CALCR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1anterior/posterior axis specification, embryo (GO:0008595)6.56434347
2serotonin metabolic process (GO:0042428)6.23054086
3G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071996.00937881
4axonal fasciculation (GO:0007413)5.71340813
5neuron recognition (GO:0008038)5.50378248
6proline transport (GO:0015824)5.38125206
7macroautophagy (GO:0016236)5.34285843
8primary amino compound metabolic process (GO:1901160)5.17751341
9negative regulation of microtubule depolymerization (GO:0007026)5.06657258
10cell migration involved in gastrulation (GO:0042074)5.05157295
11mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.91882857
12positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.91882857
13positive regulation of cellular response to oxidative stress (GO:1900409)4.80733810
14positive regulation of response to oxidative stress (GO:1902884)4.80733810
15primitive streak formation (GO:0090009)4.79921885
16dendritic spine morphogenesis (GO:0060997)4.76967068
17eating behavior (GO:0042755)4.70736752
18regulation of microtubule depolymerization (GO:0031114)4.67265580
19regulation of centriole replication (GO:0046599)4.58894004
20positive regulation of synapse assembly (GO:0051965)4.57688321
21signal transduction involved in regulation of gene expression (GO:0023019)4.51014496
22regulation of transforming growth factor beta2 production (GO:0032909)4.45545068
23negative regulation of microtubule polymerization or depolymerization (GO:0031111)4.43268849
24regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.42446671
25DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.37780782
26respiratory system process (GO:0003016)4.36723185
27establishment of planar polarity (GO:0001736)4.35900779
28establishment of tissue polarity (GO:0007164)4.35900779
29intra-S DNA damage checkpoint (GO:0031573)4.35427373
30regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901214.31511601
31response to misfolded protein (GO:0051788)4.27568606
32regulation of hydrogen peroxide metabolic process (GO:0010310)4.27453584
33cerebellar Purkinje cell differentiation (GO:0021702)4.25283934
34vagina development (GO:0060068)4.20897730
35DNA damage response, signal transduction resulting in transcription (GO:0042772)4.20703316
36female gonad development (GO:0008585)4.18968656
37embryonic foregut morphogenesis (GO:0048617)4.14619188
38regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.07849488
39anterior/posterior axis specification (GO:0009948)4.03924417
40transmission of nerve impulse (GO:0019226)4.02344392
41regulation of cardioblast differentiation (GO:0051890)3.99158603
42negative regulation of organelle assembly (GO:1902116)3.95831516
43regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.94015761
44mitotic metaphase plate congression (GO:0007080)3.90963603
45positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.90747244
46endoderm formation (GO:0001706)3.89137340
47cellular response to epinephrine stimulus (GO:0071872)3.86939827
48response to pheromone (GO:0019236)3.86063256
49regulation of cell communication by electrical coupling (GO:0010649)3.84828090
50pyrimidine nucleobase catabolic process (GO:0006208)3.81370452
51negative regulation of circadian rhythm (GO:0042754)3.77057658
52regulation of synaptic vesicle transport (GO:1902803)3.76745674
53CENP-A containing nucleosome assembly (GO:0034080)3.73383809
54negative regulation of microtubule polymerization (GO:0031115)3.71663638
55spinal cord association neuron differentiation (GO:0021527)3.71345691
56axon extension (GO:0048675)3.69528400
57positive regulation of transforming growth factor beta production (GO:0071636)3.66670502
58neuron cell-cell adhesion (GO:0007158)3.65822671
59female genitalia development (GO:0030540)3.65633622
60chromatin remodeling at centromere (GO:0031055)3.65293281
61protein localization to kinetochore (GO:0034501)3.61162978
62positive regulation of mitochondrial membrane permeability (GO:0035794)3.58865316
63layer formation in cerebral cortex (GO:0021819)3.58846409
64regulation of relaxation of muscle (GO:1901077)3.56582905
65embryonic axis specification (GO:0000578)3.53347681
66positive regulation of cardiac muscle cell proliferation (GO:0060045)3.52700208
67lysosome localization (GO:0032418)3.51988265
68nucleoside transmembrane transport (GO:1901642)3.50490024
69negative regulation of cell fate specification (GO:0009996)3.48978316
70cardiac right ventricle morphogenesis (GO:0003215)3.45957407
71genetic imprinting (GO:0071514)3.45599481
72metaphase plate congression (GO:0051310)3.45520424
73histone exchange (GO:0043486)3.44295564
74vocalization behavior (GO:0071625)3.42725378
75negative regulation of activin receptor signaling pathway (GO:0032926)3.40464220
76regulation of glutamate receptor signaling pathway (GO:1900449)3.39922528
77protein-cofactor linkage (GO:0018065)3.38741047
78lateral sprouting from an epithelium (GO:0060601)3.37252521
79regulation of synapse assembly (GO:0051963)3.33672169
80glutamate secretion (GO:0014047)3.31800885
81facial nerve structural organization (GO:0021612)3.29365841
82peptidyl-arginine omega-N-methylation (GO:0035247)3.28559297
83gastrulation (GO:0007369)3.24266977
84negative regulation of axon extension involved in axon guidance (GO:0048843)3.23596381
85homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)3.22721016
86regulation of cardiac muscle cell contraction (GO:0086004)3.18883443
87alanine transport (GO:0032328)3.17830239
88response to BMP (GO:0071772)3.17206759
89cellular response to BMP stimulus (GO:0071773)3.17206759
90adrenergic receptor signaling pathway (GO:0071875)3.15950575
91urogenital system development (GO:0001655)3.14970562
92cell surface receptor signaling pathway involved in heart development (GO:0061311)3.13391615
93establishment of mitochondrion localization (GO:0051654)3.12915423
94presynaptic membrane organization (GO:0097090)3.12169881
95dendrite morphogenesis (GO:0048813)3.11233717
96positive regulation of cardiac muscle tissue growth (GO:0055023)3.09993486
97regulation of mesoderm development (GO:2000380)3.09184320
98neuron projection extension (GO:1990138)3.09154194
99nerve growth factor signaling pathway (GO:0038180)3.07917754
100ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.07658403
101nodal signaling pathway (GO:0038092)3.06977361
102synaptic vesicle exocytosis (GO:0016079)3.05092265
103cellular response to monoamine stimulus (GO:0071868)3.04294138
104cellular response to catecholamine stimulus (GO:0071870)3.04294138
105positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.03764381
106post-anal tail morphogenesis (GO:0036342)3.03705406
107response to epinephrine (GO:0071871)3.03600991
108positive regulation of heart rate (GO:0010460)3.03045264
109DNA replication-independent nucleosome assembly (GO:0006336)3.00856556
110DNA replication-independent nucleosome organization (GO:0034724)3.00856556
111DNA double-strand break processing (GO:0000729)3.00847867
112prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.00797512
113nucleobase catabolic process (GO:0046113)3.00245506
114forebrain neuron differentiation (GO:0021879)2.99667693
115regulation of hydrogen peroxide-induced cell death (GO:1903205)2.98832443
116regulation of activin receptor signaling pathway (GO:0032925)2.97951203
117limb bud formation (GO:0060174)2.97165846
118regulation of microtubule-based movement (GO:0060632)2.96209433
119mitotic sister chromatid cohesion (GO:0007064)2.95413126
120outflow tract septum morphogenesis (GO:0003148)2.94387778
121regulation of microtubule polymerization or depolymerization (GO:0031110)2.94022460
122protein localization to synapse (GO:0035418)2.93812228
123uterus development (GO:0060065)2.93394427
124cranial nerve structural organization (GO:0021604)2.92687268
125histone arginine methylation (GO:0034969)2.92494898
126positive regulation of receptor biosynthetic process (GO:0010870)2.92422098
127notochord development (GO:0030903)2.91215926
128negative regulation of embryonic development (GO:0045992)2.90162020
129maternal behavior (GO:0042711)2.89175035
130establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.88249045
131mitochondrion transport along microtubule (GO:0047497)2.88249045
132dorsal/ventral axis specification (GO:0009950)2.87027968
133kinetochore organization (GO:0051383)2.86929485
134negative regulation of cell fate commitment (GO:0010454)2.86742285
135embryonic pattern specification (GO:0009880)2.86490166
136negative regulation of axon guidance (GO:1902668)2.86451075
137ventricular cardiac muscle cell development (GO:0055015)2.85410381
138ionotropic glutamate receptor signaling pathway (GO:0035235)2.85387063
139neurotransmitter secretion (GO:0007269)2.84697270
140sequestering of extracellular ligand from receptor (GO:0035581)2.83149059
141kinetochore assembly (GO:0051382)2.82976105
142anatomical structure arrangement (GO:0048532)2.82665073
143peptidyl-arginine N-methylation (GO:0035246)2.82559933
144peptidyl-arginine methylation (GO:0018216)2.82559933
145regulation of axon extension involved in axon guidance (GO:0048841)2.81737915
146startle response (GO:0001964)2.81283735
147regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.80663384
148SMAD protein signal transduction (GO:0060395)2.79928168
149protein localization to chromosome, centromeric region (GO:0071459)2.79532600
150neuromuscular process controlling posture (GO:0050884)2.78658863
151mesenchymal cell proliferation (GO:0010463)2.77793691
152regulation of centrosome cycle (GO:0046605)2.77446738
153regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.77046669
154cerebral cortex radially oriented cell migration (GO:0021799)2.75982310
155opioid receptor signaling pathway (GO:0038003)2.75864217
156positive regulation of hair follicle development (GO:0051798)2.75483690
157positive regulation of hair cycle (GO:0042635)2.75483690
158indole-containing compound metabolic process (GO:0042430)2.74934769
159organelle transport along microtubule (GO:0072384)2.74682297
160positive regulation of striated muscle tissue development (GO:0045844)2.74411877
161positive regulation of muscle organ development (GO:0048636)2.74411877
162heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.74307513
163regulation of respiratory system process (GO:0044065)2.73956540
164maternal placenta development (GO:0001893)2.73247288
165positive regulation of synaptic transmission, GABAergic (GO:0032230)2.73230696
166positive regulation of SMAD protein import into nucleus (GO:0060391)2.72690322
167positive regulation of gastrulation (GO:2000543)2.72070977
168positive regulation of cardiac muscle tissue development (GO:0055025)2.71045992
169positive regulation of muscle tissue development (GO:1901863)2.68573605
170protein complex localization (GO:0031503)2.68003061
171cardiac epithelial to mesenchymal transition (GO:0060317)2.67032948
172embryonic camera-type eye development (GO:0031076)2.66684807
173regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.66337540
174DNA replication-dependent nucleosome assembly (GO:0006335)2.66135966
175DNA replication-dependent nucleosome organization (GO:0034723)2.66135966
176regulation of cardiac muscle cell proliferation (GO:0060043)2.66010420
177somite rostral/caudal axis specification (GO:0032525)2.65560118
178proteasome assembly (GO:0043248)2.63032301
179establishment of chromosome localization (GO:0051303)2.63032285
180cell differentiation involved in embryonic placenta development (GO:0060706)2.62063538
181regulation of centrosome duplication (GO:0010824)2.61752837
182mitotic sister chromatid segregation (GO:0000070)2.61262039
183pre-miRNA processing (GO:0031054)2.59475854
184establishment of integrated proviral latency (GO:0075713)2.58551505
185regulation of gastrulation (GO:0010470)2.57040966
186DNA catabolic process, exonucleolytic (GO:0000738)2.56868996
187mitotic G2/M transition checkpoint (GO:0044818)2.54579733
188double-strand break repair via nonhomologous end joining (GO:0006303)2.54506264
189non-recombinational repair (GO:0000726)2.54506264
190positive regulation of heart growth (GO:0060421)2.54499162
191axis specification (GO:0009798)2.53724692
192regulation of coenzyme metabolic process (GO:0051196)2.53174383
193regulation of cofactor metabolic process (GO:0051193)2.53174383
194cellular protein complex localization (GO:0034629)2.50945751
195regulation of cell fate specification (GO:0042659)2.50751848
196sister chromatid segregation (GO:0000819)2.50596477

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.40937112
2E2F7_22180533_ChIP-Seq_HELA_Human5.93790579
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.33533077
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.35136435
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.25598546
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.13464601
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.13464601
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.13464601
9TAF15_26573619_Chip-Seq_HEK293_Human3.03595344
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.01046058
11* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96509793
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.90707890
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.89416339
14ESR1_15608294_ChIP-ChIP_MCF-7_Human2.88298517
15AR_21909140_ChIP-Seq_LNCAP_Human2.87307228
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.86830861
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.73051849
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.68614655
19* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.61429063
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.59893710
21ESR1_20079471_ChIP-ChIP_T-47D_Human2.59280362
22CBX2_27304074_Chip-Seq_ESCs_Mouse2.57911753
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.53871225
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.53542657
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.52317845
26JARID2_20075857_ChIP-Seq_MESCs_Mouse2.52308997
27RNF2_27304074_Chip-Seq_NSC_Mouse2.50440338
28* ESR1_21235772_ChIP-Seq_MCF-7_Human2.48065356
29* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44364125
30* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43823462
31SALL1_21062744_ChIP-ChIP_HESCs_Human2.40211986
32EED_16625203_ChIP-ChIP_MESCs_Mouse2.35177569
33REST_21632747_ChIP-Seq_MESCs_Mouse2.31238260
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.30488323
35GBX2_23144817_ChIP-Seq_PC3_Human2.29824934
36RBPJ_22232070_ChIP-Seq_NCS_Mouse2.29403869
37ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27013631
38MYC_18555785_ChIP-Seq_MESCs_Mouse2.25445883
39* EZH2_27294783_Chip-Seq_ESCs_Mouse2.24545284
40CTBP1_25329375_ChIP-Seq_LNCAP_Human2.21632012
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.18707278
42* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12263592
43* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12263592
44PADI4_21655091_ChIP-ChIP_MCF-7_Human2.11020452
45* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09468470
46SMAD3_21741376_ChIP-Seq_HESCs_Human2.05629280
47REST_18959480_ChIP-ChIP_MESCs_Mouse2.04609732
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.00306737
49CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00061192
50NANOG_16153702_ChIP-ChIP_HESCs_Human1.99408548
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.92133652
52ZNF274_21170338_ChIP-Seq_K562_Hela1.89177927
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89091620
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.88633034
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.81104481
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.78864654
57ZNF263_19887448_ChIP-Seq_K562_Human1.78794091
58* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.78169718
59P300_19829295_ChIP-Seq_ESCs_Human1.76569477
60MYC_19030024_ChIP-ChIP_MESCs_Mouse1.75484598
61MYC_19079543_ChIP-ChIP_MESCs_Mouse1.75471155
62CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74633327
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.73141128
64EST1_17652178_ChIP-ChIP_JURKAT_Human1.70834072
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69573908
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.67449175
67EOMES_21245162_ChIP-Seq_HESCs_Human1.67366874
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.65748599
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63115092
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58667367
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.57505868
72* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57159683
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.57154857
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.55105094
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55009470
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.54908254
77IGF1R_20145208_ChIP-Seq_DFB_Human1.53412634
78TCF3_18692474_ChIP-Seq_MEFs_Mouse1.52855119
79SMAD4_21741376_ChIP-Seq_HESCs_Human1.52457131
80AR_21572438_ChIP-Seq_LNCaP_Human1.51425994
81NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.51273334
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.51258437
83MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49343976
84DROSHA_22980978_ChIP-Seq_HELA_Human1.48524224
85* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.47786845
86CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47371537
87* ESR2_21235772_ChIP-Seq_MCF-7_Human1.46127789
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45836862
89VDR_22108803_ChIP-Seq_LS180_Human1.45521206
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43732438
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.43099623
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.40936123
93ELK1_19687146_ChIP-ChIP_HELA_Human1.38717780
94E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38303444
95RING1B_27294783_Chip-Seq_NPCs_Mouse1.37072242
96* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35523913
97* ER_23166858_ChIP-Seq_MCF-7_Human1.34353522
98ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34236535
99TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33898228
100ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33476800
101TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33401519
102MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33064132
103DCP1A_22483619_ChIP-Seq_HELA_Human1.30817522
104JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.29166813
105SOX2_16153702_ChIP-ChIP_HESCs_Human1.28092681
106NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27916009
107SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.27527992
108MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26936204
109TCF3_18692474_ChIP-Seq_MESCs_Mouse1.25667299
110IRF1_19129219_ChIP-ChIP_H3396_Human1.24834031
111RARB_27405468_Chip-Seq_BRAIN_Mouse1.24513827
112POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23083927
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22746408
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22746408
115GATA1_22025678_ChIP-Seq_K562_Human1.22639325
116SOX17_20123909_ChIP-Seq_XEN_Mouse1.22220244
117TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22138784
118SMAD3_21741376_ChIP-Seq_ESCs_Human1.20365473
119YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20345766
120SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19655939
121NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19200817
122DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19119090
123* SOX2_21211035_ChIP-Seq_LN229_Gbm1.18680609
124AR_19668381_ChIP-Seq_PC3_Human1.18122850
125STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17951779
126RUNX2_22187159_ChIP-Seq_PCA_Human1.17423731
127BCAT_22108803_ChIP-Seq_LS180_Human1.17202951
128SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17192320
129PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16493114
130FLI1_27457419_Chip-Seq_LIVER_Mouse1.16382914
131EWS_26573619_Chip-Seq_HEK293_Human1.15782087
132IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14906111
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14240954
134* GATA3_24758297_ChIP-Seq_MCF-7_Human1.14198741
135POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14027915
136* SMAD4_21741376_ChIP-Seq_EPCs_Human1.13193188
137* SMAD3_21741376_ChIP-Seq_EPCs_Human1.12403768
138* KDM2B_26808549_Chip-Seq_REH_Human1.11459256
139VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10433617
140NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.09560688
141P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08845659
142ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08330211
143PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08257046
144TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08227034
145CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.07927872
146FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06504304
147GATA1_26923725_Chip-Seq_HPCs_Mouse1.05408804
148ETS1_20019798_ChIP-Seq_JURKAT_Human1.04747466
149EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04239257
150NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03884860
151AHR_22903824_ChIP-Seq_MCF-7_Human1.03076276
152TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02695587
153TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02402075
154WT1_19549856_ChIP-ChIP_CCG9911_Human1.02176395
155PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02154041
156CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01694828
157FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01332469
158PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00881737
159SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99431990
160NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99178575
161YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97695576
162ERG_21242973_ChIP-ChIP_JURKAT_Human0.97618490
163FUS_26573619_Chip-Seq_HEK293_Human0.97090402
164ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97054431
165TP53_20018659_ChIP-ChIP_R1E_Mouse0.96602911
166* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96088008
167THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94921037
168EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94066210
169TCF4_23295773_ChIP-Seq_U87_Human0.93956200
170* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93170523
171* STAT3_23295773_ChIP-Seq_U87_Human0.92468597
172NANOG_21062744_ChIP-ChIP_HESCs_Human0.91737860
173ARNT_22903824_ChIP-Seq_MCF-7_Human0.91582117
174POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.90658785
175EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.89259520
176CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88038963
177DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88016409
178GABP_19822575_ChIP-Seq_HepG2_Human0.87950803
179FOXP3_21729870_ChIP-Seq_TREG_Human0.87600567
180MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87402731
181SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.86822623
182TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86808759
183KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86726571
184KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.85789142
185TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.85532531
186TP53_18474530_ChIP-ChIP_U2OS_Human0.84625278
187JUN_21703547_ChIP-Seq_K562_Human0.83993806
188SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83781044
189* SMAD4_21799915_ChIP-Seq_A2780_Human0.82912929
190ZFP281_18757296_ChIP-ChIP_E14_Mouse0.81111403
191PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.80533767

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting8.78041943
2MP0001529_abnormal_vocalization4.78281249
3MP0006276_abnormal_autonomic_nervous4.75398887
4MP0003121_genomic_imprinting4.67492440
5MP0005645_abnormal_hypothalamus_physiol4.59812720
6MP0010030_abnormal_orbit_morphology3.88938868
7MP0008995_early_reproductive_senescence3.43551068
8MP0003959_abnormal_lean_body2.80536667
9MP0003119_abnormal_digestive_system2.77594724
10MP0004859_abnormal_synaptic_plasticity2.55288914
11MP0004957_abnormal_blastocyst_morpholog2.48750113
12MP0004133_heterotaxia2.48231807
13MP0003718_maternal_effect2.44585822
14MP0003693_abnormal_embryo_hatching2.42050213
15MP0003941_abnormal_skin_development2.37346724
16MP0008057_abnormal_DNA_replication2.35863230
17MP0000778_abnormal_nervous_system2.35781652
18MP0003635_abnormal_synaptic_transmissio2.32585465
19MP0010094_abnormal_chromosome_stability2.30141282
20MP0003880_abnormal_central_pattern2.30092802
21MP0008961_abnormal_basal_metabolism2.25355538
22MP0002254_reproductive_system_inflammat2.20494678
23MP0005535_abnormal_body_temperature2.20468505
24MP0003283_abnormal_digestive_organ2.16435939
25MP0001501_abnormal_sleep_pattern2.15980239
26MP0004264_abnormal_extraembryonic_tissu2.14418033
27MP0003937_abnormal_limbs/digits/tail_de2.13784922
28MP0004270_analgesia2.13265313
29MP0001984_abnormal_olfaction2.10792695
30MP0008932_abnormal_embryonic_tissue2.03820785
31MP0001968_abnormal_touch/_nociception1.96945184
32MP0001440_abnormal_grooming_behavior1.83855072
33MP0002736_abnormal_nociception_after1.81339335
34MP0002063_abnormal_learning/memory/cond1.81335784
35MP0001672_abnormal_embryogenesis/_devel1.79230615
36MP0005380_embryogenesis_phenotype1.79230615
37MP0009745_abnormal_behavioral_response1.78910306
38MP0002557_abnormal_social/conspecific_i1.78554853
39MP0001502_abnormal_circadian_rhythm1.75987901
40MP0003195_calcinosis1.75296462
41MP0009672_abnormal_birth_weight1.74322342
42MP0002084_abnormal_developmental_patter1.71756783
43MP0002733_abnormal_thermal_nociception1.71614516
44MP0002572_abnormal_emotion/affect_behav1.70007600
45MP0002909_abnormal_adrenal_gland1.68921692
46MP0000383_abnormal_hair_follicle1.67753659
47MP0002064_seizures1.67729665
48MP0005646_abnormal_pituitary_gland1.66382884
49MP0005394_taste/olfaction_phenotype1.62839053
50MP0005499_abnormal_olfactory_system1.62839053
51MP0003123_paternal_imprinting1.61268408
52MP0001486_abnormal_startle_reflex1.60566858
53MP0002272_abnormal_nervous_system1.59022675
54MP0002184_abnormal_innervation1.57684052
55MP0008058_abnormal_DNA_repair1.52585891
56MP0000537_abnormal_urethra_morphology1.50926940
57MP0003984_embryonic_growth_retardation1.50508605
58MP0001293_anophthalmia1.50090736
59MP0003077_abnormal_cell_cycle1.49054955
60MP0002085_abnormal_embryonic_tissue1.48689873
61MP0002088_abnormal_embryonic_growth/wei1.48441152
62MP0002638_abnormal_pupillary_reflex1.46798572
63MP0000538_abnormal_urinary_bladder1.43033694
64MP0000751_myopathy1.40137869
65MP0004233_abnormal_muscle_weight1.38586848
66MP0004924_abnormal_behavior1.35635865
67MP0005386_behavior/neurological_phenoty1.35635865
68MP0002111_abnormal_tail_morphology1.35612627
69MP0004381_abnormal_hair_follicle1.35502488
70MP0009046_muscle_twitch1.35072327
71MP0000428_abnormal_craniofacial_morphol1.34256635
72MP0005257_abnormal_intraocular_pressure1.34071803
73MP0010678_abnormal_skin_adnexa1.32592865
74MP0002796_impaired_skin_barrier1.29104379
75MP0009384_cardiac_valve_regurgitation1.28658087
76MP0009053_abnormal_anal_canal1.27769061
77MP0002139_abnormal_hepatobiliary_system1.26168231
78MP0001730_embryonic_growth_arrest1.25643503
79MP0005076_abnormal_cell_differentiation1.25518938
80MP0001697_abnormal_embryo_size1.24201828
81MP0002734_abnormal_mechanical_nocicepti1.23660943
82MP0002233_abnormal_nose_morphology1.23293874
83MP0003111_abnormal_nucleus_morphology1.23131825
84MP0002127_abnormal_cardiovascular_syste1.23082378
85MP0002067_abnormal_sensory_capabilities1.22876673
86MP0003948_abnormal_gas_homeostasis1.18714059
87MP0000955_abnormal_spinal_cord1.17365639
88MP0005423_abnormal_somatic_nervous1.16224988
89MP0002697_abnormal_eye_size1.16042019
90MP0008004_abnormal_stomach_pH1.15799026
91MP0000372_irregular_coat_pigmentation1.15760850
92MP0009703_decreased_birth_body1.15090658
93MP0001970_abnormal_pain_threshold1.12897012
94MP0003221_abnormal_cardiomyocyte_apopto1.11816971
95MP0002882_abnormal_neuron_morphology1.10667277
96MP0002066_abnormal_motor_capabilities/c1.10215120
97MP0003935_abnormal_craniofacial_develop1.09875230
98MP0004084_abnormal_cardiac_muscle1.08225211
99MP0002932_abnormal_joint_morphology1.08158585
100MP0000579_abnormal_nail_morphology1.07804271
101MP0001286_abnormal_eye_development1.07035139
102MP0003136_yellow_coat_color1.06955869
103MP0001849_ear_inflammation1.05192669
104MP0005452_abnormal_adipose_tissue1.03922788
105MP0004142_abnormal_muscle_tone1.03769993
106MP0002069_abnormal_eating/drinking_beha1.02600404
107MP0003567_abnormal_fetal_cardiomyocyte1.01791545
108MP0004185_abnormal_adipocyte_glucose1.01442247
109MP0001727_abnormal_embryo_implantation0.98947686
110MP0000462_abnormal_digestive_system0.98780115
111* MP0002080_prenatal_lethality0.98744718
112MP0004197_abnormal_fetal_growth/weight/0.95888187
113MP0002086_abnormal_extraembryonic_tissu0.95403976
114MP0008569_lethality_at_weaning0.94792757
115MP0002735_abnormal_chemical_nociception0.94257910
116MP0000627_abnormal_mammary_gland0.94136795
117MP0002152_abnormal_brain_morphology0.93247294
118MP0003329_amyloid_beta_deposits0.92613970
119MP0002751_abnormal_autonomic_nervous0.92006358
120MP0004215_abnormal_myocardial_fiber0.91746837
121MP0001881_abnormal_mammary_gland0.91149170
122MP0000631_abnormal_neuroendocrine_gland0.90753576
123MP0010630_abnormal_cardiac_muscle0.90748368
124MP0001177_atelectasis0.90003132
125MP0009250_abnormal_appendicular_skeleto0.89962891
126MP0003890_abnormal_embryonic-extraembry0.87236339
127MP0003690_abnormal_glial_cell0.86524643
128MP0000762_abnormal_tongue_morphology0.85737485
129MP0003137_abnormal_impulse_conducting0.84878497
130MP0000026_abnormal_inner_ear0.84571644
131MP0000350_abnormal_cell_proliferation0.84016999
132MP0003943_abnormal_hepatobiliary_system0.83360487
133MP0005330_cardiomyopathy0.83136814
134MP0003942_abnormal_urinary_system0.82187594
135MP0005408_hypopigmentation0.81883134
136MP0006072_abnormal_retinal_apoptosis0.81387585
137MP0000566_synostosis0.80420351
138MP0004811_abnormal_neuron_physiology0.80203780
139* MP0003953_abnormal_hormone_level0.79920306
140MP0004085_abnormal_heartbeat0.79659168
141MP0000432_abnormal_head_morphology0.77175112
142MP0005670_abnormal_white_adipose0.76936005
143MP0001905_abnormal_dopamine_level0.75568478
144MP0002752_abnormal_somatic_nervous0.75033524
145MP0002102_abnormal_ear_morphology0.74833885
146MP0003646_muscle_fatigue0.74677094
147MP0004087_abnormal_muscle_fiber0.73875037
148MP0002925_abnormal_cardiovascular_devel0.72802804
149MP0009697_abnormal_copulation0.72753014
150MP0002971_abnormal_brown_adipose0.72710859
151MP0001963_abnormal_hearing_physiology0.71807611
152MP0002970_abnormal_white_adipose0.71708367
153MP0003868_abnormal_feces_composition0.71141107
154MP0002078_abnormal_glucose_homeostasis0.70902798
155MP0005448_abnormal_energy_balance0.70575758
156MP0002282_abnormal_trachea_morphology0.70324542
157MP0003303_peritoneal_inflammation0.68842973
158MP0002092_abnormal_eye_morphology0.68636258
159MP0001943_abnormal_respiration0.67731818
160MP0003566_abnormal_cell_adhesion0.67547441
161* MP0002109_abnormal_limb_morphology0.67449068
162MP0000049_abnormal_middle_ear0.67184667
163MP0003861_abnormal_nervous_system0.66744435
164MP0005620_abnormal_muscle_contractility0.66391732
165MP0003172_abnormal_lysosome_physiology0.66288329
166MP0004130_abnormal_muscle_cell0.62431269
167MP0010770_preweaning_lethality0.59939304
168MP0002082_postnatal_lethality0.59939304
169MP0003936_abnormal_reproductive_system0.59249191
170MP0005360_urolithiasis0.58586235
171MP0005395_other_phenotype0.57275585
172MP0010769_abnormal_survival0.57083460
173MP0010768_mortality/aging0.56255081
174MP0005187_abnormal_penis_morphology0.55093518
175MP0003385_abnormal_body_wall0.54840108
176MP0003956_abnormal_body_size0.53065687
177MP0001299_abnormal_eye_distance/0.52524718
178MP0003183_abnormal_peptide_metabolism0.52289334
179MP0003091_abnormal_cell_migration0.52119594
180MP0000427_abnormal_hair_cycle0.51616839
181MP0005248_abnormal_Harderian_gland0.51607835
182MP0003632_abnormal_nervous_system0.49745017
183MP0004145_abnormal_muscle_electrophysio0.48976095

Predicted human phenotypes

RankGene SetZ-score
1Failure to thrive in infancy (HP:0001531)7.72447670
2Polyphagia (HP:0002591)7.11187360
3Sleep apnea (HP:0010535)5.98343954
4Abnormality of the labia minora (HP:0012880)5.11965751
5Abnormal eating behavior (HP:0100738)5.08291947
6Abnormal hair whorl (HP:0010721)4.03076773
711 pairs of ribs (HP:0000878)4.01655240
8Esotropia (HP:0000565)3.99633105
9Stenosis of the external auditory canal (HP:0000402)3.94356420
10Deep palmar crease (HP:0006191)3.94097223
11Abnormal umbilical cord blood vessels (HP:0011403)3.85576071
12Single umbilical artery (HP:0001195)3.85576071
13Abnormality of the fetal cardiovascular system (HP:0010948)3.85576071
14Narrow nasal bridge (HP:0000446)3.84097184
15Oligomenorrhea (HP:0000876)3.83928903
16Limb dystonia (HP:0002451)3.74732521
17Atonic seizures (HP:0010819)3.70617825
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.45681641
19Abnormal pancreas size (HP:0012094)3.41648507
20Hypoventilation (HP:0002791)3.35479115
21Abnormality of the umbilical cord (HP:0010881)3.35278511
22Concave nail (HP:0001598)3.34587432
23Papilledema (HP:0001085)3.33817964
24Bifid tongue (HP:0010297)3.32356522
25Birth length less than 3rd percentile (HP:0003561)3.31872748
26Shoulder girdle muscle weakness (HP:0003547)3.31641611
27Fair hair (HP:0002286)3.22817188
28Abnormality of glycosphingolipid metabolism (HP:0004343)3.21191586
29Abnormality of glycolipid metabolism (HP:0010969)3.21191586
30Abnormality of liposaccharide metabolism (HP:0010968)3.21191586
31Open mouth (HP:0000194)3.21165910
32Labial hypoplasia (HP:0000066)3.20922731
33Double outlet right ventricle (HP:0001719)3.19172159
34Congenital malformation of the right heart (HP:0011723)3.19172159
35Mild short stature (HP:0003502)3.17949768
36Absent speech (HP:0001344)3.09732204
37Abdominal situs inversus (HP:0003363)3.08891492
38Abnormality of abdominal situs (HP:0011620)3.08891492
39Microglossia (HP:0000171)3.08204683
40Aplasia/hypoplasia of the humerus (HP:0006507)3.06106237
41Chromsome breakage (HP:0040012)3.02675072
42Postural tremor (HP:0002174)3.00457831
43Poor suck (HP:0002033)3.00298984
44Blue irides (HP:0000635)2.93444008
45Abnormality of the hip-girdle musculature (HP:0001445)2.91955735
46Abnormality of the musculature of the pelvis (HP:0001469)2.91955735
47Short humerus (HP:0005792)2.90371305
48Short middle phalanx of the 5th finger (HP:0004220)2.89928929
49Metaphyseal cupping (HP:0003021)2.88931412
50Missing ribs (HP:0000921)2.87937386
51Myelomeningocele (HP:0002475)2.85952671
52Supranuclear gaze palsy (HP:0000605)2.84579932
53Absent radius (HP:0003974)2.81979247
54Hypoplastic female external genitalia (HP:0012815)2.81930063
55Macroorchidism (HP:0000053)2.78677281
56Aplasia/Hypoplasia of the uvula (HP:0010293)2.78099119
57Abnormality of the septum pellucidum (HP:0007375)2.75573125
58Decreased muscle mass (HP:0003199)2.75481591
59Embryonal renal neoplasm (HP:0011794)2.75202684
60Pelvic girdle muscle weakness (HP:0003749)2.74655368
61Aplasia involving forearm bones (HP:0009822)2.73620583
62Absent forearm bone (HP:0003953)2.73620583
63Micronodular cirrhosis (HP:0001413)2.73612595
64Facial cleft (HP:0002006)2.73056982
65Absence seizures (HP:0002121)2.72112588
66Severe muscular hypotonia (HP:0006829)2.71629913
67Aplasia/Hypoplasia of the sacrum (HP:0008517)2.69565494
68Anal stenosis (HP:0002025)2.69391498
69Absent septum pellucidum (HP:0001331)2.69212314
70Abnormality of mucopolysaccharide metabolism (HP:0011020)2.68928330
71Abnormality of polysaccharide metabolism (HP:0011012)2.68928330
72Abnormality of glycosaminoglycan metabolism (HP:0004371)2.68928330
73Agitation (HP:0000713)2.68420871
74Acute hepatic failure (HP:0006554)2.65319430
75Oligodactyly (hands) (HP:0001180)2.62625954
76Dysphonia (HP:0001618)2.62466479
77Abnormal lung lobation (HP:0002101)2.55397119
78Generalized hypotonia (HP:0001290)2.54250395
79Excessive salivation (HP:0003781)2.53499591
80Drooling (HP:0002307)2.53499591
81Decreased electroretinogram (ERG) amplitude (HP:0000654)2.50812668
82Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.50684574
83Septo-optic dysplasia (HP:0100842)2.49983211
84Thyroid-stimulating hormone excess (HP:0002925)2.49115895
85Meckel diverticulum (HP:0002245)2.48430724
86Myokymia (HP:0002411)2.47077498
87Asymmetric growth (HP:0100555)2.43936656
88Bell-shaped thorax (HP:0001591)2.43452913
89Akinesia (HP:0002304)2.42804635
90Craniofacial dystonia (HP:0012179)2.38732817
91Abnormality of chromosome stability (HP:0003220)2.35843264
92Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.35207572
93Myopathic facies (HP:0002058)2.34032904
94Anteriorly placed anus (HP:0001545)2.33359036
95Preaxial foot polydactyly (HP:0001841)2.32985903
96Generalized hypopigmentation of hair (HP:0011358)2.31792824
97Torticollis (HP:0000473)2.29627184
98Progressive inability to walk (HP:0002505)2.28630949
99Abnormality of the ileum (HP:0001549)2.27720649
100Growth hormone deficiency (HP:0000824)2.26235974
101Ankle clonus (HP:0011448)2.25674375
102Focal dystonia (HP:0004373)2.25300968
103Diastasis recti (HP:0001540)2.25158430
104Choroideremia (HP:0001139)2.23950904
105Nephroblastoma (Wilms tumor) (HP:0002667)2.22928974
106Split foot (HP:0001839)2.21136336
107Abnormalities of placenta or umbilical cord (HP:0001194)2.20867442
108Breast carcinoma (HP:0003002)2.20369646
109Abnormality of the preputium (HP:0100587)2.20266997
110Narrow forehead (HP:0000341)2.19209005
111Hypoplastic labia majora (HP:0000059)2.16166945
112Lissencephaly (HP:0001339)2.15758808
113Fused cervical vertebrae (HP:0002949)2.15484483
114Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.15364918
115Fetal akinesia sequence (HP:0001989)2.15035682
116Limb-girdle muscle atrophy (HP:0003797)2.09769852
117Abnormality of the labia majora (HP:0012881)2.09721616
118Abnormality of the clitoris (HP:0000056)2.09534773
119Visual hallucinations (HP:0002367)2.08206007
120Menstrual irregularities (HP:0000858)2.08036562
121Transposition of the great arteries (HP:0001669)2.07847680
122Abnormal connection of the cardiac segments (HP:0011545)2.07847680
123Abnormal ventriculo-arterial connection (HP:0011563)2.07847680
124Dialeptic seizures (HP:0011146)2.07709515
125Hypobetalipoproteinemia (HP:0003563)2.05949999
126Ectopic anus (HP:0004397)2.05897688
127Aplasia/Hypoplasia involving the musculature (HP:0001460)2.05739798
128Aplasia/Hypoplasia of the clavicles (HP:0006710)2.05377273
129Spinal canal stenosis (HP:0003416)2.04889919
130Abnormality of the pubic bones (HP:0003172)2.04751265
131Abnormality of the phalanges of the 5th finger (HP:0004213)2.04621748
132Focal seizures (HP:0007359)2.03860501
133Hip dysplasia (HP:0001385)2.00417076
134Abnormality of the parathyroid morphology (HP:0011766)2.00074314
135Short hallux (HP:0010109)1.99067370
136Colon cancer (HP:0003003)1.98901027
137Abnormality of the labia (HP:0000058)1.98775038
138Anophthalmia (HP:0000528)1.97577063
139Anal atresia (HP:0002023)1.96808190
140Protruding tongue (HP:0010808)1.96381962
141Abnormal vertebral ossification (HP:0100569)1.93840830
142Deviation of the thumb (HP:0009603)1.92915095
143Status epilepticus (HP:0002133)1.92381008
144Lower limb asymmetry (HP:0100559)1.91624104
145Short clavicles (HP:0000894)1.91543006
146Proximal tubulopathy (HP:0000114)1.90935558
147Right ventricular cardiomyopathy (HP:0011663)1.90048968
148Proximal placement of thumb (HP:0009623)1.89631960
149Hypothermia (HP:0002045)1.88818825
150Abnormality of aromatic amino acid family metabolism (HP:0004338)1.88253166
151Abnormality of the corticospinal tract (HP:0002492)1.88199556
152Hepatoblastoma (HP:0002884)1.87167806
153Impaired pain sensation (HP:0007328)1.86280017
154Abnormality of pain sensation (HP:0010832)1.86280017
155Oligodontia (HP:0000677)1.86025569
156Psychosis (HP:0000709)1.86013409
157Hypoplastic pelvis (HP:0008839)1.85976511
158Epileptic encephalopathy (HP:0200134)1.85696301
159Hyperalaninemia (HP:0003348)1.84831044
160Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84831044
161Abnormality of alanine metabolism (HP:0010916)1.84831044
162Ependymoma (HP:0002888)1.84357531
163Triphalangeal thumb (HP:0001199)1.84152311
164Hypogonadotrophic hypogonadism (HP:0000044)1.83578547
165Preauricular pit (HP:0004467)1.83372596
166Periauricular skin pits (HP:0100277)1.83372596
167Abnormality of the duodenum (HP:0002246)1.82942187
168Medulloblastoma (HP:0002885)1.82789586
169Delayed myelination (HP:0012448)1.82596956
170Oligodactyly (HP:0012165)1.82335437
171Vaginal atresia (HP:0000148)1.82304097
172Depression (HP:0000716)1.82024314
173Shawl scrotum (HP:0000049)1.80773854
174Gonadotropin excess (HP:0000837)1.80618639
175Asymmetry of the thorax (HP:0001555)1.77430787
176Choanal stenosis (HP:0000452)1.74555597
177Small intestinal stenosis (HP:0012848)1.73188320
178Duodenal stenosis (HP:0100867)1.73188320
179Tracheal stenosis (HP:0002777)1.72674801
180Rectal fistula (HP:0100590)1.72109260
181Rectovaginal fistula (HP:0000143)1.72109260
182Abnormality of cochlea (HP:0000375)1.71546352
183Genital tract atresia (HP:0001827)1.70814319
184Aplasia/Hypoplasia of the hallux (HP:0008362)1.70462614
185Abnormality of the aortic arch (HP:0012303)1.69506556
186Bilateral microphthalmos (HP:0007633)1.68848190
187Rhabdomyosarcoma (HP:0002859)1.67739583
188Ovarian neoplasm (HP:0100615)1.67616891
189Short middle phalanx of finger (HP:0005819)1.66840242
190Distal arthrogryposis (HP:0005684)1.62278969
191Absent frontal sinuses (HP:0002688)1.60728738
192Patellar aplasia (HP:0006443)1.60402897

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.83130165
2VRK14.65445800
3ERBB44.51338877
4MARK13.74173719
5PBK3.41475690
6BCR3.36793630
7PLK43.01059204
8ACVR1B2.97928625
9PDK22.93713396
10TSSK62.86551864
11TRIM282.71926560
12IRAK22.60431629
13DDR22.59870577
14SIK32.54774360
15TAOK22.48030221
16TTK2.47112450
17WEE12.39072568
18CSNK1G32.36150520
19SRPK12.33107518
20MKNK22.26321600
21UHMK12.24362263
22NTRK32.23212735
23CSNK1G22.11966029
24PRPF4B2.11723693
25CAMK1D2.11015005
26EIF2AK32.09776949
27IRAK42.07318721
28CASK2.06375304
29BMPR1B2.00879371
30KSR11.97046343
31PIK3CA1.91713170
32TYRO31.88329167
33MINK11.83693541
34ERN11.83113162
35NTRK21.80081857
36TAF11.78560054
37LATS21.76630965
38MUSK1.73798249
39BUB11.72242936
40NEK11.71510132
41MST41.70078410
42CSNK1G11.65387778
43MAP2K71.61031627
44CAMK1G1.60750946
45MAP3K41.59693097
46EPHB21.58142647
47IRAK11.55635846
48STK38L1.55614787
49PDGFRA1.51244452
50PLK31.49565334
51SIK21.48626960
52BRSK21.47561757
53CSNK1A1L1.46476471
54PKN21.43743694
55MKNK11.41178612
56SIK11.37009906
57MELK1.33586579
58MAPK131.31813438
59MAP2K41.27549952
60FGR1.26785232
61MATK1.24555499
62RPS6KB21.23415338
63TGFBR11.22116173
64EIF2AK11.21901777
65VRK21.19312970
66CDC71.15674538
67MAP3K121.15589948
68NUAK11.13519523
69EIF2AK21.10189771
70NEK61.08398094
71TIE11.07475529
72CDK181.07216696
73PLK11.05938628
74TNIK1.04849986
75CDK191.02653918
76PAK40.97470053
77STK380.96871912
78BRAF0.94497997
79PAK30.92955662
80CDK150.92237428
81CDK140.89940055
82PAK60.89877187
83FGFR10.86916184
84PHKG10.85100806
85PHKG20.85100806
86EPHA20.83691844
87CDK50.82912464
88NEK20.81529047
89NTRK10.81165706
90ZAK0.81109713
91FGFR20.79464560
92FRK0.79377912
93CDK11A0.78500752
94FES0.74555817
95STK30.73718386
96ERBB30.72316323
97GRK70.71386950
98FER0.70242343
99NME20.69262755
100BRSK10.67922523
101GRK50.67730516
102MAPK90.67166194
103CHEK20.65309780
104PRKCE0.63948500
105ICK0.63078949
106CDK70.62147629
107TRIB30.60434976
108PNCK0.60331565
109CAMK2A0.60073813
110CHUK0.59015545
111MAP3K130.58992309
112WNK30.57792696
113MAP3K100.57237110
114AURKB0.56782977
115OBSCN0.56761846
116DYRK20.56741722
117LATS10.56590609
118OXSR10.54371004
119ABL20.54024581
120ATR0.53773889
121CDC42BPA0.53567347
122PRKACG0.53156924
123CSNK1E0.52508359
124CHEK10.51194033
125STK160.50948546
126NME10.50388879
127DYRK30.50361272
128PLK20.49933107
129MAP3K80.48558319
130PRKCG0.48325238
131DMPK0.47020938
132PRKACA0.44631101
133DYRK1A0.42131514
134CCNB10.42072361
135MAPK40.41219087
136CAMK2B0.41138814
137MAP2K10.41068121
138PRKCZ0.40768703
139SCYL20.39478414
140MAP4K20.39205598
141PRKAA20.37765335
142EGFR0.37699670
143RPS6KA40.37315891
144CLK10.36560181
145MAPK150.36231518
146ALK0.34759341
147RPS6KB10.33966991
148FYN0.33887476
149PRKG10.33196013
150ATM0.33149444
151CSNK1D0.33057196
152LRRK20.32782606
153CDK10.32188507
154PASK0.32100849
155KSR20.32051178
156PKN10.31946886
157INSRR0.31494597
158CSNK2A10.30576086
159PRKCI0.30491550
160MAP2K60.30096591
161TESK10.29678394
162TTN0.29287624
163SMG10.29241865
164EPHA40.28854232
165RPS6KA30.28234206
166ADRBK10.27798949
167MAPK100.27377631
168PRKCB0.27090872
169CAMK10.26967357
170ROCK10.26653909
171MAPK80.25414689
172STK100.25148164
173MARK20.23805331
174PAK20.23564875
175ROCK20.23028667
176SRC0.22573192
177TBK10.20999453

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.75379136
2Cocaine addiction_Homo sapiens_hsa050303.54458314
3Nicotine addiction_Homo sapiens_hsa050333.11553441
4Mismatch repair_Homo sapiens_hsa034302.96098063
5GABAergic synapse_Homo sapiens_hsa047272.81699398
6Amphetamine addiction_Homo sapiens_hsa050312.74199479
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.63255919
8DNA replication_Homo sapiens_hsa030302.52158372
9Morphine addiction_Homo sapiens_hsa050322.40162959
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.38525085
11Non-homologous end-joining_Homo sapiens_hsa034502.38481956
12Dopaminergic synapse_Homo sapiens_hsa047282.33713427
13Insulin secretion_Homo sapiens_hsa049112.30657769
14Axon guidance_Homo sapiens_hsa043602.21426955
15Homologous recombination_Homo sapiens_hsa034402.18588770
16TGF-beta signaling pathway_Homo sapiens_hsa043502.17324777
17RNA transport_Homo sapiens_hsa030132.13226674
18Serotonergic synapse_Homo sapiens_hsa047262.07150933
19Fanconi anemia pathway_Homo sapiens_hsa034602.06991043
20Synaptic vesicle cycle_Homo sapiens_hsa047212.04393830
21Butanoate metabolism_Homo sapiens_hsa006502.04203735
22Cell cycle_Homo sapiens_hsa041102.02146137
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.02125689
24Long-term potentiation_Homo sapiens_hsa047201.96553465
25Circadian entrainment_Homo sapiens_hsa047131.95352788
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.90930895
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90062408
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.87513210
29Steroid biosynthesis_Homo sapiens_hsa001001.86422467
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76679217
31Glutamatergic synapse_Homo sapiens_hsa047241.66888820
32Pyruvate metabolism_Homo sapiens_hsa006201.61180530
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.60386434
34Selenocompound metabolism_Homo sapiens_hsa004501.59020380
35Spliceosome_Homo sapiens_hsa030401.58607764
36Renin-angiotensin system_Homo sapiens_hsa046141.57764429
37Estrogen signaling pathway_Homo sapiens_hsa049151.56874926
38Base excision repair_Homo sapiens_hsa034101.52883813
39Basal transcription factors_Homo sapiens_hsa030221.52538488
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50378216
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48869627
42Thyroid cancer_Homo sapiens_hsa052161.46109105
43Cardiac muscle contraction_Homo sapiens_hsa042601.44218191
44Tight junction_Homo sapiens_hsa045301.43031464
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.43022443
46Olfactory transduction_Homo sapiens_hsa047401.41706577
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38899941
48Gap junction_Homo sapiens_hsa045401.36292930
49Nucleotide excision repair_Homo sapiens_hsa034201.35123153
50Alcoholism_Homo sapiens_hsa050341.33055816
51Protein export_Homo sapiens_hsa030601.32726037
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.32206042
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.29367566
54Thyroid hormone synthesis_Homo sapiens_hsa049181.26746318
55Parkinsons disease_Homo sapiens_hsa050121.25117485
56Tryptophan metabolism_Homo sapiens_hsa003801.25064847
57Prion diseases_Homo sapiens_hsa050201.20683299
58Hedgehog signaling pathway_Homo sapiens_hsa043401.20601000
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19686769
60RNA degradation_Homo sapiens_hsa030181.18242557
61One carbon pool by folate_Homo sapiens_hsa006701.15584230
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13234016
63Central carbon metabolism in cancer_Homo sapiens_hsa052301.12796357
64Nitrogen metabolism_Homo sapiens_hsa009101.12770537
65Phenylalanine metabolism_Homo sapiens_hsa003601.12758974
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.12389814
67Dorso-ventral axis formation_Homo sapiens_hsa043201.11928738
68Carbon metabolism_Homo sapiens_hsa012001.11162040
69Taste transduction_Homo sapiens_hsa047421.09642427
70* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09106182
71Wnt signaling pathway_Homo sapiens_hsa043101.06493023
72Sulfur metabolism_Homo sapiens_hsa009201.05855463
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05701131
74N-Glycan biosynthesis_Homo sapiens_hsa005101.05584843
75Melanogenesis_Homo sapiens_hsa049161.05331773
76Biosynthesis of amino acids_Homo sapiens_hsa012301.05314969
77Sulfur relay system_Homo sapiens_hsa041221.05196988
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03552074
79Oxidative phosphorylation_Homo sapiens_hsa001901.03143631
80Oxytocin signaling pathway_Homo sapiens_hsa049211.02250828
81Long-term depression_Homo sapiens_hsa047301.02112186
82Oocyte meiosis_Homo sapiens_hsa041141.00957167
83Adherens junction_Homo sapiens_hsa045200.99556917
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97572300
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97331591
86Renin secretion_Homo sapiens_hsa049240.95536375
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95009206
88ErbB signaling pathway_Homo sapiens_hsa040120.94914423
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92016555
90MAPK signaling pathway_Homo sapiens_hsa040100.91713745
91mRNA surveillance pathway_Homo sapiens_hsa030150.90674390
92Basal cell carcinoma_Homo sapiens_hsa052170.89280761
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88893483
94Arginine biosynthesis_Homo sapiens_hsa002200.88601363
95GnRH signaling pathway_Homo sapiens_hsa049120.88318734
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86175802
97Cholinergic synapse_Homo sapiens_hsa047250.85829373
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85139380
99RNA polymerase_Homo sapiens_hsa030200.83688826
100Salivary secretion_Homo sapiens_hsa049700.83531508
101Dilated cardiomyopathy_Homo sapiens_hsa054140.82771511
102Proteoglycans in cancer_Homo sapiens_hsa052050.80315960
103Collecting duct acid secretion_Homo sapiens_hsa049660.79131177
104Gastric acid secretion_Homo sapiens_hsa049710.78764901
105Vibrio cholerae infection_Homo sapiens_hsa051100.77864822
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.75941290
107Alzheimers disease_Homo sapiens_hsa050100.75057630
108Renal cell carcinoma_Homo sapiens_hsa052110.74335709
109Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73035912
110Fatty acid biosynthesis_Homo sapiens_hsa000610.71479938
111Fatty acid metabolism_Homo sapiens_hsa012120.70020147
112Endometrial cancer_Homo sapiens_hsa052130.69275369
113Glutathione metabolism_Homo sapiens_hsa004800.68937508
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67058474
115cAMP signaling pathway_Homo sapiens_hsa040240.64050483
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62207682
117Melanoma_Homo sapiens_hsa052180.61268277
118Glucagon signaling pathway_Homo sapiens_hsa049220.60710136
119Calcium signaling pathway_Homo sapiens_hsa040200.58305045
120Huntingtons disease_Homo sapiens_hsa050160.56271113
121p53 signaling pathway_Homo sapiens_hsa041150.55894267
122Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55304368
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53561628
124Purine metabolism_Homo sapiens_hsa002300.53090874
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.52919619
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.52880721
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50609047
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49905830
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48684619
130Histidine metabolism_Homo sapiens_hsa003400.47607805
131Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47462917
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47137561
133Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46016124
134Pyrimidine metabolism_Homo sapiens_hsa002400.45382738
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45162501
136Fat digestion and absorption_Homo sapiens_hsa049750.44405589
137Prostate cancer_Homo sapiens_hsa052150.43047120
138ECM-receptor interaction_Homo sapiens_hsa045120.42703525
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42119800
140Propanoate metabolism_Homo sapiens_hsa006400.41787030
141Glycosaminoglycan degradation_Homo sapiens_hsa005310.40730581
142Tyrosine metabolism_Homo sapiens_hsa003500.39989129
143Ras signaling pathway_Homo sapiens_hsa040140.39676371
144Hippo signaling pathway_Homo sapiens_hsa043900.39269064
145Shigellosis_Homo sapiens_hsa051310.38812839
146Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37840286
147Pathways in cancer_Homo sapiens_hsa052000.37625813
148Folate biosynthesis_Homo sapiens_hsa007900.36701486
149Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36140834
150Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34777267
151Arginine and proline metabolism_Homo sapiens_hsa003300.34554729
152Phototransduction_Homo sapiens_hsa047440.33256300
153cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33062247
154Fatty acid degradation_Homo sapiens_hsa000710.31543874
155Metabolic pathways_Homo sapiens_hsa011000.31500541
156Protein digestion and absorption_Homo sapiens_hsa049740.30815295
157Glioma_Homo sapiens_hsa052140.30418804
158Colorectal cancer_Homo sapiens_hsa052100.30167800
159Insulin signaling pathway_Homo sapiens_hsa049100.30093992
160beta-Alanine metabolism_Homo sapiens_hsa004100.29863600
161Type II diabetes mellitus_Homo sapiens_hsa049300.29748322
162Fatty acid elongation_Homo sapiens_hsa000620.28925142
163Bile secretion_Homo sapiens_hsa049760.28357802
164MicroRNAs in cancer_Homo sapiens_hsa052060.27216316
165Insulin resistance_Homo sapiens_hsa049310.24789909

Most similar genes based on co-expression Upload to Enrichr

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