ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein neddylation (GO:0045116)	6.43017553
2	ribosomal small subunit assembly (GO:0000028)	6.36604419
3	ATP synthesis coupled proton transport (GO:0015986)	5.71555867
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.71555867
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.51883196
6	DNA deamination (GO:0045006)	5.43916198
7	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	5.39398245
8	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	5.39398245
9	behavioral response to nicotine (GO:0035095)	5.02492998
10	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.85898388
11	chaperone-mediated protein transport (GO:0072321)	4.71540180
12	protein-cofactor linkage (GO:0018065)	4.33385358
13	respiratory electron transport chain (GO:0022904)	4.29416521
14	electron transport chain (GO:0022900)	4.20555507
15	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.17132624
16	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.06302679
17	substrate-independent telencephalic tangential migration (GO:0021826)	4.06302679
18	nonmotile primary cilium assembly (GO:0035058)	4.04420067
19	peptidyl-threonine dephosphorylation (GO:0035970)	4.00921057
20	hydrogen ion transmembrane transport (GO:1902600)	3.93033279
21	cellular ketone body metabolic process (GO:0046950)	3.79504106
22	negative regulation of telomere maintenance (GO:0032205)	3.77167262
23	aldehyde catabolic process (GO:0046185)	3.62135110
24	platelet dense granule organization (GO:0060155)	3.55660718
25	regulation of cilium movement (GO:0003352)	3.53048111
26	proton transport (GO:0015992)	3.45466065
27	GTP biosynthetic process (GO:0006183)	3.45042891
28	base-excision repair, AP site formation (GO:0006285)	3.44433655
29	hydrogen transport (GO:0006818)	3.39825746
30	ketone body metabolic process (GO:1902224)	3.37470130
31	viral transcription (GO:0019083)	3.37048884
32	cellular response to interleukin-15 (GO:0071350)	3.30133150
33	regulation of cellular respiration (GO:0043457)	3.29229729
34	translational termination (GO:0006415)	3.28007009
35	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.27449631
36	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.26923887
37	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.25458244
38	maturation of SSU-rRNA (GO:0030490)	3.23186873
39	protein peptidyl-prolyl isomerization (GO:0000413)	3.22793103
40	ATP biosynthetic process (GO:0006754)	3.21893864
41	protein complex biogenesis (GO:0070271)	3.19596535
42	ribosomal large subunit biogenesis (GO:0042273)	3.19529330
43	protein localization to endoplasmic reticulum (GO:0070972)	3.17704172
44	ncRNA 3-end processing (GO:0043628)	3.16703362
45	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.13759163
46	protein targeting to ER (GO:0045047)	3.10011905
47	cotranslational protein targeting to membrane (GO:0006613)	3.08714559
48	regulation of microtubule-based movement (GO:0060632)	3.07078002
49	left/right axis specification (GO:0070986)	3.06441473
50	positive regulation of sodium ion transmembrane transport (GO:1902307)	3.03418261
51	signal peptide processing (GO:0006465)	3.02344231
52	translational elongation (GO:0006414)	2.99355621
53	cytidine metabolic process (GO:0046087)	2.96679592
54	cytidine catabolic process (GO:0006216)	2.96679592
55	cytidine deamination (GO:0009972)	2.96679592
56	neurofilament cytoskeleton organization (GO:0060052)	2.96619509
57	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.91418164
58	protein polyglutamylation (GO:0018095)	2.91097718
59	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.90391440
60	tRNA processing (GO:0008033)	2.90040719
61	neuronal action potential propagation (GO:0019227)	2.87657711
62	heart contraction (GO:0060047)	2.84970776
63	heart process (GO:0003015)	2.84970776
64	respiratory chain complex IV assembly (GO:0008535)	2.83998420
65	GPI anchor metabolic process (GO:0006505)	2.82107685
66	retinal cone cell development (GO:0046549)	2.79706658
67	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.76554308
68	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.76138147
69	termination of RNA polymerase III transcription (GO:0006386)	2.76138147
70	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.75936287
71	NADH dehydrogenase complex assembly (GO:0010257)	2.75936287
72	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.75936287
73	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.75824183
74	positive regulation of growth hormone secretion (GO:0060124)	2.74680206
75	mitochondrial respiratory chain complex assembly (GO:0033108)	2.73682961
76	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.72835844
77	UTP biosynthetic process (GO:0006228)	2.71664339
78	water-soluble vitamin biosynthetic process (GO:0042364)	2.70383005
79	GPI anchor biosynthetic process (GO:0006506)	2.69350327
80	somite development (GO:0061053)	2.68796168
81	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.63769806
82	pyrimidine nucleobase catabolic process (GO:0006208)	2.62401132
83	parturition (GO:0007567)	2.61268027
84	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.58984293
85	UTP metabolic process (GO:0046051)	2.57145141
86	growth hormone secretion (GO:0030252)	2.55629629
87	viral life cycle (GO:0019058)	2.54116469
88	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.51076190
89	cytochrome complex assembly (GO:0017004)	2.50431111
90	positive regulation of humoral immune response (GO:0002922)	2.48683871
91	phenylpropanoid metabolic process (GO:0009698)	2.48568011
92	synaptic transmission, cholinergic (GO:0007271)	2.48518328
93	peptidyl-histidine modification (GO:0018202)	2.47923319
94	positive regulation of mitochondrial fission (GO:0090141)	2.47464508
95	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.47326693
96	translation (GO:0006412)	2.44695452
97	cellular protein complex disassembly (GO:0043624)	2.44045833
98	axoneme assembly (GO:0035082)	2.43899131
99	deoxyribonucleotide catabolic process (GO:0009264)	2.43833270
100	negative regulation of systemic arterial blood pressure (GO:0003085)	2.42931730

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.88372017
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.39209228
3	VDR_22108803_ChIP-Seq_LS180_Human	3.18317987
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.08569791
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.06038226
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.82958105
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.53037597
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.34254594
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.33428441
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.31707784
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.27898901
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.19716311
13	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.17693454
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.13343019
15	IRF1_19129219_ChIP-ChIP_H3396_Human	1.91130616
16	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.82978489
17	TP53_22573176_ChIP-Seq_HFKS_Human	1.81721772
18	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.76468263
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.74963720
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.73027235
21	MYC_18940864_ChIP-ChIP_HL60_Human	1.71536701
22	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.71291390
23	VDR_23849224_ChIP-Seq_CD4+_Human	1.68788667
24	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.68252396
25	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.66829596
26	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.62473869
27	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.61802470
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.59846681
29	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.51167537
30	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.49685113
31	NCOR_22424771_ChIP-Seq_293T_Human	1.47084152
32	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.43879817
33	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.43879817
34	FOXP3_21729870_ChIP-Seq_TREG_Human	1.42500108
35	ELK1_19687146_ChIP-ChIP_HELA_Human	1.39287886
36	REST_21632747_ChIP-Seq_MESCs_Mouse	1.38519541
37	HTT_18923047_ChIP-ChIP_STHdh_Human	1.37402897
38	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.36690529
39	ER_23166858_ChIP-Seq_MCF-7_Human	1.35364419
40	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.34941653
41	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.32421106
42	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.31994374
43	P300_19829295_ChIP-Seq_ESCs_Human	1.31462969
44	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.27894946
45	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.24511782
46	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.22870141
47	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.22487136
48	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.20202884
49	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.18927600
50	NANOG_20526341_ChIP-Seq_ESCs_Human	1.17740285
51	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.17641807
52	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.17596715
53	EWS_26573619_Chip-Seq_HEK293_Human	1.17268505
54	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.16979569
55	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.16399944
56	MYC_19829295_ChIP-Seq_ESCs_Human	1.16118779
57	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.15464451
58	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.15343545
59	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.12791037
60	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.12466429
61	BCAT_22108803_ChIP-Seq_LS180_Human	1.12170711
62	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.11400197
63	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.10821567
64	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10034755
65	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.09710114
66	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.09406967
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.09340306
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.09340306
69	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.07421389
70	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.07205917
71	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.06115014
72	CBP_20019798_ChIP-Seq_JUKART_Human	1.06115014
73	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.05461196
74	RNF2_27304074_Chip-Seq_NSC_Mouse	1.04913739
75	AR_20517297_ChIP-Seq_VCAP_Human	1.03291558
76	TCF4_22108803_ChIP-Seq_LS180_Human	1.03232195
77	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02677753
78	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.00507459
79	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.00100094
80	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.98565475
81	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.98225380
82	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.98033573
83	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.97694043
84	AR_21572438_ChIP-Seq_LNCaP_Human	0.97616921
85	GABP_19822575_ChIP-Seq_HepG2_Human	0.97205010
86	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.96755092
87	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.95053137
88	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.92255129
89	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.90261279
90	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.90091463
91	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.89983532
92	TTF2_22483619_ChIP-Seq_HELA_Human	0.89585262
93	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.89340665
94	TAF2_19829295_ChIP-Seq_ESCs_Human	0.89293725
95	FUS_26573619_Chip-Seq_HEK293_Human	0.89081740
96	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.88954373
97	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.88813887
98	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.88434445
99	HOXB7_26014856_ChIP-Seq_BT474_Human	0.87604774
100	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.87587094

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	3.89424130
2	MP0006292_abnormal_olfactory_placode	2.86772979
3	MP0001968_abnormal_touch/_nociception	2.58590731
4	MP0002736_abnormal_nociception_after	2.57278253
5	MP0008877_abnormal_DNA_methylation	2.44993825
6	MP0004145_abnormal_muscle_electrophysio	2.32221798
7	MP0003880_abnormal_central_pattern	2.27691181
8	MP0002163_abnormal_gland_morphology	2.23739799
9	MP0006276_abnormal_autonomic_nervous	2.23291356
10	MP0003122_maternal_imprinting	2.17106114
11	MP0005671_abnormal_response_to	2.16783355
12	MP0003011_delayed_dark_adaptation	2.10951330
13	MP0002272_abnormal_nervous_system	2.09857038
14	MP0004142_abnormal_muscle_tone	2.06760510
15	MP0004885_abnormal_endolymph	2.00464672
16	MP0005379_endocrine/exocrine_gland_phen	1.92224564
17	MP0005551_abnormal_eye_electrophysiolog	1.88375543
18	MP0006072_abnormal_retinal_apoptosis	1.79260101
19	MP0004043_abnormal_pH_regulation	1.77487392
20	MP0009379_abnormal_foot_pigmentation	1.77146891
21	MP0001501_abnormal_sleep_pattern	1.76889225
22	MP0009745_abnormal_behavioral_response	1.76206657
23	MP0004742_abnormal_vestibular_system	1.71098733
24	MP0002876_abnormal_thyroid_physiology	1.67450522
25	MP0001986_abnormal_taste_sensitivity	1.64496919
26	MP0008789_abnormal_olfactory_epithelium	1.63988465
27	MP0001984_abnormal_olfaction	1.62073940
28	MP0003121_genomic_imprinting	1.60321738
29	MP0002733_abnormal_thermal_nociception	1.59815819
30	MP0001970_abnormal_pain_threshold	1.56824491
31	MP0001440_abnormal_grooming_behavior	1.51525988
32	MP0003635_abnormal_synaptic_transmissio	1.49570680
33	MP0008058_abnormal_DNA_repair	1.49163398
34	MP0008872_abnormal_physiological_respon	1.46336961
35	MP0004147_increased_porphyrin_level	1.46262881
36	MP0001905_abnormal_dopamine_level	1.45395119
37	MP0005499_abnormal_olfactory_system	1.44872829
38	MP0005394_taste/olfaction_phenotype	1.44872829
39	MP0005645_abnormal_hypothalamus_physiol	1.42096379
40	MP0002102_abnormal_ear_morphology	1.38688764
41	MP0005083_abnormal_biliary_tract	1.36939454
42	MP0002638_abnormal_pupillary_reflex	1.35291181
43	MP0009046_muscle_twitch	1.33394003
44	MP0005167_abnormal_blood-brain_barrier	1.33079389
45	MP0005253_abnormal_eye_physiology	1.32615219
46	MP0005085_abnormal_gallbladder_physiolo	1.31608112
47	MP0001502_abnormal_circadian_rhythm	1.31378124
48	MP0005389_reproductive_system_phenotype	1.30418050
49	MP0002160_abnormal_reproductive_system	1.29914415
50	MP0002557_abnormal_social/conspecific_i	1.29438129
51	MP0001486_abnormal_startle_reflex	1.24478328
52	MP0003866_abnormal_defecation	1.24460119
53	MP0003646_muscle_fatigue	1.23930287
54	MP0002572_abnormal_emotion/affect_behav	1.23804002
55	MP0008569_lethality_at_weaning	1.22569554
56	MP0002067_abnormal_sensory_capabilities	1.22110981
57	MP0002735_abnormal_chemical_nociception	1.20746879
58	MP0002734_abnormal_mechanical_nocicepti	1.18082011
59	MP0002063_abnormal_learning/memory/cond	1.17325229
60	MP0001529_abnormal_vocalization	1.15922195
61	MP0005174_abnormal_tail_pigmentation	1.15853876
62	MP0002064_seizures	1.15279957
63	MP0002184_abnormal_innervation	1.12776200
64	MP0001485_abnormal_pinna_reflex	1.12693382
65	MP0000749_muscle_degeneration	1.12269318
66	MP0005075_abnormal_melanosome_morpholog	1.08909124
67	MP0002095_abnormal_skin_pigmentation	1.07683294
68	MP0001919_abnormal_reproductive_system	1.07545159
69	MP0000955_abnormal_spinal_cord	1.06603604
70	MP0003724_increased_susceptibility_to	1.04893661
71	MP0005423_abnormal_somatic_nervous	1.02452562
72	MP0010386_abnormal_urinary_bladder	1.01258905
73	MP0000230_abnormal_systemic_arterial	1.01198123
74	MP0005636_abnormal_mineral_homeostasis	1.00416470
75	MP0002752_abnormal_somatic_nervous	0.99956739
76	MP0001765_abnormal_ion_homeostasis	0.99711908
77	MP0002229_neurodegeneration	0.99563023
78	MP0003186_abnormal_redox_activity	0.95998038
79	MP0000372_irregular_coat_pigmentation	0.95945988
80	MP0002234_abnormal_pharynx_morphology	0.94658414
81	MP0008875_abnormal_xenobiotic_pharmacok	0.93900438
82	MP0000639_abnormal_adrenal_gland	0.93443001
83	MP0001756_abnormal_urination	0.92909174
84	MP0004215_abnormal_myocardial_fiber	0.92883196
85	MP0004019_abnormal_vitamin_homeostasis	0.88475040
86	MP0000778_abnormal_nervous_system	0.87216645
87	MP0005377_hearing/vestibular/ear_phenot	0.83431166
88	MP0003878_abnormal_ear_physiology	0.83431166
89	MP0003718_maternal_effect	0.82818168
90	MP0003123_paternal_imprinting	0.82783012
91	MP0005084_abnormal_gallbladder_morpholo	0.81464884
92	MP0002254_reproductive_system_inflammat	0.80346713
93	MP0002090_abnormal_vision	0.79953828
94	MP0003137_abnormal_impulse_conducting	0.79805189
95	MP0000026_abnormal_inner_ear	0.78557771
96	MP0005195_abnormal_posterior_eye	0.77417009
97	MP0004133_heterotaxia	0.76716253
98	MP0002837_dystrophic_cardiac_calcinosis	0.76668625
99	MP0001881_abnormal_mammary_gland	0.75064650
100	MP0004270_analgesia	0.74734278

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.58386541
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.13899261
3	Acute encephalopathy (HP:0006846)	4.05195188
4	Reticulocytopenia (HP:0001896)	4.03401270
5	Progressive macrocephaly (HP:0004481)	3.69178336
6	Mitochondrial inheritance (HP:0001427)	3.41625512
7	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.32815991
8	Abnormality of alanine metabolism (HP:0010916)	3.32815991
9	Hyperalaninemia (HP:0003348)	3.32815991
10	Hepatocellular necrosis (HP:0001404)	3.27138153
11	3-Methylglutaconic aciduria (HP:0003535)	3.21709138
12	Increased CSF lactate (HP:0002490)	3.04404909
13	Metabolic alkalosis (HP:0200114)	3.01555104
14	Molar tooth sign on MRI (HP:0002419)	2.93998425
15	Abnormality of midbrain morphology (HP:0002418)	2.93998425
16	Pancreatic cysts (HP:0001737)	2.93593338
17	Pendular nystagmus (HP:0012043)	2.88932520
18	Optic disc pallor (HP:0000543)	2.84549382
19	Hepatic necrosis (HP:0002605)	2.82983127
20	Abnormality of cells of the erythroid lineage (HP:0012130)	2.82851498
21	Pancreatic fibrosis (HP:0100732)	2.79764824
22	Cerebral edema (HP:0002181)	2.75679355
23	Abolished electroretinogram (ERG) (HP:0000550)	2.75587479
24	Impulsivity (HP:0100710)	2.73608052
25	Increased corneal curvature (HP:0100692)	2.71880801
26	Keratoconus (HP:0000563)	2.71880801
27	Agitation (HP:0000713)	2.70732373
28	Hypomagnesemia (HP:0002917)	2.67788042
29	Broad alveolar ridges (HP:0000187)	2.66644921
30	Hypokalemic alkalosis (HP:0001949)	2.66555117
31	Hyperglycinemia (HP:0002154)	2.59098400
32	Type 2 muscle fiber atrophy (HP:0003554)	2.54166573
33	Progressive cerebellar ataxia (HP:0002073)	2.53765096
34	Polyuria (HP:0000103)	2.53362116
35	Abnormal number of erythroid precursors (HP:0012131)	2.51792066
36	Abnormality of magnesium homeostasis (HP:0004921)	2.51494825
37	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.50568571
38	Increased circulating renin level (HP:0000848)	2.47393257
39	Reduced antithrombin III activity (HP:0001976)	2.38989937
40	Sclerocornea (HP:0000647)	2.36199220
41	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.34664652
42	Myokymia (HP:0002411)	2.32310360
43	Medial flaring of the eyebrow (HP:0010747)	2.29318924
44	Muscle fiber atrophy (HP:0100295)	2.21751402
45	Increased serum lactate (HP:0002151)	2.21532340
46	Renal salt wasting (HP:0000127)	2.13797498
47	Hyperaldosteronism (HP:0000859)	2.13575335
48	Colon cancer (HP:0003003)	2.13475825
49	Restlessness (HP:0000711)	2.12204452
50	Abnormality of the renal cortex (HP:0011035)	2.11622237
51	Congenital stationary night blindness (HP:0007642)	2.10888841
52	Inability to walk (HP:0002540)	2.10554660
53	Respiratory failure (HP:0002878)	2.10205733
54	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.09631998
55	Abnormal protein N-linked glycosylation (HP:0012347)	2.09631998
56	Abnormal protein glycosylation (HP:0012346)	2.09631998
57	Abnormal glycosylation (HP:0012345)	2.09631998
58	Alkalosis (HP:0001948)	2.09598523
59	True hermaphroditism (HP:0010459)	2.08937133
60	Lactic acidosis (HP:0003128)	2.08069200
61	Gait imbalance (HP:0002141)	2.07445895
62	Focal seizures (HP:0007359)	2.06122257
63	Abnormality of serum amino acid levels (HP:0003112)	2.03049992
64	Chorioretinal atrophy (HP:0000533)	2.02811397
65	Abnormal urine output (HP:0012590)	2.02626195
66	Abnormal rod and cone electroretinograms (HP:0008323)	2.02246747
67	Abnormality of the renal medulla (HP:0100957)	2.01308158
68	Septo-optic dysplasia (HP:0100842)	2.00510086
69	Pallor (HP:0000980)	1.98841776
70	Severe visual impairment (HP:0001141)	1.98340428
71	Lethargy (HP:0001254)	1.95084814
72	Neonatal respiratory distress (HP:0002643)	1.92638235
73	Fetal akinesia sequence (HP:0001989)	1.90135450
74	Leukodystrophy (HP:0002415)	1.90086769
75	IgG deficiency (HP:0004315)	1.88878238
76	Methylmalonic aciduria (HP:0012120)	1.88458303
77	Absent thumb (HP:0009777)	1.88306879
78	Polydipsia (HP:0001959)	1.87381729
79	Abnormal drinking behavior (HP:0030082)	1.87381729
80	B lymphocytopenia (HP:0010976)	1.85747956
81	Congenital primary aphakia (HP:0007707)	1.85019179
82	X-linked dominant inheritance (HP:0001423)	1.84293603
83	Macrocytic anemia (HP:0001972)	1.84048525
84	Severe global developmental delay (HP:0011344)	1.83968206
85	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.83822577
86	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.83822577
87	Poor suck (HP:0002033)	1.83247190
88	Nephronophthisis (HP:0000090)	1.82221716
89	Abnormality of the anterior horn cell (HP:0006802)	1.81990669
90	Degeneration of anterior horn cells (HP:0002398)	1.81990669
91	Volvulus (HP:0002580)	1.81403814
92	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.80374873
93	Abnormality of chloride homeostasis (HP:0011422)	1.78734007
94	Abnormality of renal excretion (HP:0011036)	1.78733544
95	Hyperglycinuria (HP:0003108)	1.76953431
96	Tetany (HP:0001281)	1.76828318
97	Abnormal hair whorl (HP:0010721)	1.76761921
98	Congenital, generalized hypertrichosis (HP:0004540)	1.75235800
99	Abnormality of B cell number (HP:0010975)	1.73509965
100	Type II lissencephaly (HP:0007260)	1.73323964

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	3.48868562
2	TIE1	3.36791446
3	TXK	3.30797594
4	MAP4K2	3.26083216
5	MAP3K12	2.54259138
6	TLK1	2.36024886
7	BCKDK	2.29251156
8	WNK3	1.88424842
9	GRK1	1.86879933
10	TEC	1.84663245
11	ZAK	1.82761902
12	BMPR1B	1.79127423
13	ADRBK2	1.72621653
14	STK39	1.68538047
15	MARK1	1.65461727
16	ERBB3	1.60426075
17	EPHA4	1.55528717
18	MST4	1.51335427
19	NEK1	1.50616905
20	TAOK3	1.41400338
21	NME1	1.40613388
22	PDK2	1.38553785
23	ITK	1.35231276
24	BCR	1.33621321
25	MINK1	1.31554104
26	PINK1	1.28801272
27	RPS6KA4	1.28418324
28	BTK	1.24600158
29	EPHB2	1.24568587
30	MYLK	1.24390191
31	PLK2	1.22734048
32	LIMK1	1.16508385
33	CDK19	1.14898303
34	OBSCN	1.12320850
35	PIK3CA	1.07976563
36	OXSR1	1.06127997
37	SCYL2	1.05361121
38	CSNK1G2	1.03295622
39	PHKG1	1.01261167
40	PHKG2	1.01261167
41	MAP2K2	0.98364697
42	SYK	0.93763495
43	MARK2	0.91417309
44	INSRR	0.90971380
45	KDR	0.90799396
46	CSNK1G3	0.90004006
47	FRK	0.87038130
48	CSNK1G1	0.86452169
49	PASK	0.84398317
50	SGK494	0.80079333
51	SGK223	0.80079333
52	MUSK	0.78644970
53	NTRK2	0.76836963
54	WNK1	0.75249792
55	CAMK2A	0.75009875
56	MAPKAPK3	0.74657677
57	DYRK2	0.73967920
58	TRIM28	0.73677596
59	BUB1	0.73000594
60	CAMK1	0.72777024
61	ILK	0.72241380
62	MAPK13	0.72073994
63	PRKACA	0.71951494
64	NLK	0.71595984
65	CAMK2D	0.71493849
66	PAK3	0.70779041
67	PRKCQ	0.64589161
68	MAP3K9	0.63960191
69	CSNK1D	0.63266941
70	PRKCG	0.63190395
71	SGK2	0.60895790
72	DYRK3	0.59447984
73	FLT3	0.58811807
74	MAP2K6	0.58602906
75	FES	0.57824129
76	CSNK1A1L	0.57439641
77	GRK5	0.57106276
78	DAPK3	0.56853944
79	ADRBK1	0.53796971
80	DAPK1	0.52372966
81	PRKCA	0.51156463
82	RPS6KA5	0.50713903
83	STK11	0.49876675
84	MAP2K1	0.49707498
85	LYN	0.48976907
86	MAP3K11	0.48300653
87	NUAK1	0.47316679
88	NTRK1	0.43160549
89	MAP3K13	0.42442129
90	IGF1R	0.42186352
91	CSNK2A1	0.42003612
92	CSNK2A2	0.41999974
93	IKBKB	0.41176190
94	CASK	0.40818269
95	CAMK4	0.40715537
96	GRK6	0.39813308
97	PRKG1	0.39625373
98	ROCK1	0.38858052
99	VRK1	0.38191224
100	MATK	0.36828543

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.62036553
2	Parkinsons disease_Homo sapiens_hsa05012	3.68832884
3	Ribosome_Homo sapiens_hsa03010	3.39202962
4	Cardiac muscle contraction_Homo sapiens_hsa04260	3.14675775
5	Alzheimers disease_Homo sapiens_hsa05010	2.73845110
6	Protein export_Homo sapiens_hsa03060	2.65942423
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.53855085
8	Huntingtons disease_Homo sapiens_hsa05016	2.43692372
9	Proteasome_Homo sapiens_hsa03050	2.43004668
10	Peroxisome_Homo sapiens_hsa04146	2.22052129
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.18172079
12	RNA polymerase_Homo sapiens_hsa03020	2.16459374
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.97434568
14	Phototransduction_Homo sapiens_hsa04744	1.80448297
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.76783123
16	Propanoate metabolism_Homo sapiens_hsa00640	1.56221328
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.46316436
18	RNA degradation_Homo sapiens_hsa03018	1.37630307
19	Butanoate metabolism_Homo sapiens_hsa00650	1.37472885
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.36398377
21	Type I diabetes mellitus_Homo sapiens_hsa04940	1.35991541
22	Primary immunodeficiency_Homo sapiens_hsa05340	1.31763815
23	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.30986169
24	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.29765876
25	Retinol metabolism_Homo sapiens_hsa00830	1.29484629
26	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.28010381
27	Fatty acid elongation_Homo sapiens_hsa00062	1.25829272
28	Asthma_Homo sapiens_hsa05310	1.21245629
29	Regulation of autophagy_Homo sapiens_hsa04140	1.21150336
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.20205036
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.18359885
32	Collecting duct acid secretion_Homo sapiens_hsa04966	1.15820618
33	Mismatch repair_Homo sapiens_hsa03430	1.14797592
34	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.11033241
35	Folate biosynthesis_Homo sapiens_hsa00790	1.10795060
36	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.10051479
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.05627304
38	Chemical carcinogenesis_Homo sapiens_hsa05204	1.05182103
39	Nicotine addiction_Homo sapiens_hsa05033	1.02849994
40	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.01787221
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.01774833
42	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.01286583
43	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.96200113
44	Olfactory transduction_Homo sapiens_hsa04740	0.96127961
45	Allograft rejection_Homo sapiens_hsa05330	0.93950666
46	Steroid biosynthesis_Homo sapiens_hsa00100	0.93911176
47	One carbon pool by folate_Homo sapiens_hsa00670	0.93376542
48	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.91901383
49	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.91154190
50	Fanconi anemia pathway_Homo sapiens_hsa03460	0.90339239
51	Linoleic acid metabolism_Homo sapiens_hsa00591	0.87465848
52	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.87064565
53	Morphine addiction_Homo sapiens_hsa05032	0.85188869
54	Taste transduction_Homo sapiens_hsa04742	0.84394347
55	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.83832074
56	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.82940854
57	Graft-versus-host disease_Homo sapiens_hsa05332	0.77422575
58	Insulin secretion_Homo sapiens_hsa04911	0.76369370
59	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.70814429
60	Serotonergic synapse_Homo sapiens_hsa04726	0.70637861
61	Homologous recombination_Homo sapiens_hsa03440	0.69967552
62	Nitrogen metabolism_Homo sapiens_hsa00910	0.69668920
63	Metabolic pathways_Homo sapiens_hsa01100	0.69446809
64	Basal transcription factors_Homo sapiens_hsa03022	0.68581867
65	GABAergic synapse_Homo sapiens_hsa04727	0.67813564
66	Pyrimidine metabolism_Homo sapiens_hsa00240	0.67180569
67	Arginine and proline metabolism_Homo sapiens_hsa00330	0.66060999
68	Salivary secretion_Homo sapiens_hsa04970	0.65917460
69	Circadian entrainment_Homo sapiens_hsa04713	0.65731052
70	Pyruvate metabolism_Homo sapiens_hsa00620	0.63967499
71	Purine metabolism_Homo sapiens_hsa00230	0.63638296
72	Caffeine metabolism_Homo sapiens_hsa00232	0.61336420
73	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.60107940
74	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.56136157
75	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.54710814
76	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.54408437
77	Fatty acid degradation_Homo sapiens_hsa00071	0.53061791
78	Fatty acid metabolism_Homo sapiens_hsa01212	0.51108848
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.48884239
80	Tyrosine metabolism_Homo sapiens_hsa00350	0.48171434
81	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.47315000
82	Fat digestion and absorption_Homo sapiens_hsa04975	0.47170482
83	Rheumatoid arthritis_Homo sapiens_hsa05323	0.45957691
84	Ether lipid metabolism_Homo sapiens_hsa00565	0.45938396
85	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.45813831
86	Nucleotide excision repair_Homo sapiens_hsa03420	0.43819338
87	Sulfur relay system_Homo sapiens_hsa04122	0.43153408
88	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.43067619
89	beta-Alanine metabolism_Homo sapiens_hsa00410	0.41770331
90	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.38425384
91	Gastric acid secretion_Homo sapiens_hsa04971	0.37128755
92	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.37064844
93	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.34705723
94	Renin secretion_Homo sapiens_hsa04924	0.31852164
95	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.31202561
96	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.30965999
97	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.30870718
98	Glutamatergic synapse_Homo sapiens_hsa04724	0.30485115
99	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.27302941
100	Base excision repair_Homo sapiens_hsa03410	0.27198878

CALM1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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