CALHM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H2B ubiquitination (GO:0033523)8.97713936
2response to dietary excess (GO:0002021)8.16038553
3notochord development (GO:0030903)7.37967304
4opioid receptor signaling pathway (GO:0038003)7.23266715
5inner ear receptor cell development (GO:0060119)6.97968617
6detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)5.97006962
7autophagic vacuole fusion (GO:0000046)5.72683112
8activated T cell proliferation (GO:0050798)5.44503971
9cornea development in camera-type eye (GO:0061303)5.42973631
10respiratory chain complex IV assembly (GO:0008535)5.39741642
11nodal signaling pathway (GO:0038092)5.21658937
12reflex (GO:0060004)5.14565451
13cytochrome complex assembly (GO:0017004)4.75501455
14negative regulation of mast cell activation (GO:0033004)4.66263377
15tooth mineralization (GO:0034505)4.52454862
16positive regulation of myotube differentiation (GO:0010831)4.48824740
17cellular ketone body metabolic process (GO:0046950)4.43010477
18detection of mechanical stimulus involved in sensory perception (GO:0050974)4.42339940
19protein autoprocessing (GO:0016540)4.28686648
20coronary vasculature morphogenesis (GO:0060977)4.27822882
21positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.22730536
22cranial nerve morphogenesis (GO:0021602)4.19997621
23organelle membrane fusion (GO:0090174)4.17298941
24myoblast fusion (GO:0007520)4.12155288
25response to pheromone (GO:0019236)4.09028966
26DNA deamination (GO:0045006)4.07882834
27regulation of secondary heart field cardioblast proliferation (GO:0003266)4.05274981
28regulation of cardioblast proliferation (GO:0003264)4.05274981
29G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.03280281
30ketone body metabolic process (GO:1902224)4.02397709
31glycosylceramide metabolic process (GO:0006677)3.98641024
32regulation of establishment of cell polarity (GO:2000114)3.89404142
33mitochondrial genome maintenance (GO:0000002)3.88651036
34mannosylation (GO:0097502)3.88339310
35positive regulation of fibroblast migration (GO:0010763)3.88176070
36facial nerve structural organization (GO:0021612)3.87954463
37detection of light stimulus involved in sensory perception (GO:0050962)3.86674130
38detection of light stimulus involved in visual perception (GO:0050908)3.86674130
39regulation of keratinocyte differentiation (GO:0045616)3.82592552
40outer ear morphogenesis (GO:0042473)3.75848760
41muscle organ morphogenesis (GO:0048644)3.71143152
42amine catabolic process (GO:0009310)3.71049613
43cellular biogenic amine catabolic process (GO:0042402)3.71049613
44lymph vessel development (GO:0001945)3.70727719
45negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.69529711
46regulation of mitochondrial translation (GO:0070129)3.64729576
47neural tube development (GO:0021915)3.62929642
48syncytium formation by plasma membrane fusion (GO:0000768)3.58187728
49protein complex biogenesis (GO:0070271)3.55717355
50positive regulation of monocyte chemotaxis (GO:0090026)3.51953435
51detection of mechanical stimulus (GO:0050982)3.48906643
52positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.48068975
53negative regulation of heart rate (GO:0010459)3.45927705
54positive regulation of cellular amine metabolic process (GO:0033240)3.41830544
55meiotic chromosome segregation (GO:0045132)3.40459986
56rRNA modification (GO:0000154)3.38452342
57peptidyl-tyrosine autophosphorylation (GO:0038083)3.33785370
58mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.31472585
59mitochondrial respiratory chain complex I assembly (GO:0032981)3.31472585
60NADH dehydrogenase complex assembly (GO:0010257)3.31472585
61arginine catabolic process (GO:0006527)3.28129815
62import into cell (GO:0098657)3.28116405
63epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.26445051
64limb bud formation (GO:0060174)3.26361365
65muscle cell fate commitment (GO:0042693)3.25475291
66negative regulation of telomerase activity (GO:0051974)3.25040188
67regulation of neurotransmitter uptake (GO:0051580)3.23966602
68positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.21767831
69L-fucose catabolic process (GO:0042355)3.21708474
70fucose catabolic process (GO:0019317)3.21708474
71L-fucose metabolic process (GO:0042354)3.21708474
72negative regulation of calcium ion transport into cytosol (GO:0010523)3.20743791
73regulation of cilium movement (GO:0003352)3.20534697
74positive regulation of respiratory burst (GO:0060267)3.14536664
75mitochondrial respiratory chain complex assembly (GO:0033108)3.12606841
76preassembly of GPI anchor in ER membrane (GO:0016254)3.11048910
77syncytium formation (GO:0006949)3.08866821
78purinergic nucleotide receptor signaling pathway (GO:0035590)3.08707328
79indole-containing compound catabolic process (GO:0042436)3.08551436
80indolalkylamine catabolic process (GO:0046218)3.08551436
81tryptophan catabolic process (GO:0006569)3.08551436
82negative regulation of synaptic transmission, GABAergic (GO:0032229)3.07559496
83sulfation (GO:0051923)3.06804345
84negative regulation of transcription regulatory region DNA binding (GO:2000678)3.06715912
85protein targeting to Golgi (GO:0000042)3.05541222
86positive regulation of action potential (GO:0045760)3.04924777
87establishment of protein localization to Golgi (GO:0072600)3.03888667
88platelet dense granule organization (GO:0060155)3.02566693
89positive regulation of circadian rhythm (GO:0042753)3.00654817
90negative regulation of neurotransmitter transport (GO:0051589)3.00220119
91transepithelial transport (GO:0070633)3.00216350
92polyol transport (GO:0015791)2.99767247
93embryonic viscerocranium morphogenesis (GO:0048703)2.99424719
94lateral sprouting from an epithelium (GO:0060601)2.99281230
95G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.99257382
96S-adenosylmethionine metabolic process (GO:0046500)2.97970471
97outflow tract septum morphogenesis (GO:0003148)2.97902138
98secondary metabolite biosynthetic process (GO:0044550)2.97509793
99water-soluble vitamin biosynthetic process (GO:0042364)2.96805819
100regulation of establishment or maintenance of cell polarity (GO:0032878)2.96685121
101cranial nerve structural organization (GO:0021604)2.93502412
102regulation of mesenchymal cell apoptotic process (GO:2001053)2.92973267
103plasma membrane repair (GO:0001778)2.92611420
104rRNA methylation (GO:0031167)2.91865122
105arginine metabolic process (GO:0006525)2.91613255
106low-density lipoprotein particle clearance (GO:0034383)2.91109239
107C-terminal protein lipidation (GO:0006501)2.90581139
108anatomical structure arrangement (GO:0048532)2.88107462
109protein-cofactor linkage (GO:0018065)2.87525475
110lipoprotein metabolic process (GO:0042157)2.86477030
111detection of molecule of bacterial origin (GO:0032490)2.83778443
112leukocyte cell-cell adhesion (GO:0007159)2.81568895
113replication fork processing (GO:0031297)2.81326790
114melanin biosynthetic process (GO:0042438)2.80363116
115megakaryocyte development (GO:0035855)2.79786733
116histone mRNA catabolic process (GO:0071044)2.78490233
117C-terminal protein amino acid modification (GO:0018410)2.78314767
118protein localization to Golgi apparatus (GO:0034067)2.77135402
119regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.76767359
120G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.76740910
121piRNA metabolic process (GO:0034587)2.75223173
122histone monoubiquitination (GO:0010390)2.74272231
123kidney morphogenesis (GO:0060993)2.73838507
124retinal cone cell development (GO:0046549)2.72808033
125pharyngeal system development (GO:0060037)2.72722196
126cytoplasmic sequestering of transcription factor (GO:0042994)2.72308686
127oxidative phosphorylation (GO:0006119)2.72300410
128behavioral response to nicotine (GO:0035095)2.71678802
129mitochondrial calcium ion transport (GO:0006851)2.71128986
130adenosine metabolic process (GO:0046085)2.70376059
131melanin metabolic process (GO:0006582)2.69876333
132antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.69452842
133endocrine hormone secretion (GO:0060986)2.68985842
134metallo-sulfur cluster assembly (GO:0031163)2.68244481
135iron-sulfur cluster assembly (GO:0016226)2.68244481
136cellular response to vitamin (GO:0071295)2.67483187
137regulation of hexokinase activity (GO:1903299)2.66724835
138regulation of glucokinase activity (GO:0033131)2.66724835
139exogenous drug catabolic process (GO:0042738)2.66331337
140RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.63990299
141purinergic receptor signaling pathway (GO:0035587)2.63575247
142retrograde transport, vesicle recycling within Golgi (GO:0000301)2.62135032
143axoneme assembly (GO:0035082)2.61965725
144gamma-aminobutyric acid transport (GO:0015812)2.60757908
145tryptophan metabolic process (GO:0006568)2.60681713
146positive regulation of macrophage cytokine production (GO:0060907)2.59777049
147regulation of glomerular filtration (GO:0003093)2.56342005
148photoreceptor cell maintenance (GO:0045494)2.55318164
149mitochondrial calcium ion homeostasis (GO:0051560)2.53805739
150nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.52654657
151auditory receptor cell stereocilium organization (GO:0060088)2.51785321
152positive regulation of guanylate cyclase activity (GO:0031284)2.51360694
153negative regulation of telomere maintenance (GO:0032205)2.50911802
154regulation of skeletal muscle cell differentiation (GO:2001014)2.50387418
155lipid storage (GO:0019915)2.49278543
156proline transport (GO:0015824)2.47376831
157regulation of monocyte chemotaxis (GO:0090025)2.47137613
158modulation by symbiont of host cellular process (GO:0044068)2.46668829
159cellular response to vitamin D (GO:0071305)2.46477837
160activin receptor signaling pathway (GO:0032924)2.45231524
161transmission of nerve impulse (GO:0019226)2.44479094
162regulation of telomere maintenance via telomerase (GO:0032210)2.43825809
163kynurenine metabolic process (GO:0070189)2.43189141
164regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.42036427
165regulation of mitotic spindle checkpoint (GO:1903504)2.42036427
166positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.39970133
167mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.38480802
168vocalization behavior (GO:0071625)2.37970123
169GPI anchor metabolic process (GO:0006505)2.37352745
170regulation of centriole replication (GO:0046599)2.36870766
171artery smooth muscle contraction (GO:0014824)2.36701460
172positive regulation of lipid storage (GO:0010884)2.36498226
173inositol phosphate catabolic process (GO:0071545)2.34696336
174neuronal action potential (GO:0019228)2.34150755
175negative regulation of insulin secretion (GO:0046676)2.33718011
176negative regulation of lipase activity (GO:0060192)2.33395281
177exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.32990233
178cellular response to ATP (GO:0071318)2.32715111
179drug catabolic process (GO:0042737)2.32322961
180phosphatidylinositol acyl-chain remodeling (GO:0036149)2.30132201
181positive regulation of prostaglandin secretion (GO:0032308)2.30037825
182mast cell activation involved in immune response (GO:0002279)2.29769684
183mast cell degranulation (GO:0043303)2.29769684
184glycerophospholipid catabolic process (GO:0046475)2.29548890
185negative regulation of neurological system process (GO:0031645)2.29227150
186tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.28191710
187RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.28191710
188adult feeding behavior (GO:0008343)2.26737457
189negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.26483833
190nitric oxide mediated signal transduction (GO:0007263)2.22966421
191neuronal action potential propagation (GO:0019227)2.22252062
192estrogen biosynthetic process (GO:0006703)2.20764809
193positive regulation of fatty acid transport (GO:2000193)2.20472451
194regulation of nuclear cell cycle DNA replication (GO:0033262)2.20434080
195C4-dicarboxylate transport (GO:0015740)2.19882303

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.29741030
2ZNF274_21170338_ChIP-Seq_K562_Hela3.73352827
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.62286822
4EZH2_22144423_ChIP-Seq_EOC_Human3.54981052
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.36423073
6GBX2_23144817_ChIP-Seq_PC3_Human3.07157555
7HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.77892079
8VDR_22108803_ChIP-Seq_LS180_Human2.74312723
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.73172992
10IGF1R_20145208_ChIP-Seq_DFB_Human2.70939520
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.52291171
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50039731
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.48317865
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.40059274
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.35126901
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.33904423
17AR_21572438_ChIP-Seq_LNCaP_Human2.26860524
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.22802626
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.18761473
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13470638
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.12968953
22PCGF2_27294783_Chip-Seq_ESCs_Mouse2.07641147
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05108630
24PCGF2_27294783_Chip-Seq_NPCs_Mouse2.03519237
25RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02755166
26EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02755166
27EWS_26573619_Chip-Seq_HEK293_Human1.98392452
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.95154514
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91648360
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.91557077
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.85058536
32TP53_18474530_ChIP-ChIP_U2OS_Human1.83220714
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.82320015
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.79854292
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78597216
36ER_23166858_ChIP-Seq_MCF-7_Human1.77727051
37* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76427559
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76366647
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.75480517
40P300_19829295_ChIP-Seq_ESCs_Human1.73240926
41TP53_22573176_ChIP-Seq_HFKS_Human1.71849403
42FUS_26573619_Chip-Seq_HEK293_Human1.68687651
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68168336
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66733198
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.66397522
46CBP_20019798_ChIP-Seq_JUKART_Human1.66397522
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.65589367
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.65375515
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61842745
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.60734333
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.55129759
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52650179
53* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52325766
54CMYC_18555785_Chip-Seq_ESCs_Mouse1.52226891
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.52161558
56DROSHA_22980978_ChIP-Seq_HELA_Human1.50219256
57BCAT_22108803_ChIP-Seq_LS180_Human1.48825072
58IRF1_19129219_ChIP-ChIP_H3396_Human1.48332183
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.48198899
60P53_22387025_ChIP-Seq_ESCs_Mouse1.47790220
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.46179022
62* KDM2B_26808549_Chip-Seq_REH_Human1.45267262
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43213348
64EST1_17652178_ChIP-ChIP_JURKAT_Human1.42735299
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42292309
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41962552
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41875027
68E2F1_18555785_Chip-Seq_ESCs_Mouse1.41788077
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.41760445
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39911867
71MYC_18940864_ChIP-ChIP_HL60_Human1.39512410
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.39187023
73HTT_18923047_ChIP-ChIP_STHdh_Human1.38522255
74SUZ12_18555785_Chip-Seq_ESCs_Mouse1.37181126
75P53_22127205_ChIP-Seq_FIBROBLAST_Human1.37080360
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36484127
77VDR_23849224_ChIP-Seq_CD4+_Human1.35981519
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35740131
79SRF_21415370_ChIP-Seq_HL-1_Mouse1.35456023
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34927312
81LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34707202
82P300_18555785_Chip-Seq_ESCs_Mouse1.34580335
83SOX2_19829295_ChIP-Seq_ESCs_Human1.32178897
84NANOG_19829295_ChIP-Seq_ESCs_Human1.32178897
85FOXA1_25329375_ChIP-Seq_VCAP_Human1.31994546
86FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31994546
87ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31757357
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31455460
89NMYC_18555785_Chip-Seq_ESCs_Mouse1.29924587
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27909062
91TCF4_23295773_ChIP-Seq_U87_Human1.27678917
92ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26829528
93KAP1_22055183_ChIP-Seq_ESCs_Mouse1.26729178
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24739361
95OCT4_18555785_Chip-Seq_ESCs_Mouse1.24186219
96RUNX1_27457419_Chip-Seq_LIVER_Mouse1.23834113
97STAT3_18555785_Chip-Seq_ESCs_Mouse1.22940714
98SMAD3_21741376_ChIP-Seq_HESCs_Human1.21032852
99SOX2_18555785_Chip-Seq_ESCs_Mouse1.20405026
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19887385
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.19742033
102GATA3_21878914_ChIP-Seq_MCF-7_Human1.19635352
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19152051
104AHR_22903824_ChIP-Seq_MCF-7_Human1.18874334
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18614319
106PU1_27457419_Chip-Seq_LIVER_Mouse1.18528661
107CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17907838
108NCOR_22424771_ChIP-Seq_293T_Human1.17667904
109ESRRB_18555785_Chip-Seq_ESCs_Mouse1.17474270
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16594485
111REST_21632747_ChIP-Seq_MESCs_Mouse1.16433092
112JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15352485
113ARNT_22903824_ChIP-Seq_MCF-7_Human1.15310184
114HOXB7_26014856_ChIP-Seq_BT474_Human1.15211033
115SMAD1_18555785_Chip-Seq_ESCs_Mouse1.15064369
116REST_18959480_ChIP-ChIP_MESCs_Mouse1.14790837
117FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14103783
118EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.13482470
119AR_20517297_ChIP-Seq_VCAP_Human1.13000448
120ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12626762
121PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12324810
122ELK1_19687146_ChIP-ChIP_HELA_Human1.11052710
123TCF4_22108803_ChIP-Seq_LS180_Human1.10485476
124GATA3_26560356_Chip-Seq_TH2_Human1.10385922
125PRDM14_20953172_ChIP-Seq_ESCs_Human1.10306291
126SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09978821
127TAF15_26573619_Chip-Seq_HEK293_Human1.08851515
128TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08452551
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08399090
130POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07588580
131RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07537220
132MYC_19829295_ChIP-Seq_ESCs_Human1.07513749
133* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06537678
134FOXP3_21729870_ChIP-Seq_TREG_Human1.04223244
135KLF4_18555785_Chip-Seq_ESCs_Mouse1.04166936
136RUNX2_22187159_ChIP-Seq_PCA_Human1.03553132
137SMAD4_21799915_ChIP-Seq_A2780_Human1.03442530
138CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03423908
139SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03211542
140ETV1_20927104_ChIP-Seq_GIST48_Human1.03016764
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02907345
142CTCF_18555785_Chip-Seq_ESCs_Mouse1.01648593
143CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01293307
144ZFX_18555785_Chip-Seq_ESCs_Mouse1.01005904
145TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00430879
146TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99397342
147HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99157196
148SMAD4_21741376_ChIP-Seq_EPCs_Human0.98935976
149CRX_20693478_ChIP-Seq_RETINA_Mouse0.98635170
150SMAD3_21741376_ChIP-Seq_EPCs_Human0.98126066
151TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98116128
152ERA_21632823_ChIP-Seq_H3396_Human0.98019019
153AR_25329375_ChIP-Seq_VCAP_Human0.97781459
154RBPJ_21746931_ChIP-Seq_IB4_Human0.96787286
155VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96344254
156EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96308032
157CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95910201
158PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94996194
159KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93572281
160OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92748438
161STAT3_23295773_ChIP-Seq_U87_Human0.92073231
162TP53_20018659_ChIP-ChIP_R1E_Mouse0.91717240

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology8.80191984
2MP0003136_yellow_coat_color5.40510343
3MP0005409_darkened_coat_color4.09836913
4MP0004484_altered_response_of3.37367365
5MP0002234_abnormal_pharynx_morphology3.33653226
6MP0000566_synostosis3.30869771
7MP0008877_abnormal_DNA_methylation2.96151349
8MP0002735_abnormal_chemical_nociception2.92878021
9MP0002132_abnormal_respiratory_system2.88643603
10MP0005451_abnormal_body_composition2.87940889
11MP0005645_abnormal_hypothalamus_physiol2.85493541
12MP0009379_abnormal_foot_pigmentation2.81298165
13MP0008872_abnormal_physiological_respon2.67193507
14MP0004036_abnormal_muscle_relaxation2.60025833
15MP0009780_abnormal_chondrocyte_physiolo2.42500591
16MP0004147_increased_porphyrin_level2.41718090
17MP0000579_abnormal_nail_morphology2.23947417
18MP0001968_abnormal_touch/_nociception2.16932316
19MP0003646_muscle_fatigue2.16465720
20MP0000015_abnormal_ear_pigmentation2.11432851
21MP0005551_abnormal_eye_electrophysiolog2.08082194
22MP0000678_abnormal_parathyroid_gland2.04231784
23MP0002249_abnormal_larynx_morphology2.03794908
24MP0000372_irregular_coat_pigmentation2.01743375
25MP0004510_myositis2.01671044
26MP0002837_dystrophic_cardiac_calcinosis2.01581042
27MP0001727_abnormal_embryo_implantation1.94974229
28MP0001661_extended_life_span1.93792028
29MP0002254_reproductive_system_inflammat1.92718391
30MP0001346_abnormal_lacrimal_gland1.89821862
31MP0003045_fibrosis1.82400758
32MP0001986_abnormal_taste_sensitivity1.74048716
33MP0003787_abnormal_imprinting1.73143824
34MP0005360_urolithiasis1.71295033
35MP0002168_other_aberrant_phenotype1.70567996
36MP0008875_abnormal_xenobiotic_pharmacok1.69367435
37MP0005646_abnormal_pituitary_gland1.66158637
38MP0003195_calcinosis1.65357983
39MP0001501_abnormal_sleep_pattern1.63231443
40MP0001764_abnormal_homeostasis1.61275268
41MP0006036_abnormal_mitochondrial_physio1.61066500
42MP0000383_abnormal_hair_follicle1.61044036
43MP0005253_abnormal_eye_physiology1.59688057
44MP0010386_abnormal_urinary_bladder1.59117454
45MP0002272_abnormal_nervous_system1.55529379
46MP0004859_abnormal_synaptic_plasticity1.54336829
47MP0005671_abnormal_response_to1.53676634
48MP0000751_myopathy1.52209931
49MP0000343_altered_response_to1.50665453
50MP0006276_abnormal_autonomic_nervous1.46221683
51MP0000427_abnormal_hair_cycle1.42397885
52MP0000467_abnormal_esophagus_morphology1.41525747
53MP0003879_abnormal_hair_cell1.39851538
54MP0000631_abnormal_neuroendocrine_gland1.38777723
55MP0004885_abnormal_endolymph1.37290600
56MP0002909_abnormal_adrenal_gland1.33137207
57MP0000762_abnormal_tongue_morphology1.32999977
58MP0004381_abnormal_hair_follicle1.25034074
59MP0003693_abnormal_embryo_hatching1.24449977
60MP0005084_abnormal_gallbladder_morpholo1.24428912
61MP0005332_abnormal_amino_acid1.23218013
62MP0006035_abnormal_mitochondrial_morpho1.21862495
63MP0001963_abnormal_hearing_physiology1.21041758
64MP0001485_abnormal_pinna_reflex1.21029613
65MP0001486_abnormal_startle_reflex1.19472128
66MP0005085_abnormal_gallbladder_physiolo1.18692793
67MP0003880_abnormal_central_pattern1.18409973
68MP0003941_abnormal_skin_development1.18046218
69MP0006292_abnormal_olfactory_placode1.17780192
70MP0002734_abnormal_mechanical_nocicepti1.17107024
71MP0003718_maternal_effect1.16988616
72MP0010678_abnormal_skin_adnexa1.15566316
73MP0009764_decreased_sensitivity_to1.15369279
74MP0005171_absent_coat_pigmentation1.13337338
75MP0009046_muscle_twitch1.11898762
76MP0009745_abnormal_behavioral_response1.10981159
77MP0008775_abnormal_heart_ventricle1.10030454
78MP0005174_abnormal_tail_pigmentation1.09682201
79MP0004742_abnormal_vestibular_system1.09155724
80MP0003938_abnormal_ear_development1.07663060
81MP0000026_abnormal_inner_ear1.07404816
82MP0002638_abnormal_pupillary_reflex1.07285400
83MP0002138_abnormal_hepatobiliary_system1.05981678
84MP0001984_abnormal_olfaction1.04395453
85MP0001440_abnormal_grooming_behavior1.04322641
86MP0003137_abnormal_impulse_conducting1.04197716
87MP0002693_abnormal_pancreas_physiology1.03293708
88MP0002095_abnormal_skin_pigmentation1.02551056
89MP0001919_abnormal_reproductive_system1.01966642
90MP0005410_abnormal_fertilization1.01248250
91MP0002572_abnormal_emotion/affect_behav1.01233690
92MP0003635_abnormal_synaptic_transmissio0.99757802
93MP0005636_abnormal_mineral_homeostasis0.99359133
94MP0002736_abnormal_nociception_after0.96153181
95MP0003122_maternal_imprinting0.95473495
96MP0004133_heterotaxia0.94005688
97MP0002063_abnormal_learning/memory/cond0.93375486
98MP0001188_hyperpigmentation0.92279750
99MP0002928_abnormal_bile_duct0.92240116
100MP0001756_abnormal_urination0.91600630
101MP0005423_abnormal_somatic_nervous0.91478136
102MP0000681_abnormal_thyroid_gland0.91311343
103MP0005220_abnormal_exocrine_pancreas0.91178963
104MP0001873_stomach_inflammation0.90295580
105MP0000230_abnormal_systemic_arterial0.88661669
106MP0001664_abnormal_digestion0.88646181
107MP0000538_abnormal_urinary_bladder0.88489844
108MP0008058_abnormal_DNA_repair0.88122952
109MP0002733_abnormal_thermal_nociception0.87967339
110MP0003283_abnormal_digestive_organ0.87130475
111MP0004142_abnormal_muscle_tone0.86817607
112MP0004270_analgesia0.86799453
113MP0005386_behavior/neurological_phenoty0.86611588
114MP0004924_abnormal_behavior0.86611588
115MP0001905_abnormal_dopamine_level0.83313089
116MP0005379_endocrine/exocrine_gland_phen0.83278918
117MP0005389_reproductive_system_phenotype0.82320716
118MP0001270_distended_abdomen0.82265187
119MP0002064_seizures0.81702819
120MP0002177_abnormal_outer_ear0.80908295
121MP0002139_abnormal_hepatobiliary_system0.80678347
122MP0003121_genomic_imprinting0.78722259
123MP0002067_abnormal_sensory_capabilities0.78462528
124MP0005075_abnormal_melanosome_morpholog0.77890225
125MP0009384_cardiac_valve_regurgitation0.77361396
126MP0002098_abnormal_vibrissa_morphology0.76528415
127MP0003690_abnormal_glial_cell0.76092115
128MP0000013_abnormal_adipose_tissue0.73200247
129MP0004215_abnormal_myocardial_fiber0.72894669
130MP0001970_abnormal_pain_threshold0.71637991
131MP0002060_abnormal_skin_morphology0.71038471
132MP0005623_abnormal_meninges_morphology0.69949898
133MP0003786_premature_aging0.69739939
134MP0005387_immune_system_phenotype0.69248883
135MP0001790_abnormal_immune_system0.69248883
136MP0008789_abnormal_olfactory_epithelium0.68996621
137MP0000778_abnormal_nervous_system0.68766891
138MP0000647_abnormal_sebaceous_gland0.68189324
139MP0010771_integument_phenotype0.67429436
140MP0002090_abnormal_vision0.67186682
141MP0004043_abnormal_pH_regulation0.67144949
142MP0003633_abnormal_nervous_system0.66879044
143MP0006072_abnormal_retinal_apoptosis0.64716335
144MP0005248_abnormal_Harderian_gland0.64005861
145MP0002557_abnormal_social/conspecific_i0.60942497
146MP0002796_impaired_skin_barrier0.57267724
147MP0002876_abnormal_thyroid_physiology0.57098516
148MP0001502_abnormal_circadian_rhythm0.56581265
149MP0002184_abnormal_innervation0.55622468
150MP0008874_decreased_physiological_sensi0.55274023
151MP0005365_abnormal_bile_salt0.54586581
152MP0000462_abnormal_digestive_system0.53832261
153MP0005395_other_phenotype0.52482156
154MP0010030_abnormal_orbit_morphology0.51760902
155MP0000470_abnormal_stomach_morphology0.50819933
156MP0002932_abnormal_joint_morphology0.49943178
157MP0000569_abnormal_digit_pigmentation0.48844573
158MP0001853_heart_inflammation0.48531984
159MP0001835_abnormal_antigen_presentation0.48387142
160MP0005167_abnormal_blood-brain_barrier0.48021033
161MP0000490_abnormal_crypts_of0.47393230

Predicted human phenotypes

RankGene SetZ-score
1Tetany (HP:0001281)5.65923238
2Panhypogammaglobulinemia (HP:0003139)5.22630221
3Spastic paraparesis (HP:0002313)4.92584981
4Congenital malformation of the right heart (HP:0011723)4.83533441
5Double outlet right ventricle (HP:0001719)4.83533441
6Unilateral renal agenesis (HP:0000122)4.81946596
7Distal lower limb amyotrophy (HP:0008944)4.55128545
8Distal lower limb muscle weakness (HP:0009053)4.47792852
9Abnormal delayed hypersensitivity skin test (HP:0002963)4.43613850
10Upper limb muscle weakness (HP:0003484)3.74746747
11Chronic mucocutaneous candidiasis (HP:0002728)3.72952472
12Recurrent cutaneous fungal infections (HP:0011370)3.72952472
13Elfin facies (HP:0004428)3.69038872
14Lower limb amyotrophy (HP:0007210)3.62615106
15Abnormality of the aortic arch (HP:0012303)3.55828497
16Partial duplication of thumb phalanx (HP:0009944)3.53947841
17Pancreatic cysts (HP:0001737)3.53416931
18Nonprogressive disorder (HP:0003680)3.38866776
19Hyperthyroidism (HP:0000836)3.34935800
20Hepatic necrosis (HP:0002605)3.33569012
21Overriding aorta (HP:0002623)3.29647031
22Paraparesis (HP:0002385)3.27118450
23Attenuation of retinal blood vessels (HP:0007843)3.25891782
24Mitochondrial inheritance (HP:0001427)3.23773506
25Renal cortical cysts (HP:0000803)3.23267715
26Amblyopia (HP:0000646)3.21186134
27Pancreatic fibrosis (HP:0100732)3.20187754
28Abnormality of the renal cortex (HP:0011035)3.19770743
29Increased CSF lactate (HP:0002490)3.17632413
30Hepatocellular necrosis (HP:0001404)3.13598768
31Partial duplication of the phalanx of hand (HP:0009999)3.09699205
32Aplasia/Hypoplasia of the fovea (HP:0008060)3.09166686
33Hypoplasia of the fovea (HP:0007750)3.09166686
34Acute necrotizing encephalopathy (HP:0006965)3.06969263
35Hypoproteinemia (HP:0003075)3.06373854
36Abnormality of the parathyroid morphology (HP:0011766)3.06205040
37Thyroiditis (HP:0100646)3.02813157
38Type II lissencephaly (HP:0007260)3.02730594
39Exotropia (HP:0000577)3.01136543
40Hypoparathyroidism (HP:0000829)2.97804899
41Agammaglobulinemia (HP:0004432)2.95953573
42Abnormal drinking behavior (HP:0030082)2.95265344
43Polydipsia (HP:0001959)2.95265344
44Colitis (HP:0002583)2.95114461
45Abnormality of T cell physiology (HP:0011840)2.95027227
46Type I transferrin isoform profile (HP:0003642)2.88710846
47Obstructive lung disease (HP:0006536)2.85911688
48Chronic obstructive pulmonary disease (HP:0006510)2.85911688
49Progressive macrocephaly (HP:0004481)2.83728995
50Abnormality of B cell number (HP:0010975)2.80951810
51Generalized aminoaciduria (HP:0002909)2.79106785
52Conical tooth (HP:0000698)2.77656059
53Recurrent fungal infections (HP:0002841)2.76397214
54Abnormal mitochondria in muscle tissue (HP:0008316)2.75491287
55B lymphocytopenia (HP:0010976)2.74681451
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.70090393
57Abnormal protein N-linked glycosylation (HP:0012347)2.70090393
58Abnormal protein glycosylation (HP:0012346)2.70090393
59Abnormal glycosylation (HP:0012345)2.70090393
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.66082708
61Abnormality of alanine metabolism (HP:0010916)2.66082708
62Hyperalaninemia (HP:0003348)2.66082708
63Acute encephalopathy (HP:0006846)2.65050590
64Abnormal sex determination (HP:0012244)2.64625360
65Sex reversal (HP:0012245)2.64625360
66Progressive inability to walk (HP:0002505)2.63225363
67Tubular atrophy (HP:0000092)2.62430581
68True hermaphroditism (HP:0010459)2.61148807
69Neonatal respiratory distress (HP:0002643)2.60837557
70Abnormality of dental color (HP:0011073)2.58742686
71Cerebellar dysplasia (HP:0007033)2.54731804
72Recurrent viral infections (HP:0004429)2.53676662
73Viral hepatitis (HP:0006562)2.52181101
74Hypoplastic left heart (HP:0004383)2.51765005
75Esotropia (HP:0000565)2.50023663
76Medial flaring of the eyebrow (HP:0010747)2.48588913
77Severe combined immunodeficiency (HP:0004430)2.48545728
78Onycholysis (HP:0001806)2.45100149
79Abnormal rod and cone electroretinograms (HP:0008323)2.44436793
80Aplasia cutis congenita (HP:0001057)2.44286121
81Febrile seizures (HP:0002373)2.43391311
82Exercise-induced myalgia (HP:0003738)2.43136903
83Decreased central vision (HP:0007663)2.43021906
84Abnormality of the diencephalon (HP:0010662)2.42672662
85Blue irides (HP:0000635)2.42436825
86Abolished electroretinogram (ERG) (HP:0000550)2.40803793
87Gaze-evoked nystagmus (HP:0000640)2.40488324
88Broad metatarsal (HP:0001783)2.38248446
89Nephronophthisis (HP:0000090)2.35494107
90Lipid accumulation in hepatocytes (HP:0006561)2.35380861
91Molar tooth sign on MRI (HP:0002419)2.34863232
92Abnormality of midbrain morphology (HP:0002418)2.34863232
93Renal dysplasia (HP:0000110)2.34862533
94Seborrheic dermatitis (HP:0001051)2.33319557
95Increased hepatocellular lipid droplets (HP:0006565)2.32271300
96Delusions (HP:0000746)2.31189917
97Overfolded helix (HP:0000396)2.29836521
98Abnormal biliary tract physiology (HP:0012439)2.29831298
99Bile duct proliferation (HP:0001408)2.29831298
100Cholelithiasis (HP:0001081)2.29157885
101Patellar dislocation (HP:0002999)2.25416288
102Renovascular hypertension (HP:0100817)2.24705252
103Polyuria (HP:0000103)2.23968884
104Hyperventilation (HP:0002883)2.23872500
105Hypertensive crisis (HP:0100735)2.22980200
106Inability to walk (HP:0002540)2.22726056
107Severe muscular hypotonia (HP:0006829)2.22423676
108IgG deficiency (HP:0004315)2.22048975
109Myokymia (HP:0002411)2.21136357
110Abnormality of the renal medulla (HP:0100957)2.19453579
111Decreased electroretinogram (ERG) amplitude (HP:0000654)2.18651740
112Hypoalbuminemia (HP:0003073)2.17825891
113Abnormal albumin level (HP:0012116)2.17825891
114Aplasia involving bones of the extremities (HP:0009825)2.17230204
115Aplasia involving bones of the upper limbs (HP:0009823)2.17230204
116Aplasia of the phalanges of the hand (HP:0009802)2.17230204
117Pachygyria (HP:0001302)2.14572381
118Hemiparesis (HP:0001269)2.12755018
119Lissencephaly (HP:0001339)2.12693482
120Flat cornea (HP:0007720)2.12553583
121Periauricular skin pits (HP:0100277)2.11071472
122Preauricular pit (HP:0004467)2.11071472
123Protruding tongue (HP:0010808)2.09461515
124Macrocytic anemia (HP:0001972)2.09236398
125Delayed CNS myelination (HP:0002188)2.07561125
126Abnormal gallbladder morphology (HP:0012437)2.07408360
127Abnormally folded helix (HP:0008544)2.07240166
128Abnormality of the heme biosynthetic pathway (HP:0010472)2.05984414
129Renal Fanconi syndrome (HP:0001994)2.04740515
130Inflammation of the large intestine (HP:0002037)2.03472148
131CNS demyelination (HP:0007305)2.02551910
132Short 5th finger (HP:0009237)2.02429641
133Hypoplasia of the thymus (HP:0000778)2.01068244
134Tongue fasciculations (HP:0001308)2.00962060
135Abnormality of the fovea (HP:0000493)2.00622270
136Aplasia/Hypoplasia of the macula (HP:0008059)1.99131240
137Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.98871074
138Rib fusion (HP:0000902)1.97211982
139Acne (HP:0001061)1.97074560
140Brushfield spots (HP:0001088)1.96711099
141Pendular nystagmus (HP:0012043)1.96605019
142Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.96591863
143Acanthocytosis (HP:0001927)1.96573139
144Short middle phalanx of the 5th finger (HP:0004220)1.95401685
145Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93964357
146Reduced antithrombin III activity (HP:0001976)1.93560007
147Abnormality of urine glucose concentration (HP:0011016)1.93226408
148Glycosuria (HP:0003076)1.93226408
149Lactic acidosis (HP:0003128)1.92811061
150Respiratory failure (HP:0002878)1.91492542
151Cerebral edema (HP:0002181)1.90279849
152Petechiae (HP:0000967)1.90201322
153Insomnia (HP:0100785)1.90010412
154Pelvic girdle muscle weakness (HP:0003749)1.90004669
155Increased serum lactate (HP:0002151)1.89913415
156Hyperacusis (HP:0010780)1.89366893
157Gait imbalance (HP:0002141)1.87462784
158Increased corneal curvature (HP:0100692)1.86986673
159Keratoconus (HP:0000563)1.86986673
160Shoulder girdle muscle weakness (HP:0003547)1.86846059
161Optic disc pallor (HP:0000543)1.85562629
162Severe visual impairment (HP:0001141)1.84910287
163Abnormality of proline metabolism (HP:0010907)1.84268383
164Hydroxyprolinuria (HP:0003080)1.84268383
165Hypoplasia of the pons (HP:0012110)1.84080477
166Congenital primary aphakia (HP:0007707)1.83011010
167Hypoplastic heart (HP:0001961)1.81528074
168Abnormality of macular pigmentation (HP:0008002)1.81262939
169Transposition of the great arteries (HP:0001669)1.81134264
170Abnormal connection of the cardiac segments (HP:0011545)1.81134264
171Abnormal ventriculo-arterial connection (HP:0011563)1.81134264
172Popliteal pterygium (HP:0009756)1.79064961
173Recurrent skin infections (HP:0001581)1.78940579
174Methylmalonic acidemia (HP:0002912)1.78166105
175Congenital stationary night blindness (HP:0007642)1.77314249
176Sensory axonal neuropathy (HP:0003390)1.76631573
177Truncus arteriosus (HP:0001660)1.75319811
178Abnormal urine output (HP:0012590)1.75280325
179Retinal dysplasia (HP:0007973)1.75118222
180Renal duplication (HP:0000075)1.75054117
181Abnormality of small intestinal villus morphology (HP:0011472)1.74928408
182Villous atrophy (HP:0011473)1.74928408
183Abnormality of the phalanges of the 5th finger (HP:0004213)1.74722388
184Methylmalonic aciduria (HP:0012120)1.73938871
185Gastrointestinal inflammation (HP:0004386)1.73457837
186Abnormality of the hip-girdle musculature (HP:0001445)1.73379670
187Abnormality of the musculature of the pelvis (HP:0001469)1.73379670
188Broad-based gait (HP:0002136)1.73328430
189Abnormality of the tricuspid valve (HP:0001702)1.71943916
190Corneal erosion (HP:0200020)1.71881717
191Bifid uvula (HP:0000193)1.70086379
192Centrally nucleated skeletal muscle fibers (HP:0003687)1.68389169
193Confusion (HP:0001289)1.67398546
194Pallor (HP:0000980)1.66776462
195Abnormality of T cells (HP:0002843)1.66160054

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B5.55919160
2FRK4.99275892
3OBSCN4.27270723
4NTRK13.95976226
5MST43.79709303
6IRAK33.66138992
7STK393.57645935
8MAP3K93.25622568
9MAP4K23.18136746
10NTRK22.99590294
11TAOK22.91172316
12PDK22.59278395
13FGFR22.58362822
14EPHA42.50867199
15EPHA32.44608090
16PINK12.28718356
17MARK12.21476531
18WNK31.99890382
19STK241.98928494
20TAOK31.92229000
21NTRK31.91897042
22CCNB11.91593619
23PAK31.91202768
24CASK1.89883823
25ADRBK21.85592110
26IKBKE1.84906845
27CAMK1D1.59191092
28IRAK41.58869377
29TRIM281.58218777
30BMPR1B1.48946068
31BCKDK1.44998480
32DAPK21.44259458
33EIF2AK21.43202875
34TBK11.39368387
35PIM21.39308712
36TNK21.31698755
37TLK11.29880589
38CSNK1G31.29637602
39TNIK1.26969511
40CAMK1G1.22908809
41UHMK11.22824463
42WNK41.22188702
43NUAK11.17788835
44MAPK131.17205854
45BCR1.16695407
46MST1R1.15189449
47CSNK1G21.10947041
48KDR1.10841570
49CAMKK21.09660738
50PRKCQ1.07616572
51CSNK1G11.07199570
52MAPKAPK31.06412102
53PAK61.05121576
54PRKCG1.00897891
55TESK20.99845698
56CSNK1A1L0.99406651
57ERBB30.99282917
58CDK80.93367633
59BMPR20.87851631
60CAMK40.87806292
61PIM10.87444842
62INSRR0.85873416
63PRKCE0.85570737
64RPS6KA40.84962815
65MUSK0.83417690
66DYRK20.83099842
67MAP3K140.83077350
68MAP3K130.82984038
69TEC0.80987534
70SGK10.80558989
71IKBKB0.80256309
72MAP2K60.79095008
73TRPM70.75449580
74RPS6KA50.74626711
75STK110.72784572
76TIE10.71590890
77GRK10.70696624
78MAPKAPK50.69330455
79FGFR40.68318913
80ADRBK10.67812968
81ITK0.67292526
82LIMK10.67222794
83CAMK2B0.67170353
84MKNK20.66172094
85OXSR10.65107040
86ACVR1B0.64871952
87PLK20.64520973
88CSNK1E0.63532651
89MAPK120.62872404
90LATS10.62779140
91CAMK2A0.62420711
92IRAK10.62322926
93EPHB10.61488341
94DAPK30.61485428
95FER0.58049441
96PDPK10.54068831
97RIPK40.53553447
98TXK0.51128110
99SYK0.48878815
100KIT0.48785982
101MAP3K40.48730561
102ERBB40.48724478
103PRKCA0.48190820
104PDK10.47702624
105RPS6KA20.47505288
106WNK10.47372286
107PTK2B0.47171500
108GRK70.46574031
109CAMKK10.45118483
110CDK50.44699008
111PRKCH0.44400562
112MAP3K120.43845900
113ROCK20.43566615
114ALK0.43420223
115MAP2K70.41687814
116PRKCI0.41455833
117JAK10.40706769
118BTK0.40639075
119ABL10.40348204
120ARAF0.40202331
121STK38L0.39853143
122CSNK1A10.39506454
123PRKACA0.39070554
124CAMK10.38703492
125PKN10.37912693
126AKT10.37492631
127IRAK20.37186297
128NME10.37059578
129CDK190.36751207
130FES0.36626431
131PRKACB0.35868851
132MAP3K70.35573138
133STK40.34212408
134PRKAA10.34199153
135DYRK1B0.33127220
136RPS6KB10.33080297
137EGFR0.32575250
138LATS20.32129593
139RPS6KA60.32056026
140VRK10.32004127
141ZAK0.31942707
142PRKACG0.31758536
143MAPK40.31710125
144PRKD10.31311395
145YES10.29179944
146MKNK10.29020284
147CAMK2D0.28517656
148PHKG10.28500925
149PHKG20.28500925
150ROCK10.28426821
151STK30.28414744
152MINK10.27533168
153PTK60.27331259
154MAP3K20.27201336
155FYN0.26257831
156CAMK2G0.26066640
157LYN0.25666791
158PRKG10.25120914
159SIK20.24808359
160HIPK20.24457029

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.11463014
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.79061126
3Phototransduction_Homo sapiens_hsa047442.72088960
4PPAR signaling pathway_Homo sapiens_hsa033202.54876425
5Oxidative phosphorylation_Homo sapiens_hsa001902.53670323
6Fatty acid biosynthesis_Homo sapiens_hsa000612.21256178
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.11902408
8SNARE interactions in vesicular transport_Homo sapiens_hsa041302.03049365
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.01562439
10Regulation of autophagy_Homo sapiens_hsa041401.96852933
11Parkinsons disease_Homo sapiens_hsa050121.86949617
12Non-homologous end-joining_Homo sapiens_hsa034501.85602125
13Tryptophan metabolism_Homo sapiens_hsa003801.83891489
14Butanoate metabolism_Homo sapiens_hsa006501.79995863
15Vitamin digestion and absorption_Homo sapiens_hsa049771.74043651
16RNA polymerase_Homo sapiens_hsa030201.72517510
17Axon guidance_Homo sapiens_hsa043601.69304782
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.65359308
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.64600168
20ABC transporters_Homo sapiens_hsa020101.60101634
21Renin secretion_Homo sapiens_hsa049241.56768172
22Glutamatergic synapse_Homo sapiens_hsa047241.56196599
23Nitrogen metabolism_Homo sapiens_hsa009101.53296984
24Protein export_Homo sapiens_hsa030601.50502336
25Peroxisome_Homo sapiens_hsa041461.47104859
26Tyrosine metabolism_Homo sapiens_hsa003501.46937320
27Homologous recombination_Homo sapiens_hsa034401.46439097
28Primary immunodeficiency_Homo sapiens_hsa053401.44995097
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.44749541
30Phagosome_Homo sapiens_hsa041451.43449924
31Fatty acid metabolism_Homo sapiens_hsa012121.40554361
32Nicotine addiction_Homo sapiens_hsa050331.40096311
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.36297377
34Insulin secretion_Homo sapiens_hsa049111.35988834
35Cocaine addiction_Homo sapiens_hsa050301.35857107
36Morphine addiction_Homo sapiens_hsa050321.33729942
37Type I diabetes mellitus_Homo sapiens_hsa049401.33212084
38Fanconi anemia pathway_Homo sapiens_hsa034601.33149895
39Basal transcription factors_Homo sapiens_hsa030221.32317862
40Proteasome_Homo sapiens_hsa030501.31612107
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.31104715
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.29601172
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25208294
44Sphingolipid metabolism_Homo sapiens_hsa006001.24611706
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.23746454
46Amphetamine addiction_Homo sapiens_hsa050311.20939513
47One carbon pool by folate_Homo sapiens_hsa006701.18333761
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15134140
49Cholinergic synapse_Homo sapiens_hsa047251.14647637
50Fatty acid degradation_Homo sapiens_hsa000711.14293572
51Propanoate metabolism_Homo sapiens_hsa006401.13695302
52Leishmaniasis_Homo sapiens_hsa051401.12787848
53Ribosome_Homo sapiens_hsa030101.08588627
54GABAergic synapse_Homo sapiens_hsa047271.08137171
55Asthma_Homo sapiens_hsa053101.07228447
56Prion diseases_Homo sapiens_hsa050201.06436835
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05701664
58RNA degradation_Homo sapiens_hsa030181.03723031
59Huntingtons disease_Homo sapiens_hsa050161.03269593
60Dopaminergic synapse_Homo sapiens_hsa047281.01958479
61Rheumatoid arthritis_Homo sapiens_hsa053231.01858448
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00333719
63Steroid biosynthesis_Homo sapiens_hsa001001.00023392
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.99668202
65Selenocompound metabolism_Homo sapiens_hsa004500.99539815
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.98655192
67Circadian entrainment_Homo sapiens_hsa047130.95541844
68Olfactory transduction_Homo sapiens_hsa047400.95397216
69Staphylococcus aureus infection_Homo sapiens_hsa051500.95025811
70Tuberculosis_Homo sapiens_hsa051520.95018164
71Oxytocin signaling pathway_Homo sapiens_hsa049210.94537887
72Salivary secretion_Homo sapiens_hsa049700.94499306
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93151079
74African trypanosomiasis_Homo sapiens_hsa051430.89508025
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89027850
76Serotonergic synapse_Homo sapiens_hsa047260.88558775
77Phenylalanine metabolism_Homo sapiens_hsa003600.88498809
78Graft-versus-host disease_Homo sapiens_hsa053320.86766262
79Retinol metabolism_Homo sapiens_hsa008300.86156816
80cAMP signaling pathway_Homo sapiens_hsa040240.84520038
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.84290345
82Allograft rejection_Homo sapiens_hsa053300.83908129
83Caffeine metabolism_Homo sapiens_hsa002320.83809694
84beta-Alanine metabolism_Homo sapiens_hsa004100.83639349
85N-Glycan biosynthesis_Homo sapiens_hsa005100.83482839
86Estrogen signaling pathway_Homo sapiens_hsa049150.82934902
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79665400
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79453344
89Pyrimidine metabolism_Homo sapiens_hsa002400.79061648
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78692454
91* Taste transduction_Homo sapiens_hsa047420.78495668
92Arachidonic acid metabolism_Homo sapiens_hsa005900.78054687
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76873549
94Small cell lung cancer_Homo sapiens_hsa052220.76270789
95Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75846989
96Amoebiasis_Homo sapiens_hsa051460.74693374
97Synaptic vesicle cycle_Homo sapiens_hsa047210.74023479
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73973045
99ErbB signaling pathway_Homo sapiens_hsa040120.73673934
100Purine metabolism_Homo sapiens_hsa002300.72895127
101Autoimmune thyroid disease_Homo sapiens_hsa053200.71317315
102Ether lipid metabolism_Homo sapiens_hsa005650.71220678
103Linoleic acid metabolism_Homo sapiens_hsa005910.70913314
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70393139
105Histidine metabolism_Homo sapiens_hsa003400.69452346
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69142473
107Hematopoietic cell lineage_Homo sapiens_hsa046400.69105097
108Long-term potentiation_Homo sapiens_hsa047200.69057021
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68612821
110Metabolic pathways_Homo sapiens_hsa011000.67855025
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67776242
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67732530
113Chemical carcinogenesis_Homo sapiens_hsa052040.67325404
114Melanogenesis_Homo sapiens_hsa049160.66422493
115Chemokine signaling pathway_Homo sapiens_hsa040620.66359016
116Ras signaling pathway_Homo sapiens_hsa040140.66239200
117Fatty acid elongation_Homo sapiens_hsa000620.65942396
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65660757
119Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65508628
120B cell receptor signaling pathway_Homo sapiens_hsa046620.64504428
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63708076
122Malaria_Homo sapiens_hsa051440.63547523
123Mineral absorption_Homo sapiens_hsa049780.63219305
124Cardiac muscle contraction_Homo sapiens_hsa042600.63016814
125Calcium signaling pathway_Homo sapiens_hsa040200.62826476
126Complement and coagulation cascades_Homo sapiens_hsa046100.62214294
127Long-term depression_Homo sapiens_hsa047300.61948454
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61450025
129Ovarian steroidogenesis_Homo sapiens_hsa049130.61199395
130GnRH signaling pathway_Homo sapiens_hsa049120.60417112
131Toxoplasmosis_Homo sapiens_hsa051450.57510656
132VEGF signaling pathway_Homo sapiens_hsa043700.57107384
133Fat digestion and absorption_Homo sapiens_hsa049750.56179635
134Alzheimers disease_Homo sapiens_hsa050100.54554922
135Bile secretion_Homo sapiens_hsa049760.54201980
136Arginine biosynthesis_Homo sapiens_hsa002200.53509837
137ECM-receptor interaction_Homo sapiens_hsa045120.51915353
138Focal adhesion_Homo sapiens_hsa045100.50294812
139Platelet activation_Homo sapiens_hsa046110.50106509
140Collecting duct acid secretion_Homo sapiens_hsa049660.49781151
141Pancreatic secretion_Homo sapiens_hsa049720.49775743
142T cell receptor signaling pathway_Homo sapiens_hsa046600.49164927
143Maturity onset diabetes of the young_Homo sapiens_hsa049500.47178998
144Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47017775
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46988011
146Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45837256
147Glycerophospholipid metabolism_Homo sapiens_hsa005640.44186731
148Nucleotide excision repair_Homo sapiens_hsa034200.41892607
149Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40135357
150Folate biosynthesis_Homo sapiens_hsa007900.38171181
151Drug metabolism - other enzymes_Homo sapiens_hsa009830.35344374
152Antigen processing and presentation_Homo sapiens_hsa046120.35340256
153Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33728900
154Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32632395

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