CALM2P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00438.44644491
2cellular response to nitric oxide (GO:0071732)7.99507042
3regulation of protein glycosylation (GO:0060049)7.46024201
4regulation of response to food (GO:0032095)7.00558390
5cellular response to leptin stimulus (GO:0044320)6.69187450
6response to leptin (GO:0044321)6.39754970
7cellular zinc ion homeostasis (GO:0006882)6.34878713
8positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003606.24717741
9sterol catabolic process (GO:0016127)6.02449665
10cholesterol catabolic process (GO:0006707)6.02449665
11cellular response to reactive nitrogen species (GO:1902170)5.82396518
12astrocyte development (GO:0014002)5.77158300
13interleukin-6-mediated signaling pathway (GO:0070102)5.63034551
14cellular response to cadmium ion (GO:0071276)5.58928246
15response to nitric oxide (GO:0071731)5.50533583
16negative regulation of necrotic cell death (GO:0060547)5.45303766
17zinc ion homeostasis (GO:0055069)5.32741773
18cellular response to oxygen radical (GO:0071450)4.93572609
19removal of superoxide radicals (GO:0019430)4.93572609
20cellular response to superoxide (GO:0071451)4.93572609
21glutamate secretion (GO:0014047)4.85187132
22neurofilament cytoskeleton organization (GO:0060052)4.46558677
23steroid catabolic process (GO:0006706)4.41084301
24synaptic vesicle exocytosis (GO:0016079)4.37450503
25activation of protein kinase B activity (GO:0032148)4.30727958
26galactose metabolic process (GO:0006012)4.20446586
27establishment of protein localization to Golgi (GO:0072600)4.13326489
28positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)4.12638319
29protein targeting to Golgi (GO:0000042)4.09850483
30negative regulation of appetite (GO:0032099)3.90822129
31negative regulation of response to food (GO:0032096)3.90822129
32response to superoxide (GO:0000303)3.82643031
33vitamin catabolic process (GO:0009111)3.79819693
34fat-soluble vitamin catabolic process (GO:0042363)3.79819693
35glial cell proliferation (GO:0014009)3.77799774
36galactose catabolic process (GO:0019388)3.74850685
37retrograde transport, vesicle recycling within Golgi (GO:0000301)3.73275007
38adaptation of signaling pathway (GO:0023058)3.70258274
39negative regulation of reactive oxygen species metabolic process (GO:2000378)3.67610936
40negative regulation of axon extension (GO:0030517)3.63507536
41gamma-aminobutyric acid signaling pathway (GO:0007214)3.62758068
42urinary tract smooth muscle contraction (GO:0014848)3.54086060
43ionotropic glutamate receptor signaling pathway (GO:0035235)3.53748394
44regulation of sensory perception (GO:0051931)3.46124222
45regulation of sensory perception of pain (GO:0051930)3.46124222
46behavioral fear response (GO:0001662)3.44389965
47behavioral defense response (GO:0002209)3.44389965
48response to oxygen radical (GO:0000305)3.44337609
49glutamate receptor signaling pathway (GO:0007215)3.41922090
50neuronal action potential (GO:0019228)3.38393984
51neuronal action potential propagation (GO:0019227)3.34618416
52positive regulation of potassium ion transmembrane transport (GO:1901381)3.33749733
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.30621567
54zinc ion transport (GO:0006829)3.30204323
55cellular response to electrical stimulus (GO:0071257)3.27873442
56sleep (GO:0030431)3.27249257
57telomere maintenance via telomerase (GO:0007004)3.19358688
58ERK1 and ERK2 cascade (GO:0070371)3.16714600
59regulation of establishment of cell polarity (GO:2000114)3.14124355
60substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.11610281
61substrate-independent telencephalic tangential migration (GO:0021826)3.11610281
62protein localization to synapse (GO:0035418)3.09100024
63detection of calcium ion (GO:0005513)3.06727514
64regulation of cell communication by electrical coupling (GO:0010649)3.06494737
65fear response (GO:0042596)3.05372716
66startle response (GO:0001964)3.02352004
67protein localization to Golgi apparatus (GO:0034067)2.97592089
68neurotransmitter secretion (GO:0007269)2.96001996
69negative regulation of oxidoreductase activity (GO:0051354)2.95592786
70synaptic transmission, glutamatergic (GO:0035249)2.95322923
71Golgi to plasma membrane protein transport (GO:0043001)2.92597653
72positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.91811519
73negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.88236600
74gamma-aminobutyric acid transport (GO:0015812)2.87898633
75protein-cofactor linkage (GO:0018065)2.87720779
76positive regulation of synapse maturation (GO:0090129)2.86407609
77positive regulation of potassium ion transport (GO:0043268)2.84567813
78magnesium ion transport (GO:0015693)2.83815484
79regulation of voltage-gated calcium channel activity (GO:1901385)2.83625606
80negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.83214445
81calcium ion-dependent exocytosis (GO:0017156)2.82959481
82protein import into nucleus, translocation (GO:0000060)2.82781504
83positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.78017222
84cellular anion homeostasis (GO:0030002)2.77940107
85relaxation of smooth muscle (GO:0044557)2.75482758
86regulation of mitochondrial depolarization (GO:0051900)2.74361989
87response to amphetamine (GO:0001975)2.72303175
88regulation of necrotic cell death (GO:0010939)2.69751068
89photoreceptor cell differentiation (GO:0046530)2.68811636
90eye photoreceptor cell differentiation (GO:0001754)2.68811636
91vitamin D metabolic process (GO:0042359)2.66986168
92behavioral response to cocaine (GO:0048148)2.65706486
93response to histamine (GO:0034776)2.62413608
94regulation of potassium ion transport (GO:0043266)2.62335430
95N-glycan processing (GO:0006491)2.60821617
96positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.60272270
97neuron-neuron synaptic transmission (GO:0007270)2.59917630
98regulation of potassium ion transmembrane transport (GO:1901379)2.57309701
99single strand break repair (GO:0000012)2.56029267
100long-term synaptic potentiation (GO:0060291)2.52914873

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.08357293
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.04868946
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.41229943
4TAF15_26573619_Chip-Seq_HEK293_Human3.40704547
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.30212593
6GBX2_23144817_ChIP-Seq_PC3_Human3.26341135
7ZFP57_27257070_Chip-Seq_ESCs_Mouse3.04816999
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.73844311
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.73276985
10VDR_22108803_ChIP-Seq_LS180_Human2.71563695
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.43411868
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.23593733
13P300_19829295_ChIP-Seq_ESCs_Human2.05795677
14FUS_26573619_Chip-Seq_HEK293_Human2.03809363
15REST_21632747_ChIP-Seq_MESCs_Mouse2.02158149
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01723732
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.96585191
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90604434
19EWS_26573619_Chip-Seq_HEK293_Human1.90224191
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87722261
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.82062116
22HTT_18923047_ChIP-ChIP_STHdh_Human1.81639348
23SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73586851
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.72674676
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.71846265
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71683418
27SMAD4_21799915_ChIP-Seq_A2780_Human1.71211593
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.69799553
29AR_21572438_ChIP-Seq_LNCaP_Human1.67583254
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.63937324
31IGF1R_20145208_ChIP-Seq_DFB_Human1.63021934
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62362388
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57796939
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56947895
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52996919
36CBP_20019798_ChIP-Seq_JUKART_Human1.52626795
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52626795
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.50335339
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.47814346
40OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44400798
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43220681
42TCF4_23295773_ChIP-Seq_U87_Human1.42431741
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41913046
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41246453
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41079863
46TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.38759876
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.37211439
48STAT3_23295773_ChIP-Seq_U87_Human1.37076169
49AR_25329375_ChIP-Seq_VCAP_Human1.35773552
50BCAT_22108803_ChIP-Seq_LS180_Human1.35763116
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35311375
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.32814164
53GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31856189
54EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31168790
55RNF2_27304074_Chip-Seq_NSC_Mouse1.30620279
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.29669027
57FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.29525146
58PRDM14_20953172_ChIP-Seq_ESCs_Human1.28286868
59RUNX2_22187159_ChIP-Seq_PCA_Human1.28259380
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24600184
61FLI1_21867929_ChIP-Seq_TH2_Mouse1.23890436
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22944501
63CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.22234810
64TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.19652102
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17939996
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17592416
67LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17021425
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16741657
69RARB_27405468_Chip-Seq_BRAIN_Mouse1.16589102
70JUN_21703547_ChIP-Seq_K562_Human1.16259321
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.15887221
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15288362
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.15273828
74SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.15241989
75NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15144582
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.14467109
77NANOG_19829295_ChIP-Seq_ESCs_Human1.14346744
78SOX2_19829295_ChIP-Seq_ESCs_Human1.14346744
79TP53_22573176_ChIP-Seq_HFKS_Human1.12770403
80MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12722869
81CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11355981
82JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10566061
83ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10229678
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08673293
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08673293
86P53_22387025_ChIP-Seq_ESCs_Mouse1.08670180
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07828684
88SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07374422
89SMAD3_21741376_ChIP-Seq_ESCs_Human1.06747068
90MYC_18940864_ChIP-ChIP_HL60_Human1.05839361
91ZNF274_21170338_ChIP-Seq_K562_Hela1.05756292
92SOX2_21211035_ChIP-Seq_LN229_Gbm1.05010808
93EZH2_27304074_Chip-Seq_ESCs_Mouse1.02666235
94ER_23166858_ChIP-Seq_MCF-7_Human1.01129001
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.00888914
96SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00488944
97TAL1_26923725_Chip-Seq_HPCs_Mouse0.99330034
98TCF4_22108803_ChIP-Seq_LS180_Human0.98264666
99CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95740829
100EZH2_27294783_Chip-Seq_ESCs_Mouse0.94661009

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.19057828
2MP0003787_abnormal_imprinting3.87415886
3MP0002064_seizures2.97511784
4MP0001968_abnormal_touch/_nociception2.96820443
5MP0009745_abnormal_behavioral_response2.90500045
6MP0004147_increased_porphyrin_level2.90091290
7MP0009780_abnormal_chondrocyte_physiolo2.89727801
8MP0004043_abnormal_pH_regulation2.77034438
9MP0009046_muscle_twitch2.75427863
10MP0004885_abnormal_endolymph2.73464260
11MP0003635_abnormal_synaptic_transmissio2.69762369
12MP0002272_abnormal_nervous_system2.63532368
13MP0005646_abnormal_pituitary_gland2.61573857
14MP0002736_abnormal_nociception_after2.61066464
15MP0001188_hyperpigmentation2.54264170
16MP0004859_abnormal_synaptic_plasticity2.45160797
17MP0001501_abnormal_sleep_pattern2.35534535
18MP0003880_abnormal_central_pattern2.27428802
19MP0004270_analgesia2.03804201
20MP0001486_abnormal_startle_reflex2.03415680
21MP0002063_abnormal_learning/memory/cond2.01877586
22MP0005551_abnormal_eye_electrophysiolog2.00084302
23MP0001984_abnormal_olfaction1.91884933
24MP0002735_abnormal_chemical_nociception1.83414094
25MP0002733_abnormal_thermal_nociception1.75293057
26MP0002572_abnormal_emotion/affect_behav1.75159347
27MP0010386_abnormal_urinary_bladder1.70054241
28MP0006072_abnormal_retinal_apoptosis1.65907147
29MP0000569_abnormal_digit_pigmentation1.63659893
30MP0002837_dystrophic_cardiac_calcinosis1.63021321
31MP0001905_abnormal_dopamine_level1.58222847
32MP0002089_abnormal_postnatal_growth/wei1.57312067
33MP0001764_abnormal_homeostasis1.56113060
34MP0001970_abnormal_pain_threshold1.49554493
35MP0002734_abnormal_mechanical_nocicepti1.43948298
36MP0001440_abnormal_grooming_behavior1.43183045
37MP0002067_abnormal_sensory_capabilities1.42099419
38MP0005636_abnormal_mineral_homeostasis1.39572551
39MP0003121_genomic_imprinting1.39553148
40MP0001485_abnormal_pinna_reflex1.37187093
41MP0003183_abnormal_peptide_metabolism1.37022986
42MP0004742_abnormal_vestibular_system1.32851802
43MP0003633_abnormal_nervous_system1.28229736
44MP0001542_abnormal_bone_strength1.27895537
45MP0000955_abnormal_spinal_cord1.25526153
46MP0008875_abnormal_xenobiotic_pharmacok1.24956747
47MP0001502_abnormal_circadian_rhythm1.22631044
48MP0000631_abnormal_neuroendocrine_gland1.21133102
49MP0005645_abnormal_hypothalamus_physiol1.17351068
50MP0000604_amyloidosis1.17232170
51MP0008872_abnormal_physiological_respon1.17219887
52MP0001765_abnormal_ion_homeostasis1.13881768
53MP0006276_abnormal_autonomic_nervous1.11565482
54MP0004924_abnormal_behavior1.10576524
55MP0005386_behavior/neurological_phenoty1.10576524
56MP0008057_abnormal_DNA_replication1.08748315
57MP0005084_abnormal_gallbladder_morpholo1.07696613
58MP0001963_abnormal_hearing_physiology1.07496592
59MP0003631_nervous_system_phenotype1.06780943
60MP0005671_abnormal_response_to1.04339827
61MP0002557_abnormal_social/conspecific_i1.03003612
62MP0002882_abnormal_neuron_morphology1.03003565
63MP0004811_abnormal_neuron_physiology1.01812742
64MP0003879_abnormal_hair_cell1.01164977
65MP0003122_maternal_imprinting1.00639535
66MP0003045_fibrosis1.00387619
67MP0005253_abnormal_eye_physiology0.99807035
68MP0002396_abnormal_hematopoietic_system0.99731015
69MP0002066_abnormal_motor_capabilities/c0.99691008
70MP0008995_early_reproductive_senescence0.98731217
71MP0003329_amyloid_beta_deposits0.97814301
72MP0005389_reproductive_system_phenotype0.97488588
73MP0002160_abnormal_reproductive_system0.95640531
74MP0003011_delayed_dark_adaptation0.93359479
75MP0002138_abnormal_hepatobiliary_system0.92800846
76MP0002229_neurodegeneration0.91798282
77MP0001177_atelectasis0.89899119
78MP0002095_abnormal_skin_pigmentation0.89445927
79MP0000778_abnormal_nervous_system0.87283658
80MP0006036_abnormal_mitochondrial_physio0.84501667
81MP0002752_abnormal_somatic_nervous0.82381295
82MP0006292_abnormal_olfactory_placode0.82262990
83MP0002184_abnormal_innervation0.80520353
84MP0008569_lethality_at_weaning0.79602726
85MP0000920_abnormal_myelination0.79391332
86MP0002909_abnormal_adrenal_gland0.76805471
87MP0003632_abnormal_nervous_system0.76695226
88MP0004134_abnormal_chest_morphology0.75492659
89MP0003690_abnormal_glial_cell0.75075895
90MP0008961_abnormal_basal_metabolism0.74150749
91MP0004133_heterotaxia0.73396543
92MP0000639_abnormal_adrenal_gland0.71821681
93MP0001851_eye_inflammation0.71592224
94MP0004142_abnormal_muscle_tone0.70162409
95MP0001919_abnormal_reproductive_system0.67400583
96MP0004215_abnormal_myocardial_fiber0.66141901
97MP0005376_homeostasis/metabolism_phenot0.64673320
98MP0004019_abnormal_vitamin_homeostasis0.64412796
99MP0000026_abnormal_inner_ear0.64122587
100MP0005535_abnormal_body_temperature0.63839905

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)6.36013795
2Atonic seizures (HP:0010819)5.16259691
3Volvulus (HP:0002580)5.15823529
4Focal seizures (HP:0007359)4.78873102
5Focal motor seizures (HP:0011153)4.69192727
6Action tremor (HP:0002345)4.13557370
7Pigmentary retinal degeneration (HP:0001146)3.97978174
8Absence seizures (HP:0002121)3.93082464
9Diplopia (HP:0000651)3.82440640
10Abnormality of binocular vision (HP:0011514)3.82440640
11Osteomalacia (HP:0002749)3.81012504
12Dialeptic seizures (HP:0011146)3.75936253
13Febrile seizures (HP:0002373)3.68497555
14Acute necrotizing encephalopathy (HP:0006965)3.42948802
15Progressive cerebellar ataxia (HP:0002073)3.39913370
16Abnormality of renal resorption (HP:0011038)3.32862355
17Abnormality of midbrain morphology (HP:0002418)3.28969525
18Molar tooth sign on MRI (HP:0002419)3.28969525
19Epileptic encephalopathy (HP:0200134)3.14168905
20Gaze-evoked nystagmus (HP:0000640)3.10695345
21Progressive macrocephaly (HP:0004481)3.07988500
22Abnormal mitochondria in muscle tissue (HP:0008316)3.00667851
23Pancreatic fibrosis (HP:0100732)2.99073794
24Hemiparesis (HP:0001269)2.96414425
25Ventricular fibrillation (HP:0001663)2.96335622
26Vascular calcification (HP:0004934)2.88251943
27Generalized tonic-clonic seizures (HP:0002069)2.82353681
28Nephronophthisis (HP:0000090)2.75822968
29Acute encephalopathy (HP:0006846)2.74522039
30Limb dystonia (HP:0002451)2.64795509
31Myokymia (HP:0002411)2.60001594
32Medial flaring of the eyebrow (HP:0010747)2.51427905
33Nonprogressive disorder (HP:0003680)2.46645612
34Oligodactyly (hands) (HP:0001180)2.45318712
35Cardiovascular calcification (HP:0011915)2.43988159
36Spinal canal stenosis (HP:0003416)2.43416550
37Status epilepticus (HP:0002133)2.41787783
38Renal cortical cysts (HP:0000803)2.39646972
39Papilledema (HP:0001085)2.36640265
40Abnormality of the renal medulla (HP:0100957)2.34860603
41Epileptiform EEG discharges (HP:0011182)2.30690573
42Mitochondrial inheritance (HP:0001427)2.27680259
43Hyperphosphatemia (HP:0002905)2.26695144
44Congenital stationary night blindness (HP:0007642)2.25295596
45True hermaphroditism (HP:0010459)2.23286845
46Premature ovarian failure (HP:0008209)2.23040994
47Incomplete penetrance (HP:0003829)2.19681791
48Pancreatic cysts (HP:0001737)2.18352355
49Broad-based gait (HP:0002136)2.18340593
50Drooling (HP:0002307)2.15539024
51Dyskinesia (HP:0100660)2.14514215
52Hyperventilation (HP:0002883)2.14405001
53Leukodystrophy (HP:0002415)2.12828093
54Cerebral edema (HP:0002181)2.11508870
55Genetic anticipation (HP:0003743)2.07987045
56Sensory axonal neuropathy (HP:0003390)2.05672211
57Protruding tongue (HP:0010808)2.04224413
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.02224124
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.02224124
60Type 2 muscle fiber atrophy (HP:0003554)2.00937557
61Intention tremor (HP:0002080)1.99769846
62Excessive salivation (HP:0003781)1.98801230
63Specific learning disability (HP:0001328)1.98235945
64Gait imbalance (HP:0002141)1.97985694
65Postural instability (HP:0002172)1.96725117
66Ulnar claw (HP:0001178)1.96418803
67Nephrogenic diabetes insipidus (HP:0009806)1.96220140
68Congenital, generalized hypertrichosis (HP:0004540)1.92003841
69Abnormality of the renal cortex (HP:0011035)1.91999510
70Agnosia (HP:0010524)1.88776187
71Abolished electroretinogram (ERG) (HP:0000550)1.82820583
72Congenital primary aphakia (HP:0007707)1.82539812
73Generalized myoclonic seizures (HP:0002123)1.81692287
74Dysmetria (HP:0001310)1.80977289
753-Methylglutaconic aciduria (HP:0003535)1.79644461
76Truncal ataxia (HP:0002078)1.78888223
77Constricted visual fields (HP:0001133)1.78421036
78X-linked dominant inheritance (HP:0001423)1.76443407
79Optic disc pallor (HP:0000543)1.76248522
80Abnormal urine phosphate concentration (HP:0012599)1.75441668
81Abnormal eating behavior (HP:0100738)1.72866244
82Abnormality of renal excretion (HP:0011036)1.71472603
83Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.69507107
84Furrowed tongue (HP:0000221)1.68362009
85Hypochromic microcytic anemia (HP:0004840)1.68079926
86Lissencephaly (HP:0001339)1.67786377
87Impaired vibration sensation in the lower limbs (HP:0002166)1.67603228
88Neoplasm of the tracheobronchial system (HP:0100552)1.67355342
89Inability to walk (HP:0002540)1.66915972
90Exotropia (HP:0000577)1.66522108
91Increased CSF lactate (HP:0002490)1.65720886
92Confusion (HP:0001289)1.65270220
93Dysdiadochokinesis (HP:0002075)1.64027007
94Prostate neoplasm (HP:0100787)1.63294668
95Abnormality of the prostate (HP:0008775)1.62527005
96Anxiety (HP:0000739)1.61013055
97EEG with generalized epileptiform discharges (HP:0011198)1.59836471
98Fair hair (HP:0002286)1.58584921
99Decreased central vision (HP:0007663)1.56950979
100Amblyopia (HP:0000646)1.56358231

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK13.94170005
2PAK33.11579256
3MARK12.82782611
4TAOK32.63561824
5UHMK12.43070314
6NTRK32.28617502
7BMPR22.19878708
8MAP3K122.10865679
9FRK1.99688021
10PNCK1.98925674
11DMPK1.98920761
12PAK61.98529243
13CDC71.95601804
14MAP3K41.89055527
15PLK21.86455299
16MAP2K71.79636492
17SGK21.73804222
18DAPK21.72619442
19WNK31.67408946
20SGK2231.63770145
21SGK4941.63770145
22NTRK21.62715633
23TEC1.62508169
24CASK1.61499661
25STK391.61407522
26MAP3K91.49619081
27RIPK41.45662779
28CAMK2A1.42588881
29WNK41.38926312
30PRKCG1.38803275
31MINK11.37816114
32TRIM281.36500955
33TNIK1.31407822
34CAMK2B1.24523410
35MAPK131.22477940
36PTK2B1.15080596
37TSSK61.08938820
38MAP2K41.07574172
39CSNK1G21.04219373
40BUB11.02936250
41SGK11.00876990
42NUAK10.99375026
43CAMK10.95357197
44TXK0.94574679
45AKT30.93936098
46CAMK2G0.92141821
47CDK50.92007747
48MAP4K20.90446249
49ADRBK20.89228018
50STK160.87660662
51OXSR10.87267310
52SGK30.86624216
53GRK10.86369917
54CSNK1E0.86153593
55MST40.86142570
56CAMK2D0.85649587
57MAPKAPK30.84506481
58EPHA40.82724288
59PRKCQ0.78888922
60PIK3CA0.78625237
61DAPK10.78328768
62BRD40.77833981
63RPS6KA30.77197684
64CDK140.75964258
65TIE10.74676098
66CSNK1G30.73007831
67INSRR0.72764130
68IRAK20.71213387
69CDK11A0.66962866
70PRKG10.66266227
71CCNB10.64594295
72ERBB30.61852680
73CDK180.61703290
74MAPK150.60921969
75CDK30.60370038
76CDK150.59115737
77CSNK1G10.57901060
78CSNK1A10.57363627
79FES0.57027980
80PRKACA0.56915012
81PRKACB0.54941602
82CSNK1A1L0.54591108
83PRKCH0.52987772
84SYK0.52523019
85PLK40.52512760
86TNK20.51045857
87GRK50.49616756
88PRKCA0.48132022
89MAPK100.47262761
90BMPR1B0.46940777
91PHKG10.41498682
92PHKG20.41498682
93CSNK1D0.41243652
94PRKCE0.38768337
95KIT0.38744508
96DYRK1A0.36817885
97GSK3B0.36452405
98CSNK2A20.35493933
99PRKCZ0.35229410
100MAPK140.35182033

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.98294985
2Amphetamine addiction_Homo sapiens_hsa050312.58689142
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.47374849
4Synaptic vesicle cycle_Homo sapiens_hsa047212.41092370
5Long-term potentiation_Homo sapiens_hsa047202.36937576
6Morphine addiction_Homo sapiens_hsa050322.36381109
7GABAergic synapse_Homo sapiens_hsa047272.33302378
8Dopaminergic synapse_Homo sapiens_hsa047282.31929843
9Circadian entrainment_Homo sapiens_hsa047132.31544424
10Oxidative phosphorylation_Homo sapiens_hsa001902.16715233
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.12746547
12Glutamatergic synapse_Homo sapiens_hsa047242.06136717
13Phototransduction_Homo sapiens_hsa047442.03559885
14Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.03272960
15Insulin secretion_Homo sapiens_hsa049112.02100682
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.00267195
17Salivary secretion_Homo sapiens_hsa049701.96848945
18Collecting duct acid secretion_Homo sapiens_hsa049661.93520704
19Renin secretion_Homo sapiens_hsa049241.93388130
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.86726560
21Taste transduction_Homo sapiens_hsa047421.85635898
22Protein export_Homo sapiens_hsa030601.68732362
23Cocaine addiction_Homo sapiens_hsa050301.65131548
24Caffeine metabolism_Homo sapiens_hsa002321.54693748
25Calcium signaling pathway_Homo sapiens_hsa040201.50620962
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43664202
27Serotonergic synapse_Homo sapiens_hsa047261.43098205
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.41772093
29Olfactory transduction_Homo sapiens_hsa047401.36533856
30Alzheimers disease_Homo sapiens_hsa050101.35900759
31Oxytocin signaling pathway_Homo sapiens_hsa049211.35715128
32Cholinergic synapse_Homo sapiens_hsa047251.32969318
33Gastric acid secretion_Homo sapiens_hsa049711.28067620
34Parkinsons disease_Homo sapiens_hsa050121.26803367
35Asthma_Homo sapiens_hsa053101.23991026
36Folate biosynthesis_Homo sapiens_hsa007901.21088677
37Homologous recombination_Homo sapiens_hsa034401.20810588
38Cardiac muscle contraction_Homo sapiens_hsa042601.15345273
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15195611
40cAMP signaling pathway_Homo sapiens_hsa040241.07495532
41Type I diabetes mellitus_Homo sapiens_hsa049401.05003735
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02772044
43Rheumatoid arthritis_Homo sapiens_hsa053230.99868836
44Mineral absorption_Homo sapiens_hsa049780.98146099
45Pancreatic secretion_Homo sapiens_hsa049720.91360730
46Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89264679
47Graft-versus-host disease_Homo sapiens_hsa053320.86879614
48Oocyte meiosis_Homo sapiens_hsa041140.83985223
49Regulation of autophagy_Homo sapiens_hsa041400.81618614
50Long-term depression_Homo sapiens_hsa047300.81591957
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81504879
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.81009882
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78472419
54Basal transcription factors_Homo sapiens_hsa030220.77697823
55African trypanosomiasis_Homo sapiens_hsa051430.75981854
56Autoimmune thyroid disease_Homo sapiens_hsa053200.72383073
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71201237
58Histidine metabolism_Homo sapiens_hsa003400.69466807
59Allograft rejection_Homo sapiens_hsa053300.68816522
60Linoleic acid metabolism_Homo sapiens_hsa005910.63178345
61Ras signaling pathway_Homo sapiens_hsa040140.63108126
62MAPK signaling pathway_Homo sapiens_hsa040100.62863763
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62427062
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61457379
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59810344
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59067791
67Huntingtons disease_Homo sapiens_hsa050160.58710457
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.55014004
69Sulfur relay system_Homo sapiens_hsa041220.54167736
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.53796089
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53731979
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51374711
73Estrogen signaling pathway_Homo sapiens_hsa049150.45199135
74GnRH signaling pathway_Homo sapiens_hsa049120.45121489
75Prolactin signaling pathway_Homo sapiens_hsa049170.43993340
76Nitrogen metabolism_Homo sapiens_hsa009100.43513256
77Tryptophan metabolism_Homo sapiens_hsa003800.43489385
78RNA degradation_Homo sapiens_hsa030180.42781980
79Dorso-ventral axis formation_Homo sapiens_hsa043200.42033820
80Hematopoietic cell lineage_Homo sapiens_hsa046400.41149322
81Butanoate metabolism_Homo sapiens_hsa006500.39982778
82RNA polymerase_Homo sapiens_hsa030200.39583344
83Salmonella infection_Homo sapiens_hsa051320.38671977
84Circadian rhythm_Homo sapiens_hsa047100.37760367
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36171781
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.35353308
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34944296
88Tyrosine metabolism_Homo sapiens_hsa003500.33800404
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31507053
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29753084
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27878362
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27412588
93T cell receptor signaling pathway_Homo sapiens_hsa046600.25184552
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.24385515
95beta-Alanine metabolism_Homo sapiens_hsa004100.24188930
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23927462
97Rap1 signaling pathway_Homo sapiens_hsa040150.23240840
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.21124665
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.20243985
100Gap junction_Homo sapiens_hsa045400.19510483

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