CALM2P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.83883932
2transcription elongation from RNA polymerase III promoter (GO:0006385)4.46091899
3termination of RNA polymerase III transcription (GO:0006386)4.46091899
4proteasome assembly (GO:0043248)4.37636973
5protein complex biogenesis (GO:0070271)4.29731398
6protein localization to cilium (GO:0061512)4.04115232
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.98961966
8mitochondrial respiratory chain complex assembly (GO:0033108)3.93507241
9nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.93076372
10RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.88931178
11tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.88931178
12regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.85133034
13exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.83372416
14establishment of protein localization to mitochondrial membrane (GO:0090151)3.83016077
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.81970828
16energy coupled proton transport, down electrochemical gradient (GO:0015985)3.81377371
17ATP synthesis coupled proton transport (GO:0015986)3.81377371
18positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.80533859
19NADH dehydrogenase complex assembly (GO:0010257)3.57030982
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.57030982
21mitochondrial respiratory chain complex I assembly (GO:0032981)3.57030982
22respiratory chain complex IV assembly (GO:0008535)3.51715315
23maturation of 5.8S rRNA (GO:0000460)3.45227567
24indole-containing compound catabolic process (GO:0042436)3.42950170
25indolalkylamine catabolic process (GO:0046218)3.42950170
26tryptophan catabolic process (GO:0006569)3.42950170
27kynurenine metabolic process (GO:0070189)3.31124044
28cytochrome complex assembly (GO:0017004)3.30695697
29protein neddylation (GO:0045116)3.25627660
30regulation of immunoglobulin secretion (GO:0051023)3.23616007
31lactate metabolic process (GO:0006089)3.19506907
32gamma-aminobutyric acid transport (GO:0015812)3.18521973
33preassembly of GPI anchor in ER membrane (GO:0016254)3.13737086
34electron transport chain (GO:0022900)3.08678509
35respiratory electron transport chain (GO:0022904)3.08206518
36DNA double-strand break processing (GO:0000729)3.06254887
37regulation of cellular amino acid metabolic process (GO:0006521)3.05328504
38tRNA processing (GO:0008033)3.04356442
39water-soluble vitamin biosynthetic process (GO:0042364)3.00614794
40regulation of regulatory T cell differentiation (GO:0045589)3.00256306
41peptidyl-histidine modification (GO:0018202)2.99427851
42DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.98550576
43RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.98033114
44anterograde synaptic vesicle transport (GO:0048490)2.97885016
45L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.96165229
46chaperone-mediated protein transport (GO:0072321)2.92876503
47aggressive behavior (GO:0002118)2.90449622
48signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.89615794
49signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.89615794
50signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.89615794
51response to pheromone (GO:0019236)2.88242684
52intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.85181783
53signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.85181783
54negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.82720939
55behavioral response to nicotine (GO:0035095)2.80492249
56positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.77475841
57mannosylation (GO:0097502)2.77212931
58L-methionine salvage (GO:0071267)2.75593564
59L-methionine biosynthetic process (GO:0071265)2.75593564
60amino acid salvage (GO:0043102)2.75593564
61intracellular protein transmembrane import (GO:0044743)2.75412458
62aldehyde catabolic process (GO:0046185)2.74465401
63regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.73619408
64signal transduction involved in cell cycle checkpoint (GO:0072395)2.72792785
65signal transduction involved in DNA damage checkpoint (GO:0072422)2.72058696
66signal transduction involved in DNA integrity checkpoint (GO:0072401)2.72058696
67anterograde axon cargo transport (GO:0008089)2.71145181
68regulation of cellular respiration (GO:0043457)2.71070847
69platelet dense granule organization (GO:0060155)2.71037531
70cellular biogenic amine catabolic process (GO:0042402)2.70690970
71amine catabolic process (GO:0009310)2.70690970
72parental behavior (GO:0060746)2.67672557
73kidney morphogenesis (GO:0060993)2.67605508
74ribosomal large subunit biogenesis (GO:0042273)2.67026207
75tryptophan metabolic process (GO:0006568)2.65740120
76indolalkylamine metabolic process (GO:0006586)2.65116814
77hydrogen ion transmembrane transport (GO:1902600)2.64795410
78proton transport (GO:0015992)2.62923444
79rRNA modification (GO:0000154)2.61676729
80regulation of mitochondrial translation (GO:0070129)2.61126354
81regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.61060560
82hydrogen transport (GO:0006818)2.60910141
83DNA damage response, detection of DNA damage (GO:0042769)2.60693385
84transcription elongation from RNA polymerase I promoter (GO:0006362)2.57940856
85GPI anchor metabolic process (GO:0006505)2.57832859
86adenosine metabolic process (GO:0046085)2.56314587
87regulation of action potential (GO:0098900)2.55157308
88base-excision repair, AP site formation (GO:0006285)2.54815492
89negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.53751587
90negative regulation of ligase activity (GO:0051352)2.53751587
91dopamine transport (GO:0015872)2.53260620
92regulation of penile erection (GO:0060405)2.52092915
93signal peptide processing (GO:0006465)2.51826758
94rRNA catabolic process (GO:0016075)2.51254878
95tRNA metabolic process (GO:0006399)2.50884529
96organelle disassembly (GO:1903008)2.49261729
97protein targeting to mitochondrion (GO:0006626)2.47376324
98somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.47143825
99isotype switching (GO:0045190)2.47143825
100somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.47143825

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.39838813
2VDR_22108803_ChIP-Seq_LS180_Human3.39807336
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.28371367
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.17869179
5ZNF274_21170338_ChIP-Seq_K562_Hela2.90946898
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.79028396
7TAF15_26573619_Chip-Seq_HEK293_Human2.57624841
8IGF1R_20145208_ChIP-Seq_DFB_Human2.55656701
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.52183850
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.50460917
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42612150
12GBX2_23144817_ChIP-Seq_PC3_Human2.36101491
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26441470
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23667244
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12920566
16EWS_26573619_Chip-Seq_HEK293_Human2.10996224
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.02896010
18ELK1_19687146_ChIP-ChIP_HELA_Human1.97772244
19VDR_23849224_ChIP-Seq_CD4+_Human1.96978103
20P300_19829295_ChIP-Seq_ESCs_Human1.96728790
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.95493940
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87699111
23FUS_26573619_Chip-Seq_HEK293_Human1.82714278
24EZH2_22144423_ChIP-Seq_EOC_Human1.80401045
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75765606
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.74718924
27PADI4_21655091_ChIP-ChIP_MCF-7_Human1.71931126
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67420185
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64133275
30MYC_18940864_ChIP-ChIP_HL60_Human1.63872865
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63419838
32ER_23166858_ChIP-Seq_MCF-7_Human1.62833077
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58838542
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.53578403
35FOXP3_21729870_ChIP-Seq_TREG_Human1.53145149
36TP53_22573176_ChIP-Seq_HFKS_Human1.51281887
37FOXA1_27270436_Chip-Seq_PROSTATE_Human1.49864054
38FOXA1_25329375_ChIP-Seq_VCAP_Human1.49864054
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.47802733
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46821709
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.46306820
42GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.43951020
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.43174824
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42409405
45BCAT_22108803_ChIP-Seq_LS180_Human1.39637501
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39480796
47AUTS2_25519132_ChIP-Seq_293T-REX_Human1.38828355
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38656877
49KLF5_20875108_ChIP-Seq_MESCs_Mouse1.38580807
50SOX2_19829295_ChIP-Seq_ESCs_Human1.38359483
51NANOG_19829295_ChIP-Seq_ESCs_Human1.38359483
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37408593
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.37283496
54HTT_18923047_ChIP-ChIP_STHdh_Human1.37150243
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36477648
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31303768
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.30786189
58FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.30484546
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30377299
60TCF4_22108803_ChIP-Seq_LS180_Human1.29844563
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28942703
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.27673454
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24931170
64CDX2_22108803_ChIP-Seq_LS180_Human1.24727752
65FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24576567
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22817416
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22019508
68CBP_20019798_ChIP-Seq_JUKART_Human1.21435497
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21435497
70RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18902484
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17889669
72AR_20517297_ChIP-Seq_VCAP_Human1.16261135
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16204051
74CRX_20693478_ChIP-Seq_RETINA_Mouse1.14833543
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14504074
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10677686
77AR_25329375_ChIP-Seq_VCAP_Human1.10288252
78SMAD4_21799915_ChIP-Seq_A2780_Human1.09783080
79NCOR_22424771_ChIP-Seq_293T_Human1.08582273
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.08471308
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06754463
82PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.05054138
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.04850431
84IRF1_19129219_ChIP-ChIP_H3396_Human1.04592592
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04383056
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03266965
87JUN_21703547_ChIP-Seq_K562_Human1.01922902
88TCF4_23295773_ChIP-Seq_U87_Human1.00894261
89CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00033741
90FOXH1_21741376_ChIP-Seq_EPCs_Human0.99601091
91ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98537189
92TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98031959
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97409947
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97345515
95P53_22387025_ChIP-Seq_ESCs_Mouse0.97310579
96SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97098609
97STAT3_23295773_ChIP-Seq_U87_Human0.96237541
98EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95270361
99DCP1A_22483619_ChIP-Seq_HELA_Human0.95191749
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95165274

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.23206266
2MP0002837_dystrophic_cardiac_calcinosis2.90596580
3MP0001835_abnormal_antigen_presentation2.64481603
4MP0001529_abnormal_vocalization2.59607414
5MP0001188_hyperpigmentation2.51200460
6MP0004147_increased_porphyrin_level2.46893863
7MP0008872_abnormal_physiological_respon2.46648603
8MP0001984_abnormal_olfaction2.42903310
9MP0004142_abnormal_muscle_tone2.30969414
10MP0003011_delayed_dark_adaptation2.27337769
11MP0005645_abnormal_hypothalamus_physiol2.26596840
12MP0006072_abnormal_retinal_apoptosis2.22922592
13MP0005084_abnormal_gallbladder_morpholo2.18962502
14MP0009046_muscle_twitch2.18696727
15MP0003806_abnormal_nucleotide_metabolis2.07848943
16MP0001968_abnormal_touch/_nociception2.07785317
17MP0002272_abnormal_nervous_system2.06004380
18MP0009745_abnormal_behavioral_response1.90288263
19MP0000372_irregular_coat_pigmentation1.85789585
20MP0001501_abnormal_sleep_pattern1.81866269
21MP0006035_abnormal_mitochondrial_morpho1.76716625
22MP0008875_abnormal_xenobiotic_pharmacok1.76254236
23MP0005379_endocrine/exocrine_gland_phen1.75005895
24MP0004145_abnormal_muscle_electrophysio1.70887926
25MP0002138_abnormal_hepatobiliary_system1.64468309
26MP0002751_abnormal_autonomic_nervous1.60372331
27MP0001905_abnormal_dopamine_level1.56100925
28MP0005551_abnormal_eye_electrophysiolog1.51851533
29MP0002736_abnormal_nociception_after1.49545998
30MP0001986_abnormal_taste_sensitivity1.49372910
31MP0003195_calcinosis1.49065447
32MP0003718_maternal_effect1.48486985
33MP0008058_abnormal_DNA_repair1.48431020
34MP0004885_abnormal_endolymph1.43341639
35MP0008877_abnormal_DNA_methylation1.42762266
36MP0003122_maternal_imprinting1.42757198
37MP0005253_abnormal_eye_physiology1.40429358
38MP0003786_premature_aging1.37770463
39MP0006276_abnormal_autonomic_nervous1.35856262
40MP0010386_abnormal_urinary_bladder1.35216789
41MP0003787_abnormal_imprinting1.34342175
42MP0003880_abnormal_central_pattern1.34326878
43MP0002557_abnormal_social/conspecific_i1.33729091
44MP0004924_abnormal_behavior1.31275424
45MP0005386_behavior/neurological_phenoty1.31275424
46MP0002572_abnormal_emotion/affect_behav1.30173715
47MP0001970_abnormal_pain_threshold1.26809102
48MP0003137_abnormal_impulse_conducting1.25516716
49MP0006036_abnormal_mitochondrial_physio1.25142246
50MP0002638_abnormal_pupillary_reflex1.24669785
51MP0000516_abnormal_urinary_system1.24508058
52MP0005367_renal/urinary_system_phenotyp1.24508058
53MP0002909_abnormal_adrenal_gland1.24271142
54MP0000631_abnormal_neuroendocrine_gland1.23991628
55MP0002160_abnormal_reproductive_system1.21930852
56MP0009379_abnormal_foot_pigmentation1.19964842
57MP0001440_abnormal_grooming_behavior1.19592690
58MP0000685_abnormal_immune_system1.18189433
59MP0001502_abnormal_circadian_rhythm1.15434576
60MP0002064_seizures1.15358647
61MP0004019_abnormal_vitamin_homeostasis1.14080570
62MP0005646_abnormal_pituitary_gland1.13377966
63MP0005389_reproductive_system_phenotype1.13314077
64MP0005671_abnormal_response_to1.11962268
65MP0001486_abnormal_startle_reflex1.09554734
66MP0002067_abnormal_sensory_capabilities1.08999699
67MP0003186_abnormal_redox_activity1.08236031
68MP0002938_white_spotting1.07805212
69MP0005174_abnormal_tail_pigmentation1.06947883
70MP0002734_abnormal_mechanical_nocicepti1.06372762
71MP0000569_abnormal_digit_pigmentation1.04536405
72MP0002733_abnormal_thermal_nociception1.03732161
73MP0003635_abnormal_synaptic_transmissio1.03465791
74MP0002735_abnormal_chemical_nociception1.00754102
75MP0006292_abnormal_olfactory_placode1.00437814
76MP0002090_abnormal_vision0.99429843
77MP0005075_abnormal_melanosome_morpholog0.98409765
78MP0002876_abnormal_thyroid_physiology0.94378635
79MP0002234_abnormal_pharynx_morphology0.93519627
80MP0005332_abnormal_amino_acid0.92907366
81MP0004270_analgesia0.91047338
82MP0002184_abnormal_innervation0.90878411
83MP0001485_abnormal_pinna_reflex0.90159027
84MP0002229_neurodegeneration0.89958947
85MP0005636_abnormal_mineral_homeostasis0.89509729
86MP0002254_reproductive_system_inflammat0.89295723
87MP0003121_genomic_imprinting0.89288068
88MP0004085_abnormal_heartbeat0.89099762
89MP0008007_abnormal_cellular_replicative0.87297205
90MP0003567_abnormal_fetal_cardiomyocyte0.87089608
91MP0001756_abnormal_urination0.85358710
92MP0004215_abnormal_myocardial_fiber0.85333151
93MP0005187_abnormal_penis_morphology0.85213608
94MP0000427_abnormal_hair_cycle0.84806019
95MP0002166_altered_tumor_susceptibility0.80559431
96MP0002006_tumorigenesis0.79607185
97MP0000013_abnormal_adipose_tissue0.79360046
98MP0001348_abnormal_lacrimal_gland0.76473821
99MP0005535_abnormal_body_temperature0.75965701
100MP0002139_abnormal_hepatobiliary_system0.75210610

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.83951439
2Abnormal mitochondria in muscle tissue (HP:0008316)4.39839805
3Progressive macrocephaly (HP:0004481)4.38199759
4Acute encephalopathy (HP:0006846)4.24295747
5Type II lissencephaly (HP:0007260)4.02110843
6Mitochondrial inheritance (HP:0001427)3.73826299
7Decreased activity of mitochondrial respiratory chain (HP:0008972)3.72027485
8Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.72027485
9Hepatocellular necrosis (HP:0001404)3.63046792
10Increased CSF lactate (HP:0002490)3.61731933
113-Methylglutaconic aciduria (HP:0003535)3.49046061
12Hepatic necrosis (HP:0002605)3.34233589
13Pancreatic cysts (HP:0001737)3.30830475
14Abnormality of midbrain morphology (HP:0002418)3.15099019
15Molar tooth sign on MRI (HP:0002419)3.15099019
16Nephronophthisis (HP:0000090)2.92798885
17Cerebral edema (HP:0002181)2.82861323
18Abolished electroretinogram (ERG) (HP:0000550)2.79620788
19Methylmalonic acidemia (HP:0002912)2.78571567
20Congenital, generalized hypertrichosis (HP:0004540)2.78390273
21Renal cortical cysts (HP:0000803)2.65002746
22Leukodystrophy (HP:0002415)2.61693957
23Retinal dysplasia (HP:0007973)2.58950834
24Congenital stationary night blindness (HP:0007642)2.54981679
25Optic disc pallor (HP:0000543)2.52053123
26Abnormality of the renal cortex (HP:0011035)2.51914111
27Pancreatic fibrosis (HP:0100732)2.51070077
28Cerebellar dysplasia (HP:0007033)2.50775299
29Decreased electroretinogram (ERG) amplitude (HP:0000654)2.48434860
30Aplasia/hypoplasia of the uterus (HP:0008684)2.44790186
31Respiratory failure (HP:0002878)2.44647252
32Increased hepatocellular lipid droplets (HP:0006565)2.42687765
33True hermaphroditism (HP:0010459)2.39756964
34Lipid accumulation in hepatocytes (HP:0006561)2.34293806
35Abnormality of the renal medulla (HP:0100957)2.33825423
36Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.31608960
37Abnormality of alanine metabolism (HP:0010916)2.31608960
38Hyperalaninemia (HP:0003348)2.31608960
39Delayed CNS myelination (HP:0002188)2.30004713
40Methylmalonic aciduria (HP:0012120)2.25470828
41Lethargy (HP:0001254)2.24129316
42CNS demyelination (HP:0007305)2.24112072
43Increased serum lactate (HP:0002151)2.22967323
44Hypoproteinemia (HP:0003075)2.21637495
45Bile duct proliferation (HP:0001408)2.20446501
46Abnormal biliary tract physiology (HP:0012439)2.20446501
47IgG deficiency (HP:0004315)2.18714885
48Lactic acidosis (HP:0003128)2.18522068
49Abnormality of the pons (HP:0007361)2.18235676
50Hypothermia (HP:0002045)2.14298311
51Hyperglycinemia (HP:0002154)2.12164574
52Hypoplasia of the pons (HP:0012110)2.11918788
53Thyroiditis (HP:0100646)2.09887288
54Short tibia (HP:0005736)2.04746644
55Abnormality of serum amino acid levels (HP:0003112)2.04098484
56Increased corneal curvature (HP:0100692)2.03207417
57Keratoconus (HP:0000563)2.03207417
58Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00135516
59Lissencephaly (HP:0001339)1.99358920
60Hyperventilation (HP:0002883)1.96731293
61Multiple enchondromatosis (HP:0005701)1.93699253
62Stomatitis (HP:0010280)1.92825864
63Delayed gross motor development (HP:0002194)1.90470337
64Aplasia/Hypoplasia of the tibia (HP:0005772)1.89244621
65Abnormality of the anterior horn cell (HP:0006802)1.89070506
66Degeneration of anterior horn cells (HP:0002398)1.89070506
67Abnormality of vitamin B metabolism (HP:0004340)1.87186117
68Progressive inability to walk (HP:0002505)1.86504217
69Renal Fanconi syndrome (HP:0001994)1.84703609
70Focal motor seizures (HP:0011153)1.84182794
71Atonic seizures (HP:0010819)1.83268440
72Hypoplasia of the uterus (HP:0000013)1.81811476
73Cerebral hypomyelination (HP:0006808)1.81795854
74Limb dystonia (HP:0002451)1.81579719
75Sclerocornea (HP:0000647)1.80994374
76Dialeptic seizures (HP:0011146)1.80900234
77Brushfield spots (HP:0001088)1.79037989
78Abnormal rod and cone electroretinograms (HP:0008323)1.78149520
79Increased intramyocellular lipid droplets (HP:0012240)1.77515686
80Fibular aplasia (HP:0002990)1.76408468
81Neoplasm of the adrenal cortex (HP:0100641)1.75485880
82Febrile seizures (HP:0002373)1.75456564
83Abnormality of urine glucose concentration (HP:0011016)1.75172612
84Glycosuria (HP:0003076)1.75172612
85Symphalangism affecting the phalanges of the hand (HP:0009773)1.70117434
86Abnormality of the vitamin B12 metabolism (HP:0004341)1.69123475
87Type I transferrin isoform profile (HP:0003642)1.68916243
88Cleft eyelid (HP:0000625)1.68312240
89Blindness (HP:0000618)1.67328681
90Pendular nystagmus (HP:0012043)1.67170551
91Medial flaring of the eyebrow (HP:0010747)1.64698986
92Abnormality of the proximal phalanges of the hand (HP:0009834)1.64208216
93Abnormality of the labia minora (HP:0012880)1.63278020
94Absence seizures (HP:0002121)1.61714843
95Median cleft lip (HP:0000161)1.61584664
96Agitation (HP:0000713)1.61247101
97Intestinal atresia (HP:0011100)1.61111167
98Short 1st metacarpal (HP:0010034)1.60605637
99Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.60605637
100Progressive microcephaly (HP:0000253)1.60096917

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.70490294
2MAP4K23.42172875
3TRIM283.13434817
4EIF2AK12.65513618
5PINK12.41680979
6ZAK2.39328545
7EIF2AK32.35945697
8MST42.34705640
9ADRBK22.34596504
10STK162.33420461
11CSNK1G32.23693592
12BMPR1B2.19141325
13WNK32.06998075
14CSNK1G22.06044038
15CSNK1G12.05355585
16CSNK1A1L1.98391246
17MAPKAPK31.96473470
18TSSK61.95432914
19NEK11.85920916
20GRK11.80657964
21TNIK1.64746941
22NUAK11.58618013
23PHKG21.56748912
24PHKG11.56748912
25MAPK131.51633010
26MAP3K121.47976427
27TLK11.47711476
28SRPK11.44270253
29PLK31.39007351
30MKNK21.24250274
31MAP3K41.22243133
32OXSR11.21326212
33PLK21.19001290
34DYRK21.18921740
35ERBB31.17886484
36TAOK31.17068350
37INSRR1.15883174
38BCR1.14629209
39PRKCE1.11674629
40VRK21.06665590
41MYLK1.04366865
42AKT31.01548525
43VRK11.01168063
44CASK0.99288204
45FLT30.98758386
46MINK10.92929410
47WNK40.90930613
48MARK10.90176738
49GRK70.84165002
50MAP3K130.78059054
51EIF2AK20.78051018
52PRKCG0.77498521
53BUB10.77484292
54PAK30.73973205
55BMPR20.73887067
56STK390.73002453
57GRK50.70141049
58CAMK2A0.68738963
59ATR0.65962127
60TEC0.64207212
61MAP2K70.64004181
62CSNK1A10.61484738
63KIT0.60046055
64NME10.57217009
65DAPK10.54404477
66ADRBK10.54305056
67FES0.54203665
68MKNK10.53953061
69EPHA30.53661262
70FGFR20.52768527
71CSNK2A10.52154415
72RPS6KA50.51136823
73SCYL20.50866487
74FER0.50634008
75PLK10.48844889
76CSNK1E0.46901345
77IKBKB0.46771378
78WEE10.46020476
79EGFR0.45706798
80NTRK30.45135882
81PRKACA0.43449134
82TXK0.41960573
83CSNK1D0.41654077
84CAMK2D0.40062991
85OBSCN0.39876847
86CSNK2A20.38522641
87TIE10.37177515
88MAP3K140.36724927
89PLK40.36183388
90LIMK10.36007487
91PRKG10.35700009
92PRKCA0.35247177
93ACVR1B0.33623493
94CDC70.32600057
95ATM0.32407076
96DAPK30.32300563
97PRKCB0.32168049
98LYN0.31956732
99CAMK2B0.30933600
100ALK0.30776480

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.76182350
2Proteasome_Homo sapiens_hsa030503.36553913
3Asthma_Homo sapiens_hsa053103.30896141
4Oxidative phosphorylation_Homo sapiens_hsa001903.26724418
5RNA polymerase_Homo sapiens_hsa030202.67866235
6Type I diabetes mellitus_Homo sapiens_hsa049402.60966572
7Allograft rejection_Homo sapiens_hsa053302.59402956
8Parkinsons disease_Homo sapiens_hsa050122.58126485
9Autoimmune thyroid disease_Homo sapiens_hsa053202.48220733
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.35375210
11Graft-versus-host disease_Homo sapiens_hsa053322.09636674
12Phototransduction_Homo sapiens_hsa047442.07190578
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.88720341
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86290514
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.71534304
16Alzheimers disease_Homo sapiens_hsa050101.70195661
17Collecting duct acid secretion_Homo sapiens_hsa049661.59946805
18Huntingtons disease_Homo sapiens_hsa050161.53205761
19RNA degradation_Homo sapiens_hsa030181.41217075
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40966278
21Rheumatoid arthritis_Homo sapiens_hsa053231.37379615
22Homologous recombination_Homo sapiens_hsa034401.35837870
23Nitrogen metabolism_Homo sapiens_hsa009101.28850241
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25295447
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25173053
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22697002
27Tryptophan metabolism_Homo sapiens_hsa003801.21183343
28Linoleic acid metabolism_Homo sapiens_hsa005911.20811649
29Cardiac muscle contraction_Homo sapiens_hsa042601.19256871
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18342629
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16068778
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.15991985
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13785208
34Regulation of autophagy_Homo sapiens_hsa041401.13565434
35Butanoate metabolism_Homo sapiens_hsa006501.12681146
36Nicotine addiction_Homo sapiens_hsa050331.10575140
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09737143
38Basal transcription factors_Homo sapiens_hsa030221.06533980
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05878544
40Peroxisome_Homo sapiens_hsa041461.02227323
41Propanoate metabolism_Homo sapiens_hsa006401.02138554
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02043968
43Ether lipid metabolism_Homo sapiens_hsa005650.99516369
44Pyrimidine metabolism_Homo sapiens_hsa002400.95435265
45GABAergic synapse_Homo sapiens_hsa047270.94361124
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93875249
47Mismatch repair_Homo sapiens_hsa034300.93203006
48RNA transport_Homo sapiens_hsa030130.89566267
49Caffeine metabolism_Homo sapiens_hsa002320.86059416
50Purine metabolism_Homo sapiens_hsa002300.85133266
51Nucleotide excision repair_Homo sapiens_hsa034200.84862390
52Morphine addiction_Homo sapiens_hsa050320.84505871
53Circadian entrainment_Homo sapiens_hsa047130.80530348
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80453815
55Non-homologous end-joining_Homo sapiens_hsa034500.79496634
56Sulfur metabolism_Homo sapiens_hsa009200.77680000
57Olfactory transduction_Homo sapiens_hsa047400.76567664
58Antigen processing and presentation_Homo sapiens_hsa046120.76232020
59Viral myocarditis_Homo sapiens_hsa054160.76048193
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.76032781
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75046055
62Chemical carcinogenesis_Homo sapiens_hsa052040.74336275
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73939381
64Fat digestion and absorption_Homo sapiens_hsa049750.72264381
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71448432
66One carbon pool by folate_Homo sapiens_hsa006700.70860945
67Base excision repair_Homo sapiens_hsa034100.69270648
68Retinol metabolism_Homo sapiens_hsa008300.69000878
69Fanconi anemia pathway_Homo sapiens_hsa034600.68685161
70Systemic lupus erythematosus_Homo sapiens_hsa053220.66236084
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65845047
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65042311
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64888954
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64460219
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63902396
76Dopaminergic synapse_Homo sapiens_hsa047280.62444637
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60081949
78Synaptic vesicle cycle_Homo sapiens_hsa047210.58180862
79Glutamatergic synapse_Homo sapiens_hsa047240.56937943
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.56250234
81Arachidonic acid metabolism_Homo sapiens_hsa005900.56229620
82Metabolic pathways_Homo sapiens_hsa011000.53859072
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52843640
84Serotonergic synapse_Homo sapiens_hsa047260.49312646
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.48082520
86Selenocompound metabolism_Homo sapiens_hsa004500.48023880
87Fatty acid elongation_Homo sapiens_hsa000620.47944714
88Folate biosynthesis_Homo sapiens_hsa007900.47539686
89Renin secretion_Homo sapiens_hsa049240.46698239
90Salivary secretion_Homo sapiens_hsa049700.46391652
91Taste transduction_Homo sapiens_hsa047420.45869262
92Pyruvate metabolism_Homo sapiens_hsa006200.44777581
93Oocyte meiosis_Homo sapiens_hsa041140.41639354
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40749574
95Ribosome_Homo sapiens_hsa030100.40244245
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.38434740
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37984770
98Amphetamine addiction_Homo sapiens_hsa050310.37331639
99Circadian rhythm_Homo sapiens_hsa047100.36456529
100Insulin secretion_Homo sapiens_hsa049110.36025023

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