CALCOCO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)6.00379595
2proline metabolic process (GO:0006560)4.47702988
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.45616151
4establishment of apical/basal cell polarity (GO:0035089)4.33886717
5plasma membrane repair (GO:0001778)4.25601607
6transcription from mitochondrial promoter (GO:0006390)4.24302264
7sarcomere organization (GO:0045214)4.17966859
8carnitine shuttle (GO:0006853)4.15946096
9embryonic process involved in female pregnancy (GO:0060136)4.12052846
10cardiac myofibril assembly (GO:0055003)4.11544102
11negative regulation of potassium ion transmembrane transport (GO:1901380)4.08114627
12regulation of integrin activation (GO:0033623)3.99545519
13regulation of protein homooligomerization (GO:0032462)3.79225135
14positive regulation of protein homooligomerization (GO:0032464)3.73769929
15fatty acid transmembrane transport (GO:1902001)3.73337044
16negative regulation of cell killing (GO:0031342)3.69309346
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.69309346
18oxidative demethylation (GO:0070989)3.68558398
19establishment of monopolar cell polarity (GO:0061162)3.67513112
20establishment or maintenance of monopolar cell polarity (GO:0061339)3.67513112
21myofibril assembly (GO:0030239)3.56318176
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.54177883
23cardiac muscle contraction (GO:0060048)3.51401277
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.46787403
25actin-myosin filament sliding (GO:0033275)3.43562093
26muscle filament sliding (GO:0030049)3.43562093
27embryonic placenta development (GO:0001892)3.43026556
28negative regulation of erythrocyte differentiation (GO:0045647)3.28837314
29stress fiber assembly (GO:0043149)3.27293151
30cardiac muscle cell development (GO:0055013)3.24338872
31protein localization to endosome (GO:0036010)3.22271681
32apoptotic process involved in morphogenesis (GO:0060561)3.20739785
33antigen processing and presentation of endogenous antigen (GO:0019883)3.20228974
34negative regulation of fatty acid biosynthetic process (GO:0045717)3.16390375
35tricarboxylic acid cycle (GO:0006099)3.15318083
36negative regulation of protein oligomerization (GO:0032460)3.14518597
37positive regulation of myotube differentiation (GO:0010831)3.11709902
38actomyosin structure organization (GO:0031032)3.11547703
39antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.11016219
40positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.08581561
41positive regulation of gamma-delta T cell activation (GO:0046645)3.07021897
42membrane tubulation (GO:0097320)3.06960419
43mitotic G1 DNA damage checkpoint (GO:0031571)3.06071109
44cardiac cell development (GO:0055006)3.05969766
45regulation of skeletal muscle contraction (GO:0014819)3.01498354
46negative regulation of Ras GTPase activity (GO:0034261)3.01196105
47carnitine transmembrane transport (GO:1902603)2.97517232
48negative regulation of heart growth (GO:0061117)2.95088575
49negative regulation of cardiac muscle tissue growth (GO:0055022)2.95088575
50negative regulation of cell size (GO:0045792)2.94554616
51cellular response to zinc ion (GO:0071294)2.94454584
52cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.89857627
53regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.89333729
54detection of other organism (GO:0098543)2.87614810
552-oxoglutarate metabolic process (GO:0006103)2.86304700
56sulfur amino acid catabolic process (GO:0000098)2.82683688
57convergent extension (GO:0060026)2.81733636
58glycogen catabolic process (GO:0005980)2.81283996
59detection of bacterium (GO:0016045)2.80669332
60signal complex assembly (GO:0007172)2.79993146
61negative regulation of nucleotide catabolic process (GO:0030812)2.79065799
62striated muscle contraction (GO:0006941)2.79017362
63negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.78657147
64regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.77642363
65amino-acid betaine transport (GO:0015838)2.77020847
66carnitine transport (GO:0015879)2.77020847
67ventricular cardiac muscle cell action potential (GO:0086005)2.75052346
68mitochondrial DNA metabolic process (GO:0032042)2.74064510
69negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.73273207
70protein heterotrimerization (GO:0070208)2.72203609
71anatomical structure regression (GO:0060033)2.72010951
72cell communication involved in cardiac conduction (GO:0086065)2.71203587
73embryonic camera-type eye development (GO:0031076)2.70942312
74regulation of hippo signaling (GO:0035330)2.69333009
75positive regulation of fatty acid beta-oxidation (GO:0032000)2.69313152
76regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.68886959
77actin-mediated cell contraction (GO:0070252)2.67626369
78glutamine family amino acid biosynthetic process (GO:0009084)2.66492846
79cellular response to epinephrine stimulus (GO:0071872)2.65290728
80regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.64860942
81negative regulation of JAK-STAT cascade (GO:0046426)2.64306369
82cell communication by electrical coupling (GO:0010644)2.64006887
83fatty acid beta-oxidation (GO:0006635)2.63990425
84regulation of p38MAPK cascade (GO:1900744)2.63006092
85regulation of cholesterol homeostasis (GO:2000188)2.61873420
86mannose metabolic process (GO:0006013)2.61292151
87respiratory system process (GO:0003016)2.59922335
88regulation of fatty acid oxidation (GO:0046320)2.59870125
89epithelial cell-cell adhesion (GO:0090136)2.58807899
90regulation of early endosome to late endosome transport (GO:2000641)2.58367981
91regulation of cAMP-dependent protein kinase activity (GO:2000479)2.58224413
92regulation of T-helper 2 cell differentiation (GO:0045628)2.57501892
93glucan catabolic process (GO:0009251)2.56778925
94mitotic G1/S transition checkpoint (GO:0044819)2.56778918
95negative regulation of chondrocyte differentiation (GO:0032331)2.56355722
96bundle of His cell to Purkinje myocyte communication (GO:0086069)2.55555910
97positive regulation of receptor recycling (GO:0001921)2.54926343
98regulation of response to reactive oxygen species (GO:1901031)2.54449277
99cardiac muscle hypertrophy (GO:0003300)2.53840944
100G1 DNA damage checkpoint (GO:0044783)2.53402019
101cytoskeletal anchoring at plasma membrane (GO:0007016)2.53324920
102regulation of protein oligomerization (GO:0032459)2.52508650
103regulation of ARF protein signal transduction (GO:0032012)2.51760403
104heart trabecula formation (GO:0060347)2.51718947
105negative regulation of purine nucleotide catabolic process (GO:0033122)2.51531103
106regulation of tight junction assembly (GO:2000810)2.51505567
107regulation of gamma-delta T cell activation (GO:0046643)2.51180717
108negative regulation of cartilage development (GO:0061037)2.50768207
109actin filament-based movement (GO:0030048)2.49081347
110skeletal muscle contraction (GO:0003009)2.48613476
111adherens junction assembly (GO:0034333)2.48333846
112biotin metabolic process (GO:0006768)2.47404981
113detection of external biotic stimulus (GO:0098581)2.46204054
114barbed-end actin filament capping (GO:0051016)2.45859878
115tricarboxylic acid metabolic process (GO:0072350)2.44747123
116retinoic acid receptor signaling pathway (GO:0048384)2.44700912
117regulation of fatty acid beta-oxidation (GO:0031998)2.44648083
118NADH metabolic process (GO:0006734)2.44523568
119regulation of the force of heart contraction (GO:0002026)2.43177434
120germinal center formation (GO:0002467)2.39885380
121regulation of gamma-delta T cell differentiation (GO:0045586)2.39503947
122positive regulation of cellular amide metabolic process (GO:0034250)2.34552558
123negative regulation of lymphocyte mediated immunity (GO:0002707)2.31835326
124negative regulation of leukocyte mediated immunity (GO:0002704)2.30389011
125regulation of B cell receptor signaling pathway (GO:0050855)2.29850347
126modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.28592719
127positive regulation by organism of defense response of other organism involved in symbiotic interact2.28592719
128modulation by symbiont of host immune response (GO:0052553)2.28592719
129positive regulation by symbiont of host defense response (GO:0052509)2.28592719
130modulation by symbiont of host defense response (GO:0052031)2.28592719
131modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.28592719
132positive regulation of Rap GTPase activity (GO:0032854)2.27105650
133detection of molecule of bacterial origin (GO:0032490)2.23955296
134response to epinephrine (GO:0071871)2.21355554
135regulation of ARF GTPase activity (GO:0032312)2.20247877
136macrophage activation involved in immune response (GO:0002281)2.19992897
137negative regulation of type 2 immune response (GO:0002829)2.19822207
138positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.15005224
139regulation of macrophage cytokine production (GO:0010935)2.11966229
140positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.10969881
141response to laminar fluid shear stress (GO:0034616)2.09568121
142fibril organization (GO:0097435)2.08638588
143regulation of platelet aggregation (GO:0090330)2.08025645
144positive thymic T cell selection (GO:0045059)2.07805754
145leukocyte aggregation (GO:0070486)2.07625973
146peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.07622606
147neutrophil activation involved in immune response (GO:0002283)2.05959790
148regulation of necroptotic process (GO:0060544)2.04342860
149detection of biotic stimulus (GO:0009595)2.03413251
150negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.03215211
151cellular response to monoamine stimulus (GO:0071868)2.01700160
152cellular response to catecholamine stimulus (GO:0071870)2.01700160
153regulation of mast cell degranulation (GO:0043304)2.01442122
154regulation of leukocyte degranulation (GO:0043300)2.01219799
155negative regulation of glycoprotein biosynthetic process (GO:0010561)2.01103698
156protein targeting to plasma membrane (GO:0072661)2.00651343
157response to muramyl dipeptide (GO:0032495)2.00605869
158cellular extravasation (GO:0045123)2.00471143
159regulation of myeloid leukocyte mediated immunity (GO:0002886)1.97904003
160regulation of amyloid precursor protein catabolic process (GO:1902991)1.97322946
161regulation of type 2 immune response (GO:0002828)1.97300239
162negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)1.94659850
163regulation of dendritic cell antigen processing and presentation (GO:0002604)1.93665482
164regulation of Rap GTPase activity (GO:0032317)1.91983425
165extracellular fibril organization (GO:0043206)1.91006108
166regulation of tolerance induction (GO:0002643)1.90941320
167activation of protein kinase A activity (GO:0034199)1.89845937
168thymic T cell selection (GO:0045061)1.89385673
169response to type I interferon (GO:0034340)1.87873765
170negative regulation of establishment of protein localization to plasma membrane (GO:0090005)1.87836039
171regulation of beta-amyloid formation (GO:1902003)1.87826499
172negative thymic T cell selection (GO:0045060)1.87787696
173positive regulation of macrophage cytokine production (GO:0060907)1.87722764
174type I interferon signaling pathway (GO:0060337)1.87489346
175cellular response to type I interferon (GO:0071357)1.87489346
176extracellular matrix assembly (GO:0085029)1.87203635
177hypotonic response (GO:0006971)1.86930421
178positive regulation of cholesterol efflux (GO:0010875)1.86876211
179B cell receptor signaling pathway (GO:0050853)1.86472326
180negative regulation of protein localization to plasma membrane (GO:1903077)1.86216934
181positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)1.86192215
182positive regulation of tolerance induction (GO:0002645)1.86123790
183negative regulation of myotube differentiation (GO:0010832)1.85806357
184positive regulation of membrane protein ectodomain proteolysis (GO:0051044)1.85418231
185regulation of T cell tolerance induction (GO:0002664)1.85228577
186negative regulation of stress fiber assembly (GO:0051497)1.84105519
187macroautophagy (GO:0016236)1.83753462
188response to fluid shear stress (GO:0034405)1.82730861
189response to interleukin-15 (GO:0070672)1.82425160
190negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)1.82206518
191negative regulation of T-helper cell differentiation (GO:0045623)1.82206518
192positive regulation of type 2 immune response (GO:0002830)1.82202008
193positive T cell selection (GO:0043368)1.81822857
194T cell selection (GO:0045058)1.81808009
195regulation of mast cell activation involved in immune response (GO:0033006)1.80811730

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.06578837
2SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.69486957
3ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.58588035
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.51920385
5LXR_22292898_ChIP-Seq_THP-1_Human2.51367112
6ZNF263_19887448_ChIP-Seq_K562_Human2.40273474
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.34903711
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.30833676
9ZFP281_18757296_ChIP-ChIP_E14_Mouse2.26593195
10* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.24995973
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.12562120
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.06802271
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06659362
14KDM2B_26808549_Chip-Seq_DND41_Human2.04343740
15ERG_21242973_ChIP-ChIP_JURKAT_Human2.03929512
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.03920270
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.00463070
18ESR2_21235772_ChIP-Seq_MCF-7_Human1.99267966
19TP63_17297297_ChIP-ChIP_HaCaT_Human1.98122409
20RACK7_27058665_Chip-Seq_MCF-7_Human1.92575325
21DROSHA_22980978_ChIP-Seq_HELA_Human1.87642620
22* KDM2B_26808549_Chip-Seq_K562_Human1.84876578
23CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.84768660
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.81713359
25CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.77102500
26ZFP281_27345836_Chip-Seq_ESCs_Mouse1.75544070
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75441609
28ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.74766542
29* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73234488
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.73134527
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.73042818
32VDR_21846776_ChIP-Seq_THP-1_Human1.72614410
33RXR_22158963_ChIP-Seq_LIVER_Mouse1.72325602
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.72154228
35NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.71082953
36SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.70544306
37CLOCK_20551151_ChIP-Seq_293T_Human1.68317378
38NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.68209189
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.64905336
40RUNX_20019798_ChIP-Seq_JUKART_Human1.64640594
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.63221560
42PPARA_22158963_ChIP-Seq_LIVER_Mouse1.62390771
43TBX20_22328084_ChIP-Seq_HEART_Mouse1.61689369
44TBX20_22080862_ChIP-Seq_HEART_Mouse1.61689369
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60070185
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.59263433
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.58156947
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.57449533
49SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.55269039
50MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.54018514
51SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.53342898
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53295506
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.52884497
54EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.51213954
55ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.50909880
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.50273739
57P300_27058665_Chip-Seq_ZR-75-30cells_Human1.49276887
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48182805
59SPI1_23127762_ChIP-Seq_K562_Human1.46043982
60EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43940489
61NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42873725
62FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.42268606
63LXR_22158963_ChIP-Seq_LIVER_Mouse1.40824862
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40495401
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.39046633
66FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.35741462
67IRF8_27001747_Chip-Seq_BMDM_Mouse1.35100722
68TCF7_22412390_ChIP-Seq_EML_Mouse1.34067875
69VDR_24763502_ChIP-Seq_THP-1_Human1.33972920
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33915146
71CREB1_26743006_Chip-Seq_LNCaP_Human1.32767017
72ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.31646521
73POU5F1_16518401_ChIP-PET_MESCs_Mouse1.31509130
74SCL_19346495_ChIP-Seq_HPC-7_Human1.31175380
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29759147
76RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29687270
77CTCF_27219007_Chip-Seq_Bcells_Human1.28606865
78ESR1_21235772_ChIP-Seq_MCF-7_Human1.28215205
79SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28176321
80* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27834129
81Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27051558
82P68_20966046_ChIP-Seq_HELA_Human1.26616511
83RUNX1_27514584_Chip-Seq_MCF-7_Human1.25655340
84TET1_21451524_ChIP-Seq_MESCs_Mouse1.25508422
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25486549
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24946185
87UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22015280
88CTCF_21964334_ChIP-Seq_BJAB-B_Human1.21824929
89NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.21559969
90NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21410928
91* MYC_22102868_ChIP-Seq_BL_Human1.21171535
92SMC4_20622854_ChIP-Seq_HELA_Human1.20868863
93CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20561632
94NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20499372
95KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.20338985
96KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.20338985
97KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.20338985
98* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20106656
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19248959
100MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16732176
101ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16614516
102MYB_21317192_ChIP-Seq_ERMYB_Mouse1.16128015
103VDR_24787735_ChIP-Seq_THP-1_Human1.15584125
104TP53_20018659_ChIP-ChIP_R1E_Mouse1.15215481
105KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14349242
106TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13630643
107PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13044658
108MAF_26560356_Chip-Seq_TH1_Human1.12974165
109TP53_23651856_ChIP-Seq_MEFs_Mouse1.11752854
110KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11708439
111RUNX1_22412390_ChIP-Seq_EML_Mouse1.11695138
112STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11658648
113CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10619382
114GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09866751
115ATF3_27146783_Chip-Seq_COLON_Human1.09848779
116IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08092571
117* TP63_22573176_ChIP-Seq_HFKS_Human1.08005078
118NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.07992192
119GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07963644
120TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06821364
121E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05405855
122STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05239438
123BCOR_27268052_Chip-Seq_Bcells_Human1.04324553
124* RARB_27405468_Chip-Seq_BRAIN_Mouse1.04281317
125RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04273595
126ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04098303
127SA1_27219007_Chip-Seq_ERYTHROID_Human1.03694180
128MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03190556
129POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03121313
130SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02817627
131NANOG_21062744_ChIP-ChIP_HESCs_Human1.01883546
132* TET1_21490601_ChIP-Seq_MESCs_Mouse1.01698155
133UTX_26944678_Chip-Seq_JUKART_Human1.01547274
134GATA1_19941826_ChIP-Seq_K562_Human1.01406294
135LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01325344
136ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01105269
137LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00860835
138STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00774992
139EZH2_22144423_ChIP-Seq_EOC_Human1.00610382
140DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00595659
141E2F1_20622854_ChIP-Seq_HELA_Human0.99339791
142STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99247972
143SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98829957
144GATA2_19941826_ChIP-Seq_K562_Human0.97901047
145IRF8_21731497_ChIP-ChIP_J774_Mouse0.97603998
146MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97177519
147P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96760576
148BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96305502
149CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95894390
150SUZ12_27294783_Chip-Seq_ESCs_Mouse0.90151033
151SMC1_22415368_ChIP-Seq_MEFs_Mouse0.89991845
152BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89318371
153* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89041136
154MAF_26560356_Chip-Seq_TH2_Human0.88846248
155SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.87301872
156SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.86990380

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy4.41155798
2MP0002837_dystrophic_cardiac_calcinosis4.28852295
3MP0004233_abnormal_muscle_weight3.54640525
4MP0004084_abnormal_cardiac_muscle3.12141140
5MP0003724_increased_susceptibility_to2.99007660
6MP0004130_abnormal_muscle_cell2.91607763
7MP0005330_cardiomyopathy2.76049170
8MP0003646_muscle_fatigue2.63683624
9MP0004087_abnormal_muscle_fiber2.61444640
10MP0002269_muscular_atrophy2.60111272
11MP0009278_abnormal_bone_marrow2.58511846
12MP0003436_decreased_susceptibility_to2.53354379
13MP0010030_abnormal_orbit_morphology2.48431203
14MP0000749_muscle_degeneration2.42630733
15MP0003303_peritoneal_inflammation2.41999629
16MP0004036_abnormal_muscle_relaxation2.35173620
17MP0003283_abnormal_digestive_organ2.34331101
18MP0003705_abnormal_hypodermis_morpholog2.27359621
19MP0010630_abnormal_cardiac_muscle2.18420324
20MP0004215_abnormal_myocardial_fiber2.16365343
21MP0003191_abnormal_cellular_cholesterol2.16271471
22MP0003137_abnormal_impulse_conducting2.11203079
23MP0002106_abnormal_muscle_physiology2.02409451
24MP0003300_gastrointestinal_ulcer1.99753894
25MP0004145_abnormal_muscle_electrophysio1.97946489
26MP0000759_abnormal_skeletal_muscle1.94305666
27MP0005503_abnormal_tendon_morphology1.90107274
28MP0000750_abnormal_muscle_regeneration1.89698981
29MP0004510_myositis1.84281407
30MP0000747_muscle_weakness1.84183887
31MP0004185_abnormal_adipocyte_glucose1.80214633
32MP0005666_abnormal_adipose_tissue1.76841447
33MP0008260_abnormal_autophagy1.75082255
34MP0005369_muscle_phenotype1.73776778
35MP0008775_abnormal_heart_ventricle1.72930928
36MP0003690_abnormal_glial_cell1.72356958
37MP0001835_abnormal_antigen_presentation1.66846478
38MP0001533_abnormal_skeleton_physiology1.66530010
39MP0003329_amyloid_beta_deposits1.65292995
40MP0005670_abnormal_white_adipose1.64903343
41MP0005620_abnormal_muscle_contractility1.61146015
42MP0002419_abnormal_innate_immunity1.58995996
43MP0003566_abnormal_cell_adhesion1.58134263
44MP0005171_absent_coat_pigmentation1.57767044
45MP0005623_abnormal_meninges_morphology1.55695355
46MP0003828_pulmonary_edema1.53647476
47MP0005375_adipose_tissue_phenotype1.53609583
48MP0000013_abnormal_adipose_tissue1.52826642
49MP0001544_abnormal_cardiovascular_syste1.52478115
50MP0005385_cardiovascular_system_phenoty1.52478115
51MP0005464_abnormal_platelet_physiology1.51810251
52MP0003045_fibrosis1.50687464
53MP0002909_abnormal_adrenal_gland1.49315705
54MP0004947_skin_inflammation1.48736182
55MP0002108_abnormal_muscle_morphology1.47133849
56MP0005451_abnormal_body_composition1.46533853
57MP0002972_abnormal_cardiac_muscle1.46334864
58MP0002653_abnormal_ependyma_morphology1.45803642
59MP0005025_abnormal_response_to1.43974572
60MP0003091_abnormal_cell_migration1.42716487
61MP0005387_immune_system_phenotype1.42232872
62MP0001790_abnormal_immune_system1.42232872
63MP0008438_abnormal_cutaneous_collagen1.40927261
64MP0006138_congestive_heart_failure1.40718537
65MP0000003_abnormal_adipose_tissue1.39832806
66MP0008961_abnormal_basal_metabolism1.38843429
67MP0002998_abnormal_bone_remodeling1.38371870
68MP0000604_amyloidosis1.34492778
69MP0005000_abnormal_immune_tolerance1.33084054
70MP0005076_abnormal_cell_differentiation1.30671430
71MP0001851_eye_inflammation1.26057263
72MP0000733_abnormal_muscle_development1.25205943
73MP0000685_abnormal_immune_system1.24989035
74MP0003763_abnormal_thymus_physiology1.24970412
75MP0002933_joint_inflammation1.24620573
76MP0008004_abnormal_stomach_pH1.24613182
77MP0001800_abnormal_humoral_immune1.20717085
78MP0000465_gastrointestinal_hemorrhage1.20457213
79MP0006082_CNS_inflammation1.20038720
80MP0000579_abnormal_nail_morphology1.19679773
81MP0003453_abnormal_keratinocyte_physiol1.16746816
82MP0003879_abnormal_hair_cell1.16405629
83MP0003075_altered_response_to1.14117243
84MP0005275_abnormal_skin_tensile1.13482109
85MP0005409_darkened_coat_color1.12973845
86MP0002332_abnormal_exercise_endurance1.12932571
87MP0003567_abnormal_fetal_cardiomyocyte1.12115648
88MP0008995_early_reproductive_senescence1.11161625
89MP0002723_abnormal_immune_serum1.10834179
90MP0005388_respiratory_system_phenotype1.10297741
91MP0002133_abnormal_respiratory_system1.10297741
92MP0003279_aneurysm1.10115470
93MP0002877_abnormal_melanocyte_morpholog1.08930749
94MP0009785_altered_susceptibility_to1.08288236
95MP0002009_preneoplasia1.07901189
96MP0002249_abnormal_larynx_morphology1.07561571
97MP0002971_abnormal_brown_adipose1.06688931
98MP0005058_abnormal_lysosome_morphology1.06682819
99MP0002420_abnormal_adaptive_immunity1.06329882
100MP0004883_abnormal_blood_vessel1.05738141
101MP0003119_abnormal_digestive_system1.05709519
102MP0000266_abnormal_heart_morphology1.05421349
103MP0000920_abnormal_myelination1.03950264
104MP0001819_abnormal_immune_cell1.03701245
105MP0005365_abnormal_bile_salt1.03215276
106MP0005671_abnormal_response_to1.01351472
107MP0004085_abnormal_heartbeat1.01063672
108MP0005164_abnormal_response_to1.01057884
109MP0004133_heterotaxia1.00283950
110MP0003221_abnormal_cardiomyocyte_apopto0.99447454
111MP0002405_respiratory_system_inflammati0.99215918
112MP0000249_abnormal_blood_vessel0.98915218
113MP0002452_abnormal_antigen_presenting0.98871658
114MP0002796_impaired_skin_barrier0.98719312
115MP0005390_skeleton_phenotype0.98597512
116MP0000767_abnormal_smooth_muscle0.98467962
117MP0003183_abnormal_peptide_metabolism0.97570536
118MP0005166_decreased_susceptibility_to0.97032591
119MP0010155_abnormal_intestine_physiology0.95513145
120MP0002234_abnormal_pharynx_morphology0.95218495
121MP0008569_lethality_at_weaning0.93535169
122MP0001849_ear_inflammation0.92490791
123MP0002127_abnormal_cardiovascular_syste0.91721041
124MP0009115_abnormal_fat_cell0.91124735
125MP0000858_altered_metastatic_potential0.90183958
126MP0000639_abnormal_adrenal_gland0.89684151
127MP0008874_decreased_physiological_sensi0.89436294
128MP0003656_abnormal_erythrocyte_physiolo0.88691140
129MP0005023_abnormal_wound_healing0.87530158
130MP0004484_altered_response_of0.87450695
131MP0003172_abnormal_lysosome_physiology0.86900608
132MP0009384_cardiac_valve_regurgitation0.84341078
133MP0006072_abnormal_retinal_apoptosis0.84315916
134MP0001545_abnormal_hematopoietic_system0.83992851
135MP0005397_hematopoietic_system_phenotyp0.83992851
136MP0004381_abnormal_hair_follicle0.82874232
137MP0002282_abnormal_trachea_morphology0.82473119
138MP0009840_abnormal_foam_cell0.82396238
139MP0005085_abnormal_gallbladder_physiolo0.81336994
140MP0002060_abnormal_skin_morphology0.80910255
141MP0002148_abnormal_hypersensitivity_rea0.80842452
142MP0005535_abnormal_body_temperature0.79536423
143MP0009780_abnormal_chondrocyte_physiolo0.79508069
144MP0010352_gastrointestinal_tract_polyps0.78661605
145MP0005595_abnormal_vascular_smooth0.78199807
146MP0001542_abnormal_bone_strength0.77953694
147MP0004859_abnormal_synaptic_plasticity0.74765962
148MP0002925_abnormal_cardiovascular_devel0.73467967
149MP0003935_abnormal_craniofacial_develop0.73228705
150MP0004272_abnormal_basement_membrane0.71840672
151MP0005266_abnormal_metabolism0.71274921
152MP0001958_emphysema0.69655495
153MP0005508_abnormal_skeleton_morphology0.69346236
154MP0002970_abnormal_white_adipose0.68153832
155MP0000467_abnormal_esophagus_morphology0.68039233
156MP0004197_abnormal_fetal_growth/weight/0.67208189
157MP0002084_abnormal_developmental_patter0.66106088
158MP0001784_abnormal_fluid_regulation0.65569170
159MP0002128_abnormal_blood_circulation0.64769838
160MP0002086_abnormal_extraembryonic_tissu0.63250268
161MP0000343_altered_response_to0.62755481
162MP0000762_abnormal_tongue_morphology0.60344707
163MP0010368_abnormal_lymphatic_system0.59536153
164MP0002118_abnormal_lipid_homeostasis0.59345474

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.13116207
2Sudden death (HP:0001699)4.49820825
3Asymmetric septal hypertrophy (HP:0001670)3.97997233
4Hyporeflexia of lower limbs (HP:0002600)3.72677814
5Muscle fiber splitting (HP:0003555)3.69689927
6Myoglobinuria (HP:0002913)3.67171516
7Cerebral aneurysm (HP:0004944)3.67013511
8Turricephaly (HP:0000262)3.65691694
9Eczematoid dermatitis (HP:0000976)3.64912083
10Ventricular tachycardia (HP:0004756)3.62277545
11Increased connective tissue (HP:0009025)3.47639229
12Exercise-induced muscle cramps (HP:0003710)3.43071124
13Right ventricular cardiomyopathy (HP:0011663)3.40897338
14Type 1 muscle fiber predominance (HP:0003803)3.33138350
15Difficulty running (HP:0009046)3.22321593
16Calf muscle hypertrophy (HP:0008981)3.20267743
17Aortic aneurysm (HP:0004942)3.14356083
18Increased IgE level (HP:0003212)3.11503314
19Annular pancreas (HP:0001734)3.05353238
20Muscle hypertrophy of the lower extremities (HP:0008968)2.99367954
21Abnormality of the calf musculature (HP:0001430)2.99191432
22Obstructive sleep apnea (HP:0002870)2.98590695
23Large for gestational age (HP:0001520)2.98323532
24Difficulty climbing stairs (HP:0003551)2.91203742
25Ulnar bowing (HP:0003031)2.87418251
26Atrial fibrillation (HP:0005110)2.85969920
27Alopecia of scalp (HP:0002293)2.76582226
28Ketoacidosis (HP:0001993)2.75195894
29Polycythemia (HP:0001901)2.73241235
30Primary atrial arrhythmia (HP:0001692)2.73067213
31Myotonia (HP:0002486)2.69470265
32Bundle branch block (HP:0011710)2.68713876
33Rib fusion (HP:0000902)2.67494857
34Spontaneous hematomas (HP:0007420)2.67118428
35Abnormality of the left ventricular outflow tract (HP:0011103)2.66372160
36Subaortic stenosis (HP:0001682)2.66372160
37Vascular tortuosity (HP:0004948)2.63181924
38Increased variability in muscle fiber diameter (HP:0003557)2.61206815
39Mildly elevated creatine phosphokinase (HP:0008180)2.60328115
40Prolonged bleeding time (HP:0003010)2.60256809
41Lipoatrophy (HP:0100578)2.58977249
42Supraventricular arrhythmia (HP:0005115)2.57797595
43EMG: myopathic abnormalities (HP:0003458)2.57692023
44Supraventricular tachycardia (HP:0004755)2.56553129
45Broad metatarsal (HP:0001783)2.54006064
46Hypercortisolism (HP:0001578)2.49815265
47Ventricular arrhythmia (HP:0004308)2.48011221
48Arterial tortuosity (HP:0005116)2.45322833
49Atrioventricular block (HP:0001678)2.44288239
50Hypoplastic ischia (HP:0003175)2.43754606
51Peritonitis (HP:0002586)2.42437491
52Diaphragmatic weakness (HP:0009113)2.41452280
53Myositis (HP:0100614)2.40949753
54Growth hormone excess (HP:0000845)2.39150205
55Distal lower limb muscle weakness (HP:0009053)2.38718952
56EMG: neuropathic changes (HP:0003445)2.37885576
57Abnormality of skeletal muscle fiber size (HP:0012084)2.36800106
58Aortic dissection (HP:0002647)2.36668448
59Abnormality of macrophages (HP:0004311)2.32957412
60Interstitial pulmonary disease (HP:0006530)2.31469765
61Recurrent bacterial skin infections (HP:0005406)2.31147932
62Gingivitis (HP:0000230)2.30834233
63Coronal craniosynostosis (HP:0004440)2.30819012
64Pancreatic islet-cell hyperplasia (HP:0004510)2.29313826
65Heart block (HP:0012722)2.29240495
66Syncope (HP:0001279)2.27437150
67Generalized amyotrophy (HP:0003700)2.26284933
68Recurrent abscess formation (HP:0002722)2.25886934
69Neck muscle weakness (HP:0000467)2.25324224
70Male infertility (HP:0003251)2.23445996
71Neurofibrillary tangles (HP:0002185)2.23439989
72Bulbar palsy (HP:0001283)2.23162877
73Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.21926515
74Round ear (HP:0100830)2.21019390
75Abnormal atrioventricular conduction (HP:0005150)2.20392690
76Dilatation of the ascending aorta (HP:0005111)2.18987087
77Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.18248052
78Muscle fiber inclusion bodies (HP:0100299)2.17097614
79Abnormality of the ischium (HP:0003174)2.15836511
80Prolonged QT interval (HP:0001657)2.14508067
81Congenital hip dislocation (HP:0001374)2.11931345
82Orchitis (HP:0100796)2.11677882
83Purpura (HP:0000979)2.11347433
84Centrally nucleated skeletal muscle fibers (HP:0003687)2.11173785
85Systemic lupus erythematosus (HP:0002725)2.10466226
86Aneurysm (HP:0002617)2.09289260
87Papilledema (HP:0001085)2.08144567
88Ventricular fibrillation (HP:0001663)2.07209387
89Ketosis (HP:0001946)2.06605007
90Epistaxis (HP:0000421)2.05177112
91Abnormality of the lower motor neuron (HP:0002366)2.04823422
92Palpitations (HP:0001962)2.04614801
93Gastrointestinal infarctions (HP:0005244)2.04566166
94Dilated cardiomyopathy (HP:0001644)2.04444087
95Recurrent gram-negative bacterial infections (HP:0005420)2.03924766
96Rhabdomyolysis (HP:0003201)2.02449963
97Distal lower limb amyotrophy (HP:0008944)2.02268604
98Urinary glycosaminoglycan excretion (HP:0003541)2.01677556
99Mucopolysacchariduria (HP:0008155)2.01677556
100Emphysema (HP:0002097)1.98930662
101Abnormality of the neuromuscular junction (HP:0003398)1.97181740
102Fatigable weakness (HP:0003473)1.97181740
103Vertebral compression fractures (HP:0002953)1.96929608
104Popliteal pterygium (HP:0009756)1.96775302
105Abnormality of the nasal mucosa (HP:0000433)1.96669016
106Cerebral inclusion bodies (HP:0100314)1.96304305
107Gingival bleeding (HP:0000225)1.96215835
108Protrusio acetabuli (HP:0003179)1.95556309
109Lymphangioma (HP:0100764)1.95144446
110Ulnar deviation of the wrist (HP:0003049)1.94040407
111Abnormality of binocular vision (HP:0011514)1.93505769
112Diplopia (HP:0000651)1.93505769
113Cervical subluxation (HP:0003308)1.92610684
114Supranuclear gaze palsy (HP:0000605)1.91063845
115Nemaline bodies (HP:0003798)1.89792197
116Narrow nasal bridge (HP:0000446)1.89453072
117Muscle stiffness (HP:0003552)1.89142596
118Gowers sign (HP:0003391)1.89001880
119Premature skin wrinkling (HP:0100678)1.88367650
120Abnormal EKG (HP:0003115)1.87472959
121Abnormality of the aortic arch (HP:0012303)1.87394842
122Hamartoma of the eye (HP:0010568)1.86138112
123Muscle fibrillation (HP:0010546)1.85689287
124Broad face (HP:0000283)1.85674232
125Abnormality of mucopolysaccharide metabolism (HP:0011020)1.85239834
126Abnormality of polysaccharide metabolism (HP:0011012)1.85239834
127Abnormality of glycosaminoglycan metabolism (HP:0004371)1.85239834
128Ankle contracture (HP:0006466)1.84877934
129Cellulitis (HP:0100658)1.84133987
130Neoplasm of the heart (HP:0100544)1.83595001
131Bowing of the arm (HP:0006488)1.83288074
132Bowed forearm bones (HP:0003956)1.83288074
133Amyloidosis (HP:0011034)1.82735403
134Concave nail (HP:0001598)1.80989322
135Myopathic facies (HP:0002058)1.80557024
136Spondylolisthesis (HP:0003302)1.78739699
137Chest pain (HP:0100749)1.77543188
138Premature rupture of membranes (HP:0001788)1.77180396
139Testicular atrophy (HP:0000029)1.76552370
140Elevated erythrocyte sedimentation rate (HP:0003565)1.76092313
141Dysmetric saccades (HP:0000641)1.75921643
142Foot dorsiflexor weakness (HP:0009027)1.75625814
143Scapular winging (HP:0003691)1.75555580
144Dysostosis multiplex (HP:0000943)1.75287950
145Hamartoma (HP:0010566)1.75144988
146Nasal polyposis (HP:0100582)1.74881479
147Spinal rigidity (HP:0003306)1.74799999
148Onion bulb formation (HP:0003383)1.74650685
149Anteriorly placed anus (HP:0001545)1.74321723
150Ankle clonus (HP:0011448)1.72665650
151Rapidly progressive (HP:0003678)1.71586980
152Optic neuritis (HP:0100653)1.71334685
153Retrobulbar optic neuritis (HP:0100654)1.71334685
154Abnormality of the fingertips (HP:0001211)1.70889732
155Wormian bones (HP:0002645)1.69796300
156Colitis (HP:0002583)1.67547989
157Hypoplasia of the iris (HP:0007676)1.67196462
158Abnormality of the foot musculature (HP:0001436)1.63998765
159Striae distensae (HP:0001065)1.63751974
160Hypertriglyceridemia (HP:0002155)1.61962375
161Lower limb amyotrophy (HP:0007210)1.60369631
162Atrophic scars (HP:0001075)1.59421943
163Inflammation of the large intestine (HP:0002037)1.57985582
164Hemorrhage of the eye (HP:0011885)1.57729162
165Menorrhagia (HP:0000132)1.56880753
166Segmental peripheral demyelination/remyelination (HP:0003481)1.56115827
167Gastrointestinal inflammation (HP:0004386)1.55610870

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.52335535
2TRIB33.85886645
3DDR23.74761985
4MAPK153.10557873
5PDGFRA2.86441462
6TTN2.72818162
7PINK12.69532299
8RIPK42.61176950
9TYRO32.53274928
10PHKG22.47481928
11PHKG12.47481928
12MAP3K62.38252897
13RIPK12.10288514
14MAP3K111.94659066
15DYRK1B1.81826003
16TYK21.81404286
17MAP2K31.81330544
18PRKD21.72362193
19MAP4K11.70769436
20BMX1.69815715
21DMPK1.69157051
22PKN21.62684788
23ZAP701.61055810
24SIK11.60696080
25MATK1.60439093
26FGR1.54161072
27BLK1.50990684
28TNK21.48934750
29FES1.46444029
30DAPK11.45518089
31UHMK11.42849799
32LMTK21.37794550
33MAP3K131.37596156
34JAK11.36364400
35BCKDK1.33323759
36CDC42BPA1.31863466
37MAP3K31.26650481
38TRPM71.24168224
39EPHA31.23163701
40MAP3K101.21159627
41CSK1.20070736
42JAK31.13708783
43LATS21.13407524
44ERN11.12787711
45OBSCN1.09252070
46TBK11.06812375
47MAPK71.05967907
48GRK61.05015555
49PDK41.04029638
50PDK31.04029638
51PIK3CG1.03421254
52MAPK111.02174766
53MAP3K11.01943715
54NEK11.00382076
55MAPKAPK30.97989721
56RPS6KL10.97180942
57RPS6KC10.97180942
58STK380.96121986
59HCK0.95871993
60PDPK10.93770457
61PRKAA10.93582557
62MTOR0.93421071
63JAK20.91587044
64PRKD10.91316120
65BTK0.90867686
66CDK60.90536582
67SGK30.87025587
68CAMKK10.86218243
69PRKD30.85403497
70TESK10.85389903
71PDK10.85087546
72SYK0.83935031
73MYLK0.83446982
74RPS6KA60.82549419
75PDGFRB0.80700759
76TAOK10.80589969
77MAP3K70.80007761
78PTK20.79835884
79RPS6KA20.79192730
80PTK2B0.76940151
81TXK0.76597586
82FGFR30.76543024
83SGK20.75062561
84EEF2K0.74796412
85MAP3K90.73999432
86SGK2230.73012894
87SGK4940.73012894
88IKBKE0.72014889
89PTK60.71643004
90FGFR40.71513789
91GSK3A0.71437287
92KIT0.70238034
93PIM20.67968483
94WNK10.66617025
95MARK10.66546894
96NEK90.65513005
97HIPK20.65016868
98IRAK40.64979900
99CAMK10.64164483
100CAMK1D0.63400434
101ITK0.62662297
102FYN0.62336452
103TIE10.62229538
104DAPK20.61580310
105RPS6KA10.61059770
106LATS10.60984436
107PRKAA20.60352335
108AKT30.60267857
109CDK120.60065540
110PAK60.59638067
111MAP3K140.56621177
112FLT30.56145028
113ILK0.54984177
114PAK30.54852568
115PRKCH0.54792680
116FGFR10.54709481
117LCK0.54368803
118NTRK30.53179086
119MAPK40.52678945
120MARK20.52268685
121TGFBR20.50947749
122CSF1R0.50613156
123PDK20.48954907
124EPHB10.48929211
125FGFR20.48539534
126TAOK20.46390272
127MAP2K40.45949935
128GRK50.45846619
129DAPK30.44185008
130CAMK1G0.43609350
131PRPF4B0.43531433
132EPHB20.43400504
133CAMK40.43159079
134FER0.39035021
135PAK20.37690322
136CAMK2D0.37473388
137NTRK10.37236296
138RET0.35863131
139SIK20.35543675
140CAMK2G0.35500905
141SGK10.34870172
142KSR20.33997638
143MAPK120.33095777
144LRRK20.31876764
145NTRK20.31121361
146RPS6KA30.30989726
147PIM10.30624508
148ROCK10.30510371
149CDK70.29195170
150PAK40.28769780

Predicted pathways (KEGG)

RankGene SetZ-score
12-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.76007119
2Fatty acid biosynthesis_Homo sapiens_hsa000613.54546667
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.33673783
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.51872365
5Fatty acid metabolism_Homo sapiens_hsa012122.46935199
6Dilated cardiomyopathy_Homo sapiens_hsa054142.11833543
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.91122632
8Fatty acid degradation_Homo sapiens_hsa000711.88581442
9Propanoate metabolism_Homo sapiens_hsa006401.86054146
10mTOR signaling pathway_Homo sapiens_hsa041501.77518605
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.72463050
12Circadian rhythm_Homo sapiens_hsa047101.70123014
13Osteoclast differentiation_Homo sapiens_hsa043801.68028178
14Nitrogen metabolism_Homo sapiens_hsa009101.67259014
15Notch signaling pathway_Homo sapiens_hsa043301.62543678
16Longevity regulating pathway - mammal_Homo sapiens_hsa042111.58368116
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51698061
18Arginine biosynthesis_Homo sapiens_hsa002201.50864354
19Lysine degradation_Homo sapiens_hsa003101.50091451
20Adherens junction_Homo sapiens_hsa045201.48408282
21Biosynthesis of amino acids_Homo sapiens_hsa012301.47258992
22Staphylococcus aureus infection_Homo sapiens_hsa051501.43652652
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37430542
24Malaria_Homo sapiens_hsa051441.35611559
25Other glycan degradation_Homo sapiens_hsa005111.35526855
26Insulin signaling pathway_Homo sapiens_hsa049101.35525193
27Cardiac muscle contraction_Homo sapiens_hsa042601.34895530
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.31483733
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.30645519
30Leishmaniasis_Homo sapiens_hsa051401.30087924
31AMPK signaling pathway_Homo sapiens_hsa041521.28891666
32Carbon metabolism_Homo sapiens_hsa012001.28078534
33Platelet activation_Homo sapiens_hsa046111.24495766
34Hippo signaling pathway_Homo sapiens_hsa043901.23909299
35B cell receptor signaling pathway_Homo sapiens_hsa046621.22833934
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20398844
37Focal adhesion_Homo sapiens_hsa045101.19871419
38Phospholipase D signaling pathway_Homo sapiens_hsa040721.18223289
39Glucagon signaling pathway_Homo sapiens_hsa049221.17825674
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16937040
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16620805
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.15759311
43Insulin resistance_Homo sapiens_hsa049311.13330549
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.13161349
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.12350723
46PPAR signaling pathway_Homo sapiens_hsa033201.12318217
47Long-term potentiation_Homo sapiens_hsa047201.11583098
48Tuberculosis_Homo sapiens_hsa051521.10079555
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07670925
50Bladder cancer_Homo sapiens_hsa052191.06615281
51Pyruvate metabolism_Homo sapiens_hsa006201.05846668
52Tight junction_Homo sapiens_hsa045301.04649364
53Arginine and proline metabolism_Homo sapiens_hsa003301.02802968
54Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02322916
55Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01307435
56Hedgehog signaling pathway_Homo sapiens_hsa043401.01306581
57Toxoplasmosis_Homo sapiens_hsa051451.00993790
58VEGF signaling pathway_Homo sapiens_hsa043701.00309762
59Neurotrophin signaling pathway_Homo sapiens_hsa047221.00014493
60Chemokine signaling pathway_Homo sapiens_hsa040620.99794816
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99026386
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.98850434
63Viral myocarditis_Homo sapiens_hsa054160.98528669
64Non-small cell lung cancer_Homo sapiens_hsa052230.97625870
65T cell receptor signaling pathway_Homo sapiens_hsa046600.96966105
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95293230
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94936753
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92681052
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89888765
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.89395546
71Pertussis_Homo sapiens_hsa051330.88938410
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.87576690
73Proteoglycans in cancer_Homo sapiens_hsa052050.87054657
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86614602
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85709229
76Renal cell carcinoma_Homo sapiens_hsa052110.84958477
77TNF signaling pathway_Homo sapiens_hsa046680.83608386
78Graft-versus-host disease_Homo sapiens_hsa053320.83477468
79Phagosome_Homo sapiens_hsa041450.82942059
80Gap junction_Homo sapiens_hsa045400.82122723
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80011492
82Hematopoietic cell lineage_Homo sapiens_hsa046400.79977786
83Chronic myeloid leukemia_Homo sapiens_hsa052200.79954903
84Allograft rejection_Homo sapiens_hsa053300.79621188
85Pancreatic cancer_Homo sapiens_hsa052120.79391095
86Basal cell carcinoma_Homo sapiens_hsa052170.78745100
87Lysosome_Homo sapiens_hsa041420.78493011
88Inositol phosphate metabolism_Homo sapiens_hsa005620.76798141
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76692057
90Hepatitis C_Homo sapiens_hsa051600.76568890
91Prolactin signaling pathway_Homo sapiens_hsa049170.76523071
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75788515
93Autoimmune thyroid disease_Homo sapiens_hsa053200.74413941
94Oxytocin signaling pathway_Homo sapiens_hsa049210.74220909
95Tryptophan metabolism_Homo sapiens_hsa003800.72754899
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72675915
97Dorso-ventral axis formation_Homo sapiens_hsa043200.72439755
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.72057195
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71930487
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70325276
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.69646610
102Influenza A_Homo sapiens_hsa051640.69507836
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68013338
104Wnt signaling pathway_Homo sapiens_hsa043100.67935819
105Butanoate metabolism_Homo sapiens_hsa006500.67899197
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67562839
107Bile secretion_Homo sapiens_hsa049760.66620670
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66543839
109Fructose and mannose metabolism_Homo sapiens_hsa000510.66477621
110ECM-receptor interaction_Homo sapiens_hsa045120.65772259
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65711261
112Endometrial cancer_Homo sapiens_hsa052130.65133331
113Insulin secretion_Homo sapiens_hsa049110.64707699
114Gastric acid secretion_Homo sapiens_hsa049710.64557013
115FoxO signaling pathway_Homo sapiens_hsa040680.63988418
116Cholinergic synapse_Homo sapiens_hsa047250.63984672
117Synaptic vesicle cycle_Homo sapiens_hsa047210.63340249
118GnRH signaling pathway_Homo sapiens_hsa049120.63227475
119Starch and sucrose metabolism_Homo sapiens_hsa005000.63211287
120Measles_Homo sapiens_hsa051620.63043026
121Prion diseases_Homo sapiens_hsa050200.62671420
122Estrogen signaling pathway_Homo sapiens_hsa049150.62657300
123Salmonella infection_Homo sapiens_hsa051320.60258056
124Olfactory transduction_Homo sapiens_hsa047400.60126902
125Type II diabetes mellitus_Homo sapiens_hsa049300.60116097
126Renin secretion_Homo sapiens_hsa049240.58795507
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58395883
128ErbB signaling pathway_Homo sapiens_hsa040120.57280852
129Glioma_Homo sapiens_hsa052140.57272680
130Small cell lung cancer_Homo sapiens_hsa052220.53182809
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53044300
132Amoebiasis_Homo sapiens_hsa051460.52762367
133Glycerolipid metabolism_Homo sapiens_hsa005610.52672435
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52108067
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51915349
136TGF-beta signaling pathway_Homo sapiens_hsa043500.49385248
137HIF-1 signaling pathway_Homo sapiens_hsa040660.49220143
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.48700357
139AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48507889
140Choline metabolism in cancer_Homo sapiens_hsa052310.48228689
141Acute myeloid leukemia_Homo sapiens_hsa052210.47230668
142Melanogenesis_Homo sapiens_hsa049160.46559513
143Rap1 signaling pathway_Homo sapiens_hsa040150.46164394
144Maturity onset diabetes of the young_Homo sapiens_hsa049500.45957593
145cAMP signaling pathway_Homo sapiens_hsa040240.45839826
146Calcium signaling pathway_Homo sapiens_hsa040200.45099196
147Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44074502
148Endocytosis_Homo sapiens_hsa041440.43206005
149Colorectal cancer_Homo sapiens_hsa052100.42288724
150Circadian entrainment_Homo sapiens_hsa047130.41432022
151Caffeine metabolism_Homo sapiens_hsa002320.38979464
152beta-Alanine metabolism_Homo sapiens_hsa004100.38907089
153MAPK signaling pathway_Homo sapiens_hsa040100.38088545

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