CALM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.36311286
2synaptic vesicle exocytosis (GO:0016079)5.33887934
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.29044909
4neuron cell-cell adhesion (GO:0007158)5.21009498
5protein localization to synapse (GO:0035418)5.08032208
6regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.94664648
7ionotropic glutamate receptor signaling pathway (GO:0035235)4.81159274
8regulation of short-term neuronal synaptic plasticity (GO:0048172)4.76495764
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.76419117
10regulation of glutamate receptor signaling pathway (GO:1900449)4.73634585
11glutamate receptor signaling pathway (GO:0007215)4.63668731
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.59013845
13regulation of synaptic vesicle exocytosis (GO:2000300)4.57575554
14presynaptic membrane assembly (GO:0097105)4.56137837
15glutamate secretion (GO:0014047)4.56074716
16neuron-neuron synaptic transmission (GO:0007270)4.50380349
17DNA double-strand break processing (GO:0000729)4.47520928
18gamma-aminobutyric acid signaling pathway (GO:0007214)4.39030639
19response to histamine (GO:0034776)4.29113120
20presynaptic membrane organization (GO:0097090)4.27758281
21neurotransmitter-gated ion channel clustering (GO:0072578)4.26269535
22synaptic transmission, glutamatergic (GO:0035249)4.24796955
23neuronal action potential propagation (GO:0019227)4.23679766
24cullin deneddylation (GO:0010388)4.19150419
25long-term synaptic potentiation (GO:0060291)4.16799988
26regulation of synaptic vesicle transport (GO:1902803)4.11147912
27positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.10879797
28negative regulation of synaptic transmission, GABAergic (GO:0032229)4.10839368
29regulation of excitatory postsynaptic membrane potential (GO:0060079)4.04564225
30postsynaptic membrane organization (GO:0001941)4.04149297
31regulation of glutamate secretion (GO:0014048)4.02115763
32locomotory exploration behavior (GO:0035641)3.94787049
33behavioral response to cocaine (GO:0048148)3.94431257
34proteasome assembly (GO:0043248)3.93329201
35regulation of long-term neuronal synaptic plasticity (GO:0048169)3.88093164
36regulation of postsynaptic membrane potential (GO:0060078)3.86130101
37exploration behavior (GO:0035640)3.81311682
38ATP hydrolysis coupled proton transport (GO:0015991)3.80830141
39energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.80830141
40positive regulation of synapse maturation (GO:0090129)3.79227404
41positive regulation of neurotransmitter secretion (GO:0001956)3.76950826
42behavioral fear response (GO:0001662)3.76804399
43behavioral defense response (GO:0002209)3.76804399
44neuron recognition (GO:0008038)3.76644733
45protein deneddylation (GO:0000338)3.72962403
46neurotransmitter secretion (GO:0007269)3.70645330
47fear response (GO:0042596)3.65011015
48G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.60533600
49regulation of synaptic plasticity (GO:0048167)3.59749280
50synaptic vesicle endocytosis (GO:0048488)3.59043860
51transferrin transport (GO:0033572)3.57844446
52pyrimidine nucleobase catabolic process (GO:0006208)3.56153056
53regulation of neuronal synaptic plasticity (GO:0048168)3.55810262
54mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.53725683
55regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.46153180
56synaptic vesicle maturation (GO:0016188)3.45770237
57startle response (GO:0001964)3.45125934
58regulation of synaptic transmission, glutamatergic (GO:0051966)3.42908989
59positive regulation of neurotransmitter transport (GO:0051590)3.41060299
60negative regulation of dendrite morphogenesis (GO:0050774)3.40159294
61cerebellar granule cell differentiation (GO:0021707)3.38544143
62synaptic transmission, dopaminergic (GO:0001963)3.38460915
63female mating behavior (GO:0060180)3.36801354
64positive regulation of synapse assembly (GO:0051965)3.36663460
65positive regulation of membrane potential (GO:0045838)3.35448055
66long-term memory (GO:0007616)3.34732075
67regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.33009797
68membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.30294311
69trivalent inorganic cation transport (GO:0072512)3.30000452
70ferric iron transport (GO:0015682)3.30000452
71regulation of female receptivity (GO:0045924)3.29264280
72axonal fasciculation (GO:0007413)3.28499815
73G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.28102279
74histone H2A acetylation (GO:0043968)3.26511485
75long term synaptic depression (GO:0060292)3.26314595
76regulation of neurotransmitter secretion (GO:0046928)3.24223174
77regulation of protein kinase A signaling (GO:0010738)3.23962360
78ATP synthesis coupled proton transport (GO:0015986)3.22740566
79energy coupled proton transport, down electrochemical gradient (GO:0015985)3.22740566
80intraciliary transport (GO:0042073)3.22664595
81regulation of dendritic spine morphogenesis (GO:0061001)3.19770450
82regulation of vesicle fusion (GO:0031338)3.18317267
83cochlea development (GO:0090102)3.18295540
84serotonin metabolic process (GO:0042428)3.18150055
85transmission of nerve impulse (GO:0019226)3.14922523
86membrane depolarization (GO:0051899)3.14536691
87neurotransmitter transport (GO:0006836)3.13699433
88regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.12308133
89regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.12308133
90learning (GO:0007612)3.12007653
91protein localization to cilium (GO:0061512)3.12001893
92negative regulation of amino acid transport (GO:0051956)3.10708491
93negative regulation of dendrite development (GO:2000171)3.10043137
94detection of calcium ion (GO:0005513)3.09715455
95innervation (GO:0060384)3.08863317
96nucleobase catabolic process (GO:0046113)3.07851380
97regulation of synapse maturation (GO:0090128)3.07657125
98mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.06760405
99regulation of voltage-gated calcium channel activity (GO:1901385)3.04762005
100regulation of synapse structural plasticity (GO:0051823)3.03911682
101microtubule depolymerization (GO:0007019)3.03774500
102regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.03674267
103negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.03640023
104positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.03560366
105respiratory chain complex IV assembly (GO:0008535)3.02048673
106positive regulation of synaptic transmission (GO:0050806)3.01925691
107response to amphetamine (GO:0001975)3.01555167
108striatum development (GO:0021756)2.99637182
109regulation of neurotransmitter transport (GO:0051588)2.98793442
110synaptic transmission (GO:0007268)2.97867974
111glycosphingolipid biosynthetic process (GO:0006688)2.90958118
112negative regulation of DNA recombination (GO:0045910)2.89639592
113platelet dense granule organization (GO:0060155)2.84195549
114CENP-A containing nucleosome assembly (GO:0034080)2.83430011
115DNA ligation (GO:0006266)2.82731880
116protein neddylation (GO:0045116)2.81791386
117DNA damage response, detection of DNA damage (GO:0042769)2.81738122
118positive regulation of mitochondrial fission (GO:0090141)2.81065749
119protein complex biogenesis (GO:0070271)2.80074789
120chromatin remodeling at centromere (GO:0031055)2.77433925
121organelle disassembly (GO:1903008)2.76038599
122centriole replication (GO:0007099)2.73937244
123protein K11-linked ubiquitination (GO:0070979)2.72581587
124microtubule polymerization or depolymerization (GO:0031109)2.69691099
125regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.68744350
126regulation of mitotic spindle checkpoint (GO:1903504)2.68744350
127peptidyl-cysteine modification (GO:0018198)2.68389649
128ribonucleoprotein complex disassembly (GO:0032988)2.64342656
129protein-cofactor linkage (GO:0018065)2.62444715
130anterograde synaptic vesicle transport (GO:0048490)2.60463578
131mitochondrial respiratory chain complex assembly (GO:0033108)2.59489128
132regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.58956038
133cilium morphogenesis (GO:0060271)2.57334840
134histone exchange (GO:0043486)2.55355520
135epithelial cilium movement (GO:0003351)2.55190774
136C4-dicarboxylate transport (GO:0015740)2.55047651
137regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.55016165
138cytochrome complex assembly (GO:0017004)2.53313390
139positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.52657365
140retinal cone cell development (GO:0046549)2.52455973
141resolution of meiotic recombination intermediates (GO:0000712)2.50328815
142mitochondrial respiratory chain complex I assembly (GO:0032981)2.46954971
143NADH dehydrogenase complex assembly (GO:0010257)2.46954971
144mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.46954971
145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.46868911
146gamma-aminobutyric acid transport (GO:0015812)2.46248893
147cilium assembly (GO:0042384)2.45089211
148cilium organization (GO:0044782)2.44748721
149negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.43164048
150sequestering of actin monomers (GO:0042989)2.39814571
151regulation of cilium movement (GO:0003352)2.39807949
152nonmotile primary cilium assembly (GO:0035058)2.38255444
153regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.35993959
154L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.35952164
155kinetochore assembly (GO:0051382)2.34354493
156kinetochore organization (GO:0051383)2.33593636
157anterograde axon cargo transport (GO:0008089)2.33122645
158nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.33009071
159postreplication repair (GO:0006301)2.30730958
160DNA catabolic process, exonucleolytic (GO:0000738)2.30623178
161establishment of protein localization to mitochondrial membrane (GO:0090151)2.30413808
162exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.29118842
163establishment of melanosome localization (GO:0032401)2.28378250
164signal peptide processing (GO:0006465)2.28058004
165melanosome transport (GO:0032402)2.26448481
166regulation of cellular amino acid metabolic process (GO:0006521)2.26356308
167respiratory electron transport chain (GO:0022904)2.26288469
168response to pheromone (GO:0019236)2.25749365
169negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.25445595
170limb bud formation (GO:0060174)2.25376233
171retinal ganglion cell axon guidance (GO:0031290)2.24958202
172positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.24126953
173electron transport chain (GO:0022900)2.23848253

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.17345188
2GBX2_23144817_ChIP-Seq_PC3_Human4.72829877
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15626464
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.01258085
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99773236
6TAF15_26573619_Chip-Seq_HEK293_Human2.95493152
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.95072028
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.71218307
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.66776939
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.61701789
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45858405
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45858405
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45831960
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45203423
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44688133
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.43239072
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.43069945
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.39176742
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.38157511
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33239173
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.31061369
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.29478396
23* RARB_27405468_Chip-Seq_BRAIN_Mouse2.27844740
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23882841
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.22341486
26* REST_18959480_ChIP-ChIP_MESCs_Mouse2.10447863
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09747254
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06688468
29P300_19829295_ChIP-Seq_ESCs_Human2.05962191
30EST1_17652178_ChIP-ChIP_JURKAT_Human2.05542549
31ELK1_19687146_ChIP-ChIP_HELA_Human2.02552143
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02187635
33FUS_26573619_Chip-Seq_HEK293_Human2.01840899
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.98320128
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97944464
36* SMAD4_21799915_ChIP-Seq_A2780_Human1.97725677
37VDR_22108803_ChIP-Seq_LS180_Human1.95359870
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.91372061
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90979321
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.90456225
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84761266
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84645123
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.83958568
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81923646
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77687409
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74430158
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74064819
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68894117
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.66782442
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.65263741
51DROSHA_22980978_ChIP-Seq_HELA_Human1.62458868
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61520253
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.59842409
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59578652
55ZNF274_21170338_ChIP-Seq_K562_Hela1.58696450
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58496343
57AR_21572438_ChIP-Seq_LNCaP_Human1.55864939
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.55000718
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50979541
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47914515
61AR_25329375_ChIP-Seq_VCAP_Human1.47827177
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45339827
63RNF2_27304074_Chip-Seq_NSC_Mouse1.44182810
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43419789
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42490921
66* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.41887386
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41223473
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.40617069
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38889596
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.37177908
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36345497
72IGF1R_20145208_ChIP-Seq_DFB_Human1.36030171
73* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35203013
74RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34837170
75JUN_21703547_ChIP-Seq_K562_Human1.34335496
76* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.33970738
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.31914930
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.31517215
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30013563
80* VDR_23849224_ChIP-Seq_CD4+_Human1.29424415
81SOX2_21211035_ChIP-Seq_LN229_Gbm1.29282095
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28582947
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.25923701
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25802766
85RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25725165
86* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.25567641
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25369889
88ER_23166858_ChIP-Seq_MCF-7_Human1.25166281
89CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21171846
90STAT3_23295773_ChIP-Seq_U87_Human1.20614839
91MYC_18940864_ChIP-ChIP_HL60_Human1.20494090
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20349434
93SMAD_19615063_ChIP-ChIP_OVARY_Human1.19358292
94EWS_26573619_Chip-Seq_HEK293_Human1.18402355
95* TCF4_23295773_ChIP-Seq_U87_Human1.18145962
96RUNX2_22187159_ChIP-Seq_PCA_Human1.17612729
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16271131
98* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.16255457
99NANOG_19829295_ChIP-Seq_ESCs_Human1.14933679
100SOX2_19829295_ChIP-Seq_ESCs_Human1.14933679
101NANOG_18555785_Chip-Seq_ESCs_Mouse1.14539268
102CMYC_18555785_Chip-Seq_ESCs_Mouse1.13753262
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13263285
104TP53_22573176_ChIP-Seq_HFKS_Human1.12482359
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11870012
106* TCF4_22108803_ChIP-Seq_LS180_Human1.11617086
107* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11073017
108CRX_20693478_ChIP-Seq_RETINA_Mouse1.09761029
109SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09508157
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08708193
111ERG_21242973_ChIP-ChIP_JURKAT_Human1.08608705
112P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08606198
113P300_18555785_Chip-Seq_ESCs_Mouse1.08526283
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06905141
115* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06427729
116STAT3_18555785_Chip-Seq_ESCs_Mouse1.06366327
117TP53_18474530_ChIP-ChIP_U2OS_Human1.06294270
118SOX9_26525672_Chip-Seq_HEART_Mouse1.05960646
119MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05441825
120TAL1_26923725_Chip-Seq_HPCs_Mouse1.04758022
121JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.03751157
122SOX2_18555785_Chip-Seq_ESCs_Mouse1.02181203
123FLI1_21867929_ChIP-Seq_TH2_Mouse1.02090057
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01850339
125* BCAT_22108803_ChIP-Seq_LS180_Human1.01355895
126ETS1_20019798_ChIP-Seq_JURKAT_Human1.01271368
127EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00225375
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99452808
129EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99424750
130BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99134741
131E2F1_18555785_Chip-Seq_ESCs_Mouse0.98675418
132* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98304470
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98172359
134TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98172359
135KDM2B_26808549_Chip-Seq_REH_Human0.97568345
136RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97429742
137HTT_18923047_ChIP-ChIP_STHdh_Human0.97290684
138* ARNT_22903824_ChIP-Seq_MCF-7_Human0.96878149
139P53_22387025_ChIP-Seq_ESCs_Mouse0.96559391
140FLI1_27457419_Chip-Seq_LIVER_Mouse0.96171545
141RING1B_27294783_Chip-Seq_ESCs_Mouse0.95594475
142AR_19668381_ChIP-Seq_PC3_Human0.95384119
143TP53_16413492_ChIP-PET_HCT116_Human0.95298700
144CBP_20019798_ChIP-Seq_JUKART_Human0.95248278
145IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95248278
146MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92552576

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern6.47330405
2MP0004859_abnormal_synaptic_plasticity5.53381132
3MP0003635_abnormal_synaptic_transmissio4.01673745
4MP0001968_abnormal_touch/_nociception3.58207828
5MP0009745_abnormal_behavioral_response3.52523986
6MP0004270_analgesia3.47373000
7MP0002063_abnormal_learning/memory/cond3.39168546
8MP0002736_abnormal_nociception_after3.28550471
9MP0002064_seizures3.12684346
10MP0002572_abnormal_emotion/affect_behav2.99004754
11MP0009046_muscle_twitch2.92663315
12MP0002102_abnormal_ear_morphology2.73583285
13MP0002272_abnormal_nervous_system2.65494771
14MP0002735_abnormal_chemical_nociception2.53968439
15MP0001501_abnormal_sleep_pattern2.51773187
16MP0001440_abnormal_grooming_behavior2.50880332
17MP0002822_catalepsy2.46855038
18MP0002734_abnormal_mechanical_nocicepti2.45009709
19MP0001529_abnormal_vocalization2.30805453
20MP0006276_abnormal_autonomic_nervous2.25842867
21MP0001486_abnormal_startle_reflex2.22893335
22MP0002067_abnormal_sensory_capabilities2.16225760
23MP0002837_dystrophic_cardiac_calcinosis1.98621951
24MP0001984_abnormal_olfaction1.94857004
25MP0002733_abnormal_thermal_nociception1.93378537
26MP0001970_abnormal_pain_threshold1.91322462
27MP0002184_abnormal_innervation1.88841720
28MP0008058_abnormal_DNA_repair1.88635804
29MP0003787_abnormal_imprinting1.88185310
30MP0006072_abnormal_retinal_apoptosis1.85678675
31MP0001188_hyperpigmentation1.84061543
32MP0004924_abnormal_behavior1.82183931
33MP0005386_behavior/neurological_phenoty1.82183931
34MP0005423_abnormal_somatic_nervous1.78302250
35MP0000778_abnormal_nervous_system1.74226022
36MP0001905_abnormal_dopamine_level1.73533282
37MP0003879_abnormal_hair_cell1.69951363
38MP0002557_abnormal_social/conspecific_i1.67457459
39MP0003329_amyloid_beta_deposits1.60673738
40MP0005646_abnormal_pituitary_gland1.59463929
41MP0009780_abnormal_chondrocyte_physiolo1.58953324
42MP0008789_abnormal_olfactory_epithelium1.57390068
43MP0003122_maternal_imprinting1.56297500
44MP0004811_abnormal_neuron_physiology1.50046185
45MP0004147_increased_porphyrin_level1.49733209
46MP0005253_abnormal_eye_physiology1.45935670
47MP0002876_abnormal_thyroid_physiology1.43146598
48MP0008569_lethality_at_weaning1.40365893
49MP0002638_abnormal_pupillary_reflex1.37689307
50MP0002066_abnormal_motor_capabilities/c1.32469624
51MP0002909_abnormal_adrenal_gland1.32212244
52MP0000569_abnormal_digit_pigmentation1.30208938
53MP0000955_abnormal_spinal_cord1.29216671
54MP0003718_maternal_effect1.29177190
55MP0002090_abnormal_vision1.27310374
56MP0002882_abnormal_neuron_morphology1.26018957
57MP0000372_irregular_coat_pigmentation1.25562420
58MP0005084_abnormal_gallbladder_morpholo1.25124355
59MP0004142_abnormal_muscle_tone1.23944941
60MP0004133_heterotaxia1.23431660
61MP0010094_abnormal_chromosome_stability1.22985035
62MP0010386_abnormal_urinary_bladder1.22831379
63MP0005367_renal/urinary_system_phenotyp1.18210112
64MP0000516_abnormal_urinary_system1.18210112
65MP0009697_abnormal_copulation1.15068358
66MP0003890_abnormal_embryonic-extraembry1.13269522
67MP0001502_abnormal_circadian_rhythm1.13186870
68MP0001177_atelectasis1.12277092
69MP0005645_abnormal_hypothalamus_physiol1.11514720
70MP0000647_abnormal_sebaceous_gland1.09905058
71MP0002234_abnormal_pharynx_morphology1.08074800
72MP0004145_abnormal_muscle_electrophysio1.07684310
73MP0002938_white_spotting1.06579791
74MP0003633_abnormal_nervous_system1.04878320
75MP0000013_abnormal_adipose_tissue1.04485438
76MP0000751_myopathy1.03490874
77MP0003195_calcinosis1.03466167
78MP0002233_abnormal_nose_morphology1.02986943
79MP0008995_early_reproductive_senescence1.02158295
80MP0008877_abnormal_DNA_methylation0.99821185
81MP0008872_abnormal_physiological_respon0.99348370
82MP0004484_altered_response_of0.98930335
83MP0002152_abnormal_brain_morphology0.98389223
84MP0004858_abnormal_nervous_system0.98182910
85MP0003137_abnormal_impulse_conducting0.97461489
86MP0003631_nervous_system_phenotype0.93841729
87MP0008057_abnormal_DNA_replication0.92779346
88MP0001963_abnormal_hearing_physiology0.92763205
89MP0005171_absent_coat_pigmentation0.92490344
90MP0001293_anophthalmia0.92468072
91MP0000427_abnormal_hair_cycle0.90861849
92MP0006036_abnormal_mitochondrial_physio0.88811842
93MP0004742_abnormal_vestibular_system0.87734007
94MP0005248_abnormal_Harderian_gland0.87368490
95MP0003786_premature_aging0.86999298
96MP0002069_abnormal_eating/drinking_beha0.86489680
97MP0001664_abnormal_digestion0.86296469
98MP0001299_abnormal_eye_distance/0.86230352
99MP0008874_decreased_physiological_sensi0.86111852
100MP0003937_abnormal_limbs/digits/tail_de0.85950845
101MP0008875_abnormal_xenobiotic_pharmacok0.84351303
102MP0002229_neurodegeneration0.84329820
103MP0003119_abnormal_digestive_system0.83663766
104MP0005394_taste/olfaction_phenotype0.83218895
105MP0005499_abnormal_olfactory_system0.83218895
106MP0005551_abnormal_eye_electrophysiolog0.82391786
107MP0005409_darkened_coat_color0.80353652
108MP0005535_abnormal_body_temperature0.79789480
109MP0004215_abnormal_myocardial_fiber0.79385922
110MP0004085_abnormal_heartbeat0.79157194
111MP0000639_abnormal_adrenal_gland0.78635855
112MP0000631_abnormal_neuroendocrine_gland0.78554180
113MP0008932_abnormal_embryonic_tissue0.75817073
114MP0002752_abnormal_somatic_nervous0.72944148
115MP0003121_genomic_imprinting0.68743936
116MP0009379_abnormal_foot_pigmentation0.67250032
117MP0004885_abnormal_endolymph0.64872429
118MP0002163_abnormal_gland_morphology0.64670016
119MP0000604_amyloidosis0.64193205
120MP0003123_paternal_imprinting0.63796204
121MP0006292_abnormal_olfactory_placode0.63573026
122MP0001485_abnormal_pinna_reflex0.63484688
123MP0005187_abnormal_penis_morphology0.63462851
124MP0000026_abnormal_inner_ear0.61739336
125MP0005379_endocrine/exocrine_gland_phen0.60436139
126MP0006035_abnormal_mitochondrial_morpho0.59143526
127MP0003632_abnormal_nervous_system0.58010768
128MP0001943_abnormal_respiration0.56647096
129MP0003183_abnormal_peptide_metabolism0.53545995
130MP0001765_abnormal_ion_homeostasis0.50875070
131MP0004036_abnormal_muscle_relaxation0.47760380
132MP0008004_abnormal_stomach_pH0.47600439
133MP0003956_abnormal_body_size0.47560329
134MP0005410_abnormal_fertilization0.47362746
135MP0003634_abnormal_glial_cell0.46797465
136MP0003861_abnormal_nervous_system0.44895450
137MP0004233_abnormal_muscle_weight0.44895368
138MP0002751_abnormal_autonomic_nervous0.44767361

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.34814708
2Atonic seizures (HP:0010819)5.52958984
3Focal seizures (HP:0007359)5.49719565
4Epileptic encephalopathy (HP:0200134)5.43336618
5Hyperventilation (HP:0002883)5.40705505
6Myokymia (HP:0002411)5.25675149
7Visual hallucinations (HP:0002367)4.92047237
8Absence seizures (HP:0002121)4.63776466
9Febrile seizures (HP:0002373)4.56470096
10Dialeptic seizures (HP:0011146)4.34460588
11Broad-based gait (HP:0002136)3.83423320
12Amblyopia (HP:0000646)3.77236756
13Acute necrotizing encephalopathy (HP:0006965)3.77075097
14Generalized tonic-clonic seizures (HP:0002069)3.61171053
15Progressive cerebellar ataxia (HP:0002073)3.61046716
16Abnormal mitochondria in muscle tissue (HP:0008316)3.50084127
17Progressive macrocephaly (HP:0004481)3.37623593
18Mitochondrial inheritance (HP:0001427)3.10818843
19Gaze-evoked nystagmus (HP:0000640)3.08819655
20Abnormality of the labia minora (HP:0012880)3.06010998
21Truncal ataxia (HP:0002078)2.97271424
22Anxiety (HP:0000739)2.92406461
23Molar tooth sign on MRI (HP:0002419)2.89160969
24Abnormality of midbrain morphology (HP:0002418)2.89160969
25Drooling (HP:0002307)2.88656574
26Excessive salivation (HP:0003781)2.88656574
27Gait imbalance (HP:0002141)2.86553191
28Epileptiform EEG discharges (HP:0011182)2.84193950
29Hypothermia (HP:0002045)2.80721363
30Delusions (HP:0000746)2.79977753
31Acute encephalopathy (HP:0006846)2.79387379
32Poor eye contact (HP:0000817)2.79335823
33True hermaphroditism (HP:0010459)2.78818294
34Methylmalonic acidemia (HP:0002912)2.75323545
35Intestinal atresia (HP:0011100)2.74744048
36Pancreatic cysts (HP:0001737)2.73063109
37Medial flaring of the eyebrow (HP:0010747)2.72881622
38Impaired vibration sensation in the lower limbs (HP:0002166)2.70499401
39Pancreatic fibrosis (HP:0100732)2.65733583
40Congenital primary aphakia (HP:0007707)2.65526777
41Cerebral inclusion bodies (HP:0100314)2.64258724
42Protruding tongue (HP:0010808)2.62546368
43Increased CSF lactate (HP:0002490)2.59665222
44Inability to walk (HP:0002540)2.58726929
45Volvulus (HP:0002580)2.57555446
46Abnormal hair whorl (HP:0010721)2.56058845
47Pheochromocytoma (HP:0002666)2.55223353
48Nephronophthisis (HP:0000090)2.49929601
49Nephrogenic diabetes insipidus (HP:0009806)2.46843605
50Neuroendocrine neoplasm (HP:0100634)2.45004138
51Dysmetria (HP:0001310)2.43586843
52EEG with generalized epileptiform discharges (HP:0011198)2.43531767
53Dysdiadochokinesis (HP:0002075)2.42768794
54Impaired smooth pursuit (HP:0007772)2.42558876
55Depression (HP:0000716)2.41902305
56Abnormal eating behavior (HP:0100738)2.41709403
57Degeneration of anterior horn cells (HP:0002398)2.41537054
58Abnormality of the anterior horn cell (HP:0006802)2.41537054
59Progressive inability to walk (HP:0002505)2.41456011
60Abnormality of binocular vision (HP:0011514)2.39495315
61Diplopia (HP:0000651)2.39495315
62Hepatic necrosis (HP:0002605)2.39158254
63Impaired social interactions (HP:0000735)2.34640400
64Abnormal social behavior (HP:0012433)2.34640400
65Action tremor (HP:0002345)2.33824876
66Atrophy/Degeneration involving motor neurons (HP:0007373)2.33486019
67Hepatocellular necrosis (HP:0001404)2.31724736
68Supranuclear gaze palsy (HP:0000605)2.29950741
69Termporal pattern (HP:0011008)2.29775665
70Insidious onset (HP:0003587)2.29775665
71Absent speech (HP:0001344)2.29130260
72Decreased activity of mitochondrial respiratory chain (HP:0008972)2.25663493
73Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.25663493
74Hydroureter (HP:0000072)2.21900937
75Hypsarrhythmia (HP:0002521)2.20182364
76Optic disc pallor (HP:0000543)2.20060661
77Abnormality of the lower motor neuron (HP:0002366)2.18924953
783-Methylglutaconic aciduria (HP:0003535)2.14471014
79Polyphagia (HP:0002591)2.12863039
80Dysmetric saccades (HP:0000641)2.08910343
81Cerebral edema (HP:0002181)2.06931750
82Renal cortical cysts (HP:0000803)2.06605053
83Methylmalonic aciduria (HP:0012120)2.06270316
84Bradykinesia (HP:0002067)2.05676786
85Postaxial hand polydactyly (HP:0001162)2.05539708
86Short tibia (HP:0005736)2.04547271
87Aplasia/Hypoplasia of the tibia (HP:0005772)2.03728914
88Lissencephaly (HP:0001339)2.03139138
89Limb dystonia (HP:0002451)2.02761779
90Urinary bladder sphincter dysfunction (HP:0002839)2.02750857
91Ependymoma (HP:0002888)2.02437574
92Hemiparesis (HP:0001269)2.02396036
93Scanning speech (HP:0002168)2.01635803
94Poor suck (HP:0002033)2.01472101
95Abnormality of salivation (HP:0100755)2.01143763
96Genital tract atresia (HP:0001827)2.00531050
97Fetal akinesia sequence (HP:0001989)2.00525887
98Stereotypic behavior (HP:0000733)2.00087577
99Optic nerve hypoplasia (HP:0000609)1.97976166
100Psychosis (HP:0000709)1.97888167
101Split foot (HP:0001839)1.97786143
102Vaginal atresia (HP:0000148)1.97360349
103Dynein arm defect of respiratory motile cilia (HP:0012255)1.96901361
104Absent/shortened dynein arms (HP:0200106)1.96901361
105Abnormality of ocular smooth pursuit (HP:0000617)1.96340398
106Increased serum pyruvate (HP:0003542)1.95457827
107Abnormality of glycolysis (HP:0004366)1.95457827
108Astrocytoma (HP:0009592)1.94731542
109Abnormality of the astrocytes (HP:0100707)1.94731542
110Blue irides (HP:0000635)1.93677132
111Specific learning disability (HP:0001328)1.93410332
112Lipid accumulation in hepatocytes (HP:0006561)1.92385570
113Increased hepatocellular lipid droplets (HP:0006565)1.91380000
114Abnormality of the renal medulla (HP:0100957)1.90716113
115Aplasia/Hypoplasia of the tongue (HP:0010295)1.89238645
116Poor coordination (HP:0002370)1.89138574
117Heterochromia iridis (HP:0001100)1.88783562
118Incomplete penetrance (HP:0003829)1.88711779
119Esotropia (HP:0000565)1.88628414
120X-linked dominant inheritance (HP:0001423)1.87693396
121Hyperthyroidism (HP:0000836)1.86838363
122Shoulder girdle muscle weakness (HP:0003547)1.86459053
123Unsteady gait (HP:0002317)1.86378802
124Impaired vibratory sensation (HP:0002495)1.86112165
125Abnormal ciliary motility (HP:0012262)1.85817896
126Dysautonomia (HP:0002459)1.85183604
127Muscular hypotonia of the trunk (HP:0008936)1.83727496
128Cerebral hypomyelination (HP:0006808)1.83725001
129Abnormal lung lobation (HP:0002101)1.81896546
130Generalized myoclonic seizures (HP:0002123)1.81824170
131Bifid tongue (HP:0010297)1.81745952
132Glioma (HP:0009733)1.81707337
133Focal dystonia (HP:0004373)1.81597096
134Median cleft lip (HP:0000161)1.81065065
135Delayed gross motor development (HP:0002194)1.80804572
136Retinal dysplasia (HP:0007973)1.79522187
137Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78430438
138Neurofibrillary tangles (HP:0002185)1.77603260
139Leukodystrophy (HP:0002415)1.77438229
140Sensory axonal neuropathy (HP:0003390)1.76820175
141Amyotrophic lateral sclerosis (HP:0007354)1.76621527
142Gait ataxia (HP:0002066)1.76326178
143Abolished electroretinogram (ERG) (HP:0000550)1.76257374
144Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.75704920
145Degeneration of the lateral corticospinal tracts (HP:0002314)1.75704920
146Septo-optic dysplasia (HP:0100842)1.75251422
147Narrow forehead (HP:0000341)1.72529395
148Oligodactyly (hands) (HP:0001180)1.71832803
149Postaxial foot polydactyly (HP:0001830)1.70115219
150Aplasia/Hypoplasia of the uvula (HP:0010293)1.69824589
151Broad foot (HP:0001769)1.69790717
152Hyperglycinemia (HP:0002154)1.69382775
153Meckel diverticulum (HP:0002245)1.69078381
154Abnormality of the ileum (HP:0001549)1.68940516
155Lactic acidosis (HP:0003128)1.68091685
156Abnormality of chromosome stability (HP:0003220)1.67685119
157Decreased testicular size (HP:0008734)1.67536495

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.56096252
2CASK4.48014128
3NTRK34.14824374
4MAP3K124.04135979
5TRIM283.77811199
6RIPK43.53718299
7MAP3K43.14783985
8MAP2K73.09850450
9MAP4K22.63903216
10PLK22.57415064
11MAP3K92.46366318
12DAPK12.39577640
13ERBB32.38008032
14MINK12.35242466
15CDK192.24033549
16DAPK22.19790921
17PNCK2.05160156
18MAP2K42.04957850
19NEK11.98571336
20FRK1.91891466
21GRK51.90028192
22ARAF1.86603932
23BUB11.85720171
24BMPR21.83508982
25MST41.83201117
26NME11.81891703
27WEE11.79129792
28SRPK11.72863503
29KSR11.67767077
30EIF2AK31.62900760
31MARK11.61224097
32PINK11.60599413
33SIK31.60171619
34CCNB11.58251207
35PTK2B1.55871053
36CSNK1G31.52502241
37BMPR1B1.47868070
38EIF2AK11.46388538
39MKNK21.45998627
40CSNK1G11.42429979
41KSR21.38829155
42CAMKK21.33810408
43CSNK1A1L1.31000798
44AKT31.28625234
45PRKCG1.24479836
46LIMK11.24363459
47PLK41.22975599
48CAMK2A1.20587883
49CDK51.19318178
50OXSR11.18715500
51PBK1.16343798
52MAPK131.14721754
53CAMK2B1.14030071
54TTK1.12148330
55NUAK11.09427716
56TNIK1.08643761
57BRSK21.06807394
58FGR1.06377708
59MKNK11.05538218
60DYRK21.04366113
61NTRK21.02863982
62ZAK1.00388743
63BCR0.98219604
64TSSK60.97975590
65PAK60.97066718
66PRPF4B0.96226347
67RAF10.93314575
68SIK20.93151108
69NTRK10.91972233
70FES0.91640105
71CAMKK10.90745331
72PLK10.89825270
73GRK60.89308258
74GRK10.87952164
75BRAF0.85443914
76CDK180.84387114
77STK160.83525643
78MAP3K130.81337998
79MYLK0.79918430
80CDK140.78298665
81TESK10.77992679
82STK38L0.77143544
83GRK70.75142981
84ACVR1B0.75089548
85CDK150.73956577
86VRK10.72679869
87BRSK10.70709413
88ERBB40.68784619
89SGK20.67630205
90SGK2230.67423541
91SGK4940.67423541
92BCKDK0.66270283
93PDK30.66246896
94PDK40.66246896
95MAP3K20.65531320
96DYRK1A0.64278307
97FER0.63696536
98CDK11A0.63586388
99PRKCE0.62625619
100PKN10.60371227
101INSRR0.60230167
102STK390.59663363
103DYRK30.58099561
104ADRBK20.57524997
105ADRBK10.56764772
106UHMK10.56478992
107CAMK2D0.56439363
108CDC70.55648238
109DAPK30.54343161
110MUSK0.52533838
111MAP3K60.52212588
112EIF2AK20.51474360
113SGK10.51134747
114RPS6KA40.50714910
115TNK20.50460060
116PHKG20.48352378
117PHKG10.48352378
118CAMK10.46262653
119MAP2K10.45532913
120CAMK2G0.44302313
121PLK30.42189737
122WNK30.40939722
123CSNK1G20.39980316
124CSNK1A10.39660991
125ROCK20.39278363
126ATR0.38299844
127STK380.37445265
128STK110.37337370
129ATM0.35361311
130PRKG10.34851607
131PRKACA0.34389757
132LATS20.33558570
133CDK30.32192006
134CSNK1D0.32164703
135MAPK120.31826890
136STK30.31553327
137CSNK1E0.31375828
138PDK20.30868893
139CDK80.29158306
140PAK30.28847372
141PDK10.27465853
142RET0.27026014
143MAP3K10.26215162
144PDPK10.25870828
145PRKCA0.25381527
146PRKCB0.25194020
147SGK30.24765347
148RPS6KA30.23818679
149FYN0.23563145
150MOS0.23085266
151SYK0.23038955
152PRKCZ0.22739560

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.39827324
2Protein export_Homo sapiens_hsa030604.33342424
3Synaptic vesicle cycle_Homo sapiens_hsa047213.52471001
4Collecting duct acid secretion_Homo sapiens_hsa049663.14612874
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.96449413
6* Long-term potentiation_Homo sapiens_hsa047202.95616800
7Oxidative phosphorylation_Homo sapiens_hsa001902.87238355
8* Amphetamine addiction_Homo sapiens_hsa050312.72113772
9* Circadian entrainment_Homo sapiens_hsa047132.56151262
10Morphine addiction_Homo sapiens_hsa050322.54112298
11Glutamatergic synapse_Homo sapiens_hsa047242.49567556
12GABAergic synapse_Homo sapiens_hsa047272.46282257
13* Olfactory transduction_Homo sapiens_hsa047402.36509037
14Taste transduction_Homo sapiens_hsa047422.20471535
15* Dopaminergic synapse_Homo sapiens_hsa047282.20291704
16Parkinsons disease_Homo sapiens_hsa050122.18308211
17Non-homologous end-joining_Homo sapiens_hsa034502.14417106
18Alzheimers disease_Homo sapiens_hsa050102.09712733
19* Salivary secretion_Homo sapiens_hsa049702.01441992
20Propanoate metabolism_Homo sapiens_hsa006401.96673488
21Serotonergic synapse_Homo sapiens_hsa047261.93800370
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.93736673
23Long-term depression_Homo sapiens_hsa047301.90649782
24Vibrio cholerae infection_Homo sapiens_hsa051101.89828529
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.82540713
26* Renin secretion_Homo sapiens_hsa049241.81519737
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78183698
28Basal transcription factors_Homo sapiens_hsa030221.73740839
29Insulin secretion_Homo sapiens_hsa049111.69399864
30* Calcium signaling pathway_Homo sapiens_hsa040201.67955419
31Huntingtons disease_Homo sapiens_hsa050161.60872610
32Fanconi anemia pathway_Homo sapiens_hsa034601.60172986
33Cardiac muscle contraction_Homo sapiens_hsa042601.59021482
34Cholinergic synapse_Homo sapiens_hsa047251.58016628
35Steroid biosynthesis_Homo sapiens_hsa001001.55722408
36Butanoate metabolism_Homo sapiens_hsa006501.54371724
37* Oxytocin signaling pathway_Homo sapiens_hsa049211.53379438
38* Gastric acid secretion_Homo sapiens_hsa049711.52291379
39Fatty acid elongation_Homo sapiens_hsa000621.49382245
40Mismatch repair_Homo sapiens_hsa034301.48975507
41Cocaine addiction_Homo sapiens_hsa050301.48379098
42RNA polymerase_Homo sapiens_hsa030201.42833745
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41469593
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40919776
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38498697
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38113841
47* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.37267355
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.34277214
49Homologous recombination_Homo sapiens_hsa034401.29922994
50Gap junction_Homo sapiens_hsa045401.28703882
51RNA degradation_Homo sapiens_hsa030181.23478680
52* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22249503
53Vitamin B6 metabolism_Homo sapiens_hsa007501.19816237
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.14949540
55* GnRH signaling pathway_Homo sapiens_hsa049121.12896053
56* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11298064
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09395528
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.09059419
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05027626
60* cAMP signaling pathway_Homo sapiens_hsa040241.03671305
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01476838
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98866262
63Folate biosynthesis_Homo sapiens_hsa007900.95422770
64Axon guidance_Homo sapiens_hsa043600.95004116
65Peroxisome_Homo sapiens_hsa041460.93951325
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.93115841
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93098907
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.91801183
69* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89994213
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89951365
71* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89798963
72Nucleotide excision repair_Homo sapiens_hsa034200.89720105
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89659216
74* Oocyte meiosis_Homo sapiens_hsa041140.89659099
75RNA transport_Homo sapiens_hsa030130.89185983
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88404377
77Sulfur metabolism_Homo sapiens_hsa009200.87782217
78Rheumatoid arthritis_Homo sapiens_hsa053230.86543965
79beta-Alanine metabolism_Homo sapiens_hsa004100.84519010
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84215968
81Nitrogen metabolism_Homo sapiens_hsa009100.81893505
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80909422
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80392160
84Base excision repair_Homo sapiens_hsa034100.79393918
85* Melanogenesis_Homo sapiens_hsa049160.79270955
86* Estrogen signaling pathway_Homo sapiens_hsa049150.78691103
87* Vascular smooth muscle contraction_Homo sapiens_hsa042700.78147277
88* Phototransduction_Homo sapiens_hsa047440.77331778
89Cell cycle_Homo sapiens_hsa041100.74322230
90Purine metabolism_Homo sapiens_hsa002300.73172529
91ErbB signaling pathway_Homo sapiens_hsa040120.73146302
92Pancreatic secretion_Homo sapiens_hsa049720.71087212
93Selenocompound metabolism_Homo sapiens_hsa004500.70864979
94African trypanosomiasis_Homo sapiens_hsa051430.69282433
95Glutathione metabolism_Homo sapiens_hsa004800.66707038
96* Glioma_Homo sapiens_hsa052140.63816814
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.63473812
98Metabolic pathways_Homo sapiens_hsa011000.62636446
99Tryptophan metabolism_Homo sapiens_hsa003800.60987551
100Spliceosome_Homo sapiens_hsa030400.60524391
101Pyrimidine metabolism_Homo sapiens_hsa002400.60119502
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.59481546
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58864391
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57795061
105Phagosome_Homo sapiens_hsa041450.57335616
106Thyroid hormone synthesis_Homo sapiens_hsa049180.56830053
107Type II diabetes mellitus_Homo sapiens_hsa049300.56282079
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55834717
109Ether lipid metabolism_Homo sapiens_hsa005650.54978946
110Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54915711
111MAPK signaling pathway_Homo sapiens_hsa040100.54758481
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54418396
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53787771
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53766436
115VEGF signaling pathway_Homo sapiens_hsa043700.52630928
116Fatty acid metabolism_Homo sapiens_hsa012120.49294774
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49224060
118* Alcoholism_Homo sapiens_hsa050340.48910652
119Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47992996
120* Glucagon signaling pathway_Homo sapiens_hsa049220.47049379
121DNA replication_Homo sapiens_hsa030300.46476535
122Choline metabolism in cancer_Homo sapiens_hsa052310.46175878
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45704465
124Caffeine metabolism_Homo sapiens_hsa002320.45220302
125Proteasome_Homo sapiens_hsa030500.45090624
126Chemical carcinogenesis_Homo sapiens_hsa052040.44913311
127mRNA surveillance pathway_Homo sapiens_hsa030150.42132718
128Dilated cardiomyopathy_Homo sapiens_hsa054140.41706030
129Carbon metabolism_Homo sapiens_hsa012000.40589809
130* Ras signaling pathway_Homo sapiens_hsa040140.40481427
131Hippo signaling pathway_Homo sapiens_hsa043900.39380759
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38483345
133Pyruvate metabolism_Homo sapiens_hsa006200.37850722
134Type I diabetes mellitus_Homo sapiens_hsa049400.37378140
135Dorso-ventral axis formation_Homo sapiens_hsa043200.36629997
136Inositol phosphate metabolism_Homo sapiens_hsa005620.34899285
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.34631582
138Wnt signaling pathway_Homo sapiens_hsa043100.33776123
139Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32461887
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32060612
141Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31551081
142* Rap1 signaling pathway_Homo sapiens_hsa040150.30873046
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30546347
144Circadian rhythm_Homo sapiens_hsa047100.29398150
145Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26685149
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.26261329
147Prion diseases_Homo sapiens_hsa050200.22901757
148Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.20567413
149Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.19106505
150Regulation of autophagy_Homo sapiens_hsa041400.18754030
151* Neurotrophin signaling pathway_Homo sapiens_hsa047220.18562889
152Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.16751697
153Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16513295
154Non-small cell lung cancer_Homo sapiens_hsa052230.14121453
155Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.13744930
156Melanoma_Homo sapiens_hsa052180.12415074
157Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.11878656
158Renal cell carcinoma_Homo sapiens_hsa052110.11205211
159Thyroid hormone signaling pathway_Homo sapiens_hsa049190.10274378

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