CALM2P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)7.28443459
2cytochrome complex assembly (GO:0017004)5.54109670
3respiratory chain complex IV assembly (GO:0008535)5.25566062
4indolalkylamine catabolic process (GO:0046218)5.24394204
5tryptophan catabolic process (GO:0006569)5.24394204
6indole-containing compound catabolic process (GO:0042436)5.24394204
7kynurenine metabolic process (GO:0070189)4.93265045
8DNA catabolic process, exonucleolytic (GO:0000738)4.73080274
9maturation of 5.8S rRNA (GO:0000460)4.69578949
10mitochondrial DNA replication (GO:0006264)4.40285992
11protein complex biogenesis (GO:0070271)4.37162119
12tryptophan metabolic process (GO:0006568)4.29272875
13DNA deamination (GO:0045006)4.25494005
14mitochondrial respiratory chain complex assembly (GO:0033108)4.01295605
15water-soluble vitamin biosynthetic process (GO:0042364)3.96941243
16behavioral response to nicotine (GO:0035095)3.95351159
17dopamine transport (GO:0015872)3.89529632
18aromatic amino acid family catabolic process (GO:0009074)3.85077093
19ATP synthesis coupled proton transport (GO:0015986)3.79518606
20energy coupled proton transport, down electrochemical gradient (GO:0015985)3.79518606
21nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.79111510
22indolalkylamine metabolic process (GO:0006586)3.77284606
23heart contraction (GO:0060047)3.75717925
24heart process (GO:0003015)3.75717925
25DNA replication checkpoint (GO:0000076)3.72419431
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.66543236
27L-fucose catabolic process (GO:0042355)3.60665202
28fucose catabolic process (GO:0019317)3.60665202
29L-fucose metabolic process (GO:0042354)3.60665202
30amine catabolic process (GO:0009310)3.56619870
31cellular biogenic amine catabolic process (GO:0042402)3.56619870
32RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.53048339
33mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.48943003
34exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.46162490
35proteasome assembly (GO:0043248)3.45625257
36establishment of protein localization to mitochondrial membrane (GO:0090151)3.44583035
37neuronal action potential propagation (GO:0019227)3.37912819
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.32489401
39mitochondrial respiratory chain complex I assembly (GO:0032981)3.32489401
40NADH dehydrogenase complex assembly (GO:0010257)3.32489401
41negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.27307578
42RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.24719209
43tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.24719209
44autophagic vacuole fusion (GO:0000046)3.24509600
45GMP metabolic process (GO:0046037)3.23329281
46chaperone-mediated protein transport (GO:0072321)3.18633983
47piRNA metabolic process (GO:0034587)3.14279332
48DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.11918819
49regulation of mitochondrial translation (GO:0070129)3.11153533
50inositol phosphate catabolic process (GO:0071545)3.08689122
51phosphorylated carbohydrate dephosphorylation (GO:0046838)3.05465489
52inositol phosphate dephosphorylation (GO:0046855)3.05465489
53signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.02924917
54signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.02924917
55signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.02924917
56electron transport chain (GO:0022900)3.02025209
57signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.00339783
58intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.00339783
59respiratory electron transport chain (GO:0022904)2.99705238
60replication fork processing (GO:0031297)2.97912050
61regulation of glucokinase activity (GO:0033131)2.97574406
62regulation of hexokinase activity (GO:1903299)2.97574406
63regulation of cellular amino acid metabolic process (GO:0006521)2.96979744
64postreplication repair (GO:0006301)2.96252849
65response to misfolded protein (GO:0051788)2.93601283
66NAD biosynthetic process (GO:0009435)2.85050556
67signal transduction involved in cell cycle checkpoint (GO:0072395)2.83530051
68signal transduction involved in DNA integrity checkpoint (GO:0072401)2.81913165
69signal transduction involved in DNA damage checkpoint (GO:0072422)2.81913165
70oxidative phosphorylation (GO:0006119)2.81318343
71protein K6-linked ubiquitination (GO:0085020)2.78919954
72negative regulation of telomere maintenance (GO:0032205)2.78645246
73adenosine metabolic process (GO:0046085)2.77192780
74purine nucleotide salvage (GO:0032261)2.76874835
75negative regulation of T cell differentiation in thymus (GO:0033085)2.73524022
76nucleotide transmembrane transport (GO:1901679)2.72033338
77transcription elongation from RNA polymerase III promoter (GO:0006385)2.71389191
78termination of RNA polymerase III transcription (GO:0006386)2.71389191
79regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.70642662
80aromatic amino acid family metabolic process (GO:0009072)2.70055394
81negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.66711407
82DNA-dependent DNA replication (GO:0006261)2.66628872
83pseudouridine synthesis (GO:0001522)2.65405094
84indole-containing compound metabolic process (GO:0042430)2.65335370
85transcription from mitochondrial promoter (GO:0006390)2.64697750
86organelle membrane fusion (GO:0090174)2.63640993
87protein neddylation (GO:0045116)2.61131099
88branched-chain amino acid catabolic process (GO:0009083)2.60594670
89positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.60559606
90hydrogen ion transmembrane transport (GO:1902600)2.60275224
91transcription elongation from RNA polymerase I promoter (GO:0006362)2.59222329
92response to interferon-beta (GO:0035456)2.58014896
93termination of RNA polymerase I transcription (GO:0006363)2.57098721
94proton transport (GO:0015992)2.56968536
95hydrogen transport (GO:0006818)2.56740080
96cellular response to interferon-beta (GO:0035458)2.56272212
97peptidyl-histidine modification (GO:0018202)2.55894532
98negative regulation of ligase activity (GO:0051352)2.52363753
99negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.52363753
100protein deneddylation (GO:0000338)2.51465042

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.83682409
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.32174386
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.22001127
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.10745485
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.63919432
6ZNF274_21170338_ChIP-Seq_K562_Hela2.61340019
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.46079875
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.43278598
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.36867046
10ELK1_19687146_ChIP-ChIP_HELA_Human2.28328258
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.17178553
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13942193
13EWS_26573619_Chip-Seq_HEK293_Human2.13200730
14VDR_23849224_ChIP-Seq_CD4+_Human2.12665396
15TAF15_26573619_Chip-Seq_HEK293_Human2.10876105
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07676619
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.06143561
18FUS_26573619_Chip-Seq_HEK293_Human2.05111315
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.00054752
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97358678
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89134180
22ER_23166858_ChIP-Seq_MCF-7_Human1.84819183
23IRF8_22096565_ChIP-ChIP_GC-B_Human1.84195796
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82568764
25BP1_19119308_ChIP-ChIP_Hs578T_Human1.79290569
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.75416254
27P300_19829295_ChIP-Seq_ESCs_Human1.68377527
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.66533727
29GBX2_23144817_ChIP-Seq_PC3_Human1.66403158
30IGF1R_20145208_ChIP-Seq_DFB_Human1.62983058
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61509227
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.59549130
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59371602
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58297788
35FOXP3_21729870_ChIP-Seq_TREG_Human1.58102084
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55778961
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.55074003
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51952077
39NANOG_19829295_ChIP-Seq_ESCs_Human1.51720889
40SOX2_19829295_ChIP-Seq_ESCs_Human1.51720889
41NFE2_27457419_Chip-Seq_LIVER_Mouse1.47200684
42EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.46365867
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.43817757
44AR_20517297_ChIP-Seq_VCAP_Human1.43587746
45FOXA1_21572438_ChIP-Seq_LNCaP_Human1.43148974
46BCAT_22108803_ChIP-Seq_LS180_Human1.42966425
47TP53_22573176_ChIP-Seq_HFKS_Human1.42441781
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41932807
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.41932807
50ETV2_25802403_ChIP-Seq_MESCs_Mouse1.38042997
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.38015358
52MYC_18940864_ChIP-ChIP_HL60_Human1.37479253
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37354116
54KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36764120
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36262337
56IRF1_19129219_ChIP-ChIP_H3396_Human1.35871171
57RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.32497386
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32415715
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30328342
60TCF4_22108803_ChIP-Seq_LS180_Human1.26422681
61CBP_20019798_ChIP-Seq_JUKART_Human1.25986154
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25986154
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25967608
64NCOR_22424771_ChIP-Seq_293T_Human1.24604012
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.23768558
66AUTS2_25519132_ChIP-Seq_293T-REX_Human1.21707164
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21592344
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21107254
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20507234
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18675920
71PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.18474328
72AR_25329375_ChIP-Seq_VCAP_Human1.18209006
73HTT_18923047_ChIP-ChIP_STHdh_Human1.17632734
74CRX_20693478_ChIP-Seq_RETINA_Mouse1.17166621
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16785177
76OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14686512
77CDX2_22108803_ChIP-Seq_LS180_Human1.13068350
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12406559
79SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12208396
80HOXB7_26014856_ChIP-Seq_BT474_Human1.12008817
81GATA3_26560356_Chip-Seq_TH2_Human1.10938992
82DCP1A_22483619_ChIP-Seq_HELA_Human1.10677579
83GABP_19822575_ChIP-Seq_HepG2_Human1.10470563
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09905748
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.08870141
86GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.08706745
87FOXH1_21741376_ChIP-Seq_EPCs_Human1.07264000
88TCF4_23295773_ChIP-Seq_U87_Human1.07180021
89PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04628742
90CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04443637
91CBP_21632823_ChIP-Seq_H3396_Human1.04338250
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04268501
93IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04074006
94SMAD4_21799915_ChIP-Seq_A2780_Human1.02124577
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01994634
96STAT3_18555785_Chip-Seq_ESCs_Mouse1.01954984
97PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01368501
98FLI1_21867929_ChIP-Seq_TH2_Mouse1.01209989
99EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97711302
100ERG_20517297_ChIP-Seq_VCAP_Human0.95402181

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis6.00818168
2MP0002138_abnormal_hepatobiliary_system3.84132522
3MP0000569_abnormal_digit_pigmentation3.83613159
4MP0008875_abnormal_xenobiotic_pharmacok3.43449013
5MP0010386_abnormal_urinary_bladder3.35488019
6MP0003880_abnormal_central_pattern3.14802030
7MP0006072_abnormal_retinal_apoptosis3.00840190
8MP0001968_abnormal_touch/_nociception2.97679584
9MP0001835_abnormal_antigen_presentation2.92787418
10MP0003195_calcinosis2.72951672
11MP0003787_abnormal_imprinting2.51039203
12MP0005645_abnormal_hypothalamus_physiol2.38422918
13MP0008058_abnormal_DNA_repair2.22563727
14MP0008872_abnormal_physiological_respon2.10760065
15MP0006054_spinal_hemorrhage2.09279567
16MP0001529_abnormal_vocalization2.04468126
17MP0002638_abnormal_pupillary_reflex1.99921743
18MP0009697_abnormal_copulation1.79452038
19MP0003186_abnormal_redox_activity1.71990507
20MP0005174_abnormal_tail_pigmentation1.70649587
21MP0005646_abnormal_pituitary_gland1.70462734
22MP0000372_irregular_coat_pigmentation1.69771432
23MP0002272_abnormal_nervous_system1.67906987
24MP0009046_muscle_twitch1.66826389
25MP0004145_abnormal_muscle_electrophysio1.65052690
26MP0003950_abnormal_plasma_membrane1.64111100
27MP0002837_dystrophic_cardiac_calcinosis1.59756762
28MP0005075_abnormal_melanosome_morpholog1.59736021
29MP0002736_abnormal_nociception_after1.58135938
30MP0005408_hypopigmentation1.56166979
31MP0006036_abnormal_mitochondrial_physio1.54008105
32MP0003786_premature_aging1.50684322
33MP0000015_abnormal_ear_pigmentation1.49509712
34MP0002751_abnormal_autonomic_nervous1.47887328
35MP0006035_abnormal_mitochondrial_morpho1.39528707
36MP0001905_abnormal_dopamine_level1.37274056
37MP0006292_abnormal_olfactory_placode1.36716335
38MP0008877_abnormal_DNA_methylation1.36532567
39MP0000427_abnormal_hair_cycle1.36478969
40MP0009745_abnormal_behavioral_response1.32319526
41MP0002095_abnormal_skin_pigmentation1.28841236
42MP0000538_abnormal_urinary_bladder1.28119600
43MP0005253_abnormal_eye_physiology1.25887230
44MP0001984_abnormal_olfaction1.23032184
45MP0006276_abnormal_autonomic_nervous1.22133830
46MP0000631_abnormal_neuroendocrine_gland1.20477319
47MP0004215_abnormal_myocardial_fiber1.15866114
48MP0005551_abnormal_eye_electrophysiolog1.15187768
49MP0005671_abnormal_response_to1.09097839
50MP0001970_abnormal_pain_threshold1.08747717
51MP0005220_abnormal_exocrine_pancreas1.07448784
52MP0002102_abnormal_ear_morphology1.06295321
53MP0004142_abnormal_muscle_tone1.06059704
54MP0005389_reproductive_system_phenotype1.04642917
55MP0002234_abnormal_pharynx_morphology1.04057276
56MP0002909_abnormal_adrenal_gland1.03737335
57MP0009780_abnormal_chondrocyte_physiolo1.02157212
58MP0005636_abnormal_mineral_homeostasis1.00776997
59MP0003137_abnormal_impulse_conducting0.98388155
60MP0003252_abnormal_bile_duct0.94899583
61MP0009785_altered_susceptibility_to0.94395917
62MP0002166_altered_tumor_susceptibility0.93740535
63MP0003866_abnormal_defecation0.93187762
64MP0005332_abnormal_amino_acid0.90872285
65MP0008995_early_reproductive_senescence0.89973218
66MP0002938_white_spotting0.88430343
67MP0002733_abnormal_thermal_nociception0.87359422
68MP0005083_abnormal_biliary_tract0.86494390
69MP0000639_abnormal_adrenal_gland0.85471190
70MP0000613_abnormal_salivary_gland0.84023555
71MP0005410_abnormal_fertilization0.81337825
72MP0001440_abnormal_grooming_behavior0.80901151
73MP0002693_abnormal_pancreas_physiology0.80323814
74MP0000371_diluted_coat_color0.79590889
75MP0002734_abnormal_mechanical_nocicepti0.78639382
76MP0003011_delayed_dark_adaptation0.78508612
77MP0001919_abnormal_reproductive_system0.77311747
78MP0002067_abnormal_sensory_capabilities0.76777044
79MP0005085_abnormal_gallbladder_physiolo0.76582924
80MP0005386_behavior/neurological_phenoty0.76576831
81MP0004924_abnormal_behavior0.76576831
82MP0004484_altered_response_of0.75266687
83MP0002735_abnormal_chemical_nociception0.74738122
84MP0005266_abnormal_metabolism0.74605983
85MP0000358_abnormal_cell_content/0.74493582
86MP0004147_increased_porphyrin_level0.73046733
87MP0002876_abnormal_thyroid_physiology0.73020214
88MP0000013_abnormal_adipose_tissue0.70942552
89MP0002006_tumorigenesis0.70306467
90MP0002572_abnormal_emotion/affect_behav0.70089962
91MP0001765_abnormal_ion_homeostasis0.68787261
92MP0001800_abnormal_humoral_immune0.68247938
93MP0005171_absent_coat_pigmentation0.67723590
94MP0002163_abnormal_gland_morphology0.67593790
95MP0004043_abnormal_pH_regulation0.67515738
96MP0005084_abnormal_gallbladder_morpholo0.67304998
97MP0002160_abnormal_reproductive_system0.65809407
98MP0003121_genomic_imprinting0.65641984
99MP0001756_abnormal_urination0.64887606
100MP0001790_abnormal_immune_system0.60832423

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.47413897
23-Methylglutaconic aciduria (HP:0003535)4.39788195
3Progressive macrocephaly (HP:0004481)4.14989147
4Mitochondrial inheritance (HP:0001427)4.10674358
5Hepatocellular necrosis (HP:0001404)4.09209194
6Abnormal mitochondria in muscle tissue (HP:0008316)3.85186142
7Congenital, generalized hypertrichosis (HP:0004540)3.83906872
8Acute encephalopathy (HP:0006846)3.80474339
9Increased CSF lactate (HP:0002490)3.77372416
10Hepatic necrosis (HP:0002605)3.41496602
11Large for gestational age (HP:0001520)3.32397392
12Methylmalonic acidemia (HP:0002912)3.24514789
13Congenital stationary night blindness (HP:0007642)3.18080203
14Exertional dyspnea (HP:0002875)3.09372715
15Hypothermia (HP:0002045)2.97660378
16Abnormality of aspartate family amino acid metabolism (HP:0010899)2.83299070
17Amelogenesis imperfecta (HP:0000705)2.81566319
18Hypoproteinemia (HP:0003075)2.81218052
19Abnormality of the pancreatic islet cells (HP:0006476)2.78565570
20Abnormality of endocrine pancreas physiology (HP:0012093)2.78565570
21Ketoacidosis (HP:0001993)2.78345587
22Pancreatic islet-cell hyperplasia (HP:0004510)2.77111892
23B lymphocytopenia (HP:0010976)2.74689076
24Pancreatic cysts (HP:0001737)2.73816591
25Abnormality of methionine metabolism (HP:0010901)2.71061101
26Increased serum lactate (HP:0002151)2.69793003
27Hyperventilation (HP:0002883)2.60548922
28Abnormal rod and cone electroretinograms (HP:0008323)2.55243067
29Nephronophthisis (HP:0000090)2.52633076
30Abnormality of B cell number (HP:0010975)2.49323563
31Lactic acidosis (HP:0003128)2.48294589
32Respiratory failure (HP:0002878)2.47597752
33Cerebral edema (HP:0002181)2.43180861
34Renal Fanconi syndrome (HP:0001994)2.42363276
35Fair hair (HP:0002286)2.40256794
36Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.39445614
37Methylmalonic aciduria (HP:0012120)2.38512111
38Atonic seizures (HP:0010819)2.38404811
39Aplastic anemia (HP:0001915)2.36295810
40Slender build (HP:0001533)2.34773996
41Abnormality of vitamin B metabolism (HP:0004340)2.31621888
42Lethargy (HP:0001254)2.29830055
43Optic disc pallor (HP:0000543)2.27413302
44Abnormality of aromatic amino acid family metabolism (HP:0004338)2.26892994
45Hypomagnesemia (HP:0002917)2.26673779
46Abnormality of midbrain morphology (HP:0002418)2.22827647
47Molar tooth sign on MRI (HP:0002419)2.22827647
48Hypophosphatemic rickets (HP:0004912)2.15945258
49Stomatitis (HP:0010280)2.14892746
50Panhypogammaglobulinemia (HP:0003139)2.13533393
51Decreased electroretinogram (ERG) amplitude (HP:0000654)2.13455706
52Increased hepatocellular lipid droplets (HP:0006565)2.12825001
53Abnormality of the vitamin B12 metabolism (HP:0004341)2.11886423
54Thyroiditis (HP:0100646)2.10878285
55True hermaphroditism (HP:0010459)2.09925614
56Testicular atrophy (HP:0000029)2.08926199
57Exercise intolerance (HP:0003546)2.07593503
58Decreased activity of mitochondrial respiratory chain (HP:0008972)2.06846367
59Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.06846367
60Hyperalaninemia (HP:0003348)2.04585649
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04585649
62Abnormality of alanine metabolism (HP:0010916)2.04585649
63Woolly hair (HP:0002224)2.04112385
64Small hand (HP:0200055)2.03321410
65Elevated erythrocyte sedimentation rate (HP:0003565)2.03236690
66Neonatal respiratory distress (HP:0002643)2.01838188
67Abnormality of the prostate (HP:0008775)2.01594287
68Pancreatic fibrosis (HP:0100732)1.98801787
69Cerebral palsy (HP:0100021)1.98130938
70Hypoplasia of the fovea (HP:0007750)1.97117505
71Aplasia/Hypoplasia of the fovea (HP:0008060)1.97117505
72Polydipsia (HP:0001959)1.96927524
73Abnormal drinking behavior (HP:0030082)1.96927524
74Medial flaring of the eyebrow (HP:0010747)1.94728371
75Abnormality of the renal medulla (HP:0100957)1.94588305
76Oral leukoplakia (HP:0002745)1.91898866
77Abnormality of serum amino acid levels (HP:0003112)1.91564451
78Spastic paraparesis (HP:0002313)1.91493454
79Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.90171048
80Type II lissencephaly (HP:0007260)1.87695240
81Generalized hypopigmentation of hair (HP:0011358)1.86413970
82Abnormality of magnesium homeostasis (HP:0004921)1.84991237
83Dysdiadochokinesis (HP:0002075)1.83903681
84Abnormality of the axillary hair (HP:0100134)1.83407907
85Abnormality of secondary sexual hair (HP:0009888)1.83407907
86IgG deficiency (HP:0004315)1.83147660
87Abnormality of the renal cortex (HP:0011035)1.82049254
88Pancytopenia (HP:0001876)1.80863311
89Homocystinuria (HP:0002156)1.80301362
90Abnormality of homocysteine metabolism (HP:0010919)1.80301362
91Thyroid-stimulating hormone excess (HP:0002925)1.80292492
92Hyperinsulinemic hypoglycemia (HP:0000825)1.79641441
93CNS demyelination (HP:0007305)1.79631732
94Volvulus (HP:0002580)1.78713642
95Gaze-evoked nystagmus (HP:0000640)1.78309940
96Ketosis (HP:0001946)1.78268412
97Aplasia/hypoplasia of the uterus (HP:0008684)1.75671884
98Megaloblastic anemia (HP:0001889)1.75148318
99Hypoplasia of the uterus (HP:0000013)1.75071328
100Intestinal atresia (HP:0011100)1.73139350

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK34.96437611
2FRK3.79342959
3EIF2AK13.75941593
4NUAK13.22389822
5TLK13.07066628
6VRK22.96685126
7MAP3K122.61176428
8TRIM282.52233716
9BMPR1B2.23356166
10ERBB31.93182268
11WNK31.85590993
12MYLK1.83363180
13WNK41.78151811
14ZAK1.77616255
15TXK1.77231027
16MAP4K21.72926566
17SCYL21.68312717
18MST41.66535694
19ADRBK21.50085237
20STK391.45633807
21PINK11.43724326
22TNIK1.43009372
23GRK11.41840408
24TAOK31.40768341
25NEK11.40213961
26PLK21.36215965
27CSNK1G31.32912381
28TSSK61.26436282
29PASK1.26011431
30VRK11.24905703
31CSNK1G11.18925157
32OXSR11.18155389
33TIE11.11759073
34PHKG21.11545318
35PHKG11.11545318
36PLK31.07800810
37MKNK21.07800237
38CSNK1G21.06322499
39MKNK11.06156055
40PRKCE1.01534706
41INSRR1.00491555
42DYRK20.96506401
43MAP4K10.94003166
44AKT30.93301588
45GRK50.90482571
46GRK60.78335597
47CSNK1A1L0.78087311
48EIF2AK20.77089710
49RPS6KA50.73752320
50CSNK1A10.71972156
51CASK0.69063162
52KIT0.68947178
53PRKCI0.68886929
54SYK0.67710804
55STK160.66072544
56PAK30.63851743
57TEC0.60995108
58ATR0.60169372
59PRKCG0.59765398
60TGFBR10.58715848
61CAMK2D0.56600847
62STK38L0.56401586
63LIMK10.54679256
64NTRK30.54369973
65ILK0.53260930
66MAPKAPK50.51710937
67ABL10.51578868
68RIPK40.49743362
69FER0.48417249
70PLK10.47929615
71RPS6KA40.47803604
72LYN0.47377910
73PRKG10.46719579
74EPHA40.43731008
75PRKACA0.43687885
76TAF10.43670270
77PRKCA0.43090129
78WEE10.41763022
79ADRBK10.41472382
80GRK70.41014979
81NLK0.40069406
82DMPK0.39689426
83ATM0.39173416
84OBSCN0.38775917
85FLT30.37091900
86DAPK10.36147496
87TYK20.35010450
88MUSK0.34869747
89IKBKB0.34775455
90STK30.34227820
91ALK0.33559177
92DYRK30.32892570
93CSNK2A20.32790752
94PIK3CG0.32314172
95BCKDK0.32278956
96AURKB0.31896308
97PTK2B0.31228738
98CSNK2A10.29648275
99FES0.29286561
100MAPK130.29197270

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.78700812
2Proteasome_Homo sapiens_hsa030503.81851344
3Asthma_Homo sapiens_hsa053103.37120657
4Oxidative phosphorylation_Homo sapiens_hsa001903.20793451
5Protein export_Homo sapiens_hsa030602.92525838
6Allograft rejection_Homo sapiens_hsa053302.64885979
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.59938644
8Autoimmune thyroid disease_Homo sapiens_hsa053202.55498200
9Type I diabetes mellitus_Homo sapiens_hsa049402.44884826
10Parkinsons disease_Homo sapiens_hsa050122.34109053
11Graft-versus-host disease_Homo sapiens_hsa053322.18227585
12RNA polymerase_Homo sapiens_hsa030202.08825446
13Phototransduction_Homo sapiens_hsa047441.74303948
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.71025197
15Linoleic acid metabolism_Homo sapiens_hsa005911.65770916
16Tryptophan metabolism_Homo sapiens_hsa003801.61541362
17Alzheimers disease_Homo sapiens_hsa050101.60748952
18Huntingtons disease_Homo sapiens_hsa050161.58103184
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57242912
20Rheumatoid arthritis_Homo sapiens_hsa053231.51418258
21Homologous recombination_Homo sapiens_hsa034401.47807996
22RNA degradation_Homo sapiens_hsa030181.44379558
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43978536
24Fatty acid elongation_Homo sapiens_hsa000621.43867821
25Fanconi anemia pathway_Homo sapiens_hsa034601.43297350
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41244858
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.41139041
28Nitrogen metabolism_Homo sapiens_hsa009101.39380074
29Propanoate metabolism_Homo sapiens_hsa006401.32720432
30Collecting duct acid secretion_Homo sapiens_hsa049661.27293392
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19136603
32Basal transcription factors_Homo sapiens_hsa030221.18635312
33Antigen processing and presentation_Homo sapiens_hsa046121.18071916
34Ether lipid metabolism_Homo sapiens_hsa005651.17798217
35Sulfur metabolism_Homo sapiens_hsa009201.16467651
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.15305533
37Regulation of autophagy_Homo sapiens_hsa041401.11615631
38Mismatch repair_Homo sapiens_hsa034301.09451157
39Viral myocarditis_Homo sapiens_hsa054161.08814323
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07877302
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02365680
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94205379
43One carbon pool by folate_Homo sapiens_hsa006700.93237303
44Ribosome_Homo sapiens_hsa030100.93211897
45Pyrimidine metabolism_Homo sapiens_hsa002400.92978421
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.92622072
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92426094
48Cardiac muscle contraction_Homo sapiens_hsa042600.91332126
49Olfactory transduction_Homo sapiens_hsa047400.91264073
50Staphylococcus aureus infection_Homo sapiens_hsa051500.90051337
51Arachidonic acid metabolism_Homo sapiens_hsa005900.89475786
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89083038
53Folate biosynthesis_Homo sapiens_hsa007900.89023947
54Butanoate metabolism_Homo sapiens_hsa006500.88496639
55Purine metabolism_Homo sapiens_hsa002300.86014625
56Nicotine addiction_Homo sapiens_hsa050330.84013719
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83961120
58Nucleotide excision repair_Homo sapiens_hsa034200.83741441
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81172014
60Chemical carcinogenesis_Homo sapiens_hsa052040.79343017
61DNA replication_Homo sapiens_hsa030300.77272929
62Primary immunodeficiency_Homo sapiens_hsa053400.74417055
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72809181
64Non-homologous end-joining_Homo sapiens_hsa034500.71082953
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66032365
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62908998
67Metabolic pathways_Homo sapiens_hsa011000.60484498
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.59552008
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59325683
70Peroxisome_Homo sapiens_hsa041460.59227091
71GABAergic synapse_Homo sapiens_hsa047270.57983906
72Morphine addiction_Homo sapiens_hsa050320.55192217
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53583290
74RNA transport_Homo sapiens_hsa030130.53538869
75Systemic lupus erythematosus_Homo sapiens_hsa053220.53038131
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52707518
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49750603
78Salivary secretion_Homo sapiens_hsa049700.46748820
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44951546
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42983149
81Pancreatic secretion_Homo sapiens_hsa049720.42690033
82Spliceosome_Homo sapiens_hsa030400.42490814
83Serotonergic synapse_Homo sapiens_hsa047260.42419624
84Phagosome_Homo sapiens_hsa041450.38890037
85Circadian entrainment_Homo sapiens_hsa047130.38383871
86Fat digestion and absorption_Homo sapiens_hsa049750.37697301
87Hematopoietic cell lineage_Homo sapiens_hsa046400.34864272
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33961816
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33552493
90Retinol metabolism_Homo sapiens_hsa008300.32642602
912-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32114044
92Glutamatergic synapse_Homo sapiens_hsa047240.29172796
93Sphingolipid metabolism_Homo sapiens_hsa006000.28841211
94Leishmaniasis_Homo sapiens_hsa051400.28294864
95Fatty acid metabolism_Homo sapiens_hsa012120.27144707
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26669238
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.26407019
98Fatty acid degradation_Homo sapiens_hsa000710.25956406
99Dopaminergic synapse_Homo sapiens_hsa047280.24793475
100Insulin secretion_Homo sapiens_hsa049110.23642245

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