CALM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of proteins that binds calcium and functions as a enzymatic co-factor. Activity of this protein is important in the regulation of the cell cycle and cytokinesis. Multiple alternatively spliced transcript variants have been observed at this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.64776736
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.38041300
3locomotory exploration behavior (GO:0035641)6.28185240
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.78793001
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.77564020
6vocalization behavior (GO:0071625)5.66569097
7synaptic vesicle exocytosis (GO:0016079)5.40453629
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.39643294
9glutamate secretion (GO:0014047)5.38516603
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.11733884
11regulation of synaptic vesicle exocytosis (GO:2000300)5.10686616
12regulation of glutamate receptor signaling pathway (GO:1900449)5.03262391
13layer formation in cerebral cortex (GO:0021819)5.02783642
14cerebellar granule cell differentiation (GO:0021707)4.92277570
15exploration behavior (GO:0035640)4.90899075
16protein localization to synapse (GO:0035418)4.79522994
17regulation of neuronal synaptic plasticity (GO:0048168)4.69101658
18dendritic spine morphogenesis (GO:0060997)4.67652802
19regulation of synapse structural plasticity (GO:0051823)4.64355467
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.63353865
21L-amino acid import (GO:0043092)4.59567201
22regulation of synaptic vesicle transport (GO:1902803)4.52172394
23ionotropic glutamate receptor signaling pathway (GO:0035235)4.49419743
24neurotransmitter secretion (GO:0007269)4.46824255
25amino acid import (GO:0043090)4.28775944
26neuronal action potential propagation (GO:0019227)4.26772472
27neuron cell-cell adhesion (GO:0007158)4.22076332
28sodium ion export (GO:0071436)4.09350218
29proline transport (GO:0015824)4.09129651
30cytoskeletal anchoring at plasma membrane (GO:0007016)4.08583050
31cellular potassium ion homeostasis (GO:0030007)4.03060200
32synaptic transmission, glutamatergic (GO:0035249)4.00697080
33negative regulation of dendrite morphogenesis (GO:0050774)3.96952381
34potassium ion homeostasis (GO:0055075)3.93876004
35activation of protein kinase A activity (GO:0034199)3.90035679
36long-term memory (GO:0007616)3.88628988
37glutamate receptor signaling pathway (GO:0007215)3.88604437
38neurotransmitter-gated ion channel clustering (GO:0072578)3.86216304
39gamma-aminobutyric acid transport (GO:0015812)3.85304681
40positive regulation of membrane potential (GO:0045838)3.82338268
41regulation of dendritic spine morphogenesis (GO:0061001)3.81444633
42positive regulation of synapse maturation (GO:0090129)3.80224335
43neuromuscular process controlling balance (GO:0050885)3.79958530
44regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.78119283
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.73247843
46regulation of synapse maturation (GO:0090128)3.69256727
47neuron-neuron synaptic transmission (GO:0007270)3.68653398
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.67836153
49regulation of synaptic plasticity (GO:0048167)3.62895723
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.60032607
51neuron recognition (GO:0008038)3.53613824
52neurotransmitter transport (GO:0006836)3.53578236
53cell communication by electrical coupling (GO:0010644)3.52614218
54regulation of postsynaptic membrane potential (GO:0060078)3.52596319
55synaptic vesicle endocytosis (GO:0048488)3.48744981
56dendrite morphogenesis (GO:0048813)3.45894780
57dendritic spine organization (GO:0097061)3.44834697
58G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.44645128
59potassium ion import (GO:0010107)3.42976874
60cellular sodium ion homeostasis (GO:0006883)3.40538067
61auditory behavior (GO:0031223)3.37533446
62negative regulation of synaptic transmission, GABAergic (GO:0032229)3.37412536
63regulation of neurotransmitter secretion (GO:0046928)3.34834122
64axonal fasciculation (GO:0007413)3.30876714
65regulation of ARF protein signal transduction (GO:0032012)3.29406485
66positive regulation of synaptic transmission, GABAergic (GO:0032230)3.28685592
67regulation of neurotransmitter levels (GO:0001505)3.28419560
68glycine transport (GO:0015816)3.27326582
69transmission of nerve impulse (GO:0019226)3.26854610
70vesicle docking involved in exocytosis (GO:0006904)3.26162447
71positive regulation of dendritic spine development (GO:0060999)3.24159342
72positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.23655627
73vesicle transport along microtubule (GO:0047496)3.21478927
74response to auditory stimulus (GO:0010996)3.19851777
75positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.19139355
76regulation of dendritic spine development (GO:0060998)3.18023099
77prepulse inhibition (GO:0060134)3.17962966
78regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.16757088
79regulation of vesicle fusion (GO:0031338)3.16656422
80cerebellar Purkinje cell differentiation (GO:0021702)3.16220979
81positive regulation of neurotransmitter secretion (GO:0001956)3.15356130
82cell migration in hindbrain (GO:0021535)3.15248444
83positive regulation of dendritic spine morphogenesis (GO:0061003)3.15237014
84long-term synaptic potentiation (GO:0060291)3.14269848
85neuronal ion channel clustering (GO:0045161)3.13205715
86innervation (GO:0060384)3.13000938
87postsynaptic membrane organization (GO:0001941)3.12980298
88cerebellar Purkinje cell layer development (GO:0021680)3.10195708
89positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.09454712
90negative regulation of microtubule polymerization (GO:0031115)3.07501030
91regulation of neurotransmitter transport (GO:0051588)3.06171126
92regulation of synaptic transmission, glutamatergic (GO:0051966)3.06147933
93positive regulation of neurotransmitter transport (GO:0051590)3.05060762
94regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.05054757
95neuromuscular process controlling posture (GO:0050884)3.04982421
96membrane depolarization (GO:0051899)3.04358614
97membrane depolarization during action potential (GO:0086010)3.02158256
98intraspecies interaction between organisms (GO:0051703)3.01070504
99social behavior (GO:0035176)3.01070504
100neuromuscular process (GO:0050905)3.00541011
101regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.97906269
102central nervous system myelination (GO:0022010)2.97895057
103axon ensheathment in central nervous system (GO:0032291)2.97895057
104organelle transport along microtubule (GO:0072384)2.97785193
105learning (GO:0007612)2.95515456
106gamma-aminobutyric acid signaling pathway (GO:0007214)2.94154928
107regulation of synaptic transmission (GO:0050804)2.93086546
108membrane hyperpolarization (GO:0060081)2.91651340
109establishment of nucleus localization (GO:0040023)2.91195507
110dopamine receptor signaling pathway (GO:0007212)2.90594387
111cell communication involved in cardiac conduction (GO:0086065)2.90438829
112acidic amino acid transport (GO:0015800)2.88619172
113negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.88053840
114clathrin coat assembly (GO:0048268)2.87947872
115vesicle docking (GO:0048278)2.87462960
116mating behavior (GO:0007617)2.87392260
117synapse assembly (GO:0007416)2.87137679
118regulation of exocytosis (GO:0017157)2.86108700
119positive regulation of dendrite development (GO:1900006)2.85229329
120establishment of mitochondrion localization (GO:0051654)2.82133969
121adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.81540360
122regulation of dendrite morphogenesis (GO:0048814)2.79465871
123dicarboxylic acid transport (GO:0006835)2.78285707
124establishment of synaptic vesicle localization (GO:0097480)2.78054962
125synaptic vesicle transport (GO:0048489)2.78054962

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.14080433
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07240777
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.06569667
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00058894
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.98149765
6REST_21632747_ChIP-Seq_MESCs_Mouse2.87175446
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80190649
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80190649
9DROSHA_22980978_ChIP-Seq_HELA_Human2.78605140
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.70330225
11GBX2_23144817_ChIP-Seq_PC3_Human2.60668734
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.60201721
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.59951118
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.55957122
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52421446
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.47908563
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.44858787
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43608321
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43505498
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.40168395
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.39079172
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.36366775
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.32674560
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.28472294
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.12191487
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.10556219
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.09621897
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99608734
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.86852088
30SRY_22984422_ChIP-ChIP_TESTIS_Rat1.81272610
31SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.68105598
32AR_21572438_ChIP-Seq_LNCaP_Human1.66363615
33* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65287311
34KDM2B_26808549_Chip-Seq_K562_Human1.59076451
35DNAJC2_21179169_ChIP-ChIP_NT2_Human1.55172294
36RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.53122129
37RING1B_27294783_Chip-Seq_ESCs_Mouse1.50665403
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.49866729
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48605020
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47672375
41ZNF274_21170338_ChIP-Seq_K562_Hela1.47372975
42EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.46374806
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41499534
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36257507
45* TCF7_22412390_ChIP-Seq_EML_Mouse1.34241049
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.32221537
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30870532
48WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28837839
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28343805
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.28292607
51CREB1_26743006_Chip-Seq_LNCaP_Human1.27469757
52SMAD4_21799915_ChIP-Seq_A2780_Human1.27398896
53* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26579463
54UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26453384
55RING1B_27294783_Chip-Seq_NPCs_Mouse1.26242975
56TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25756863
57ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25365741
58SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25342047
59* P68_20966046_ChIP-Seq_HELA_Human1.24359770
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24161981
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23334826
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22824949
63AR_19668381_ChIP-Seq_PC3_Human1.20942010
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.20649762
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19108852
66RACK7_27058665_Chip-Seq_MCF-7_Human1.16637819
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15603216
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14678754
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14231601
70* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12386237
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.11162349
72CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09835565
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08402754
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07545373
75* ELK3_25401928_ChIP-Seq_HUVEC_Human1.07519482
76CTCF_27219007_Chip-Seq_Bcells_Human1.06444802
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05260585
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.04518753
79TET1_21490601_ChIP-Seq_MESCs_Mouse1.03339942
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02897424
81CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02779423
82GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.02517276
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02374477
84RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99517862
85YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99428925
86SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98554180
87DPY_21335234_ChIP-Seq_ESCs_Mouse0.98106138
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97787926
89AR_25329375_ChIP-Seq_VCAP_Human0.97495595
90LXR_22292898_ChIP-Seq_THP-1_Human0.97269321
91SMAD3_21741376_ChIP-Seq_EPCs_Human0.96596588
92STAT3_23295773_ChIP-Seq_U87_Human0.95491059
93* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95332760
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94049196
95TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93609141
96* SMAD3_21741376_ChIP-Seq_ESCs_Human0.93079647
97KDM2B_26808549_Chip-Seq_DND41_Human0.92973383
98MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.92872527
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92757947
100ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92735163
101P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92524010
102* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.92142735
103* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91864218
104CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91826888
105VDR_21846776_ChIP-Seq_THP-1_Human0.91381719
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90906848
107OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90066714
108GATA1_26923725_Chip-Seq_HPCs_Mouse0.89769737
109* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89748724
110MYC_22102868_ChIP-Seq_BL_Human0.89708721
111ARNT_22903824_ChIP-Seq_MCF-7_Human0.89383774
112SMAD4_21741376_ChIP-Seq_HESCs_Human0.89100661
113* KDM2B_26808549_Chip-Seq_JURKAT_Human0.88928866
114CBX2_27304074_Chip-Seq_ESCs_Mouse0.88717937
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88046642
116TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88041630
117AHR_22903824_ChIP-Seq_MCF-7_Human0.87965362
118* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87576314
119TP53_23651856_ChIP-Seq_MEFs_Mouse0.87504673
120VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86167408
121TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.86158719
122SMAD3_21741376_ChIP-Seq_HESCs_Human0.86107216
123RUNX1_26923725_Chip-Seq_HPCs_Mouse0.84790468
124TCF4_23295773_ChIP-Seq_U87_Human0.84175271
125SMC4_20622854_ChIP-Seq_HELA_Human0.83352736
126SA1_27219007_Chip-Seq_Bcells_Human0.82919951
127* KLF4_19829295_ChIP-Seq_ESCs_Human0.82564415
128OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82374813
129SMAD_19615063_ChIP-ChIP_OVARY_Human0.81887471
130TP53_20018659_ChIP-ChIP_R1E_Mouse0.81683984
131SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79963783
132SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78706127
133P300_19829295_ChIP-Seq_ESCs_Human0.78566220
134TAF15_26573619_Chip-Seq_HEK293_Human0.78395258
135EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.77748613
136* OCT4_19829295_ChIP-Seq_ESCs_Human0.76872689

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.40600913
2MP0003880_abnormal_central_pattern4.52551356
3MP0003635_abnormal_synaptic_transmissio4.33037966
4MP0004270_analgesia3.96899349
5MP0002063_abnormal_learning/memory/cond3.45404974
6MP0009745_abnormal_behavioral_response3.33894338
7MP0002064_seizures3.10024837
8MP0009046_muscle_twitch2.88112783
9MP0001968_abnormal_touch/_nociception2.87979099
10MP0005423_abnormal_somatic_nervous2.85571950
11MP0002572_abnormal_emotion/affect_behav2.69402082
12MP0002734_abnormal_mechanical_nocicepti2.65876351
13MP0002822_catalepsy2.50976552
14MP0001486_abnormal_startle_reflex2.44563968
15MP0002272_abnormal_nervous_system2.43415196
16MP0004858_abnormal_nervous_system2.29119523
17MP0009780_abnormal_chondrocyte_physiolo2.24167067
18MP0003329_amyloid_beta_deposits2.16264791
19MP0002736_abnormal_nociception_after2.14443947
20MP0002735_abnormal_chemical_nociception2.10319442
21MP0002733_abnormal_thermal_nociception2.08182642
22MP0001440_abnormal_grooming_behavior2.04452576
23MP0001501_abnormal_sleep_pattern2.03169633
24MP0004811_abnormal_neuron_physiology2.01781095
25MP0008569_lethality_at_weaning1.98703652
26MP0001970_abnormal_pain_threshold1.96926023
27MP0002909_abnormal_adrenal_gland1.93980372
28MP0000778_abnormal_nervous_system1.91642529
29MP0003123_paternal_imprinting1.88154874
30MP0002184_abnormal_innervation1.80431984
31MP0002067_abnormal_sensory_capabilities1.78289758
32MP0000955_abnormal_spinal_cord1.71307092
33MP0002557_abnormal_social/conspecific_i1.69308454
34MP0005386_behavior/neurological_phenoty1.63445578
35MP0004924_abnormal_behavior1.63445578
36MP0004885_abnormal_endolymph1.60953600
37MP0003879_abnormal_hair_cell1.53977384
38MP0002882_abnormal_neuron_morphology1.45781274
39MP0002066_abnormal_motor_capabilities/c1.44634179
40MP0003633_abnormal_nervous_system1.40560964
41MP0003283_abnormal_digestive_organ1.31981547
42MP0006276_abnormal_autonomic_nervous1.28272752
43MP0003787_abnormal_imprinting1.26062557
44MP0000751_myopathy1.25352787
45MP0002152_abnormal_brain_morphology1.20237957
46MP0001984_abnormal_olfaction1.19697209
47MP0003631_nervous_system_phenotype1.18232829
48MP0005409_darkened_coat_color1.16593097
49MP0003705_abnormal_hypodermis_morpholog1.11978932
50MP0000569_abnormal_digit_pigmentation1.09696145
51MP0003075_altered_response_to1.09539078
52MP0008961_abnormal_basal_metabolism1.08656458
53MP0005623_abnormal_meninges_morphology1.08394387
54MP0005646_abnormal_pituitary_gland1.08114587
55MP0005645_abnormal_hypothalamus_physiol1.07810517
56MP0010234_abnormal_vibrissa_follicle1.06787345
57MP0003122_maternal_imprinting1.02824084
58MP0001502_abnormal_circadian_rhythm1.01917496
59MP0004142_abnormal_muscle_tone1.01431406
60MP0001346_abnormal_lacrimal_gland1.01325430
61MP0000013_abnormal_adipose_tissue0.99411997
62MP0001905_abnormal_dopamine_level0.99383634
63MP0004145_abnormal_muscle_electrophysio0.97016708
64MP0000604_amyloidosis0.96779879
65MP0003634_abnormal_glial_cell0.95026743
66MP0002069_abnormal_eating/drinking_beha0.91342926
67MP0001529_abnormal_vocalization0.91318352
68MP0008872_abnormal_physiological_respon0.90134612
69MP0002229_neurodegeneration0.88736176
70MP0001177_atelectasis0.88218752
71MP0008874_decreased_physiological_sensi0.86599455
72MP0004233_abnormal_muscle_weight0.86487706
73MP0003632_abnormal_nervous_system0.85011355
74MP0000566_synostosis0.83656647
75MP0000920_abnormal_myelination0.82893746
76MP0005167_abnormal_blood-brain_barrier0.80344128
77MP0003690_abnormal_glial_cell0.79738856
78MP0004085_abnormal_heartbeat0.77444347
79MP0005394_taste/olfaction_phenotype0.74545559
80MP0005499_abnormal_olfactory_system0.74545559
81MP0004510_myositis0.73676680
82MP0002837_dystrophic_cardiac_calcinosis0.73109582
83MP0005535_abnormal_body_temperature0.71993033
84MP0004742_abnormal_vestibular_system0.71754477
85MP0003137_abnormal_impulse_conducting0.69929607
86MP0001348_abnormal_lacrimal_gland0.69794644
87MP0003861_abnormal_nervous_system0.69731733
88MP0001963_abnormal_hearing_physiology0.66590349
89MP0002752_abnormal_somatic_nervous0.66165544
90MP0005187_abnormal_penis_morphology0.65396409
91MP0004484_altered_response_of0.64948093
92MP0002090_abnormal_vision0.64853682
93MP0005166_decreased_susceptibility_to0.64379365
94MP0000631_abnormal_neuroendocrine_gland0.64269078
95MP0004130_abnormal_muscle_cell0.61664293
96MP0003183_abnormal_peptide_metabolism0.61553564
97MP0004215_abnormal_myocardial_fiber0.61238838
98MP0001299_abnormal_eye_distance/0.61129910
99MP0003172_abnormal_lysosome_physiology0.61113176
100MP0005058_abnormal_lysosome_morphology0.60962512
101MP0010386_abnormal_urinary_bladder0.60799841
102MP0008260_abnormal_autophagy0.60402406
103MP0002089_abnormal_postnatal_growth/wei0.59382816
104MP0004147_increased_porphyrin_level0.58731587
105MP0001943_abnormal_respiration0.58628615
106MP0000747_muscle_weakness0.57228007
107MP0005551_abnormal_eye_electrophysiolog0.56617731
108MP0001664_abnormal_digestion0.56104444
109MP0010769_abnormal_survival0.55530855
110MP0001849_ear_inflammation0.55519328
111MP0010768_mortality/aging0.55195198
112MP0002249_abnormal_larynx_morphology0.54847369
113MP0002082_postnatal_lethality0.52509151
114MP0010770_preweaning_lethality0.52509151
115MP0001485_abnormal_pinna_reflex0.51900572
116MP0009672_abnormal_birth_weight0.51558627
117MP0003956_abnormal_body_size0.49921211
118MP0002873_normal_phenotype0.49254046
119MP0002169_no_abnormal_phenotype0.47894110
120MP0003045_fibrosis0.47085081
121MP0003303_peritoneal_inflammation0.46332278
122MP0001731_abnormal_postnatal_growth0.43435313
123MP0000681_abnormal_thyroid_gland0.42991264
124MP0003938_abnormal_ear_development0.42911930

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.15247304
2Focal motor seizures (HP:0011153)6.35060979
3Visual hallucinations (HP:0002367)5.45632663
4Focal seizures (HP:0007359)5.21301653
5Action tremor (HP:0002345)4.14214422
6Epileptic encephalopathy (HP:0200134)4.03212782
7Supranuclear gaze palsy (HP:0000605)4.01913490
8Progressive cerebellar ataxia (HP:0002073)3.91917696
9Atonic seizures (HP:0010819)3.79924888
10Ankle clonus (HP:0011448)3.76887779
11Absence seizures (HP:0002121)3.57418758
12Papilledema (HP:0001085)3.54160218
13Febrile seizures (HP:0002373)3.43458560
14Abnormality of the lower motor neuron (HP:0002366)3.42949825
15Generalized tonic-clonic seizures (HP:0002069)3.37611167
16Impaired vibration sensation in the lower limbs (HP:0002166)3.36609557
17Depression (HP:0000716)3.35273203
18Mutism (HP:0002300)3.34684121
19Tetraplegia (HP:0002445)3.31068722
20Poor eye contact (HP:0000817)3.26260713
21Dialeptic seizures (HP:0011146)3.19073709
22Urinary bladder sphincter dysfunction (HP:0002839)3.15081749
23Broad-based gait (HP:0002136)3.12053972
24Urinary urgency (HP:0000012)2.98542229
25Abnormal social behavior (HP:0012433)2.98057102
26Impaired social interactions (HP:0000735)2.98057102
27Postural instability (HP:0002172)2.95885571
28Cerebral inclusion bodies (HP:0100314)2.93334428
29Dysdiadochokinesis (HP:0002075)2.92224014
30Dysmetria (HP:0001310)2.89956691
31Amblyopia (HP:0000646)2.89848058
32Anxiety (HP:0000739)2.88833923
33Gaze-evoked nystagmus (HP:0000640)2.83984344
34Megalencephaly (HP:0001355)2.81392806
35Truncal ataxia (HP:0002078)2.81376464
36Abnormal eating behavior (HP:0100738)2.81004289
37Insomnia (HP:0100785)2.79032507
38Neurofibrillary tangles (HP:0002185)2.75787598
39Akinesia (HP:0002304)2.75177895
40Termporal pattern (HP:0011008)2.72305258
41Insidious onset (HP:0003587)2.72305258
42Torticollis (HP:0000473)2.71731373
43Ventricular fibrillation (HP:0001663)2.70833050
44Genetic anticipation (HP:0003743)2.68993547
45Annular pancreas (HP:0001734)2.64218591
46Peripheral hypomyelination (HP:0007182)2.63344394
47Impaired smooth pursuit (HP:0007772)2.63210462
48Intention tremor (HP:0002080)2.61891297
49Amyotrophic lateral sclerosis (HP:0007354)2.61033958
50Spastic gait (HP:0002064)2.60123331
51Cerebral hypomyelination (HP:0006808)2.55956666
52Hemiparesis (HP:0001269)2.53909040
53Pointed chin (HP:0000307)2.53066469
54Focal dystonia (HP:0004373)2.53059190
55Hemiplegia (HP:0002301)2.52999931
56Abnormality of binocular vision (HP:0011514)2.45883714
57Diplopia (HP:0000651)2.45883714
58Bradykinesia (HP:0002067)2.42877966
59Stereotypic behavior (HP:0000733)2.37174649
60Bundle branch block (HP:0011710)2.35994306
61Drooling (HP:0002307)2.34698648
62Excessive salivation (HP:0003781)2.34698648
63Abnormality of the corticospinal tract (HP:0002492)2.34551610
64Sleep apnea (HP:0010535)2.33677278
65Abnormality of ocular smooth pursuit (HP:0000617)2.30999895
66Progressive inability to walk (HP:0002505)2.29115675
67Dysmetric saccades (HP:0000641)2.28172039
68Lower limb muscle weakness (HP:0007340)2.27200221
69Apathy (HP:0000741)2.25287688
70Craniofacial dystonia (HP:0012179)2.23999603
71Distal upper limb amyotrophy (HP:0007149)2.19225035
72Upper limb amyotrophy (HP:0009129)2.19225035
73Obstructive sleep apnea (HP:0002870)2.19118989
74Limb dystonia (HP:0002451)2.18816631
75Impaired vibratory sensation (HP:0002495)2.17398056
76Turricephaly (HP:0000262)2.16269580
77Scanning speech (HP:0002168)2.14444052
78Rapidly progressive (HP:0003678)2.13326961
79Hyperventilation (HP:0002883)2.12573735
80Epileptiform EEG discharges (HP:0011182)2.09672223
81Spinal canal stenosis (HP:0003416)2.09428627
82Pheochromocytoma (HP:0002666)2.08355241
83Lower limb amyotrophy (HP:0007210)2.07067327
84Spastic tetraparesis (HP:0001285)2.06954052
85EEG with generalized epileptiform discharges (HP:0011198)2.06782527
86Ankyloglossia (HP:0010296)2.06118367
87Agitation (HP:0000713)2.04056952
88Aplasia involving bones of the extremities (HP:0009825)2.03792313
89Aplasia involving bones of the upper limbs (HP:0009823)2.03792313
90Aplasia of the phalanges of the hand (HP:0009802)2.03792313
91Fetal akinesia sequence (HP:0001989)2.03107961
92Lower limb asymmetry (HP:0100559)2.02970117
93Hypsarrhythmia (HP:0002521)2.02693391
94Diminished motivation (HP:0000745)1.99973233
95Clonus (HP:0002169)1.99182234
96Hand muscle atrophy (HP:0009130)1.96364024
97Neuronal loss in central nervous system (HP:0002529)1.95285939
98Abnormality of saccadic eye movements (HP:0000570)1.93840415
99Resting tremor (HP:0002322)1.92992503
100Hyperacusis (HP:0010780)1.90612530
101Inappropriate behavior (HP:0000719)1.89376008
102Hypercortisolism (HP:0001578)1.88666576
103Bronchomalacia (HP:0002780)1.88633812
104Hammertoe (HP:0001765)1.86378789
105Status epilepticus (HP:0002133)1.84749480
106Slow saccadic eye movements (HP:0000514)1.84013206
107Dementia (HP:0000726)1.83841117
108Neoplasm of the peripheral nervous system (HP:0100007)1.83502789
109Gait ataxia (HP:0002066)1.82538306
110Generalized myoclonic seizures (HP:0002123)1.81207729
111Intellectual disability, profound (HP:0002187)1.81006008
112Achilles tendon contracture (HP:0001771)1.80609297
113Incomplete penetrance (HP:0003829)1.80107595
114Distal sensory impairment (HP:0002936)1.79485483
115Absent speech (HP:0001344)1.79207175
116Polyphagia (HP:0002591)1.78914272
117Delusions (HP:0000746)1.78787518
118Hypoventilation (HP:0002791)1.77014204
119Rigidity (HP:0002063)1.76043956
120Foot dorsiflexor weakness (HP:0009027)1.75832537
121Abnormal EKG (HP:0003115)1.74262422
122Hyperthyroidism (HP:0000836)1.73318560
123Decreased motor nerve conduction velocity (HP:0003431)1.72449751
124Hyperparathyroidism (HP:0000843)1.71595528
125Abnormal gallbladder physiology (HP:0012438)1.70645577
126Cholecystitis (HP:0001082)1.70645577

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.19457295
2EPHA43.99677518
3NTRK33.98903382
4MARK13.59995317
5MAP3K42.74282001
6PRKD32.67670320
7DAPK22.63612453
8PAK62.55557549
9KSR22.49790363
10* MINK12.39117314
11CAMKK12.15344252
12NTRK22.08522818
13NTRK12.05429188
14MAP2K71.94863950
15KSR11.68519567
16MAP2K41.65756691
17CDK51.60712341
18RIPK41.57208160
19DAPK11.54257282
20TYRO31.50198318
21MAP3K121.47023233
22STK381.46019522
23LATS21.44791420
24SIK21.42532832
25MAP3K21.34267755
26PHKG21.33758930
27PHKG11.33758930
28UHMK11.31606003
29TAOK11.27577804
30GRK51.27318786
31EEF2K1.23835672
32PLK21.21343988
33ARAF1.19573768
34LMTK21.17676329
35MAP3K111.13362399
36PRKCG1.13166871
37ALK1.11991969
38PNCK1.10376657
39TAOK21.09630808
40MAPK131.07685812
41CDK191.06934470
42FES1.06242392
43RET1.04936563
44CDK151.03780485
45RIPK11.03465300
46CDK181.02353843
47MAPK121.01260829
48STK111.00799700
49TESK11.00037630
50CDK140.99505225
51PRPF4B0.96311239
52PRKCH0.94693784
53CDK11A0.91447420
54SCYL20.89463880
55TRIB30.89150442
56PAK30.86520229
57BRAF0.85810502
58CAMK10.85472949
59NEK10.83304227
60CAMKK20.82414562
61RAF10.82314238
62PTK2B0.81108392
63MAP3K130.79449497
64CAMK2A0.79316116
65SMG10.75896180
66PDK10.73975906
67MARK20.73088389
68TNIK0.69406409
69ICK0.69259017
70PINK10.67361221
71PDPK10.65749822
72CSNK1G20.64029945
73DDR20.63922600
74NEK60.63673887
75SGK4940.63527495
76SGK2230.63527495
77CAMK2B0.62844766
78MAP3K10.58747422
79DYRK1A0.58456004
80CAMK2G0.58329758
81SGK10.57861535
82DAPK30.56351389
83CAMK1D0.56158323
84PRKCZ0.55885772
85BRSK10.55467547
86CDC42BPA0.52059541
87PDGFRA0.51628351
88PRKG20.50751617
89CDK120.50629330
90SGK30.50610139
91FYN0.50557064
92MAP3K70.49376860
93CCNB10.49313159
94RPS6KA30.49082814
95DMPK0.48410381
96SGK20.48007573
97CAMK1G0.47760465
98MOS0.46497923
99FGR0.45167846
100MAP2K60.44508554
101FGFR40.44371417
102PKN20.44341833
103MAPK100.42987768
104RPS6KA20.42510472
105BMPR20.41665906
106FER0.41498476
107PKN10.41475434
108MAP2K10.41297386
109WNK10.40648144
110LIMK10.40570601
111CAMK40.40235781
112PDK40.39954951
113PDK30.39954951
114CASK0.38764826
115NME10.38380809
116BMX0.37942021
117TNK20.37381024
118OXSR10.37116915
119IRAK20.36016340
120SIK10.35806839
121ROCK20.35306960
122TESK20.33933340

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.18375687
2Nicotine addiction_Homo sapiens_hsa050333.15515396
3* Long-term potentiation_Homo sapiens_hsa047202.57522263
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.55445254
5* Olfactory transduction_Homo sapiens_hsa047402.55234250
6* Circadian entrainment_Homo sapiens_hsa047132.51490669
7GABAergic synapse_Homo sapiens_hsa047272.49358173
8Glutamatergic synapse_Homo sapiens_hsa047242.48306203
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.39090889
10Morphine addiction_Homo sapiens_hsa050322.27638046
11* Amphetamine addiction_Homo sapiens_hsa050312.23001429
12* Dopaminergic synapse_Homo sapiens_hsa047282.08119862
13* Salivary secretion_Homo sapiens_hsa049702.02318096
14Insulin secretion_Homo sapiens_hsa049111.98131328
15Cholinergic synapse_Homo sapiens_hsa047251.95633103
16* Gastric acid secretion_Homo sapiens_hsa049711.91378859
17* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77683943
18* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.77518242
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.69250334
20* Oxytocin signaling pathway_Homo sapiens_hsa049211.65497675
21Long-term depression_Homo sapiens_hsa047301.63097506
22Cocaine addiction_Homo sapiens_hsa050301.55089927
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.53089353
24Gap junction_Homo sapiens_hsa045401.50136145
25* Renin secretion_Homo sapiens_hsa049241.46260947
26Taste transduction_Homo sapiens_hsa047421.46251197
27* GnRH signaling pathway_Homo sapiens_hsa049121.45366059
28* Calcium signaling pathway_Homo sapiens_hsa040201.42568303
29Serotonergic synapse_Homo sapiens_hsa047261.38003693
30Vitamin B6 metabolism_Homo sapiens_hsa007501.29814347
31* Glioma_Homo sapiens_hsa052141.29352834
32Type II diabetes mellitus_Homo sapiens_hsa049301.28160845
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26341471
34* Estrogen signaling pathway_Homo sapiens_hsa049151.25631202
35* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24062044
36Nitrogen metabolism_Homo sapiens_hsa009101.23219541
37Axon guidance_Homo sapiens_hsa043601.20532283
38* cAMP signaling pathway_Homo sapiens_hsa040241.19135656
39ErbB signaling pathway_Homo sapiens_hsa040121.15805110
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11059763
41* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05623457
42* Melanogenesis_Homo sapiens_hsa049161.04160905
43* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03528393
44Collecting duct acid secretion_Homo sapiens_hsa049661.00392500
45* Oocyte meiosis_Homo sapiens_hsa041141.00301164
46Dorso-ventral axis formation_Homo sapiens_hsa043201.00250309
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.99014410
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97824199
49Cardiac muscle contraction_Homo sapiens_hsa042600.95948482
50VEGF signaling pathway_Homo sapiens_hsa043700.94631727
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90386216
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90013307
53Thyroid hormone synthesis_Homo sapiens_hsa049180.86413813
54Pancreatic secretion_Homo sapiens_hsa049720.86245415
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84639535
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83793294
57* Vascular smooth muscle contraction_Homo sapiens_hsa042700.82938362
58Dilated cardiomyopathy_Homo sapiens_hsa054140.82901730
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81958002
60mTOR signaling pathway_Homo sapiens_hsa041500.80788519
61Choline metabolism in cancer_Homo sapiens_hsa052310.80348718
62* Neurotrophin signaling pathway_Homo sapiens_hsa047220.79502522
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74761480
64MAPK signaling pathway_Homo sapiens_hsa040100.74561742
65Vibrio cholerae infection_Homo sapiens_hsa051100.73501870
66Endometrial cancer_Homo sapiens_hsa052130.72484747
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71747363
68Endocytosis_Homo sapiens_hsa041440.71067739
69Non-small cell lung cancer_Homo sapiens_hsa052230.68558974
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.66505566
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63913762
72* Rap1 signaling pathway_Homo sapiens_hsa040150.60432209
73Renal cell carcinoma_Homo sapiens_hsa052110.60254508
74* Alcoholism_Homo sapiens_hsa050340.59924454
75Arginine biosynthesis_Homo sapiens_hsa002200.59287794
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59161821
77* Glucagon signaling pathway_Homo sapiens_hsa049220.58647596
78Bile secretion_Homo sapiens_hsa049760.57089180
79AMPK signaling pathway_Homo sapiens_hsa041520.56693152
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56590911
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56077413
82* Ras signaling pathway_Homo sapiens_hsa040140.55491008
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55388841
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53703397
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52829265
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51475535
87Wnt signaling pathway_Homo sapiens_hsa043100.50305464
88* Insulin signaling pathway_Homo sapiens_hsa049100.50127610
89Inositol phosphate metabolism_Homo sapiens_hsa005620.48682552
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48336836
91Prion diseases_Homo sapiens_hsa050200.48056585
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47737661
93Chronic myeloid leukemia_Homo sapiens_hsa052200.47418954
94B cell receptor signaling pathway_Homo sapiens_hsa046620.46629259
95Colorectal cancer_Homo sapiens_hsa052100.46484971
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.45323339
97HIF-1 signaling pathway_Homo sapiens_hsa040660.44985066
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41784577
99Chemokine signaling pathway_Homo sapiens_hsa040620.41219862
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39880542
101Tight junction_Homo sapiens_hsa045300.39739131
102Arginine and proline metabolism_Homo sapiens_hsa003300.38816976
103Type I diabetes mellitus_Homo sapiens_hsa049400.37986255
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37416970
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37019171
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36080968
107Salmonella infection_Homo sapiens_hsa051320.35629137
108Platelet activation_Homo sapiens_hsa046110.34669960
109Prolactin signaling pathway_Homo sapiens_hsa049170.33213050
110Amoebiasis_Homo sapiens_hsa051460.32943328
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32613380
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30459454
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29721320
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28459880

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