Xerostomia (HP:0000217)3.85820875
18Birth length less than 3rd percentile (HP:0003561)3.67268296
19Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.50522414
20Recurrent skin infections (HP:0001581)3.43905385
21Recurrent fungal infections (HP:0002841)3.40247915
22Chromsome breakage (HP:0040012)3.37997730
23Asplenia (HP:0001746)3.37839902
24Chromosomal breakage induced by crosslinking agents (HP:0003221)3.32768339
25Myokymia (HP:0002411)3.24217210
26Tetraparesis (HP:0002273)3.22488330
27Abnormality of the labia minora (HP:0012880)3.21087332
28Abnormal pupillary function (HP:0007686)3.15198223
29Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.10724500
30Symphalangism affecting the phalanges of the hand (HP:0009773)3.07798025
31Ulnar claw (HP:0001178)3.00771224
32Truncus arteriosus (HP:0001660)2.98271415
33Acute necrotizing encephalopathy (HP:0006965)2.97733652
34Pendular nystagmus (HP:0012043)2.95259908
35Palmoplantar hyperkeratosis (HP:0000972)2.95005808
36Vertebral compression fractures (HP:0002953)2.93233389
37Meckel diverticulum (HP:0002245)2.92790369
38Plantar hyperkeratosis (HP:0007556)2.92726500
39Right ventricular cardiomyopathy (HP:0011663)2.89095450
40Recurrent gram-negative bacterial infections (HP:0005420)2.88540488
41Type 2 muscle fiber atrophy (HP:0003554)2.86498335
42Aplasia/Hypoplasia of the uvula (HP:0010293)2.86072855
43Abnormality of the phalanges of the 5th finger (HP:0004213)2.83135200
44Prolonged neonatal jaundice (HP:0006579)2.81657170
45Pheochromocytoma (HP:0002666)2.79773507
46Abnormality of glutamine family amino acid metabolism (HP:0010902)2.76921452
47Recurrent bacterial skin infections (HP:0005406)2.74161530
48Abnormality of chromosome stability (HP:0003220)2.72823905
49Abnormality of the ileum (HP:0001549)2.72819398
50Pancreatic fibrosis (HP:0100732)2.70929014
51True hermaphroditism (HP:0010459)2.69286590
52Amniotic constriction ring (HP:0009775)2.68585985
53Abnormality of placental membranes (HP:0011409)2.68585985
54Palmar hyperkeratosis (HP:0010765)2.66202129
55Hypothermia (HP:0002045)2.64917418
56Gingivitis (HP:0000230)2.64056149
57Abnormality of the gastric mucosa (HP:0004295)2.63298234
58Neuroendocrine neoplasm (HP:0100634)2.63003804
59Interstitial pulmonary disease (HP:0006530)2.62671439
60Abnormality of the neuromuscular junction (HP:0003398)2.62526644
61Fatigable weakness (HP:0003473)2.62526644
62Lip pit (HP:0100267)2.59615925
63Sclerocornea (HP:0000647)2.58235388
64Muscle fiber atrophy (HP:0100295)2.58077032
65Occipital encephalocele (HP:0002085)2.57117404
66Acute encephalopathy (HP:0006846)2.57044630
67Abnormal mitochondria in muscle tissue (HP:0008316)2.55971717
68Increased CSF lactate (HP:0002490)2.55111919
69Hypergammaglobulinemia (HP:0010702)2.54078423
70Molar tooth sign on MRI (HP:0002419)2.53824275
71Abnormality of midbrain morphology (HP:0002418)2.53824275
72Abnormality of the preputium (HP:0100587)2.52424870
73Cholelithiasis (HP:0001081)2.51699760
74Mitochondrial inheritance (HP:0001427)2.49760101
75Onion bulb formation (HP:0003383)2.49527716
76Progressive macrocephaly (HP:0004481)2.48909427
77Confusion (HP:0001289)2.46235588
78Recurrent abscess formation (HP:0002722)2.44965741
79Pancreatic cysts (HP:0001737)2.44835458
80Potter facies (HP:0002009)2.43848720
81Facial shape deformation (HP:0011334)2.43848720
82Ectopic kidney (HP:0000086)2.43726801
83Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.40410232
84Abnormal gallbladder morphology (HP:0012437)2.39889675
85Urticaria (HP:0001025)2.35248184
86Hyperglycemia (HP:0003074)2.35144880
87Increased hepatocellular lipid droplets (HP:0006565)2.34273952
88Adrenal overactivity (HP:0002717)2.32376822
89Palpitations (HP:0001962)2.31368880
90Colon cancer (HP:0003003)2.30804804
91Abnormality of the parathyroid morphology (HP:0011766)2.29790464
92Genetic anticipation (HP:0003743)2.29047923
93Hepatocellular necrosis (HP:0001404)2.28854434
94Insidious onset (HP:0003587)2.28094410
95Termporal pattern (HP:0011008)2.28094410
96Absent thumb (HP:0009777)2.26026818
97Keratitis (HP:0000491)2.23956867
98Hypokinesia (HP:0002375)2.22577380
99Abnormality of macrophages (HP:0004311)2.22423679
100Respiratory distress (HP:0002098)2.21725469
101Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19877181
102Abnormality of alanine metabolism (HP:0010916)2.19877181
103Hyperalaninemia (HP:0003348)2.19877181
104Bilateral microphthalmos (HP:0007633)2.19015290
105Nephronophthisis (HP:0000090)2.18629590
106Small intestinal stenosis (HP:0012848)2.18379796
107Duodenal stenosis (HP:0100867)2.18379796
108Abolished electroretinogram (ERG) (HP:0000550)2.17423713
109Lipid accumulation in hepatocytes (HP:0006561)2.16723602
110Volvulus (HP:0002580)2.16573889
111Abnormal lung lobation (HP:0002101)2.15884983
112Reticulocytosis (HP:0001923)2.14687624
113Septo-optic dysplasia (HP:0100842)2.13032064
114Dialeptic seizures (HP:0011146)2.12747129
115Triphalangeal thumb (HP:0001199)2.12404953
116Sloping forehead (HP:0000340)2.09685078
117Hypoplasia of dental enamel (HP:0006297)2.09436584
118Fragile skin (HP:0001030)2.09061608
119Anencephaly (HP:0002323)2.08063821
120Agammaglobulinemia (HP:0004432)2.07642526
121Abnormality of the duodenum (HP:0002246)2.06516376
122Poikilocytosis (HP:0004447)2.06482053
123Abnormal number of incisors (HP:0011064)2.05432772
124Hepatic necrosis (HP:0002605)2.05286164
125Male pseudohermaphroditism (HP:0000037)2.05156883
126Abnormal connection of the cardiac segments (HP:0011545)2.04674213
127Abnormal ventriculo-arterial connection (HP:0011563)2.04674213
128Transposition of the great arteries (HP:0001669)2.04674213
129Supernumerary nipples (HP:0002558)2.03875755
130Fasciculations (HP:0002380)2.03487013
131Abnormality of the vocal cords (HP:0008777)2.02048902
132Esophageal atresia (HP:0002032)2.01977492
133Reticulocytopenia (HP:0001896)2.00344047
134Progressive cerebellar ataxia (HP:0002073)2.00255625
135Sepsis (HP:0100806)1.99505552
136Patellar aplasia (HP:0006443)1.99138049
137Focal seizures (HP:0007359)1.96071567
138Aplasia/Hypoplasia of the patella (HP:0006498)1.95409206
139Abnormality of pain sensation (HP:0010832)1.95093512
140Impaired pain sensation (HP:0007328)1.95093512
141Pustule (HP:0200039)1.94983547
142Milia (HP:0001056)1.94510283
143Erythema (HP:0010783)1.93695901
144Short 5th finger (HP:0009237)1.92714875
145Postnatal microcephaly (HP:0005484)1.92665304
146Myositis (HP:0100614)1.92433030
147Absent radius (HP:0003974)1.92245970
148Multiple enchondromatosis (HP:0005701)1.92214272
149Gastrointestinal atresia (HP:0002589)1.91819658
150Atonic seizures (HP:0010819)1.91813930
151Scrotal hypoplasia (HP:0000046)1.90207624
152Horseshoe kidney (HP:0000085)1.87668481
153Autoamputation (HP:0001218)1.86321004
154Preaxial hand polydactyly (HP:0001177)1.85909643
155Methylmalonic acidemia (HP:0002912)1.85544879
156Obstructive lung disease (HP:0006536)1.85297664
157Chronic obstructive pulmonary disease (HP:0006510)1.85297664
158Segmental peripheral demyelination/remyelination (HP:0003481)1.84794255
1593-Methylglutaconic aciduria (HP:0003535)1.84362365
160Cerebral edema (HP:0002181)1.84094091
161Hematochezia (HP:0002573)1.83485466
162Absent forearm bone (HP:0003953)1.83162051
163Aplasia involving forearm bones (HP:0009822)1.83162051
164Onycholysis (HP:0001806)1.81784073
165Premature loss of primary teeth (HP:0006323)1.81396614
166Aplasia/Hypoplasia of the tibia (HP:0005772)1.79622569
167Abnormal biliary tract physiology (HP:0012439)1.79248704
168Bile duct proliferation (HP:0001408)1.79248704
169Abnormal auditory evoked potentials (HP:0006958)1.78832813
170Genital tract atresia (HP:0001827)1.78595241
171Action tremor (HP:0002345)1.78429227
172Recurrent pneumonia (HP:0006532)1.78189387
173Absence seizures (HP:0002121)1.78017450
174Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77949602
175Increased serum lactate (HP:0002151)1.75561795
176Abnormality of methionine metabolism (HP:0010901)1.75518892
177Microretrognathia (HP:0000308)1.73912908
178Abnormality of serum amino acid levels (HP:0003112)1.72538370
179Oculomotor apraxia (HP:0000657)1.72414354
180Aplastic anemia (HP:0001915)1.72392281
181Clubbing of toes (HP:0100760)1.70524529
182Vaginal atresia (HP:0000148)1.70261667
183Renal Fanconi syndrome (HP:0001994)1.69740162
184Gaze-evoked nystagmus (HP:0000640)1.69276755
185Short tibia (HP:0005736)1.69040996
186Myelodysplasia (HP:0002863)1.67692386
187Abnormality of the carotid arteries (HP:0005344)1.67482550
188Anal atresia (HP:0002023)1.67261108
189Progressive inability to walk (HP:0002505)1.67128638
190Optic nerve hypoplasia (HP:0000609)1.66679542
191Medial flaring of the eyebrow (HP:0010747)1.65217405
192Poor suck (HP:0002033)1.65211992
193Chorioretinal coloboma (HP:0000567)1.64525781
194Small hand (HP:0200055)1.64476568
195Dandy-Walker malformation (HP:0001305)1.64080433
196Hyperglycinemia (HP:0002154)1.62436574
197Bifid tongue (HP:0010297)1.61205904
198Hypoplasia of the pons (HP:0012110)1.60864913
199Aganglionic megacolon (HP:0002251)1.60513517

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.72333850
2WNK34.09324583
3NTRK13.45003875
4EPHA33.42336389
5IRAK43.18747789
6CDC73.18069959
7DYRK1B3.08364659
8BUB13.07605764
9DYRK32.95369325
10ACVR1B2.92909880
11CDK192.71493111
12TTK2.67903705
13BMPR22.64939832
14SIK32.58926801
15PLK42.58677085
16GRK52.57737285
17MKNK22.41846528
18BCR2.40638114
19BRSK22.39400302
20NUAK12.37440154
21ZAK2.32422209
22PNCK2.29831675
23VRK22.23853279
24PLK32.16549588
25ERBB32.07763074
26TRIM282.07352804
27RPS6KA42.07004921
28MINK12.05126234
29SRPK11.94589951
30EIF2AK11.92626046
31PIM21.91404530
32NEK91.88277296
33SCYL21.86324515
34MKNK11.85783121
35KSR21.83196627
36WEE11.82204895
37NLK1.78808039
38EPHB11.76197873
39ARAF1.75292449
40OXSR11.74523787
41LIMK11.74485161
42MST41.73888359
43FRK1.72883928
44GRK11.72023521
45PBK1.71400034
46MAP3K121.69539493
47PINK11.69053136
48INSRR1.66858424
49STK161.65870418
50VRK11.60686565
51DAPK21.56383357
52PRKCI1.51919959
53PLK11.50356143
54MATK1.47529920
55BMPR1B1.41727116
56NME11.40741332
57RIPK41.37206490
58BRSK11.33519233
59NEK11.28191139
60CHEK21.27036915
61PLK21.25906012
62CASK1.25894959
63CSNK1G11.24064820
64SYK1.21412655
65FGFR41.21322389
66CSNK1G21.16037001
67LMTK21.15888455
68FER1.14976059
69IRAK31.12942973
70CSNK1G31.11948104
71MARK31.03336360
72LRRK21.03284738
73TAF11.01241693
74ATR1.01229524
75PRKD31.00768212
76JAK30.99714354
77CSNK1A1L0.93296141
78ADRBK20.91247578
79MAP3K20.90450468
80MAP2K20.90078567
81FGFR30.86175839
82PRKCQ0.83562404
83RPS6KA50.83556220
84MAP4K20.82560917
85RAF10.82015181
86STK240.81205465
87LATS20.80796103
88PRKCE0.79941708
89ATM0.79665240
90TBK10.79107579
91CHEK10.78488895
92JAK20.78325949
93TYK20.78119367
94PRKCD0.77836166
95CHUK0.76740900
96CDC42BPA0.76495599
97IRAK10.76332177
98MAP2K10.74420144
99TNK20.74376948
100RET0.73826863
101IKBKE0.73292480
102NTRK30.73167873
103TLK10.71766466
104TESK10.69381331
105DYRK1A0.68060295
106PAK60.67767976
107AURKB0.66793415
108KSR10.66142588
109CDK80.65836134
110EIF2AK30.65282884
111UHMK10.65036060
112CDK30.64045686
113ITK0.63145932
114PTK60.57608195
115CCNB10.56976436
116IKBKB0.56587271
117BRAF0.56563523
118ADRBK10.55873927
119MARK10.55551861
120MAPK130.52723332
121PTK20.52294057
122SGK20.51998687
123STK38L0.51793702
124CSNK2A10.51515109
125TEC0.49706048
126RPS6KA20.48742976
127MAP3K10.47462469
128STK30.46444725
129MAPKAPK50.45550522
130PDK20.44867515
131MAP3K90.43609360
132CDK10.43292647
133CSNK1E0.43020852
134CAMK2G0.42856862
135AKT30.42603997
136BRD40.42217735
137FGFR20.41456484
138PIM10.40317026
139SGK4940.39896028
140SGK2230.39896028
141PRKDC0.39063663
142CSNK2A20.38962406
143MAP2K60.38685835
144ALK0.38182207
145BLK0.37313799
146MAP3K40.37152431
147CDK20.36890168
148PRKCZ0.36649243
149STK40.36549659
150TSSK60.36242453
151ERN10.36212719
152TNIK0.35249773
153AURKA0.34343657
154CLK10.33440644
155BTK0.33336523
156CDK70.32063095
157CAMK1G0.31465770
158SRC0.31435748
159PAK30.30627700
160EPHA40.30288301
161MAP2K70.30180317
162STK100.30145894
163DYRK20.29313022
164NME20.27918512
165CAMK40.27352150
166MYLK0.26938568
167CSNK1A10.26094762
168TGFBR10.25200905
169STK390.24809230
170JAK10.24638665
171PRKCG0.24475184
172PRKACA0.24258207
173ROCK20.24141983
174DAPK10.23865677
175CDK50.23249493
176PASK0.22995667

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004005.25644962
2Histidine metabolism_Homo sapiens_hsa003403.39014979
3RNA polymerase_Homo sapiens_hsa030203.27472828
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.24114227
5DNA replication_Homo sapiens_hsa030303.17244368
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.15475710
7Mismatch repair_Homo sapiens_hsa034302.97004205
8Homologous recombination_Homo sapiens_hsa034402.96700189
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.76966212
10Non-homologous end-joining_Homo sapiens_hsa034502.59809704
11Fanconi anemia pathway_Homo sapiens_hsa034602.33140906
12Synaptic vesicle cycle_Homo sapiens_hsa047212.31418453
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.30553379
14Asthma_Homo sapiens_hsa053102.24705523
15Protein export_Homo sapiens_hsa030602.19327613
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.19075059
17Arginine biosynthesis_Homo sapiens_hsa002202.17906041
18Spliceosome_Homo sapiens_hsa030402.10150178
19Basal transcription factors_Homo sapiens_hsa030222.05370364
20One carbon pool by folate_Homo sapiens_hsa006702.00803715
21Nucleotide excision repair_Homo sapiens_hsa034201.96492935
22Selenocompound metabolism_Homo sapiens_hsa004501.95815965
23RNA transport_Homo sapiens_hsa030131.93776716
24Base excision repair_Homo sapiens_hsa034101.90806892
25RNA degradation_Homo sapiens_hsa030181.90519236
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.89696399
27Ribosome_Homo sapiens_hsa030101.88548792
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83743884
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.78282864
30Linoleic acid metabolism_Homo sapiens_hsa005911.74530023
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.74147620
32Pyrimidine metabolism_Homo sapiens_hsa002401.71509083
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69801582
34Primary immunodeficiency_Homo sapiens_hsa053401.69028021
35Cell cycle_Homo sapiens_hsa041101.68777328
36Phenylalanine metabolism_Homo sapiens_hsa003601.66539692
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.65281222
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.63831061
39Olfactory transduction_Homo sapiens_hsa047401.60079615
40Antigen processing and presentation_Homo sapiens_hsa046121.57560416
41Melanoma_Homo sapiens_hsa052181.53491865
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44575332
43Collecting duct acid secretion_Homo sapiens_hsa049661.43702467
44Rheumatoid arthritis_Homo sapiens_hsa053231.41670959
45Oxidative phosphorylation_Homo sapiens_hsa001901.39563770
46Fatty acid elongation_Homo sapiens_hsa000621.36352311
47Propanoate metabolism_Homo sapiens_hsa006401.35999154
48Vitamin B6 metabolism_Homo sapiens_hsa007501.33499199
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33204622
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31755191
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31309752
52Purine metabolism_Homo sapiens_hsa002301.30728140
53Leishmaniasis_Homo sapiens_hsa051401.29771287
54Primary bile acid biosynthesis_Homo sapiens_hsa001201.28641209
55Steroid biosynthesis_Homo sapiens_hsa001001.25503017
56Maturity onset diabetes of the young_Homo sapiens_hsa049501.25212184
57Chemokine signaling pathway_Homo sapiens_hsa040621.25136956
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21989044
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16239605
60Phagosome_Homo sapiens_hsa041451.14024865
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.12191046
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10616159
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10242363
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07773743
65Butanoate metabolism_Homo sapiens_hsa006501.07308095
66Vibrio cholerae infection_Homo sapiens_hsa051101.07176399
67Dorso-ventral axis formation_Homo sapiens_hsa043201.04267415
68Ether lipid metabolism_Homo sapiens_hsa005651.03043054
69ABC transporters_Homo sapiens_hsa020101.00604620
70Oocyte meiosis_Homo sapiens_hsa041141.00419051
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95060610
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94539862
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94055089
74Caffeine metabolism_Homo sapiens_hsa002320.92669321
75Parkinsons disease_Homo sapiens_hsa050120.92440380
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90304524
77Nitrogen metabolism_Homo sapiens_hsa009100.90129413
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89476194
79Salivary secretion_Homo sapiens_hsa049700.88152667
80Nicotine addiction_Homo sapiens_hsa050330.87013219
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86591015
82mRNA surveillance pathway_Homo sapiens_hsa030150.85388789
83Arachidonic acid metabolism_Homo sapiens_hsa005900.85382064
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84449512
85Retinol metabolism_Homo sapiens_hsa008300.84244465
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84068800
87Phototransduction_Homo sapiens_hsa047440.83052238
88Tryptophan metabolism_Homo sapiens_hsa003800.81413054
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.78592728
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78473220
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78008717
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77406257
93Osteoclast differentiation_Homo sapiens_hsa043800.76006572
94Prolactin signaling pathway_Homo sapiens_hsa049170.75542662
95Amphetamine addiction_Homo sapiens_hsa050310.74656914
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74215838
97Tuberculosis_Homo sapiens_hsa051520.74049216
98Allograft rejection_Homo sapiens_hsa053300.73741931
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72811309
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72600862
101Metabolic pathways_Homo sapiens_hsa011000.72253946
102African trypanosomiasis_Homo sapiens_hsa051430.71372733
103Alzheimers disease_Homo sapiens_hsa050100.70975077
104p53 signaling pathway_Homo sapiens_hsa041150.70823197
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69567395
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68825433
107Fatty acid metabolism_Homo sapiens_hsa012120.67070718
108Folate biosynthesis_Homo sapiens_hsa007900.66070536
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66035917
110Cholinergic synapse_Homo sapiens_hsa047250.65628006
111Ras signaling pathway_Homo sapiens_hsa040140.65052451
112Proteasome_Homo sapiens_hsa030500.62987701
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62717012
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61657201
115Circadian entrainment_Homo sapiens_hsa047130.61527121
116Circadian rhythm_Homo sapiens_hsa047100.61402109
117Insulin secretion_Homo sapiens_hsa049110.60292473
118Apoptosis_Homo sapiens_hsa042100.57295123
119Taste transduction_Homo sapiens_hsa047420.56639287
120beta-Alanine metabolism_Homo sapiens_hsa004100.56130233
121Cardiac muscle contraction_Homo sapiens_hsa042600.56026097
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55510643
123Thyroid cancer_Homo sapiens_hsa052160.55499216
124Serotonergic synapse_Homo sapiens_hsa047260.55338004
125Amoebiasis_Homo sapiens_hsa051460.54626456
126Hedgehog signaling pathway_Homo sapiens_hsa043400.54437617
127Tyrosine metabolism_Homo sapiens_hsa003500.54180260
128Pyruvate metabolism_Homo sapiens_hsa006200.54072779
129Huntingtons disease_Homo sapiens_hsa050160.53262193
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51854378
131Sulfur relay system_Homo sapiens_hsa041220.51724624
132Fatty acid degradation_Homo sapiens_hsa000710.51401725
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.51204332
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50843323
135Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50778809
136Glutamatergic synapse_Homo sapiens_hsa047240.50491218
137N-Glycan biosynthesis_Homo sapiens_hsa005100.50156926
138Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50143506
139Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49745753
140Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49652987
141Pertussis_Homo sapiens_hsa051330.49228744
142MAPK signaling pathway_Homo sapiens_hsa040100.47836116
143Regulation of autophagy_Homo sapiens_hsa041400.47787356
144Calcium signaling pathway_Homo sapiens_hsa040200.47330479
145Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46893165
146Thyroid hormone synthesis_Homo sapiens_hsa049180.46654349
147Autoimmune thyroid disease_Homo sapiens_hsa053200.46616945
148Toxoplasmosis_Homo sapiens_hsa051450.45923410
149Choline metabolism in cancer_Homo sapiens_hsa052310.45893636
150Drug metabolism - other enzymes_Homo sapiens_hsa009830.45354088
151Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44228154
152Salmonella infection_Homo sapiens_hsa051320.44182422
153Peroxisome_Homo sapiens_hsa041460.42781093
154Phospholipase D signaling pathway_Homo sapiens_hsa040720.42634879
155Jak-STAT signaling pathway_Homo sapiens_hsa046300.42258402
156VEGF signaling pathway_Homo sapiens_hsa043700.41459297
157Glutathione metabolism_Homo sapiens_hsa004800.40801978
158Endocytosis_Homo sapiens_hsa041440.40752085
159Basal cell carcinoma_Homo sapiens_hsa052170.40538241
160Rap1 signaling pathway_Homo sapiens_hsa040150.37499335
161Vitamin digestion and absorption_Homo sapiens_hsa049770.37351065
162Hippo signaling pathway_Homo sapiens_hsa043900.36651619
163SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36029811
164Fat digestion and absorption_Homo sapiens_hsa049750.35976315
165Long-term potentiation_Homo sapiens_hsa047200.35865651
166Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34611759
167Inositol phosphate metabolism_Homo sapiens_hsa005620.34431121
168Glycerolipid metabolism_Homo sapiens_hsa005610.34311165
169Endometrial cancer_Homo sapiens_hsa052130.33934867
170Legionellosis_Homo sapiens_hsa051340.33037640
171Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32580437
172Arginine and proline metabolism_Homo sapiens_hsa003300.31060160
173Gastric acid secretion_Homo sapiens_hsa049710.30999121
174Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30546794
175Lysine degradation_Homo sapiens_hsa003100.30429976
176Wnt signaling pathway_Homo sapiens_hsa043100.28661383
177Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27403001
178Chemical carcinogenesis_Homo sapiens_hsa052040.27256468
179TGF-beta signaling pathway_Homo sapiens_hsa043500.24681848
180Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23899412

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