CALM2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.88239964
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.56843233
3one-carbon compound transport (GO:0019755)5.44230968
4ATP synthesis coupled proton transport (GO:0015986)5.34091574
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.34091574
6aldehyde catabolic process (GO:0046185)5.24529800
7respiratory electron transport chain (GO:0022904)5.16246870
8electron transport chain (GO:0022900)5.10907506
9protein-cofactor linkage (GO:0018065)4.37099710
10proteasome assembly (GO:0043248)4.31449238
11respiratory chain complex IV assembly (GO:0008535)4.19700897
12tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.13736324
13RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.13736324
14protein neddylation (GO:0045116)4.10064238
15maturation of 5.8S rRNA (GO:0000460)4.10053111
16platelet dense granule organization (GO:0060155)4.07204213
17histone mRNA metabolic process (GO:0008334)4.00030031
18exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.93601795
19vascular smooth muscle contraction (GO:0014829)3.91863011
20protein complex biogenesis (GO:0070271)3.89817731
21hepatocyte apoptotic process (GO:0097284)3.80238359
22nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.79322434
23potassium ion homeostasis (GO:0055075)3.78860016
24preassembly of GPI anchor in ER membrane (GO:0016254)3.77590062
25artery smooth muscle contraction (GO:0014824)3.75794926
26short-term memory (GO:0007614)3.70374093
27chaperone-mediated protein transport (GO:0072321)3.63943023
28regulation of oxidative phosphorylation (GO:0002082)3.63219064
29cytochrome complex assembly (GO:0017004)3.60778154
30mitochondrial respiratory chain complex assembly (GO:0033108)3.54370501
31oxidative phosphorylation (GO:0006119)3.54191286
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.53543062
33mitochondrial respiratory chain complex I assembly (GO:0032981)3.53543062
34NADH dehydrogenase complex assembly (GO:0010257)3.53543062
35maturation of SSU-rRNA (GO:0030490)3.49443400
36regulation of germinal center formation (GO:0002634)3.46637271
37base-excision repair, AP site formation (GO:0006285)3.43945278
38G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.34271257
39neural tube formation (GO:0001841)3.30257089
40hydrogen ion transmembrane transport (GO:1902600)3.29531065
41ATP biosynthetic process (GO:0006754)3.27002927
42tonic smooth muscle contraction (GO:0014820)3.23265322
43purine nucleoside triphosphate biosynthetic process (GO:0009145)3.22479520
44C-terminal protein lipidation (GO:0006501)3.20489295
45establishment of protein localization to mitochondrial membrane (GO:0090151)3.19837931
46ribosomal large subunit biogenesis (GO:0042273)3.16246811
47negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.11777007
48DNA deamination (GO:0045006)3.09378315
49positive regulation of macrophage differentiation (GO:0045651)3.09297765
50hydrogen transport (GO:0006818)3.06710557
51proton transport (GO:0015992)3.05607534
52negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.01572342
53neutrophil activation involved in immune response (GO:0002283)3.00824566
54purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.98571160
55heme transport (GO:0015886)2.97595639
56C4-dicarboxylate transport (GO:0015740)2.94901868
57positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.93289411
58anterograde synaptic vesicle transport (GO:0048490)2.93176464
59regulation of triglyceride catabolic process (GO:0010896)2.91767107
60C-terminal protein amino acid modification (GO:0018410)2.91184048
61cullin deneddylation (GO:0010388)2.88264422
62DNA catabolic process, exonucleolytic (GO:0000738)2.85805081
63regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.82576905
64establishment of integrated proviral latency (GO:0075713)2.82274665
65positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.75991975
66regulation of sister chromatid cohesion (GO:0007063)2.73115729
67ribonucleoside triphosphate biosynthetic process (GO:0009201)2.72073225
68tryptophan metabolic process (GO:0006568)2.71280253
69regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.69585880
70nucleoside triphosphate biosynthetic process (GO:0009142)2.69261468
71negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.69245061
72negative regulation of ligase activity (GO:0051352)2.69245061
73positive regulation of ligase activity (GO:0051351)2.67764965
74purine deoxyribonucleotide catabolic process (GO:0009155)2.66588907
75antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.66265326
76mismatch repair (GO:0006298)2.65671503
77protein prenylation (GO:0018342)2.65089074
78prenylation (GO:0097354)2.65089074
79positive regulation of cardiac muscle hypertrophy (GO:0010613)2.64330036
80positive regulation of muscle hypertrophy (GO:0014742)2.64330036
81regulation of cellular amino acid metabolic process (GO:0006521)2.64283837
82RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.63512637
83spliceosomal complex assembly (GO:0000245)2.60156222
84positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.59252099
85antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.58751444
86adenosine metabolic process (GO:0046085)2.58335864
87DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.58137920
88RNA phosphodiester bond hydrolysis (GO:0090501)2.58064642
89signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.57723241
90signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.57723241
91signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.57723241
92response to nitrosative stress (GO:0051409)2.56697183
93histone mRNA catabolic process (GO:0071044)2.56681162
94protein targeting to mitochondrion (GO:0006626)2.53556930
95translation (GO:0006412)2.53220325
96innate immune response in mucosa (GO:0002227)2.52599494
97auditory receptor cell stereocilium organization (GO:0060088)2.52483681
98indolalkylamine metabolic process (GO:0006586)2.51973729
99regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.51028178
100gonadal mesoderm development (GO:0007506)10.3541916

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.17116720
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.66915960
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.53832000
4TAF15_26573619_Chip-Seq_HEK293_Human3.13896717
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.01096878
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.70454556
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.61866318
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.48599224
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.45938825
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.41912954
11ELK1_19687146_ChIP-ChIP_HELA_Human2.40851950
12VDR_22108803_ChIP-Seq_LS180_Human2.31932809
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.21937866
14HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.16405775
15FUS_26573619_Chip-Seq_HEK293_Human2.14832948
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.12536566
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.10336549
18EWS_26573619_Chip-Seq_HEK293_Human2.03659544
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97459686
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.96586349
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96352212
22ZNF274_21170338_ChIP-Seq_K562_Hela1.94532892
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91889413
24P300_19829295_ChIP-Seq_ESCs_Human1.87736440
25VDR_23849224_ChIP-Seq_CD4+_Human1.87188216
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.84642169
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79923485
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79720967
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.79450296
30MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.78304260
31GBX2_23144817_ChIP-Seq_PC3_Human1.75384763
32TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71013239
33POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.71013239
34POU5F1_16153702_ChIP-ChIP_HESCs_Human1.66550746
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65768811
36SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61374314
37MYC_18555785_ChIP-Seq_MESCs_Mouse1.59780959
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.57294506
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56650548
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.49652583
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.45252843
42POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43832219
43BCAT_22108803_ChIP-Seq_LS180_Human1.43701476
44RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.43612567
45ELK1_22589737_ChIP-Seq_MCF10A_Human1.42550594
46FOXH1_21741376_ChIP-Seq_EPCs_Human1.40675809
47EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.40219319
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39730587
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.39182956
50HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.38055263
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37937560
52MYC_18940864_ChIP-ChIP_HL60_Human1.31452469
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29384134
54TCF4_22108803_ChIP-Seq_LS180_Human1.29052299
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27902423
56FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25506872
57FOXP3_21729870_ChIP-Seq_TREG_Human1.24713913
58TP53_22573176_ChIP-Seq_HFKS_Human1.24583073
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23390294
60NANOG_19829295_ChIP-Seq_ESCs_Human1.22182408
61SOX2_19829295_ChIP-Seq_ESCs_Human1.22182408
62ER_23166858_ChIP-Seq_MCF-7_Human1.21399642
63CRX_20693478_ChIP-Seq_RETINA_Mouse1.21386469
64FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20727173
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.20727173
66OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19212266
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17924428
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17204332
69ERG_20517297_ChIP-Seq_VCAP_Human1.16631871
70CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14036338
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13981825
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11360130
73SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09995851
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09626041
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09392957
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.07651404
77AR_20517297_ChIP-Seq_VCAP_Human1.06473492
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.05819233
79PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.04628034
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03891228
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03817464
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03740531
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03704276
84SALL4_22934838_ChIP-ChIP_CD34+_Human1.03124013
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03094709
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02085007
87HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00966265
88JUN_21703547_ChIP-Seq_K562_Human1.00704584
89TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99937160
90CDX2_22108803_ChIP-Seq_LS180_Human0.99512395
91NANOG_16153702_ChIP-ChIP_HESCs_Human0.98962842
92SMAD4_21799915_ChIP-Seq_A2780_Human0.98880137
93MYC_18358816_ChIP-ChIP_MESCs_Mouse0.98513474
94BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98311603
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97537550
96TAL1_26923725_Chip-Seq_HPCs_Mouse0.97451882
97RBPJ_21746931_ChIP-Seq_IB4_Human0.96729022
98GATA3_21878914_ChIP-Seq_MCF-7_Human0.96424979
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96036301
100CBP_20019798_ChIP-Seq_JUKART_Human0.96036301

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis6.21260571
2MP0000372_irregular_coat_pigmentation4.80256803
3MP0004147_increased_porphyrin_level4.18258135
4MP0000516_abnormal_urinary_system3.88183831
5MP0005367_renal/urinary_system_phenotyp3.88183831
6MP0008057_abnormal_DNA_replication3.30659723
7MP0008877_abnormal_DNA_methylation3.17480804
8MP0006054_spinal_hemorrhage2.75097416
9MP0008875_abnormal_xenobiotic_pharmacok2.42007273
10MP0008872_abnormal_physiological_respon2.40643434
11MP0005408_hypopigmentation2.36996443
12MP0002837_dystrophic_cardiac_calcinosis2.27144866
13MP0006036_abnormal_mitochondrial_physio2.12941704
14MP0003195_calcinosis2.11985331
15MP0009764_decreased_sensitivity_to2.03645746
16MP0005075_abnormal_melanosome_morpholog2.02970756
17MP0009379_abnormal_foot_pigmentation1.90930626
18MP0005671_abnormal_response_to1.82632385
19MP0005085_abnormal_gallbladder_physiolo1.81107658
20MP0009697_abnormal_copulation1.79224781
21MP0004215_abnormal_myocardial_fiber1.71381886
22MP0004742_abnormal_vestibular_system1.69506678
23MP0002163_abnormal_gland_morphology1.65967145
24MP0003252_abnormal_bile_duct1.62579416
25MP0002396_abnormal_hematopoietic_system1.60142585
26MP0001727_abnormal_embryo_implantation1.59934623
27MP0006072_abnormal_retinal_apoptosis1.56832249
28MP0009046_muscle_twitch1.55692993
29MP0002234_abnormal_pharynx_morphology1.55362406
30MP0002938_white_spotting1.53206541
31MP0005551_abnormal_eye_electrophysiolog1.50593860
32MP0001486_abnormal_startle_reflex1.46133927
33MP0001529_abnormal_vocalization1.45903925
34MP0001984_abnormal_olfaction1.43015698
35MP0005266_abnormal_metabolism1.42320067
36MP0002736_abnormal_nociception_after1.41583028
37MP0008995_early_reproductive_senescence1.38275948
38MP0001501_abnormal_sleep_pattern1.32091637
39MP0006035_abnormal_mitochondrial_morpho1.30006553
40MP0004019_abnormal_vitamin_homeostasis1.28525498
41MP0005646_abnormal_pituitary_gland1.26965660
42MP0001835_abnormal_antigen_presentation1.24674116
43MP0005379_endocrine/exocrine_gland_phen1.23048706
44MP0002102_abnormal_ear_morphology1.20052788
45MP0002272_abnormal_nervous_system1.19806664
46MP0001485_abnormal_pinna_reflex1.15763038
47MP0010386_abnormal_urinary_bladder1.10229851
48MP0003011_delayed_dark_adaptation1.09997329
49MP0003137_abnormal_impulse_conducting1.09564111
50MP0003880_abnormal_central_pattern1.08654371
51MP0001968_abnormal_touch/_nociception1.08005318
52MP0002148_abnormal_hypersensitivity_rea0.98215643
53MP0002160_abnormal_reproductive_system0.97185031
54MP0001756_abnormal_urination0.96494328
55MP0002006_tumorigenesis0.95667542
56MP0002734_abnormal_mechanical_nocicepti0.95628103
57MP0003638_abnormal_response/metabolism_0.94639740
58MP0008058_abnormal_DNA_repair0.93784584
59MP0002254_reproductive_system_inflammat0.93783616
60MP0004142_abnormal_muscle_tone0.93299695
61MP0003890_abnormal_embryonic-extraembry0.92491815
62MP0003787_abnormal_imprinting0.91769740
63MP0002751_abnormal_autonomic_nervous0.88789531
64MP0001970_abnormal_pain_threshold0.88628779
65MP0005174_abnormal_tail_pigmentation0.88370284
66MP0009785_altered_susceptibility_to0.87079747
67MP0005166_decreased_susceptibility_to0.86580851
68MP0001440_abnormal_grooming_behavior0.84326317
69MP0000534_abnormal_ureter_morphology0.83370149
70MP0002090_abnormal_vision0.82966927
71MP0001764_abnormal_homeostasis0.81491974
72MP0005410_abnormal_fertilization0.81313707
73MP0005253_abnormal_eye_physiology0.78487662
74MP0005332_abnormal_amino_acid0.78367764
75MP0003718_maternal_effect0.77281944
76MP0005389_reproductive_system_phenotype0.76088874
77MP0000685_abnormal_immune_system0.74790143
78MP0006292_abnormal_olfactory_placode0.74133063
79MP0003646_muscle_fatigue0.73762416
80MP0005084_abnormal_gallbladder_morpholo0.72993379
81MP0003693_abnormal_embryo_hatching0.72614998
82MP0005645_abnormal_hypothalamus_physiol0.72011526
83MP0003136_yellow_coat_color0.70521597
84MP0002928_abnormal_bile_duct0.69881669
85MP0008775_abnormal_heart_ventricle0.69630483
86MP0006276_abnormal_autonomic_nervous0.68471164
87MP0005360_urolithiasis0.67840427
88MP0005636_abnormal_mineral_homeostasis0.67388147
89MP0003567_abnormal_fetal_cardiomyocyte0.66811817
90MP0000639_abnormal_adrenal_gland0.64927208
91MP0000647_abnormal_sebaceous_gland0.64329291
92MP0009745_abnormal_behavioral_response0.62111429
93MP0005535_abnormal_body_temperature0.61585557
94MP0004484_altered_response_of0.60596764
95MP0008873_increased_physiological_sensi0.60575141
96MP0005365_abnormal_bile_salt0.60281471
97MP0001542_abnormal_bone_strength0.58127850
98MP0004084_abnormal_cardiac_muscle0.57852784
99MP0001905_abnormal_dopamine_level0.56960423
100MP0010094_abnormal_chromosome_stability0.56852449

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.48080798
2Mitochondrial inheritance (HP:0001427)5.97164066
3Hepatocellular necrosis (HP:0001404)5.85799086
4Acute encephalopathy (HP:0006846)5.75696771
5Abnormal mitochondria in muscle tissue (HP:0008316)5.63758075
6Progressive macrocephaly (HP:0004481)5.53181262
7Increased CSF lactate (HP:0002490)5.43545641
8Hepatic necrosis (HP:0002605)5.09708907
9Congenital, generalized hypertrichosis (HP:0004540)5.07614503
10Cerebral edema (HP:0002181)4.21282676
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.13142819
12Decreased activity of mitochondrial respiratory chain (HP:0008972)4.13142819
13Increased hepatocellular lipid droplets (HP:0006565)3.83849167
14Leukodystrophy (HP:0002415)3.72705272
15Type I transferrin isoform profile (HP:0003642)3.68854880
16Hypothermia (HP:0002045)3.67626548
17Lipid accumulation in hepatocytes (HP:0006561)3.66952962
18Respiratory failure (HP:0002878)3.56882717
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.41775050
203-Methylglutaconic aciduria (HP:0003535)3.27421493
21Lactic acidosis (HP:0003128)3.23594511
22Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.17014912
23Optic disc pallor (HP:0000543)3.12106035
24Increased serum lactate (HP:0002151)3.10531829
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.09901019
26Increased intramyocellular lipid droplets (HP:0012240)2.92000095
27Woolly hair (HP:0002224)2.75152991
28Progressive microcephaly (HP:0000253)2.73766954
29Sensory axonal neuropathy (HP:0003390)2.72244610
30Amniotic constriction ring (HP:0009775)2.72039110
31Abnormality of placental membranes (HP:0011409)2.72039110
32X-linked dominant inheritance (HP:0001423)2.71623358
33CNS demyelination (HP:0007305)2.68621168
34Exercise intolerance (HP:0003546)2.62783605
35Exertional dyspnea (HP:0002875)2.60009762
36Myokymia (HP:0002411)2.53060527
37Increased muscle lipid content (HP:0009058)2.48953375
38Abnormality of renal resorption (HP:0011038)2.47975861
39Renal Fanconi syndrome (HP:0001994)2.46999697
40Chronic diarrhea (HP:0002028)2.39375059
41Congenital ichthyosiform erythroderma (HP:0007431)2.36852046
42Abnormal protein glycosylation (HP:0012346)2.36053473
43Abnormal glycosylation (HP:0012345)2.36053473
44Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.36053473
45Abnormal protein N-linked glycosylation (HP:0012347)2.36053473
46Emotional lability (HP:0000712)2.28010421
47Delayed CNS myelination (HP:0002188)2.21633564
48Reduced antithrombin III activity (HP:0001976)2.17463896
49Lethargy (HP:0001254)2.16847479
50Palpitations (HP:0001962)2.11875254
51Elevated erythrocyte sedimentation rate (HP:0003565)2.10732019
52Facial diplegia (HP:0001349)2.08221002
53Aplasia cutis congenita (HP:0001057)2.07876409
54Abnormal rod and cone electroretinograms (HP:0008323)2.06948370
55Glycosuria (HP:0003076)2.06259732
56Abnormality of urine glucose concentration (HP:0011016)2.06259732
57Febrile seizures (HP:0002373)2.06198111
58Respiratory difficulties (HP:0002880)2.04807228
59Abnormality of abdominal situs (HP:0011620)2.03831841
60Abdominal situs inversus (HP:0003363)2.03831841
61Delayed gross motor development (HP:0002194)1.97009330
62Dry hair (HP:0011359)1.96393308
63Medial flaring of the eyebrow (HP:0010747)1.90384480
64Blindness (HP:0000618)1.89097096
65Intestinal atresia (HP:0011100)1.84748076
66Abnormality of alanine metabolism (HP:0010916)1.81692439
67Hyperalaninemia (HP:0003348)1.81692439
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81692439
69Tetany (HP:0001281)1.81335352
70Delayed myelination (HP:0012448)1.80983394
71Limb dystonia (HP:0002451)1.80146572
72Atonic seizures (HP:0010819)1.78782261
73Hypoproteinemia (HP:0003075)1.78326972
74Nausea (HP:0002018)1.77742959
75Petechiae (HP:0000967)1.76259193
76Poor suck (HP:0002033)1.71224115
77Abnormality of aspartate family amino acid metabolism (HP:0010899)1.71029462
78Spastic paraparesis (HP:0002313)1.70508772
79Sclerocornea (HP:0000647)1.70021047
80Reticulocytopenia (HP:0001896)1.69996004
81Decreased central vision (HP:0007663)1.68956538
82Hypomagnesemia (HP:0002917)1.68831111
83Congenital stationary night blindness (HP:0007642)1.68684716
84Abnormality of T cell physiology (HP:0011840)1.68547989
85Adrenal hypoplasia (HP:0000835)1.68457429
86Male pseudohermaphroditism (HP:0000037)1.68185433
87Increased corneal curvature (HP:0100692)1.67676976
88Keratoconus (HP:0000563)1.67676976
89Small hand (HP:0200055)1.66786922
90Poor speech (HP:0002465)1.65872519
91Porencephaly (HP:0002132)1.64041215
92Pancreatic cysts (HP:0001737)1.63564344
93Absent hand (HP:0004050)1.62907554
94Vomiting (HP:0002013)1.62656805
95Renal tubular dysfunction (HP:0000124)1.62467716
96Micronodular cirrhosis (HP:0001413)1.62284014
97Intellectual disability, profound (HP:0002187)1.61552057
98Abnormality of magnesium homeostasis (HP:0004921)1.61406769
99Poor head control (HP:0002421)1.60754052
100Abolished electroretinogram (ERG) (HP:0000550)1.59369141

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K125.62134295
2ZAK2.86370257
3MYLK2.82389538
4BMPR1B2.67213225
5FRK2.36968887
6TSSK62.31248890
7MST42.11333370
8VRK22.02923332
9WNK32.00617001
10BMPR21.95247463
11STK161.90045082
12PLK41.87039790
13NUAK11.86673109
14ILK1.85929510
15MAPKAPK31.81713095
16EIF2AK31.67683958
17TIE11.62281822
18CDK81.62192808
19EIF2AK11.60926877
20STK38L1.60789969
21ACVR1B1.56098998
22DAPK11.55351289
23OXSR11.52946830
24TAOK31.45523498
25ADRBK21.39331741
26MAPK131.36273304
27GRK11.28364770
28MKNK21.27404569
29PLK31.26818652
30TEC1.26290423
31STK391.20367768
32CSNK1G21.19981639
33NEK11.16893213
34MAP4K21.15098728
35MAP3K41.14883547
36CSNK1G31.13087950
37ROCK11.10845953
38SRPK11.06599078
39CASK1.03444576
40INSRR1.02036453
41STK241.01827365
42PAK40.99593513
43CCNB10.98217859
44ERBB30.97895434
45DAPK30.97706727
46TRIM280.91051174
47CSNK1G10.89973192
48TNIK0.89735228
49CSNK1A1L0.88661776
50DYRK30.87363278
51CDK190.87054400
52WNK40.86749747
53TGFBR10.86468997
54PDK20.84658017
55PLK20.83038459
56PAK30.80783937
57TAF10.77978520
58CDK30.70903889
59ROCK20.70247333
60MAP2K70.65424525
61PRKCG0.64865957
62IKBKB0.63124876
63DMPK0.60150208
64VRK10.60049523
65PKN10.59456684
66ADRBK10.58972477
67BUB10.58713949
68EIF2AK20.57935384
69CAMK2A0.56236618
70MKNK10.55509538
71PLK10.55129753
72PRKCA0.54497526
73STK100.54304696
74CSNK2A20.53796310
75CSNK2A10.52170951
76PRKCE0.51650488
77ATR0.50759150
78PIM10.49968299
79PBK0.49956326
80PHKG20.49819221
81PHKG10.49819221
82ITK0.49555399
83CAMK2D0.49206830
84IGF1R0.48733040
85ALK0.47320379
86GRK50.46903517
87AKT30.46847754
88MAP4K10.46271171
89LYN0.44735017
90OBSCN0.44622565
91MUSK0.44233117
92DAPK20.43690999
93PRKG10.42920049
94CAMK2G0.41797491
95STK30.41503056
96WEE10.40359800
97KIT0.39931467
98PRKACA0.38740565
99PINK10.37971766
100CSNK1E0.37801473

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.78438309
2Proteasome_Homo sapiens_hsa030503.70265296
3Parkinsons disease_Homo sapiens_hsa050123.64328111
4Protein export_Homo sapiens_hsa030602.96978505
5Alzheimers disease_Homo sapiens_hsa050102.89081163
6Huntingtons disease_Homo sapiens_hsa050162.64551561
7Ribosome_Homo sapiens_hsa030102.62964185
8Sulfur metabolism_Homo sapiens_hsa009202.56947132
9Asthma_Homo sapiens_hsa053102.55080321
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.52089548
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.51673318
12Homologous recombination_Homo sapiens_hsa034402.16266650
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.14850464
14Cardiac muscle contraction_Homo sapiens_hsa042602.13603924
15Collecting duct acid secretion_Homo sapiens_hsa049661.94802234
16Type I diabetes mellitus_Homo sapiens_hsa049401.90691094
17Allograft rejection_Homo sapiens_hsa053301.78791171
18Graft-versus-host disease_Homo sapiens_hsa053321.70804056
19RNA degradation_Homo sapiens_hsa030181.69560265
20Autoimmune thyroid disease_Homo sapiens_hsa053201.69381678
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.68175600
22Nitrogen metabolism_Homo sapiens_hsa009101.65868887
23Rheumatoid arthritis_Homo sapiens_hsa053231.58330522
24Basal transcription factors_Homo sapiens_hsa030221.43816237
25One carbon pool by folate_Homo sapiens_hsa006701.40030536
26Non-homologous end-joining_Homo sapiens_hsa034501.38450100
27DNA replication_Homo sapiens_hsa030301.35585892
28Mismatch repair_Homo sapiens_hsa034301.19013009
29Linoleic acid metabolism_Homo sapiens_hsa005911.10980880
30Base excision repair_Homo sapiens_hsa034101.10064524
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08024768
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05962567
33Viral myocarditis_Homo sapiens_hsa054161.05039547
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01489752
35RNA polymerase_Homo sapiens_hsa030201.00778801
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.97754259
37Ether lipid metabolism_Homo sapiens_hsa005650.95198671
38Nucleotide excision repair_Homo sapiens_hsa034200.94783231
39Selenocompound metabolism_Homo sapiens_hsa004500.94577106
40Pyruvate metabolism_Homo sapiens_hsa006200.93972665
41Tryptophan metabolism_Homo sapiens_hsa003800.89954413
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89696553
43Drug metabolism - other enzymes_Homo sapiens_hsa009830.88051341
44Antigen processing and presentation_Homo sapiens_hsa046120.83178671
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80514912
46Caffeine metabolism_Homo sapiens_hsa002320.79065303
47Regulation of autophagy_Homo sapiens_hsa041400.77182590
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77046962
49RNA transport_Homo sapiens_hsa030130.76186709
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74111291
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71720965
52Phototransduction_Homo sapiens_hsa047440.71138084
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68774094
54Chemical carcinogenesis_Homo sapiens_hsa052040.68234198
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66237537
56Spliceosome_Homo sapiens_hsa030400.64539518
57Propanoate metabolism_Homo sapiens_hsa006400.64467594
58Fanconi anemia pathway_Homo sapiens_hsa034600.64390611
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.63843200
60GABAergic synapse_Homo sapiens_hsa047270.63629330
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63532224
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63489037
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63101958
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62991744
65Staphylococcus aureus infection_Homo sapiens_hsa051500.62429610
66Fatty acid degradation_Homo sapiens_hsa000710.62121714
67Nicotine addiction_Homo sapiens_hsa050330.61987219
68Pyrimidine metabolism_Homo sapiens_hsa002400.60514704
69Metabolic pathways_Homo sapiens_hsa011000.58908370
70Fatty acid elongation_Homo sapiens_hsa000620.56418434
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54800133
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54745033
73Purine metabolism_Homo sapiens_hsa002300.49856561
74Morphine addiction_Homo sapiens_hsa050320.47144222
75p53 signaling pathway_Homo sapiens_hsa041150.46782570
76Vitamin digestion and absorption_Homo sapiens_hsa049770.45538133
77Taste transduction_Homo sapiens_hsa047420.45473132
78Vibrio cholerae infection_Homo sapiens_hsa051100.44982829
79Retinol metabolism_Homo sapiens_hsa008300.44761767
80Legionellosis_Homo sapiens_hsa051340.43085794
81Fat digestion and absorption_Homo sapiens_hsa049750.42568797
82Systemic lupus erythematosus_Homo sapiens_hsa053220.41328656
83Arachidonic acid metabolism_Homo sapiens_hsa005900.37530884
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.37411970
85Mineral absorption_Homo sapiens_hsa049780.35264943
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35220710
87Folate biosynthesis_Homo sapiens_hsa007900.34280883
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33476699
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.31035733
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30833110
91Gastric acid secretion_Homo sapiens_hsa049710.29294244
92Olfactory transduction_Homo sapiens_hsa047400.28744926
93Glutamatergic synapse_Homo sapiens_hsa047240.28421722
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28297173
95Hematopoietic cell lineage_Homo sapiens_hsa046400.26795025
96Synaptic vesicle cycle_Homo sapiens_hsa047210.23627130
97Circadian entrainment_Homo sapiens_hsa047130.22907086
98Phagosome_Homo sapiens_hsa041450.21991927
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.20625019
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19937884

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