CALM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.52729516
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.51400332
3vocalization behavior (GO:0071625)5.45643879
4sodium ion export (GO:0071436)5.42036134
5neuron cell-cell adhesion (GO:0007158)5.20221160
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.18608368
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.09088631
8protein localization to synapse (GO:0035418)5.04846470
9glutamate secretion (GO:0014047)5.04807667
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.98847980
11regulation of synaptic vesicle exocytosis (GO:2000300)4.83548334
12synaptic vesicle maturation (GO:0016188)4.79099129
13regulation of glutamate receptor signaling pathway (GO:1900449)4.71120210
14locomotory exploration behavior (GO:0035641)4.69837867
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.48310238
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.40977186
17cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.39491656
18neuronal action potential propagation (GO:0019227)4.38720394
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.37786185
20glutamate receptor signaling pathway (GO:0007215)4.35306688
21L-amino acid import (GO:0043092)4.33163829
22exploration behavior (GO:0035640)4.28627079
23regulation of synaptic vesicle transport (GO:1902803)4.27420693
24regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.26211475
25regulation of long-term neuronal synaptic plasticity (GO:0048169)4.21069134
26potassium ion homeostasis (GO:0055075)4.16049861
27neuron-neuron synaptic transmission (GO:0007270)4.07476383
28neurotransmitter secretion (GO:0007269)4.05016364
29gamma-aminobutyric acid signaling pathway (GO:0007214)4.04216373
30neuron recognition (GO:0008038)4.00533685
31synaptic transmission, glutamatergic (GO:0035249)4.00179199
32regulation of neuronal synaptic plasticity (GO:0048168)3.98737088
33presynaptic membrane assembly (GO:0097105)3.93409355
34potassium ion import (GO:0010107)3.89853443
35regulation of excitatory postsynaptic membrane potential (GO:0060079)3.86482330
36layer formation in cerebral cortex (GO:0021819)3.79877327
37amino acid import (GO:0043090)3.78588009
38cell communication by electrical coupling (GO:0010644)3.73340507
39postsynaptic membrane organization (GO:0001941)3.72703796
40cellular sodium ion homeostasis (GO:0006883)3.72028436
41regulation of synapse structural plasticity (GO:0051823)3.71275441
42neurotransmitter-gated ion channel clustering (GO:0072578)3.70339060
43regulation of postsynaptic membrane potential (GO:0060078)3.70333568
44dendritic spine morphogenesis (GO:0060997)3.68278370
45negative regulation of synaptic transmission, GABAergic (GO:0032229)3.66200419
46long-term synaptic potentiation (GO:0060291)3.64362040
47presynaptic membrane organization (GO:0097090)3.62472725
48synaptic vesicle endocytosis (GO:0048488)3.60495625
49response to histamine (GO:0034776)3.59629795
50positive regulation of membrane potential (GO:0045838)3.57175984
51neuronal ion channel clustering (GO:0045161)3.56742109
52long-term memory (GO:0007616)3.56258126
53proline transport (GO:0015824)3.56115651
54axonal fasciculation (GO:0007413)3.55729395
55regulation of synaptic plasticity (GO:0048167)3.54145469
56positive regulation of neurotransmitter secretion (GO:0001956)3.53267978
57G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.49749275
58positive regulation of synapse maturation (GO:0090129)3.48899243
59membrane depolarization during action potential (GO:0086010)3.46058068
60regulation of neurotransmitter secretion (GO:0046928)3.45627658
61regulation of vesicle fusion (GO:0031338)3.44470920
62transmission of nerve impulse (GO:0019226)3.42956842
63neurotransmitter uptake (GO:0001504)3.42899508
64regulation of dendritic spine morphogenesis (GO:0061001)3.42725352
65neurotransmitter transport (GO:0006836)3.41692782
66regulation of glutamate secretion (GO:0014048)3.38019751
67regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.36647421
68central nervous system myelination (GO:0022010)3.36034004
69axon ensheathment in central nervous system (GO:0032291)3.36034004
70regulation of synapse maturation (GO:0090128)3.36016262
71regulation of synaptic transmission, glutamatergic (GO:0051966)3.33196907
72behavioral response to cocaine (GO:0048148)3.31916671
73positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.31907189
74membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.31891538
75neuromuscular process controlling balance (GO:0050885)3.30661856
76activation of protein kinase A activity (GO:0034199)3.28417328
77positive regulation of neurotransmitter transport (GO:0051590)3.28097288
78gamma-aminobutyric acid transport (GO:0015812)3.27841904
79G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.26158560
80behavioral defense response (GO:0002209)3.24463667
81behavioral fear response (GO:0001662)3.24463667
82positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.24254296
83regulation of ARF protein signal transduction (GO:0032012)3.23583887
84cellular potassium ion homeostasis (GO:0030007)3.20988454
85fear response (GO:0042596)3.19752596
86* regulation of voltage-gated calcium channel activity (GO:1901385)3.16313796
87synapse assembly (GO:0007416)3.13832410
88response to auditory stimulus (GO:0010996)3.13308533
89regulation of neurotransmitter transport (GO:0051588)3.12424794
90membrane depolarization (GO:0051899)3.11503067
91innervation (GO:0060384)3.11363057
92cell communication involved in cardiac conduction (GO:0086065)3.11139863
93acidic amino acid transport (GO:0015800)3.10206755
94regulation of neurotransmitter levels (GO:0001505)3.09892314
95regulation of dendritic spine development (GO:0060998)3.09706175
96vesicle transport along microtubule (GO:0047496)3.09068109
97learning (GO:0007612)3.07305902
98cerebellar granule cell differentiation (GO:0021707)3.02709338
99neuromuscular synaptic transmission (GO:0007274)3.02624305
100neuromuscular process controlling posture (GO:0050884)3.02144927
101negative regulation of dendrite morphogenesis (GO:0050774)3.00533685
102positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.00044669
103regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.98373686
104negative regulation of microtubule polymerization (GO:0031115)2.97977262
105* synaptic transmission (GO:0007268)2.97118698
106serotonin metabolic process (GO:0042428)2.96219733
107ATP hydrolysis coupled proton transport (GO:0015991)2.95480727
108energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.95480727
109regulation of synaptic transmission (GO:0050804)2.94915205
110mating behavior (GO:0007617)2.94704965
111positive regulation of synaptic transmission, GABAergic (GO:0032230)2.91723835
112positive regulation of dendritic spine morphogenesis (GO:0061003)2.91141333
113organelle transport along microtubule (GO:0072384)2.90803782
114synaptic vesicle transport (GO:0048489)2.90511244
115establishment of synaptic vesicle localization (GO:0097480)2.90511244
116regulation of protein kinase A signaling (GO:0010738)2.90316933
117long term synaptic depression (GO:0060292)2.89681275
118vesicle docking involved in exocytosis (GO:0006904)2.89370656
119signal release (GO:0023061)2.89303240
120positive regulation of synaptic transmission (GO:0050806)2.88897554
121cerebellar Purkinje cell differentiation (GO:0021702)2.87837948
122social behavior (GO:0035176)2.87521692
123intraspecies interaction between organisms (GO:0051703)2.87521692
124female mating behavior (GO:0060180)2.87420400
125membrane hyperpolarization (GO:0060081)2.86608438
126dendritic spine organization (GO:0097061)2.86092354
127positive regulation of dendritic spine development (GO:0060999)2.86079756
128auditory behavior (GO:0031223)2.86010905
129startle response (GO:0001964)2.85806791
130positive regulation of synapse assembly (GO:0051965)2.84336872

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.08719127
2GBX2_23144817_ChIP-Seq_PC3_Human4.04312385
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.21262259
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.12235108
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08112556
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.74090766
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.69980415
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64044655
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64044655
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59116487
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53321033
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50326901
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.49987399
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47017577
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.46084458
16TAF15_26573619_Chip-Seq_HEK293_Human2.40528228
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.31394592
18* RARB_27405468_Chip-Seq_BRAIN_Mouse2.30710190
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15887943
20* REST_18959480_ChIP-ChIP_MESCs_Mouse2.12780186
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.11427808
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09065308
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.08579474
24DROSHA_22980978_ChIP-Seq_HELA_Human2.08042885
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04917357
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04878710
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04034682
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96889505
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84030513
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.83263330
31* SMAD4_21799915_ChIP-Seq_A2780_Human1.83122075
32AR_21572438_ChIP-Seq_LNCaP_Human1.79088509
33P300_19829295_ChIP-Seq_ESCs_Human1.76353656
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70305832
35RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.63114512
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62160595
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60122157
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57284370
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56829262
40TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54686511
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54084668
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53996281
43VDR_22108803_ChIP-Seq_LS180_Human1.52240519
44NR3C1_23031785_ChIP-Seq_PC12_Mouse1.51523304
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50385628
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49968664
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47894644
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.47258426
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43865015
50FUS_26573619_Chip-Seq_HEK293_Human1.40650750
51ZNF274_21170338_ChIP-Seq_K562_Hela1.40521894
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40367331
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40236552
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.37792787
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.37669253
56AR_25329375_ChIP-Seq_VCAP_Human1.36092055
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.32497555
58IGF1R_20145208_ChIP-Seq_DFB_Human1.31515564
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.31286491
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28652430
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.27553975
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25684659
63* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22778919
64* RNF2_27304074_Chip-Seq_NSC_Mouse1.22775569
65* STAT3_23295773_ChIP-Seq_U87_Human1.22615073
66PRDM14_20953172_ChIP-Seq_ESCs_Human1.21669615
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21505293
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19480901
69ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18815317
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17562371
71RING1B_27294783_Chip-Seq_ESCs_Mouse1.16666634
72ER_23166858_ChIP-Seq_MCF-7_Human1.16403442
73JUN_21703547_ChIP-Seq_K562_Human1.16351906
74* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12027883
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11872267
76* TCF4_23295773_ChIP-Seq_U87_Human1.11799955
77* RUNX2_22187159_ChIP-Seq_PCA_Human1.09277589
78* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09106034
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.08960871
80* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05770153
81* AR_19668381_ChIP-Seq_PC3_Human1.05488533
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05119336
83TP53_18474530_ChIP-ChIP_U2OS_Human1.03578150
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03255472
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.02953184
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02749796
87AHR_22903824_ChIP-Seq_MCF-7_Human1.02628578
88* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00768498
89ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00694568
90BCAT_22108803_ChIP-Seq_LS180_Human1.00641397
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98524686
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98524686
93YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98370619
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96371721
95BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96297346
96TP53_16413492_ChIP-PET_HCT116_Human0.96016050
97RING1B_27294783_Chip-Seq_NPCs_Mouse0.95838063
98WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94020014
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93239134
100SMAD3_21741376_ChIP-Seq_ESCs_Human0.92970027
101CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92925071
102* TET1_21490601_ChIP-Seq_MESCs_Mouse0.91342801
103LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91331891
104KDM2B_26808549_Chip-Seq_REH_Human0.89439432
105E2F1_18555785_Chip-Seq_ESCs_Mouse0.88446051
106MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88418546
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88094374
108EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87320702
109CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84924033
110* KDM2B_26808549_Chip-Seq_K562_Human0.83115860
111SMAD4_21741376_ChIP-Seq_HESCs_Human0.82900511
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.81895823
113* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80901295
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.80539589
115OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.79433308
116* CTCF_27219007_Chip-Seq_Bcells_Human0.79015982
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78685795
118* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.77780976

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.86364868
2MP0003880_abnormal_central_pattern5.47659775
3MP0003635_abnormal_synaptic_transmissio4.08580301
4MP0004270_analgesia3.88344880
5MP0009745_abnormal_behavioral_response3.49457862
6MP0002063_abnormal_learning/memory/cond3.35588758
7MP0001968_abnormal_touch/_nociception3.31438756
8MP0002064_seizures3.15998168
9MP0009046_muscle_twitch3.03121644
10MP0002572_abnormal_emotion/affect_behav2.88979141
11MP0002734_abnormal_mechanical_nocicepti2.82913758
12MP0002736_abnormal_nociception_after2.73698124
13MP0002272_abnormal_nervous_system2.62432476
14MP0002735_abnormal_chemical_nociception2.60211638
15MP0002822_catalepsy2.55738749
16MP0001440_abnormal_grooming_behavior2.47162705
17MP0001486_abnormal_startle_reflex2.40125958
18MP0005423_abnormal_somatic_nervous2.38094913
19MP0001501_abnormal_sleep_pattern2.35316158
20MP0001984_abnormal_olfaction2.32446953
21MP0006276_abnormal_autonomic_nervous2.18270231
22MP0002733_abnormal_thermal_nociception2.16369092
23MP0001970_abnormal_pain_threshold2.12908149
24MP0002067_abnormal_sensory_capabilities2.07010635
25MP0002184_abnormal_innervation2.01585295
26MP0000778_abnormal_nervous_system2.00064699
27MP0003329_amyloid_beta_deposits1.99982108
28MP0001529_abnormal_vocalization1.87991398
29MP0005386_behavior/neurological_phenoty1.87033143
30MP0004924_abnormal_behavior1.87033143
31MP0002557_abnormal_social/conspecific_i1.75576478
32MP0003690_abnormal_glial_cell1.74109685
33MP0009780_abnormal_chondrocyte_physiolo1.68575029
34MP0001905_abnormal_dopamine_level1.65119647
35MP0004811_abnormal_neuron_physiology1.64969966
36MP0003879_abnormal_hair_cell1.58037883
37MP0008569_lethality_at_weaning1.57516857
38MP0004858_abnormal_nervous_system1.54401219
39MP0002837_dystrophic_cardiac_calcinosis1.48471788
40MP0000955_abnormal_spinal_cord1.48125880
41MP0002909_abnormal_adrenal_gland1.48004622
42MP0001188_hyperpigmentation1.47488391
43MP0002882_abnormal_neuron_morphology1.41313113
44MP0002066_abnormal_motor_capabilities/c1.40381397
45MP0010386_abnormal_urinary_bladder1.34268493
46MP0005646_abnormal_pituitary_gland1.32629072
47MP0005645_abnormal_hypothalamus_physiol1.26318484
48MP0003633_abnormal_nervous_system1.24625966
49MP0003787_abnormal_imprinting1.21788250
50MP0004142_abnormal_muscle_tone1.21583402
51MP0001502_abnormal_circadian_rhythm1.17905780
52MP0003631_nervous_system_phenotype1.08919278
53MP0003123_paternal_imprinting1.07716503
54MP0004742_abnormal_vestibular_system1.07208244
55MP0002152_abnormal_brain_morphology1.06288209
56MP0004145_abnormal_muscle_electrophysio1.00708003
57MP0003122_maternal_imprinting1.00674388
58MP0002876_abnormal_thyroid_physiology0.99701150
59MP0004885_abnormal_endolymph0.99444451
60MP0002229_neurodegeneration0.99059113
61MP0008872_abnormal_physiological_respon0.96513169
62MP0005551_abnormal_eye_electrophysiolog0.95703842
63MP0005499_abnormal_olfactory_system0.95412170
64MP0005394_taste/olfaction_phenotype0.95412170
65MP0000013_abnormal_adipose_tissue0.95249968
66MP0000604_amyloidosis0.94489594
67MP0001963_abnormal_hearing_physiology0.89817818
68MP0004147_increased_porphyrin_level0.89523803
69MP0008874_decreased_physiological_sensi0.89430032
70MP0004484_altered_response_of0.86404543
71MP0002069_abnormal_eating/drinking_beha0.86122628
72MP0005535_abnormal_body_temperature0.83651089
73MP0002752_abnormal_somatic_nervous0.83638327
74MP0005167_abnormal_blood-brain_barrier0.82782556
75MP0003634_abnormal_glial_cell0.80556560
76MP0008877_abnormal_DNA_methylation0.80248371
77MP0005409_darkened_coat_color0.77790305
78MP0000751_myopathy0.77692284
79MP0004085_abnormal_heartbeat0.76419267
80MP0001986_abnormal_taste_sensitivity0.72707484
81MP0001664_abnormal_digestion0.72136368
82MP0004510_myositis0.72110622
83MP0001485_abnormal_pinna_reflex0.71971628
84MP0003632_abnormal_nervous_system0.71521674
85MP0009379_abnormal_foot_pigmentation0.71269431
86MP0000631_abnormal_neuroendocrine_gland0.70973761
87MP0000920_abnormal_myelination0.69056410
88MP0004043_abnormal_pH_regulation0.67617762
89MP0002090_abnormal_vision0.66939355
90MP0005171_absent_coat_pigmentation0.65873737
91MP0001177_atelectasis0.64164334
92MP0002638_abnormal_pupillary_reflex0.63216989
93MP0001765_abnormal_ion_homeostasis0.63138787
94MP0004215_abnormal_myocardial_fiber0.60992619
95MP0003137_abnormal_impulse_conducting0.60821754
96MP0005187_abnormal_penis_morphology0.59638669
97MP0005166_decreased_susceptibility_to0.59345959
98MP0005623_abnormal_meninges_morphology0.58341815
99MP0000026_abnormal_inner_ear0.57910720
100MP0004130_abnormal_muscle_cell0.55080923
101MP0001943_abnormal_respiration0.54595954
102MP0003283_abnormal_digestive_organ0.54554846
103MP0005379_endocrine/exocrine_gland_phen0.54507032
104MP0002163_abnormal_gland_morphology0.52403097
105MP0003121_genomic_imprinting0.51377556
106MP0010769_abnormal_survival0.51053873
107MP0003861_abnormal_nervous_system0.49853543
108MP0001346_abnormal_lacrimal_gland0.49791614
109MP0005410_abnormal_fertilization0.49368321
110MP0002653_abnormal_ependyma_morphology0.49161336
111MP0003956_abnormal_body_size0.48031002
112MP0010768_mortality/aging0.47861574
113MP0010234_abnormal_vibrissa_follicle0.46991682
114MP0003075_altered_response_to0.46931159
115MP0000569_abnormal_digit_pigmentation0.45411295
116MP0002082_postnatal_lethality0.44413754
117MP0010770_preweaning_lethality0.44413754

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.69501144
2Myokymia (HP:0002411)6.30738612
3Focal seizures (HP:0007359)5.65051509
4Visual hallucinations (HP:0002367)5.33890546
5Atonic seizures (HP:0010819)5.25415799
6Epileptic encephalopathy (HP:0200134)5.13271653
7Absence seizures (HP:0002121)4.59516564
8Febrile seizures (HP:0002373)4.50353790
9Hyperventilation (HP:0002883)4.23791429
10Dialeptic seizures (HP:0011146)4.21375135
11Progressive cerebellar ataxia (HP:0002073)3.98202920
12Generalized tonic-clonic seizures (HP:0002069)3.79422236
13Broad-based gait (HP:0002136)3.73589808
14Supranuclear gaze palsy (HP:0000605)3.58100260
15Cerebral inclusion bodies (HP:0100314)3.55792945
16Hemiplegia (HP:0002301)3.53887815
17Amblyopia (HP:0000646)3.45712478
18Action tremor (HP:0002345)3.22150962
19Neurofibrillary tangles (HP:0002185)3.18540821
20Poor eye contact (HP:0000817)3.07148368
21Truncal ataxia (HP:0002078)3.02531966
22Gaze-evoked nystagmus (HP:0000640)3.02530221
23Anxiety (HP:0000739)2.99170677
24Tetraplegia (HP:0002445)2.96800180
25Mutism (HP:0002300)2.94908147
26Insidious onset (HP:0003587)2.91485864
27Termporal pattern (HP:0011008)2.91485864
28Excessive salivation (HP:0003781)2.89603652
29Drooling (HP:0002307)2.89603652
30Cerebral hypomyelination (HP:0006808)2.85880438
31Status epilepticus (HP:0002133)2.85840120
32Dysmetria (HP:0001310)2.85384483
33Obstructive sleep apnea (HP:0002870)2.78753132
34Limb dystonia (HP:0002451)2.77927049
35Impaired vibration sensation in the lower limbs (HP:0002166)2.77539813
36Dysdiadochokinesis (HP:0002075)2.75345233
37Depression (HP:0000716)2.75233557
38Epileptiform EEG discharges (HP:0011182)2.72029889
39Progressive inability to walk (HP:0002505)2.71635087
40Urinary bladder sphincter dysfunction (HP:0002839)2.71110424
41Ankle clonus (HP:0011448)2.70466944
42Neuronal loss in central nervous system (HP:0002529)2.70022934
43Gait imbalance (HP:0002141)2.67723529
44Abnormal eating behavior (HP:0100738)2.66951829
45Diplopia (HP:0000651)2.66391396
46Abnormality of binocular vision (HP:0011514)2.66391396
47Abnormal social behavior (HP:0012433)2.65685145
48Impaired social interactions (HP:0000735)2.65685145
49Inability to walk (HP:0002540)2.62628648
50Abnormality of the corticospinal tract (HP:0002492)2.62357576
51Pheochromocytoma (HP:0002666)2.62065536
52Papilledema (HP:0001085)2.55450879
53EEG with generalized epileptiform discharges (HP:0011198)2.53786423
54Delusions (HP:0000746)2.49766773
55Annular pancreas (HP:0001734)2.45707409
56Absent speech (HP:0001344)2.45263107
57Sleep apnea (HP:0010535)2.39178427
58Neuroendocrine neoplasm (HP:0100634)2.38812052
59Polyphagia (HP:0002591)2.37851305
60Ventricular fibrillation (HP:0001663)2.36812843
61Hemiparesis (HP:0001269)2.35844503
62Acute necrotizing encephalopathy (HP:0006965)2.35635871
63Scanning speech (HP:0002168)2.34364857
64Stereotypic behavior (HP:0000733)2.33021882
65Retinal dysplasia (HP:0007973)2.32354019
66Hypsarrhythmia (HP:0002521)2.32339871
67Impaired smooth pursuit (HP:0007772)2.31012683
68Increased circulating renin level (HP:0000848)2.30565012
69Amyotrophic lateral sclerosis (HP:0007354)2.29772299
70Urinary urgency (HP:0000012)2.28633773
71Fetal akinesia sequence (HP:0001989)2.28539845
72Progressive macrocephaly (HP:0004481)2.27846000
73Clonus (HP:0002169)2.27179982
74Spastic gait (HP:0002064)2.26591837
75Rigidity (HP:0002063)2.22620153
76Medial flaring of the eyebrow (HP:0010747)2.19335278
77Generalized myoclonic seizures (HP:0002123)2.17571119
78Congenital primary aphakia (HP:0007707)2.17321400
79Bradykinesia (HP:0002067)2.14768673
80Genetic anticipation (HP:0003743)2.14491326
81Diminished motivation (HP:0000745)2.13992102
82Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.13926662
83Degeneration of the lateral corticospinal tracts (HP:0002314)2.13926662
84Torticollis (HP:0000473)2.13290087
85Peripheral hypomyelination (HP:0007182)2.12086309
86Spastic tetraparesis (HP:0001285)2.11850258
87Abnormal ciliary motility (HP:0012262)2.11526034
88Abnormal mitochondria in muscle tissue (HP:0008316)2.10911497
89Abnormality of salivation (HP:0100755)2.08992971
90Agitation (HP:0000713)2.08444016
91Focal dystonia (HP:0004373)2.06744185
92Akinesia (HP:0002304)2.06223513
93Morphological abnormality of the pyramidal tract (HP:0002062)2.05368223
94Absent/shortened dynein arms (HP:0200106)2.05209622
95Dynein arm defect of respiratory motile cilia (HP:0012255)2.05209622
96Postural instability (HP:0002172)2.02924828
97Abnormal respiratory motile cilium physiology (HP:0012261)2.02480877
98Protruding tongue (HP:0010808)2.01755335
99Inappropriate behavior (HP:0000719)2.01598816
100Hyperthyroidism (HP:0000836)2.00508994
101Lower limb muscle weakness (HP:0007340)2.00319329
102Bundle branch block (HP:0011710)1.97228440
103Abnormal respiratory motile cilium morphology (HP:0005938)1.95177263
104Abnormal respiratory epithelium morphology (HP:0012253)1.95177263
105Psychosis (HP:0000709)1.94739176
106Megalencephaly (HP:0001355)1.94250934
107Split foot (HP:0001839)1.94248836
108Nephrogenic diabetes insipidus (HP:0009806)1.94246831
109Blue irides (HP:0000635)1.93892650
110Incomplete penetrance (HP:0003829)1.93482575
111Memory impairment (HP:0002354)1.89989455
112Mitochondrial inheritance (HP:0001427)1.89612357
113Abnormality of ocular smooth pursuit (HP:0000617)1.89423949
114Impaired vibratory sensation (HP:0002495)1.88307512
115Specific learning disability (HP:0001328)1.87943562
116Craniofacial dystonia (HP:0012179)1.86361236
117Intention tremor (HP:0002080)1.86045223
118Choreoathetosis (HP:0001266)1.85805109
119CNS hypomyelination (HP:0003429)1.85422931
120Prolonged QT interval (HP:0001657)1.83916224
121Abnormality of the lower motor neuron (HP:0002366)1.82878425
122Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.82618063
123Apathy (HP:0000741)1.82613829
124Rapidly progressive (HP:0003678)1.82442624
125Genital tract atresia (HP:0001827)1.82155881

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.14661084
2NTRK34.07517193
3MAP3K93.54274501
4MARK13.32377337
5MAP3K43.09039601
6MAP3K123.01327617
7CASK3.01021487
8MAP2K72.86658894
9MINK12.75773819
10RIPK42.71425792
11DAPK22.38222014
12PNCK2.23716820
13PLK22.18171187
14ARAF2.01450689
15GRK51.96023790
16MAP2K41.93969535
17KSR21.89408752
18NTRK11.85828429
19DAPK11.82497768
20NTRK21.66837268
21PINK11.66279725
22PAK61.60583338
23KSR11.59220963
24CDK191.56456992
25CDK51.42490704
26MAPK131.39235375
27BMPR21.34359197
28NME11.34347205
29TNIK1.32848810
30RIPK11.27490213
31PRKCG1.23606078
32PTK2B1.23434576
33CAMKK11.22868783
34FES1.18189954
35SIK21.15106060
36TESK11.14871630
37MAP3K21.14568626
38CAMK2A1.14102555
39LIMK11.13926663
40CAMKK21.12962471
41PRPF4B1.10112311
42OXSR11.06782306
43FGR1.05804120
44MAP3K131.03840356
45CAMK2B1.03555300
46PHKG20.97773227
47PHKG10.97773227
48RAF10.93344722
49CDK140.91363662
50LATS20.88960223
51CDK180.87988016
52NEK60.86144392
53UHMK10.83131971
54CDK150.83092573
55PRKD30.83014210
56BCR0.81336752
57CCNB10.77416047
58CSNK1G20.76068595
59DYRK1A0.75445714
60PAK30.75148920
61GRK70.74977554
62CDK11A0.72317014
63PRKCE0.71377643
64SGK30.70425748
65CAMK2D0.65813966
66STK380.64986211
67STK110.64045123
68SGK2230.62558529
69SGK4940.62558529
70RET0.61798722
71SIK30.61795321
72TYRO30.60766966
73ALK0.57197544
74GRK60.57033703
75FER0.56333209
76SGK10.54727774
77BRAF0.54360046
78CAMK40.54317963
79CAMK10.54114680
80MAPK100.53668785
81STK390.53410969
82CAMK2G0.51328384
83MAP3K60.50772155
84DAPK30.47662336
85PRKCZ0.47466102
86ADRBK10.47183737
87MAPK150.47069052
88ROCK20.46033014
89MAP2K10.46006864
90MAP3K110.44564207
91FYN0.44224665
92AKT30.42155697
93PRKCA0.41878791
94PDPK10.41680122
95MAP3K10.41218579
96MARK20.40790811
97SGK20.40097154
98PRKG10.39399117
99PDK10.39376986
100ROCK10.39161306
101CSNK1A1L0.38390385
102MAPK120.37711345
103MOS0.37044968
104MAP2K60.36854042
105PRKCH0.36705640
106FGFR20.36557297
107PKN10.34136465
108TNK20.32929021
109CSNK1G30.31674014
110SCYL20.31434495
111PRKACA0.31249331
112ADRBK20.30809548
113RPS6KA30.30689392
114CSNK1D0.30133720
115ERBB30.30085439
116DYRK20.29216373
117WNK30.29159910
118PRKCB0.28596469
119TAOK10.28038788
120ERBB20.27841064

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.83754625
2Synaptic vesicle cycle_Homo sapiens_hsa047213.40424812
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.87109892
4* Olfactory transduction_Homo sapiens_hsa047402.82649007
5* Long-term potentiation_Homo sapiens_hsa047202.72540655
6GABAergic synapse_Homo sapiens_hsa047272.61087540
7* Circadian entrainment_Homo sapiens_hsa047132.57855055
8Glutamatergic synapse_Homo sapiens_hsa047242.56092021
9Morphine addiction_Homo sapiens_hsa050322.53618290
10Collecting duct acid secretion_Homo sapiens_hsa049662.38834710
11* Amphetamine addiction_Homo sapiens_hsa050312.38193755
12* Dopaminergic synapse_Homo sapiens_hsa047282.21281665
13* Salivary secretion_Homo sapiens_hsa049702.05826590
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.04934046
15Taste transduction_Homo sapiens_hsa047422.02478405
16Serotonergic synapse_Homo sapiens_hsa047261.91337230
17Oxidative phosphorylation_Homo sapiens_hsa001901.90568752
18Cholinergic synapse_Homo sapiens_hsa047251.88977106
19Insulin secretion_Homo sapiens_hsa049111.84970465
20Long-term depression_Homo sapiens_hsa047301.81600047
21* Renin secretion_Homo sapiens_hsa049241.80050862
22* Gastric acid secretion_Homo sapiens_hsa049711.73988922
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63517994
24* Oxytocin signaling pathway_Homo sapiens_hsa049211.59849852
25Vibrio cholerae infection_Homo sapiens_hsa051101.55862604
26Alzheimers disease_Homo sapiens_hsa050101.55310178
27* Calcium signaling pathway_Homo sapiens_hsa040201.53841723
28* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53622951
29Cocaine addiction_Homo sapiens_hsa050301.48565649
30Parkinsons disease_Homo sapiens_hsa050121.47200254
31* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43952348
32Cardiac muscle contraction_Homo sapiens_hsa042601.41840605
33Gap junction_Homo sapiens_hsa045401.34299143
34* GnRH signaling pathway_Homo sapiens_hsa049121.32972607
35* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25699221
36Axon guidance_Homo sapiens_hsa043601.18005343
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16859428
38* cAMP signaling pathway_Homo sapiens_hsa040241.12740999
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10865922
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08835720
41Huntingtons disease_Homo sapiens_hsa050161.06175659
42* Estrogen signaling pathway_Homo sapiens_hsa049151.05396458
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96675153
44* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95691766
45Vitamin B6 metabolism_Homo sapiens_hsa007500.95222555
46* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94555245
47* Melanogenesis_Homo sapiens_hsa049160.94022943
48ErbB signaling pathway_Homo sapiens_hsa040120.90869249
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88500664
50* Vascular smooth muscle contraction_Homo sapiens_hsa042700.88356092
51* Glioma_Homo sapiens_hsa052140.84720962
52Pancreatic secretion_Homo sapiens_hsa049720.84283725
53* Oocyte meiosis_Homo sapiens_hsa041140.82648524
54Type II diabetes mellitus_Homo sapiens_hsa049300.82634206
55* Phototransduction_Homo sapiens_hsa047440.81705262
56Bile secretion_Homo sapiens_hsa049760.76324153
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73480724
58Dorso-ventral axis formation_Homo sapiens_hsa043200.71096477
59Thyroid hormone synthesis_Homo sapiens_hsa049180.69871062
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69768595
61Rheumatoid arthritis_Homo sapiens_hsa053230.66786045
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66404322
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.65404034
64VEGF signaling pathway_Homo sapiens_hsa043700.63834811
65African trypanosomiasis_Homo sapiens_hsa051430.61117920
66MAPK signaling pathway_Homo sapiens_hsa040100.60921238
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60692669
68Choline metabolism in cancer_Homo sapiens_hsa052310.58922431
69Type I diabetes mellitus_Homo sapiens_hsa049400.57721243
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.56197904
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55446729
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55295168
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55002153
74* Ras signaling pathway_Homo sapiens_hsa040140.53692691
75Dilated cardiomyopathy_Homo sapiens_hsa054140.53094652
76Mineral absorption_Homo sapiens_hsa049780.52476317
77* Alcoholism_Homo sapiens_hsa050340.50379616
78Histidine metabolism_Homo sapiens_hsa003400.48476245
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48374335
80Regulation of autophagy_Homo sapiens_hsa041400.46810622
81beta-Alanine metabolism_Homo sapiens_hsa004100.42279476
82Phagosome_Homo sapiens_hsa041450.42236257
83* Neurotrophin signaling pathway_Homo sapiens_hsa047220.42226361
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40895264
85* Rap1 signaling pathway_Homo sapiens_hsa040150.40234368
86Prion diseases_Homo sapiens_hsa050200.40165545
87* Glucagon signaling pathway_Homo sapiens_hsa049220.40029170
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38962211
89Renal cell carcinoma_Homo sapiens_hsa052110.38861285
90Inositol phosphate metabolism_Homo sapiens_hsa005620.38360082
91Endocytosis_Homo sapiens_hsa041440.37573403
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37343319
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36980739
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35638223
95Wnt signaling pathway_Homo sapiens_hsa043100.34530740
96Tight junction_Homo sapiens_hsa045300.33787849
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33486013
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32138203
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31431342
100Chemokine signaling pathway_Homo sapiens_hsa040620.31419996
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30883898
102Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29130319
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29017519
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27651808
105Ovarian steroidogenesis_Homo sapiens_hsa049130.26867685
106Circadian rhythm_Homo sapiens_hsa047100.25846836
107Salmonella infection_Homo sapiens_hsa051320.25660052
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23377154
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22873344
110Nitrogen metabolism_Homo sapiens_hsa009100.22448513
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.22328429
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21902892
113Endometrial cancer_Homo sapiens_hsa052130.21713728
114Arginine and proline metabolism_Homo sapiens_hsa003300.19934186
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19882675
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.18623147
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.16850112

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